612:
589:
51:
42:
2510:
2498:
1270:
Das K, Clark AD, Lewi PJ, Heeres J, De Jonge MR, Koymans LM, et al. (May 2004). "Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against
813:
In the EU, etravirine, in combination with a boosted protease inhibitor and other antiretrovirals, is indicated for the treatment of human-immunodeficiency-virus-type-1 (HIV-1) infection in antiretroviral-treatment-experienced people aged six years of age and older.
795:(FDA) approved its use for people with established resistance to other drugs, making it the 30th anti-HIV drug approved in the United States and the first to be approved in 2008. It was also approved for use in Canada in April 2008.
1895:
1387:
Alfedi G, Luffarelli R, Condò I, Pedini G, Mannucci L, Massaro DS, et al. (March 2019). "Drug repositioning screening identifies etravirine as a potential therapeutic for friedreich's ataxia".
228:
2079:
2084:
1017:
1180:
2540:
2030:
1502:
2469:
183:
1666:
739:
2036:
2550:
2094:
2014:
798:
Etravirine is licensed in the United States, Canada, Israel, Russia, Australia, New
Zealand, and the European Union, and is under regulatory review in Switzerland.
2099:
871:
776:
874:(NNRTI), designed to be active against HIV with mutations that confer resistance to the two most commonly prescribed first-generation NNRTIs, mutation K103N for
2047:
1448:
681:
81:
2069:
2053:
695:
2064:
2074:
1244:
2341:
1985:
1088:
1025:
1146:
1191:
1029:
1007:
Text was copied from this source which is copyright
European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
2440:
2331:
779:(NNRTI). Unlike agents in the class, resistance to other NNRTIs does not seem to confer resistance to etravirine. Etravirine is marketed by
1216:
2089:
1309:
Rajput L, Sanphui P, Desiraju GR (7 August 2013). "New Solid Forms of the Anti-HIV Drug
Etravirine: Salts, Cocrystals, and Solubility".
240:
1120:
2104:
723:
InChI=1S/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27)
1660:
1441:
715:
2114:
1998:
958:
2124:
2109:
1889:
1869:
1787:
1772:
1760:
831:
358:
213:
113:
2004:
1344:
Muresan-Pop M, Macavei S, Turza A, Borodi G (November 2021). "New solvates and a salt of the anti-HIV compound etravirine".
1426:
843:
1434:
1221:
792:
460:
2565:
2457:
911:
568:
132:
2488:
847:
842:
In 2009, the FDA prescribing information for etravirine was modified to include "postmarketing reports of cases of
2545:
1187:
992:
768:
2530:
2281:
2191:
2059:
2020:
902:, allowing for a more robust interaction between etravirine and the enzyme, even in the presence of mutations.
891:
2560:
2445:
2041:
780:
169:
1095:
1070:
607:
2570:
2119:
1248:
1158:
1043:
Stellbrink HJ (October 2007). "Antiviral drugs in the treatment of AIDS: what is in the pipeline ?".
292:
509:
2535:
2316:
2129:
2009:
1879:
1478:
895:
810:
for the treatment of HIV-1 infection in treatment-experienced patients aged two years of age and older.
2025:
1874:
1632:
899:
858:
reactions characterized by rash, constitutional findings, and sometimes organ dysfunction, including
788:
327:
584:
2134:
1993:
1865:
1783:
1582:
1461:
851:
375:
50:
529:
1412:
1369:
927:
827:
143:
882:. This potency appears to be related to etravirine's flexibility as a molecule. Etravirine is a
2422:
2417:
550:
2555:
2276:
1939:
1404:
1361:
1326:
1288:
1121:"Intelence receives marketing authorisation in the European Union for HIV combination therapy"
1052:
987:
540:
265:
252:
63:
2301:
1396:
1353:
1318:
1280:
1124:
1074:
887:
883:
855:
624:
449:
384:
284:
469:
2502:
2377:
2336:
1496:
302:
1022:
Guidelines for the Use of
Antiretroviral Agents in HIV-1-Infected Adults and Adolescents
918:. The structures of these and of a number of solvate and salt forms have been reported.
