392:
therapies; 88% had received four or more prior lines of therapies. Efficacy was evaluated in 100 people who received idecabtagene vicleucel in the dose range of 300 to 460 ×10 CAR-positive T cells. Overall, 72% of people partially or completely responded to the treatment. Of those studied, 28% of people showed complete response—or disappearance of all signs of multiple myeloma—to idecabtagene vicleucel, and 65% of this group remained in complete response to the treatment for at least twelve months.
2774:
836:
732:
589:
355:
Multiple myeloma is an uncommon type of blood cancer in which abnormal plasma cells build up in the bone marrow and form tumors in many bones of the body. This disease keeps the bone marrow from making enough healthy blood cells, which can result in low blood counts. Myeloma can also damage the bones
391:
The safety and efficacy of idecabtagene vicleucel were evaluated in a multicenter study of 127 people with relapsed (myeloma that returns after completion of treatment) and refractory (myeloma that does not respond to treatment) multiple myeloma who received at least three prior lines of antimyeloma
328:
therapy. Each dose is customized using a patient's own T-cells, which are a type of white blood cell, that are collected and genetically modified to include a new gene that facilitates targeting and killing myeloma cells, and infused back into the patient.
821:
380:. CRS and HLH/MAS are systemic responses to the activation and proliferation of CAR-T cells causing high fever and flu-like symptoms, and prolonged cytopenia is a drop in the number of a certain blood cell type for an extended period of time.
356:
and the kidneys and weaken the immune system. The exact cause of multiple myeloma is unknown. According to the
National Cancer Institute, myeloma accounted for approximately 1.8% (32,000) of all new cancer cases in the United States in 2020.
809:
717:
750:"U.S. Food and Drug Administration Approves Bristol Myers Squibb's and bluebird bio's Abecma (idecabtagene vicleucel), the First Anti-BCMA CAR T Cell Therapy for Relapsed or Refractory Multiple Myeloma"
486:
159:
810:"FDA Requires Boxed Warning for T cell Malignancies Following Treatment with BCMA-Directed or CD19-Directed Autologous Chimeric Antigen Receptor (CAR) T cell Immunotherapies"
1052:
2794:
705:
71:
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348:
for the treatment of adults with relapsed or refractory multiple myeloma after two or more prior lines of therapy, including an immunomodulatory agent, a
574:
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650:
332:
Idecabtagene vicleucel was approved for medical use in the United States in March 2021. It is the first cell-based gene therapy approved by the US
1004:
945:
2728:
1045:
322:
2335:
757:
478:
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World Health
Organization (2019). "International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 81".
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1038:
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336:(FDA) for the treatment of multiple myeloma. It was approved for medical use in the European Union in August 2021.
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2483:
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614:
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41:
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for "Efficacy and Safety Study of bb2121 in
Subjects With Relapsed and Refractory Multiple Myeloma (KarMMa)" at
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450:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
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53:
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Munshi NC, Anderson LD, Shah N, Madduri D, Berdeja J, Lonial S, et al. (February 2021).
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In April 2024, the FDA label boxed warning was expanded to include T cell malignancies.
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706:"FDA Approves First Cell-Based Gene Therapy for Adult Patients with Multiple Myeloma"
593:
365:
220:
95:
953:
Raje N, Berdeja J, Lin Y, Siegel D, Jagannath S, Madduri D, et al. (May 2019).
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2019:
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955:"Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma"
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914:
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1413:
1227:
1088:
408:
307:
1152:
888:"Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma"
276:
839:
This article incorporates text from this source, which is in the
735:
This article incorporates text from this source, which is in the
592:
This article incorporates text from this source, which is in the
267:
229:
1034:
214:
112:
457:
368:
for cytokine release syndrome (CRS), neurologic toxicity,
399:(FDA) granted the application for idecabtagene vicleucel
198:
310:, musculoskeletal pain, and a weakened immune system (
2762:
407:
designations. The FDA granted approval of Abecma to
2420:
2371:
2151:
2144:
2080:
2034:
1967:
1924:
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1521:
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1373:
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1219:
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1078:
364:The FDA label for idecabtagene vicleucel carries a
266:
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88:
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52:
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35:
28:
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557:
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8:
553:
551:
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547:
545:
543:
541:
539:
537:
535:
479:"Summary Basis of Decision (SBD) for Abecma"
121:
21:
514:"Abecma- idecabtagene vicleucel suspension"
2148:
1758:
1518:
1233:
1216:
1094:
1053:
1039:
1031:
980:
970:
913:
903:
866:
255:
352:, and an anti-CD38 monoclonal antibody.
