363:
200:
42:
726:
According to an immunology textbook: "IL-2 is particularly important historically, as it is the first type I cytokine that was cloned, the first type I cytokine for which a receptor component was cloned, and was the first short-chain type I cytokine whose receptor structure was solved. Many general
727:
principles have been derived from studies of this cytokine, including its being the first cytokine demonstrated to act in a growth factor–like fashion through specific high-affinity receptors, analogous to the growth factors being studied by endocrinologists and biochemists".
694:, thus helping the body fight off infections. Through their role in the development of T cell immunologic memory, which depends upon the expansion of the number and function of antigen-selected T cell clones, they also have a key role in enduring
573:
The three receptor chains are expressed separately and differently on various cell types and can assemble in different combinations and orders to generate low, intermediate, and high affinity IL-2 receptors.
651:
are rapidly degraded, but IL-2Rα is recycled to the cell surface. Thus, the concentration of IL-2 and its receptor available determines the tempo, magnitude and extent of T cell immune responses.
4124:
2948:
1662:
2087:
2938:
1785:
960:
Metz A, Ciglia E, Gohlke H (2012). "Modulating protein-protein interactions: from structural determinants of binding to druggability prediction to application".
632:. These enzymes are activated by IL-2 binding to the external domains of the IL-2R. As a consequence, three intracellular signaling pathways are initiated, the
4117:
393:
230:
72:
1072:
2918:
682:, which kill off other T cells that are primed to attack normal healthy cells in the body. IL-2/IL2R also promotes the differentiation of T cells into
545:
IL-2 binds to the IL-2 receptor, which has three forms, generated by different combinations of three different proteins, often referred to as "chains":
3780:
2104:
2080:
1462:
577:
The α chain binds IL-2 with low affinity, the combination of β and γ together form a complex that binds IL-2 with intermediate affinity, primarily on
4110:
2033:
3511:
1751:
1747:
1730:
763:
Wang X, Rickert M, Garcia KC (November 2005). "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors".
5322:
4589:
3499:
3277:
1864:
1839:
1703:
5392:
5387:
5326:
5312:
5272:
3563:
3558:
3504:
3284:
2065:
1868:
1843:
1694:
647:
Once IL-2 binds to the high affinity receptor, the complex is rapidly internalized and has only a short time to signal. IL-2, IL-2Rβ, and γ
5397:
5341:
3017:
2943:
2073:
2021:
1720:
1655:
5407:
4046:
4041:
4036:
4031:
2958:
1715:
417:
254:
96:
5402:
5246:
4194:
4011:
826:
3247:
1594:
1299:
1291:
1065:
561:, or CD132); these subunits are also parts of receptors for other cytokines. The β and γ chains of the IL-2R are members of the
405:
353:
242:
84:
3815:
3309:
2995:
1942:
1240:
398:
235:
77:
3454:
2990:
1937:
1885:
1276:
593:. The intermediate and high affinity receptor forms are functional and cause changes in the cell when IL-2 binds to them.
5207:
5186:
3951:
3423:
3418:
3363:
3097:
2546:
1189:
1151:
1146:
857:"IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation"
3645:
3368:
1194:
2963:
1906:
1902:
1058:
600:. The structure supports a model wherein IL-2 initially binds to the α chain, then the β is recruited, and finally γ.
1607:
624:(JAK1), that is capable of adding phosphate groups to molecules. Similarly the gamma chain complexes with another
3675:
2100:
1922:
1538:
1094:
596:
The structure of the stable complex formed when IL-2 binds to the high affinity receptor has been determined using
2541:
1898:
1822:
1521:
1307:
637:
3725:
2620:
2052:
2016:
1547:
1044:
675:
562:
5165:
5125:
5104:
5048:
5016:
4975:
4933:
4887:
4806:
4780:
4724:
4683:
4657:
4631:
4285:
3689:
1971:
1949:
1873:
1860:
1847:
1835:
1803:
1790:
1780:
1756:
1743:
1699:
1690:
1617:
1590:
1581:
1176:
995:
Hardinger KL, Brennan DC, Klein CL (July 2013). "Selection of induction therapy in kidney transplantation".
4740:
585:; and all three receptor chains form a complex that binds IL-2 with high affinity (Kd ~ 10 M) on activated
4600:
4580:
4559:
4478:
4417:
4361:
4315:
4239:
4144:
3032:
3027:
3022:
3012:
2319:
2247:
2008:
1932:
1685:
1651:
1642:
1612:
1603:
1586:
1184:
1104:
817:
Leonard WJ (2008). "Chapter 23: Type I Cytokines and
Interferons and Their Receptors.". In Paul WE (ed.).
