329:
286:
188:
51:
328:
1238:
Spirito, Lorenzo; Manfredi, Celeste; La Rocca, Roberto; Napolitano, Luigi; Di
Girolamo, Antonio; Capece, Marco; Trama, Francesco; Sciorio, Carmine; Sokolakis, Ioannis; Creta, Massimiliano; Arcaniolo, Davide (2022). "Daily low-dose tadalafil may reduce the penile curvature progression rate in patients
418:
The overall prevalence of PD is about 1–20% in men. Rates range from 3.2 percent in a community-based survey of 4432 men (mean age of sample 57.4) to 16 percent among 488 men undergoing evaluation for erectile dysfunction (mean age 52.8). The prevalence of PD among the 4432 men in the community based
313:
focal thickening of the tunica albuginea. Due to associated calcifications, the imaging of patients with
Peyronie's disease shows acoustic shadowing, as illustrated in figures below. Less common findings, attributed to earlier stages of the disease (still mild fibrosis), are hypoechoic lesions with
321:
In the
Doppler study, increased flow around the plaques can suggest inflammatory activity and the absence of flow can suggest disease stability. Ultrasound is useful for the identification of lesions and to determine their relationship with the neurovascular bundle. Individuals with Peyronie's
419:
study who responded by self report positively for palpable plaque, newly occurring angulation or curvature and painful erection was 1.5 percent between the ages of 30 and 39, 3 percent between 40 and 49, 3 percent between 50 and 59, 4 percent between 60 and 69, and 6.5 percent over 70.
1455:
Mulhall, John P.; Creech, Steven D.; Boorjian, Stephen A.; Ghaly, SAM; Kim, Edward D.; Moty, Ayham; Davis, Rodney; Hellstrom, Wayne (2004). "Subjective and
Objective Analysis of the Prevalence of Peyronie's Disease in a Population of Men Presenting for Prostate Cancer Screening".
322:
disease can present with erectile dysfunction, often related to venous leakage, due to insufficient drainage at the site of the plaque. Although plaques are more common on the dorsum of the penis, they can also be seen on the ventral face, lateral face, or septum.
422:
In 534 men undergoing routine prostate screening for cancer detection (without a specific urologic complaint), the prevalence of PD was 8.9 percent. In this study, the mean age of those with PD was 68.2 years compared with 61.8 years of those without PD.
212:
painful and/or difficult, though it is unclear whether some men report satisfactory or unsatisfactory intercourse in spite of the disorder. The disorder is confined to the penis, although a substantial number of men with
Peyronie's exhibit concurrent
381:
There is moderate evidence that penile traction therapy is a well-tolerated, minimally invasive treatment; there is uncertainty about the optimal duration of stretching per day and per course of treatment, and the treatment course is difficult.
1632:
1617:
334:
Transverse ultrasound of the penis, in a ventral view, in the middle portion of the penis. Note the echoic image with posterior acoustic shadowing, corresponding to calcification (arrow), in the left corpus cavernosum.
195:
A certain degree of curvature of the penis is considered normal, as many people are born with this benign condition, commonly referred to as congenital curvature. The disease may cause pain; hardened, big, cord-like
245:
The underlying cause of
Peyronie's disease is unknown. Although, it is likely due to a buildup of plaque inside the penis due to repeated mild sexual trauma or injury during sexual intercourse or physical activity.
207:
Although the popular conception of
Peyronie's disease is that it always involves curvature of the penis, the scar tissue sometimes causes divots or indentations rather than curvature. The condition may also make
1754:
414:
It is estimated to affect 1–20% of men. The condition becomes more common with age. The mean age at onset of disease is 55–60 years although many cases have been recorded in adolescence and early 20's.
289:
This ultrasound depicts cross sections of the penis at different locations in a patient with
Peyronie's disease. The top image shows normal anatomy whereas the bottom image shows scar tissue on the
297:
A urologist may be able to diagnose the disease and suggest treatment. An ultrasound can provide conclusive evidence of
Peyronie's disease, ruling out congenital curvature or other disorders.
