333:
310:
207:
232:
2762:
339:
238:
2792:
2777:
40:
66:
1176:
receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). IL-22 and IL-10 receptor chains play a role in cellular targeting and
1064:
Crystallization is possible if the N-linked glycosylation sites are removed in mutants of IL-22 bound with high-affinity cell-surface receptor sIL-22R1. The crystallographic asymmetric unit contained two IL-22-sIL-22R1 complexes.
1193:
survival in the liver and epithelial cells in the lung and gut similar to IL-10. In some contexts, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by the often co-expressed cytokine IL-17A
3947:
1294:), a class of potent mediators of cellular inflammatory responses. It shares use of IL-10R2 in cell signaling with other members of this family, IL-10, IL-26, IL-28A/B and IL-29.
346:
245:
3336:
3940:
2251:"Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes"
2335:
Pan HF, Zhao XF, Yuan H, Zhang WH, Li XP, Wang GH, et al. (March 2009). "Decreased serum IL-22 levels in patients with systemic lupus erythematosus".
2208:"Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH 17 cytokine interleukin-22"
768:
749:
168:
1465:"Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor"
3933:
3412:
1181:
to selectively initiate and regulate immune responses. IL-22 can contribute to immune disease through the stimulation of inflammatory responses,
5145:
4412:
3807:
2761:
1445:
5210:
5149:
5135:
5095:
2741:
1427:
1369:
stimulates IL-22 production too. On the other hand IL-22 binding protein is a soluble inhibitor which blocks receptor binding site of IL-22.
5164:
2097:
Wong CK, Lun SW, Ko FW, Wong PT, Hu SQ, Chan IH, et al. (2009). "Activation of peripheral Th17 lymphocytes in patients with asthma".
1894:
Witte K, Witte E, Sabat R, Wolk K (August 2010). "IL-28A, IL-28B, and IL-29: promising cytokines with type I interferon-like properties".
2791:
332:
2832:
2471:"The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis"
2776:
975:
5069:
1309:
chains resulting in signal transduction through receptor, IL-10R2. The IL-22/IL-22R1/IL-10R2 complex activates intracellular kinases (
968:
309:
4017:
3698:
2169:
Thompson CL, Plummer SJ, Tucker TC, Casey G, Li L (August 2010). "Interleukin-22 genetic polymorphisms and risk of colon cancer".
3228:
1414:
1393:
1527:"Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R"
231:
206:
1410:
63:
5030:
5009:
3005:
1859:
Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB (2004). "Interleukin-10 and related cytokines and receptors".
1389:
1154:
1114:
148:
3841:
3391:
3166:
345:
244:
3874:
3676:
3386:
2549:"IL-22 produced by human NK cells inhibits growth of Mycobacterium tuberculosis by enhancing phagolysosomal fusion"
3795:
3480:
2734:
338:
237:
3830:
3257:
3233:
2436:"IL-24 transgenic mice: in vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis"
813:
156:
1774:
Moore KW, de Waal
Malefyt R, Coffman RL, O'Garra A (2001). "Interleukin-10 and the interleukin-10 receptor".
4988:
4948:
4927:
4871:
4839:
4798:
4756:
4710:
4629:
4603:
4547:
4506:
4480:
4454:
4108:
2825:
1342:
1306:
1302:
1173:
1169:
1058:
1054:
794:
4563:
2136:"Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis"
4423:
4403:
4382:
4301:
4240:
4184:
4138:
4062:
3967:
3158:
1239:
2635:"Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity"
5215:
1133:. Effects involve stimulation of cell survival, proliferation and synthesis of antimicrobials including
220:
4073:
5185:
2294:"IL-17 and IL-22 are associated with protection against human kala azar caused by Leishmania donovani"
4968:
3956:
3684:
2727:
2595:
1476:
1158:
135:
4098:
2547:
Dhiman R, Indramohan M, Barnes PF, Nayak RC, Paidipally P, Rao LV, Vankayalapati R (November 2009).
4959:
4517:
4312:
4088:
3982:
3526:
2506:"Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling"
2013:"Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study"
1178:
4829:
4824:
2469:
Wolk K, Witte E, Warszawska K, Schulze-Tanzil G, Witte K, Philipp S, et al. (December 2009).
2249:
Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, et al. (April 2009).
1935:"Common polymorphisms in the interleukin-22 gene are not associated with chronic plaque psoriasis"
1812:"Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A"
4809:
4721:
4700:
4149:
4083:
4042:
3986:
3959:
3693:
3650:
3565:
3408:
3272:
2818:
2280:
2194:
2122:
2085:
2054:
de Moura PR, Watanabe L, Bleicher L, Colau D, Dumoutier L, Lemaire MM, et al. (April 2009).
1964:
1366:
1354:
1150:
180:
4690:
4558:
4465:
4444:
4195:
4164:
4159:
4103:
4022:
2504:
Eyerich S, Eyerich K, Pennino D, Carbone T, Nasorri F, Pallotta S, et al. (December 2009).
951:
930:
904:
883:
4736:
4169:
3997:
3992:
4342:
4327:
4291:
4261:
4007:
3557:
3176:
3042:
2707:
2664:
2621:
2570:
2535:
2492:
2457:
2422:
2387:
2352:
2323:
2272:
2237:
2186:
2157:
2114:
2077:
2042:
1999:
1956:
1911:
1876:
1841:
1791:
1756:
1707:
1653:
1612:
1571:
1548:
1504:
1314:
128:
56:
1872:
5180:
3869:
3790:
3658:
3347:
3181:
2697:
2689:
2654:
2646:
2611:
2603:
2584:"A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity"
2560:
2525:
2517:
2482:
2447:
2412:
2377:
2344:
2313:
2305:
2262:
2227:
2219:
2206:
Hughes T, Becknell B, McClory S, Briercheck E, Freud AG, Zhang X, et al. (April 2009).
2178:
2147:
2106:
2067:
2032:
2024:
1989:
1946:
1903:
1868:
1831:
1823:
1783:
1746:
1738:
1697:
1689:
1643:
1602:
1594:
1538:
1494:
1484:
1098:
425:
356:
300:
255:
4656:
4652:
4648:
2011:
Silverberg MS, Cho JH, Rioux JD, McGovern DP, Wu J, Annese V, et al. (February 2009).
4972:
3396:
3082:
2582:
Cella M, Fuchs A, Vermi W, Facchetti F, Otero K, Lennerz JK, et al. (February 2009).
2292:
Pitta MG, Romano A, Cabantous S, Henri S, Hammad A, Kouriba B, et al. (August 2009).
1693:
1243:
400:
176:
2366:"Memory IL-22-producing CD4+ T cells specific for Candida albicans are present in humans"
1933:
Weger W, Hofer A, Wolf P, El-Shabrawi Y, Renner W, Kerl H, Salmhofer W (September 2009).
2599:
2399:
Sekikawa A, Fukui H, Suzuki K, Karibe T, Fujii S, Ichikawa K, et al. (March 2010).
1976:
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, et al. (April 2010).
1480:
1168:
IL-22 biological activity is initiated by binding to a cell-surface complex composed of
5170:
5160:
5155:
5141:
5127:
5117:
5112:
5059:
5041:
5020:
4999:
4978:
4964:
4938:
4882:
4814:
4777:
4772:
4767:
4731:
4726:
4640:
4619:
4573:
4522:
4491:
4470:
4205:
4174:
3910:
3905:
3760:
3756:
3738:
3733:
3536:
3531:
3521:
3516:
3511:
3506:
3497:
3466:
3461:
3456:
3435:
3430:
3425:
3420:
3375:
3370:
3365:
3360:
3308:
3293:
3284:
2841:
2702:
2677:
2659:
2634:
2616:
2583:
2530:
2505:
2318:
2293:
2232:
2207:
2037:
2012:
1836:
1811:
1751:
1726:
1702:
1677:
1607:
1582:
1346:
1330:
1326:
1291:
1287:
1283:
1279:
1275:
1259:
683:
678:
673:
668:
663:
647:
642:
626:
621:
616:
5204:
4912:
4568:
4434:
4393:
4317:
4251:
4200:
4154:
4093:
3978:
3900:
3895:
3890:
3836:
3785:
3451:
3355:
3331:
3326:
3303:
3298:
3289:
3280:
3062:
1951:
1934:
1787:
1525:
Xie MH, Aggarwal S, Ho WH, Foster J, Zhang Z, Stinson J, et al. (October 2000).
