317:
294:
191:
216:
575:
568:
323:
222:
40:
66:
1556:
Sozzani P, Hasan L, Séguélas MH, Caput D, Ferrara P, Pipy B, Cambon C (March 1998). "IL-13 induces tyrosine phosphorylation of phospholipase C gamma-1 following IRS-2 association in human monocytes: relationship with the inhibitory effect of IL-13 on ROI production".
2244:"Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2"
1676:"Erythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activation"
2209:"Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786"
1758:"An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events"
2357:"Mapping the RP2 locus for X-linked retinitis pigmentosa on proximal Xp: a genetically defined 5-cM critical region and exclusion of candidate genes by physical mapping"
2104:"Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phosphatidylinositol 3-kinase in primary adipocytes"
330:
229:
2174:"The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. Modulation by insulin growth factor-I (IGF) and enhanced IGF-I signaling"
953:
934:
152:
1403:
Ogihara T, Isobe T, Ichimura T, Taoka M, Funaki M, Sakoda H, Onishi Y, Inukai K, Anai M, Fukushima Y, Kikuchi M, Yazaki Y, Oka Y, Asano T (Oct 1997).
1989:"Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases"
1385:
2556:
1507:
Schubert M, Brazil DP, Burks DJ, Kushner JA, Ye J, Flint CL, Farhang-Fallah J, Dikkes P, Warot XM, Rio C, Corfas G, White MF (August 2003).
1367:
2513:"Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart"
1153:
316:
1298:
1160:
293:
2322:"Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling"
1635:"Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling"
1405:"14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain"
1444:
2390:
Izuhara K, Harada N (1997). "Interleukin-4 activates two distinct pathways of phosphatidylinositol-3 kinase in the same cells".
1354:
1333:
215:
190:
1350:
2279:"Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR"
63:
1329:
1250:
132:
1285:
2024:"4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice"
329:
228:
1756:
Hamer I, Foti M, Emkey R, Cordier-Bussat M, Philippe J, De Meyts P, Maeder C, Kahn CR, Carpentier JL (May 2002).
322:
221:
1258:
998:
140:
1245:
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of
979:
1954:"Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2"
1802:
White MF (1999). "The IRS-signalling system: a network of docking proteins that mediate insulin action".
204:
2478:"Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor"
2436:
2066:
1717:"Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling"
119:
1460:"Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes"
1136:
1089:
2139:"The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2"
2057:
Sun XJ, Wang LM, Zhang Y, et al. (1995). "Role of IRS-2 in insulin and cytokine signalling".
2308:
2090:
1905:
1827:
164:
1115:
1068:
1509:"Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation"
2534:
2499:
2464:
2407:
2378:
2343:
2300:
2265:
2230:
2195:
2160:
2125:
2082:
2045:
2010:
1975:
1940:
1897:
1862:
1819:
1779:
1738:
1697:
1656:
1615:
1594:"SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2"
1574:
1538:
1489:
1426:
1217:
112:
56:
2524:
2489:
2454:
2444:
2399:
2368:
2333:
2290:
2255:
2220:
2185:
2150:
2115:
2074:
2035:
2000:
1965:
1930:
1887:
1852:
1811:
1769:
1728:
1687:
1646:
1605:
1566:
1528:
1520:
1479:
1471:
1416:
574:
567:
409:
340:
284:
239:
17:
384:
160:
2440:
2070:
2420:
1533:
1524:
1508:
1262:
1484:
1459:
1276:
Mice lacking IRS2 have a diabetic phenotype as well as a 40% reduction in brain mass.
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
692:
687:
682:
677:
661:
656:
646:
641:
636:
631:
626:
621:
616:
39:
2550:
2459:
2424:
1876:"Defects of the insulin receptor substrate (IRS) system in human metabolic disorders"
1674:
Verdier F, Chrétien S, Billat C, Gisselbrecht S, Lacombe C, Mayeux P (October 1997).
1270:
603:
2312:
1831:
1265:
by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an
2094:
1909:
402:
181:
144:
1633:
Argetsinger LS, Norstedt G, Billestrup N, White MF, Carter-Su C (November 1996).
