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Indocyanine green angiography

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using indocyanine green dye in monkeys. In the year 1969, using ICGA, Kogure and Choromokos studied cerebral circulation in a dog. In 1971, Hochhimer replaced color film with black and white infrared film. First human ICG angiogram was of carotid artery. First intravenous ICGA in human eye was performed by Flower and Hochheimer in 1972. In 1986 Hayashi et al. used infrared-sensitive video camera to perform ICGA. In the year 1992, Guyer et al. introduced the use of high resolution (1024 Ă— 1024) digital imaging system coupled with infrared video cameras to produce better high resolution images.
29: 2521: 155:, using ICGA multifocal areas of choroidal hyperpermiability can be visualized. In birdshoot chorioretinopathy, lesions appear as symmetrical round or oval hypoflourescent spots. ICGA allows better visualization of lesions in serpiginous chorioretinopathy, punctate inner chorioretinopathy, acute zonal occult outer retinopathy etc. In 211:
Fundus camera-based indocyanine green angiography techniques and scanning laser ophthalmoscope-based indocyanine green angiography techniques are there. The concentration of indocyanine green dye may vary according to instrument used. For fundus cameras, 25 ml ICG dissolved in 5 ml solvent is used,
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Physical and physiological properties of indocyanine green dye were first described by Fox and Wood, in 1960. Indocyanine green angiography was developed by Kodak Research Laboratories for determining cardiac output. In 1968, Kogure et al. performed intra-arterial choroidal absorption angiography
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Indocyanine green angiography has many advantages over commonly used fundus fluorescein angiography (FFA). Because of its protein-binding properties, its leakage from choriocapillaries is less and thus it will remain longer in choroidal vessels compared to fluorescein dye. Choroidal
231:. Images are taken in several second intervals until the retinal and choroidal circulations are maximally hyperfluorescent. Then for first few minutes, take photos at approximately 30 to 60 second intervals. Pictures taken are classified under three phases: 121:
in patients with exudative age-related macular degeneration. In ICGA, CNV is seen as hyperflourescent spot or plaque. It is also useful in diagnosing and classifying CNV associated to serous pigment epithelial detachments in Nonexudative macular
186:(VKH): ICGA is useful in diagnosing VKH. In VKH, delay in filling of the choriocapillaris along with larger choroidal vessel perfusion and multiple hypofluorescent spots are visible with ICGA. 241:
Late phase at 15–30 minutes: in this phase hyperfluorescent lesions appear bright against the dark background. The choroidal neovascularization are best detected in this phase.
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Mid phase at 5–15 minutes: in this phase choroidal vasculature become less distinct and more diffuse, and hyperfluorescent lesions appear bright against the fading background.
192:: Sympathetic ophthalmia is a bilateral, granulomatous form of uveitis. In sympathetic ophthalmia, numerous dark spots may be visible during the intermediate phase of ICGA. 94:
is the third main cause of blindness worldwide, and it is the leading cause of blindness in industrialized countries. Indocyanine green angiography is widely used to study
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in near-infrared (790–805 nm) range, with peak spectral absorption of 800-810 nm in blood. The near infrared light used in ICGA penetrates ocular pigments such as
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it may be increased to 50 ml in patients with poorly dilated pupil and high pigmentation. In case of iodine allergy, instead of ICG, iodine-free dye
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neovascularization is better visualized by ICGA, than fluorescein angiography. The patient toleration is also better compared to FFA.
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Anterior uveitis: ICGA is rarely indicated in anterior uveitis, but it might be used to find out associated choroidal pathology.
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in patients with exudative age-related macular degeneration. In nonexudative AMD, ICGA is used in classification of
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Andrew P., Schachat (31 May 2017). "Clinical applications of diagnostic indocyanine green angiography".
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Early phase at 60 seconds: large choroidal arteries and veins are highlighted in this phase.
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Choroidal haemangioma: ICGA can be used to differentiate choroidal haemangioma from other
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Chorioretinal atrophy: ICGA help evaluating different stages of chorioretinal atrophy.