1499:
1464:
1182:
1146:
603:
2284:
2198:
2126:
2089:
1968:
160:
5086:
4907:
4593:
4588:
4583:
4332:
4271:
4230:
3381:
3213:
1978:"New genetic associations detected in a host response study to hepatitis B vaccine"
1211:
1134:
1126:
1074:
418:
197:
3925:
2072:
2055:
1907:
1742:
1301:
receptor-related proteins CRF2-4 and IL-22R. It forms cell surface complexes with
2267:
2250:
2223:
1648:
1631:
1061:
subunits. IL-22R is expressed on tissue cells, and it is absent on immune cells.
184:
4917:
4897:
4860:
4695:
4685:
4537:
4532:
4367:
4337:
4276:
4118:
4078:
4037:
4032:
3802:
3748:
3489:
3248:
3171:
1450:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1432:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1050:
2650:
2417:
2400:
2056:"Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22"
1469:
Proceedings of the
National Academy of Sciences of the United States of America
501:
139:, IL-21, IL-22, IL-D110, IL-TIF, ILTIF, TIFIL-23, TIFa, zcyto18, interleukin 22
4902:
4892:
4787:
4680:
4675:
4496:
4357:
4347:
4281:
4215:
4128:
4123:
4052:
3855:
3548:
3238:
3198:
2348:
2182:
2110:
1598:
1318:
1298:
1207:
1190:
1130:
1122:
1118:
317:
214:
164:
39:
17:
2565:
2548:
2452:
2435:
4372:
4362:
4352:
4225:
2860:
2810:
1162:
1090:
713:
561:
439:
384:
371:
283:
270:
172:
2711:
2668:
2625:
2574:
2539:
2496:
2461:
2426:
2391:
2356:
2327:
2276:
2241:
2190:
2161:
2118:
2081:
2046:
2003:
1960:
1915:
1880:
1845:
1795:
1760:
1711:
1657:
1616:
1552:
1543:
1526:
1508:
1489:
1053:
cytokine. IL-22 binds to a heterodimeric cell surface receptor composed of
2487:
2470:
2382:
2365:
1630:
Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R (August 2004).
1145:. IL-22 thus participates in both wound healing and in protection against
1015:
1010:
4012:
3850:
2845:
2693:
1827:
1810:
Sonnenberg GF, Nair MG, Kirn TJ, Zaph C, Fouser LA, Artis D (June 2010).
1271:
1231:
1203:
1186:
1142:
1110:
1082:
999:
858:
839:
2607:
1994:
1977:
5131:
4614:
2364:
Liu Y, Yang B, Zhou M, Li L, Zhou H, Zhang J, et al. (June 2009).
1031:
825:
780:
2405:
Laboratory
Investigation; A Journal of Technical Methods and Pathology
2152:
2135:
1575:
1073:
IL-22 is produced by several populations of immune cells at a site of
105:
101:
97:
93:
89:
85:
4746:
3728:
3625:
3620:
3615:
3610:
3605:
3600:
3318:
3123:
3107:
3102:
3097:
3092:
3087:
3077:
3072:
2521:
2309:
1358:
1350:
1251:
1235:
1227:
1106:
1078:
983:
735:
2028:
5053:
5049:
5045:
4664:
4660:
4644:
3764:
3723:
3718:
3713:
3708:
3703:
3640:
3630:
3595:
3590:
3585:
3580:
3575:
3570:
3223:
3218:
3208:
3193:
3188:
3067:
3057:
3052:
3047:
3037:
3032:
3026:
3010:
3000:
2995:
2990:
2985:
2980:
2975:
2970:
2965:
2959:
2954:
2949:
2944:
2939:
2934:
2929:
2924:
2678:"Circulating Th17, Th22, and Th1 cells are increased in psoriasis"
1322:
1247:
1215:
1138:
2337:
Clinica
Chimica Acta; International Journal of Clinical Chemistry
698:
694:
3688:
3635:
3203:
3144:
3139:
2919:
2914:
2909:
2904:
2898:
2892:
2886:
2880:
2875:
2401:"Involvement of the IL-22/REG Ialpha axis in ulcerative colitis"
1362:
1310:
1223:
1219:
1038:
152:
3929:
2814:
2723:
5121:
2719:
2676:
Kagami S, Rizzo HL, Lee JJ, Koguchi Y, Blauvelt A (May 2010).
2633:
Sanjabi S, Zenewicz LA, Kamanaka M, Flavell RA (August 2009).
1255:
1583:"Structure of IL-22 bound to its high-affinity IL-22R1 chain"
1463:
Dumoutier L, Van Roost E, Colau D, Renauld JC (August 2000).
1149:. IL-22 dysregulation takes part in pathogenesis of several
1125:. IL-22 takes effect on non-hematopoietic cells – mainly
1727:"Emerging role of interleukin-22 in autoimmune diseases"
408:
2770:: CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22
1676:
Dudakov JA, Hanash AM, van den Brink MR (2015-03-21).
573:
5105:
5085:
5078:
5029:
5008:
4987:
4947:
4926:
4870:
4838:
4797:
4755:
4709:
4628:
4602:
4546:
4505:
4479:
4453:
4422:
4402:
4381:
4300:
4239:
4183:
4137:
4061:
3966:
3820:
3778:
3747:
3675:
3649:
3556:
3547:
3488:
3479:
3444:
3407:
3345:
3317:
3271:
3256:
3247:
3157:
3132:
3116:
3019:
2868:
2859:
2852:
944:
923:
897:
876:
544:
dentate gyrus of hippocampal formation granule cell
2800:: Crystal Structure of Insect Cell Expressed IL-22
1581:Jones BC, Logsdon NJ, Walter MR (September 2008).
1406:
1404:
1402:
1385:
1383:
1381:
355:
254:
2785:: Crystal structure of the IL-22/IL-22R1 complex
2134:Shen H, Goodall JC, Hill Gaston JS (June 2009).
1725:Pan HF, Li XP, Zheng SG, Ye DQ (February 2013).
1632:"IL-22 increases the innate immunity of tissues"
1566:
1564:
1562:
1520:
1518:
1411:GRCm38: Ensembl release 89: ENSMUSG00000090461
3941:
2826:
2735:
1678:"Interleukin-22: immunobiology and pathology"
8:
1390:GRCh38: Ensembl release 89: ENSG00000127318
1341:IL-22 production is induced mainly through
1333:signaling when IL-22R1 pairs with IL-20R2.
5082:
3948:
3934:
3926:
3553:
3485:
3268:
3253:
2865:
2856:
2833:
2819:
2811:
2742:
2728:
2720:
1345:receptor signalling. IL-23 is produced by
709:
599:
396:
295:
192:
74:
2701:
2658:
2615:
2564:
2529:
2486:
2451:
2416:
2381:
2317:
2266:
2231:
2151:
2071:
2036:
1993:
1950:
1835:
1750:
1701:
1647:
1606:
1542:
1498:
1488:
679:regulation of signaling receptor activity
5113:Interleukin 14 (taxilin alpha, HMW-BCGF)
2682:The Journal of Investigative Dermatology
2255:The Pediatric Infectious Disease Journal
1873:10.1146/annurev.immunol.22.012703.104622
1321:) and transcription factors, especially
2757:
1377:
1278:family or IL-10 superfamily (including
1214:cells of following tissues and organs:
27:Protein, encoded in humans by IL22 gene
4411:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
29:
2510:The Journal of Clinical Investigation
2298:The Journal of Clinical Investigation
1694:10.1146/annurev-immunol-032414-112123
1206:are mostly non-hematopoietic cells –
360:
321:
316:
259:
218:
213:
7:
1896:Cytokine & Growth Factor Reviews
1816:The Journal of Experimental Medicine
1731:Cytokine & Growth Factor Reviews
1671:
1669:
1667:
1531:The Journal of Biological Chemistry
684:cytokine-mediated signaling pathway
941:
920:
894:
873:
849:
830:
804:
785:
759:
740:
578:
496:
434:
413:
25:
1034:that in humans is encoded by the
2790:
2775:
2760:
1952:10.1111/j.1600-0625.2009.00840.x
1788:10.1146/annurev.immunol.19.1.683
1270:IL-22 is a member of a group of
344:
337:
331:
308:
243:
236:
230:
205:
38:
4939:Interleukin 27 (interleukin 30)
2639:Current Opinion in Pharmacology
2434:He M, Liang P (February 2010).
