919:
mechanism. The mechanism for hydrolysis is now thought to proceed as such: the enzyme is activated by a magnesium ion binding to binding site I, containing three water molecules, and stabilized by the negative charges on the carboxylates of Glu70 and Asp90, and the carbonyl of Ile92. Another magnesium ion then cooperatively binds to binding site 2, which has of carboxylates of Asp90, Asp93, Asp220, and three water molecules, one of which is shared by binding site 1. Then, a third magnesium weakly and non-cooperatively to the third binding site, which has 5 water molecules and residue Glu70. After all three magnesium ions have bound, the inositol monophosphatase can bind, the negatively charge phosphate group stabilized by the three positively charged magnesium ions. Finally an activated water molecule acts a nucleophile and hydrolyzes the substrate, giving inositol and inorganic phosphate.
987:. Diacylglycerol acts as a second messenger, activating several protein kinases and produces extended downstream signaling. Inositol triphosphate is also a second messenger which activates receptors on the endoplasmic reticulum to release calcium ion stores into the cytoplasm, creating a complex signaling system that can be involved in modulating fertilization, proliferation, contraction, cell metabolism, vesicle and fluid secretion, and information processing in neuronal cells. Overall, diacylglycerol and inositol triphosphate signaling has implications for neuronal plasticity, impacting hippocampal long term potentiation, stress-induced cognitive impairment, and neuronal growth cone spreading. Furthermore, not only is PIP
416:
3997:
1078:-inositol levels. Furthermore, lithium also binds to inositol polyphosphate 1-phosphatase (IPP), an enzyme also present in the phosphoinositide pathway, and could lower inositol levels through this mechanism More research is required to fully explain the role that lithium and IMPase play in bipolar disorder patients.
42:
1081:
Despite the fact that lithium is effective in treating bipolar disorder, it is an extremely toxic metal and the toxic dose is only marginally greater than the therapeutic dose. A novel inhibitor of inositol monophosphatase that is less toxic could be a more desirable treatment for bipolar disorder.
918:
It was previously reported that the hydrolysis of inositol monophosphate was catalyzed by IMPase through a 2-magnesium ion mechanism. However a recent 1.4 A resolution crystal structure shows 3 magnesium ions coordinating in each active binding site of the 2 dimers, supporting a 3-magnesium ion
1050:
acts according to the inositol depletion hypothesis: lithium produces its therapeutic effect by inhibiting IMPase and therefore decreasing levels of myo-inositol. Scientific support for this hypothesis exists but is limited; the complete role of lithium and inositol monophosphatase in treating
1058:
In support of the inositol depletion hypothesis, researchers have shown that lithium binds uncompetitively to purified bovine inositol monophosphatase at the site of one of the magnesium ions. Rodents administered lithium showed a decrease in inositol levels, in line with the hypothesis.
738:
family of enzymes. It is involved in the phosphophatidylinositol signaling pathway, which affects a wide array of cell functions, including but not limited to, cell growth, apoptosis, secretion, and information processing. Inhibition of inositol monophosphatase may be key in the action of
1772:
O'Donnell T, Rotzinger S, Nakashima TT, Hanstock CC, Ulrich M, Silverstone PH (October 2000). "Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in rat brain".
1102:
Arai R, Ito K, Ohnishi T, Ohba H, Akasaka R, Bessho Y, et al. (May 2007). "Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures".
1816:
Moore GJ, Bebchuk JM, Parrish JK, Faulk MW, Arfken CL, Strahl-Bevacqua J, et al. (December 1999). "Temporal dissociation between lithium-induced changes in frontal lobe myo-inositol and clinical response in manic-depressive illness".
927:
Inositol monophosphatase plays an important role in maintaining intracellular levels of myo-inositol, a molecule that forms the structural basis of several secondary messengers in eukaryotic cells. IMPase dephosphorylates the isomers of
1272:
Lu S, Huang W, Li X, Huang Z, Liu X, Chen Y, et al. (September 2012). "Insights into the role of magnesium triad in myo-inositol monophosphatase: metal mechanism, substrate binding, and lithium therapy".
1002:
to produce inorganic phosphate and myo-inositol, the precursor to PIP2. Because of IMPase's crucial role in this signaling pathway, it is a potential drug target for inhibition and modulation.
936:, mostly in the form of the stereoisomer, myo-inositol. Inositol monophosphatase is able to regulate inositol homeostasis because it lies at the convergence of two pathways that generate
2244:
Cole AG, Gani D (January 1995). "Active conformation of the inositol monophosphatase substrate, adenosine 2?-phosphate: role of the ribofuranosyl O-atoms in chelating a second Mg ion".
1034:-inositol 1 monophosphate by the enzyme glucose 6 phosphate cyclase. Inositol monophosphatase catalyzes the final step in which D-inositol 1 monophosphate is dephosphorylated to form
1702:
Saudek V, Vincendon P, Do QT, Atkinson RA, Sklenar V, Pelton PD, et al. (August 1996). "7Li nuclear-magnetic-resonance study of lithium binding to myo-inositolmonophosphatase".
783:
991:
a precursor to several signaling molecules, it can be phosphorylated at the 3’ position to become PIP3, which is involved in cell proliferation, apoptosis and cell movement.
1909:
Silverstone PH, McGrath BM (2009). "Lithium and valproate and their possible effects on themyo-inositol second messenger system in healthy volunteers and bipolar patients".
3634:
207:
2227:
Wilkie J, Cole AG, Gani D (January 1995). "3-Dimensional interactions between inositol monophosphatase and its substrates, inhibitors and metal ion cofactors".
602:
441:
276:
226:
1611:-Inositol 1-phosphate as intermediate in the biosynthesis of inositol from glucose 6-phosphate, and characteristics of two reactions in this biosynthesis"
1046:
Inositol monophosphatase has historically been believed to be a direct target of lithium, the primary treatment for bipolar disorder. It is thought that
906:
hollow active sites, each of which bind water and magnesium molecules. These binding sites appear to be conserved in other phosphodiesterases such as
2698:
3787:
3721:
2945:
4022:
3627:
4032:
4017:
2859:
1862:"Neurochemical alterations in adolescent bipolar depression: a proton magnetic resonance spectroscopy pilot study of the prefrontal cortex"
1063:, another mood-stabilizing drug given to bipolar disorder patients, has also been shown to mimic the effects of lithium on myo-inositol.
4042:
2960:
2954:
2755:
2505:
626:
465:
300:
2803:
2006:
3343:
2914:
2703:
3689:
3620:
614:
453:
288:
219:
3965:
3021:
2909:
607:
446:
281:
2740:
2693:
2271:
inositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis"
1420:
170:
146:
3499:
3252:
3193:
2442:"Evidence that inositol 1-phosphate in brain of lithium-treated rats results mainly from phosphatidylinositol metabolism"
1467:
Berridge MJ, Downes CP, Hanley MR (November 1989). "Neural and developmental actions of lithium: a unifying hypothesis".
