50:
2465:
Mostoslavsky, R; Chua, KF; Lombard, DB; Pang, WW; Fischer, MR; Gellon, L; Liu, P; Mostoslavsky, G; Franco, S; Murphy, MM; Mills, KD; Patel, P; Hsu, JT; Hong, AL; Ford, E; Cheng, HL; Kennedy, C; Nunez, N; Bronson, R; Frendewey, D; Auerbach, W; Valenzuela, D; Karow, M; Hottiger, MO; Hursting, S;
1513:
Vermeij WP, Dollé ME, Reiling E, Jaarsma D, Payan-Gomez C, Bombardieri CR, Wu H, Roks AJ, Botter SM, van der Eerden BC, Youssef SA, Kuiper RV, Nagarajah B, van
Oostrom CT, Brandt RM, Barnhoorn S, Imholz S, Pennings JL, de Bruin A, Gyenis Ă, Pothof J, Vijg J, van Steeg H, Hoeijmakers JH (2016).
639:âit is too lethal to display symptoms (much less symptoms of cancer or "accelerated aging"). Rothmund-Thomson syndrome and xeroderma pigmentosum display symptoms dominated by vulnerability to cancer, whereas progeria and Werner syndrome show the most features of "accelerated aging".
691:
are identifiable symptoms associated with mechanisms of molecular damage. The fact that these phenotypes are widely recognized justifies classification of the relevant diseases as "accelerated aging". Such conditions, it is argued, are readily distinguishable from
2952:
Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadiñanos J, LĂłpez-OtĂn C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z (2005). "Genomic instability in laminopathy-based premature aging".
736:
is present in a DNA repair gene, the repair gene will either not be expressed or be expressed in an altered form. Then the repair function will likely be deficient, and, as a consequence, damages will tend to accumulate. Such DNA damages can cause errors during
288:
in which patients have segmental progeria with reduced stature, intellectual disability, cachexia (loss of subcutaneous fat tissue), sensorineural deafness, retinal degeneration, and calcification of the central nervous system; other mutations in ERCC2 cause
329:
mutations in ERCC4 cause symptoms of accelerated aging that affect the neurologic, hepatobiliary, musculoskeletal, and hematopoietic systems, and cause an old, wizened appearance, loss of subcutaneous fat, liver dysfunction, vision and hearing loss,
4781:
651:, but displays no symptoms of "accelerated aging". On the other hand, Cockayne Syndrome and trichothiodystrophy show mainly features of accelerated aging, but apparently without an increased risk of cancer Some DNA repair defects manifest as
5511:
667:
Some biogerontologists question that such a thing as "accelerated aging" actually exists, at least partly on the grounds that all of the so-called accelerated aging diseases are segmental progerias. Many disease conditions such as
615:
lack of Zmpste24 prevents lamin A formation and causes progeroid phenotypes in mice and humans, increased DNA damage and chromosome aberrations, sensitivity to DNA-damaging agents and deficiency in homologous recombination
220:
deletion of ATR in adult mice leads to a number of disorders including hair loss and graying, kyphosis, osteoporosis, premature involution of the thymus, fibrosis of the heart and kidney and decreased spermatogenesis
5586:
4774:
3364:
Bernstein C, Bernstein H, Payne CM, Garewal H. DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis. Mutat Res. 2002 Jun;511(2):145-78.
4767:
1571:
Dollé ME, Kuiper RV, Roodbergen M, Robinson J, de Vlugt S, Wijnhoven SW, Beems RB, de la
Fonteyne L, de With P, van der Pluijm I, Niedernhofer LJ, Hasty P, Vijg J, Hoeijmakers JH, van Steeg H (2011).
576:
mice defective in SIRT7 show phenotypic and molecular signs of accelerated aging such as premature pronounced curvature of the spine, reduced life span, and reduced non-homologous end joining
3931:
Anbari KK, Ierardi-Curto LA, Silber JS, Asada N, Spinner N, Zackai EH, Belasco J, Morrissette JD, Dormans JP (2000). "Two primary osteosarcomas in a patient with
Rothmund-Thomson syndrome".
358:
mice with deficient ERCC5 show loss of subcutaneous fat, kyphosis, osteoporosis, retinal photoreceptor loss, liver aging, extensive neurodegeneration, and a short lifespan of 4â5 months
5864:
5734:
3464:"Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways"
5602:
5006:
5035:
5001:
1718:
Trego KS, Groesser T, Davalos AR, Parplys AC, Zhao W, Nelson MR, Hlaing A, Shih B, Rydberg B, Pluth JM, Tsai MS, Hoeijmakers JH, Sung P, Wiese C, Campisi J, Cooper PK (2016).
293:
in which patients have segmental progeria with brittle hair, short stature, progressive cognitive impairment and abnormal face shape; still other mutations in ERCC2 cause
3424:
Lancaster JM, Powell CB, Chen LM, Richardson DL (2015). "Society of
Gynecologic Oncology statement on risk assessment for inherited gynecologic cancer predispositions".
4942:
1979:
Theil AF, Nonnekens J, Steurer B, Mari PO, de Wit J, Lemaitre C, Marteijn JA, Raams A, Maas A, Vermeij M, Essers J, Hoeijmakers JH, Giglia-Mari G, Vermeulen W (2013).
704:. It is further argued that segmental aging phenotype is a natural part of aging insofar as genetic variation leads to some people being more disposed than others to
561:
SIRT6-deficient mice develop profound lymphopenia, loss of subcutaneous fat and lordokyphosis, and these defects overlap with aging-associated degenerative processes
5442:
3645:
Bartkova J, Tommiska J, Oplustilova L, Aaltonen K, Tamminen A, Heikkinen T, Mistrik M, AittomÀki K, Blomqvist C, HeikkilÀ P, Lukas J, Nevanlinna H, Bartek J (2008).
4937:
5438:
5744:
3606:"After double-strand break induction by UV-A, homologous recombination and nonhomologous end joining cooperate at the same DSB if both systems are available"
1622:"XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase"
5389:
5250:
5030:
5025:
5015:
1816:
Weinfeld M, Xing JZ, Lee J, Leadon SA, Cooper PK, Le XC (2001). "Factors influencing the removal of thymine glycol from DNA in Îł-irradiated human cells".
503:
mutation in NRMT1 causes decreased body size, female-specific infertility, kyphosis, decreased mitochondrial function, and early-onset liver degeneration
5769:
5506:
5054:
741:
leading to mutations, some of which may give rise to cancer. Germ-line DNA repair mutations that increase the risk of cancer are listed in the Table.
1408:
Peddi P, Loftin CW, Dickey JS, Hair JM, Burns KJ, Aziz K, Francisco DC, Panayiotidis MI, Sedelnikova OA, Bonner WM, Winters TA, Georgakilas AG (2010).
5729:
5324:
5049:
4981:
640:
263:
mice are leukopenic and thrombocytopenic, and there is extensive adipose transformation of the bone marrow, hallmark features of normal aging in mice
5794:
5384:
5379:
5020:
4986:
1349:
Reiling E, Dollé ME, Youssef SA, Lee M, Nagarajah B, Roodbergen M, de With P, de Bruin A, Hoeijmakers JH, Vijg J, van Steeg H, Hasty P (2014).
891:
210:
3647:"Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene"
2229:
Gonzalo S, Kreienkamp R (2016). "Methods to
Monitor DNA Repair Defects and Genomic Instability in the Context of a Disrupted Nuclear Lamina".
627:
Most of the DNA repair deficiency diseases show varying degrees of "accelerated aging" or cancer (often some of both). But elimination of any
4996:
4855:
2246:
4233:
Opletalova K, Bourillon A, Yang W, Pouvelle C, Armier J, Despras E, Ludovic M, Mateus C, Robert C, Kannouche P, Soufir N, Sarasin A (2014).
2515:
Vazquez BN, Thackray JK, Simonet NG, Kane-Goldsmith N, Martinez-Redondo P, Nguyen T, Bunting S, Vaquero A, Tischfield JA, Serrano L (2016).
5516:
5101:
2721:
Das A, Boldogh I, Lee JW, Harrigan JA, Hegde ML, Piotrowski J, de Souza Pinto N, Ramos W, Greenberg MM, Hazra TK, Mitra S, Bohr VA (2007).
4235:"Correlation of phenotype/genotype in a cohort of 23 xeroderma pigmentosum-variant patients reveals 12 new disease-causing POLH mutations"
1202:"Transcriptional and Posttranslational Regulation of Nucleotide Excision Repair: The Guardian of the Genome against Ultraviolet Radiation"
4991:
1936:
D'Errico M, Pascucci B, Iorio E, Van Houten B, Dogliotti E (2013). "The role of CSA and CSB protein in the oxidative stress response".
5809:
5754:
4739:
1769:"Nucleotide excision repair 3' endonuclease XPG stimulates the activity of base excision repair enzyme thymine glycol DNA glycosylase"
324:
3000:
5281:
5111:
5044:
4679:
1833:
17:
5298:
3976:"Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights"
5394:
4749:
3065:
Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J (February 2003). "Aging and genome maintenance: lessons from the mouse?".
5799:
4888:
4754:
5819:
5749:
5719:
5596:
5369:
5074:
4947:
4932:
5121:
5433:
5344:
4744:
156:
2762:
Kanagaraj R, Parasuraman P, Mihaljevic B, van Loon B, Burdova K, König C, Furrer A, Bohr VA, HĂŒbscher U, Janscak P (2012).
5869:
5759:
5712:
5339:
5262:
4976:
4922:
805:
800:
4759:
4674:
1251:
Ruzankina Y, Pinzon-Guzman C, Asare A, Ong T, Pontano L, Cotsarelis G, Zediak VP, Velez M, Bhandoola A, Brown EJ (2007).
