271:(along with caffeine). It is prescribed in severe cases of asthma or those that are difficult to control. It must be taken 1–4 times daily, and doses cannot be missed. Blood tests are required to monitor therapy and to indicate when dosage adjustment is necessary. Side effects can include nausea, vomiting, diarrhea, stomach or headache, rapid or irregular heart beat, muscle cramps, nervous or jittery feelings, and hyperactivity. These symptoms may signal the need for an adjustment in medication. It may promote
1885:
1906:
248:-adrenergic agonist. While it is considered a relief or rescue medication, it can take a full hour to begin working. For this reason, it plays a secondary role in acute asthma treatment. Dry throat is the most common side effect. If the medication gets in contact with the eyes, it may cause blurred vision for a brief time.
243:
Only available as an inhalant, ipratropium bromide is used in the treatment of asthma and COPD. As a short-acting anticholinergic, it improves lung function and reduces the risk of exacerbation in people with symptomatic asthma. However, it will not stop an asthma attack already in progress. Because
157:
These are quick-relief or "rescue" medications that provide quick, temporary relief from asthma symptoms or flare-ups. These medications usually take effect within 20 minutes or less, and can last from four to six hours. These inhaled medications are best for treating sudden and severe or new asthma
200:
These are long-term medications taken routinely in order to control and prevent bronchoconstriction. They are not intended for fast relief. These medications may take longer to begin working, but relieve airway constriction for up to 12 hours. Commonly taken twice a day with an anti-inflammatory
279:, can interfere with the way theophylline works. Coffee, tea, colas, cigarette-smoking, and viral illnesses can all affect the action of theophylline and change its effectiveness. A physician should monitor dosage levels to meet each patient's profile and needs.
820:"A phase I, placebo-controlled, randomized, double-blind, single ascending dose-ranging study to evaluate the safety and tolerability of a novel biophysical bronchodilator (S-1226) administered by nebulization in healthy volunteers"
817:
Green, Francis H. Y.; Leigh, Richard; Fadayomi, Morenike; Lalli, Gurkeet; Chiu, Andrea; Shrestha, Grishma; ElShahat, Sharif G.; Nelson, David Evan; El Mays, Tamer Y.; Pieron, Cora A.; Dennis, John H. (2016-07-28).
345:
The bronchodilators are divided into short- and long-acting groups. Short-acting bronchodilators are used for relief of bronchoconstriction, while long-acting bronchodilators are predominantly used for prevention.
325:
induced by carbon dioxide inhalation reduces it; however, this bronchodilating effect of carbon dioxide inhalation only lasts 4 to 5 minutes. Nonetheless, this observation has inspired the development of
1943:
158:
symptoms. Taken 15 to 20 minutes ahead of time, these medications can also prevent asthma symptoms triggered by exercise or exposure to cold air. Some short-acting β-agonists, such as
1837:
917:
803:
2580:
1936:
2715:
2565:
1894:
1929:
618:
Griffiths B, Ducharme FM (December 2013). "Combined inhaled anticholinergics and short-acting beta2-agonists for initial treatment of acute asthma in children".
2605:
2575:
275:, also known as GERD, by relaxing the lower esophageal sphincter muscle. Some medications, such as seizure and ulcer medications and antibiotics containing
907:
1688:
3081:
885:
182:-adrenergic agonist should consult their doctor, as such usage indicates uncontrolled asthma, and their routine medications may need adjustment.
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2444:
2109:
2063:
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237:
195:
111:
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1548:
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2600:
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452:
3195:
2701:
2645:
2462:
1444:
900:
306:-adrenergic agonists for use as bronchodilator, but are now rarely, if ever, used medically for their bronchodilatory effects.
272:
3071:
652:
133:. Long-acting bronchodilators help to control and prevent symptoms. The three types of prescription bronchodilating drugs are
2615:
2585:
129:
Bronchodilators are either short-acting or long-acting. Short-acting medications provide quick or "rescue" relief from acute
2798:
2555:
255:-adrenergic agonists has been shown to reduce hospital admissions in children and adults with acute asthma exacerbations.