168:
1390:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1372:
National Center for
Biotechnology Information, U.S. National Library of Medicine
485:
2295:
2278:
1815:
1774:
1757:
301:
198:
148:
2529:
2512:
2494:
2477:
2338:
2321:
2260:
2243:
2040:
2023:
2005:
1988:
1733:
1716:
1692:
1675:
1651:
1634:
1421:
1404:
2225:
2208:
2190:
2173:
1857:
1840:
898:
651:
545:
423:
368:
355:
267:
254:
156:
2449:
2403:
2120:
2103:
1979:
1944:
1901:
1866:
1783:
1619:
1610:
1593:
1570:
1542:
1493:
1458:
Lin X, Taguchi A, Park S, Kushner JA, Li F, Li Y, White MF (October 2004).
2538:
2503:
2468:
2411:
2382:
2347:
2304:
2269:
2234:
2199:
2164:
2155:
2138:
2129:
2086:
2049:
2014:
1892:
1875:
1823:
1742:
1701:
1660:
1578:
1430:
1200:
1195:
759:
negative regulation of long-chain fatty acid import across plasma membrane
2373:
2356:
1254:
1184:
1043:
1024:
1970:
1953:
1935:
1918:
2207:
Sawka-Verhelle D, Tartare-Deckert S, White MF, Van
Obberghen E (1996).
1246:
1227:
1010:
965:
89:
85:
2078:
1475:
1304:
1168:
920:
1292:
1266:
2172:
Beitner-Johnson D, Blakesley VA, Shen-Orr Z, et al. (1996).
1919:"Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis"
883:
879:
1234:
136:
1592:
Rui L, Yuan M, Frantz D, Shoelson S, White MF (November 2002).
583:
2320:
Argetsinger LS, Norstedt G, Billestrup N, et al. (1997).
864:
positive regulation of phosphatidylinositol 3-kinase signaling
2425:"P110delta, a novel phosphoinositide 3-kinase in leukocytes"
1715:
Kim B, Cheng HL, Margolis B, Feldman EL (December 1998).
2476:
Sawka-Verhelle D, Baron V, Mothe I, et al. (1997).
2355:
Thiselton DL, Hampson RM, Nayudu M, et al. (1997).
392:
2511:
Algenstaedt P, Antonetti DA, Yaffe MB, Kahn CR (1997).
642:
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
1261:
and downstream effectors. The product of this gene is
869:
positive regulation of Ras protein signal transduction
2137:
Platanias LC, Uddin S, Yetter A, et al. (1996).
1987:
Johnston JA, Wang LM, Hanson EP, et al. (1996).
834:
phosphatidylinositol-3-phosphate biosynthetic process
769:
positive regulation of mesenchymal cell proliferation
557:
1874:
Sesti G, Federici M, Hribal ML, et al. (2001).
779:
positive regulation of cell population proliferation
719:
positive regulation of glycogen biosynthetic process
2022:Patti ME, Sun XJ, Bruening JC, et al. (1995).
1129:
1108:
1082:
1061:
839:
phosphatidylinositol phosphate biosynthetic process
1346:
1344:
1342:
1325:
1323:
1321:
2277:Zhang WR, Li PM, Oswald MA, Goldstein BJ (1996).
1257:by acting as a molecular adaptor between diverse
859:positive regulation of protein kinase B signaling
339:
238:
2102:Ridderstråle M, Degerman E, Tornqvist H (1995).
1445:"Entrez Gene: IRS2 insulin receptor substrate 2"
1212:For chemical compound with molecular formula IrS
734:positive regulation of glucose metabolic process
709:positive regulation of fatty acid beta-oxidation
799:negative regulation of B cell apoptotic process
27:Protein-coding gene in the species Homo sapiens
1952:Dearth RK, Cui X, Kim HJ, et al. (2007).
1351:GRCm38: Ensembl release 89: ENSMUSG00000038894
8:
2242:He W, Craparo A, Zhu Y, et al. (1996).