1999:
356:
supplementation has been studied for decades, and some success has been reported in older trials; those successes have not been reliably repeated in larger, newer studies. The use of
1747:
1483:
Kadioglu, A.; Oktar, T.; Kandirali, E.; Kendirci, M.; Sanli, O.; Ozsoy, C. (2004). "Incidentally diagnosed
Peyronie's disease in men presenting with erectile dysfuntion".
1740:
1922:
1224:
233:
Peyronie's disease can also have psychological effects. While most men will continue to be able to have sexual relations, they are likely to experience some degree of
780:
Hatzimouratidisa, Konstantinos; Eardley, Ian; Giuliano, François; Hatzichristou, Dimitrios; Moncada, Ignacio; Salonia, Andrea; Vardi, Yoram; Wespes, Eric (2012).
402:), is considered a last resort and should only be performed by highly skilled urological surgeons knowledgeable in specialized corrective surgical techniques. A
877:
Amin Z, Patel U, Friedman EP, Vale JA, Kirby R, Lees WR (May 1993). "Colour Doppler and duplex ultrasound assessment of Peyronie's disease in impotent men".
2143:
591:
2138:
702:
350:
Many oral treatments have been studied but results so far have been mixed. Some consider the use of nonsurgical approaches to be controversial.
366:
is reported to help by breaking down the excess collagen in the penis. It was approved for treatment of Peyronie's disease by the FDA in 2013.
1927:
603:
469:
1192:
748:
363:
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1647:
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focal thickening of the paracavernous tissues, echoic focal thickening of the tunica without posterior acoustic shadowing, retractile
225:
of the hand. An increased incidence in genetically related males suggests a genetic component. It can affect men of any race and age.
1202:
758:
574:
498:
619:
Carrieri MP, Serraino D, Palmiotto F, Nucci G, Sasso F (June 1998). "A case-control study on risk factors for Peyronie's disease".
440:
141:
562:
1020:
Hauck EW, Diemer T, Schmelz HU, Weidner W (June 2006). "A critical analysis of nonsurgical treatment of Peyronie's disease".
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293:. The scar tissue is localized and responsible for the hallmark deformities of Peyronie's disease (curvature and narrowing).
1166:
2117:
1917:
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1992:
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200:(scar tissue known as "plaques"); or abnormal curvature of the penis when erect due to chronic inflammation of the
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lesions with posterior attenuation of the beam, and focal loss of the continuity of the tunica albuginea.
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in the hand, and to a lesser degree, in the feet. About 30 percent of men with Peyronie's disease develop
781:
917:
Fernandes, Maitê Aline Vieira; Souza, Luis Ronan Marquez Ferreira de; Cartafina, Luciano Pousa (2018).
1406:
2027:
1763:
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234:
173:
44:
Peyronie disease, induratio penis plastica (IPP), chronic inflammation of the tunica albuginea (CITA)
1636:
1560:
Gabrielis Falloppii medici Mutinensis Observationes anatomicae ad Petrum Mannam medicum Cremonensem
357:
285:
2034:
2022:
1809:
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1317:"Penile traction therapy and Peyronie's disease: a state of art review of the current literature"
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729:
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in the early stages of the disease has been studied; as of 2007, its efficacy was questionable.
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1522:(October 1996). "Francois de LaPeyronie (1978-1747): the man and the disease he described".
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Nelson CJ, Mulhall JP (March 2013). "Psychological impact of Peyronie's disease: a review".
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537:
432:
71:
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2049:
1957:
1949:
1939:
1096:
Trost LW, Gur S, Hellstrom WJ (2007). "Pharmacological Management of Peyronie's Disease".
266:
262:
1594:
526:"Peyronie's disease and erectile dysfunction: Current understanding and future direction"
1579:
17:
1861:
1641:
1405:
Tal, Raanan; Hall, Matthew S.; Alex, Byron; Choi, Judy; Mulhall, John P. (2012-01-01).
1341:
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237:. It is not uncommon to exhibit depression or withdrawal from their sexual partners.
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It is estimated to affect 1–20% of men. The condition becomes more common with age.
2012:
1884:
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1284:"Pd21-09 Daily Tadalafil Therapy: A New Treatment Option for Peyronie's Disease?"