1143:
3200:
2920:
925:
3090:
3039:
2890:
2676:
1754:
571:"Anticholinergics in the treatment of children and adults with acute asthma: a systematic review with meta-analysis"
3044:
2227:
1953:
1404:
893:
758:"Site of action of inhaled 6 per cent carbon dioxide in the lungs of asthmatic subjects before and after exercise"
2952:
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2864:
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1987:
134:
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are the most common conditions. Although this remains somewhat controversial, they might be useful in
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377:
130:
1905:
701:"Effects of hypercapnia and hypocapnia on respiratory resistance in normal and asthmatic subjects"
470:"Pharmacologic Agents That Promote Airway Clearance in Hospitalized Subjects: A Systematic Review"
244:
it has no effect on asthma symptoms when used alone, it is most often paired with a short-acting β
3131:
3126:
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2300:
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502:
83:
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267:
is a long-acting bronchodilator that prevents asthma episodes. It belongs to the chemical class
236:
Tiotropium is a long-acting, 24-hour, anticholinergic bronchodilator used in the management of
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medication, they maintain open airways and prevent asthma symptoms, particularly at night.
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522:"Is there a rationale and role for long-acting anticholinergic bronchodilators in asthma?"
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administered for the treatment of breathing difficulties, usually in the form of
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773:
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van den
Elshout, F. J.; van Herwaarden, C. L.; Folgering, H. T. (January 1991).
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43:
631:
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2019:
2014:
2004:
1999:
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208:
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159:
95:
91:
79:
845:
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724:
520:
Price D, Fromer L, Kaplan A, van der Molen T, Román-RodrĂguez M (July 2014).
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2009:
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1729:
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331:
171:
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498:
489:
468:
Sathe NA, Krishnaswami S, Andrews J, Ficzere C, McPheeters ML (July 2015).
742:
2693:
2452:
2343:
1978:
1850:
1714:
1710:
1683:
1122:
1055:
974:
789:
75:
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1409:
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998:
948:
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167:
99:
52:
2738:
2640:
2165:
1957:
1508:
1171:
327:
299:
178:). Patients who regularly or frequently need to take a short-acting β
107:
166:-adrenergic agonists and can relieve bronchospasms without unwanted
2635:
2169:
1808:
1518:
1013:
71:
3135:
2834:
1512:
87:
2697:
1925:
889:
251:
The use of anticholinergics in combination with short-acting β
286:
drugs that have an amphetamine like mode of action, such as
122:. They are often prescribed but of unproven significance in
655:
is listed as having medical uses as bronchodilator. Medic8
298:, have bronchodilating effects and were used often for
918:
170:
side effects of nonspecific β-agonists (for example,
74:
inhibition as well) is a substance that dilates the
3145:
3021:
2995:
2906:
2824:
2731:
2581:
Fluticasone furoate/umeclidinium bromide/vilanterol
2548:
2512:
2484:
2461:
2443:
2415:
2405:
2342:
2319:
2271:
2218:
2150:
2108:
2062:
1986:
1973:
1835:
1807:
1763:
1572:
1507:
1470:
1418:
1331:
1275:
1235:
1192:
1076:
1012:
924:
37:
32:
569:Rodrigo GJ, Castro-Rodriguez JA (September 2005).
802:: CS1 maint: DOI inactive as of September 2024 (
2566:Beclometasone/formoterol/glycopyrronium bromide
756:Fisher, H. K.; Hansen, T. A. (November 1976).
330:, carbon dioxide-enriched air formulated with
162:, are specific to the lungs; they are called β
2709:
2606:Indacaterol/glycopyrronium bromide/mometasone
1937:
901:
8:
2576:Budesonide/glycopyrronium bromide/formoterol
916:Major chemical drug groups – based upon the
70:(although the latter occasionally includes
2716:
2702:
2694:
2412:
1983:
1944:
1930:
1922:
908:
894:
886:
762:The American Review of Respiratory Disease
380:(Asthmanefrin, Primatene Mist Replacement)
853:
835:
732:
594:
545:
488:
433:
321:increases respiratory resistance while
263:Available in oral and injectable form,
2445:Arachidonate 5-lipoxygenase inhibitors
1895:Pharmacological classification systems
1262:Selective estrogen receptor modulators
795:
349:Short-acting bronchodilators include:
225:Some examples of anticholinergics are
29:
1542:Non-steroidal anti-inflammatory drugs
526:npj Primary Care Respiratory Medicine
444:Taber's Cyclopedic Medical Dictionary
395:Long-acting bronchodilators include:
238:chronic obstructive pulmonary disease
196:Long-acting beta-adrenoceptor agonist
112:chronic obstructive pulmonary disease
92:originating naturally within the body
7:
3082:oxygen–hemoglobin dissociation curve
2641:Theophylline/ephedrine/phenobarbital
1155:Angiotensin II receptor antagonists
48:
3008:hypoxic pulmonary vasoconstriction
2636:Theophylline/ephedrine/hydroxyzine
2601:Indacaterol/glycopyrronium bromide
668:Cocaine: An Unauthorized Biography
356:/albuterol (Proventil or Ventolin)
27:Drug which widens the lung airways
25:
2626:Salbutamol (albuterol)/budesonide
2596:Glycopyrronium bromide/formoterol
2591:Fluticasone propionate/salmeterol
313:also relaxes airway musculature:
2463:Thromboxane receptor antagonists
1904:
1884:
1883:
2646:Umeclidinium bromide/vilanterol
1292:Hypothalamic–pituitary hormones
82:, decreasing resistance in the
2616:Ipratropium bromide/salbutamol
2586:Fluticasone furoate/vilanterol
2201:Orciprenaline (metaproterenol)
665:Streatfeild D (17 June 2003).