452:
shorter lifespan, earlier onset of aging related pathologies; persistent foci of DNA double-strand break repair proteins
259:
with time-dependent accumulation of transcription-blocking damages; mouse life span reduced from 2.5 years to 5 months;)
5167:
4859:
3208:
5784:
5501:
5161:
5245:
5152:
1253:"Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss"
1671:"Deficiency in the nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV irradiation"
886:
leukemia, lymphoma, colon, breast, skin, lung, auditory canal, tongue, esophagus, stomach, tonsil, larynx, uterus
5374:
1170:
1097:
994:
959:
843:
833:
823:
656:
590:
571:
556:
548:
525:
517:
498:
477:
462:
447:
425:
403:
397:
375:
369:
345:
312:
274:
256:
246:
231:
215:
5578:
5126:
406:
with accumulation of unrepaired DNA damages, also defective repair of oxidatively generated DNA damages including
378:
with accumulation of unrepaired DNA damages, also defective repair of oxidatively generated DNA damages including
5144:
4869:
705:
278:
93:
75:
5329:
5419:
5407:
5365:
5351:
5319:
5315:
5223:
5218:
5213:
5209:
5201:
5172:
4630:
2723:"The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1"
998:
819:
815:
789:
610:
586:
581:
552:
521:
481:
349:
320:
4131:"Nucleotide excision repair proteins rapidly accumulate but fail to persist in human XP-E (DDB2 mutant) cells"
5697:
5116:
5079:
4927:
2615:"DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells"
1410:"DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells"
5303:
5130:
5106:
4694:
5814:
5779:
5702:
5496:
5484:
5334:
5177:
4734:
4709:
4704:
4699:
4659:
4654:
3015:
713:
467:
shorter lifespan, earlier onset of aging related pathologies; defective repair of spontaneous DNA damage
331:
4729:
4689:
4669:
4649:
5679:
5590:
4966:
4815:
4724:
4719:
4714:
4684:
4664:
4429:
Viktorsson K, De Petris L, Lewensohn R (2005). "The role of p53 in treatment responses of lung cancer".
4390:"DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture"
2379:
Lu L, Jin W, Wang LL (2017). "Aging in
Rothmund-Thomson syndrome and related RECQL4 genetic disorders".
2282:"α-N-methylation of damaged DNA-binding protein 2 (DDB2) and its function in nucleotide excision repair"
986:
430:
deficiency causes trichothiodystrophy (TTD) a premature-ageing and neuroectodermal disease; humans with
294:
171:
130:
1115:
Direct role in HRR, BER, NER and acts in DNA damage response for those pathways and for NHEJ and MMR
534:
cause
Rothmund-Thomson syndrome, with alopecia, sparse eyebrows and lashes, cataracts and osteoporosis
1981:"Disruption of TTDA results in complete nucleotide excision repair deficiency and embryonic lethality"
5669:
5571:
5089:
3707:
2677:
1527:
1362:
1165:
1146:
1089:
1012:
900:
684:
it is hard to support the claim that a disease condition represents more than accelerated mortality.
632:
594:
544:
513:
353:
236:
shorter lifespan, earlier onset of aging related pathologies; higher level of DNA damage persistence
49:
5874:
5854:
5477:
5356:
4906:
4864:
4847:
4837:
4820:
4790:
3020:
2133:"DNA repair kinetics in SCID mice Sertoli cells and DNA-PKcs-deficient mouse embryonic fibroblasts"
1720:"Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability"
1067:
701:
681:
648:
316:
298:
290:
250:
191:
183:
161:
2032:"Slowly progressing nucleotide excision repair in trichothiodystrophy group A patient fibroblasts"
5739:
5255:
4952:
4898:
4878:
4829:
4264:
4054:
3956:
3493:
3347:
3298:
3249:
3189:
3090:
2978:
2934:
2909:
Veith S, Mangerich A (2015). "RecQ helicases and PARP1 team up in maintaining genome integrity".
2497:
2447:
2404:
1961:
1851:
1138:
2333:"NRMT1 knockout mice exhibit phenotypes associated with impaired DNA repair and premature aging"
2084:"Deletion of Ku80 causes early aging independent of chronic inflammation and Rag-1-induced DSBs"
5859:
5764:
5724:
5646:
5521:
5465:
5399:
5064:
4593:
4544:
4495:
4446:
4411:
4370:
4316:
4256:
4212:
4160:
4108:
4046:
4005:
3948:
3913:
3864:
3815:
3776:
3735:
3676:
3627:
3586:
3532:
3485:
3441:
3406:
3339:
3290:
3269:"Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity"
3241:
3181:
3131:
3082:
3033:
2970:
2926:
2891:
2842:
2813:"The Werner syndrome protein: linking the replication checkpoint response to genome stability"
2793:
2744:
2703:
2646:
2595:
2546:
2489:
2439:
2396:
2358:
2313:
2262:
2242:
2211:
2162:
2113:
2061:
2012:
1953:
1911:
1839:
1829:
1798:
1749:
1700:
1651:
1602:
1553:
1495:
1439:
1390:
1331:
1282:
1233:
659:" for a discussion of the evidence that DNA damage is the primary underlying cause of aging.)
652:
411:
383:
285:
140:
98:
38:
3755:"Bloom's syndrome. I. Genetical and clinical observations in the first twenty-seven patients"
5651:
5286:
5097:
5069:
4583:
4575:
4534:
4526:
4485:
4477:
4438:
4401:
4360:
4350:
4306:
4298:
4246:
4202:
4194:
4150:
4142:
4098:
4088:
4036:
3995:
3987:
3940:
3903:
3895:
3854:
3846:
3807:
3766:
3725:
3715:
3666:
3658:
3617:
3576:
3566:
3524:
3475:
3433:
3396:
3388:
3377:"Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks"
3329:
3280:
3233:
3223:
3171:
3121:
3074:
3025:
2962:
2918:
2881:
2873:
2832:
2824:
2783:
2775:
2734:
2693:
2685:
2636:
2626:
2585:
2577:
2536:
2528:
2479:
2431:
2388:
2348:
2340:
2331:
Bonsignore LA, Tooley JG, Van Hoose PM, Wang E, Cheng A, Cole MP, Schaner Tooley CE (2015).
2303:
2293:
2252:
2234:
2201:
2193:
2152:
2144:
2103:
2095:
2051:
2043:
2002:
1992:
1945:
1901:
1893:
1821:
1788:
1780:
1739:
1731:
1690:
1682:
1641:
1633:
1592:
1584:
1543:
1535:
1485:
1477:
1429:
1421:
1380:
1370:
1321:
1313:
1272:
1264:
1223:
1213:
1175:
693:
435:
2666:"WRN regulates pathway choice between classical and alternative non-homologous end joining"
2182:"Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer"
1882:"Elements That Regulate the DNA Damage Response of Proteins Defective in Cockayne Syndrome"
1516:"Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice"
5849:
5674:
5192:
3041:
1863:
1820:. Progress in Nucleic Acid Research and Molecular Biology. Vol. 68. pp. 139â49.
1818:
Factors influencing the removal of thymine glycol from DNA in gamma-irradiated human cells
1142:
697:
190:
Table 1. DNA repair proteins that, when deficient, cause features of accelerated aging (
166:
102:
2764:"Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage"
1302:"Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice"
696:
associated with increased mortality, but not associated with an aging phenotype, such as
3884:"Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging"
3711:
3148:
Hoeijmakers JH. DNA damage, aging, and cancer. N Engl J Med. 2009 Oct 8;361(15):1475-85.
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1531:
1425:
1366:
5789:
5774:
5707:
5489:
5460:
5310:
5274:
5228:
5187:
4883:
4806:
4588:
4563:
4539:
4514:
4490:
4465:
4365:
4338:
4311:
4286:
4207:
4182:
4155:
4130:
4103:
4076:
4000:
3975:
3908:
3883:
3859:
3834:
3771:
3754:
3730:
3695:
3671:
3646:
3581:
3554:
3401:
3376:
2886:
2861:
2837:
2812:
2788:
2763:
2698:
2665:
2641:
2614:
2541:
2516:
2466:
Barrett, JC; Guarente, L; Mulligan, R; Demple, B; Yancopoulos, GD; Alt, FW (Jan 2006).
2353:
2332:
2308:
2281:
2257:
2206:
2181:
2157:
2132:
2108:
2083:
2056:
2031:
2007:
1980:
1906:
1881:
1744:
1719:
1646:
1621:
1597:
1572:
1548:
1515:
1490:
1465:
1434:
1409:
1385:
1350:
1326:
1301:
1277:
1252:
1228:
1201:
1160:
926:
871:
677:
145:
135:
3528:
2590:
2565:
2422:
Chalkiadaki A, Guarente L (2015). "The multifaceted functions of sirtuins in cancer".
1825:
1793:
1768:
1695:
1670:
5843:
5636:
5556:
5140:
4146:
3944:
3696:"Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair"
3334:
3317:
3285:
3268:
3228:
2581:
2517:"SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair"
738:
43:
4198:
4058:
3960:
3850:
3497:
3351:
3302:
3253:
3193:
2982:
2938:
2501:
2408:
1965:
1686:
5641:
5631:
5567:
5548:
4798:
4268:
2451:
1134:
673:
407:
391:
379:
363:
4406:
4389:
3094:
600:
shorter lifespan, earlier onset of aging related pathologies, genome instability
113:
display different aspects of aging, but never every aspect, they are often called
4635:
4481:
3991:
3811:
3662:
3392:
2877:
2238:
1997:
1735:
1637:
1481:
1375:
1351:"The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency"
5804:
5512:
Keratosis linearis with ichthyosis congenita and sclerosing keratoderma syndrome
5413:
5292:
5268:
4530:
4339:"MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA"
3437:
2468:"Genomic instability and aging-like phenotype in the absence of mammalian SIRT6"
1004:
490:; aspects of premature aging; altered expression of numerous DNA repair factors
402:
premature aging features with shorter life span and photosensitivity, deficient
374:
premature aging features with shorter life span and photosensitivity, deficient
118:
4442:
4302:
4287:"Endometrial cancer and Lynch syndrome: clinical and pathologic considerations"
3835:"Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology"
3553:
Chrzanowska KH, Gregorek H, Dembowska-BagiĆska B, Kalina MA, Digweed M (2012).