1330:GRCh38: Ensembl release 89: ENSG00000185950
774:positive regulation of B cell proliferation
894:
599:
380:
279:
176:
74:
2528:
2493:
2458:
2448:
2372:
2337:
2294:
2259:
2224:
2189:
2154:
2119:
2039:
2004:
1969:
1934:
1891:
1856:
1773:
1732:
1691:
1650:
1609:
1532:
1483:
1420:
1267:interleukin 4 receptor-associated kinase
854:interleukin-7-mediated signaling pathway
824:positive regulation of insulin secretion
647:1-phosphatidylinositol-3-kinase activity
1317:
809:phosphatidylinositol-mediated signaling
1841:"IL-4/IL-13 signaling beyond JAK/STAT"
1839:Jiang H, Harris MB, Rothman P (2000).
829:negative regulation of kinase activity
29:
814:cellular response to glucose stimulus
794:cellular response to insulin stimulus
754:regulation of lipid metabolic process
729:positive regulation of cell migration
714:positive regulation of glucose import
627:phosphatidylinositol 3-kinase binding
344:
305:
300:
243:
202:
197:
123:, IRS-2, insulin receptor substrate 2
7:
446:dorsal motor nucleus of vagus nerve
1525:10.1523/JNEUROSCI.23-18-07084.2003
1126:
1105:
1079:
1058:
1034:
1015:
989:
970:
944:
925:
844:insulin receptor signaling pathway
562:
480:
418:
397:
25:
1917:Gibson SL, Ma Z, Shaw LM (2007).
1230:that in humans is encoded by the
462:lateral nuclear group of thalamus
2423:, Kotani K, et al. (1997).
573:
566:
328:
321:
315:
292:
227:
220:
214:
189:
38:
662:protein domain specific binding
584:More reference expression data
546:More reference expression data
438:Region I of hippocampus proper
1:
2392:Biochem. Biophys. Res. Commun
1559:Biochem. Biophys. Res. Commun
804:cell population proliferation
313:
212:
2557:Genes on human chromosome 13
2429:Proc. Natl. Acad. Sci. U.S.A
1251:insulin-like growth factor 1
1224:Insulin receptor substrate 2
724:cellular response to peptide
18:Insulin receptor substrate 2
657:protein phosphatase binding
2573:
1211:
1154:Chr 13: 109.75 – 109.79 Mb
693:protein-containing complex
652:signal transducer activity
2296:10.1210/mend.10.5.8732688
1775:10.1007/s00125-002-0798-5
1386:"Mouse PubMed Reference:"
1368:"Human PubMed Reference:"
1259:receptor tyrosine kinases
1199:
1194:
1190:
1183:
1167:
1148:
1133:
1112:
1101:
1086:
1065:
1054:
1041:
1037:
1022:
1018:
1009:
996:
992:
977:
973:
964:
951:
947:
932:
928:
919:
904:
897:
893:
877:
789:glucose metabolic process
749:mammary gland development
602:
598:
581:
565:
556:
543:
492:
483:
450:mucosa of paranasal sinus
430:
421:
391:
383:
379:
362:
349:
312:
291:
282:
278:
261:
248:
211:
188:
179:
175:
130:
127:
117:
110:
105:
82:
77:
60:
55:
50:
46:
37:
32:
2530:10.1074/jbc.272.38.23696
2495:10.1074/jbc.272.26.16414
2339:10.1074/jbc.271.46.29415
2261:10.1074/jbc.271.20.11641
2041:10.1074/jbc.270.42.24670
2006:10.1074/jbc.270.48.28527
1845:J. Allergy Clin. Immunol
1734:10.1074/jbc.273.51.34543
1693:10.1074/jbc.272.42.26173
1652:10.1074/jbc.271.46.29415
1422:10.1074/jbc.272.40.25267
617:insulin receptor binding
504:Rostral migratory stream
2226:10.1074/jbc.271.11.5980
2191:10.1074/jbc.271.16.9287
1858:10.1067/mai.2000.107604
1816:10.1023/A:1006806722619
1284:IRS2 has been shown to
1161:Chr 8: 11.03 – 11.06 Mb
2450:10.1073/pnas.94.9.4330
2404:10.1006/bbrc.1996.1854
2121:10.1074/jbc.270.8.3471
1611:10.1074/jbc.C200444200
1571:10.1006/bbrc.1998.8314
637:protein kinase binding
622:14-3-3 protein binding
524:superior frontal gyrus
2156:10.1074/jbc.271.1.278
1893:10.1096/fj.01-0009rev
520:primary visual cortex
470:middle temporal gyrus
346:8 A1.1|8 5.35 cM
205:Chromosome 13 (human)
2374:10.1101/gr.6.11.1093
454:orbitofrontal cortex
307:Chromosome 8 (mouse)
78:List of PDB id codes
51:Available structures
2441:1997PNAS...94.4330V
2071:1995Natur.377..173S
1971:10.4161/cc.6.6.4035
1936:10.4161/cc.6.6.3987
1851:(6 Pt 1): 1063–70.
