875:
493:
approximately 40 units/mg. A typical dose is 2.5U/kg every two weeks, up to a maximum of 60 U/kg once every two weeks, and safety has been established from ages 2 and up. It is one of more expensive medications, with an annual cost of $ 200,000 per person in the United States. Imiglucerase has been granted
492:
after reconstitution as a treatment for Type 1 and Type 3 Gaucher's disease. It is available in formulations containing 200 or 400 units per vial. The specific activity of highly purified human enzyme is 890,000 units/mg, meanwhile the enzyme activity produced by recombinant DNA technology is
962:
1404:
955:
948:
135:
437:
42:
671:
Starzyk K, Richards S, Yee J, Smith SE, Kingma W (February 2007). "The long-term international safety experience of imiglucerase therapy for
Gaucher disease".
532:. Less common side effects include dizziness, headache, nausea, diarrhea, and reactions at the injection site; they are found in less than 1% of patients.
93:
901:
714:(in German). Vienna: Österreichischer Apothekerverlag. 2018. Cerezyme 400 U-Pulver für ein Konzentrat zur Herstellung einer Infusionslösung.
1342:
919:
840:
Engelberg AB, Kesselheim AS, Avorn J (November 2009). "Balancing innovation, access, and profits--market exclusivity for biologics".
784:
241:
165:
74:
1414:
317:
110:
1051:
812:
604:
88:
1303:
1247:
1237:
1064:
727:"Gaucher disease: isolation and comparison of normal and mutant glucocerebrosidase from human spleen tissue"
121:
366:
1409:
1348:
1190:
998:
785:"Cerezyme Powder for concentrate for solution for infusion, Annex I: Summary of Product Characteristics"
940:
1201:
1262:
1153:
1094:
1090:
738:
458:
220:
128:
1333:
1138:
521:
485:
261:
544:
appears to increase the clearance of imiglucerase by 70%, resulting in decreased enzyme activity.
504:
Allston, Massachusetts plant, for which production was disrupted in 2009 after contamination with
1373:
1288:
1131:
1126:
1111:
1086:
653:
577:
572:
473:
469:
250:
1272:
1161:
1081:
857:
766:
688:
645:
180:
32:
628:
Weinreb NJ (August 2008). "Imiglucerase and its use for the treatment of
Gaucher's disease".
599:
1242:
1213:
972:
849:
756:
746:
680:
637:
517:
382:
270:
199:
326:
1419:
1338:
1252:
1218:
1178:
1148:
1143:
465:
207:
742:
1378:
1267:
1257:
1008:
761:
726:
520:, which occurs in about 3% of patients. It is associated with symptoms such as cough,
1398:
1308:
1230:
1018:
489:
66:
657:
52:
1383:
1368:
1363:
1106:
1023:
980:
481:
148:
143:
1353:
1195:
1166:
1116:
1074:
1028:
684:
529:
494:
427:
213:
60:
731:
Proceedings of the
National Academy of Sciences of the United States of America
641:
1328:
1293:
1183:
1171:
1102:
1056:
1046:
989:
976:
562:
421:
301:
20:
1358:
1323:
1318:
1313:
1298:
1226:
1013:
567:
556:
541:
505:
46:
861:
751:
692:
649:
853:
281:
105:
823:
770:
290:
1069:
1003:
725:
Pentchev PG, Brady RO, Blair HE, Britton DE, Sorrell SH (August 1978).
501:
1038:
525:
357:
346:
1208:
92:
337:
186:
83:
944:
174:
100:
1405:
Drugs acting on the gastrointestinal system and metabolism
444:
920:"Drug interactions between imiglucerase and miglustat"
902:"Virus shuts Genzyme plant, holds up drugs for 8,000"
540:
No clinical interaction studies have been conducted.
1281:
1037:
988:
553:Other drugs for the treatment of Gaucher's disease
497:status in the United States, Australia, and Japan.
420:
381:
376:
356:
336:
316:
300:
280:
260:
232:
219:
206:
198:
164:
159:
134:
120:
73:
59:
41:
31:
26:
484:medicine containing imiglucerase, manufactured by
269:
500:Cerezyme was one of the drugs manufactured at
956:
8:
109:
19:
963:
949:
941:
760:
750:
457:is a medication used in the treatment of
325:
900:Ailworth E, Weisman R (June 17, 2009).