1357:especially in combination with
622:interleukin-22 receptor binding
2475:European Journal of Immunology
2370:European Journal of Immunology
562:More reference expression data
1:
2073:10.1016/j.febslet.2009.03.006
1908:10.1016/j.cytogfr.2010.04.002
1743:10.1016/j.cytogfr.2012.07.002
329:
228:
5211:Genes on human chromosome 12
2268:10.1097/INF.0b013e31818e2aa9
2224:10.1182/blood-2008-12-192443
2099:Immunological Investigations
1649:10.1016/j.immuni.2004.07.007
1155:systemic lupus erythematosus
4289:Antisense oligonucleotides:
2171:Cancer Causes & Control
1861:Annual Review of Immunology
1776:Annual Review of Immunology
1682:Annual Review of Immunology
1297:IL-22, signals through the
5232:
2651:10.1016/j.coph.2009.04.008
2418:10.1038/labinvest.2009.147
976:Chr 10: 118.13 – 118.13 Mb
664:response to glucocorticoid
3796:Colony-stimulating factor
2755:
2349:10.1016/j.cca.2008.11.009
2183:10.1007/s10552-010-9542-5
2111:10.1080/08820130903062756
1599:10.1016/j.str.2008.06.005
1446:"Mouse PubMed Reference:"
1428:"Human PubMed Reference:"
1014:
1009:
1005:
998:
982:
963:
948:
927:
916:
901:
880:
869:
856:
852:
837:
833:
824:
811:
807:
792:
788:
779:
766:
762:
747:
743:
734:
719:
712:
708:
692:
602:
598:
586:
581:
572:
559:
508:
499:
446:
437:
407:
399:
395:
378:
365:
328:
307:
298:
294:
277:
264:
227:
204:
195:
191:
146:
143:
133:
126:
121:
82:
77:
60:
55:
50:
46:
37:
32:
3831:proinflammatory cytokine
2566:10.4049/jimmunol.0902587
2453:10.4049/jimmunol.0901829
2140:Arthritis and Rheumatism
1939:Experimental Dermatology
1337:Regulation of production
969:Chr 12: 68.25 – 68.25 Mb
4979:Interleukin-29 (IFN-λ1)
4124:Daclizumab (dacliximab)
4109:Tucotuzumab celmoleukin
1189:. IL-22 also promotes
466:epithelium of esophagus
4960:Interferon λ4 (IFN-λ4)
4053:Rilonacept (IL-1 Trap)
2962:/PARC/DCCK1/AMAC1/MIP4
1544:10.1074/jbc.M005304200
1490:10.1073/pnas.170291697
1240:gastrointestinal tract
540:neural layer of retina
4883:Interleukin 23 (SGRF)
4564:Cintredekin besudotox
4492:Interleukin 11 (AGIF)
4471:Interleukin 10 (CSIF)
2553:Journal of Immunology
2488:10.1002/eji.200939687
2440:Journal of Immunology
2383:10.1002/eji.200838811
1349:after recognition of
674:inflammatory response
323:Chromosome 10 (mouse)
221:Chromosome 12 (human)
3957:Interleukin receptor
2694:10.1038/jid.2009.399
1828:10.1084/jem.20092054
1159:rheumatoid arthritis
669:acute-phase response
648:extracellular region
78:List of PDB id codes
51:Available structures
4089:Denileukin diftitox
3527:Interferon type III
2608:10.1038/nature07537
2600:2009Natur.457..722C
1995:10.1038/gene.2010.1
1481:2000PNAS...9710144D
1355:Toll-like receptors
1179:signal transduction
1151:autoimmune diseases
1077:. Producers are αβ
643:extracellular space
4661:E (interleukin 25)
1982:Genes and Immunity
814:ENSMUSG00000090461
657:Biological process
636:Cellular component
610:Molecular function
5198:
5197:
5194:
5193:
5163:(signals through
5144:(signals through
5130:(signals through
5120:(signals through
4744:Binding proteins:
4074:Adargileukin alfa
3923:
3922:
3816:
3815:
3774:
3773:
3671:
3670:
3667:
3666:
3475:
3474:
3153:
3152:
2808:
2807:
2153:10.1002/art.24568
1025:
1024:
1021:
1020:
994:
993:
959:
958:
938:
937:
912:
911:
891:
890:
865:
864:
846:
845:
820:
819:
801:
800:
775:
774:
756:
755:
704:
703:
627:cytokine activity
594:
593:
590:
589:
568:
567:
555:
554:
528:cerebellar cortex
493:
492:
462:mucosa of pharynx
391:
390:
290:
289:
117:
116:
113:
112:
61:Ortholog search:
16:(Redirected from
5223:
5186:Efineptakin alfa
5181:Efavaleukin alfa
5083:
4050:Decoy receptors:
3950:
3943:
3936:
3927:
3554:
3486:
3269:
3254:
2866:
2857:
2835:
2828:
2821:
2812:
2794:
2779:
2764:
2744:
2737:
2730:
2721:
2715:
2705:
2672:
2662:
2629:
2619:
2578:
2568:
2543:
2533:
2522:10.1172/JCI40202
2500:
2490:
2465:
2455:
2430:
2420:
2395:
2385:
2360:
2331:
2321:
2310:10.1172/JCI38813
2288:
2270:
2245:
2235:
2202:
2165:
2155:
2130:
2093:
2075:
2050:
2040:
2007:
1997:
1972:
1954:
1920:
1919:
1891:
1885:
1884:
1856:
1850:
1849:
1839:
1807:
1801:
1799:
1771:
1765:
1764:
1754:
1722:
1716:
1715:
1705:
1673:
1662:
1661:
1651:
1627:
1621:
1620:
1610:
1578:
1568:
1557:
1556:
1546:
1522:
1513:
1512:
1502:
1492:
1460:
1454:
1453:
1442:
1436:
1435:
1424:
1418:
1408:
1397:
1387:
1325:. It can induce
1244:synovial tissues
1202:Targets of this
1131:epithelial cells
1007:
1006:
978:
971:
954:
942:
933:
921:
917:RefSeq (protein)
907:
895:
886:
874:
850:
831:
805:
786:
760:
741:
710:
600:
579:
564:
524:secondary oocyte
504:
502:Top expressed in
497:
442:
440:Top expressed in
435:
414:
397:
387:
374:
363:
348:
341:
335:
324:
312:
296:
286:
273:
262:
247:
240:
234:
223:
209:
193:
187:
185:IL22 - orthologs
138:
131:
108:
75:
69:
48:
47:
42:
30:
21:
5231:
5230:
5226:
5225:
5224:
5222:
5221:
5220:
5201:
5200:
5199:
5190:
5101:
5074:
5025:
5004:
4983:
4943:
4922:
4866:
4863:(against IL-22)
4834:
4793:
4790:(against IL-20)
4751:
4705:
4624:
4598:
4542:
4501:
4475:
4449:
4418:
4398:
4377:
4296:
4235:
4179:
4133:
4057:
3962:
3954:
3924:
3919:
3885:
3864:
3822:
3812:
3770:
3743:
3663:
3645:
3543:
3471:
3440:
3403:
3341:
3313:
3264:
3262:
3260:
3243:
3149:
3128:
3112:
3015:
2848:
2839:
2809:
2804:
2801:
2795:
2786:
2780:
2771:
2765:
2751:
2748:
2718:
2675:
2632:
2594:(7230): 722–5.
2581:
2559:(10): 6639–45.
2546:
2516:(12): 3573–85.
2503:
2481:(12): 3570–81.
2468:
2433:
2398:
2363:
2343:(1–2): 179–80.
2334:
2291:
2248:
2218:(17): 4008–10.