819:signal transduction
739:response to glucose
2419:Vanhaesebroeck B,
1804:Mol. Cell. Biochem
999:ENSMUSG00000038894
702:Biological process
671:Cellular component
610:Molecular function
2523:(38): 23696–702.
1218:Iridium disulfide
1210:
1209:
1206:
1205:
1179:
1178:
1144:
1143:
1123:
1122:
1097:
1096:
1076:
1075:
1050:
1049:
1031:
1030:
1005:
1004:
986:
985:
960:
959:
941:
940:
889:
888:
784:lipid homeostasis
764:brain development
594:
593:
590:
589:
552:
551:
539:
538:
532:cerebellar cortex
528:entorhinal cortex
477:
476:
466:entorhinal cortex
442:postcentral gyrus
375:
374:
274:
273:
101:
100:
97:
96:
61:Ortholog search:
16:(Redirected from
2564:
2542:
2532:
2507:
2497:
2488:(26): 16414–20.
2472:
2462:
2452:
2415:
2386:
2376:
2367:(11): 1093–102.
2351:
2341:
2332:(46): 29415–21.
2316:
2298:
2273:
2263:
2238:
2228:
2203:
2193:
2168:
2158:
2133:
2123:
2098:
2079:10.1038/377173a0
2053:
2043:
2018:
2008:
1999:(48): 28527–30.
1983:
1973:
1948:
1938:
1913:
1895:
1886:(12): 2099–111.
1870:
1860:
1835:
1788:
1787:
1777:
1753:
1747:
1746:
1736:
1727:(51): 34543–50.
1712:
1706:
1705:
1695:
1671:
1665:
1664:
1654:
1645:(46): 29415–21.
1630:
1624:
1623:
1613:
1589:
1583:
1582:
1553:
1547:
1546:
1536:
1504:
1498:
1497:
1487:
1476:10.1172/JCI22217
1455:
1449:
1448:
1441:
1435:
1434:
1424:
1415:(40): 25267–74.
1400:
1394:
1393:
1382:
1376:
1375:
1364:
1358:
1348:
1337:
1327:
1192:
1191:
1163:
1156:
1139:
1127:
1118:
1106:
1102:RefSeq (protein)
1092:
1080:
1071:
1059:
1035:
1016:
990:
971:
945:
926:
895:
600:
586:
577:
570:
563:
548:
516:genital tubercle
488:
486:Top expressed in
481:
458:Brodmann area 46
426:
424:Top expressed in
419:
398:
381:
371:
358:
347:
332:
325:
319:
308:
296:
280:
270:
257:
246:
231:
224:
218:
207:
193:
177:
171:
169:IRS2 - orthologs
122:
115:
92:
75:
69:
48:
47:
42:
30:
21:
2572:
2571:
2567:
2566:
2565:
2563:
2562:
2561:
2547:
2546:
2545:
2510:
2475:
2418:
2389:
2354:
2319:
2283:Mol. Endocrinol
2276:
2254:(20): 11641–5.
2241:
2206:
2184:(16): 9287–90.
2171:
2136:
2101:
2065:(6545): 173–7.
2056:
2034:(42): 24670–3.
2021:
1986:
1951:
1916:
1873:
1838:
1801:
1797:
1795:Further reading
1792:
1791:
1755:
1754:
1750:
1714:
1713:
1709:
1686:(42): 26173–8.
1673:
1672:
1668:
1632:
1631:
1627:
1604:(44): 42394–8.