813:"Cerezyme (imiglucerase for injection)"
591:
289:
246:
65:
18:
365:
51:
7:
706:
704:
702:
147:
842:The New England Journal of Medicine
345:
14:
673:Molecular Genetics and Metabolism
630:Expert Opinion on Pharmacotherapy
399:
393:
516:The most common side effect is
411:
405:
387:
1:
1052:phenylalanine ammonia-lyase
685:10.1016/j.ymgme.2006.09.003
426:55597.4 g·mol (un
1436:
820:Genzyme product data sheet
642:10.1517/14656566.9.11.1987
377:Chemical and physical data
801:– via Ec.europa.eu.
792:Sanofi-Aventis Latvia SIA
605:European Medicines Agency
434:
237:
559:(development terminated)
1304:Glycerol phenylbutyrate
1248:eladocagene exuparvovec
1238:atidarsagene autotemcel
1065:Carbohydrate metabolism
752:10.1073/pnas.75.8.3970
472:of the human enzyme β-
1349:Sodium phenylbutyrate
1343:+sodium phenylacetate
1191:iduronate-2-sulfatase
1415:Recombinant proteins
1154:Pegunigalsidase alfa
1095:Cipaglucosidase alfa
1091:Avalglucosidase alfa
854:10.1056/NEJMp0908496
129:Intravenous infusion
1139:alpha-galactosidase
743:1978PNAS...75.3970P
609:. 17 September 2018
522:shortness of breath
486:Genzyme Corporation
23:
16:Pharmaceutical drug
1374:Uridine triacetate
1289:Anethole trithione
1132:Velaglucerase alfa
1127:Taliglucerase alfa
1112:glucocerebrosidase
1087:Alglucosidase alfa
578:taliglucerase alfa
573:Velaglucerase alfa
474:glucocerebrosidase
251:glucocerebrosidase
1392:
1391:
1273:vestronidase alfa
1162:Glycosaminoglycan
1082:alpha-glucosidase
848:(20): 1917–1919.
636:(11): 1987–2000.
459:Gaucher's disease
452:
451:
190:
178:
103:
86:
1427:
1243:cerliponase alfa
1214:lysosomal lipase
1202:idursulfase beta
973:alimentary tract
965:
958:
951:
942:
935:
934:
932:
930:
916:
910:
909:
906:The Boston Globe
897:
891:
890:
888:
886:
872:
866:
865:
837:
831:
830:
828:
822:. Archived from
817:
809:
803:
802:
800:
798:
789:
781:
775:
774:
764:
754:
737:(8): 3970–3973.
722:
716:
715:
708:
697:
696:
668:
662:
661:
625:
619:
618:
616:
614:
596:
518:hypersensitivity
448:
447:
440:
413:
407:
401:
395:
389:
369:
349:
329:
293:
273:
224:
188:
185:
176:
173:
151:
113:
102:
99:
96:
85:
82:
69:
55:
24:
22:
1435:
1434:
1430:
1429:
1428:
1426:
1425:
1424:
1395:
1394:
1393:
1388:
1339:Sodium benzoate
1277:
1263:pabinafusp alfa
1253:elosulfase alfa
1219:Sebelipase alfa
1179:arylsulfatase B
1149:Agalsidase beta
1144:Agalsidase alfa
1033:
992:and derivatives
984:
969:
939:
938:
928:
926:
918:
917:
913:
899:
898:
894:
884:
882:
874:
873:
869:
839:
838:
834:
826:
815:
811:
810:
806:
796:
794:
787:
783:
782:
778:
724:
723:
719:
710:
709:
700:
670:
669:
665:
627:
626:
622:
612:
610:
600:"Cerezyme EPAR"
598:
597:
593:
588:
550:
538:
528:, itching, and
514:
466:recombinant DNA
443:
441:
438:(what is this?)
435:
416:
410:
404:
398:
392:
372:
352:
332:
312:
296:
276:
256:
253:
245:
244:
222:
200:Pharmacokinetic
194:
155:
123:
116:
17:
12:
11:
5:
1433:
1431:
1423:
1422:
1417:
1412:
1407:
1397:
1396:
1390:
1389:
1387:
1386:
1381:
1379:Velmanase alfa
1376:
1371:
1366:
1361:
1356:
1351:
1346:
1336:
1331:
1326:
1321:
1316:
1311:
1306:
1301:
1296:
1291:
1285:
1283:
1279:
1278:
1276:
1275:
1270:
1268:pegzilarginase
1265:
1260:
1258:olipudase alfa
1255:
1250:
1245:
1240:
1234:
1233:
1223:
1222:
1205:
1204:
1199:
1187:
1175:
1158:
1157:
1151:
1146:
1135:
1129:
1124:
1119:
1099:
1098:
1078:
1061:
1060:
1043:
1041:
1035:
1034:
1032:
1031:
1026:
1021:
1016:
1011:
1009:Carglumic acid
1006:
1001:
995:
993:
986:
985:
970:
968:
967:
960:
953:
945:
937:
936:
911:
892:
876:"Imiglucerase"
867:
832:
829:on 2003-06-05.