3176:
3159:
2484:
2467:
1300:
Espejel S, MartĂn M, Klatt P, MartĂn-Caballero J, Flores JM, Blasco MA (2004).
1268:
5562:
5157:
4794:
3899:
2922:
2392:
2344:
2148:
2099:
1949:
1897:
1180:
1021:
946:
936:
747:
725:
106:
64:
4579:
4355:
1317:
5824:
3720:
3078:
2631:
2532:
2298:
1466:"Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease"
688:
4597:
4548:
4499:
4450:
4415:
4374:
4320:
4260:
4216:
4164:
4112:
4093:
4050:
4009:
3952:
3917:
3868:
3819:
3739:
3680:
3631:
3590:
3571:
3536:
3489:
3445:
3410:
3343:
3294:
3245:
3185:
3135:
3126:
3109:
3086:
3037:
2974:
2930:
2895:
2846:
2797:
2748:
2739:
2722:
2707:
2650:
2599:
2550:
2493:
2443:
2400:
2362:
2317:
2266:
2215:
2166:
2117:
2065:
2016:
1957:
1915:
1843:
1784:
1753:
1704:
1655:
1606:
1557:
1499:
1443:
1394:
1335:
1286:
1237:
3780:
3029:
2828:
1802:
1588:
921:
basal cell carcinoma, squamous cell carcinoma, intraepidermal carcinoma
5542:
5427:
5239:
3480:
3463:
3462:
Keimling M, Volcic M, Csernok A, Wieland B, Dörk T, WiesmĂŒller L (2011).
3237:
2779:
2197:
2047:
1218:
877:
751:
733:
687:
Against this position other biogerontologists argue that premature aging
669:
605:
487:
226:
150:
4622:
3694:
Nimonkar AV, Ozsoy AZ, Genschel J, Modrich P, Kowalczykowski SC (2008).
2689:
1539:
1118:
sarcomas, breast cancers, brain tumors, and adrenocortical carcinomas
91:
DNA repair defects are seen in nearly all of the diseases described as
4251:
4234:
4041:
4024:
3796:"Deficient DNA repair in the human progeroid disorder, Werner syndrome"
3318:"Rebuttal to Miller: 'Accelerated aging': a primrose path to insight?'"
1093:
434:
mutations have a partially inactivated protein with retarded repair of
4129:
Oh KS, Imoto K, Emmert S, Tamura D, DiGiovanna JJ, Kraemer KH (2011).
3622:
3605:
2664:
Shamanna RA, Lu H, de
Freitas JK, Tian J, Croteau DL, Bohr VA (2016).
5587:
Template:Congenital malformations and deformations of skin appendages
5471:
2030:
Theil AF, Nonnekens J, Wijgers N, Vermeulen W, Giglia-Mari G (2011).
910:
858:
853:
838:
755:
729:
709:
636:
508:
419:
3795:
3512:
2862:"Roles of Werner syndrome protein in protection of genome integrity"
2435:
4466:"Connecting molecular pathways to hereditary cancer risk syndromes"
4183:"DNA repair diseases: What do they tell us about cancer and aging?"
2966:
1573:"Broad segmental progeroid changes in short-lived Ercc1(-/Î7) mice"
18:
Inherited human DNA repair gene mutations that increase cancer risk
5661:
1123:
1084:
982:
978:
784:
781:
566:
539:
339:
306:
268:
241:
2233:. Methods in Molecular Biology. Vol. 1411. pp. 419â37.
2564:
Saintigny Y, Makienko K, Swanson C, Emond MJ, Monnat RJ (2002).
2131:
Ahmed EA, VĂ©laz E, Rosemann M, Gilbertz KP, Scherthan H (2017).
1062:
1059:
1056:
1053:
950:
644:
628:
472:
457:
442:
5320:
Focal palmoplantar keratoderma with oral mucosal hyperkeratosis
4763:
4740:
DNA repair and toxicology - Companion
Reviews and Search Terms
3110:"Activation of human MutS homologs by 8-oxo-guanine DNA damage"
2566:"Homologous recombination resolution defect in werner syndrome"
1107:
974:
970:
655:
rather than as cancer or "accelerated aging". (Also see the "
70:
4750:
Neoplasia carcinogenesis - Companion
Reviews and Search Terms
2811:
Pichierri P, Ammazzalorso F, Bignami M, Franchitto A (2011).
962:, repairs damage in both transcribed and untranscribed DNA
334:, muscle wasting, osteopenia, kyphosis and cerebral atrophy
905:
soft tissue sarcoma, colorectal, skin, thyroid, pancreas
301:) and with extreme sun-mediated skin cancer predisposition
623:
DNA repair defects distinguished from "accelerated aging"
5735:
Congenital hypertrophy of the lateral fold of the hallux
4745:
Neoplasia inherited - Companion Reviews and Search Terms
5603:
Template:DNA replication and repair-deficiency disorder
63:
is a medical condition due to reduced functionality of
4675:
Bloom s syndrome - Companion Reviews and Search Terms
1669:
Tian M, Jones DA, Smith M, Shinkura R, Alt FW (2004).
4680:
Fanconi s anemia - Companion Reviews and Search Terms
1026:skin cancers (basal cell, squamous cell, melanoma)
4612:
3160:"Defective DNA repair and neurodegenerative disease"
5690:
5660:
5624:
5615:
5534:
5453:
5200:
5186:
5139:
5088:
4965:
4915:
4897:
4846:
4828:
4814:
4805:
4616:
37:
32:
3209:"'Accelerated aging': a primrose path to insight?"
2280:Cai Q, Fu L, Wang Z, Gan N, Dai X, Wang Y (2014).
941:leukemia, liver tumors, solid tumors many areas
929:genes FANCA, B, C, D1, D2, E, F, G, I, J, L, M, N
5219:Diffuse nonepidermolytic palmoplantar keratoderma
2180:Li H, Vogel H, Holcomb VB, Gu Y, Hasty P (2007).
792:of double strand breaks and daughter strand gaps
486:increased DNA damage and chromosome aberrations;
4943:Nonbullous congenital ichthyosiform erythroderma
5865:DNA replication and repair-deficiency disorders
5408:Palmoplantar keratoderma and spastic paraplegia
3108:Mazurek A, Berardini M, Fishel R (March 2002).
3001:"Nuclear DNA damage as a direct cause of aging"
1464:Gregg SQ, Robinson AR, Niedernhofer LJ (2011).
5214:Diffuse epidermolytic palmoplantar keratoderma
3513:"Recombinational DNA repair and human disease"
5745:Congenital malformations of the dermatoglyphs
4775:
8:
4075:Lehmann AR, McGibbon D, Stefanini M (2011).
1001:strands of transcriptionally active genes
724:Individuals with an inherited impairment in
720:DNA repair defects and increased cancer risk
643:(HNPCC) is very often caused by a defective
182:Some examples of DNA repair defects causing
4735:MUTYH - Companion Reviews and Search Terms
4710:FANCN - Companion Reviews and Search Terms
4695:RECQL4 - Companion Reviews and Search Terms
4660:BRCA2 - Companion Reviews and Search Terms
4655:BRCA1 - Companion Reviews and Search Terms
3457:
3455:
1931:
1929:
1927:
1925:
5770:Melanotic neuroectodermal tumor of infancy
5621:
5507:Keratosis follicularis spinulosa decalvans
5197:
4938:Ichthyosisâsclerosing cholangitis syndrome
4825:
4811:
4782:
4768:
4760:
4730:MSH6 - Companion Reviews and Search Terms
4705:FANCM - Companion Reviews and Search Terms
4700:FANCJ - Companion Reviews and Search Terms
4670:NBS1 - Companion Reviews and Search Terms
4613:
4070:
4068:
3548:
3546:
3158:Rass U, Ahel I, West SC (September 2007).
2077:
2075:
965:skin cancer (melanoma and non-melanoma)
743:
728:capability are often at increased risk of
188:
48:
29:
5730:Congenital cartilaginous rest of the neck
5325:Focal palmoplantar and gingival keratosis
4725:XPG - Companion Reviews and Search Terms
4720:XPD - Companion Reviews and Search Terms
4715:XPB - Companion Reviews and Search Terms
4665:ATM - Companion Reviews and Search Terms
4650:BRCA - Companion Reviews and Search Terms
4587:
4538:
4489:
4464:Testa JR, Malkin D, Schiffman JD (2013).
4405:
4364:
4354:
4310:
4250:
4206:
4154:
4102:
4092:
4040:
3999:
3907:
3858:
3770:
3729:
3719:
3670:
3621:
3580:
3570:
3479:
3400:
3333:
3284:
3227:
3175:
3125:
3019:
2885:
2836:
2787:
2738:
2697:
2640:
2630:
2589:
2540:
2483:
2352:
2307:
2297:
2256:
2205:
2156:
2107:
2055:
2006:
1996:
1905:
1792:
1743:
1694:
1645:
1596:
1547:
1489:
1433:
1384:
1374:
1325:
1276:
1227:
1217:
641:Hereditary nonpolyposis colorectal cancer
5795:Rapidly involuting congenital hemangioma
5385:Keratosis punctata of the palmar creases
5380:Keratosis punctata palmaris et plantaris
5251:Clouston's hidrotic ectodermal dysplasia
4690:RECQ- Companion Reviews and Search Terms
4685:WRN - Companion Reviews and Search Terms
4337:Markkanen E, Dorn J, HĂŒbscher U (2013).
4280:
4278:
4176:
4174:
1875:
1873:
186:in humans or mice are shown in Table 1.