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Principles of ocular imaging : a comprehensive guide for the eye specialist
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Stargardt disease: Numerous hypoflourescent spots are seen in ICGA.
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Albert & Jakobiec's principles and practice of ophthalmology
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Choroidal blood flow revealed with indocyanine green angiography
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Kanski's clinical ophthalmology : a systematic approach
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Indications for indocyanine green angiography include:
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Khurana, AK (31 August 2015). "Ocular therapeutics".
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Jaypee Brothers. 15 June 2010. p. 122. 1615: 858: 687: 685: 683: 681: 479:Creig S, Hoyt; David, Taylor (January 2012). 198:, to detect hypofluorescent spots around the 8: 70:) is a diagnostic procedure used to examine 2345: 2227: 2217: 1813: 1657: 1648: 1622: 1608: 1600: 1265:Descemet membrane endothelial keratoplasty 1002: 921: 865: 851: 843: 725:: CS1 maint: location missing publisher ( 299: 297: 295: 27: 777: 598:Fluorescence angiography in ophthalmology 416: 414: 412: 410: 328: 326: 324: 322: 320: 318: 2458:Orthogonal polarization spectral imaging 1471:Optical coherence tomography angiography 362: 360: 358: 356: 354: 1270:Pre-Descemet's endothelial keratoplasty 571: 569: 567: 371:(9th ed.). Elsevier. p. 431. 291: 246:Advantages over fluorescein angiography 165:Retinal angiomatous proliferation (RAP) 1154:Manual small incision cataract surgery 801:Earl A., Choromokos; Noble J., David. 718: 630: 628: 626: 531: 481:Pediatric ophthalmology and strabismus 449: 447: 445: 443: 441: 439: 437: 435: 157:multiple evanescent white dot syndrome 18: 1401:Botulinum toxin therapy of strabismus 1394:Minimally invasive strabismus surgery 827:Themes, U. F. O. (21 December 2015). 662:Clinical examination in ophthalmology 637:Comprehensive manual of ophthalmology 74:blood flow and associated pathology. 7: 1089:Phakic intraocular lens implantation 750:The British Journal of Ophthalmology 502: 500: 102:and associated subretinal deposits. 1224:Minimally invasive glaucoma surgery 49: 2265:Sestamibi parathyroid scintigraphy 367:John F, Salmon (2020). "Uveitis". 14: 1047:Intrastromal corneal ring segment 810:Journal of Ophthalmic Photography 576:Themes, U. F. O. (10 July 2016). 127:polypoidal choroidal vasculopathy 2520: 2519: 458:(6th ed.). pp. 46–76. 