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890:
797:
1978:
1907:
1839:
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1704:
1563:. U.S. National Library of Medicine. Venetiis : Apud Marcum Antonium Vlmum.
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161:
157:
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50:
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58:
Man showing abnormal curvature of the penis associated with Peyronie's disease
1430:
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in other elastic tissues of the body, such as on the hand or foot, including
1986:
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464:(6th ed.). New York: McGraw-Hill, Medical Pub. Division. p. 990.
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2017:
2007:
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1819:
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844:
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with acute Peyronie's disease: a retrospective comparative analysis".
1767:
1621:
197:
136:
565:. In Graham, Sam D.; Keane, Thomas E.; Glenn, James Francis (eds.).
431:
The condition was first described in 1561 in correspondence between
828:"Peyronie's disease: evaluation and review of nonsurgical therapy"
284:
186:
1191:
Giorgio Pajardi, Marie A. Badalamente, Lawrence C. Hurst (2018).
439:
and separately by Gabriele Falloppio. The condition is named for
1685:
1652:
981:"Review of current nonsurgical management of Peyronie's disease"
750:
Contemporary Treatment of Erectile Dysfunction: A Clinical Guide
503:
National Institute of Diabetes and Digestive and Kidney Diseases
1736:
1167:"Injections to Treat an Embarrassing Ailment Win U.S. Approval"
1366:"Surgical approaches for advanced Peyronie's disease patients"
92:
390:
Surgery such as the "Nesbit operation", which is named after
83:
77:
1140:"FDA approves first drug treatment for Peyronie's disease"
2000:
Pseudoepitheliomatous keratotic and micaceous balanitis
1282:
Park*, Hyun Jun; Park, Sung Woo; Kim, Tae Nam (2019).
910:
908:
89:
1599:
1146:. U.S. Food and Drug Administration. 6 December 2013
460:
Freedberg, Irwin M.; Fitzpatrick, Thomas B. (2003).
80:
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62:
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569:. Lippincott Williams & Wilkins. p. 533.
1923:Chronic prostatitis/chronic pelvic pain syndrome
373:in treating the disease have also been studied.
1595:Medscape Urology overview of Peyronie's disease
826:Abern, Michael R.; Levine, Laurence A. (2009).
156:involving the growth of fibrous plaques in the
27:Abnormal growth of scar tissue within the penis
691:
689:
687:
1748:
1450:
1448:
462:Fitzpatrick's dermatology in general medicine
176:, indentation, loss of girth and shortening.
168:, the thick sheath of tissue surrounding the
8:
1223:: CS1 maint: multiple names: authors list (
1485:International Journal of Impotence Research
1370:International Journal of Impotence Research
1241:International Journal of Impotence Research
1061:International Journal of Impotence Research
985:International Journal of Impotence Research
1974:
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747:Tobias S. Köhler, Kevin T. McVary (2016).
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32:
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696:Ralph, D. J.; Minhas, S. (January 2004).
541:
493:
491:
489:
487:
485:
483:
481:
164:. Specifically, scar tissue forms in the
703:British Journal of Urology International
594:. In Kumar, Anand; Sharma, Mona (eds.).
499:"Penile Curvature (Peyronie's Disease)"
452:
324:
1364:Hellstrom WJ, Usta MF (October 2003).
1216:
698:"The management of Peyronie's disease"
406:may be appropriate in advanced cases.
191:Example of penis deformation from side
1928:Asymptomatic inflammatory prostatitis
1057:"Oral therapy for Peyronie's disease"
1055:Mynderse LA, Monga M (October 2002).
596:Basics of Human Andrology: A Textbook
7:
1987:Balanoposthitis / Balanitis
1165:Pollack, Andrew (December 6, 2013).
919:"Ultrasound evaluation of the penis"
782:"EAU guidelines on penile curvature"
598:. New Delhi: Springer. p. 268.
364:Collagenase clostridium histolyticum
172:, causing pain, abnormal curvature,
2060:Persistent genital arousal disorder
590:Kumar, Anand; Sharma, Mona (2017).
1315:Eric C, Geralb B (February 2013).