967:
In this pathway, G-coupled protein receptors and tyrosine kinase receptors are activated, resulting in the activation of
3297:
2864:
2854:
2097:
Parthasarathy L, Vadnal RE, Parthasarathy R, Devi CS (1994). "Biochemical and molecular properties of lithium-sensitive
3257:
3149:
2774:
907:
3987:
2843:
2839:
2835:
2751:
2584:
587:
572:
434:
407:
261:
246:
3484:
3735:
3684:
3600:
3587:
3574:
3561:
3548:
3535:
3522:
3105:
3051:
3011:
2970:
2874:
2713:
2681:
2567:
2531:
3494:
164:
3448:
3391:
2759:
2608:
2522:
2436:
Cockcroft, S. (Ed.), Biology of
Phosphoinositides, Biology of Phosphoinositides, Oxford, 2000, p. 320-338.
667:
506:
341:
57:
1083:
151:
4027:
3396:
2628:
2498:
3184:
2823:
999:
929:
619:
768:
458:
293:
231:
3900:
3417:
3336:
3119:
3016:
2808:
2769:
2633:
2555:
984:
972:
523:
139:
3489:
74:
3302:
3137:
3132:
3065:
2725:
2550:
2187:
2049:
1373:
1324:
1047:
740:
684:
358:
3453:
3157:
3127:
2931:
2926:
2850:
2786:
2572:
1313:"High-resolution structure of myo-inositol monophosphatase, the putative target of lithium therapy"
1027:
956:
167:
69:
91:
3612:
3386:
3290:
3142:
2623:
2613:
2491:
2425:
2018:
1934:
1842:
1798:
1546:
1492:
1249:
1128:
4037:
3091:
3036:
3004:
2879:
2598:
2471:
2417:
2396:-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder"
2378:
2339:
2292:
2215:
2162:
2118:
2075:
2010:
1975:
1926:
1891:
1834:
1790:
1754:
1719:
1684:
1632:
1587:
1538:
1484:
1401:
1342:
1290:
1241:
1180:
1120:
735:
158:
1445:
Chung, Chang (1996). "A divergent synthesis of regio-isomers of myo-inositol monophosphate".
3649:
3432:
3427:
3401:
3329:
3167:
2747:
2652:
2647:
2603:
2461:
2453:
2407:
2368:
2329:
2321:
2282:
2249:
2232:
2205:
2195:
2174:
Pollack SJ, Atack JR, Knowles MR, McAllister G, Ragan CI, Baker R, et al. (June 1994).
2152:
2110:
2065:
2057:
2002:
1965:
1918:
1881:
1873:
1826:
1782:
1746:
1711:
1674:
1666:
1622:
1577:
1528:
1476:
1391:
1381:
1332:
1282:
1231:
1170:
1162:
1112:
1067:
748:
744:
679:
527:
518:
353:
688:
672:
511:
362:
346:
127:
3940:
3935:
3930:
3920:
3887:
3842:
3837:
3832:
3807:
3792:
3782:
3777:
3762:
3679:
3479:
3463:
3376:
3269:
3083:
2999:
2994:
2989:
2902:
2897:
2657:
2535:
2304:
Gee NS, Ragan CI, Watling KJ, Aspley S, Jackson RG, Reid GG, et al. (February 1988).
968:
806:
708:
547:
382:
1737:
Allison JH, Stewart MA (October 1971). "Reduced brain inositol in lithium-treated rats".
103:
2191:
2053:
2036:
Singh N, Halliday AC, Thomas JM, Kuznetsova OV, Baldwin R, Woon EC, et al. (2013).
1377:
1328:
62:
17:
4001:
3704:
3517:
3458:
3242:
3237:
3232:
2618:
2593:
2589:
2562:
2545:
2466:
2441:
2334:
2305:
2070:
2037:
1886:
1861:
1679:
1654:
1517:"Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder"
1311:
Gill R, Mohammed F, Badyal R, Coates L, Erskine P, Thompson D, et al. (May 2005).
1175:
1150:
980:
415:
202:
2390:
Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD (September 1997).
2373:
2352:
2287:
2262:
1970:
1953:
1786:
1627:
1606:
182:
4011:
3422:
3381:
2983:
2892:
2642:
2210:
2175:
2114:
1938:
1715:
1480:
1396:
1361:
879:
177:
2429:
2022:
1496:
1253:
1132:
317:
3654:
3371:
3110:
3041:
2764:
2685:
1846:
1802:
1550:
1582:
1565:
994:
In this pathway, IMPase is the common, final step in recycling IP3 to produce PIP
643:
482:
3858:
3714:
3675:
3595:
3530:
3366:
3285:
3056:
2950:
2813:
2779:
2717:
2483:
1424:
1220:"Lithium and bipolar mood disorder: the inositol-depletion hypothesis revisited"
903:
895:
887:
718:
557:
392:
186:
3996:
2180:
Proceedings of the
National Academy of Sciences of the United States of America
2176:"Mechanism of inositol monophosphatase, the putative target of lithium therapy"
1366:
Proceedings of the
National Academy of Sciences of the United States of America
1362:"Structure of inositol monophosphatase, the putative target of lithium therapy"
3645:
3262:
2157:
2140:
1922:
1337:
1312:
1166:
899:
891:
883:
650:
489:
324:
1670:
1386:
3569:
3543:
3175:
2974:
2887:
2514:
2200:
1830:
1060:
798:
2166:
2079:
1930:
1895:
1838:
1794:
1750:
1688:
1591:
1542:
1533:
1516:
1346:
1294:
1245:
1184:
1124:
2475:
2421:
2412:
2391:
2382:
2343:
2296:
2219:
2122:
2014:
1993:
Atack J (1997). "Inositol
Monophosphatase Inhibitors— Lithium Mimetics?".
1979:
1860:
Patel NC, Cecil KM, Strakowski SM, Adler CM, DelBello MP (December 2008).
1758:
1723:
1636:
1488:
1405:
1236:
1219:
3863:
3220:
3215:
3210:
3031:
2666:
2518:
2253:
2236:
1877:
952:
937:
933:
655:
494:
329:
2007:
10.1002/(sici)1098-1128(199703)17:2<215::aid-med3>3.0.co;2-2
115:
3227:
3205:
3200:
2818:
2132:
The
Pitfalls of Attempted Suicide: Hazards of Lithium Carbonate Therapy
2061:
1116:
134:
2457:
2325:
1286:
963:
Inositol monophosphatase in the phosphatidylinositol signaling pathway
3582:
3352:
3247:
3180:
3073:
2671:
2579:
638:
477:
312:
214:
110:
98:
86:
1151:"Molecular actions and clinical pharmacogenetics of lithium therapy"
886:
residues per subunit. Each dimer exists in 5 layers of alternating
3556:
3189:
2940:
2936:
802:
3950:
3945:
3925:
3915:
3910:
3905:
3827:
3822:
3817:
3812:
3802:
3797:
3772:
3767:
3757:
3752:
3747:
3742:
3709:
2921:
2798:
2791:
2735:
2730:
2353:"The effects of lithium ion and other agents on the activity of
631:
470:
305:
122:
3616:
3325:
2487:
41:
1570:
Biochimica et
Biophysica Acta (BBA) - Molecular Cell Research
1421:"Myo-inositol Monophosphatase, the Target of Lithium Therapy"
1317:
2440:
Ackermann KE, Gish BG, Honchar MP, Sherman WR (March 1987).
1515:
Schloesser RJ, Huang J, Klein PS, Manji HK (January 2008).
1086:
in order to reach the inositol monophosphatase in neurons.