153:Central serous chorioretinopathy 92:Age-related macular degeneration 2022:Cholangiopancreatography (MRCP) 1022:Automated lamellar keratoplasty 746:"Indocyanine green angiography" 578:"Indocyanine Green Angiography" 305:"Indocyanine Green Angiography" 162:Pigmented epithelial detachment 2270:Radioactive iodine uptake test 1503:Bagolini Striated Glasses Test 1298:Corneal collagen cross-linking 275:Fundus fluorescein angiography 1: 2250:Radionuclide ventriculography 1724:Lower gastrointestinal series 1716:Upper gastrointestinal series 1461:Indocyanine green angiography 1456:Heidelberg Retinal Tomography 1288:Anterior chamber paracentesis 64:Indocyanine green angiography 22:Indocyanine green angiography 2441:Optical coherence tomography 2363:Myocardial perfusion imaging 1951:Dental panoramic radiography 1466:Optical coherence tomography 1345:Phototherapeutic keratectomy 1219:Excimer laser trabeculostomy 184:Vogt–Koyanagi–Harada disease 119:choroidal neovascularization 115:Choroidal neovascularisation 96:choroidal neovascularization 1094:Photorefractive keratectomy 335:Comprehensive ophthalmology 2572: 2245:Ventilation/perfusion scan 1720:Small-bowel follow-through 1513:Dilated fundus examination 1493:A-scan ultrasound biometry 1067:Laser thermal keratoplasty 890:Anesthesia for eye surgery 664:(2nd ed.). Elsevier. 2515: 2486:Dynamic angiothermography 2230: 2154:Abdominal ultrasonography 1660: 1250:Whole eye transplantation 1149:Intraocular lens scaffold 1084:Limbal relaxing incisions 939:East Asian blepharoplasty 885: 744:Owens, S L (March 1996). 50: 26: 2556:Diagnostic ophthalmology 2476:Non-contact thermography 2255:Radionuclide angiography 2107:Doppler echocardiography 2260:Radioisotope renography 1446:Fluorescein angiography 1293:Boston keratoprosthesis 1255:Corneal transplantation 1027:Conductive keratoplasty 393:"Priority eye diseases" 2295:Gastric emptying study 1325:Intravitreal injection 1189:Laser photocoagulation 1134:Glued intraocular lens 660:PK, Mukherjee (2016). 538:: CS1 maint: others ( 190:Sympathetic ophthalmia 151:Chorioretinopathy: In 1956:X-ray motion analysis 1839:X-ray microtomography 1758:Hysterosalpingography 1665:Pneumoencephalography 1543:Slit-lamp examination 1508:Color perception test 1431:Electronystagmography 979:Dacryocystorhinostomy 729:) CS1 maint: others ( 2481:Contact thermography 2191:Emergency ultrasound 2129:Transcranial Doppler 1880:Abdominal and pelvis 1384:Harada–Ito procedure 1057:Laser blended vision 762:10.1136/bjo.80.3.263 595:Dithmar, S. (2008). 16:Diagnostic procedure 2448:Confocal microscopy 2326:Indium-111 WBC scan 2149:Echoencephalography 1885:Virtual colonoscopy 1568:Plaque radiotherapy 1441:Electroretinography 1159:Phacoemulsification 456:Ryan's retina Vol 1 134:choroidal melanomas 2436:Optical tomography 2285:Dacryoscintigraphy 2280:Immunoscintigraphy 1919:Whole body imaging 1670:Dental radiography 1451:Fundus photography 1436:Electrooculography 1421:Corneal topography 1389:Strabismus surgery 403:on March 22, 2006. 