25:
1470:10.1097/01.ju.0000127744.18878.f1
1407:"Peyronie's Disease in Teenagers"
1301:10.1097/01.JU.0000555753.36349.5d
2144:Diseases named after discoverers
1536:10.1046/j.1464-410x.1996.14120.x
1423:10.1111/j.1743-6109.2011.02502.x
1194:Collagenase in Dupuytren Disease
1110:10.2165/00003495-200767040-00004
879:The British Journal of Radiology
717:10.1111/j.1464-410X.2004.04587.x
670:10.1111/j.1743-6109.2012.02999.x
621:Journal of Clinical Epidemiology
327:
70:
2139:Dermal and subcutaneous growths
1411:The Journal of Sexual Medicine
657:The Journal of Sexual Medicine
1:
2118:Postorgasmic illness syndrome
2055:Balanitis xerotica obliterans
1918:Chronic bacterial prostatitis
633:10.1016/S0895-4356(98)00015-8
441:François Gigot de la Peyronie
271:excessive alcohol consumption
142:François Gigot de la Peyronie
1935:Benign prostatic hyperplasia
1557:Falloppio, Gabriele (1561).
1034:10.1016/j.eururo.2006.02.059
891:10.1259/0007-1285-66-785-398
832:The Scientific World Journal
798:10.1016/j.eururo.2012.05.040
443:, who described it in 1743.
377:Physical therapy and devices
309:, the typical appearance is
935:10.1590/0100-3984.2016.0152
524:Levine, Laurence A (2010).
215:connective tissue disorders
2170:
1993:Balanitis plasmacellularis
1253:10.1038/s41443-022-00651-8
979:Levine LA (October 2003).
592:"15. Male Sexual Function"
563:"81. Congenital Curvature"
346:Medication and supplements
154:connective tissue disorder
530:Indian Journal of Urology
394:(1898–1979), an American
277:, and European heritage.
57:
48:
1333:10.1177/1756287212454932
567:Glenn's Urologic Surgery
291:tunica albuginea (penis)
18:Induratio penis plastica
1497:10.1038/sj.ijir.3901247
1464:(6 Part 1): 2350–2353.
1383:10.1038/sj.ijir.3901085
1074:10.1038/sj.ijir.3900869
998:10.1038/sj.ijir.3901084
914:Originally copied from:
543:10.4103/0970-1591.27633
255:Dupuytren's contracture
223:Dupuytren's contracture
2113:Retrograde ejaculation
400:University of Michigan
307:penile ultrasonography
294:
275:genetic predisposition
192:
923:Radiologia Brasileira
288:
249:Risk factors include
190:
2028:Erectile dysfunction
991:(Suppl 5): S113–20.
259:plantar fibromatosis
235:erectile dysfunction
174:erectile dysfunction
1958:Seminal vesiculitis
1376:(Suppl 5): S121–4.
845:10.1100/tsw.2009.92
358:Interferon-alpha-2b
2040:Peyronie's disease
2035:Spontaneous orgasm
2023:Sexual dysfunction
1810:Testicular torsion
1696:External resources
1575:Peyronie's disease
1458:Journal of Urology
1288:Journal of Urology
437:Gabriele Falloppio
295:
210:sexual intercourse
193:
183:Signs and symptoms
150:Peyronie's disease
36:Peyronie's disease
2126:
2125:
2096:
2095:
2078:Fournier gangrene
1966:
1965:
1913:Acute prostatitis
1825:Asthenozoospermia
1805:Testicular cancer
1730:
1729:
605:978-981-10-3694-1
559:McCammon, Kurt A.
471:978-0-07-138076-8
251:diabetes mellitus
170:corpora cavernosa
147:
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30:Medical condition
16:(Redirected from
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1975:
1815:Male infertility
1800:Hydrocele testis
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1491:(6): 540–543.
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904:
869:
838:(9): 665–675.
818:
792:(3): 543–552.