3321:
1566:"Inositol trisphosphate and calcium signalling mechanisms"
1655:"Lithium: the pharmacodynamic actions of the amazing ion"
1070:
patients that had been administered lithium showed lower
1030:. In the first step, glucose 6-phosphate is converted to
772:
2246:
Journal of the
Chemical Society, Perkin Transactions 1
2229:
Journal of the
Chemical Society, Perkin Transactions 1
3985:
771:
420:
X-ray crystal structure of inositol monophosphatase 2
1954:"Properties of inositol polyphosphate 1-phosphatase"
3876:
3663:
3508:
3472:
3441:
3410:
3359:
3278:
3166:
3118:
3104:
3082:
3064:
3050:
3030:
2969:
2873:
2712:
2680:
2530:
1648:
1646:
910:(FBPase) and inositol polyphosphate 1-phosphatase.
714:
704:
699:
678:
666:
661:
649:
637:
625:
613:
601:
593:
583:
578:
571:
553:
543:
538:
517:
505:
500:
488:
476:
464:
452:
440:
430:
425:
406:
388:
378:
373:
352:
340:
335:
323:
311:
299:
287:
275:
267:
257:
252:
245:
225:
213:
201:
196:
176:
157:
145:
133:
121:
109:
97:
85:
80:
68:
56:
51:
34:
1866:Journal of Child and Adolescent Psychopharmacology
1510:
1508:
1506:
1074:-inositol levels, while others found no effect on
777:
2809:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
1462:
1460:
1360:Bone R, Springer JP, Atack JR (November 1992).
1066:However, some clinical studies have found that
979:), resulting in a membrane associated product,
1213:
1211:
1209:
1207:
3628:
3337:
2499:
2038:"A safe lithium mimetic for bipolar disorder"
857:-inositol-1(or 4)-phosphate phosphohydrolase,
8:
2310:-inositol monophosphatase from bovine brain"
1275:Journal of Chemical Information and Modeling
1306:
1304:
1200:
1198:
1196:
1194:
1149:Can A, Schulze TG, Gould TD (August 2014).
3880:
3667:
3635:
3621:
3613:
3344:
3330:
3322:
3115:
3061:
3047:
2506:
2492:
2484:
2357:-inositol-1-phosphatase from bovine brain"
1659:Therapeutic Advances in Psychopharmacology
1144:
1142:
1082:Such an inhibitor would need to cross the
944:The phosphatidylinositol signaling pathway
801:, specifically those acting on phosphoric
696:
535:
414:
370:
193:
2465:
2411:
2372:
2351:Hallcher LM, Sherman WR (November 1980).
2333:
2286:
2209:
2199:
2156:
2134:. London: The Medical Protection Society.
2069:
1969:
1885:
1678:
1626:
1581:
1532:
1395:
1385:
1336:
1267:
1265:
1263:
1235:
1174:
1055:-inositol levels is not well understood.
770:
2141:"Inhibitors of inositol monophosphatase"
1155:Pharmacology, Biochemistry, and Behavior
1018:There are at least 2 known steps in the
998:. IMPase does this by dephosphorylating
46:Inositol monophosphatase 2, dimer, Human
3992:
2699:Ubiquitin carboxy-terminal hydrolase L1
1094:
3722:Choline-phosphate cytidylyltransferase
1952:Inhorn RC, Majerus PW (October 1988).
1607:"Biochemical studies on inositol. IX.
568:
403:
242:
31:
3279:either deoxy- or ribo-
1605:Chen IW, Charalampous CF (May 1966).
816:. Other names in common use include:
797:This enzyme belongs to the family of
7:
2860:Protein serine/threonine phosphatase
2306:"The purification and properties of
814:-inositol-phosphate phosphohydrolase
2961:Cyclic nucleotide phosphodiesterase
2955:Clostridium perfringens alpha toxin
2756:Tartrate-resistant acid phosphatase
2361:The Journal of Biological Chemistry
2275:The Journal of Biological Chemistry
1958:The Journal of Biological Chemistry
1615:The Journal of Biological Chemistry
848:inositol monophosphate phosphatase,
778:{\displaystyle \rightleftharpoons }
3736:phosphatidylinositol glycan anchor
2804:Pyruvate dehydrogenase phosphatase
1911:International Review of Psychiatry
1819:The American Journal of Psychiatry
836:-inositol-1-phosphate phosphatase,
823:-inositol-1(or 4)-monophosphatase,
25:
2704:4-hydroxybenzoyl-CoA thioesterase
851:inositol-1(or 4)-monophosphatase,
3995:
1716:10.1111/j.1432-1033.1996.0288h.x
1704:European Journal of Biochemistry
1653:Brown KM, Tracy DK (June 2013).
1006:Inositol monophosphatase in the
973:phosphatidylinositol biphosphate
40:
35:inositol-1(or 4)-monophosphatase
3966:Phosphoric monoester hydrolases
3022:N-acetylglucosamine-6-sulfatase
2910:Sphingomyelin phosphodiesterase
983:, and a water-soluble product,
3971:Inositol-phosphate phosphatase
2831:Inositol-phosphate phosphatase
2694:Palmitoyl protein thioesterase
2139:Fauroux CM, Freeman S (1999).
902:per subunit. IMPase has three
863:-inositol monophosphatase, and
732:Inositol phosphate-phosphatase
1:
3194:RNA-induced silencing complex
2374:10.1016/S0021-9258(19)70391-3
2288:10.1016/S0021-9258(18)96102-8
1971:10.1016/S0021-9258(18)68256-0
1787:10.1016/s0006-8993(00)02797-9
1628:10.1016/S0021-9258(18)96606-8
1051:bipolar disorder or reducing
4023:Genes on human chromosome 18
3298:Serratia marcescens nuclease
2865:Dual-specificity phosphatase
2855:Protein tyrosine phosphatase
2145:Journal of Enzyme Inhibition
2115:10.1016/0024-3205(94)00835-3
2101:-inositol monophosphatase".
1583:10.1016/j.bbamcr.2008.10.005
1481:10.1016/0092-8674(89)90026-3
4033:Biology of bipolar disorder
4018:Genes on human chromosome 8
2775:Fructose 1,6-bisphosphatase
1447:Korean Journal of Med. Chem
1218:Harwood AJ (January 2005).
908:fructose 1,6-bisphosphatase
4059:
4043:Enzymes of known structure
2261:Eisenberg F (April 1967).
1995:Medicinal Research Reviews
573:Inositol monophosphatase 3
408:Inositol monophosphatase 2
247:Inositol monophosphatase 1
3961:
3896:
3883:
3853:
3730:
3700:
3685:Phosphatidate phosphatase
3670:
3500:Michaelis–Menten kinetics
3012:Galactosamine-6 sulfatase
2568:6-phosphogluconolactonase
2158:10.3109/14756369909036548
1923:10.1080/09540260902962214
1564:Berridge MJ (June 2009).
1338:10.1107/S0907444905004038
1167:10.1016/j.pbb.2014.02.004
695:
534:
413:
369:
192:
39:
3392:Diffusion-limited enzyme
2760:Purple acid phosphatases
1671:10.1177/2045125312471963
1387:10.1073/pnas.89.21.10031
869:-inositol-1-phosphatase.