270:Fundus photography 214:Infracyanine green 140:intraocular tumors 2533: 2532: 2495:Target conditions 2418: 2417: 2414: 2413: 2334: 2333: 2275:Bone scintigraphy 2240:Scintimammography 2235:Cholescintigraphy 2080:contrast-enhanced 1974: 1973: 1934: 1933: 1924:Full-body CT scan 1824:General operation 1803: 1802: 1773:Angiocardiography 1597: 1596: 1548:Visual field test 1368: 1367: 1099:Radial keratotomy 1062:Laser eye surgery 992: 991: 704:978-1-63091-600-8 671:978-81-312-4463-0 646:978-93-5025-175-1 608:978-3-540-79401-1 517:978-1-336-22997-6 465:978-0-323-40197-5 378:978-0-7020-7711-1 344:978-93-5152-657-5 219:To perform test, 76:Indocyanine green 61: 60: 2563: 2523: 2522: 2346: 2228: 2218: 2102:Echocardiography 1961:Hounsfield scale 1814: 1733:Cholecystography 1658: 1649: 1624: 1617: 1610: 1601: 1528:Ocular tonometry 1426:Electrodiagnosis 1214:Cyclodestruction 1139:Hydrodelineation 1003: 956:Hughes procedure 922: 867: 860: 853: 844: 837: 836: 824: 818: 817: 807: 798: 792: 791: 781: 741: 735: 734: 724: 716: 689: 676: 675: 657: 651: 650: 632: 621: 620: 592: 586: 585: 573: 562: 561: 550: 544: 543: 537: 529: 504: 495: 494: 476: 470: 469: 451: 430: 429: 418: 405: 404: 399:. 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2263: 2261: 2258: 2256: 2253: 2251: 2248: 2246: 2243: 2241: 2238: 2236: 2233: 2232: 2229: 2226: 2224: 2219: 2216: 2214: 2210: 2202: 2199: 2197: 2194: 2193: 2192: 2189: 2187: 2184: 2182: 2179: 2177: 2174: 2172: 2169: 2165: 2162: 2160: 2157: 2156: 2155: 2152: 2150: 2147: 2145: 2142: 2140: 2137: 2135: 2134:Intravascular 2132: 2130: 2127: 2123: 2120: 2118: 2115: 2113: 2110: 2108: 2105: 2104: 2103: 2100: 2096: 2093: 2091: 2088: 2086: 2083: 2081: 2078: 2076: 2073: 2072: 2070: 2069: 2067: 2065: 2061: 2055: 2054:Synthetic MRI 2052: 2048: 2045: 2043: 2040: 2038: 2035: 2034: 2033: 2030: 2028: 2025: 2023: 2020: 2018: 2015: 2011: 2008: 2007: 2006: 2003: 2001: 1998: 1994: 1991: 1990: 1989: 1986: 1985: 1983: 1981: 1977: 1967: 1964: 1962: 1959: 1957: 1954: 1952: 1949: 1947: 1944: 1943: 1941: 1937: 1925: 1922: 1921: 1920: 1917: 1915: 1912: 1910: 1907: 1903: 1900: 1898: 1895: 1894: 1893: 1890: 1886: 1883: 1882: 1881: 1878: 1874: 1871: 1869: 1866: 1865: 1863: 1862: 1860: 1856: 1850: 1847: 1845: 1844:Electron beam 1842: 1840: 1837: 1835: 1832: 1830: 1827: 1825: 1822: 1821: 1819: 1815: 1812: 1810: 1806: 1796: 1795:Orbital x-ray 1793: 1791: 1788: 1786: 1783: 1779: 1776: 1774: 1771: 1770: 1769: 1766: 1764: 1761: 1759: 1756: 1754: 1751: 1749: 1746: 1744: 1741: 1739: 1736: 1734: 1730: 1727: 1725: 1721: 1717: 1714: 1712: 1708: 1705: 1703: 1700: 1698: 1695: 1691: 1690:Bronchography 1688: 1687: 1686: 1683: 1681: 1678: 1676: 1673: 1671: 1668: 1666: 1663: 1662: 1659: 1656: 1654: 1650: 1647: 1645: 1640: 1636: 1632: 1625: 1620: 1618: 1613: 1611: 1606: 1605: 1602: 1590: 1587: 1585: 1582: 1581: 1579: 1575: 1569: 1566: 1565: 1563: 1561: 1555: 1549: 1546: 1544: 1541: 1539: 1536: 1534: 1531: 1529: 1526: 1524: 1521: 1519: 1516: 1514: 1511: 1509: 1506: 1504: 1501: 1499: 1496: 1494: 1491: 1490: 1488: 1486: 1480: 1472: 1469: 1468: 1467: 1464: 1462: 1459: 1457: 1454: 1452: 1449: 1447: 1444: 1442: 1439: 1437: 1434: 1432: 1429: 1427: 1424: 1422: 1419: 1418: 1416: 1414: 1408: 1402: 1399: 1395: 1392: 1391: 1390: 1387: 1385: 1382: 1381: 1379: 1377: 1371: 1361: 1358: 1356: 1353: 1351: 1348: 1346: 1343: 1341: 1338: 