611:
588:
2514:
2451:
2227:
2209:
2172:
1457:
2524:
2217:
1967:
1802:
1688:
1373:
859:
600:
105:
1416:
41:
2271:
2261:
1842:
1832:
1650:
1607:
1602:
1597:
1559:
1539:
1469:
520:
409:
196:
191:
91:
2397:
2372:
2311:
2296:
2291:
1955:
1922:
1837:
1817:
1612:
1592:
1571:
1518:
1486:
99:
2402:
2382:
2367:
2362:
2326:
2321:
2235:
2180:
2150:
1962:
1945:
1917:
1857:
1847:
1822:
1807:
1797:
1746:
1741:
1729:
1713:
1703:
1683:
1645:
1555:
1543:
1535:
1357:
879:
784:
657:
440:
1330:
2412:
2392:
2387:
2357:
2286:
2266:
2199:
2155:
1912:
1827:
1812:
1735:
1708:
1698:
1693:
1640:
1617:
1530:
875:
823:
807:
340:
85:
1408:
1365:
1292:
1056:
33:
2407:
1792:
931:
420:
176:
127:
17:
429:
2475:
2306:
1852:
1622:
1154:
1089:"First New NNRTI in Nearly a Decade to Benefit Canadians with HIV/AIDS"
395:
319:
2509:
1400:
1322:
1284:
2256:
2251:
500:
315:
311:
489:
1566:
680:
671:
556:
307:
1525:
1513:
1094:(Press release). Janssen-Ortho Inc. 1 April 2008. Archived from
480:
271:
246:
1430:
259:
122:
1550:
1465:
775:. Etravirine is a human immunodeficiency virus type 1 (HIV-1)
772:
573:
2080:
Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide
222:
154:
2085:
Elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil
930:
application. Etravirine was shown to cause an increase in
2031:
Darunavir/cobicistat/emtricitabine/tenofovir alafenamide
235:
746:
1346:
2486:
953:
951:
949:
947:
2350:
2244:
2226:
2208:
2190:
2171:
2164:
2143:
1984:
1931:
1905:
1888:
1771:
1759:
1722:
1676:
1659:
1631:
1581:
1495:
1477:
669:
656:
623:
618:
599:
567:
539:
519:
499:
479:
459:
439:
419:
394:
374:
349:
339:
326:
301:
291:
283:
212:
207:
182:
168:
142:
112:
98:
80:
72:
62:
57:
703:N#Cc3cc(c(Oc1nc(nc(c1Br)N)Nc2ccc(C#N)cc2)c(c3)C)C
2037:Dolutegravir/emtricitabine/tenofovir alafenamide
982:
980:
408:
2541:Non-nucleoside reverse transcriptase inhibitors
2095:Emtricitabine/rilpivirine/tenofovir alafenamide
2015:Bictegravir/emtricitabine/tenofovir alafenamide
383:
2100:Emtricitabine/rilpivirine/tenofovir disoproxil
1586:(Integrase strand transfer inhibitors (INSTI))
1271:wild-type and drug-resistant HIV-1 variants".
1181:"Etravine: Summary of product characteristics"
872:non-nucleoside reverse transcriptase inhibitor
777:non-nucleoside reverse transcriptase inhibitor
366:4- pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile
2048:Dolutegravir/lamivudine/tenofovir alafenamide
1442:
8:
2070:Efavirenz/emtricitabine/tenofovir disoproxil
2054:Dolutegravir/lamivudine/tenofovir disoproxil
528:
131:
32:
2168:
2065:Doravirine/lamivudine/tenofovir disoproxil
1902:
1768:
1673:
1449:
1435:
1427:
610:
587:
448:
2075:Efavirenz/lamivudine/tenofovir disoproxil
468:
2551:Drugs developed by Johnson & Johnson
2342:Zinc finger protein transcription factor
822:People with rare hereditary problems of
27:Medication used for the treatment of HIV
2493:
1026:Department of Health and Human Services
943:
926:Etravine has been studied for use in a
720:
700:
583:
428:
363:
104:
601:
31:
1304:
1302:
1151:) granted accelerated approval in US"
549:
508:
90:
7:
1045:European Journal of Medical Research
555:
195:
2090:Emtricitabine/tenofovir alafenamide
488:
399:
2105:Emtricitabine/tenofovir disoproxil
1071:"FDA Approves HIV Drug Etravirine"
870:Etravirine is a second-generation
25:
1217:"FDA Medwatch Safety Information"
2508:
2496:
2478:. Formerly or rarely used agent.
2115:Lamivudine/nevirapine/zidovudine
1999:Abacavir/dolutegravir/lamivudine
1245:"Etravirine—Countdown to Launch"
644:
635:
49:
40:
2282:Epigallocatechin gallate (EGCG)
2125:Lamivudine/tenofovir disoproxil
2110:Lamivudine/nevirapine/stavudine
834:should not take this etravine.