842:-inositol 1-phosphatase,
754:The catalyzed reaction:
734:(EC 3.1.3.25) is of the
18:Inositol monophosphatase
2446:The Biochemical Journal
2314:The Biochemical Journal
2201:10.1073/pnas.91.13.5766
1831:10.1176/ajp.156.12.1902
1521:Neuropsychopharmacology
826:inositol 1-phosphatase,
761:-inositol phosphate + H
3185:Microprocessor complex
2824:Beta-propeller phytase
1751:10.1038/newbio233267a0
1534:10.1038/sj.npp.1301575
1000:inositol monophosphate
930:inositol monophosphate
779:
3901:Diacylglycerol kinase
3485:Eadie–Hofstee diagram
3418:Allosteric regulation
3120:Endodeoxyribonuclease
3017:Iduronate-2-sulfatase
2770:Glucose 6-phosphatase
2556:Butyrylcholinesterase
2413:10.1038/sj.mp.4000325
2042:Nature Communications
1237:10.1038/sj.mp.4001618
1042:Clinical significance
985:inositol triphosphate
845:inositol phosphatase,
788:-inositol + phosphate
780:
3495:Lineweaver–Burk plot
3303:Micrococcal nuclease
3138:Deoxyribonuclease IV
3133:Deoxyribonuclease II
3066:Exodeoxyribonuclease
2726:Alkaline phosphatase
2551:Acetylcholinesterase
2400:Molecular Psychiatry
2254:10.1039/P19950002685
2237:10.1039/P19950002709
1878:10.1089/cap.2007.151
1224:Molecular Psychiatry
769:
3158:UvrABC endonuclease
3128:Deoxyribonuclease I
2851:Protein phosphatase
2787:Protein phosphatase
2585:Bile salt-dependent
2573:PAF acetylhydrolase
2192:1994PNAS...91.5766P
2130:Bradley JJ (1988).
2054:2013NatCo...4.1332S
1378:1992PNAS...8910031B
1329:2005AcCrD..61..545G
1084:blood–brain barrier
1028:glucose 6-phosphate
971:, which hydrolyzes
957:glucose 6-phosphate
914:Catalytic mechanism
3454:Enzyme superfamily
3387:Enzyme promiscuity
3291:Mung bean nuclease
3150:Restriction enzyme
3143:Restriction enzyme
2062:10.1038/ncomms2320
1117:10.1002/prot.21299
775:
3983:
3982:
3979:
3978:
3872:
3871:
3610:
3609:
3319:
3318:
3315:
3314:
3311:
3310:
3100:
3099:
3092:Oligonucleotidase
3037:deoxyribonuclease
3005:Steroid sulfatase
2880:Phosphodiesterase
2609:Hormone-sensitive
2458:10.1042/bj2420517
2367:(22): 10896–901.
2326:10.1042/bj2490883
2266:
2248:(21): 2685–2694.
2231:(21): 2709–2727.
1610:
1287:10.1021/ci300172r
1033:
831:
736:phosphodiesterase
728:
727:
724:
723:
567:
566:
563:
562:
402:
401:
398:
397:
241:
240:
237:
236:
140:metabolic pathway
16:(Redirected from
4050:
4000:
3999:
3991:
3881:
3668:
3650:lipid metabolism
3637:
3630:
3623:
3614:
3490:Hanes–Woolf plot
3433:Enzyme activator
3428:Enzyme inhibitor
3402:Enzyme catalysis
3346:
3339:
3332:
3323:
3168:Endoribonuclease
3154:
3148:
3116:
3062:
3048:
2748:Acid phosphatase
2629:Monoacylglycerol
2539:ester hydrolases
2508:
2501:
2494:
2485:
2479:
2469:
2433:
2415:
2386:
2376:
2347:
2337:
2300:
2290:
2264:
2257:
2240:
2223:
2213:
2203:
2170:
2160:
2135:
2126:
2084:
2083:
2073:
2033:
2027:
2026:
1990:
1984:
1983:
1973:
1964:(28): 14559–65.
1949:
1943:
1942:
1906:
1900:
1899:
1889:
1857:
1851:
1850:
1813:
1807:
1806:
1769:
1763:
1762:
1734:
1728:
1727:
1699:
1693:
1692:
1682:
1650:
1641:
1640:
1630:
1608:
1602:
1596:
1595:
1585:
1561:
1555:
1554:
1536:
1512:
1501:
1500:
1464:
1455:
1454:
1442:
1436:
1435:
1433:
1432:
1423:. Archived from
1416:
1410:
1409:
1399:
1389:
1357:
1351:
1350:
1340:
1323:(Pt 5): 545–55.
1308:
1299:
1298:
1269:
1258:
1257:
1239:
1215:
1202:
1189:
1188:
1178:
1146:
1137:
1136:
1099:
1068:bipolar disorder
1031:
951:biosynthesis of
894:, totaling to 9
878:The enzyme is a
829:
784:
782:
781:
776:
749:manic depression
745:bipolar disorder
697:
569:
536:
418:
404:
371:
243:
194:
44:
32:
27:Class of enzymes
21:
4058:
4057:
4053:
4052:
4051:
4049:
4048:
4047:
4008:
4007:
4006:
3994:
3986:
3984:
3975:
3957:
3892:
3888:Phospholipase C
3868:
3849:
3726:
3696:
3680:Acyltransferase
3659:
3641:
3611:
3606:
3518:Oxidoreductases
3504:
3480:Enzyme kinetics
3468:
3464:List of enzymes
3437:
3406:
3377:Catalytic triad
3355:
3350:
3320:
3307:
3274:
3162:
3152:
3146:
3109:
3096:
3084:Exoribonuclease
3078:
3055:
3039:
3035:
3026:
3000:Arylsulfatase L
2995:Arylsulfatase B
2990:Arylsulfatase A
2965:
2878:
2869:
2708:
2676:
2538:
2526:
2512:
2482:
2439:
2392:"A novel human
2389:
2350:
2303:
2260:
2243:
2226:
2186:(13): 5766–70.
2173:
2138:
2129:
2109:(16): 1127–42.
2096:
2092:
2090:Further reading
2087:
2035:
2034:
2030:
1992:
1991:
1987:
1951:
1950:
1946:
1908:
1907:
1903:
1859:
1858:
1854:
1815:
1814:
1810:
1771:
1770:
1766:
1736:
1735:
1731:
1701:
1700:
1696:
1652:
1651:
1644:
1604:
1603:
1599:
1563:
1562:
1558:
1514:
1513:
1504:
1466:
1465:
1458:
1444:
1443:
1439:
1430:
1428:
1418:
1417:
1413:
1372:(21): 10031–5.
1359:
1358:
1354:
1310:
1309:
1302:
1281:(9): 2398–409.