87:DNA repair defects and accelerated aging
4332:
4330:
4228:
4226:
2994:
2992:
1459:
1457:
1455:
1453:
1192:
1131:BER for Tg, FapyG, 5-hC, 5-hU in dsDNA
2374:
2372:
1859:
1849:
676:, etc., are associated with increased
153:(HutchinsonâGilford progeria syndrome)
125:Human disorders with accelerated aging
4856:Congenital ichthyosiform erythroderma
4564:"NTHL1 defines novel cancer syndrome"
4285:Meyer LA, Broaddus RR, Lu KH (2009).
4124:
4122:
4025:"Cancer in Fanconi anemia, 1927-2001"
2082:Holcomb VB, Vogel H, Hasty P (2007).
1045:postmeiotic segregation increased 2 (
663:Debate concerning "accelerated aging"
7:
5517:Keratosis pilaris atrophicans faciei
5102:Dermatopathia pigmentosa reticularis
2860:Rossi ML, Ghosh AK, Bohr VA (2010).
1426:10.1016/j.freeradbiomed.2010.02.033
5810:Superficial lymphatic malformation
5755:Congenital smooth muscle hamartoma
5224:Palmoplantar keratoderma of Sybert
4793:malformations and deformations of
4562:Kuiper RP, Hoogerbrugge N (2015).
3555:"Nijmegen breakage syndrome (NBS)"
325:Microhomology-mediated end joining
25:
5282:Scleroatrophic syndrome of Huriez
5112:Hypohidrotic ectodermal dysplasia
3882:Singh DK, Ahn B, Bohr VA (2009).
350:Homologous recombinational repair
5395:Porokeratosis plantaris discreta
5352:Striate palmoplantar keratoderma
4147:10.1111/j.1751-1097.2011.00909.x
3945:10.1097/00003086-200009000-00032
3335:10.1111/j.1474-9728.2004.00087.x
3286:10.1111/j.1474-9728.2004.00082.x
3229:10.1111/j.1474-9728.2004.00081.x
2582:10.1128/mcb.22.20.6971-6978.2002
918:Helicase likely active in HRR
5820:Verrucous vascular malformation
5750:Congenital preauricular fistula
5720:Accessory nail of the fifth toe
5597:Template:Pigmentation disorders
5390:SchöpfâSchulzâPassarge syndrome
5370:Acrokeratoelastoidosis of Costa
5075:Laryngoonychocutaneous syndrome
4948:Ichthyosis linearis circumflexa
4933:Ichthyosis prematurity syndrome
4199:10.1590/s1415-47572014000200008
3851:10.1016/j.semcancer.2010.10.002
1687:10.1128/MCB.24.6.2237-2242.2004
277:(also transcription as part of
5434:Erythrokeratodermia variabilis
5345:Pachyonychia congenita type II
4519:Cold Spring Harb Perspect Biol
3511:Thompson LH, Schild D (2002).
3316:Hasty P, Vijg J (April 2004).
3267:Hasty P, Vijg J (April 2004).
1007:(melanoma and non-melanoma)
597:, Replication arrest recovery
394:(Cockayne syndrome A or CS-A)
366:(Cockayne syndrome B or CS-B)
284:some mutations in ERCC2 cause
61:DNA repair-deficiency disorder
33:DNA repair-deficiency disorder
1:
5760:Cystic lymphatic malformation
5713:Cavernous venous malformation
5340:Pachyonychia congenita type I
5263:Corneodermatoosseous syndrome
4923:Ichthyosis bullosa of Siemens
4431:Biochem. Biophys. Res. Commun
4407:10.1158/1541-7786.MCR-08-0020
3974:Thompson LH, Hinz JM (2009).
3529:10.1016/s0027-5107(02)00224-5
3375:Nagaraju G, Scully R (2007).
1826:10.1016/S0079-6603(01)68096-6
1577:Pathobiol Aging Age Relat Dis
828:leukemia, lymphoma, breast
801:ataxia telangiectasia mutated
317:Interstrand cross link repair
251:Interstrand cross link repair
105:or systems of the human body
5168:Popliteal pterygium syndrome
4860:Epidermolytic hyperkeratosis
4513:Krokan HE, BjÞrÄs M (2013).
4482:10.1200/EdBook_AM.2013.33.81
4181:Menck CF, Munford V (2014).
3992:10.1016/j.mrfmmm.2009.02.003
3812:10.1016/j.mrfmmm.2005.03.021
3700:Proc. Natl. Acad. Sci. U.S.A
3663:10.1016/j.molonc.2008.09.007
3604:Rapp A, Greulich KO (2004).
3393:10.1016/j.dnarep.2007.02.020
2878:10.1016/j.dnarep.2009.12.011
2239:10.1007/978-1-4939-3530-7_26
1998:10.1371/journal.pgen.1003431
1736:10.1016/j.molcel.2015.12.026
1638:10.1016/j.dnarep.2011.04.028
1482:10.1016/j.dnarep.2011.04.026
1376:10.1371/journal.pone.0093568
773:Cancers with increased risk
73:repair defects can cause an
5800:RosenthalâKloepfer syndrome
5785:Omphalomesenteric duct cyst
5502:Keratolytic winter erythema
5162:Gerodermia osteodysplastica
4531:10.1101/cshperspect.a012583
4470:Am Soc Clin Oncol Educ Book
3438:10.1016/j.ygyno.2014.09.009
1880:Iyama T, Wilson DM (2016).
1620:Fuss JO, Tainer JA (2011).
1022:Translesion synthesis (TLS)
1015:(also called polymerase H)
5891:
5375:Focal acral hyperkeratosis
5122:Ellisâvan Creveld syndrome
4443:10.1016/j.bbrc.2005.03.192
4303:10.1177/107327480901600103
3177:10.1016/j.cell.2007.08.043
2485:10.1016/j.cell.2005.11.044
1269:10.1016/j.stem.2007.03.002
1171:DNA damage theory of aging
1072:colorectal, endometrial
834:Nijmegen breakage syndrome
657:DNA damage theory of aging
647:gene leading to defective
591:Non-homologous end joining
572:Non-homologous end joining
557:Non-homologous end joining
549:Nucleotide excision repair
526:Non-homologous end joining
518:Nucleotide excision repair
499:Nucleotide excision repair
478:Non-homologous end joining
463:Non-homologous end joining
448:Non-homologous end joining
426:Nucleotide excision repair
398:Nucleotide excision repair
370:Nucleotide excision repair
346:Nucleotide excision repair
313:Nucleotide excision repair
275:Nucleotide excision repair
247:Nucleotide excision repair
232:Non-homologous end joining
216:Nucleotide excision repair
111:accelerated aging diseases
5299:PapillonâLefĂšvre syndrome
4870:Harlequin-type ichthyosis
3900:10.1007/s10522-008-9205-z
2923:10.1016/j.arr.2014.12.006
2393:10.1016/j.arr.2016.06.002
2345:10.1016/j.mad.2015.03.012
2149:10.1007/s00412-016-0590-9
2100:10.1016/j.mad.2007.08.006
1950:10.1016/j.mad.2013.03.006
1898:10.1016/j.jmb.2015.11.020
1200:Park JM, Kang TH (2016).
995:Transcription coupled NER
772:
770:Repair pathways affected
769:
763:
706:aging-associated diseases
404:transcription coupled NER
376:transcription coupled NER
257:transcription coupled NER
157:RothmundâThomson syndrome
109:prematurely. Because the
94:accelerated aging disease
76:accelerated aging disease
5173:Pseudoxanthoma elasticum
4889:SjögrenâLarsson syndrome
4580:10.18632/oncotarget.5864
4356:10.3389/fgene.2013.00018
3933:Clin. Orthop. Relat. Res
3207:Miller RA (April 2004).
1318:10.1038/sj.embor.7400127
778:breast cancer 1 & 2
766:
611:Homologous recombination
587:Homologous recombination
582:Werner syndrome helicase
553:Homologous recombination
522:Homologous recombination
482:Homologous recombination
81:increased risk of cancer
5698:Aplasia cutis congenita
5117:Focal dermal hypoplasia
5080:Skin fragility syndrome
4928:Ichthyosis follicularis
4077:"Xeroderma pigmentosum"
3721:10.1073/pnas.0809380105
3079:10.1126/science.1079161
2632:10.1074/jbc.M114.578823
2533:10.15252/embj.201593499
2299:10.1074/jbc.M114.558510
810:Different mutations in
321:Single-strand annealing
5815:Thyroglossal duct cyst
5780:Nasolacrimal duct cyst
5703:Amniotic band syndrome
5497:Dyskeratosis congenita
5485:Dyskeratosis congenita
5335:Pachyonychia congenita
5246:BartâPumphrey syndrome
5178:Van der Woude syndrome
5153:EhlersâDanlos syndrome
4515:"Base excision repair"
4094:10.1186/1750-1172-6-70
3572:10.1186/1750-1172-7-13
3127:10.1074/jbc.M111269200
2740:10.1074/jbc.M703343200
899:HRR, NHEJ, long patch
332:chronic kidney disease
5680:Nevus flammeus nuchae
5591:Template:Phakomatoses
5563:Hereditary lymphedema
5127:RappâHodgkin syndrome
4816:Congenital ichthyosis
3030:10.1089/rej.2009.0847
3008:Rejuvenation Research
2829:10.18632/aging.100293
1589:10.3402/pba.v1i0.7219
1414:Free Radic. Biol. Med
295:xeroderma pigmentosum
172:Xeroderma pigmentosum
131:Ataxia-telangiectasia
83:, or sometimes both.