2205:
2168:
2133:
2096:
2053:
2017:Nature Genetics
2010:
1975:
1932:
1928:
1926:Further reading
1923:
1893:
1892:
1888:
1858:
1857:
1853:
1822:(6): 1293–305.
1809:
1808:
1804:
1773:
1772:
1768:
1724:
1723:
1719:
1675:
1674:
1665:
1629:
1628:
1624:
1580:
1570:
1569:
1560:
1537:(40): 31335–9.
1524:
1523:
1516:
1475:(18): 10144–9.
1462:
1461:
1457:
1444:
1443:
1439:
1426:
1425:
1421:
1409:
1400:
1388:
1379:
1375:
1347:dendritic cells
1339:
1268:
1200:
1102:
1094:
1086:
1071:
1047:
1016:View/Edit Mouse
1011:View/Edit Human
974:
967:
964:Location (UCSC)
950:
929:
903:
882:
795:ENSG00000127318
688:
652:
631:
617:protein binding
560:
551:
546:
542:
538:
534:
530:
526:
522:
518:
514:
500:
489:
486:urinary bladder
484:
480:
478:muscle of thigh
476:
472:
468:
464:
460:
456:
452:
438:
382:
369:
361:
351:
350:
349:
342:
322:
299:Gene location (
281:
268:
260:
250:
249:
248:
241:
219:
196:Gene location (
147:
134:
127:
84:
62:
28:
23:
22:
15:
12:
11:
5:
5229:
5227:
5219:
5218:
5213:
5203:
5202:
5196:
5195:
5192:
5191:
5189:
5188:
5183:
5174:
5173:
5171:Interleukin 35
5168:
5161:Interleukin 34
5158:
5156:Interleukin 32
5153:
5142:Interleukin 26
5139:
5128:Interleukin 24
5125:
5118:Interleukin 16
5115:
5109:
5107:
5103:
5102:
5100:
5099:
5091:
5089:
5080:
5076:
5075:
5073:
5072:
5063:
5062:
5060:Interleukin 38
5057:
5042:Interleukin 36
5035:
5033:
5027:
5026:
5024:
5023:
5021:Interleukin 33
5014:
5012:
5006:
5005:
5003:
5002:
5000:Interleukin 31
4993:
4991:
4985:
4984:
4982:
4981:
4976:
4965:Interleukin 28
4962:
4953:
4951:
4945:
4944:
4942:
4941:
4932:
4930:
4924:
4923:
4921:
4920:
4915:
4910:
4905:
4900:
4895:
4886:
4885:
4876:
4874:
4868:
4867:
4865:
4864:
4854:
4853:
4851:Interleukin 22
4844:
4842:
4836:
4835:
4833:
4832:
4827:
4818:
4817:
4815:Interleukin 21
4812:
4803:
4801:
4795:
4794:
4792:
4791:
4781:
4780:
4778:Interleukin 24
4775:
4773:Interleukin 20
4770:
4768:Interleukin 19
4761:
4759:
4753:
4752:
4750:
4749:
4740:
4739:
4734:
4732:Interleukin 37
4729:
4727:Interleukin 18
4724:
4715:
4713:
4707:
4706:
4704:
4703:
4698:
4693:
4688:
4683:
4678:
4669:
4668:
4641:Interleukin 17
4634:
4632:
4626:
4625:
4623:
4622:
4620:Interleukin 15
4617:
4608:
4606:
4600:
4599:
4597:
4596:
4591:
4586:
4577:
4576:
4574:Interleukin 13
4571:
4566:
4561:
4552:
4550:
4544:
4543:
4541:
4540:
4535:
4526:
4525:
4523:Interleukin 12
4520:
4511:
4509:
4503:
4502:
4500:
4499:
4494:
4485:
4483:
4477:
4476:
4474:
4473:
4468:
4459:
4457:
4451:
4450:
4448:
4447:
4438:
4437:
4428:
4426:
4420:
4419:
4417:
4416:
4408:
4406:
4400:
4399:
4397:
4396:
4387:
4385:
4379:
4378:
4376:
4375:
4370:
4365:
4360:
4355:
4350:
4345:
4340:
4335:
4330:
4321:
4320:
4315:
4306:
4304:
4298:
4297:
4295:
4294:
4285:
4284:
4279:
4274:
4265:
4264:
4255:
4254:
4245:
4243:
4237:
4236:
4234:
4233:
4228:
4219:
4218:
4209:
4208:
4206:Interleukin 13
4203:
4198:
4189:
4187:
4181:
4180:
4178:
4177:
4175:Promegapoietin
4172:
4167:
4162:
4157:
4152:
4143:
4141:
4135:
4134:
4132:
4131:
4126:
4121:
4112:
4111:
4106:
4101:
4099:Pegaldesleukin
4096:
4091:
4086:
4081:
4076:
4067:
4065:
4059:
4058:
4056:
4055:
4046:
4045:
4040:
4035:
4026:
4025:
4020:
4015:
4010:
4001:
4000:
3995:
3990:
3972:
3970:
3964:
3963:
3955:
3953:
3952:
3945:
3938:
3930:
3921:
3920:
3918:
3917:
3916:
3915:
3914:
3913:
3908:
3903:
3898:
3893:
3883:
3879:
3878:
3877:
3872:
3862:
3853:
3847:
3846:
3845:
3844:
3839:
3826:
3824:
3818:
3817:
3814:
3813:
3811:
3810:
3805:
3800:
3799:
3798:
3793:
3782:
3780:
3776:
3775:
3772:
3771:
3769:
3768:
3753:
3751:
3745:
3744:
3742:
3741:
3736:
3731:
3726:
3721:
3716:
3711:
3706:
3701:
3696:
3691:
3681:
3679:
3677:Ig superfamily
3673:
3672:
3669:
3668:
3665:
3664:
3662:
3661:
3655:
3653:
3647:
3646:
3644:
3643:
3638:
3633:
3628:
3623:
3618:
3613:
3608:
3603:
3598:
3593:
3588:
3583:
3578:
3573:
3568:
3562:
3560:
3551:
3545:
3544:
3542:
3541:
3540:
3539:
3534:
3524:
3519:
3514:
3509:
3504:
3494:
3492:
3483:
3477:
3476:
3473:
3472:
3470:
3469:
3464:
3459:
3454:
3448:
3446:
3442:
3441:
3439:
3438:
3433:
3428:
3423:
3417:
3415:
3405:
3404:
3402:
3401:
3400:
3399:
3394:
3389:
3384:
3373:
3368:
3363:
3358:
3352:
3350:
3343:
3342:
3340:
3339:
3334:
3329:
3323:
3321:
3315:
3314:
3312:
3311:
3306:
3301:
3296:
3287:
3277:
3275:
3266:
3251:
3245:
3244:
3242:
3241:
3236:
3231:
3226:
3221:
3216:
3211:
3206:
3201:
3196:
3191:
3186:
3185:
3184:
3179:
3169:
3163:
3161:
3155:
3154:
3151:
3150:
3148:
3147:
3142:
3136:
3134:
3130:
3129:
3127:
3126:
3120:
3118:
3114:
3113:
3111:
3110:
3105:
3100:
3095:
3090:
3085:
3080:
3075:
3070:
3065:
3060:
3055:
3050:
3045:
3040:
3035:
3030:
3023:
3021:
3017:
3016:
3014:
3013:
3008:
3003:
2998:
2993:
2988:
2983:
2978:
2973:
2968:
2963:
2957:
2952:
2947:
2942:
2937:
2932:
2927:
2922:
2917:
2912:
2907:
2902:
2896:
2890:
2884:
2878:
2872:
2870:
2863:
2854:
2850:
2849:
2842:Cell signaling
2840:
2838:
2837:
2830:
2823:
2815:
2806:
2805:
2803:
2802:
2796:
2789:
2787:
2781:
2774:
2772:
2766:
2759:
2756:
2753:
2752:
2749:
2747:
2746:
2739:
2732:
2724:
2717:
2716:
2688:(5): 1373–83.
2673:
2630:
2579:
2544:
2501:
2466:
2431:
2411:(3): 496–505.
2396:
2361:
2332:
2304:(8): 2379–87.