1336: 1333: 1331: 1328: 1326: 1323: 1321: 1318: 1316: 1313: 1309: 1306: 1305: 1304: 1301: 1299: 1296: 1294: 1291: 1289: 1286: 1285: 1283: 1279: 1271: 1268: 1266: 1263: 1261: 1258: 1257: 1256: 1253: 1251: 1248: 1247: 1245: 1241: 1235: 1232: 1230: 1227: 1225: 1222: 1220: 1217: 1215: 1212: 1211: 1209: 1207: 1201: 1195: 1192: 1190: 1187: 1185: 1182: 1181: 1179: 1173: 1165: 1162: 1161: 1160: 1157: 1155: 1152: 1150: 1147: 1145: 1142: 1140: 1137: 1135: 1132: 1130: 1127: 1125: 1124:Capsulorhexis 1122: 1121: 1119: 1117: 1111: 1105: 1102: 1100: 1097: 1095: 1092: 1090: 1087: 1085: 1082: 1078: 1075: 1074: 1073: 1070: 1068: 1065: 1063: 1060: 1058: 1055: 1053: 1050: 1048: 1045: 1043: 1040: 1038: 1035: 1033: 1032:Corneal inlay 1030: 1028: 1025: 1023: 1020: 1018: 1017:Alpins method 1015: 1014: 1012: 1010: 1004: 1001: 999: 995: 985: 982: 980: 977: 976: 974: 972: 968: 962: 959: 957: 954: 952: 949: 947: 944: 940: 937: 936: 935: 932: 931: 929: 927: 923: 920: 918: 914: 908: 905: 901: 900:Oculoplastics 898: 897: 896: 893: 891: 888: 887: 884: 880: 876: 868: 863: 861: 856: 854: 849: 848: 845: 834: 833:Radiology Key 830: 823: 820: 815: 811: 804: 797: 794: 789: 785: 780: 775: 771: 767: 763: 759: 755: 751: 747: 740: 737: 732: 728: 722: 714: 710: 706: 700: 696: 695: 688: 686: 684: 682: 678: 673: 667: 663: 656: 653: 648: 642: 638: 631: 629: 627: 623: 618: 614: 610: 604: 600: 599: 591: 588: 583: 579: 572: 570: 568: 564: 559: 555: 549: 546: 541: 535: 527: 523: 519: 513: 509: 503: 501: 497: 492: 490:9780702046919 486: 482: 475: 472: 467: 461: 457: 450: 448: 446: 444: 442: 440: 438: 436: 432: 427: 423: 417: 415: 413: 411: 407: 402: 398: 394: 388: 385: 380: 374: 370: 363: 361: 359: 357: 355: 351: 346: 340: 336: 329: 327: 325: 323: 321: 319: 315: 310: 306: 300: 298: 296: 292: 285: 281: 278: 276: 273: 271: 268: 267: 263: 261: 254: 252: 245: 240: 237: 234: 233: 232: 230: 226: 222: 217: 215: 206: 201: 197: 194: 191: 188: 185: 182: 179: 176: 173: 170: 167: 164: 161: 158: 154: 150: 147: 144: 141: 137: 135: 131: 128: 124: 122:degeneration. 120: 116: 113: 112: 111: 105: 103: 101: 97: 93: 89: 85: 81: 77: 73: 69: 65: 55: 46: 43: 41: 37: 30: 25: 20: 2502:Acute stroke 2468:Thermography 2223:scintigraphy 2213:Radionuclide 2201:pre-hospital 2047:Tractography 1966:Radiodensity 1868:calcium scan 1829:Quantitative 1460: 1315:Evisceration 1184:Ignipuncture 984:Punctoplasty 961:Tarsorrhaphy 832: 822: 813: 809: 796: 753: 749: 739: 693: 661: 655: 636: 597: 590: 581: 557: 548: 507: 480: 474: 455: 425: 401:the original 396: 387: 368: 334: 308: 258: 249: 218: 210: 202:and arcades. 