772:
759:
739:
683:
646:
611:
604:
582:
575:
549:
516:
477:
470:
451:
450:
448:
445:
428:
425:
411:
408:
404:penile implant
392:Reed M. Nesbit
387:
384:
378:
375:
347:
344:
342:
339:
338:
337:
333:
326:
302:
299:
282:
279:
242:
239:
230:
227:
184:
181:
145:
144:
139:
133:
132:
129:
125:
124:
121:
117:
116:
111:
105:
104:
102:
101:
66:
64:
60:
59:
55:
54:
46:
45:
42:
38:
37:
29:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2166:
2155:
2154:Sexual health
2152:
2150:
2147:
2145:
2142:
2140:
2137:
2136:
2134:
2119:
2116:
2114:
2111:
2109:
2108:Hematospermia
2106:
2105:
2103:
2099:
2089:
2088:Pneumoscrotum
2086:
2084:
2081:
2079:
2076:
2075:
2073:
2071:
2067:
2061:
2058:
2056:
2053:
2051:
2048:
2046:
2045:Penile cancer
2043:
2041:
2038:
2036:
2033:
2029:
2026:
2025:
2024:
2021:
2019:
2016:
2014:
2011:
2009:
2006:
2002:
2001:
1997:
1995:
1994:
1990:
1989:
1988:
1985:
1984:
1982:
1980:
1976:
1973:
1969:
1959:
1956:
1955:
1953:
1951:
1947:
1941:
1938:
1936:
1933:
1929:
1926:
1924:
1921:
1919:
1916:
1914:
1911:
1910:
1909:
1906:
1905:
1903:
1901:
1897:
1891:
1888:
1886:
1883:
1881:
1878:
1877:
1875:
1873:
1869:
1863:
1860:
1856:
1855:Teratospermia
1853:
1851:
1848:
1846:
1843:
1841:
1838:
1836:
1833:
1831:
1828:
1826:
1823:
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1808:
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1803:
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1798:
1796:
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1790:
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1784:
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1773:
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1765:
1764:Male diseases
1758:
1753:
1751:
1746:
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1739:
1738:
1735:
1722:
1718:
1717:
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1581:
1580:Who Named It?
1577:
1576:
1570:
1567:
1562:
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1553:
1550:
1545:
1541:
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1533:
1530:(4): 613–22.
1529:
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1521:
1518:Dunsmuir WD,
1514:
1511:
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1498:
1494:
1490:
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1479:
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1471:
1467:
1463:
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1343:
1338:
1334:
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1321:Ther Adv Urol
1318:
1311:
1308:
1302:
1297:
1293:
1289:
1285:
1278:
1275:
1270:
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1200:
1196:
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1145:
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1135:
1132:
1127:
1123:
1119:
1115:
1111:
1107:
1104:(4): 527–45.
1103:
1099:
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1080:
1075:
1070:
1066:
1062:
1058:
1051:
1048:
1043:
1039:
1035:
1031:
1028:(6): 987–97.
1027:
1023:
1016:
1013:
1008:
1004:
999:
994:
990:
986:
982:
975:
972:
968:
962:
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861:
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851:
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791:
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783:
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762:
760:9783319315874
756:
752:
751:
743:
740:
735:
731:
727:
723:
718:
713:
710:(2): 208–15.
709:
705:
704:
699:
692:
690:
688:
684:
679:
675:
671:
667:
664:(3): 653–60.
663:
659:
658:
650:
647:
642:
638:
634:
630:
626:
622:
615:
612:
607:
601:
597:
593:
586:
583:
578:
576:9780781791410
572:
568:
564:
560:
553:
550:
544:
539:
536:(3): 246–50.
535:
531:
527:
520:
517:
504:
500:
494:
492:
490:
488:
486:
484:
482:
478:
473:
467:
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456:
453:
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442:
438:
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330:
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323:
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317:
312:
308:
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292:
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280:
278:
276:
272:
268:
264:
263:penile trauma
260:
256:
252:
247:
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236:
228:
226:
224:
220:
216:
211:
205:
203:
199:
189:
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143:
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138:
134:
130:
126:
122:
118:
115:
112:
110:
106:
97:
68:
67:
65:
63:Pronunciation
61:
56:
52:
47:
43:
39:
34:
19:
2039:
2013:Paraphimosis
1998:
1991:
1885:Spermatocele
1880:Epididymitis
1850:Necrospermia
1845:Oligospermia
1835:Hyperspermia
1714:
1703:
1679:
1668:
1657:
1646:
1631:
1616:
1573:
1569:
1559:
1552:
1527:
1523:
1513:
1488:
1484:
1478:
1461:
1457:
1414:
1410:
1400:
1373:
1369:
1359:
1327:(2): 59–65.