5870:Causes of conditions
5670:Capillary hemangioma
5572:Urticaria pigmentosa
5330:HowelâEvans syndrome
5090:Ectodermal dysplasia
5031:Generalized atrophic
4135:Photochem. Photobiol
3481:10.1096/fj.11-185546
2231:The Nuclear Envelope
2198:10.1128/MCB.00785-07
2048:10.1128/MCB.01462-10
1785:10.1093/nar/27.4.979
1219:10.3390/ijms17111840
1166:Degenerative disease
1147:basal-cell carcinoma
991:XPA XPB XPD XPF XPG
633:base excision repair
595:Base excision repair
545:Base excision repair
514:Base excision repair
354:Base excision repair
5357:Tyrosinemia type II
4907:X-linked ichthyosis
4865:Lamellar ichthyosis
4838:Ichthyosis vulgaris
4821:erythrokeratodermia
4193:(1 Suppl): 220â33.
4081:Orphanet J Rare Dis
3712:2008PNAS..10516906N
3559:Orphanet J Rare Dis
2690:10.1038/ncomms13785
2682:2016NatCo...713785S
1540:10.1038/nature19329
1532:2016Natur.537..427V
1367:2014PLoSO...993568R
1039:) homolog 6, mutL (
1035:) homolog 2, mutS (
848:lymphoid cancers
760:
714:Alzheimer's disease
682:biomarkers of aging
680:. Without reliable
674:high blood pressure
291:trichothiodystrophy
195:
184:progeroid syndromes
162:Trichothiodystrophy
115:segmental progerias
97:, in which various
5740:Congenital lip pit
5304:HaimâMunk syndrome
5256:Vohwinkel syndrome
5131:HayâWells syndrome
5107:HayâWells syndrome
4953:Ichthyosis hystrix
4879:Netherton syndrome
4755:Segmental Progeria
4388:Kastan MB (2008).
4252:10.1002/humu.22462
4042:10.1002/cncr.11046
3839:Semin. Cancer Biol
3833:Monnat RJ (2010).
3616:(Pt 21): 4935â45.
3381:DNA Repair (Amst.)
2866:DNA Repair (Amst.)
2780:10.1093/nar/gks648
2339:. 146â148: 42â52.
1626:DNA Repair (Amst.)
1470:DNA Repair (Amst.)
1139:endometrial cancer
960:Global genomic NER
795:breast, ovarian
744:
702:sickle cell anemia
299:progeroid syndrome
192:segmental progeria
189:
5837:
5836:
5833:
5832:
5765:Median raphe cyst
5725:Bronchogenic cyst
5647:PHACE association
5611:
5610:
5530:
5529:
5522:Keratosis pilaris
5466:Keratosis pilaris
5420:Carvajal syndrome
5400:Spiny keratoderma
5065:Costello syndrome
4961:
4960:
4645:
4644:
4023:Alter BP (2003).
3759:Am. J. Hum. Genet
3753:German J (1969).
3623:10.1242/jcs.01355
2999:Best, BP (2009).
2768:Nucleic Acids Res
2733:(36): 26591â602.
2248:978-1-4939-3528-4
1773:Nucleic Acids Res
1767:Bessho T (1999).
1526:(7620): 427â431.
1152:
1151:
653:neurodegeneration
620:
619:
436:6-4-photoproducts
414:and cyclopurines
412:5-hydroxycytosine
386:and cyclopurines
384:5-hydroxycytosine
286:Cockayne syndrome
141:Cockayne syndrome
119:biogerontologists
57:
56:
27:Medical condition
16:(Redirected from
5882:
5652:Sinus pericranii
5622:
5478:Darier's disease
5287:Olmsted syndrome
5198:
5098:Naegeli syndrome
5070:Kindler syndrome
4826:
4812:
4784:
4777:
4770:
4761:
4614:
4602:
4601:
4591:
4574:(33): 34069â70.
4559:
4553:
4552:
4542:
4510:
4504:
4503:
4493:
4461:
4455:
4454:
4426:
4420:
4419:
4409:
4385:
4379:
4378:
4368:
4358:
4334:
4325:
4324:
4314:
4282:
4273:
4272:
4254:
4230:
4221:
4220:
4210:
4187:Genet. Mol. Biol
4178:
4169:
4168:
4158:
4126:
4117:
4116:
4106:
4096:
4072:
4063:
4062:
4044:
4020:
4014:
4013:
4003:
3971:
3965:
3964:
3928:
3922:
3921:
3911:
3879:
3873:
3872:
3862:
3830:
3824:
3823:
3794:Bohr VA (2005).
3791:
3785:
3784:
3774:
3750:
3744:
3743:
3733:
3723:
3706:(44): 16906â11.
3691:
3685:
3684:
3674:
3642:
3636:
3635:
3625:
3601:
3595:
3594:
3584:
3574:
3550:
3541:
3540:
3508:
3502:
3501:
3483:
3459:
3450:
3449:
3421:
3415:
3414:
3404:
3372:
3366:
3362:
3356:
3355:
3337:
3313:
3307:
3306:
3288:
3264:
3258:
3257:
3231:
3213:
3204:
3198:
3197:
3179:
3155:
3149:
3146:
3140:
3139:
3129:
3105:
3099:
3098:
3073:(5611): 1355â9.
3062:
3056:
3055:
3053:
3052:
3046:
3040:. Archived from
3023:
3005:
2996:
2987:
2986:
2949:
2943:
2942:
2906:
2900:
2899:
2889:
2857:
2851:
2850:
2840:
2808:
2802:
2801:
2791:
2759:
2753:
2752:
2742:
2718:
2712:
2711:
2701:
2661:
2655:
2654:
2644:
2634:
2625:(39): 27314â26.
2610:
2604:
2603:
2593:
2561:
2555:
2554:
2544:
2527:(14): 1488â503.
2512:
2506:
2505:
2487:
2462:
2456:
2455:
2424:Nat. Rev. Cancer
2419:
2413:
2412:
2376:
2367:
2366:
2356:
2337:Mech. Ageing Dev
2328:
2322:
2321:
2311:
2301:
2292:(23): 16046â56.
2277:
2271:
2270:
2260:
2226:
2220:
2219:
2209:
2177:
2171:
2170:
2160:
2128:
2122:
2121:
2111:
2094:(11â12): 601â8.
2088:Mech. Ageing Dev
2079:
2070:
2069:
2059:
2027:
2021:
2020:
2010:
2000:
1976:
1970:
1969:
1938:Mech. Ageing Dev
1933:
1920:
1919:
1909:
1877:
1868:
1867:
1861:
1857:
1855:
1847:
1813:
1807:
1806:
1796:
1764:
1758:
1757:
1747:
1715:
1709:
1708:
1698:
1666:
1660:
1659:
1649:
1617:
1611:
1610:
1600:
1568:
1562:
1561:
1551:
1510:
1504:
1503:
1493:
1461:
1448:
1447:
1437:
1405:
1399:
1398:
1388:
1378:
1346:
1340:
1339:
1329:
1297:
1291:
1290:
1280:
1248:
1242:
1241:
1231:
1221:
1197:
1176:Genetic disorder
764:DNA repair gene
761:
694:genetic diseases
196:
53:
52:
30:
21:
5890:
5889:
5885:
5884:
5883:
5881:
5880:
5879:
5840:
5839:
5838:
5829:
5691:Other/ungrouped
5686:
5675:Port-wine stain
5656:
5617:
5607:
5526:
5449:
5191:
5182:
5135:
5084:
4969:
4957:
4911:
4893:
4842:
4819:
4801:
4788:
4646:
4641:
4640:
4625:
4611:
4606:
4605:
4561:
4560:
4556:
4512:
4511:
4507:
4463:
4462:
4458:
4428:
4427:
4423:
4394:Mol. Cancer Res
4387:
4386:
4382:
4336:
4335:
4328:
4284:
4283:
4276:
4232:
4231:
4224:
4180:
4179:
4172:
4128:
4127:
4120:
4074:
4073:
4066:
4022:
4021:
4017:
3973:
3972:
3968:
3939:(378): 213â23.
3930:
3929:
3925:
3881:
3880:
3876:
3832:
3831:
3827:
3793:
3792:
3788:
3752:
3751:
3747:
3693:
3692:
3688:
3644:
3643:
3639:
3603:
3602:
3598:
3552:
3551:
3544:
3510:
3509:
3505:
3474:(11): 3849â60.
3461:
3460:
3453:
3423:
3422:
3418:
3374:
3373:
3369:
3363:
3359:
3315:
3314:
3310:
3266:
3265:
3261:
3211:
3206:
3205:
3201:
3170:(6): 991â1004.
3157:
3156:
3152:
3147:
3143:
3107:
3106:
3102:
3064:
3063:
3059:
3050:
3048:
3044:
3003:
2998:
2997:
2990:
2951:
2950:
2946:
2917:(Pt A): 12â28.
2911:Ageing Res. Rev
2908:
2907:
2903:
2859:
2858:
2854:
2810:
2809:
2805:
2774:(17): 8449â59.
2761:
2760:
2756:
2720:
2719:
2715:
2663:
2662:
2658:
2612:
2611:
2607:
2570:Mol. Cell. Biol
2563:
2562:
2558:
2514:
2513:
2509:
2464:
2463:
2459:
2436:10.1038/nrc3985
2421:
2420:
2416:
2381:Ageing Res. Rev
2378:
2377:
2370:
2330:
2329:
2325:
2279:
2278:
2274:
2249:
2228:
2227:
2223:
2192:(23): 8205â14.
2186:Mol. Cell. Biol
2179:
2178:
2174:
2130:
2129:
2125:
2081:
2080:
2073:
2036:Mol. Cell. Biol
2029:
2028:
2024:
1991:(4): e1003431.
1978:
1977:
1973:
1935:
1934:
1923:
1879:
1878:
1871:
1858:
1848:
1836:
1815:
1814:
1810:
1766:
1765:
1761:
1717:
1716:
1712:
1675:Mol. Cell. Biol
1668:
1667:
1663:
1619:
1618:
1614:
1570:
1569:
1565:
1512:
1511:
1507:
1463:
1462:
1451:
1420:(10): 1435â43.