832:glucose-galactose malabsorption
728:Key:PYGWGZALEOIKDF-UHFFFAOYSA-N
641:
2005:Abacavir/lamivudine/zidovudine
1273:Journal of Medicinal Chemistry
1247:. AIDSmeds.com. Archived from
959:"Intelence- etravirine tablet"
763:,), sold under the brand name
650:
629:
1:
1018:"Appendix A: Key to Acronyms"
910:Etravine forms as colourless
1222:Food and Drug Administration
914:crystals in space group Pna2
793:Food and Drug Administration
345:Faeces (93.7%), urine (1.2%)
1880:Tenofovir alafenamide (TAF)
1311:Crystal Growth & Design
1243:Evans D (15 January 2008).
1190:. p. 5. Archived from
2587:
1875:Tenofovir disoproxil (TDF)
848:toxic epidermal necrolysis
791:. In January 2008, the US
771:used for the treatment of
619:Chemical and physical data
2435:
1896:Discovery and development
1667:Discovery and development
1503:Discovery and development
1358:10.1107/S2053229621010482
1123:. Tibotec. Archived from
993:European Medicines Agency
894:that can bind the enzyme
806:In the US, etravirine is
769:antiretroviral medication
736:
711:
691:
354:
48:
39:
2192:Transcription inhibitors
2144:Pharmacokinetic boosters
2060:Dolutegravir/rilpivirine
2021:Cabotegravir/rilpivirine
1661:Protease Inhibitors (PI)
892:conformational isomerism
844:Stevens–Johnson syndrome
2476:initial regimen options
2042:Dolutegravir/lamivudine
1519:Enfuvirtide (ENF, T-20)
1497:Entry/fusion inhibitors
2317:Portmanteau inhibitors
2210:Translation inhibitors
2120:Lamivudine/raltegravir
1890:Non-nucleoside (NNRTI)
1848:Islatravir (EFdA, ISL)
826:intolerance, the Lapp
2332:Synergistic enhancers
2130:Lamivudine/zidovudine
2010:Atazanavir/cobicistat
1986:Combined formulations
1823:Zidovudine (AZT, ZDV)
1761:Reverse-transcriptase
1633:Maturation inhibitors
1147:"Etravirine (TMC125,
896:reverse transcriptase
789:Johnson & Johnson
2173:Uncoating inhibitors
2026:Darunavir/cobicistat
1866:Nucleotide analogues
1784:Nucleoside analogues
1583:Integrase inhibitors
1462:antiretroviral drugs
1127:on 28 September 2011
2165:Experimental agents
2135:Lopinavir/ritonavir
1994:Abacavir/lamivudine
1968:Elsulfavirine (ESV)
1803:Emtricitabine (FTC)
1689:Fosamprenavir (FPV)
866:Mechanism of action
852:erythema multiforme
255:(Prescription only)
231:(Prescription only)
36:
2566:Belgian inventions
2462:Never to phase III
1608:Elvitegravir (EVG)
1603:Dolutegravir (DTG)
1598:Cabotegravir (CAB)
1389:Movement Disorders
1352:(Pt 11): 698–706.
1251:on 19 January 2008
1101:on 2 November 2010
1077:. 18 January 2008.
1032:on 31 August 2012.
928:drug repositioning
886:(DAPY), a type of
828:lactase deficiency
2484:
2483:
2431:
2430:
2277:Diarylpyrimidines
1980:
1979:
1976:
1975:
1956:Rilpivirine (RPV)
1940:diarylpyrimidines
1923:Delavirdine (DLV)
1818:Zalcitabine (ddC)
1775:nucleotide (NRTI)
1755:
1754:
1613:Raltegravir (RAL)
1593:Bictegravir (BIC)
1572:Fostemsavir (FTR)
1487:Lenacapavir (LEN)
1479:Capsid inhibitors
1401:10.1002/mds.27604
1323:10.1021/cg4007058
1285:10.1021/jm030558s
1279:(10): 2550–2560.