1271:
1270:
1261:
1217:
1216:
1205:
1192:
1148:
1147:
1140:
1101:
1100:
1096:
1092:
1044:
1026:-inositol from
1016:
997:
990:
978:
969:phospholipase C
965:
925:
916:
882:comprising 277
876:
807:systematic name
795:
767:
766:
764:
747:, specifically
421:
47:
28:
23:
22:
15:
12:
11:
5:
4056:
4054:
4046:
4045:
4040:
4035:
4030:
4028:Mood disorders
4025:
4020:
4010:
4009:
4005:
4004:
3981:
3980:
3977:
3976:
3974:
3973:
3968:
3962:
3959:
3958:
3956:
3955:
3954:
3953:
3948:
3943:
3938:
3933:
3928:
3923:
3918:
3913:
3908:
3897:
3894:
3893:
3891:
3890:
3884:
3878:
3874:
3873:
3870:
3869:
3867:
3866:
3854:
3851:
3850:
3848:
3847:
3846:
3845:
3840:
3835:
3830:
3825:
3820:
3815:
3810:
3805:
3800:
3795:
3790:
3785:
3780:
3775:
3770:
3765:
3760:
3755:
3750:
3745:
3731:
3728:
3727:
3725:
3724:
3719:
3718:
3717:
3712:
3705:Choline kinase
3701:
3698:
3697:
3695:
3694:
3693:
3692:
3682:
3676:diacylglycerol
3671:
3665:
3661:
3660:
3658:
3657:
3652:
3642:
3640:
3639:
3632:
3625:
3617:
3608:
3607:
3605:
3604:
3591:
3578:
3565:
3552:
3539:
3526:
3512:
3510:
3506:
3505:
3503:
3502:
3497:
3492:
3487:
3482:
3476:
3474:
3470:
3469:
3467:
3466:
3461:
3456:
3451:
3445:
3443:
3442:Classification
3439:
3438:
3436:
3435:
3430:
3425:
3420:
3414:
3412:
3408:
3407:
3405:
3404:
3399:
3394:
3389:
3384:
3379:
3374:
3369:
3363:
3361:
3357:
3356:
3351:
3349:
3348:
3341:
3334:
3326:
3317:
3316:
3313:
3312:
3309:
3308:
3306:
3305:
3300:
3295:
3294:
3293:
3282:
3280:
3276:
3275:
3273:
3272:
3267:
3266:
3265:
3260:
3255:
3250:
3240:
3235:
3230:
3225:
3224:
3223:
3218:
3213:
3208:
3198:
3197:
3196:
3187:
3172:
3170:
3164:
3163:
3161:
3160:
3155:
3140:
3135:
3130:
3124:
3122:
3113:
3102:
3101:
3098:
3097:
3095:
3094:
3088:
3086:
3080:
3079:
3077:
3076:
3070:
3068:
3059:
3045:
3028:
3027:
3025:
3024:
3019:
3014:
3009:
3008:
3007:
3002:
2997:
2992:
2979:
2977:
2967:
2966:
2964:
2963:
2958:
2948:
2943:
2934:
2929:
2924:
2919:
2918:
2917:
2907:
2906:
2905:
2900:
2890:
2884:
2882:
2871:
2870:
2868:
2867:
2862:
2857:
2848:
2847:
2846:
2828:
2827:
2826:
2816:
2811:
2806:
2801:
2796:
2795:
2794:
2784:
2783:
2782:
2772:
2767:
2762:
2745:
2744:
2743:
2738:
2733:
2722:
2720:
2710:
2709:
2707:
2706:
2701:
2696:
2690:
2688:
2678:
2677:
2675:
2674:
2669:
2663:
2662:
2661:
2660:
2655:
2650:
2639:
2638:
2637:
2636:
2634:Diacylglycerol
2631:
2626:
2621:
2616:
2611:
2606:
2601:
2596:
2587:
2576:
2575:
2570:
2565:
2563:Pectinesterase
2560:
2559:
2558:
2553:
2546:Cholinesterase
2542:
2540:
2528:
2527:
2513:
2511:
2510:
2503:
2496:
2488:
2481:
2480:
2437:
2434:
2387:
2348:
2301:
2281:(7): 1375–82.
2258:
2241:
2224:
2171:
2136:
2127:
2093:
2091:
2088:
2086:
2085:
2028:
2001:(2): 215–224.
1985:
1944:
1901:
1852:
1825:(12): 1902–8.
1808:
1781:(1–2): 84–91.
1775:Brain Research
1764:
1729:
1694:
1642:
1621:(10): 2194–9.
1597:
1556:
1502:
1456:
1437:
1411:
1352:
1300:
1259:
1203:
1190:
1138:
1093:
1091:
1088:
1043:
1040:
1015:
1004:
995:
988:
981:diacylglycerol
976:
964:
961:
960:
959:
945:
924:
921:
915:
912:
875:
872:
871:
870:
864:
858:
852:
849:
846:
843:
837:
827:
824:
794:
791:
790:
789:
774:
762:
726:
725:
722:
721:
716:
712:
711:
706:
702:
701:
693:
692:
682:
676:
675:
670:
664:
663:
659:
658:
653:
647:
646:
641:
635:
634:
629:
623:
622:
617:
611:
610:
605:
599:
598:
595:
591:
590:
585:
581:
580:
576:
575:
565:
564:
561:
560:
555:
551:
550:
545:
541:
540:
532:
531:
521:
515:
514:
509:
503:
502:
498:
497:
492:
486:
485:
480:
474:
473:
468:
462:
461:
456:
450:
449:
444:
438:
437:
432:
428:
427:
423:
422:
419:
411:
410:
400:
399:
396:
395:
390:
386:
385:
380:
376:
375:
367:
366:
356:
350:
349:
344:
338:
337:
333:
332:
327:
321:
320:
315:
309:
308:
303:
297:
296:
291:
285:
284:
279:
273:
272:
269:
265:
264:
259:
255:
254:
250:
249:
239:
238:
235:
234:
229:
223:
222:
217:
211:
210:
205:
199:
198:
190:
189:
180:
174:
173:
162:
155:
154:
149:
143:
142:
137:
131:
130:
125:
119:
118:
113:
107:
106:
101:
95:
94:
89:
83:
82:
78:
77:
72:
66:
65:
60:
54:
53:
49:
48:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4055:
4044:
4041:
4039:
4036:
4034:
4031:
4029:
4026:
4024:
4021:
4019:
4016:
4015:
4013:
4003:
3998:
3993:
3989:
3972:
3969:
3967:
3964:
3963:
3960:
3952:
3949:
3947:
3944:
3942:
3939:
3937:
3934:
3932:
3929:
3927:
3924:
3922:
3919:
3917:
3914:
3912:
3909:
3907:
3904:
3903:
3902:
3899:
3898:
3895:
3889:
3886:
3885:
3882:
3879:
3875:
3865:
3861:
3860:
3856:
3855:
3852:
3844:
3841:
3839:
3836:
3834:
3831:
3829:
3826:
3824:
3821:
3819:
3816:
3814:
3811:
3809:
3806:
3804:
3801:
3799:
3796:
3794:
3791:
3789:
3786:
3784:
3781:
3779:
3776:
3774:
3771:
3769:
3766:
3764:
3761:
3759:
3756:
3754:
3751:
3749:
3746:
3744:
3741:
3740:
3739:
3738:biosynthesis:
3737:
3733:
3732:
3729:
3723:
3720:
3716:
3713:
3711:
3708:
3707:
3706:
3703:
3702:
3699:
3691:
3688:
3687:
3686:
3683:
3681:
3677:
3673:
3672:
3669:
3666:
3662:
3656:
3655:phospholipids
3653:
3651:
3647:
3644:
3643:
3638:
3633:
3631:
3626:
3624:
3619:
3618:
3615:
3602:
3598:
3597:
3592:
3589:
3585:
3584:
3579:
3576:
3572:
3571:
3566:
3563:
3559:
3558:
3553:
3550:
3546:
3545:
3540:
3537:
3533:
3532:
3527:
3524:
3520:
3519:
3514:
3513:
3511:
3507:
3501:
3498:
3496:
3493:
3491:
3488:
3486:
3483:
3481:
3478:
3477:
3475:
3471:
3465:
3462:
3460:
3459:Enzyme family
3457:
3455:
3452:
3450:
3447:
3446:
3444:
3440:
3434:
3431:
3429:
3426:
3424:
3423:Cooperativity
3421:
3419:
3416:
3415:
3413:
3409:
3403:
3400:
3398:
3395:
3393:
3390:
3388:
3385:
3383:
3382:Oxyanion hole
3380:
3378:
3375:
3373:
3370:
3368:
3365:
3364:
3362:
3358:
3354:
3347:
3342:
3340:
3335:
3333:
3328:
3327:
3324:
3304:
3301:
3299:
3296:
3292:
3289:
3288:
3287:
3284:
3283:
3281:
3277:
3271:
3268:
3264:
3261:
3259:
3256:
3254:
3251:
3249:
3246:
3245:
3244:
3241:
3239:
3236:
3234:
3231:
3229:
3226:
3222:
3219:
3217:
3214:
3212:
3209:
3207:
3204:
3203:
3202:
3199:
3195:
3191:
3188:
3186:
3182:
3179:
3178:
3177:
3174:
3173:
3171:
3169:
3165:
3159:
3156:
3151:
3144:
3141:
3139:
3136:
3134:
3131:
3129:
3126:
3125:
3123:
3121:
3117:
3114:
3112:
3107:
3103:
3093:
3090:
3089:
3087:
3085:
3081:
3075:
3072:
3071:
3069:
3067:
3063:
3060:
3058:
3053:
3049:
3046:
3043:
3038:
3033:
3029:
3023:
3020:
3018:
3015:
3013:
3010:
3006:
3003:
3001:
2998:
2996:
2993:
2991:
2988:
2987:
2986:
2985:
2984:arylsulfatase
2981:
2980:
2978:
2976:
2972:
2968:
2962:
2959:
2956:
2952:
2949:
2947:
2944:
2942:
2938:
2935:
2933:
2930:
2928:
2925:
2923:
2920:
2916:
2913:
2912:
2911:
2908:
2904:
2901:
2899:
2896:
2895:
2894:
2893:Phospholipase
2891:
2889:
2886:
2885:
2883:
2881:
2876:
2872:
2866:
2863:
2861:
2858:
2856:
2852:
2849:
2845:
2841:
2837:
2834:
2833:
2832:
2829:
2825:
2822:
2821:
2820:
2817:
2815:
2812:
2810:
2807:
2805:
2802:
2800:
2797:
2793:
2790:
2789:
2788:
2785:
2781:
2778:
2777:
2776:
2773:
2771:
2768:
2766:
2763:
2761:
2757:
2753:
2749:
2746:
2742:
2739:
2737:
2734:
2732:
2729:
2728:
2727:
2724:
2723:
2721:
2719:
2715:
2711:
2705:
2702:
2700:
2697:
2695:
2692:
2691:
2689:
2687:
2683:
2679:
2673:
2670:
2668:
2665:
2664:
2659:
2656:
2654:
2651:
2649:
2646:
2645:
2644:
2643:Phospholipase
2641:
2640:
2635:
2632:
2630:
2627:
2625:
2622:
2620:
2617:
2615:
2612:
2610:
2607:
2605:
2602:
2600:
2597:
2595:
2591:
2588:
2586:
2583:
2582:
2581:
2578:
2577:
2574:
2571:
2569:
2566:
2564:
2561:
2557:
2554:
2552:
2549:
2548:
2547:
2544:
2543:
2541:
2537:
2533:
2529:
2524:
2520:
2516:
2509:
2504:
2502:
2497:
2495:
2490:
2489:
2486:
2477:
2473:
2468:
2463:
2459:
2455:
2452:(2): 517–24.
2451:
2447:
2443:
2438:
2435:
2431:
2427:
2423:
2419:
2414:
2409:
2405:
2401:
2397:
2395:
2388:
2384:
2380:
2375:
2370:
2366:
2362:
2358:
2356:
2349:
2345:
2341:
2336:
2331:
2327:
2323:
2319:
2315:
2311:
2309:
2302:
2298:
2294:
2289:
2284:
2280:
2276:
2272:
2270:
2259:
2255:
2251:
2247:
2242:
2238:
2234:
2230:
2225:
2221:
2217:
2212:
2207:
2202:
2197:
2193:
2189:
2185:
2181:
2177:
2172:
2168:
2164:
2159:
2154:
2151:(2): 97–108.
2150:
2146:
2142:
2137:
2133:
2128:
2124:
2120:
2116:
2112:
2108:
2104:
2103:Life Sciences
2100:
2095:
2094:
2089:
2081:
2077:
2072:
2067:
2063:
2059:
2055:
2051:
2047:
2043:
2039:
2032:
2029:
2024:
2020:
2016:
2012:
2008:
2004:
2000:
1996:
1989:
1986:
1981:
1977:
1972:
1967:
1963:
1959:
1955:
1948:
1945:
1940:
1936:
1932:
1928:
1924:
1920:
1917:(4): 414–23.
1916:
1912:
1905:
1902:
1897:
1893:
1888:
1883:
1879:
1875:
1871:
1867:
1863:
1856:
1853:
1848:
1844:
1840:
1836:
1832:
1828:
1824:
1820:
1812:
1809:
1804:
1800:
1796:
1792:
1788:
1784:
1780:
1776:
1768:
1765:
1760:
1756:
1752:
1748:
1745:(43): 267–8.
1744:
1740:
1733:
1730:
1725:
1721:
1717:
1713:
1710:(1): 288–91.
1709:
1705:
1698:
1695:
1690:
1686:
1681:
1676:
1672:
1668:
1665:(3): 163–76.
1664:
1660:
1656:
1649:
1647:
1643:
1638:
1634:
1629:
1624:
1620:
1616:
1612:
1601:
1598:
1593:
1589:
1584:
1579:
1576:(6): 933–40.
1575:
1571:
1567:
1560:
1557:
1552:
1548:
1544:
1540:
1535:
1530:
1527:(1): 110–33.
1526:
1522:
1518:
1511:
1509:
1507:
1503:
1498:
1494:
1490:
1486:
1482:
1478:
1474:
1470:
1463:
1461:
1457:
1452:
1448:
1441:
1438:
1427:on 2013-06-04
1426:
1422:
1415:
1412:
1407:
1403:
1398:
1393:
1388:
1383:
1379:
1375:
1371:
1367:
1363:
1356:
1353:
1348:
1344:
1339:
1334:
1330:
1326:
1322:
1318:
1314:
1307:
1305:
1301:
1296:
1292:
1288:
1284:
1280:
1276:
1268:
1266:
1264:
1260:
1255:
1251:
1247:
1243:
1238:
1233:
1230:(1): 117–26.
1229:
1225:
1221:
1214:
1212:
1210:
1208:
1204:
1201:
1199:
1197:
1195:
1191:
1186:
1182:
1177:
1172:
1168:
1164:
1160:
1156:
1152:
1145:
1143:
1139:
1134:
1130:
1126:
1122:
1118:
1114:
1111:(3): 732–42.