2289:
2246:
2203:
2177:(8): 1165–70.
2166:
2146:(6): 1647–56.
2131:
2094:
2051:
2029:10.1038/ng.275
2008:
1973:
1929:
1927:
1924:
1922:
1921:
1886:
1851:
1802:
1766:
1717:
1663:
1622:
1593:(9): 1333–44.
1558:
1514:
1455:
1437:
1419:
1398:
1376:
1374:
1371:
1338:
1335:
1267:
1264:
1260:adipose tissue
1199:
1196:
1105:along with γδ
1100:
1092:
1084:
1070:
1067:
1046:
1043:
1028:Interleukin-22
1023:
1022:
1019:
1018:
1013:
1003:
1002:
996:
995:
992:
991:
989:
987:
980:
979:
972:
965:
961:
960:
957:
956:
946:
945:
939:
936:
935:
925:
924:
918:
914:
913:
910:
909:
899:
898:
892:
889:
888:
878:
877:
871:
867:
866:
863:
862:
854:
853:
847:
844:
843:
835:
834:
828:
822:
821:
818:
817:
809:
808:
802:
799:
798:
790:
789:
783:
777:
776:
773:
772:
764:
763:
757:
754:
753:
745:
744:
738:
732:
731:
726:
721:
717:
716:
706:
705:
702:
701:
690:
689:
687:
686:
681:
676:
671:
666:
660:
658:
654:
653:
651:
650:
645:
639:
637:
633:
632:
630:
629:
624:
619:
613:
611:
607:
606:
596:
595:
592:
591:
588:
587:
584:
583:
576:
570:
569:
566:
565:
557:
556:
553:
552:
550:
549:
545:
541:
537:
533:
529:
525:
521:
517:
516:primary oocyte
513:
509:
506:
505:
494:
491:
490:
488:
487:
483:
479:
475:
471:
467:
463:
459:
455:
451:
447:
444:
443:
431:
430:
422:
411:
405:
404:
401:RNA expression
393:
392:
389:
388:
380:
376:
375:
367:
364:
359:
353:
352:
343:
336:
330:
326:
325:
320:
314:
313:
305:
304:
292:
291:
288:
287:
279:
275:
274:
266:
263:
258:
252:
251:
242:
235:
229:
225:
224:
217:
211:
210:
202:
201:
189:
188:
145:
141:
140:
132:
124:
123:
119:
118:
115:
114:
111:
110:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
18:Interleukin-22
14:
13:
10:
9:
6:
4:
3:
2:
5228:
5217:
5214:
5212:
5209:
5208:
5206:
5187:
5184:
5182:
5179:
5176:
5175:
5172:
5169:
5166:
5162:
5159:
5157:
5154:
5151:
5147:
5143:
5140:
5137:
5133:
5129:
5126:
5123:
5119:
5116:
5114:
5111:
5110:
5108:
5104:
5097:
5093:
5092:
5090:
5088:
5084:
5081:
5077:
5071:
5068:
5065:
5064:
5061:
5058:
5055:
5051:
5047:
5043:
5040:
5037:
5036:
5034:
5032:
5028:
5022:
5019:
5016:
5015:
5013:
5011:
5007:
5001:
4998:
4995:
4994:
4992:
4990:
4986:
4980:
4977:
4974:
4970:
4966:
4963:
4961:
4958:
4955:
4954:
4952:
4950:
4946:
4940:
4937:
4934:
4933:
4931:
4929:
4925:
4919:
4916:
4914:
4913:Tildrakizumab
4911:
4909:
4906:
4904:
4901:
4899:
4896:
4894:
4891:
4888:
4887:
4884:
4881:
4878:
4877:
4875:
4873:
4869:
4862:
4859:
4856:
4855:
4852:
4849:
4846:
4845:
4843:
4841:
4837:
4831:
4828:
4826:
4823:
4820:
4819:
4816:
4813:
4811:
4808:
4805:
4804:
4802:
4800:
4796:
4789:
4786:
4783:
4782:
4779:
4776:
4774:
4771:
4769:
4766:
4763:
4762:
4760:
4758:
4754:
4748:
4745:
4742:
4741:
4738:
4735:
4733:
4730:
4728:
4725:
4723:
4720:
4717:
4716:
4714:
4712:
4708:
4702:
4699:
4697:
4694:
4692:
4689:
4687:
4684:
4682:
4679:
4677:
4674:
4671:
4670:
4666:
4662:
4658:
4654:
4650:
4646:
4642:
4639:
4636:
4635:
4633:
4631:
4627:
4621:
4618:
4616:
4613:
4610:
4609:
4607:
4605:
4601:
4595:
4592:
4590:
4587:
4585:
4582:
4579:
4578:
4575:
4572:
4570:
4569:Interleukin 4
4567:
4565:
4562:
4560:
4557:
4554:
4553:
4551:
4549:
4545:
4539:
4536:
4534:
4531:
4528:
4527:
4524:
4521:
4519:
4518:Edodekin alfa
4516:
4513:
4512:
4510:
4508:
4504:
4498:
4495:
4493:
4490:
4487:
4486:
4484:
4482:
4478:
4472:
4469:
4467:
4464:
4461:
4460:
4458:
4456:
4452:
4446:
4443:
4440:
4439:
4436:
4435:Interleukin 9
4433:
4430:
4429:
4427:
4425:
4421:
4414:
4410:
4409:
4407:
4405:
4401:
4395:
4394:Interleukin 7
4392:
4389:
4388:
4386:
4384:
4380:
4374:
4371:
4369:
4366:
4364:
4361:
4359:
4356:
4354:
4351:
4349:
4346:
4344:
4341:
4339:
4336:
4334:
4331:
4329:
4326:
4323:
4322:
4319:
4318:Interleukin 6
4316:
4314:
4313:Atexakin alfa
4311:
4308:
4307:
4305:
4303:
4299:
4293:
4290:
4287:
4286:
4283:
4280:
4278:
4275:
4273:
4270:
4267:
4266:
4263:
4260:
4257:
4256:
4253:
4252:Interleukin 5
4250:
4247:
4246:
4244:
4242:
4238:
4232:
4229:
4227:
4224:
4221:
4220:
4217:
4214:
4211:
4210:
4207:
4204:
4202:
4201:Interleukin 4
4199:
4197:
4194:
4191:
4190:
4188:
4186:
4182:
4176:
4173:
4171:
4168:
4166:
4163:
4161:
4158:
4156:
4155:Interleukin 3
4153:
4151:
4148:
4145:
4144:
4142:
4140:
4136:
4130:
4127:
4125:
4122:
4120:
4117:
4114:
4113:
4110:
4107:
4105:
4102:
4100:
4097:
4095:
4094:Interleukin 2
4092:
4090:
4087:
4085:
4082:
4080:
4077:
4075:
4072:
4069:
4068:
4066:
4064:
4060:
4054:
4051:
4048:
4047:
4044:
4041:
4039:
4036:
4034:
4031:
4028:
4027:
4024:
4021:
4019:
4016:
4014:
4011:
4009:
4006:
4003:
4002:
3999:
3996:
3994:
3991:
3988:
3984:
3980:
3979:Interleukin 1
3977:
3974:
3973:
3971:
3969:
3965:
3961:
3958:
3951:
3946:
3944:
3939:
3937:
3932:
3931:
3928:
3912:
3909:
3907:
3904:
3902:
3899:
3897:
3894:
3892:
3889:
3888:
3887:
3880:
3876:
3873:
3871:
3868:
3867:
3866:
3859:
3858:
3857:
3854:
3852:
3849:
3848:
3843:
3840:
3838:
3835:
3834:
3833:
3832:
3828:
3827:
3825:
3819:
3809:
3806:
3804:
3801:
3797:
3794:
3792:
3789:
3788:
3787:
3786:Hematopoietic
3784:
3783:
3781:
3777:
3766:
3762:
3758:
3755:
3754:
3752:
3750:
3746:
3740:
3737:
3735:
3732:
3730:
3727:
3725:
3722:
3720:
3717:
3715:
3712:
3710:
3707:
3705:
3702:
3700:
3697:
3695:
3692:
3690:
3686:
3683:
3682:
3680:
3678:
3674:
3660:
3657:
3656:
3654:
3652:
3648:
3642:
3639:
3637:
3634:
3632:
3629:
3627:
3624:
3622:
3619:
3617:
3614:
3612:
3609:
3607:
3604:
3602:
3599:
3597:
3594:
3592:
3589:
3587:
3584:
3582:
3579:
3577:
3574:
3572:
3569:
3567:
3564:
3563:
3561:
3559:
3555:
3552:
3550:
3546:
3538:
3535:
3533:
3530:
3529:
3528:
3525:
3523:
3520:
3518:
3515:
3513:
3510:
3508:
3505:
3503:
3499:
3496:
3495:
3493:
3491:
3487:
3484:
3482:
3478:
3468:
3465:
3463:
3460:
3458:
3455:
3453:
3450:
3449:
3447:
3443:
3437:
3434:
3432:
3429:
3427:
3424:
3422:
3419:
3418:
3416:
3414:
3410:
3406:
3398:
3395:
3393:
3390:
3388:
3385:
3383:
3379:
3378:
3377:
3374:
3372:
3369:
3367:
3364:
3362:
3359:
3357:
3354:
3353:
3351:
3349:
3344:
3338:
3335:
3333:
3330:
3328:
3325:
3324:
3322:
3320:
3316:
3310:
3307:
3305:
3302:
3300:
3297:
3295:
3291:
3288:
3286:
3282:
3279:
3278:
3276:
3274:
3270:
3267:
3259:
3255:
3252:
3250:
3246:
3240:
3237:
3235:
3232:
3230:
3227:
3225:
3222:
3220:
3217:
3215:
3212:
3210:
3207:
3205:
3202:
3200:
3197:
3195:
3194:TNFSF5/CD40LG
3192:
3190:
3187:
3183:
3180:
3178:
3175:
3174:
3173:
3170:
3168:
3165:
3164:
3162:
3160:
3156:
3146:
3143:
3141:
3138:
3137:
3135:
3131:
3125:
3122:
3121:
3119:
3115:
3109:
3106:
3104:
3101:
3099:
3096:
3094:
3091:
3089:
3086:
3084:
3081:
3079:
3076:
3074:
3071:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3028:
3025:
3024:
3022:
3018:
3012:
3009:
3007:
3004:
3002:
2999:
2997:
2994:
2992:
2989:
2987:
2984:
2982:
2979:
2977:
2974:
2972:
2969:
2967:
2964:
2961:
2958:
2956:
2953:
2951:
2948:
2946:
2943:
2941:
2938:
2936:
2933:
2931:
2928:
2926:
2923:
2921:
2918:
2916:
2913:
2911:
2908:
2906:
2903:
2900:
2897:
2894:
2891:
2888:
2885:
2882:
2879:
2877:
2874:
2873:
2871:
2867:
2864:
2862:
2858:
2855:
2851:
2847:
2843:
2836:
2831:
2829:
2824:
2822:
2817:
2816:
2813:
2799:
2793:
2788:
2784:
2778:
2773:
2769:
2763:
2758:
2754:
2745:
2740:
2738:
2733:
2731:
2726:
2725:
2722:
2713:
2709:
2704:
2699:
2695:
2691:
2687:
2683:
2679:
2674:
2670:
2666:
2661:
2656:
2652:
2648:
2645:(4): 447–53.
2644:
2640:
2636:
2631:
2627:
2623:
2618:
2613:
2609:
2605:
2601:
2597:
2593:
2589:
2585:
2580:
2576:
2572:
2567:
2562:
2558:
2554:
2550:
2545:
2541:
2537:
2532:
2527:
2523:
2519:
2515:
2511:
2507:
2502:
2498:
2494:
2489:
2484:
2480:
2476:
2472:
2467:
2463:
2459:
2454:
2449:
2446:(4): 1793–8.
2445:
2441:
2437:
2432:
2428:
2424:
2419:
2414:
2410:
2406:
2402:
2397:
2393:
2389:
2384:
2379:
2376:(6): 1472–9.
2375:
2371:
2367:
2362:
2358:
2354:
2350:
2346:
2342:
2338:
2333:
2329:
2325:
2320:
2315:
2311:
2307:
2303:
2299:
2295:
2290:
2286:
2282:
2278:
2274:
2269:
2264:
2260:
2256:
2252:
2247:
2243:
2239:
2234:
2229:
2225:
2221:
2217:
2213:
2209:
2204:
2200:
2196:
2192:
2188:
2184:
2180:
2176:
2172:
2167:
2163:
2159:
2154:
2149:
2145:
2141:
2137:
2132:
2128:
2124:
2120:
2116:
2112:
2108:
2105:(7): 652–64.
2104:
2100:
2095:
2091:
2087:
2083:
2079:
2074:
2069:
2066:(7): 1072–7.
2065:
2061:
2057:
2052:
2048:
2044:
2039:
2034:
2030:
2026:
2023:(2): 216–20.
2022:
2018:
2014:
2009:
2005:
2001:
1996:
1991:
1987:
1983:
1979:
1974:
1970:
1966:
1962:
1958:
1953:
1948:
1944:
1940:
1936:
1931:
1930:
1925:
1917:
1913:
1909:
1905:
1902:(4): 237–51.
1901:
1897:
1890:
1887:
1882:
1878:
1874:
1870:
1866:
1862:
1855:
1852:
1847:
1843:
1838:
1833:
1829:
1825:
1821:
1817:
1813:
1806:
1803:
1797:
1793:
1789:
1785:
1781:
1777:
1770:
1767:
1762:
1758:
1753:
1748:
1744:
1740:
1736:
1732:
1728:
1721:
1718:
1713:
1709:
1704:
1699:
1695:
1691:
1688:(1): 747–85.
1687:
1683:
1679:
1672:
1670:
1668:
1664:
1659:
1655:
1650:
1645:
1642:(2): 241–54.
1641:
1637:
1633:
1626:
1623:
1618:
1614:
1609:
1604:
1600:
1596:
1592:
1588:
1584:
1577:
1573:
1567:
1565:
1563:
1559:
1554:
1550:
1545:
1540:
1536:
1532:
1528:
1521:
1519:
1515:
1510:
1506:
1501:
1496:
1491:
1486:
1482:
1478:
1474:
1470:
1466:
1459:
1456:
1451:
1447:
1441:
1438:
1433:
1429:
1423:
1420:
1416:
1412:
1407:
1405:
1403:
1399:
1395:
1391:
1386:
1384:
1382:
1378:
1372:
1370:
1368:
1364:
1360:
1356:
1352:
1348:
1344:
1336:
1334:
1332:
1328:
1324:
1320:
1316:
1312:
1308:
1304:
1300:
1295:
1293:
1289:
1285:
1281:
1277:
1273:
1265:
1263:
1261:
1257:
1253:
1249:
1245:
1241:
1237:
1233:
1229:
1225:
1221:
1217:
1213:
1209:
1205:
1198:Target tissue
1197:
1195:
1192:
1188:
1184:
1180:
1175:
1171:
1166:
1164:
1160:
1156:
1152:
1148:
1144:
1140:
1136:
1132:
1128:
1124:
1120:
1116:
1112:
1108:
1104:
1096:
1088:
1080:
1076:
1068:
1066:
1062:
1060:
1056:
1052:
1044:
1042:
1040:
1037:
1033:
1030:(IL-22) is a
1029:
1017:
1012:
1008:
1004:
1001:
997:
990:
988:
985:
981:
977:
973:
970:
966:
962:
955:
953:
947:
943:
940:
934:
932:
926:
922:
919:
915:
908:
906:
900:
896:
893:
887:
885:
879:
875:
872:
870:RefSeq (mRNA)
868:
861:
860:
855:
851:
848:
842:
841:
836:
832:
829:
827:
823:
816:
815:
810:
806:
803:
797:
796:
791:
787:
784:
782:
778:
771:
770:
765:
761:
758:
752:
751:
746:
742:
739:
737:
733:
730:
727:
725:
722:
718:
715:
711:
707:
700:
696:
691:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
661:
659:
656:
655:
649:
646:
644:
641:
640:
638:
635:
634:
628:
625:
623:
620:
618:
615:
614:
612:
609:
608:
605:
604:Gene ontology
601:
597:
585:
580:
577:
575:
571:
563:
558:
548:mesencephalon
547:
543:
539:
535:
531:
527:
523:
519:
515:
511:
510:
507:
503:
498:
495:
485:
481:
477:
473:
469:
465:
461:
457:
454:muscle tissue
453:
449:
448:
445:
441:
436:
433:
432:
429:
427:
423:
421:
420:
416:
415:
412:
410:
406:
402:
398:
394:
386:
381:
377:
373:
368:
362:10|10 D2
358:
354:
347:
340:
334:
327:
319:
315:
311:
306:
302:
297:
293:
285:
280:
276:
272:
267:
257:
253:
246:
239:
233:
226:
222:
216:
212:
208:
203:
199:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
142:
137:
130:
125:
120:
109:
107:
103:
99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
5216:Interleukins
5177:
5165:M-CSFR/CSF1R
5152:heterodimer)
5138:heterodimer)
5067:Antagonists:
5066:
5038:
5017:
4996:
4956:
4935:
4908:Risankizumab
4889:
4879:
4857:
4850:
4847:
4830:NNC0114-0006
4825:NNC0114-0005
4821:
4806:
4784:
4764:
4743:
4718:
4672:
4637:
4611:
4594:Tralokinumab
4589:Lebrikizumab
4584:Anrukinzumab
4580:
4555:
4529:
4514:
4488:
4462:
4441:
4431:
4390:
4333:Clazakizumab
4324:
4309:
4288:
4272:Benralizumab
4268:
4259:Antagonists:
4258:
4248:
4231:Pascolizumab
4222:
4213:Antagonists:
4212:
4192:
4146:
4115:
4070:
4049:
4029:
4005:Antagonists:
4004:
3975:
3881:
3860:
3829:
3821:By function/
3532:IL28/IFNL2+3
3501:
2797:
2782:
2767:
2685:
2681:
2642:
2638:
2591:
2587:
2556:
2552:
2513:
2509:
2478:
2474:
2443:
2439:
2408:
2404:
2373:
2369:
2340:
2336:
2301:
2297:
2261:(4): 333–5.