804:
776:
717:
698:
679:(2): 157–163.
663:
620:
590:
589:
587:
584:
583:
582:
581:
580:
575:
570:
565:
560:
549:
546:
537:
534:
513:
510:
488:. It is given
450:
449:
432:
431:
424:
418:
417:
414:
408:
402:
396:
390:
385:
379:
378:
374:
373:
371:
370:
362:
360:
354:
353:
351:
350:
342:
340:
334:
333:
331:
330:
322:
320:
314:
313:
311:
310:
306:
304:
298:
297:
295:
294:
286:
284:
278:
277:
275:
274:
266:
264:
258:
257:
255:
254:
248:
240:
239:
238:
235:
234:
230:
229:
226:
217:
216:
210:
204:
203:
196:
195:
193:
192:
183:
170:
168:
162:
161:
157:
156:
154:
153:
140:
138:
132:
131:
126:
124:administration
118:
117:
115:
114:
97:
79:
77:
71:
70:
63:
57:
56:
49:
39:
38:
35:
29:
28:
15:
13:
10:
9:
6:
4:
3:
2:
1432:
1421:
1418:
1416:
1413:
1411:
1408:
1406:
1403:
1402:
1400:
1385:
1382:
1380:
1377:
1375:
1372:
1370:
1367:
1365:
1362:
1360:
1357:
1355:
1352:
1350:
1347:
1344:
1340:
1337:
1335:
1332:
1330:
1327:
1325:
1322:
1320:
1317:
1315:
1312:
1310:
1309:Leriglitazone
1307:
1305:
1302:
1300:
1297:
1295:
1292:
1290:
1287:
1286:
1284:
1280:
1274:
1271:
1269:
1266:
1264:
1261:
1259:
1256:
1254:
1251:
1249:
1246:
1244:
1241:
1239:
1236:
1235:
1232:
1231:Asfotase alfa
1228:
1225:
1224:
1220:
1216:
1215:
1210:
1207:
1206:
1203:
1200:
1197:
1193:
1192:
1188:
1185:
1181:
1180:
1176:
1173:
1169:
1168:
1163:
1160:
1159:
1155:
1152:
1150:
1147:
1145:
1141:
1140:
1136:
1133:
1130:
1128:
1125:
1123:
1120:
1118:
1114:
1113:
1108:
1104:
1101:
1100:
1096:
1092:
1088:
1084:
1083:
1079:
1076:
1072:
1071:
1066:
1063:
1062:
1058:
1054:
1053:
1048:
1045:
1044:
1042:
1040:
1036:
1030:
1027:
1025:
1022:
1020:
1019:Levocarnitine
1017:
1015:
1012:
1010:
1007:
1005:
1002:
1000:
997:
996:
994:
991:
987:
982:
978:
974:
966:
961:
959:
954:
952:
947:
946:
943:
925:
921:
915:
912:
907:
903:
896:
893:
881:
877:
871:
868:
863:
859:
855:
851:
847:
843:
836:
833:
825:
821:
814:
808:
805:
793:
786:
780:
777:
772:
768:
763:
758:
753:
748:
744:
740:
736:
732:
728:
721:
718:
713:
712:Austria-Codex
707:
705:
703:
699:
694:
690:
686:
682:
678:
674:
667:
664:
659:
655:
651:
647:
643:
639:
635:
631:
624:
621:
608:
606:
601:
595:
592:
585:
579:
576:
574:
571:
569:
566:
564:
561:
558:
555:
554:
552:
551:
547:
545:
543:
535:
533:
531:
527:
523:
519:
511:
509:
507:
503:
498:
496:
491:
490:intravenously
487:
483:
479:
475:
471:
467:
462:
460:
456:
446:
439:
433:
429:
425:
423:
419:
386:
384:
380:
375:
368:
367:ChEMBL1201632
364:
363:
361:
359:
355:
348:
344:
343:
341:
339:
335:
328:
324:
323:
321:
319:
315:
308:
307:
305:
303:
299:
292:
288:
287:
285:
283:
279:
272:
268:
267:
265:
263:
259:
252:
247:
243:
236:
231:
227:
225:
218:
215:
211:
209:
205:
201:
197:
191: Rx-only
184:
182:
172:
171:
169:
167:
163:
158:
150:
145:
142:
141:
139:
137:
133:
130:
127:
125:
119:
112:
107:
98:
95:
90:
81:
80:
78:
76:
72:
68:
64:
62:
58:
54:
50:
48:
44:
40:
36:
34:
30:
27:Clinical data
25:
1410:Orphan drugs
1384:Zinc acetate
1369:Triheptanoin
1364:Tioctic acid
1212:
1189:
1177:
1165:
1137:
1122:Imiglucerase
1121:
1110:
1107:sphingolipid
1080:
1068:
1050:
1024:Mercaptamine
999:Ademetionine
927:. Retrieved
923:
914:
905:
895:
883:. Retrieved
879:
870:
845:
841:
835:
824:the original
819:
807:
795:. Retrieved
791:
779:
734:
730:
720:
711:
676:
672:
666:
633:
629:
623:
611:. Retrieved
603:
594:
539:
536:Interactions
515:
512:Side effects
499:
482:freeze-dried
477:
463:
455:Imiglucerase
454:
453:
442:
436:
428:glycosylated
228:3.6–10.4 min
221:Elimination
166:Legal status
160:Legal status
111:Imiglucerase
75:License data
21:Imiglucerase
1354:Teduglutide
1334:Sapropterin
1196:Idursulfase
1167:iduronidase
1117:Alglucerase
1075:Sacrosidase
1047:Amino acids
1029:Metreleptin
990:Amino acids
530:angiooedema
495:orphan drug
271:154248-97-2
249:Human beta-
233:Identifiers
214:proteolysis
61:MedlinePlus
33:Trade names
1399:Categories
1329:Nitisinone
1294:Eliglustat
1184:Galsulfase
1172:Laronidase
1103:Glycolipid
1057:Pegvaliase
979:products (
977:metabolism
613:18 January
586:References
563:Eliglustat
468:-produced
422:Molar mass
327:Q6U6J48BWY
302:ChemSpider
262:CAS Number
242:IUPAC name
208:Metabolism
1359:Trientine
1324:Nedosiran
1319:Miglustat
1314:Lumasiran
1299:Givosiran
1227:Phosphate
1014:Glutamine
924:Drugs.com
568:Miglustat
557:Afegostat
542:Miglustat
506:Vesivirus
502:Genzyme's
223:half-life
212:probably
122:Routes of
53:Monograph
47:Drugs.com
929:11 April
885:26 April
880:Orphanet
862:19828525
797:26 April
693:17079176
658:72183308
650:18627336
548:See also
478:Cerezyme
470:analogue
464:It is a
445:(verify)
282:DrugBank
136:ATC code
106:DailyMed
37:Cerezyme
1070:sucrase
1039:Enzymes
1004:Betaine
739:Bibcode
383:Formula
291:DB00053
152:)
146: (
144:A16AB02
108::
91::
67:a601149
1420:Sanofi
971:Other
860:
769:
762:392911
759:
691:
656:
648:
526:rashes
508:2017.
358:ChEMBL
347:D02810
181:â„ž-only
179:
104:
94:by INN
87:
1282:Other
1209:Lipid
827:(PDF)
816:(PDF)
788:(PDF)
771:29293
654:S2CID
607:(EMA)
480:is a
975:and
931:2019
887:2022
858:PMID
799:2022
767:PMID
689:PMID
646:PMID
615:2021
397:3854
391:2532
338:KEGG
318:UNII
309:none
202:data
43:AHFS
981:A16
850:doi
846:361
757:PMC
747:doi
681:doi
638:doi
409:711
403:672
149:WHO
89:EMA
1401::
1229::
1211::
1164::
1109::
1093:,
1089:,
1067::
1049::
922:.
904:.
878:.
856:.
844:.
818:.
790:.
765:.
755:.
745:.
735:75
733:.
729:.
701:^
687:.
677:90
675:.
652:.
644:.
632:.
602:.
524:,
476:.
461:.
415:16
187:EU
175:US
101:US
84:EU
1345:)
1341:(
1221:)
1217:(
1198:)
1194:(
1186:)
1182:(
1174:)
1170:(
1156:)
1142:(
1134:)
1115:(
1105:/
1097:)
1085:(
1077:)
1073:(
1059:)
1055:(
983:)
964:e
957:t
950:v
933:.
908:.
889:.
864:.
852::
773:.
749::
741::
695:.
683::
660:.
640::
634:9
617:.
430:)
412:S
406:O
400:N
394:H
388:C
189::
177::
45:/
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.