620:Paediatric Respiratory Reviews
302:due to the lack of effective β
141:(short- and long-acting), and
86:and increasing airflow to the
1:
2556:Aclidinium bromide/formoterol
2044:Levosalbutamol (levalbuterol)
1044:Thrombolytics / fibrinolytics
2191:Isoprenaline (isoproterenol)
1755:Wakefulness-promoting agents
441:Venes, Donald (2017-01-25).
3040:Ventilation/perfusion ratio
2891:pulmonary stretch receptors
2166:+theophylline/phenobarbital
1954:obstructive airway diseases
774:10.1164/arrd.1976.114.5.861
3222:
3206:Pulmonary function testing
3072:alveolar–arterial gradient
1405:Intravenous immunoglobulin
671:. Macmillan. p. 110.
632:10.1016/j.prrv.2013.08.002
218:
193:
137:(short- and long-acting),
135:beta-2 adrenergic agonists
102:. They are most useful in
2953:respiratory minute volume
2865:ventral respiratory group
2654:
1879:
837:10.1186/s13063-016-1489-8
124:restrictive lung diseases
104:obstructive lung diseases
90:. Bronchodilators may be
49:
2860:dorsal respiratory group
2754:obligate nasal breathing
2561:Beclometasone/formoterol
2170:theophylline/hydroxyzine
2110:Ultra-long-acting β
1460:Topoisomerase inhibitors
1144:renin–angiotensin system
1138:Calcium channel blockers
3062:pulmonary gas pressures
2417:Leukotriene antagonists
776:(inactive 2024-09-12).
587:10.1136/thx.2005.040444
538:10.1038/npjpcrm.2014.23
362:/levalbuterol (Xopenex)
211:are examples of these.
3196:Respiratory physiology
2816:mechanical ventilation
2725:Respiratory physiology
2631:Theophylline/ephedrine
2611:Indacaterol/mometasone
2372:Choline theophyllinate
2291:Glycopyrronium bromide
2253:Fluticasone propionate
2040:Salbutamol (albuterol)
1252:Hormonal contraception
1182:Bile acid sequestrants
963:Proton-pump inhibitors
926:gastrointestinal tract
490:10.4187/respcare.04086
402:(Serevent or Seretide)
341:Common bronchodilators
18:Inhaled bronchodilator
3067:alveolar gas equation
3003:pulmonary circulation
2621:Mometasone/formoterol
2571:Budesonide/formoterol
2321:Mast cell stabilizers
2278:muscarinic antagonist
317:caused by deliberate
3122:respiratory quotient
2977:body plethysmography
2896:Hering–Breuer reflex
2771:pulmonary surfactant
2549:Combination products
2311:Umeclidinium bromide
1861:Radiopharmaceuticals
1649:Antiparkinson agents
190:-adrenergic agonists
153:-adrenergic agonists
3201:Respiratory therapy
2965:Lung function tests
2799:hyperresponsiveness
2296:Ipratropium bromide
1988:Short-acting β
1644:Antimigraine agents
1634:Antidementia agents
1537:Anti-inflammatories
1227:Medicated dressings
1167:Antihyperlipidemics
994:Diabetes medication
717:10.1136/thx.46.1.28
378:Racemic Epinephrine
282:Additionally, some
231:ipratropium bromide
131:bronchoconstriction
3132:diffusion capacity
3127:arterial blood gas
3107:carbonic anhydrase
2841:pneumotaxic center
2681:Never to phase III
2306:Tiotropium bromide
2301:Oxitropium bromide
2286:Aclidinium bromide
2064:Long-acting β
1497:Immunosuppressants
1367:Antimycobacterials
1323:Antithyroid agents
1307:Mineralocorticoids
1111:Cardiac stimulants
1101:Cardiac glycosides
1093:cardiac therapy /
989:Anti-obesity drugs
84:respiratory airway
3178:
3177:
3086:Oxygen saturation
3052:zones of the lung
2791:airway resistance
2691:
2690:
2508:
2507:
2214:
2213:
1919:
1918:
1822:Ophthalmologicals
1532:Anabolic steroids
1435:Anticancer agents
1398:Ectoparasiticides
1118:Antihypertensives
1066:Antifibrinolytics
678:978-0-312-42226-4
94:, or they may be
60:
59:
16:(Redirected from
3213:
2987:nitrogen washout
2846:apneustic center
2761:respiratory rate
2718:
2711:
2704:
2695:
2413:
2273:Anticholinergics
1984:
1946:
1939:
1932:
1923:
1908:
1887:
1886:
1871:Senotherapeutics
1725:Neuroprotectives
1720:Mood stabilizers
1619:Anti-ADHD agents
1559:Muscle relaxants
1492:Immunostimulants
1487:Immunomodulators
1319:Thyroid hormones
1257:Fertility agents
1160:Renin inhibitors
1051:Antihemorrhagics
1018:forming organs (
1004:Dietary minerals
910:
903:
896:
887:
881:Drug information
868:
867:
857:
839:
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808:
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549:
517:
511:
510:
492:
477:Respiratory Care
474:
465:
459:
458:
438:
374:(Primatene Mist)
319:hyperventilation
221:Anticholinergics
215:Anticholinergics
139:anticholinergics
53:edit on Wikidata
30:
21:
3221:
3220:
3216:
3215:
3214:
3212:
3211:
3210:
3191:Bronchodilators
3181:
3180:
3179:
3174:
3165:oxygen toxicity
3141:
3029:ventilation (V)
3017:
3013:pulmonary shunt
2991:
2982:peak flow meter
2902:
2820:
2727:
2722:
2692:
2687:
2686:
2671:Clinical trials
2650:
2544:
2504:
2487:PDE4 inhibitors
2480:
2457:
2439:
2401:
2338:
2315:
2276:
2267:
2220:Glucocorticoids
2210:
2196:Methylephedrine
2146:
2113:
2104:
2067:
2058:
1991:
1969:
1950:
1920:
1915:
1911:Medicine portal
1875:
1831:
1803:
1798:
1790:Cough medicines
1785:Bronchodilators
1766:
1759:
1639:Antidepressants
1629:Anticonvulsants
1577:
1568:
1564:Bisphosphonates
1554:Corticosteroids
1516:
1503:
1475:
1466:
1450:Spindle poisons
1440:Antimetabolites
1423:
1414:
1336:
1327:
1302:Glucocorticoids
1297:Corticosteroids
1278:
1271:
1238:
1231:
1188:
1106:Antiarrhythmics
1079:
1072:
1029:Antithrombotics
1017:
1008:
984:Antipropulsives
980:Antidiarrhoeals
957:
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292:methamphetamine
284:psychostimulant
269:methylxanthines
261:
254:
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217:
198:
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189:
181:
165:
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145:(long-acting).
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28:
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15:
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5:
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3111:chloride shift
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3101:Haldane effect
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3054:
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2990:
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2979:
2974:
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2961:
2960:
2958:FEV1/FVC ratio
2955:
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2948:
2944:
2943:
2938:
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2928:
2923:
2918:
2912:
2910:
2904:
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2888:
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2886:
2881:
2873:chemoreceptors
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2822:
2821:
2819:
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2813:
2812:
2811:
2806:
2801:
2793:
2788:
2783:
2781:elastic recoil
2778:
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2763:
2758:
2757:
2756:
2751:
2746:
2735:
2733:
2729:
2728:
2723:
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2706:
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2513:Others/unknown
2510:
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2497:
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2255:
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2209:
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2097:
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2083:
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2065:
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2037:
2032:
2027:
2022:
2017:
2012:
2007:
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1996:
1994:
1989:
1981:
1971:
1970:
1951:
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1926:
1917:
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1856:Contrast media
1853:
1847:
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1833:
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1824:
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1816:
1809:sensory organs
1805:
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1654:Antipsychotics
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1624:Antiaddictives
1621:
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1604:
1594:
1588:
1586:
1579:nervous system
1570:
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1556:
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1549:Antirheumatics
1546:
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1500:
1499:
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1462:
1457:
1455:Antineoplastic
1452:
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1429:
1416:
1415:
1413:
1412:
1407:
1402:
1401:
1400:
1395:
1390:
1388:Antiprotozoals
1383:Antiparasitics
1380:
1375:
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1363:Antibacterials
1359:Antimicrobials
1355:
1353:
1329:
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1190:
1189:
1187:
1186:
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1184:
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1162:
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1152:
1150:ACE inhibitors
1140:
1135:
1130:
1125:
1120:
1115:
1114:
1113:
1108:
1103:
1089:
1087:
1078:cardiovascular
1074:
1073:
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1063:
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1048:
1047:
1046:
1041:
1039:Anticoagulants
1036:
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1010:
1009:
1007:
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875:External links
873:
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768:(5): 861–870.