1407:
1406:
1402:
1348:
1347:
1343:
1299:
1298:
1294:
1250:
1249:
1245:
1199:
1198:
1194:
1189:
1157:
1143:duodenal cancer
863:HRR and NHEJ
722:
698:cystic fibrosis
665:
649:mismatch repair
631:essential for
625:
180:
167:Werner syndrome
127:
89:
47:
28:
23:
22:
15:
12:
11:
5:
5888:
5886:
5878:
5877:
5872:
5867:
5862:
5857:
5852:
5842:
5841:
5835:
5834:
5831:
5830:
5828:
5827:
5822:
5817:
5812:
5807:
5802:
5797:
5792:
5790:Poland anomaly
5787:
5782:
5777:
5775:Mongolian spot
5772:
5767:
5762:
5757:
5752:
5747:
5742:
5737:
5732:
5727:
5722:
5716:
5715:
5710:
5708:Branchial cyst
5705:
5700:
5694:
5692:
5688:
5687:
5685:
5684:
5683:
5682:
5672:
5666:
5664:
5658:
5657:
5655:
5654:
5649:
5644:
5639:
5634:
5628:
5626:
5619:
5613:
5612:
5609:
5608:
5582:
5581:
5576:
5575:
5574:
5565:
5553:
5552:
5551:
5538:
5536:
5532:
5531:
5528:
5527:
5525:
5524:
5519:
5514:
5509:
5504:
5499:
5493:
5492:
5490:Lelis syndrome
5487:
5482:
5481:
5480:
5468:
5463:
5461:Meleda disease
5457:
5455:
5451:
5450:
5448:
5447:
5446:
5445:
5436:
5424:
5423:
5422:
5410:
5403:
5402:
5397:
5392:
5387:
5382:
5377:
5372:
5362:
5361:
5360:
5359:
5354:
5349:
5348:
5347:
5342:
5332:
5327:
5322:
5313:
5311:Camisa disease
5308:
5307:
5306:
5301:
5289:
5284:
5279:
5278:
5277:
5275:Naxos syndrome
5265:
5260:
5259:
5258:
5253:
5248:
5232:
5231:
5229:Meleda disease
5226:
5221:
5216:
5206:
5204:
5195:
5188:Hyperkeratosis
5184:
5183:
5181:
5180:
5175:
5170:
5165:
5155:
5149:
5147:
5137:
5136:
5134:
5133:
5124:
5119:
5114:
5109:
5104:
5094:
5092:
5086:
5085:
5083:
5082:
5077:
5072:
5067:
5060:
5059:
5058:
5057:
5052:
5041:
5040:
5039:
5038:
5033:
5028:
5023:
5012:
5011:
5010:
5009:
5004:
4999:
4994:
4989:
4984:
4973:
4971:
4963:
4962:
4959:
4958:
4956:
4955:
4950:
4945:
4940:
4935:
4930:
4925:
4919:
4917:
4913:
4912:
4910:
4909:
4903:
4901:
4895:
4894:
4892:
4891:
4886:
4884:CHIME syndrome
4881:
4875:
4874:
4873:
4872:
4862:
4852:
4850:
4844:
4843:
4841:
4840:
4834:
4832:
4823:
4809:
4807:Genodermatosis
4803:
4802:
4789:
4787:
4786:
4779:
4772:
4764:
4758:
4757:
4752:
4747:
4742:
4737:
4732:
4727:
4722:
4717:
4712:
4707:
4702:
4697:
4692:
4687:
4682:
4677:
4672:
4667:
4662:
4657:
4652:
4643:
4642:
4639:
4638:
4626:
4621:
4620:
4618:
4617:Classification
4610:
4609:External links
4607:
4604:
4603:
4554:
4525:(4): a012583.
4505:
4456:
4421:
4380:
4326:
4291:Cancer Control
4274:
4222:
4170:
4118:
4064:
4015:
3986:(1â2): 54â72.
3966:
3923:
3888:Biogerontology
3874:
3825:
3806:(1â2): 252â9.
3786:
3765:(2): 196â227.
3745:
3686:
3657:(4): 296â316.
3637:
3596:
3542:
3523:(1â2): 49â78.
3503:
3451:
3426:Gynecol. Oncol
3416:
3387:(7): 1018â31.
3367:
3357:
3308:
3259:
3199:
3150:
3141:
3120:(10): 8260â6.
3100:
3057:
3021:10.1.1.318.738
3014:(3): 199â208.
2988:
2967:10.1038/nm1266
2944:
2901:
2852:
2803:
2754:
2713:
2656:
2605:
2576:(20): 6971â8.
2556:
2507:
2457:
2430:(10): 608â24.
2414:
2368:
2323:
2272:
2247:
2221:
2172:
2143:(2): 287â298.
2123:
2071:
2042:(17): 3630â8.
2022:
1971:
1944:(5â6): 261â9.
1921:
1869:
1860:|journal=
1834:
1808:
1759:
1710:
1681:(6): 2237â42.
1661:
1632:(7): 697â713.
1612:
1563:
1505:
1449:
1400:
1341:
1292:
1257:Cell Stem Cell
1243:
1191:
1190:
1188:
1185:
1184:
1183:
1178:
1173:
1168:
1163:
1161:Biogerontology
1156:
1153:
1150:
1149:
1132:
1129:
1126:
1120:
1119:
1116:
1113:
1110:
1104:
1103:
1100:
1087:
1082:
1077:mutY homolog (
1074:
1073:
1070:
1065:
1051:
1028:
1027:
1024:
1019:
1016:
1009:
1008:
1002:
992:
989:
967:
966:
963:
957:
954:
943:
942:
939:
933:
930:
927:Fanconi anemia
923:
922:
919:
916:
913:
907:
906:
903:
897:
894:
888:
887:
884:
881:
874:
872:Bloom syndrome
868:
867:
864:
861:
856:
850:
849:
846:
841:
836:
830:
829:
826:
808:
803:
797:
796:
793:
787:
779:
775:
774:
771:
768:
765:
754:that increase
721:
718:
664:
661:
624:
621:
618:
617:
613:
608:
602:
601:
598:
584:
578:
577:
574:
569:
563:
562:
559:
542:
536:
535:
528:
511:
505:
504:
501:
496:
492:
491:
484:
475:
469:
468:
465:
460:
454:
453:
450:
445:
439:
438:
428:
423:
416:
415:
400:
395:
388:
387:
372:
367:
360:
359:
356:
343:
336:
335:
327:
310:
303:
302:
282:
272:
265:
264:
253:
244:
238:
237:
234:
229:
223:
222:
218:
213:
207:
206:
203:
200:
179:
176:
175:
174:
169:
164:
159:
154:
148:
146:Fanconi anemia
143:
138:
136:Bloom syndrome
133:
126:
123:
88:
85:
55:
54:
41:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5887:
5876:
5873:
5871:
5868:
5866:
5863:
5861:
5858:
5856:
5853:
5851:
5848:
5847:
5845:
5826:
5823:
5821:
5818:
5816:
5813:
5811:
5808:
5806:
5803:
5801:
5798:
5796:
5793:
5791:
5788:
5786:
5783:
5781:
5778:
5776:
5773:
5771:
5768:
5766:
5763:
5761:
5758:
5756:
5753:
5751:
5748:
5746:
5743:
5741:
5738:
5736:
5733:
5731:
5728:
5726:
5723:
5721:
5718:
5717:
5714:
5711:
5709:
5706:
5704:
5701:
5699:
5696:
5695:
5693:
5689:
5681:
5678:
5677:
5676:
5673:
5671:
5668:
5667:
5665:
5663:
5659:
5653:
5650:
5648:
5645:
5643:
5640:
5638:
5637:Encephalocele
5635:
5633:
5630:
5629:
5627:
5623:
5620:
5616:Developmental
5614:
5606:
5605:
5604:
5599:
5598:
5593:
5592:
5588:
5580:
5579:HaileyâHailey
5577:
5573:
5569:
5566:
5564:
5561:
5560:
5559:
5558:
5557:immune system
5554:
5550:
5547:
5546:
5545:
5544:
5540:
5539:
5537:
5533:
5523:
5520:
5518:
5515:
5513:
5510:
5508:
5505:
5503:
5500:
5498:
5495:
5494:
5491:
5488:
5486:
5483:
5479:
5476:
5475:
5474:
5473:
5469:
5467:
5464:
5462:
5459:
5458:
5456:
5452:
5444:
5440:
5437:
5435:
5432:
5431:
5430:
5429:
5425:
5421:
5418:
5417:
5416:
5415:
5411:
5409:
5405:
5404:
5401:
5398:
5396:
5393:
5391:
5388:
5386:
5383:
5381:
5378:
5376:
5373:
5371:
5367:
5364:
5363:
5358:
5355:
5353:
5350:
5346:
5343:
5341:
5338:
5337:
5336:
5333:
5331:
5328:
5326:
5323:
5321:
5317:
5314:
5312:
5309:
5305:
5302:
5300:
5297:
5296:
5295:
5294:
5290:
5288:
5285:
5283:
5280:
5276:
5273:
5272:
5271:
5270:
5266:
5264:
5261:
5257:
5254:
5252:
5249:
5247:
5244:
5243:
5242:
5241:
5237:
5236:
5234:
5233:
5230:
5227:
5225:
5222:
5220:
5217:
5215:
5211:
5208:
5207:
5205:
5203:
5199:
5196:
5194:
5193:keratinopathy
5189:
5185:
5179:
5176:
5174:
5171:
5169:
5166:
5163:
5159:
5156:
5154:
5151:
5150:
5148:
5146:
5142:
5138:
5132:
5128:
5125:
5123:
5120:
5118:
5115:
5113:
5110:
5108:
5105:
5103:
5099:
5096:
5095:
5093:
5091:
5087:
5081:
5078:
5076:
5073:
5071:
5068:
5066:
5062:
5061:
5056:
5053:
5051:
5048:
5047:
5046:
5043:
5042:
5037:
5034:
5032:
5029:
5027:
5024:
5022:
5019:
5018:
5017:
5014:
5013:
5008:
5005:
5003:
5000:
4998:
4995:
4993:
4990:
4988:
4985:
4983:
4980:
4979:
4978:
4975:
4974:
4972:
4968:
4964:
4954:
4951:
4949:
4946:
4944:
4941:
4939:
4936:
4934:
4931:
4929:
4926:
4924:
4921:
4920:
4918:
4914:
4908:
4905:
4904:
4902:
4900:
4896:
4890:
4887:
4885:
4882:
4880:
4877:
4876:
4871:
4868:
4867:
4866:
4863:
4861:
4857:
4854:
4853:
4851:
4849:
4845:
4839:
4836:
4835:
4833:
4831:
4827:
4824:
4822:
4817:
4813:
4810:
4808:
4804:
4800:
4796:
4792:
4785:
4780:
4778:
4773:
4771:
4766:
4765:
4762:
4756:
4753:
4751:
4748:
4746:
4743:
4741:
4738:
4736:
4733:
4731:
4728:
4726:
4723:
4721:
4718:
4716:
4713:
4711:
4708:
4706:
4703:
4701:
4698:
4696:
4693:
4691:
4688:
4686:
4683:
4681:
4678:
4676:
4673:
4671:
4668:
4666:
4663:
4661:
4658:
4656:
4653:
4651:
4648:
4647:
4637:
4633:
4632:
4628:
4627:
4624:
4619:
4615:
4608:
4599:
4595:
4590:
4585:
4581:
4577:
4573:
4569:
4565:
4558:
4555:
4550:
4546:
4541:
4536:
4532:
4528:
4524:
4520:
4516:
4509:
4506:
4501:
4497:
4492:
4487:
4483:
4479:
4475:
4471:
4467:
4460:
4457:
4452:
4448:
4444:
4440:
4437:(3): 868â80.