295:, is a cell-based gene therapy to treat
2795:Drugs developed by Bristol Myers Squibb
2769:
441:
94:
996:
937:
326:chimeric antigen receptor (CAR) T-cell
20:
321:(BCMA)-directed genetically modified
302:The most common side effects include
80:
7:
784:Union Register of medicinal products
647:Union Register of medicinal products
577:from the original on 9 December 2023
171:
1322:ribonucleotide reductase inhibitors
790:from the original on 1 October 2023
623:from the original on 26 August 2021
275:
1488:Ribonucleotide reductase inhibitor
1444:Ribonucleotide reductase inhibitor
1003:: CS1 maint: overridden setting (
944:: CS1 maint: overridden setting (
824:from the original on 19 April 2024
760:from the original on 29 March 2021
720:from the original on 28 March 2021
370:hemophagocytic lymphohistiocytosis
14:
1247:Dihydrofolate reductase inhibitor
653:from the original on 5 March 2023
430:international nonproprietary name
2772:
834:
730:
716:(Press release). 27 March 2021.
587:
489:from the original on 29 May 2022
1384:Thymidylate synthase inhibitor
1274:Thymidylate synthase inhibitor
428:Idecabtagene vicleucel is the
374:macrophage activation syndrome
1:
1304:Adenosine deaminase inhibitor
1145:Block microtubule disassembly
816:Food and Drug Administration
712:Food and Drug Administration
643:"Abecma Product information"
569:Food and Drug Administration
397:Food and Drug Administration
334:Food and Drug Administration
317:Idecabtagene vicleucel is a
291:, sold under the brand name
2831:
768:– via Business Wire.
344:Idecabtagene vicleucel is
2723:
2604:Omacetaxine mepesuccinate
2484:Ciltacabtagene autoleucel
2474:Brexucabtagene autoleucel
615:European Medicines Agency
376:(HLH/MAS), and prolonged
319:B-cell maturation antigen
304:cytokine release syndrome
2656:Talimogene laherparepvec
2589:Nadofaragene firadenovec
2559:Lisocabtagene maraleucel
1508:Topoisomerase inhibitors
1427:DNA polymerase inhibitor
2805:Approved gene therapies
2459:Axicabtagene ciloleucel
1063:chemotherapeutic agents
16:Gene therapy medication
2641:Sitimagene ceradenovec
2539:Idecabtagene vicleucel
2104:Methyl aminolevulinate
1018:Clinical trial number
289:Idecabtagene vicleucel
123:Idecabtagene vicleucel
23:Idecabtagene vicleucel
2115:Porphyrin derivatives
1811:Melphalan flufenamide
1458:Hypomethylating agent
1067:antineoplastic agents
972:10.1056/NEJMoa1817226
905:10.1056/NEJMoa2024850
312:hypogammaglobulinemia
2444:Asparagine depleters
2373:Receptor antagonists
2287:+abiraterone acetate
855:WHO Drug Information
754:Bristol Myers Squibb
413:Bristol-Myers Squibb
401:breakthrough therapy
350:proteasome inhibitor
2494:Denileukin diftitox
2394:Retinoid X receptor
2094:Aminolevulinic acid
1916:Triethylenemelamine
1748:Crosslinking of DNA
1479:Deoxyribonucleotide
1418:+gimeracil/oteracil
485:. 23 October 2014.
419:Society and culture
409:Celgene Corporation
306:(CRS), infections,
25:
2810:CAR T-cell therapy
2750:Never to phase III
1552:Etirinotecan pegol
1026:ClinicalTrials.gov
786:. 19 August 2021.