2258:
2254:
2215:
2211:
2174:
2170:
2143:
2139:
2102:
2098:
2063:
2060:FEBS Letters
2059:
2020:
2016:
1988:(3): 232–8.
1985:
1981:
1945:(9): 796–8.
1942:
1938:
1899:
1895:
1889:
1864:
1860:
1854:
1819:
1815:
1805:
1779:
1775:
1769:
1734:
1730:
1720:
1685:
1681:
1639:
1635:
1625:
1590:
1586:
1534:
1530:
1472:
1468:
1458:
1449:
1440:
1431:
1422:
1365:signalling.
1353:by specific
1340:
1296:
1269:
1201:
1167:
1075:inflammation
1072:
1063:
1049:IL-22 is an
1048:
1035:
1027:
1026:
949:
928:
902:
881:
857:
838:
812:
793:
767:
748:
728:
723:
424:
417:
383:118,130,943
370:118,125,534
144:External IDs
83:
4918:Ustekinumab
4898:Briakinumab
4890:Antibodies:
4861:Fezakinumab
4858:Antibodies:
4822:Antibodies:
4810:Denenicokin
4785:Antibodies:
4722:Iboctadekin
4701:Vunakizumab
4696:Secukinumab
4686:Perakizumab
4673:Antibodies:
4581:Antibodies:
4538:Ustekinumab
4533:Briakinumab
4530:Antibodies:
4442:Antibodies:
4368:Tocilizumab
4338:Elsilimomab
4325:Antibodies:
4277:Mepolizumab
4269:Antibodies:
4223:Antibodies:
4150:Daniplestim
4119:Basiliximab
4116:Antibodies:
4084:Celmoleukin
4079:Aldesleukin
4043:Lutikizumab
4038:Gevokizumab
4033:Canakinumab
4030:Antibodies:
3749:IL17 family
3490:IL10 family
3409:IL12 family
3261:(grouped by
3249:Interleukin
3172:Lymphotoxin
2750:PDB gallery
1782:: 683–765.
1737:(1): 51–7.
1319:MAP kinases
1274:called the
1123:macrophages
1119:neutrophils
458:granulocyte
282:68,253,604
269:68,248,242
122:Identifiers
5205:Categories
4973:B (IFN-λ3)
4969:A (IFN-λ2)
4903:Guselkumab
4893:Brazikumab
4788:Fletikumab
4691:Remtolumab
4681:Ixekizumab
4676:Brodalumab
4559:Binetrakin
4497:Oprelvekin
4466:Ilodecakin
4445:Enokizumab
4358:Siltuximab
4348:Olokizumab
4282:Reslizumab
4216:Pitrakinra
4196:Binetrakin
4165:Milodistim
4160:Leridistim
4129:Inolimomab
4104:Teceleukin
4023:Isunakinra
3960:modulators
3856:Lymphokine
3694:IL1B/IL1F2
3689:IL1A/IL1F1
3685:IL1 family
3549:Interferon
3537:IL29/IFNL1
1867:: 929–79.
1417:, May 2017
1396:, May 2017
1373:References
1299:interferon
1208:epithelial
1191:hepatocyte
1165:.
536:blastocyst
520:cerebellum
428:(ortholog)
165:HomoloGene
5178:Unsorted:
5039:Agonists:
5018:Agonists:
4997:Agonists:
4957:Agonists:
4936:Agonists:
4880:Agonists:
4848:Agonists:
4807:Agonists:
4765:Agonists:
4737:Tadekinig
4719:Agonists:
4638:Agonists:
4612:Agonists:
4556:Agonists:
4515:Agonists:
4489:Agonists:
4463:Agonists:
4432:Agonists:
4391:Agonists:
4373:Levilimab
4363:Sirukumab
4353:Sarilumab
4310:Agonists:
4249:Agonists:
4226:Dupilumab
4193:Agonists:
4170:Muplestim
4147:Agonists:
4071:Agonists:
3998:Pifonakin
3993:Mobenakin
3976:Agonists:
3734:33/IL1F11
3699:1Ra/IL1F3
3346:IL6 like/
3063:CXCL8/IL8
2861:Chemokine
2853:By family
2846:cytokines
1587:Structure
1579:;
1272:cytokines
1266:Signaling
1187:defensins
1163:psoriasis
1143:defensins
1137:, Reg3β,
1051:α-helical
1045:Structure
952:NP_473420
931:NP_065386
905:NM_054079
884:NM_020525
714:Orthologs
173:GeneCards
5132:IL-22Rα1
5098:instead.
4415:instead.