1591:
1590:
1586:
1555:
1554:
1550:
1519:(18): 7084–92.
1506:
1505:
1501:
1464:J. Clin. Invest
1457:
1456:
1452:
1443:
1442:
1438:
1402:
1401:
1397:
1384:
1383:
1379:
1366:
1365:
1361:
1349:
1340:
1328:
1319:
1314:
1282:
1269:in response to
1243:
1221:
1215:
1201:View/Edit Mouse
1196:View/Edit Human
1159:
1152:
1149:Location (UCSC)
1135:
1114:
1088:
1067:
980:ENSG00000185950
873:
697:
688:plasma membrane
666:
632:protein binding
582:
572:
571:
544:
535:
530:
526:
522:
518:
514:
512:muscle of thigh
510:
506:
502:
498:
484:
473:
468:
464:
460:
456:
452:
448:
444:
440:
436:
422:
366:
353:
345:
335:
334:
333:
326:
306:
283:Gene location (
265:
252:
244:
234:
233:
232:
225:
203:
180:Gene location (
131:
118:
111:
84:
62:
28:
23:
22:
15:
12:
11:
5:
2570:
2568:
2560:
2559:
2549:
2548:
2544:
2543:
2508:
2473:
2416:
2387:
2352:
2317:
2274:
2239:
2219:(11): 5980–3.
2204:
2169:
2134:
2099:
2054:
2019:
1984:
1949:
1914:
1871:
1836:
1798:
1796:
1793:
1790:
1789:
1748:
1707:
1666:
1625:
1584:
1548:
1499:
1450:
1436:
1395:
1377:
1359:
1338:
1316:
1315:
1313:
1310:
1309:
1308:
1302:
1296:
1281:
1278:
1263:phosphorylated
1242:
1239:
1213:
1208:
1207:
1204:
1203:
1198:
1188:
1187:
1181:
1180:
1177:
1176:
1174:
1172:
1165:
1164:
1157:
1150:
1146:
1145:
1142:
1141:
1131:
1130:
1124:
1121:
1120:
1110:
1109:
1103:
1099:
1098:
1095:
1094:
1084:
1083:
1077:
1074:
1073:
1063:
1062:
1056:
1052:
1051:
1048:
1047:
1039:
1038:
1032:
1029:
1028:
1020:
1019:
1013:
1007:
1006:
1003:
1002:
994:
993:
987:
984:
983:
975:
974:
968:
962:
961:
958:
957:
949:
948:
942:
939:
938:
930:
929:
923:
917:
916:
911:
906:
902:
901:
891:
890:
887:
886:
875:
874:
872:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
705:
703:
699:
698:
696:
695:
690:
685:
680:
674:
672:
668:
667:
665:
664:
659:
654:
649:
644:
639:
634:
629:
624:
619:
613:
611:
607:
606:
596:
595:
592:
591:
588:
587:
579:
578:
560:
554:
553:
550:
549:
541:
540:
537:
536:
534:
533:
529:
525:
521:
517:
513:
509:
505:
501:
500:tail of embryo
497:
493:
490:
489:
478:
475:
474:
472:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
428:
427:
415:
414:
406:
395:
389:
388:
385:RNA expression
377:
376:
373:
372:
364:
360:
359:
351:
348:
343:
337:
336:
327:
320:
314:
310:
309:
304:
298:
297:
289:
288:
276:
275:
272:
271:
263:
259:
258:
250:
247:
242:
236:
235:
226:
219:
213:
209:
208:
201:
195:
194:
186:
185:
173:
172:
129:
125:
124:
116:
108:
107:
103:
102:
99:
98:
95:
94:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2569:
2558:
2555:
2554:
2552:
2540:
2536:
2531:
2526:
2522:
2518:
2517:J. Biol. Chem
2514:
2509:
2505:
2501:
2496:
2491:
2487:
2483:
2482:J. Biol. Chem
2479:
2474:
2470:
2466:
2461:
2456:
2451:
2446:
2442:
2438:
2435:(9): 4330–5.