1324:
1320:
1310:
1291:
1287:
1277:
1244:
1240:
1233:
1208:. Retrieved
1197:. Springer.
1193:
1186:
1174:. Retrieved
1170:
1160:
1148:. Retrieved
1143:
1134:
1101:
1097:
1091:
1067:(5): 340–4.
1064:
1060:
1050:
1025:
1021:
1015:
988:
984:
974:
926:
922:
882:
878:
872:
835:
831:
821:
809:. Retrieved
789:
785:
775:
764:. Retrieved
753:. Springer.
749:
742:
707:
701:
661:
655:
649:
627:(6): 511–5.
624:
620:
614:
595:
585:
566:
552:
533:
529:
519:
507:. Retrieved
502:
461:
455:
430:
421:
417:
413:
410:Epidemiology
389:
380:
368:
362:
352:
349:
320:
304:
296:
248:
244:
232:
229:Psychosocial
206:
194:
178:
149:
148:
1908:Prostatitis
1840:Hypospermia
1830:Azoospermia
1705:MedlinePlus
1176:December 7,
505:. July 2014
311:hyperechoic
158:soft tissue
137:Named after
131:~10% of men
41:Other names
2133:Categories
2083:Varicocele
1890:Hematocele
1872:Epididymis
1787:Testicular
1670:DiseasesDB
1210:2020-01-17
1150:6 December
811:21 January
766:2020-01-17
509:25 October
447:References
1716:eMedicine
1681:SNOMED CT
1524:Br J Urol
1431:1743-6095
1269:254674530
1219:cite book
943:1678-7099
396:urologist
371:tadalafil
354:Vitamin E
341:Treatment
316:isoechoic
281:Diagnosis
128:Frequency
109:Specialty
2018:Priapism
2008:Phimosis
1971:External
1900:Prostate
1820:Aspermia
1795:Orchitis
1779:Internal
1772:genitals
1721:derm/851
1520:Kirby RS
1505:15116064
1439:21981606
1392:14551588
1351:23372611
1261:36513814
1126:10578409
1118:17352513
1083:12454684
1042:16698449
1007:14551587
961:30202130
864:19649505
806:22658761
734:38211880
726:14690485
678:23153101
561:(2010).
219:fibrosis
204:(CITA).
2070:Scrotum
1766:of the
1686:1335005
1664:D010411
1544:8944520
1342:3547530
969:license
952:6124582
899:8319059
855:5823162
641:9636000
427:History
386:Surgery
267:smoking
198:lesions
160:of the
123:Unknown
114:Urology
1768:pelvis
1710:001278
1653:171000
1642:607.85
1542:
1503:
1437:
1429:
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241:Causes
120:Causes
100:
2101:Other
1979:Penis
1675:29308
1627:N48.6
1265:S2CID
1122:S2CID
1098:Drugs
967:CC-BY
730:S2CID
162:penis
152:is a
1770:and
1659:MeSH
1648:OMIM
1637:9-CM
1540:PMID
1501:PMID
1435:PMID
1427:ISSN
1388:PMID
1347:PMID
1257:PMID
1225:link
1199:ISBN
1178:2013
1152:2013
1114:PMID
1079:PMID
1038:PMID
1003:PMID
957:PMID
939:ISSN
895:PMID
860:PMID
813:2020
802:PMID
755:ISBN
722:PMID
674:PMID
637:PMID
600:ISBN
571:ISBN
511:2017
466:ISBN
435:and
1633:ICD
1618:ICD
1578:at
1532:doi
1493:doi
1466:doi
1462:171
1419:doi
1378:doi
1337:PMC
1329:doi
1296:doi
1292:201
1249:doi
1106:doi
1069:doi
1030:doi
993:doi
947:PMC
931:doi
887:doi
850:PMC
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538:doi
398:at
305:On
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