748:
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483:(7): 1061–70.
460:
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447:. F.A. Davis.
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149:Short-acting β
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120:bronchiectasis
64:bronchodilator
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33:Bronchodilator
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2786:hysteresivity
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2385:
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2239:
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2233:Betamethasone
2231:
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2228:Beclometasone
2226:
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2223:
2221:
2217:
2207:
2204:
2202:
2199:
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2189:
2187:
2186:Hexoprenaline
2184:
2182:
2179:
2177:
2174:
2171:
2167:
2163:
2162:+theophylline
2159:
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1393:Anthelmintics
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1247:
1244:
1240:
1237:genitourinary
1234:
1228:
1225:
1223:
1220:
1218:
1217:Antipruritics
1215:
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1133:Beta blockers
1131:
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1054:
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1042:
1040:
1037:
1035:
1034:Antiplatelets
1032:
1031:
1030:
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1026:
1024:
1021:
1015:
1011:
1005:
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1000:
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531:
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454:9780803659407
450:
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186:Long-acting β
185:
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177:
173:
169:
161:
148:
146:
144:
140:
136:
132:
127:
125:
121:
117:
116:bronchiolitis
113:
109:
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101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
54:
45:
42:
40:
36:
31:
19:
3057:gas exchange
3022:Interactions
2947:calculations
2908:Lung volumes
2871:
2852:
2833:
2804:constriction
2766:respirometer
2525:Ensifentrine
2397:Theophylline
2382:Enprofylline
2357:Ambuphylline
2329:Cromoglicate
2206:Racephedrine
2090:Arformoterol
1784:
1694:Psychedelics
1664:Aphrodisiacs
1338:infestations
1314:Sex hormones
1267:Sex hormones
1212:Cicatrizants
1142:
1128:Vasodilators
1095:antianginals
1092:
944:stomach acid
943:
827:
823:
812:
798:cite journal
765:
761:
751:
711:(1): 28–32.
708:
704:
694:
682:. Retrieved
667:
660:
648:
626:(4): 234–5.
623:
619:
613:
581:(9): 740–6.
578:
574:
564:
532:(1): 14023.
529:
525:
515:
480:
476:
463:
443:
436:
394:
348:
344:
308:
281:
277:erythromycin
265:theophylline
262:
250:
242:
235:
224:
203:
199:
156:
143:theophylline
128:
68:broncholytic
67:
63:
61:
3096:Bohr effect
2996:Circulation
2732:Respiration
2667:from market
2500:Roflumilast
2476:Seratrodast
2435:Zafirlukast
2425:Montelukast
2377:Doxofylline
2367:Bamifylline
2248:Flunisolide
2243:Ciclesonide
2176:Epinephrine
2132:Indacaterol
2081:Clenbuterol
2054:Tulobuterol
2049:Terbutaline
1975:Adrenergics
1827:Otologicals
1799:antagonists
1765:respiratory
1740:Orexigenics
1735:Neurotoxins
1684:Euphoriants
1674:Entactogens
1669:Depressants
1659:Anxiolytics
1597:Anesthetics
1373:Antifungals
970:Antiemetics
958:antagonists
684:14 February
653:Amphetamine
422:Indacaterol
408:(Spiropent)
406:Clenbuterol
390:Terbutaline
372:Epinephrine
323:hypercapnia
288:amphetamine
273:acid reflux
176:epinephrine
106:, of which
96:medications
80:bronchioles
44:Pulmonology
3185:Categories
3158:death zone
3077:hemoglobin
2972:spirometry
2931:dead space
2884:peripheral
2809:dilatation
2795:bronchial
2776:compliance
2749:exhalation
2744:inhalation
2540:Omalizumab
2535:Fenspiride
2471:Ramatroban
2430:Pranlukast
2409:inhibition