2800:Cancer treatments
2760:
2759:
2719:
2718:
2676:Tigilanol tiglate
2153:Enzyme inhibitors
2076:
2075:
2072:
2071:
1772:Nitrogen mustards
1742:
1741:
1502:
1501:
1204:
1203:
820:. 18 April 2024.
756:. 26 March 2021.
752:(Press release).
573:. 27 March 2021.
286:
285:
233:
218:
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115:
2822:
2777:
2776:
2775:
2768:
2681:Tisagenlecleucel
2438:Arsenic trioxide
2149:
2082:Photosensitizers
1873:Alkyl sulfonates
1787:Cyclophosphamide
1759:
1698:Anthracenediones
1519:
1493:Hydroxycarbamide
1234:
1217:
1095:
1055:
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619:. 23 June 2021.
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454:nctr-crs.fda.gov
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297:multiple myeloma
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2761:
2756:
2755:
2740:Clinical trials
2715:
2421:Other/ungrouped
2416:
2367:
2140:
2120:Porfimer sodium
2068:
2030:
1963:
1920:
1750:
1738:
1622:
1592:
1510:
1498:
1473:
1369:
1289:
1225:
1223:antimetabolites
1221:
1220:DNA precursors/
1212:
1210:DNA replication
1200:
1140:
1110:Vinca alkaloids
1086:
1074:
1059:
1015:
995:
965:(18): 1726–37.
952:
936:
885:
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880:Further reading
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360:Adverse effects
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66:bb2121, ide-cel
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2349:
2344:
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2281:
2274:PARP inhibitor
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1926:Platinum-based
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1641:Anthracyclines
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1359:Mercaptopurine
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1061:Intracellular
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1013:External links
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531:
520:. 29 July 2024
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153:Antineoplastic
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2712:
2709:
2707:
2704:
2702:
2699:
2697:
2694:
2692:
2689:
2687:
2684:
2682:
2679:
2677:
2674:
2672:
2669:
2667:
2664:
2662:
2659:
2657:
2654:
2652:
2649:
2647:
2644:
2642:
2639:
2637:
2634:
2631:
2628:
2626:
2622:
2621:
2617:
2615:
2614:Tabelecleucel
2612:
2610:
2607:
2605:
2602:
2600:
2597:
2595:
2592:
2590:
2587:
2585:
2582:
2580:
2577:
2575:
2574:Lurbinectedin
2572:
2570:
2567:
2565:
2562:
2560:
2557:
2555:
2552:
2550:
2547:
2545:
2542:
2540:
2537:
2535:
2532:
2530:
2527:
2525:
2522:
2520:
2517:
2515:
2512:
2510:
2507:
2505:
2502:
2500:
2497:
2495:
2492:
2490:
2487:
2485:
2482:
2480:
2477:
2475:
2472:
2470:
2467:
2465:
2462:
2460:
2457:
2454:
2450:
2446:
2445:
2441:
2439:
2436:
2434:
2431:
2429:
2426:
2425:
2423:
2419:
2412:
2408:
2407:
2403:
2400:
2396:
2395:
2391:
2388:
2384:
2383:
2379:
2378:
2376:
2374:
2370:
2363:
2360:
2358:
2355:
2353:
2350:
2348:
2345:
2343:
2339:
2337:
2333:
2330:
2327:
2325:
2322:
2320:
2317:
2315:
2312:
2310:
2306:
2305:
2301:
2298:
2295:
2293:
2290:
2288:
2285:
2282:
2280:
2276:
2275:
2271:
2268:
2264:
2263:
2259:
2256:
2252:
2251:
2247:
2244:
2240:
2239:
2235:
2231:
2228:
2226:
2223:
2221:
2218:
2216:
2213:
2212:
2211:
2210:
2206:
2203:
2200:
2198:
2195:
2193:
2190:
2188:
2185:
2183:
2179:
2178:
2175:
2171:
2168:
2164:
2163:
2159:
2158:
2156:
2154:
2150:
2147:
2143:
2136:
2133:
2131:
2128:
2126:
2123:
2121:
2117:
2116:
2112:
2110:
2107:
2105:
2102:
2100:
2097:
2095:
2092:
2091:
2089:
2087:
2083:
2079:
2064:
2061:
2059:
2056:
2054:
2051:
2049:
2045:
2042:
2041:
2039:
2037:
2036:Intercalation
2033:
2026:
2023:
2021:
2018:
2016:
2012:
2011:
2007:
2005:
2002:
2000:
1997:
1995:
1992:
1989:
1985:
1984:
1980:
1978:
1975:
1974:
1972:
1970:
1966:
1960:
1957:
1955:
1952:
1950:
1947:
1945:
1944:Dicycloplatin
1942:
1940:
1937:
1935:
1932:
1931:
1929:
1927:
1923:
1917:
1914:
1912:
1909:
1907:
1904:
1902:
1899:
1897:
1893:
1892:
1888:
1885:
1883:
1879:
1876:
1874:
1870:
1869:
1866:
1863:
1861:
1858:
1856:
1853:
1850:
1846:
1843:
1841:
1838:
1836:
1833:
1831:
1827:
1826:
1823:
1820:
1818:
1817:Prednimustine
1815:
1812:
1808:
1805:
1803:
1800:
1797:
1794:
1792:
1788:
1785:
1783:
1780:
1778:
1775:
1773:
1769:
1768:
1766:
1764:
1760:
1757:
1754:
1749:
1745:
1735:
1732:
1730:
1727:
1725:
1722:
1720:
1717:
1714:
1711:
1709:
1706:
1704:
1700:
1699:
1695:
1692:
1689:
1687:
1684:
1682:
1679:
1677:
1674:
1672:
1669:
1667:
1664:
1661:
1657:
1654:
1652:
1649:
1647:
1643:
1642:
1638:
1637:
1635:
1633:
1632:Intercalation
1629:
1625:
1618:
1615:
1613:
1609:
1608:
1604:
1603:
1601:
1599:
1595:
1588:
1585:
1583:
1580:
1578:
1575:
1573:
1570:
1568:
1565:
1563:
1560:
1558:
1555:
1553:
1550:
1548:
1545:
1543:
1540:
1538:
1534:
1533:
1529:
1528:
1526:
1524:
1520:
1517:
1514:
1509:
1505:
1494:
1490:
1489:
1485:
1484:
1482:
1480:
1476:
1469:
1466:
1464:
1460:
1459:
1455:
1454:
1450:
1446:
1445:
1441:
1440:
1436:
1435:+daunorubicin
1433:
1429:
1428:
1424:
1423:
1419:
1415:
1412:
1410:
1407:
1405:
1402:
1400:
1399:Doxifluridine
1397:
1395:
1392:
1390:
1386:
1385:
1381:
1380:
1378:
1376:
1372:
1365:
1362:
1360:
1356:
1355:
1351:
1349:
1348:Rabacfosadine
1346:
1344:
1341:
1338:
1335:
1333:
1330:
1328:
1324:
1323:
1319:
1315:
1314:
1310:
1306:
1305:
1301:
1300:
1298:
1296:
1292:
1285:
1282:
1280:
1276:
1275:
1271:
1268:
1265:
1263:
1260:
1258:
1255:
1253:
1249:
1248:
1244:
1243:
1241:
1239:
1235:
1232:
1229:
1224:
1218:
1215:
1211:
1207:
1196:
1192:
1191:
1187:
1184:
1181:
1179:
1176:
1174:
1171:
1169:
1166:
1164:
1161:
1159:
1155:
1154:
1150:
1149:
1147:
1143:
1136:
1133:
1131:
1128:
1126:
1123:
1121:
1118:
1116:
1112:
1111:
1107:
1106:
1104:
1101:
1096:
1093:
1090:
1085:
1081:
1077:
1072:
1068:
1064:
1056:
1051:
1049:
1044:
1042:
1037:
1036:
1033:
1027:
1023:
1022:
1017:
1016:
1012:
1006:
1000:
992:
988:
983:
978:
973:
968:
964:
960:
956:
951:
947:
941:
933:
929:
925:
921:
916:
911:
906:
901:
898:(8): 705–16.