1197:on 20 August 2016
1161:on 2 January 2010
754:
753:
682:Interactive image
569:CompTox Dashboard
275:
263:
250:
238:
226:
158:
125:
16:(Redirected from
2578:
2546:Aminopyrimidines
2513:
2512:
2501:
2500:
2499:
2492:
2302:Hydroxycarbamide
2169:
1963:Doravirine (DOR)
1951:Etravirine (ETR)
1946:Dapivirine (DPV)
1918:Nevirapine (NVP)
1903:
1808:Lamivudine (3TC)
1798:Didanosine (ddI)
1769:
1742:Tipranavir (TPV)
1730:Atazanavir (ATV)
1714:Saquinavir (SQV)
1704:Nelfinavir (NFV)
1684:Amprenavir (APV)
1674:
1556:Ibalizumab (IBA)
1451:
1444:
1437:
1428:
1421:
1420:
1384:
1378:
1377:
1341:
1335:
1334:
1317:(8): 3681–3690.
1306:
1297:
1296:
1267:
1261:
1260:
1258:
1256:
1240:
1234:
1233:
1231:
1229:
1213:
1207:
1206:
1204:
1202:
1196:
1185:
1177:
1171:
1170:
1168:
1166:
1157:. Archived from
1143:
1137:
1136:
1134:
1132:
1117:
1111:
1110:
1108:
1106:
1100:
1093:
1085:
1079:
1078:
1075:Associated Press
1067:
1061:
1060:
1040:
1034:
1033:
1028:. Archived from
1014:
1008:
1006:
1004:
1002:
997:. 28 August 2008
988:"Intelence EPAR"
984:
975:
974:
972:
970:
965:. 15 August 2023
955:
888:organic molecule
884:diarylpyrimidine
856:hypersensitivity
818:Contraindication
750:
749:
742:
684:
664:
652:
646:
643:
637:
631:
614:
603:
592:
591:
577:
575:
559:
553:
532:
512:
492:
472:
452:
432:
412:
402:
401:
387:
331:
273:
270:
261:
258:
248:
245:
237:
234:
224:
221:
199:
156:
153:
135:
124:
121:
108:
94:
53:
44:
37:
35:
21:
2586:
2585:
2581:
2580:
2579:
2577:
2576:
2575:
2531:CYP3A4 inducers
2521:
2520:
2519:
2507:
2497:
2495:
2487:
2485:
2480:
2479:
2467:
2452:Clinical trials
2427:
2378:Dexelvucitabine
2346:
2337:Tre recombinase
2240:
2222:
2204:
2200:Tat antagonists
2186:
2160:
2139:
1972:
1927:
1913:Efavirenz (EFV)
1892:
1884:
1813:Stavudine (d4T)
1774:
1762:
1751:
1736:Darunavir (DRV)
1718:
1709:Ritonavir (RTV)
1699:Lopinavir (LPV)
1694:Indinavir (IDV)
1663:
1655:
1627:
1585:
1577:
1531:Maraviroc (MVC)
1499:
1491:
1473:
1458:Antiviral drugs
1455:
1425:
1424:
1386:
1385:
1381:
1343:
1342:
1338:
1308:
1307:
1300:
1269:
1268:
1264:
1254:
1252:
1242:
1241:
1237:
1227:
1225:
1215:
1214:
1210:
1200:
1198:
1194:
1183:
1179:
1178:
1174:
1164:
1162:
1145:
1144:
1140:
1130:
1128:
1119:
1118:
1114:
1104:
1102:
1098:
1091:
1087:
1086:
1082:
1069:
1068:
1064:
1042:
1041:
1037:
1016:
1015:
1011:
1000:
998:
986:
985:
978:
968:
966:
957:
956:
945:
940:
924:
917:
908:
868:
840:
838:Adverse effects
820:
804:
745:
743:
740:(what is this?)