109: 80:fluorescence 67: 63: 62: 2391:Cardiac PET 2164:renal tract 2139:Gynecologic 2071:Techniques 2042:restriction 2017:Angiography 2000:Neurography 1946:Fluoroscopy 1892:Angiography 1873:angiography 1817:Techniques: 1778:Aortography 1768:Angiography 1748:Cystography 1738:Mammography 1680:Myelography 1675:Sialography 1644:radiography 1538:Retinoscopy 1498:Amsler grid 1485:examination 1374:Extraocular 1303:Enucleation 1129:Capsulotomy 895:Eye surgery 397:www.who.int 309:www.aao.org 146:Choroiditis 125:Idiopathic 106:Indications 88:xanthophyll 2540:Categories 2304:Full body: 2090:endoscopic 2064:Ultrasound 1993:functional 1790:Lymphogram 1785:Venography 1753:Arthrogram 1523:Gonioscopy 1518:Funduscopy 1360:Vitrectomy 1355:Sclerotomy 1330:Iridectomy 1007:Refractive 875:procedures 873:Tests and 713:1259320518 286:References 200:optic disc 132:Pigmented 2507:Pregnancy 2386:Brain PET 2354:gamma ray 2290:DMSA scan 2144:Obstetric 2037:diffusion 2032:Sequences 2010:perfusion 1902:Pulmonary 1849:Cone beam 1743:Pyelogram 1558:Radiation 1350:Pterygium 1308:Conformer 1042:Epi-LASIK 770:0007-1161 721:cite book 617:288578300 534:cite book 526:489078723 207:Procedure 72:choroidal 2525:Category 2377:positron 1897:Coronary 1584:Couching 1335:Peritomy 1204:Glaucoma 1114:Cataract 582:Ento Key 264:See also 40:ICD-9-CM 2424:Optical 2406:PET-MRI 2186:Carotid 2181:Scrotal 2075:doppler 2005:Cardiac 1914:Thyroid 1858:Targets 1809:CT scan 1577:History 1560:therapy 1413:imaging 1411:Medical 1376:muscles 1206:surgery 1177:surgery 1175:Retinal 1164:Prechop 1116:surgery 1009:surgery 926:Eyelids 788:8703866 255:History 84:melanin 2401:PET-CT 2176:Breast 2171:Rectal 2095:duplex 2027:Breast 1864:Heart 917:Adnexa 786:  779:505439 776:  768:  711:  701:  668:  643:  615:  605:  524:  514:  487:  462:  375:  341:  129:(IPCV) 100:drusen 2428:Laser 2350:SPECT 2159:renal 1988:Brain 1939:Other 1639:X-ray 1281:Other 1104:SMILE 1072:LASIK 998:Globe 816:: 70. 806:(PDF) 229:bolus 221:pupil 52:[ 45:95.11 2196:FAST 1909:Head 879:eyes 784:PMID 766:ISSN 731:link 727:link 709:OCLC 699:ISBN 666:ISBN 641:ISBN 613:OCLC 603:ISBN 540:link 522:OCLC 512:ISBN 485:ISBN 460:ISBN 373:ISBN 339:ISBN 86:and 68:ICGA 2373:PET 2341:ECT 2339:3D/ 2221:2D/ 2122:ICE 2117:TEE 2112:TTE 1980:MRI 1711:DXR 1707:DXA 1702:KUB 1697:AXR 1685:CXR 1483:Eye 774:PMC 758:doi 227:as 2542:: 2379:): 2356:): 2085:3D 1653:2D 831:. 814:16 812:. 808:. 782:. 772:. 764:. 754:80 752:. 748:. 723:}} 719:{{ 707:. 680:^ 625:^ 611:. 580:. 566:^ 556:. 536:}} 532:{{ 520:. 499:^ 434:^ 424:. 409:^ 395:. 353:^ 317:^ 307:. 294:^ 2426:/ 2375:( 2352:( 1731:/ 1722:/ 1718:/ 1709:/ 1641:/ 1623:e 1616:t 1609:v 866:e 859:t 852:v 835:. 790:. 760:: 733:) 715:. 674:. 649:. 619:. 584:. 560:. 542:) 528:. 493:. 468:. 428:. 381:. 347:. 311:. 142:. 66:( 56:]

Index


ICD-9-CM
95.11
edit on Wikidata
choroidal
Indocyanine green
fluorescence
melanin
xanthophyll
Age-related macular degeneration
choroidal neovascularization
drusen
Choroidal neovascularisation
choroidal neovascularization
polypoidal choroidal vasculopathy
choroidal melanomas
intraocular tumors
Choroiditis
Central serous chorioretinopathy
multiple evanescent white dot syndrome
Angioid streaks
Vogt–Koyanagi–Harada disease
Sympathetic ophthalmia
Acute idiopathic blind spot enlargement syndrome
optic disc
Infracyanine green
pupil
antecubital vein
bolus
Fundus photography

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