897:
893:
889:
884:
883:
879:
869:
864:
860:
856:
849:
846:
842:
841:public domain
823:
819:
817:
811:
805:
802:
789:
785:
781:
775:
772:
759:
755:
751:
745:
742:
738:
737:public domain
719:
715:
713:
707:
701:
699:
697:
695:
693:
691:
689:
687:
685:
683:
681:
679:
677:
675:
673:
671:
669:
665:
652:
648:
644:
638:
635:
622:
618:
616:
611:
610:"Abecma EPAR"
605:
603:
599:
595:
594:public domain
576:
572:
570:
564:
558:
556:
554:
552:
550:
548:
546:
544:
542:
540:
538:
536:
532:
519:
515:
509:
507:
505:
501:
488:
484:
483:Health Canada
480:
474:
471:
459:
455:
451:
445:
442:
435:
433:
431:
423:
418:
416:
414:
410:
406:
402:
398:
393:
386:
384:
381:
379:
375:
371:
367:
366:boxed warning
359:
357:
353:
351:
347:
339:
337:
335:
330:
327:
324:
320:
315:
313:
309:
305:
300:
298:
294:
290:
278:
274:
273:
271:
269:
265:
258:
254:
253:
251:
249:
245:
240:
234: Rx-only
227:
224:
212:
205:
196:
195:
193:
191:
187:
182:
174:
169:
166:
165:
163:
161:
157:
154:
151:
149:
145:
142:
139:
137:
131:
124:
119:
110:
109:
107:
105:
101:
97:
93:
91:
87:
83:
79:
77:
73:
69:
65:
61:
57:
55:
51:
48:Clinical data
46:
43:
40:
38:
34:
31:
27:
19:
2815:Orphan drugs
2661:Tazemetostat
2625:Alitretinoin
2618:
2538:
2529:Estramustine
2509:Elsamitrucin
2499:Eflornithine
2453:Pegaspargase
2449:Asparaginase
2442:
2411:Testolactone
2404:
2392:
2380:
2334:
2319:Panobinostat
2302:
2272:
2260:
2248:
2236:
2207:
2172:
2160:
2113:
2109:Padeliporfin
2048:Dactinomycin
2044:Streptomyces
2025:Temozolomide
2020:Mitozolomide
2008:
1999:Mitobronitol
1988:Procarbazine
1981:
1969:Nonclassical
1894:
1871:
1865:Streptozocin
1830:Nitrosoureas
1828:
1802:Chlorambucil
1796:Trofosfamide
1782:Chlormethine
1777:Bendamustine
1770:
1708:Mitoxantrone
1703:Losoxantrone
1696:
1656:Daunorubicin
1639:
1605:
1542:Camptothecin
1530:
1486:
1456:
1442:
1425:
1409:Fluorouracil
1389:Capecitabine
1382:
1352:
1316:
1302:
1272:
1267:Pralatrexate
1257:Methotrexate
1245:
1188:
1151:
1108:
1019:
999:cite journal
962:
959:N Engl J Med
958:
940:cite journal
915:11585/865225
895:
892:N Engl J Med
891:
868:10665/330896
858:
854:
848:
826:. Retrieved
813:
804:
792:. Retrieved
783:
774:
762:. Retrieved
744:
722:. Retrieved
709:
655:. Retrieved
646:
637:
625:. Retrieved
613:
579:. Retrieved
566:
524:20 September
522:. Retrieved
517:
491:. Retrieved
482:
473:
461:. Retrieved
453:
444:
427:
394:
390:
382:
363:
354:
343:
340:Medical uses
331:
316:
301:
292:
288:
287:
190:Legal status
184:Legal status
104:License data
30:Gene therapy
18:
2736:from market
2706:Vorasidenib
2686:Trabectedin
2671:Tiazofurine
2666:Tebentafusp
2651:Tagraxofusp
2609:Plitidepsin
2579:Mitoguazone
2519:Epacadostat
2489:Demecolcine
2433:Aflibercept
2406:Sex steroid
2279:Fuzuloparib
2220:Carfilzomib
2192:Palbociclib
2182:Abemaciclib
2135:Verteporfin
2099:Efaproxiral
2015:Dacarbazine
1977:Altretamine
1959:Satraplatin
1954:Oxaliplatin
1934:Carboplatin
1911:Triaziquone
1882:Mannosulfan
1860:Ranimustine
1840:Fotemustine
1681:Pirarubicin
1666:Doxorubicin
1660:+cytarabine
1646:Aclarubicin
1607:Podophyllum
1532:Camptotheca
1463:Azacitidine
1449:Gemcitabine
1404:Floxuridine
1337:Fludarabine
1332:Clofarabine
1318:Halogenated
1309:Pentostatin
1284:Raltitrexed
1252:Aminopterin
1195:Ixabepilone
1190:Epothilones
1158:Cabazitaxel
1135:Vinorelbine
1120:Vincristine
1115:Vinblastine
1100:microtubule
1021:NCT03361748
861:(1): 78-9.