2407:Eicosanoid
2352:Acefylline
2334:Nedocromil
2258:Mometasone
2238:Budesonide
2181:Etafedrine
2142:Vilanterol
2137:Olodaterol
2127:Carmoterol
2122:Abediterol
2100:Salmefamol
2095:Salmeterol
2086:Formoterol
2076:Bambuterol
2030:Reproterol
2025:Procaterol
2020:Pirbuterol
2015:Isoetarine
2005:Carbuterol
2000:Bitolterol
1952:Drugs for
1750:Stimulants
1730:Nootropics
1704:Deliriants
1679:Entheogens
1614:Anorectics
1592:Analgesics
1445:Alkylating
1378:Antivirals
1333:infections
1207:Emollients
1061:Coagulants
931:metabolism
428:References
417:Bambuterol
412:Formoterol
400:Salmeterol
386:(Bronkaid)
366:Pirbuterol
354:Salbutamol
335:perflubron
315:hypocapnia
227:tiotropium
209:formoterol
205:Salmeterol
160:salbutamol
3034:Perfusion
2677:Phase III
2665:Withdrawn
2530:Eprozinol
2520:Amlexanox
2495:Ibudilast
2344:Xanthines
2158:Ephedrine
2035:Rimiterol
2010:Fenoterol
1979:inhalants
1900:ATC codes
1866:Dressings
1851:Antidotes
1715:Sedatives
1711:Hypnotics
1420:malignant
1277:endocrine
1123:Diuretics
1056:Platelets
1016:and blood
975:Laxatives
846:1745-6215
782:0003-0805
725:0040-6376
384:Ephedrine
332:nebulized
172:ephedrine
72:secretory
39:Specialty
3045:V/Q scan
2453:Zileuton
2114:agonists
2068:agonists
1992:agonists
1745:Serenics
1410:Vaccines
1177:Fibrates
999:Vitamins
949:Antacids
864:27464582
640:24070913
605:16055613
556:25030457
499:25944943
368:(Maxair)
309:Gaseous
240:(COPD).
100:inhalers
3170:hypoxia
3091:2,3-BPG
2879:central
2854:medulla
2826:Control
1602:General
1509:muscles
1478:L03–L04
1474:disease
1426:L01–L02
1422:disease
1172:Statins
855:4964056
830:: 361.
743:1908137
734:1020910
596:1747524
547:4373380
507:7017557
296:cocaine
168:cardiac
76:bronchi
2739:breath
2660:WHO-EM
1958:asthma
1909:
1888:
1836:other
1767:system
1519:joints
1472:immune
1279:system
1239:system
1080:system
862:
852:
844:
824:Trials
790:984580
788:
780:
741:
731:
723:
705:Thorax
675:
638:
603:
593:
575:Thorax
554:
544:
505:
497:
451:
328:S-1226
300:asthma
294:, and
108:asthma
2151:Other
1890:Drugs
1607:Local
1574:brain
1513:bones
1014:blood
503:S2CID
473:(PDF)
259:Other
88:lungs
51:[
3136:DLCO
3036:(Q)
2835:pons
1962:COPD
1517:and
1194:skin
860:PMID
842:ISSN
804:link
786:PMID
778:ISSN
739:PMID
721:ISSN
686:2011
673:ISBN
636:PMID
601:PMID
552:PMID
495:PMID
449:ISBN
207:and
118:and
110:and
78:and
2941:PEF
2921:FRC
1966:R03
1838:ATC
1576:and
1335:and
850:PMC
832:doi
770:doi
766:114
729:PMC
713:doi
628:doi
591:PMC
583:doi
542:PMC
534:doi
485:doi
174:or
66:or
3187::
2936:CC
2926:Vt
2916:VC
2673::
2168:,
2164:,
1977:,
1956::
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1511:,
1361::
1350:QI
1348:,
1344:,
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796:{{
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2710:t
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2275:/
2172:)
2160:(
2112:2
2088:/
2066:2
2042:/
1990:2
1968:)
1964:(
1960:/
1945:e
1938:t
1931:v
1844:)
1842:V
1840:(
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1813:S
1811:(
1797:1
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1773:)
1771:R
1769:(
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1521:(
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1424:(
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1365:(
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1346:P
1342:J
1340:(
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1281:(
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1243:G
1241:(
1200:)
1198:D
1196:(
1086:)
1084:C
1082:(
1022:)
1020:B
956:2
954:H
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866:.
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806:)
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745:.
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630::
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304:2
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246:2
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