2434:
2430:
2426:
2422:
2417:
2413:
2409:
2405:
2401:
2397:
2393:
2388:
2384:
2380:
2375:
2370:
2366:
2362:
2358:
2353:
2349:
2345:
2340:
2335:
2331:
2327:
2326:J. Biol. Chem
2323:
2318:
2314:
2310:
2306:
2302:
2297:
2292:
2289:(5): 575–84.
2288:
2284:
2280:
2275:
2271:
2267:
2262:
2257:
2253:
2249:
2248:J. Biol. Chem
2245:
2240:
2236:
2232:
2227:
2222:
2218:
2214:
2213:J. Biol. Chem
2210:
2205:
2201:
2197:
2192:
2187:
2183:
2179:
2178:J. Biol. Chem
2175:
2170:
2166:
2162:
2157:
2152:
2149:(1): 278–82.
2148:
2144:
2143:J. Biol. Chem
2140:
2135:
2131:
2127:
2122:
2117:
2114:(8): 3471–4.
2113:
2109:
2108:J. Biol. Chem
2105:
2100:
2096:
2092:
2088:
2084:
2080:
2076:
2072:
2068:
2064:
2060:
2055:
2051:
2047:
2042:
2037:
2033:
2029:
2028:J. Biol. Chem
2025:
2020:
2016:
2012:
2007:
2002:
1998:
1994:
1993:J. Biol. Chem
1990:
1985:
1981:
1977:
1972:
1967:
1964:(6): 705–13.
1963:
1959:
1955:
1950:
1946:
1942:
1937:
1932:
1928:
1924:
1920:
1915:
1911:
1907:
1903:
1899:
1894:
1889:
1885:
1881:
1877:
1872:
1868:
1864:
1859:
1854:
1850:
1846:
1842:
1837:
1833:
1829:
1825:
1821:
1817:
1813:
1810:(1–2): 3–11.
1809:
1805:
1800:
1799:
1794:
1785:
1781:
1776:
1771:
1768:(5): 657–67.
1767:
1763:
1759:
1752:
1749:
1744:
1740:
1735:
1730:
1726:
1722:
1721:J. Biol. Chem
1718:
1711:
1708:
1703:
1699:
1694:
1689:
1685:
1681:
1680:J. Biol. Chem
1677:
1670:
1667:
1662:
1658:
1653:
1648:
1644:
1640:
1639:J. Biol. Chem
1636:
1629:
1626:
1621:
1617:
1612:
1607:
1603:
1599:
1598:J. Biol. Chem
1595:
1588:
1585:
1580:
1576:
1572:
1568:
1565:(3): 665–70.
1564:
1560:
1552:
1549:
1544:
1540:
1535:
1530:
1526:
1522:
1518:
1514:
1510:
1503:
1500:
1495:
1491:
1486:
1481:
1477:
1473:
1470:(7): 908–16.
1469:
1465:
1461:
1454:
1451:
1446:
1440:
1437:
1432:
1428:
1423:
1418:
1414:
1410:
1406:
1399:
1396:
1391:
1387:
1381:
1378:
1373:
1369:
1363:
1360:
1356:
1352:
1347:
1345:
1343:
1339:
1335:
1331:
1326:
1324:
1322:
1318:
1311:
1306:
1303:
1300:
1297:
1294:
1291:
1290:
1289:
1287:
1279:
1277:
1274:
1272:
1268:
1264:
1260:
1256:
1252:
1248:
1240:
1238:
1236:
1233:
1229:
1225:
1219:
1202:
1197:
1193:
1189:
1186:
1182:
1175:
1173:
1170:
1166:
1162:
1158:
1155:
1151:
1147:
1140:
1138:
1132:
1128:
1125:
1119:
1117:
1111:
1107:
1104:
1100:
1093:
1091:
1085:
1081:
1078:
1072:
1070:
1064:
1060:
1057:
1055:RefSeq (mRNA)
1053:
1046:
1045:
1040:
1036:
1033:
1027:
1026:
1021:
1017:
1014:
1012:
1008:
1001:
1000:
995:
991:
988:
982:
981:
976:
972:
969:
967:
963:
956:
955:
950:
946:
943:
937:
936:
931:
927:
924:
922:
918:
915:
912:
910:
907:
903:
900:
896:
892:
885:
881:
876:
870:
867:
865:
862:
860:
857:
855:
852:
850:
849:axon guidance
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
706:
704:
701:
700:
694:
691:
689:
686:
684:
681:
679:
676:
675:
673:
670:
669:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
638:
635:
633:
630:
628:
625:
623:
620:
618:
615:
614:
612:
609:
608:
605:
604:Gene ontology
601:
597:
585:
580:
576:
569:
564:
561:
559:
555:
547:
542:
531:
527:
523:
519:
515:
511:
507:
503:
499:
495:
494:
491:
487:
482:
479:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
432:
429:
425:
420:
417:
416:
413:
411:
407:
405:
404:
400:
399:
396:
394:
390:
386:
382:
378:
370:
365:
361:
357:
352:
342:
338:
331:
324:
318:
311:
303:
299:
295:
290:
286:
281:
277:
269:
264:
260:
256:
251:
241:
237:
230:
223:
217:
210:
206:
200:
196:
192:
187:
183:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
126:
121:
114:
109:
104:
93:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
2520:
2516:
2485:
2481:
2432:
2428:
2398:(2): 624–9.