405:orphan drug
242:Identifiers
225:Rx-only<
141:Intravenous
90:MedlinePlus
63:Other names
54:Trade names
37:Target gene
2789:Categories
2701:Verdinexor
2696:Venetoclax
2599:Oblimersen
2594:Navitoclax
2569:Lucanthone
2564:Lonidamine
2554:Lifileucel
2549:Ivosidenib
2544:Imetelstat
2514:Enasidenib
2504:Elesclomol
2469:Bexarotene
2464:Belzutifan
2399:Bexarotene
2387:Atrasentan
2362:Umbralisib
2357:Idelalisib
2347:Copanlisib
2329:Vorinostat
2324:Romidepsin
2314:Entinostat
2309:Belinostat
2267:Masoprocol
2255:Tiazofurin
2243:Anagrelide
2215:Bortezomib
2202:Seliciclib
2197:Ribociclib
2177:inhibitors
2167:Tipifarnib
2130:Temoporfin
2125:Talaporfin
2063:Plicamycin
2058:Mitomycins
2004:Pipobroman
1983:Hydrazines
1949:Nedaplatin
1901:Carboquone
1896:Aziridines
1887:Treosulfan
1835:Carmustine
1822:Uramustine
1791:Ifosfamide
1763:Alkylating
1724:Bisantrene
1713:Pixantrone
1686:Valrubicin
1676:Idarubicin
1671:Epirubicin
1617:Teniposide
1572:Lurtotecan
1567:Irinotecan
1468:Decitabine
1432:Cytarabine
1375:Pyrimidine
1364:Tioguanine
1354:Thiopurine
1343:Nelarabine
1327:Cladribine
1279:Pemetrexed
1262:Pemetrexed
1238:Folic acid
1178:Paclitaxel
1130:Vinflunine
463:22 October
436:References
323:autologous
257:8PX1X7UG4D
210:Schedule D
148:Drug class
2746:Phase III
2734:Withdrawn
2711:Vosaroxin
2691:Veliparib
2646:Sotorasib
2636:Selinexor
2630:Tretinoin
2620:Retinoids
2534:Glasdegib
2479:Celecoxib
2428:Adagrasib
2352:Duvelisib
2342:Alpelisib
2297:Rucaparib
2284:Niraparib
2225:Oprozomib
2187:Alvocidib
2053:Bleomycin
2010:Triazenes
1994:Etoglucid
1939:Cisplatin
1855:Nimustine
1849:Semustine
1845:Lomustine
1807:Melphalan
1734:Menogaril
1729:Crisnatol
1719:Amsacrine
1691:Zorubicin
1651:Amrubicin
1612:Etoposide
1587:Topotecan
1582:Silatecan
1577:Rubitecan
1562:Gimatecan
1547:Cositecan
1537:Belotecan
1213:inhibitor
1183:Tesetaxel
1173:Ortataxel
1168:Larotaxel
1163:Docetaxel
1125:Vindesine
932:232048693
794:1 October
627:26 August
415:Company.