1110:
1106:
1098:
1095:
1089:
1087:
1085:
1079:
1077:
1073:
1069:
1064:
1062:
1056:
1054:
1049:
1041:
1039:
1037:
1029:
1025:
1022:synthesis of
1021:
1013:
1010:synthesis of
1009:
1005:
1003:
1001:
992:
986:
982:
974:
970:
962:
958:
954:
950:
946:
943:
942:
941:
939:
935:
931:
922:
920:
913:
911:
909:
905:
901:
897:
893:
889:
885:
881:
873:
868:
865:
862:
859:
856:
853:
850:
847:
844:
841:
838:
835:
828:
825:
822:
819:
818:
817:
815:
813:
808:
804:
800:
792:
787:
760:
757:
756:
755:
752:
750:
746:
742:
737:
733:
720:
717:
713:
710:
707:
703:
698:
694:
691:
690:
686:
683:
681:
677:
674:
671:
669:
665:
660:
657:
654:
652:
648:
645:
642:
640:
636:
633:
630:
628:
624:
621:
618:
616:
612:
609:
606:
604:
600:
596:
592:
589:
586:
582:
577:
574:
570:
559:
556:
552:
549:
546:
542:
537:
533:
530:
529:
525:
522:
520:
516:
513:
510:
508:
504:
499:
496:
493:
491:
487:
484:
481:
479:
475:
472:
469:
467:
463:
460:
457:
455:
451:
448:
445:
443:
439:
436:
433:
429:
424:
417:
412:
409:
405:
394:
391:
387:
384:
381:
377:
372:
368:
365:
364:
360:
357:
355:
351:
348:
345:
343:
339:
334:
331:
328:
326:
322:
319:
316:
314:
310:
307:
304:
302:
298:
295:
292:
290:
286:
283:
280:
278:
274:
270:
266:
263:
260:
256:
251:
248:
244:
233:
230:
228:
224:
221:
218:
216:
212:
209:
206:
204:
200:
195:
191:
188:
184:
181:
179:
178:Gene Ontology
175:
172:
169:
166:
163:
160:
156:
153:
150:
148:
144:
141:
138:
136:
132:
129:
126:
124:
120:
117:
116:NiceZyme view
114:
112:
108:
105:
102:
100:
96:
93:
90:
88:
84:
79:
76:
73:
71:
67:
64:
61:
59:
55:
50:
43:
38:
33:
30:
19:
3970:
3857:
3734:
3596:Translocases
3593:
3580:
3567:
3554:
3541:
3531:Transferases
3528:
3515:
3372:Binding site
3153:}}
3147:{{
3111:Endonuclease
3042:ribonuclease
2982:
2830:
2765:Nucleotidase
2686:Thioesterase
2449:
2445:
2406:(5): 393–7.
2403:
2399:
2393:
2364:
2360:
2354:
2320:(3): 883–9.
2317:
2313:
2307:
2278:
2274:
2268:
2245:
2228:
2183:
2179:
2148:
2144:
2131:
2106:
2102:
2098:
2045:
2041:
2031:
1998:
1994:
1988:
1961:
1957:
1947:
1914:
1910:
1904:
1872:(6): 623–7.
1869:
1865:
1855:
1822:
1818:
1811:
1778:
1774:
1767:
1742:
1738:
1732:
1707:
1703:
1697:
1662:
1658:
1618:
1614:
1600:
1573:
1569:
1559:
1524:
1520:
1475:(3): 411–9.
1472:
1468:
1450:
1446:
1440:
1429:. Retrieved
1425:the original
1414:
1369:
1365:
1355:
1320:
1316:
1278:
1274:
1227:
1223:
1158:
1154:
1108:
1104:
1097:
1080:
1075:
1071:
1065:
1057:
1052:
1045:
1035:
1023:
1019:
1017:
1011:
1007:
993:
966:
948:
926:
917:
877:
866:
860:
854:
839:
833:
820:
811:
810:
796:
793:Nomenclature
785:
758:
753:
743:in treating
731:
729:
687:
594:Alt. symbols
526:
361:
318:NP_001138350
268:Alt. symbols
104:BRENDA entry
29:
3859:cardiolipin
3367:Active site
3286:Nuclease S1
3057:Exonuclease
2951:Lecithinase
2780:Calcineurin
2718:Phosphatase
2624:Lipoprotein
2614:Endothelial
1038:-inositol.
932:to produce
904:hydrophilic
805:bonds. The
730:The enzyme
709:Swiss-model
579:Identifiers
548:Swiss-model
426:Identifiers
383:Swiss-model
363:q21.1-q21.3
253:Identifiers
92:IntEnz view
75:37184-63-7
52:Identifiers
4012:Categories
3877:Catabolism
3646:Metabolism
3570:Isomerases
3544:Hydrolases
3411:Regulation
2599:Pancreatic
2536:Carboxylic
1453:: 162–165.
1431:2020-01-23
1090:References
884:amino acid
799:hydrolases
705:Structures
700:Search for
662:Other data
544:Structures
539:Search for
501:Other data
379:Structures
374:Search for
336:Other data
161:structures
128:KEGG entry
3664:Anabolism
3449:EC number
3176:RNase III
3034:(includes
2975:Sulfatase
2888:Autotaxin
2752:Prostatic
2604:Lysosomal
2519:esterases
2515:Hydrolase
1939:205645556
1419:Singh P.
1061:Valproate
1014:-inositol
896:α-helices
888:α-helices
874:Structure
803:monoester
773:⇌
668:EC number
644:NP_060283
603:NCBI gene
507:EC number
483:NP_055029
442:NCBI gene
342:EC number
277:NCBI gene
271:IMP; IMPA
81:Databases
4038:EC 3.1.3
3864:Tafazzin
3473:Kinetics
3397:Cofactor
3360:Activity
3270:RNase T1
3032:Nuclease
2667:Cutinase
2430:24336959
2167:10445037
2080:23299882
2048:: 1332.
2023:27534316
1931:20374155
1896:19108667
1839:10588403
1795:11032992
1689:24167688
1592:19010359
1543:17912251
1497:41816045
1347:15858264
1295:22889135
1254:20026448
1246:15558078
1185:24534415
1161:: 3–16.
1133:46602105
1125:17340635
1105:Proteins
953:inositol
938:inositol
934:inositol
923:Function
900:β-sheets
892:β-sheets
719:InterPro
673:3.1.3.25
558:InterPro
512:3.1.3.25
393:InterPro
347:3.1.3.25
232:proteins
220:articles
208:articles
165:RCSB PDB
63:3.1.3.25
4002:Biology
3583:Ligases
3353:Enzymes
3243:RNase E
3238:RNase Z
3233:RNase A
3228:RNase P
3201:RNase H
2819:Phytase
2619:Hepatic
2594:Lingual
2590:Gastric
2476:3036092
2467:1147736
2422:9322233
2383:6253491
2344:2833231
2335:1148789
2297:4290245
2220:8016062
2188:Bibcode
2123:8152337
2071:3605789
2050:Bibcode
2015:9057165
1980:2844776
1887:2935834
1847:5650139
1803:8823582
1759:5288124
1724:8925839
1680:3805456
1637:4287852
1551:2024963
1489:2553271
1406:1332026
1374:Bibcode
1325:Bibcode
1176:4220538
1048:lithium
1020:de novo
1008:de novo
949:de novo
741:lithium
715:Domains
651:UniProt
554:Domains
524:Chr. 18
490:UniProt
389:Domains
325:UniProt
187:QuickGO
152:profile
135:MetaCyc
70:CAS no.