737:
732:
729:
724:
719:
718:
707:
704:
699:
698:
687:
662:
649:
640:
634:
595:
571:
563:
535:
515:
495:
475:
455:
435:
415:
398:
390:
370:
367:
362:
361:
329:
293:Protein binding
285:Pharmacokinetic
279:
203:
171:
164:
145:
138:
28:
23:
22:
15:
12:
11:
5:
2584:
2582:
2574:
2573:
2568:
2563:
2561:Organobromides
2558:
2553:
2548:
2543:
2538:
2533:
2523:
2522:
2518:
2517:
2505:
2482:
2481:
2466:
2465:
2464:
2463:
2460:
2449:
2443:
2437:
2436:
2433:
2432:
2429:
2428:
2426:
2425:
2420:
2415:
2410:
2405:
2400:
2395:
2390:
2385:
2380:
2375:
2370:
2365:
2360:
2354:
2352:
2348:
2347:
2345:
2344:
2339:
2334:
2329:
2324:
2319:
2314:
2309:
2304:
2299:
2294:
2289:
2284:
2279:
2274:
2269:
2264:
2259:
2254:
2248:
2246:
2242:
2241:
2239:
2238:
2232:
2230:
2224:
2223:
2221:
2220:
2214:
2212:
2206:
2205:
2203:
2202:
2196:
2194:
2188:
2187:
2185:
2184:
2177:
2175:
2166:
2162:
2161:
2159:
2158:
2153:
2151:Cobicistat (c)
2147:
2145:
2141:
2140:
2138:
2137:
2132:
2127:
2122:
2117:
2112:
2107:
2102:
2097:
2092:
2087:
2082:
2077:
2072:
2067:
2062:
2057:
2051:
2045:
2039:
2034:
2028:
2023:
2018:
2012:
2007:
2002:
1996:
1990:
1988:
1982:
1981:
1978:
1977:
1974:
1973:
1971:
1970:
1965:
1960:
1959:
1958:
1953:
1948:
1935:
1933:
1929:
1928:
1926:
1925:
1920:
1915:
1909:
1907:
1900:
1886:
1885:
1883:
1882:
1877:
1861:
1860:
1855:
1850:
1845:
1840:
1835:
1830:
1825:
1820:
1815:
1810:
1805:
1800:
1795:
1793:Abacavir (ABC)
1779:
1777:
1773:Nucleoside and
1766:
1757:
1756:
1753:
1752:
1750:
1749:
1744:
1739:
1733:
1726:
1724:
1720:
1719:
1717:
1716:
1711:
1706:
1701:
1696:
1691:
1686:
1680:
1678:
1671:
1657:
1656:
1654:
1653:
1648:
1643:
1637:
1635:
1629:
1628:
1626:
1625:
1620:
1615:
1610:
1605:
1600:
1595:
1589:
1587:
1579:
1578:
1576:
1575:
1563:
1547:
1533:
1522:
1509:
1507:
1493:
1492:
1490:
1489:
1483:
1481:
1475:
1474:
1456:
1454:
1453:
1446:
1439:
1431:
1423:
1422:
1395:(3): 323–334.
1379:
1336:
1298:
1262:
1235:
1208:
1172:
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1112:
1080:
1062:
1051:(9): 483–495.
1035:
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920:
915:
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878:and Y181C for
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585:DTXSID30181412
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305:
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268:
256:
243:
232:
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210:
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205:
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201:
188:
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180:
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172:administration
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110:
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2571:Diaryl ethers
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2353:
2351:Failed agents
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2156:Ritonavir (r)
2154:
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2024:
2022:
2019:
2016:
2013:
2011:
2008:
2006:
2003:
2000:
1997:
1995:
1992:
1991:
1989:
1987:
1983:
1969:
1966:
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1961:
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903:
901:
900:conformations
897:
893:
889:
885:
881:
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865:
863:
861:
860:liver failure
857:
854:, as well as
853:
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606:
604:
602:ECHA InfoCard
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590:
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581:
579:
570:
566:
558:
557:RCSB PDB
552:
547:
546:
544:
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531:
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518:
511:
507:
506:
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364:
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332:
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317:
313:
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304:
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294:
290:
286:
282:
276: Rx-only
269:
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107:
103:
101:
97:
93:
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87:
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71:
67:
65:
61:
58:Clinical data
56:
52:
47:
43:
38:
30:
19:
2536:Hepatotoxins
2472:
2272:Cyanovirin-N
2262:Calanolide A
1950:
1938:
1932:2 generation
1906:1 generation
1893:
1864:
1843:Elvucitabine
1833:Apricitabine
1782:
1723:2 generation
1677:1 generation
1664:
1651:Fipravirimat
1565:
1560:Semzuvolimab
1549:
1540:Cenicriviroc
1524:
1512:
1500:
1392:
1388:
1382:
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1345:
1339:
1314:
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1276:
1272:
1265:
1253:. Retrieved
1249:the original
1238:
1226:. Retrieved
1220:
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1199:. Retrieved
1192:the original
1175:
1163:. Retrieved
1159:the original
1148:
1141:
1129:. Retrieved
1125:the original
1115:
1103:. Retrieved
1096:the original
1083:
1065:
1048:
1044:
1038:
1030:the original
1021:
1012:
999:. Retrieved
991:
967:. Retrieved
962:
934:production.