378:cytopenia
346:indicated
134:Routes of
82:Monograph
76:Drugs.com
2779:Medicine
2584:Mitotane
2524:Eribulin
2292:Olaparib
2230:Ixazomib
1906:Thiotepa
1878:Busulfan
1557:Exatecan
1394:Carmofur
1102:assembly
1065: /
991:31042825
924:33626253
828:19 April
822:Archived
788:Archived
780:"Abecma"
764:29 March
758:Archived
724:29 March
718:Archived
651:Archived
621:Archived
581:29 March
575:Archived
563:"Abecma"
518:DailyMed
487:Archived
160:ATC code
118:DailyMed
42:TNFRSF17
1513:S phase
1414:Tegafur
1228:S phase
1153:Taxanes
1089:M phase
982:8202968
657:3 March
432:(INN).
395:The US
387:History
308:fatigue
222:WARNING
206: /
202::
176:)
170: (
168:L01XL07
120::
96:a621024
2765:Portal
2729:WHO-EM
2338:(Pi3K)
1295:Purine
1098:Block
989:
979:
930:
922:
493:29 May
293:Abecma
277:D11556
219:
208:
204:℞-only
116:
58:Abecma
2250:IMPDI
2145:Other
928:S2CID
818:(FDA)
814:U.S.
714:(FDA)
710:U.S.
617:(EMA)
571:(FDA)
567:U.S.
424:Names
2336:PIKI
2304:HDAC
1753:CCNS
1005:link
987:PMID
946:link
920:PMID
830:2024
796:2023
766:2021
726:2021
659:2023
629:2021
583:2021
526:2024
495:2022
465:2023
411:, a
403:and
268:KEGG
248:UNII
72:AHFS
2382:ERA
2238:PhI
2209:PrI
2174:CDK
2086:PDT
1084:MIs
1080:SPs
1071:L01
977:PMC
967:doi
963:380
910:hdl
900:doi
896:384
863:hdl
458:FDA
314:).
173:WHO
2791::
2742::
2262:LI
2162:FI
1628:II
1598:II
1420:))
1001:}}
997:{{
985:.
975:.
961:.
957:.
942:}}
938:{{
926:.
918:.
908:.
894:.
890:.
859:33
857:.
812:.
782:.
708:.
667:^
649:.
645:.
612:.
601:^
565:.
534:^
516:.
503:^
481:.
456:.
452:.
299:.
230:EU
215:US
199:CA
113:US
2767::
2632:)
2623:(
2455:)
2451:/
2447:(
2413:)
2409:(
2401:)
2397:(
2389:)
2385:(
2364:)
2340:(
2331:)
2307:(
2299:)
2277:(
2269:)
2265:(
2257:)
2253:(
2245:)
2241:(
2204:)
2180:(
2169:)
2165:(
2137:)
2118:(
2084:/
2065:)
2046:(
2027:)
2013:(
1990:)
1986:(
1898::
1889:)
1880:(
1875::
1851:)
1847:(
1832::
1813:)
1809:(
1798:)
1789:(
1774::
1755:)
1751:(
1715:)
1701:(
1693:)
1662:)
1658:(
1644:(
1630:+
1619:)
1610:(
1589:)
1535:(
1523:I
1515:)
1511:(
1495:)
1491:(
1470:)
1461:(
1451:)
1447:(
1437:)
1430:(
1416:(
1387:(
1366:)
1357:(
1339:)
1325:(
1320:/
1311:)
1307:(
1286:)
1277:(
1269:)
1250:(
1230:)
1226:(
1197:)
1193:(
1185:)
1156:(
1137:)
1113:(
1091:)
1087:(
1082:/
1073:)
1069:(
1054:e
1047:t
1040:v
1007:)
993:.
969::
948:)
934:.
912::
902::
871:.
865::
843:.
832:.
798:.
739:.
728:.
661:.
631:.
596:.
585:.
528:.
497:.
467:.
372:/
232::
217::
74:/
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