4436:
4432:
4425:
4422:
4417:
4413:
4408:
4403:
4400:(4): 517â24.
4399:
4395:
4391:
4384:
4381:
4376:
4372:
4367:
4362:
4357:
4352:
4348:
4344:
4340:
4333:
4331:
4327:
4322:
4318:
4313:
4308:
4304:
4300:
4296:
4292:
4288:
4281:
4279:
4275:
4270:
4266:
4262:
4258:
4253:
4248:
4245:(1): 117â28.
4244:
4240:
4236:
4229:
4227:
4223:
4218:
4214:
4209:
4204:
4200:
4196:
4192:
4188:
4184:
4177:
4175:
4171:
4166:
4162:
4157:
4152:
4148:
4144:
4141:(3): 729â33.
4140:
4136:
4132:
4125:
4123:
4119:
4114:
4110:
4105:
4100:
4095:
4090:
4086:
4082:
4078:
4071:
4069:
4065:
4060:
4056:
4052:
4048:
4043:
4038:
4035:(2): 425â40.
4034:
4030:
4026:
4019:
4016:
4011:
4007:
4002:
3997:
3993:
3989:
3985:
3981:
3977:
3970:
3967:
3962:
3958:
3954:
3950:
3946:
3942:
3938:
3934:
3927:
3924:
3919:
3915:
3910:
3905:
3901:
3897:
3894:(3): 235â52.
3893:
3889:
3885:
3878:
3875:
3870:
3866:
3861:
3856:
3852:
3848:
3845:(5): 329â39.
3844:
3840:
3836:
3829:
3826:
3821:
3817:
3813:
3809:
3805:
3801:
3797:
3790:
3787:
3782:
3778:
3773:
3768:
3764:
3760:
3756:
3749:
3746:
3741:
3737:
3732:
3727:
3722:
3717:
3713:
3709:
3705:
3701:
3697:
3690:
3687:
3682:
3678:
3673:
3668:
3664:
3660:
3656:
3652:
3648:
3641:
3638:
3633:
3629:
3624:
3619:
3615:
3611:
3607:
3600:
3597:
3592:
3588:
3583:
3578:
3573:
3568:
3564:
3560:
3556:
3549:
3547:
3543:
3538:
3534:
3530:
3526:
3522:
3518:
3514:
3507:
3504:
3499:
3495:
3491:
3487:
3482:
3477:
3473:
3469:
3465:
3458:
3456:
3452:
3447:
3443:
3439:
3435:
3431:
3427:
3420:
3417:
3412:
3408:
3403:
3398:
3394:
3390:
3386:
3382:
3378:
3371:
3368:
3361:
3358:
3353:
3349:
3345:
3341:
3336:
3331:
3327:
3323:
3319:
3312:
3309:
3304:
3300:
3296:
3292:
3287:
3282:
3278:
3274:
3270:
3263:
3260:
3255:
3251:
3247:
3243:
3239:
3238:2027.42/73065
3235:
3230:
3225:
3221:
3217:
3210:
3203:
3200:
3195:
3191:
3187:
3183:
3178:
3173:
3169:
3165:
3161:
3154:
3151:
3145:
3142:
3137:
3133:
3128:
3123:
3119:
3115:
3114:J. Biol. Chem
3111:
3104:
3101:
3096:
3092:
3088:
3084:
3080:
3076:
3072:
3068:
3061:
3058:
3047:on 2017-11-15
3043:
3039:
3035:
3031:
3027:
3022:
3017:
3013:
3009:
3002:
2995:
2993:
2989:
2984:
2980:
2976:
2972:
2968:
2964:
2960:
2956:
2948:
2945:
2940:
2936:
2932:
2928:
2924:
2920:
2916:
2912:
2905:
2902:
2897:
2893:
2888:
2883:
2879:
2875:
2872:(3): 331â44.
2871:
2867:
2863:
2856:
2853:
2848:
2844:
2839:
2834:
2830:
2826:
2822:
2818:
2814:
2807:
2804:
2799:
2795:
2790:
2785:
2781:
2777:
2773:
2769:
2765:
2758:
2755:
2750:
2746:
2741:
2736:
2732:
2728:
2727:J. Biol. Chem
2724:
2717:
2714:
2709:
2705:
2700:
2695:
2691:
2687:
2683:
2679:
2675:
2671:
2667:
2660:
2657:
2652:
2648:
2643:
2638:
2633:
2628:
2624:
2620:
2619:J. Biol. Chem
2616:
2609:
2606:
2601:
2597:
2592:
2587:
2583:
2579:
2575:
2571:
2567:
2560:
2557:
2552:
2548:
2543:
2538:
2534:
2530:
2526:
2522:
2518:
2511:
2508:
2503:
2499:
2495:
2491:
2486:
2481:
2478:(2): 315â29.
2477:
2473:
2469:
2461:
2458:
2453:
2449:
2445:
2441:
2437:
2433:
2429:
2425:
2418:
2415:
2410:
2406:
2402:
2398:
2394:
2390:
2386:
2382:
2375:
2373:
2369:
2364:
2360:
2355:
2350:
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2338:
2334:
2327:
2324:
2319:
2315:
2310:
2305:
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2295:
2291:
2287:
2286:J. Biol. Chem
2283:
2276:
2273:
2268:
2264:
2259:
2254:
2250:
2244:
2240:
2236:
2232:
2225:
2222:
2217:
2213:
2208:
2203:
2199:
2195:
2191:
2187:
2183:
2176:
2173:
2168:
2164:
2159:
2154:
2150:
2146:
2142:
2138:
2134:
2127:
2124:
2119:
2115:
2110:
2105:
2101:
2097:
2093:
2089:
2085:
2078:
2076:
2072:
2067:
2063:
2058:
2053:
2049:
2045:
2041:
2037:
2033:
2026:
2023:
2018:
2014:
2009:
2004:
1999:
1994:
1990:
1986:
1982:
1975:
1972:
1967:
1963:
1959:
1955:
1951:
1947:
1943:
1939:
1932:
1930:
1928:
1926:
1922:
1917:
1913:
1908:
1903:
1899:
1895:
1891:
1887:
1883:
1876:
1874:
1870:
1865:
1853:
1845:
1841:
1837:
1835:9780125400688
1831:
1827:
1823:
1819:
1812:
1809:
1804:
1800:
1795:
1790:
1786:
1782:
1779:(4): 979â83.
1778:
1774:
1770:
1763:
1760:
1755:
1751:
1746:
1741:
1737:
1733:
1730:(4): 535â46.
1729:
1725:
1721:
1714:
1711:
1706:
1702:
1697:
1692:
1688:
1684:
1680:
1676:
1672:
1665:
1662:
1657:
1653:
1648:
1643:
1639:
1635:
1631:
1627:
1623:
1616:
1613:
1608:
1604:
1599:
1594:
1590:
1586:
1582:
1578:
1574:
1567:
1564:
1559:
1555:
1550:
1545:
1541:
1537:
1533:
1529:
1525:
1521:
1517:
1509:
1506:
1501:
1497:
1492:
1487:
1483:
1479:
1476:(7): 781â91.
1475:
1471:
1467:
1460:
1458:
1456:
1454:
1450:
1445:
1441:
1436:
1431:
1427:
1423:
1419:
1415:
1411:
1404:
1401:
1396:
1392:
1387:
1382:
1377:
1372:
1368:
1364:
1361:(4): e93568.
1360:
1356:
1352:
1345:
1342:
1337:
1333:
1328:
1323:
1319:
1315:
1311:
1307:
1303:
1296:
1293:
1288:
1284:
1279:
1274:
1270:
1266:
1263:(1): 113â26.