2395:
2391:
2364:
2360:
2329:
2325:
2286:
2282:
2251:
2247:
2216:
2212:
2181:
2177:
2146:
2142:
2111:
2107:
2062:
2058:
2031:
2027:
1996:
1992:
1961:
1957:
1929:(6): 631–7.
1926:
1922:
1883:
1879:
1848:
1844:
1807:
1803:
1765:
1762:Diabetologia
1761:
1751:
1724:
1720:
1710:
1683:
1679:
1669:
1642:
1638:
1628:
1601:
1597:
1587:
1562:
1558:
1551:
1516:
1512:
1502:
1467:
1463:
1453:
1439:
1412:
1408:
1398:
1389:
1380:
1371:
1362:
1283:
1280:Interactions
1275:
1253:, and other
1244:
1231:
1223:
1222:
1137:NP_001074681
1134:
1113:
1090:NM_001081212
1087:
1066:
1042:
1023:
997:
978:
952:
933:
913:
908:
744:MAPK cascade
408:
401:
266:109,786,583
253:109,752,695
128:External IDs
83:
1513:J. Neurosci
1409:J Biol Chem
1273:treatment.
496:skin of toe
367:11,058,458
354:11,034,681
106:Identifiers
2361:Genome Res
1958:Cell Cycle
1923:Cell Cycle
1357:, May 2017
1336:, May 2017
1312:References
412:(ortholog)
149:HomoloGene
2421:Welham MJ
1255:cytokines
1116:NP_003740
1069:NM_003749
899:Orthologs
678:cytoplasm
157:GeneCards
2551:Category
2313:42128485
1980:17374994
1945:17361103
1902:11641236
1867:10856136
1832:32623861
1784:12107746
1620:12228220
1543:12904469
1494:15467829
1353:–
1332:–
1286:interact
1241:Function
1185:Wikidata
878:Sources:
2539:9295312
2504:9195949
2469:9113989
2437:Bibcode
2412:8954948
2383:8938433
2348:8910607
2305:8732688
2270:8662806
2235:8626379
2200:8621590
2165:8550573
2130:7876077
2095:4336107
2087:7675087
2067:Bibcode
2050:7559579
2015:7499365
1910:6429338
1880:FASEB J
1824:9609109
1743:9852124
1702:9334184
1661:8910607
1579:9535722
1534:6740672
1431:9312143
1355:Ensembl
1334:Ensembl
1247:insulin
1228:protein
1011:UniProt
966:Ensembl
905:Species
884:QuickGO
683:cytosol
434:decidua
387:pattern
113:Aliases
2537:
2502:
2467:
2457:
2410:
2381:
2346:
2311:
2303:
2268:
2233:
2198:
2163:
2128:
2093:
2085:
2059:Nature
2048:
2013:
1978:
1943:
1908:
1900:
1865:
1830:
1822:
1782:
1741:
1700:
1659:
1618:
1577:
1541:
1531:
1492:
1485:518668
1482:
1429:
1305:PIK3R1
1288:with:
1216:, see
1171:search
1169:PubMed
1044:P81122
1025:Q9Y4H2
954:384783
921:Entrez
558:BioGPS
145:109334
137:600797
2460:20722
2309:S2CID
2091:S2CID
1906:S2CID
1828:S2CID
1301:, and
1299:SOCS1
1293:PLCG1
1226:is a
914:Mouse
909:Human
880:Amigo
508:molar
410:Mouse
403:Human
350:Start
285:Mouse
249:Start
245:13q34
182:Human
2535:PMID
2500:PMID
2465:PMID
2408:PMID
2379:PMID
2344:PMID
2301:PMID
2266:PMID
2231:PMID
2196:PMID
2161:PMID
2126:PMID
2083:PMID
2046:PMID
2011:PMID
1976:PMID
1941:PMID
1898:PMID
1863:PMID
1820:PMID
1780:PMID
1739:PMID
1698:PMID
1657:PMID
1616:PMID
1575:PMID
1539:PMID
1490:PMID
1427:PMID
1235:gene
1232:IRS2
935:8660
393:Bgee
341:Band
302:Chr.