925:
912:orthorhombic
909:
898:in multiple
869:
841:
821:
812:
805:
802:Medical uses
797:
764:
760:
756:
755:
744:
738:
521:NIAID ChemDB
510:ChEMBL308954
328:Elimination
214:Legal status
208:Legal status
114:License data
29:
2473:recommended
2448:from market
2398:Lersivirine
2373:Capravirine
2312:Miltefosine
2297:Griffithsin
2292:Fosdevirine
1838:Censavudine
1468:(primarily
665: g·mol
608:100.207.546
385:269055-15-4
350:Identifiers
335:41±20 hours
241:Schedule VI
100:MedlinePlus
73:Other names
64:Trade names
2525:Categories
2403:Lodenosine
2383:Droxinavir
2368:Brecanavir
2363:Atevirdine
2327:Seliciclib
2322:Scytovirin
2236:Elipovimab
2181:TRIM5alpha
1858:Stampidine
1763:inhibitors
1747:TMC-310911
1646:BMS-955176
1544:Leronlimab
1536:Vicriviroc
1255:2 February
1165:24 January
938:References
890:with some
880:nevirapine
785:subsidiary
757:Etravirine
670:3D model (
658:Molar mass
541:PDB ligand
470:0C50HW4FO1
441:ChemSpider
376:CAS Number
359:IUPAC name
322:-mediated)
303:Metabolism
133:Etravirine
34:Etravirine
2458:Phase III
2446:Withdrawn
2423:Telinavir
2418:Palinavir
2413:Mozenavir
2393:Emivirine
2388:Lasinavir
2358:Aplaviroc
2287:Foscarnet
2267:Ceragenin
1828:Amdoxovir
1641:Bevirimat
1618:BI 224436
1374:243761396
1331:1528-7483
1228:27 August
1149:Intelence
1131:29 August
1001:14 August
969:14 August
906:Chemistry
876:efavirenz
824:galactose
808:indicated
765:Intelence
341:Excretion
330:half-life
170:Routes of
144:Pregnancy
92:Monograph
86:Drugs.com
68:Intelence
18:Intelence
2556:Nitriles
2503:Medicine
2408:Loviride
1417:58567610
1409:30624801
1366:34738540
1293:15115397
1057:17933730
963:DailyMed
932:frataxin
922:Research
747:(verify)
421:DrugBank
184:ATC code
177:By mouth
159: B1
146:category
128:DailyMed
2515:Viruses
2489:Portals
2307:KP-1461
1853:Racivir
1623:MK-2048
1201:13 July
1155:aidsmap
781:Janssen
663:435.285
625:Formula
430:DB06414
396:PubChem
320:CYP2C19
239::
200:)
194: (
192:J05AG04
130::
106:a608016
2441:WHO-EM
2257:BIT225
2252:Abzyme
2183:(gene)
1870:NtRTIs
1765:(RTIs)
1415:
1407:
1372:
1364:
1329:
1291:
1105:9 July
1055:
850:, and
767:is an
696:SMILES
530:105156
501:ChEMBL
490:D04112
450:168313
410:193962
318:&
316:CYP2C9
312:CYP3A4
266:â„ž-only
264:
251:
227:
126:
76:TMC125
2245:Other
2228:BNAbs
1788:NRTIs
1567:gp120
1413:S2CID
1370:S2CID
1195:(PDF)
1184:(PDF)
1099:(PDF)
1092:(PDF)
995:(EMA)
716:InChI
672:JSmol
548:65B (
308:Liver
297:99.9%
2470:DHHS
1526:CCR5
1514:gp41
1405:PMID
1362:PMID
1327:ISSN
1289:PMID
1257:2008
1230:2009
1203:2011
1188:EMEA
1167:2008
1133:2008
1107:2008
1053:PMID
1003:2024
971:2024
783:, a
551:PDBe
481:KEGG
461:UNII
287:data
82:AHFS
1551:CD4
1470:J05
1466:HIV
1397:doi
1354:doi
1319:doi
1281:doi
862:."
830:or
787:of
773:HIV
761:ETR
574:EPA
400:CID
253:POM
197:WHO
2527::
2454::
1558:,
1542:,
1538:,
1460::
1411:.
1403:.
1393:34
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1301:^
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846:,
642:Br
639:15
633:20
554:,
314:,
272:EU
260:US
247:UK
236:CA
229:S4
223:AU
155:AU
123:US
2491::
2468:°
2056:°
2050:°
2044:°
2033:°
2017:°
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310:(
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84:/
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.