1262:
1258:
1254:
1247:
1244:
1239:
1235:
1230:
1225:
1220:
1215:
1211:
1207:
1206:Int J Mol Sci
1203:
1196:
1193:
1186:
1182:
1179:
1177:
1174:
1172:
1169:
1167:
1164:
1162:
1159:
1158:
1154:
1148:
1144:
1140:
1136:
1133:
1130:
1127:
1125:
1122:
1121:
1117:
1114:
1111:
1109:
1106:
1105:
1101:
1099:
1095:
1091:
1088:
1086:
1083:
1080:
1076:
1075:
1071:
1069:
1066:
1064:
1061:
1058:
1055:
1052:
1050:
1048:
1047:S. cerevisiae
1043:) homolog 1,
1042:
1038:
1034:
1030:
1029:
1025:
1023:
1020:
1017:
1014:
1011:
1010:
1006:
1003:
1000:
996:
993:
990:
988:
984:
980:
976:
972:
969:
968:
964:
961:
958:
955:
952:
948:
945:
944:
940:
938:
934:
931:
928:
925:
924:
920:
917:
914:
912:
909:
908:
904:
902:
898:
895:
893:
890:
889:
885:
882:
879:
875:
873:
870:
869:
865:
862:
860:
857:
855:
852:
851:
847:
845:
842:
840:
837:
835:
832:
831:
827:
825:
821:
817:
813:
809:
807:
804:
802:
799:
798:
794:
791:
788:
786:
783:
780:
777:
776:
762:
759:
757:
753:
749:
742:
740:
739:DNA synthesis
735:
731:
727:
719:
717:
715:
711:
707:
703:
699:
695:
690:
685:
683:
679:
675:
671:
662:
660:
658:
654:
650:
646:
642:
638:
634:
630:
622:
614:
612:
609:
607:
604:
603:
599:
596:
592:
588:
585:
583:
580:
579:
575:
573:
570:
568:
565:
564:
560:
558:
554:
550:
546:
543:
541:
538:
537:
533:
530:mutations in
529:
527:
523:
519:
515:
512:
510:
507:
506:
502:
500:
497:
494:
493:
489:
485:
483:
479:
476:
474:
471:
470:
466:
464:
461:
459:
456:
455:
451:
449:
446:
444:
441:
440:
437:
433:
429:
427:
424:
421:
418:
417:
413:
409:
405:
401:
399:
396:
393:
390:
389:
385:
381:
377:
373:
371:
368:
365:
362:
361:
357:
355:
351:
347:
344:
341:
338:
337:
333:
328:
326:
322:
318:
314:
311:
308:
305:
304:
300:
296:
292:
287:
283:
280:
276:
273:
270:
267:
266:
262:
258:
254:
252:
248:
245:
243:
240:
239:
235:
233:
230:
228:
225:
224:
219:
217:
214:
212:
209:
208:
204:
201:
198:
197:
193:
187:
185:
177:
173:
170:
168:
165:
163:
160:
158:
155:
152:
149:
147:
144:
142:
139:
137:
134:
132:
129:
128:
124:
122:
120:
116:
112:
108:
104:
100:
96:
95:
86:
84:
82:
78:
77:
72:
68:
66:
62:
51:
45:
44:Endocrinology
42:
40:
36:
31:
19:
5642:Nasal glioma
5632:Dermoid cyst
5601:
5595:
5584:
5583:
5568:Mastocytosis
5555:
5549:EEM syndrome
5541:
5470:
5426:
5412:
5291:
5267:
5238:
4799:skin disease
4629:
4571:
4567:
4557:
4522:
4518:
4508:
4473:
4469:
4459:
4434:
4430:
4424:
4397:
4393:
4383:
4346:
4342:
4297:(1): 14â22.
4294:
4290:
4242:
4238:
4190:
4186:
4138:
4134:
4084:
4080:
4032:
4028:
4018:
3983:
3979:
3969:
3936:
3932:
3926:
3891:
3887:
3877:
3842:
3838:
3828:
3803:
3799:
3789:
3762:
3758:
3748:
3703:
3699:
3689:
3654:
3650:
3640:
3613:
3609:
3599:
3562:
3558:
3520:
3516:
3506:
3471:
3467:
3429:
3425:
3419:
3384:
3380:
3370:
3360:
3325:
3321:
3311:
3279:(2): 55â65.
3276:
3272:
3262:
3222:(2): 47â51.
3219:
3215:
3202:
3167:
3163:
3153:
3144:
3117:
3113:
3103:
3070:
3066:
3060:
3049:. Retrieved
3042:the original
3011:
3007:
2961:(7): 780â5.
2958:
2954:
2947:
2914:
2910:
2904:
2869:
2865:
2855:
2823:(3): 311â8.
2820:
2816:
2806:
2771:
2767:
2757:
2730:
2726:
2716:
2673:
2669:
2659:
2622:
2618:
2608:
2573:
2569:
2559:
2524:
2520:
2510:
2475:
2471:
2460:
2427:
2423:
2417:
2384:
2380:
2336:
2326:
2289:
2285:
2275:
2230:
2224:
2189:
2185:
2175:
2140:
2136:
2126:
2091:
2087:
2039:
2035:
2025:
1988:
1984:
1974:
1941:
1937:
1892:(1): 62â78.
1889:
1886:J. Mol. Biol
1885:
1817:
1811:
1776:
1772:
1762:
1727:
1723:
1713:
1678:
1674:
1664:
1629:
1625:
1615:
1580:
1576:
1566:
1523:
1519:
1508:
1473:
1469:
1417:
1413:
1403:
1358:
1354:
1344:
1312:(5): 503â9.
1309:
1305:
1295:
1260:
1256:
1246:
1212:(11): 1840.
1209:
1205:
1195:
1135:Colon cancer
1096:paired with
1078:
1046:
1044:
1040:
1036:
1032:
997:repairs the
811:
745:
723:
686:
666:
626:
531:
431:
408:8-oxoguanine
380:8-oxoguanine
260:
205:Description
181:
114:
110:
92:
90:
80:
74:
69:
60:
58:
5805:Skin dimple
5414:desmoplakin
5406:ungrouped:
5293:Cathepsin C
5269:plakoglobin
4970:and related
4343:Front Genet
3610:J. Cell Sci
3328:(2): 67â9.
1018:XPV (POLH)
1005:skin cancer
999:transcribed
932:FANCA etc.
297:(without a
5875:Senescence
5855:DNA repair
5844:Categories
5235:syndromic
5158:Cutis laxa
5145:Connective
4795:integument
4791:Congenital
4568:Oncotarget
4239:Hum. Mutat
3980:Mutat. Res
3800:Mutat. Res
3517:Mutat. Res
3432:(1): 3â7.
3322:Aging Cell
3273:Aging Cell
3216:Aging Cell
3051:2009-09-29
2670:Nat Commun
2137:Chromosoma
1985:PLOS Genet
1187:References
1181:Senescence
748:DNA repair
746:Inherited
732:. When a
726:DNA repair
689:phenotypes
635:kills the
255:deficient
65:DNA repair
5825:Birthmark
5618:anomalies
5585:see also
5063:related:
4916:Ungrouped
4476:: 81â90.
3651:Mol Oncol
3016:CiteSeerX
2676:: 13785.
2387:: 30â35.
1862:ignored (
1852:cite book
1724:Mol. Cell
956:XPC, XPE
866:breast
839:NBS (NBN)
752:mutations
678:mortality
39:Specialty
5860:Mutation
5543:cadherin
5428:connexin
5366:punctate
5240:connexin
4598:26431160
4549:23545420
4500:23714463
4451:15865943
4416:18403632
4375:23450852
4321:19078925
4261:24130121
4217:24764756
4165:21388382
4113:22044607
4059:38251423
4051:12518367
4010:19622404
3961:36781050
3953:10986997
3918:19083132
3869:20934517
3820:15916783
3740:18971343
3681:19383352
3632:15367581
3591:22373003
3537:12427531
3498:24698475
3490:21778326
3446:25238946
3411:17379580
3352:26925937
3344:15038820
3303:26832020
3295:15038819
3254:41182844
3246:15038817
3194:17615809
3186:17889645
3136:11756455
3087:12610296
3038:19594328
2983:11798376
2975:15980864
2955:Nat. Med
2939:29498397
2931:25555679
2896:20075015
2847:21389352
2798:22753033
2749:17611195
2708:27922005
2651:25122754
2600:12242278
2551:27225932
2502:18517518
2494:16439206
2444:26383140
2409:28321025
2401:27287744
2363:25843235
2318:24753253
2267:27147057
2216:17875923
2167:27136939
2118:17928034
2066:21730288
2017:23637614
1966:25146054
1958:23562424
1916:26616585
1844:11554293
1754:26833090
1705:14993263
1656:21571596
1607:22953029
1583:: 7219.
1558:27556946
1500:21612988
1444:20193758
1395:24740260
1355:PLOS ONE
1336:15105825
1306:EMBO Rep
1287:18371340
1238:27827925
1155:See also
1102:colon
1098:8-oxo-dG
935:HRR and
878:helicase
767:Protein
734:mutation
708:such as
670:diabetes
606:ZMPSTE24
488:progeria
227:DNA-PKcs
178:Examples
151:Progeria
5625:Midline
5210:diffuse
5141:Elastic
4636:D049914
4589:4741436
4540:3683898
4491:5889618
4366:3584444
4312:3693757
4269:2854418
4208:3983582
4156:3082610
4104:3221642
4001:2714807
3909:2713741
3860:3040982
3781:5770175
3772:1706430
3731:2579351
3708:Bibcode
3672:5527773
3582:3314554
3468:FASEB J
3402:2989184
3365:Review.
3067:Science
2887:2827637
2838:3091524
2789:3458577
2699:5150655
2678:Bibcode
2642:4175362
2542:4884211
2452:3195442
2354:4457563
2309:4047379
2258:5044759
2207:2169178
2158:5371645
2109:2692937
2057:3165551
2008:3630102
1907:4738086
1803:9927729
1745:4761302
1647:3234290
1598:3417667
1549:5161687
1528:Bibcode
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