3988:Portal
3557:Lyases
3181:Drosha
3106:3.1.21
3074:RecBCD
3052:3.1.11
2672:PETase
2580:Lipase
2474:
2464:
2428:
2420:
2381:
2342:
2332:
2295:
2218:
2208:
2165:
2121:
2078:
2068:
2021:
2013:
1978:
1937:
1929:
1894:
1884:
1845:
1837:
1801:
1793:
1757:
1739:Nature
1722:
1687:
1677:
1635:
1590:
1549:
1541:
1495:
1487:
1404:
1394:
1345:
1293:
1252:
1244:
1183:
1173:
1131:
1123:
685:Chr. 8
656:Q9NX62
639:RefSeq
632:614010
588:IMPAD1
584:Symbol
495:O14732
478:RefSeq
471:605922
431:Symbol
359:Chr. 8
330:P29218
313:RefSeq
306:602064
258:Symbol
215:PubMed
197:Search
183:AmiGO
171:PDBsum
111:ExPASy
99:BRENDA
87:IntEnz
58:EC no.
3509:Types
3190:Dicer
3145:;see
2971:3.1.6
2941:PDE4B
2937:PDE4A
2875:3.1.4
2844:IMPA3
2840:IMPA2
2836:IMPA1
2714:3.1.3
2682:3.1.2
2532:3.1.1
2426:S2CID
2211:44077
2019:S2CID
1935:S2CID
1843:S2CID
1799:S2CID
1547:S2CID
1493:S2CID
1397:50271
1250:S2CID
1129:S2CID
955:from
880:dimer
689:q12.1
680:Locus
620:26019
608:54928
597:IMPA3
528:p11.2
519:Locus
435:IMPA2
354:Locus
262:IMPA1
147:PRIAM
3951:DGKZ
3946:DGKQ
3941:DGKK
3936:DGKI
3931:DGKH
3926:DGKG
3921:DGKE
3916:DGKD
3911:DGKB
3906:DGKA
3843:PIGZ
3838:PIGY
3833:PIGX
3828:PIGW
3823:PIGV
3818:PIGU
3813:PIGT
3808:PIGS
3803:PIGQ
3798:PIGP
3793:PIGO
3788:PIGN
3783:PIGM
3778:PIGL
3773:PIGK
3768:PIGH
3763:PIGG
3758:PIGF
3753:PIGC
3748:PIGB
3743:PIGA
3715:CHKB
3710:CHKA
3601:list
3594:EC7
3588:list
3581:EC6
3575:list
3568:EC5
3562:list
3555:EC4
3549:list
3542:EC3
3536:list
3529:EC2
3523:list
3516:EC1
3108:-31:
3054:-16:
3040:and
2946:PDE5
2932:PDE3
2927:PDE2
2922:PDE1
2814:PTEN
2799:OCRL
2792:PP2A
2741:ALPP
2736:ALPL
2731:ALPI
2525:3.1)
2472:PMID
2418:PMID
2379:PMID
2340:PMID
2293:PMID
2216:PMID
2163:PMID
2119:PMID
2076:PMID
2011:PMID
1976:PMID
1927:PMID
1892:PMID
1835:PMID
1791:PMID
1755:PMID
1720:PMID
1685:PMID
1633:PMID
1588:PMID
1574:1793
1539:PMID
1485:PMID
1469:Cell
1402:PMID
1343:PMID
1291:PMID
1242:PMID
1181:PMID
1121:PMID
975:(PIP
947:The
898:and
890:and
627:OMIM
615:HGNC
466:OMIM
459:6051
454:HGNC
447:3613
301:OMIM
294:6050
289:HGNC
282:3612
227:NCBI
168:PDBe
123:KEGG
3674:to
3263:4/5
2462:PMC
2454:doi
2450:242
2408:doi
2394:myo
2369:doi
2365:255
2355:myo
2330:PMC
2322:doi
2318:249
2308:myo
2283:doi
2279:242
2269:myo
2250:doi
2233:doi
2206:PMC
2196:doi
2153:doi
2111:doi
2099:myo
2066:PMC
2058:doi
2003:doi
1966:doi
1962:263
1919:doi
1882:PMC
1874:doi
1827:doi
1823:156
1783:doi
1779:880
1747:doi
1743:233
1712:doi
1708:240
1675:PMC
1667:doi
1623:doi
1619:241
1578:doi
1529:doi
1477:doi
1392:PMC
1382:doi
1333:doi
1283:doi
1232:doi
1171:PMC
1163:doi
1159:123
1113:doi
1076:myo
1072:myo
1053:myo
1036:myo
1024:myo
1012:myo
867:myo
861:myo
855:myo
840:myo
834:myo
821:myo
812:myo
809:is
786:myo
759:myo
203:PMC
159:PDB
4014::
3862::
3690:2C
3678::
3648::
3221:2C
3216:2B
3211:2A
3192::
3183::
2973::
2853::
2842:,
2838:,
2754:)/
2716::
2684::
2653:A2
2648:A1
2534::
2523:EC
2517::
2470:.
2460:.
2448:.
2444:.
2424:.
2416:.
2402:.
2398:.
2377:.
2363:.
2359:.
2338:.
2328:.
2316:.
2312:.
2291:.
2277:.
2273:.
2214:.
2204:.
2194:.
2184:91
2182:.
2178:.
2161:.
2149:14
2147:.
2143:.
2117:.
2107:54
2105:.
2074:.
2064:.
2056:.
2044:.
2040:.
2017:.
2009:.
1999:17
1997:.
1974:.
1960:.
1956:.
1933:.
1925:.
1915:21
1913:.
1890:.
1880:.
1870:18
1868:.
1864:.
1841:.
1833:.
1821:.
1797:.
1789:.
1777:.
1753:.
1741:.
1718:.
1706:.
1683:.
1673:.
1661:.
1657:.
1645:^
1631:.
1617:.
1613:.
1586:.
1572:.
1568:.
1545:.
1537:.
1525:33
1523:.
1519:.
1505:^
1491:.
1483:.
1473:59
1471:.
1459:^
1449:.
1400:.
1390:.
1380:.
1370:89
1368:.
1364:.
1341:.
1331:.
1321:61
1319:.
1315:.
1303:^
1289:.
1279:52
1277:.
1262:^
1248:.
1240:.
1228:10
1226:.
1222:.
1206:^
1193:^
1179:.
1169:.
1157:.
1153:.
1141:^
1127:.
1119:.
1109:67
1107:.
940::
765:O
751:.
185:/
3990::
3636:e
3629:t
3622:v
3603:)
3599:(
3590:)
3586:(
3577:)
3573:(
3564:)
3560:(
3551:)
3547:(
3538:)
3534:(
3525:)
3521:(
3345:e
3338:t
3331:v
3258:3
3253:2
3248:1
3206:1
3044:)
2957:)
2953:(
2939:/
2915:1
2903:D
2898:C
2877::
2758:/
2750:(
2658:B
2592:/
2521:(
2507:e
2500:t
2493:v
2478:.
2456::
2432:.
2410::
2404:2
2385:.
2371::
2346:.
2324::
2299:.
2285::
2267:-
2265:D
2263:"
2256:.
2252::
2239:.
2235::
2222:.
2198::
2190::
2169:.
2155::
2125:.
2113::
2082:.
2060::
2052::
2046:4
2025:.
2005::
1982:.
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1639:.
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1609:D
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1032:D
996:2
989:2
977:2
832:-
830:L
763:2
20:)
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