240:Band
199:Chr.
161:IRS2
153:2778
133:OMIM
120:IRS2
90:3FQX
86:3FQW
67:RCSB
64:PDBe
33:IRS2
2525:doi
2521:272
2490:doi
2486:272
2455:PMC
2445:doi
2400:doi
2396:229
2369:doi
2334:doi
2330:271
2291:doi
2256:doi
2252:271
2221:doi
2217:271
2186:doi
2182:271
2151:doi
2147:271
2116:doi
2112:270
2075:doi
2063:377
2036:doi
2032:270
2001:doi
1997:270
1966:doi
1931:doi
1888:doi
1853:doi
1849:105
1812:doi
1808:182
1770:doi
1729:doi
1725:273
1688:doi
1684:272
1647:doi
1643:271
1606:doi
1602:277
1567:doi
1563:244
1529:PMC
1521:doi
1480:PMC
1472:doi
1468:114
1417:doi
1413:272
1271:IL4
363:End
262:End
165:OMA
141:MGI
57:PDB
2553::
2533:.
2519:.
2515:.
2498:.
2484:.
2480:.
2463:.
2453:.
2443:.
2433:94
2431:.
2427:.
2406:.
2394:.
2377:.
2363:.
2359:.
2342:.
2328:.
2324:.
2307:.
2299:.
2287:10
2285:.
2281:.
2264:.
2250:.
2246:.
2229:.
2215:.
2211:.
2194:.
2180:.
2176:.
2159:.
2145:.
2141:.
2124:.
2110:.
2106:.
2089:.
2081:.
2073:.
2061:.
2044:.
2030:.
2026:.
2009:.
1995:.
1991:.
1974:.
1960:.
1956:.
1939:.
1925:.
1921:.
1904:.
1896:.
1884:15
1882:.
1878:.
1861:.
1847:.
1843:.
1826:.
1818:.
1806:.
1778:.
1766:45
1764:.
1760:.
1737:.
1723:.
1719:.
1696:.
1682:.
1678:.
1655:.
1641:.
1637:.
1614:.
1600:.
1596:.
1573:.
1561:.
1537:.
1527:.
1517:23
1515:.
1511:.
1488:.
1478:.
1466:.
1462:.
1425:.
1411:.
1407:.
1388:.
1370:.
1341:^
1320:^
1249:,
1237:.
882:/
369:bp
356:bp
268:bp
255:bp
163:;
159::
155:;
151::
147:;
143::
139:;
135::
88:,
2541:.
2527::
2506:.
2492::
2471:.
2447::
2439::
2414:.
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2385:.
2371::
2365:6
2350:.
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2293::
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2237:.
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2202:.
2188::
2167:.
2153::
2132:.
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2097:.
2077::
2069::
2052:.
2038::
2017:.
2003::
1982:.
1968::
1962:6
1947:.
1933::
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1912:.
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1433:.
1419::
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1307:,
1295:,
1220:.
1214:2
287:)
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167::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