4343:mAb 1339
4328:ARGX-109
4292:TPI ASM8
4262:YM-90709
4013:Anakinra
4008:AF-12198
3851:Monokine
3380:+non IL
3265:subunit)
3263:receptor
3234:TNFSF13B
3182:TNFC/LTB
3177:TNFB/LTA
2712:20032993
2669:19481975
2626:18978771
2575:19864591
2540:19920355
2497:19830738
2462:20061404
2427:20065946
2392:19449309
2357:19046958
2328:19620772
2285:25601837
2277:19258923
2242:19244159
2199:22534683
2191:20339910
2162:19479869
2127:36646289
2119:19811428
2090:24846059
2082:19285080
2047:19122664
2004:20237496
1969:22906785
1961:19469905
1916:20655797
1881:15032600
1846:20498020
1796:11244051
1761:22906768
1712:25706098
1658:15308104
1636:Immunity
1617:18599299
1553:10875937
1509:10954742
1413:–
1392:–
1359:Dectin-1
1232:pancreas
1204:cytokine
1147:microbes
1081:classes
1069:Function
1000:Wikidata
693:Sources:
474:duodenum
450:appendix
5150:IL-10Rβ
5146:IL-20Rα
5136:IL-20Rβ
5070:IL-36RA
4615:ALT-803
3739:18/IL1G
3481:Type II
3413:IL12RB1
3319:β chain
3273:γ chain
3229:TNFSF13
3224:TNFSF11
3219:TNFSF10
2901:/RANTES
2703:2892169
2660:2755239
2617:3772687
2596:Bibcode
2531:2786807
2319:2719936
2233:2673127
2038:2652837
1837:2882840
1752:4003867
1703:4407497
1608:2637415
1477:Bibcode
1415:Ensembl
1394:Ensembl
1361:and or
1351:ligands
1307:IL-10R2
1303:IL-22R1
1212:stromal
1174:IL-10R2
1170:IL-22R1
1127:stromal
1107:T cells
1059:IL-22R1
1055:IL-10R2
1032:protein
826:UniProt
781:Ensembl
720:Species
699:QuickGO
403:pattern
161:2151139
129:Aliases
5106:Others
5079:Others
5031:IL1RL2
5010:IL1RL1
4747:IL18BP
4018:IL-1RA
3729:IL1F10
3626:IFNA21
3621:IFNA17
3616:IFNA16
3611:IFNA14
3606:IFNA13
3601:IFNA10
3258:Type I
3214:TNFSF9
3209:TNFSF8
3204:TNFSF7
3199:TNFSF6
3189:TNFSF4
3124:CX3CL1
3108:CXCL17
3103:CXCL16
3098:CXCL15
3093:CXCL14
3088:CXCL13
3083:CXCL12
3078:CXCL11
3073:CXCL10
2895:/MIP1β
2889:/MIP1α
2710:
2700:
2667:
2657:
2624:
2614:
2588:Nature
2573:
2538:
2528:
2495:
2460:
2425:
2390:
2355:
2326:
2316:
2283:
2275:
2240:
2230:
2197:
2189:
2160:
2125:
2117:
2088:
2080:
2045:
2035:
2002:
1967:
1959:
1914:
1879:
1844:
1834:
1794:
1759:
1749:
1710:
1700:
1656:
1615:
1605:
1551:
1507:
1497:
1317:, and
1290:, and
1252:breast
1236:kidney
1228:thymus
1079:T-cell
986:search
984:PubMed
859:Q9JJY8
840:Q9GZX6
769:116849
736:Entrez
574:BioGPS
532:zygote
512:morula
482:tonsil
153:605330
4989:IL-31
4949:IL-28
4928:IL-27
4872:IL-23
4840:IL-22
4799:IL-21
4757:IL-20
4711:IL-18
4630:IL-17
4604:IL-15
4548:IL-13
4507:IL-12
4481:IL-11
4455:IL-10
3791:KITLG
3779:Other
3765:IL17A
3724:IL1F9
3719:IL1F8
3714:IL1F7
3709:IL1F6
3704:IL1F5
3641:IFNW1
3631:IFNB1
3596:IFNA8
3591:IFNA7
3586:IFNA6
3581:IFNA5
3576:IFNA4
3571:IFNA2
3566:IFNA1
3445:Other
3348:gp130
3337:GMCSF
3117:CX3CL
3068:CXCL9
3058:CXCL7
3053:CXCL6
3048:CXCL5
3043:CXCL4
3038:CXCL3
3033:CXCL2
3027:CXCL1
3011:CCL28
3006:CCL27
3001:CCL26
2996:CCL25
2991:CCL24
2986:CCL23
2981:CCL22
2976:CCL21
2971:CCL20
2966:CCL19
2960:CCL18
2955:CCL17
2950:CCL16
2945:CCL15
2940:CCL14
2935:CCL13
2930:CCL12
2925:CCL11
2883:/MCP1
2281:S2CID
2212:Blood
2195:S2CID
2123:S2CID
2086:S2CID
1965:S2CID
1500:27764
1367:IL-1β
1343:IL-23
1331:IL-24
1327:IL-20
1323:STAT3
1292:IL-26
1288:IL-24
1284:IL-20
1280:IL-19
1276:IL-10
1248:heart
1216:liver
1183:S100s
1153:like
1139:Reg3γ
750:50616
729:Mouse
724:Human
695:Amigo
470:thigh
426:Mouse
419:Human
366:Start
301:Mouse
265:Start
261:12q15
198:Human
5096:here
5094:See
4424:IL-9
4413:here
4404:IL-8
4383:IL-7
4302:IL-6
4241:IL-5
4185:IL-4
4139:IL-3
4063:IL-2
3968:IL-1
3911:IL13
3906:IL10
3875:TNFβ
3870:IFNγ
3842:TNFA
3823:cell
3803:SPP1
3761:IL25
3757:IL17
3659:IFNG
3636:IFNK
3522:IL26
3517:IL24
3512:IL20
3507:IL19
3502:IL22
3498:IL10
3467:IL34
3462:IL32
3457:IL16
3452:IL14
3436:IL35
3431:IL27
3426:IL23
3421:IL12
3397:CTF1
3392:CNTF
3376:IL31
3371:IL30
3366:IL27
3361:IL11
3309:IL21
3294:IL13
3285:IL15
3167:TNFA
3145:XCL2
3140:XCL1
3020:CXCL
2920:CCL9
2915:CCL8
2910:CCL7
2905:CCL6
2899:CCL5
2893:CCL4
2887:CCL3
2881:CCL2
2876:CCL1
2798:1ykb
2783:3dlq
2768:1m4r
2708:PMID
2665:PMID
2622:PMID
2571:PMID
2536:PMID
2493:PMID
2458:PMID
2423:PMID
2388:PMID
2353:PMID
2324:PMID
2273:PMID
2238:PMID
2187:PMID
2158:PMID
2115:PMID
2078:PMID
2043:PMID
2000:PMID
1957:PMID
1912:PMID
1877:PMID
1842:PMID
1792:PMID
1757:PMID
1708:PMID
1654:PMID
1613:PMID
1576:3DGC
1549:PMID
1505:PMID
1363:NOD2
1329:and
1315:Tyk2
1311:JAK1
1305:and
1258:and
1224:skin
1220:lung
1210:and
1185:and
1172:and
1161:and
1141:and
1135:S100
1129:and
1121:and
1115:ILC3
1097:and
1057:and
1039:gene
1036:IL22
409:Bgee
357:Band
318:Chr.
256:Band
215:Chr.
177:IL22
169:9669
149:OMIM
136:IL22
106:3Q1S
102:3G9V
98:3DLQ
94:3DGC
90:1YKB
86:1M4R
67:RCSB
64:PDBe
33:IL22
5122:CD4
5087:JAK
3901:IL6
3896:IL5
3891:IL4
3837:IL1
3808:MIF
3387:LIF
3382:OSM
3356:IL6
3332:IL5
3327:IL3
3304:IL9
3299:IL7
3290:IL4
3281:IL2
3239:EDA
3159:TNF
3133:XCL
3029:/KC
2869:CCL
2698:PMC
2690:doi
2686:130
2655:PMC
2647:doi
2612:PMC
2604:doi
2592:457
2561:doi
2557:183
2526:PMC
2518:doi
2514:119
2483:doi
2448:doi
2444:184
2413:doi
2378:doi
2345:doi
2341:401
2314:PMC
2306:doi
2302:119
2263:doi
2228:PMC
2220:doi
2216:113
2179:doi
2148:doi
2107:doi
2068:doi
2064:583
2033:PMC
2025:doi
1990:doi
1947:doi
1904:doi
1869:doi
1832:PMC
1824:doi
1820:207
1784:doi
1747:PMC
1739:doi
1698:PMC
1690:doi
1644:doi
1603:PMC
1595:doi
1572:PDB
1539:doi
1535:275
1495:PMC
1485:doi
1256:eye
1111:NKT
582:n/a
379:End
278:End
181:OMA
157:MGI
57:PDB
5207::
5052:,
5048:,
4971:,
4663:,
4659:,
4655:,
4651:,
4647:,
3985:,
3687::
3651:II
2844::
2706:.
2696:.
2684:.
2680:.
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2641:.
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2084:.
2076:.
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2041:.
2031:.
2021:41
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2015:.
1998:.
1986:11
1984:.
1980:.
1963:.
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1943:18
1941:.
1937:.
1910:.
1900:21
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1103:17
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372:bp
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271:bp
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5054:γ
5050:β
5046:α
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4967:(
4667:)
4665:F
4657:D
4653:C
4649:B
4645:A
4643:(
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