695:
410:
247:
89:
2376:
2294:
1710:
597:
518:
300:
142:
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5362:
5145:
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1830:
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463:
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4468:
4438:
4184:
1081:
1012:
977:
942:
886:
822:
788:
753:
655:
616:. The alpha chain does not participate in signaling, but the beta chain is complexed with an
5357:
3820:
3553:
3474:
3037:
2230:
2156:
1996:
1799:
1672:
1513:
1505:
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1004:
969:
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295:
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137:
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735:
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166:
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4908:
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687:
621:
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362:
199:
41:
17:
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4270:
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2183:
1775:
609:
534:
800:
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4509:
4448:
4407:
3991:
3299:
3289:
2820:
2786:
1963:
1331:
1024:
913:"Interleukin-2 receptor signaling: at the interface between tolerance and immunity"
629:
522:
4102:
928:
434:
271:
113:
5094:
5074:
5037:
4872:
4862:
4714:
4709:
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4514:
4453:
4295:
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4214:
4209:
4001:
3650:
3428:
3403:
3102:
2724:
2650:
2124:
1156:
1131:
821:(6th ed.). Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins.
707:
497:
334:
176:
973:
5079:
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4857:
4852:
4673:
4534:
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4305:
4300:
4229:
3931:
3655:
3336:
3077:
2953:
2586:
2581:
2576:
2431:
2215:
872:
711:
526:
441:
278:
120:
4549:
4539:
4529:
4402:
3770:
3765:
3760:
3750:
3745:
3740:
3735:
1446:
1438:
1430:
784:
654:
IL-2 and its receptor have key roles in key functions of the immune system,
1016:
981:
946:
890:
792:
4189:
4076:
3976:
3790:
3775:
2978:
2973:
2881:
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283:
125:
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1855:
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691:
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1008:
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2536:
2406:
2396:
2359:
2354:
2272:
2267:
1991:
1986:
1981:
1976:
1953:
1893:
1889:
1629:
1262:
1050:
667:
617:
429:
266:
108:
553:(also called IL-2Rβ, or CD122), and γ (gamma) (also called IL-2Rγ, γ
5230:
5226:
5222:
4841:
4837:
4821:
4091:
4066:
3986:
3981:
3971:
3961:
3946:
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3319:
3262:
3257:
3252:
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3230:
3168:
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3148:
3138:
3117:
3107:
3072:
3067:
3062:
3057:
3052:
3007:
3002:
2968:
2933:
2928:
2923:
2913:
2901:
2896:
2876:
2871:
2866:
2861:
2815:
2707:
2702:
2521:
2505:
2498:
2493:
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2483:
2478:
2473:
2448:
2426:
2421:
2314:
2240:
2235:
2225:
2026:
1646:
1577:
1573:
1363:
1315:
1257:
1221:
1216:
1211:
1206:
1201:
1166:
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1116:
550:
546:
378:
349:
215:
191:
57:
33:
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4081:
4071:
4061:
4056:
4051:
4006:
3996:
3956:
3885:
3855:
3850:
3845:
3840:
3835:
3830:
3785:
3755:
3660:
3628:
3623:
3603:
3593:
3588:
3573:
3568:
3469:
3464:
3433:
3413:
3408:
3398:
3393:
3272:
3225:
3185:
2840:
2835:
2830:
2825:
2810:
2801:
2796:
2791:
2776:
2734:
2729:
2719:
2714:
2697:
2692:
2687:
2682:
2677:
2672:
2667:
2662:
2657:
2593:
2566:
2561:
2556:
2531:
2526:
2463:
2458:
2453:
2443:
2438:
2391:
2386:
2381:
2371:
2366:
2349:
2344:
2339:
2329:
2324:
2309:
2304:
2299:
2289:
2284:
2279:
2262:
2257:
2252:
2203:
2171:
2166:
2161:
2144:
2139:
2134:
2129:
1414:
1355:
1347:
1339:
1250:
1161:
1141:
1136:
1121:
1112:
422:
259:
101:
4106:
2069:
1054:
5298:
3598:
2210:
2198:
2193:
2188:
2178:
2151:
2119:
569:
Structure-activity relationships of the IL-2/IL-2R interaction
714:
are used in conjunction with other drugs to prevent
5282:
5262:
5255:
5206:
5185:
5164:
5124:
5103:
5047:
5015:
4974:
4932:
4886:
4805:
4779:
4723:
4682:
4656:
4630:
4599:
4579:
4558:
4477:
4416:
4360:
4314:
4238:
4143:
3904:
3698:
3447:
3131:
2854:
2514:
2112:
2007:
1962:
1921:
1821:
1767:
1729:
1671:
1628:
1555:
1546:
1537:
1498:
1375:
1284:
1275:
1230:
1175:
1103:
1088:
614:
delivering biochemical signals to the cell interior
493:
483:
478:
457:
452:
440:
428:
416:
404:
392:
384:
374:
369:
348:
330:
320:
315:
294:
289:
277:
265:
253:
241:
229:
221:
211:
206:
190:
172:
162:
157:
136:
131:
119:
107:
95:
83:
71:
63:
53:
48:
32:
690:when the initial T cells is also stimulated by an
27:Lymphocyte receptor specific for Interleukin-2
4118:
2081:
1066:
8:
906:
904:
902:
900:
549:(also called IL-2Rα, CD25, or Tac antigen),
521:protein expressed on the surface of certain
855:Liao W, Lin JX, Leonard WJ (October 2011).
850:
848:
846:
844:
842:
840:
838:
706:Drugs that inhibit IL-2 receptors, such as
5259:
4125:
4111:
4103:
2088:
2074:
2066:
1552:
1543:
1281:
1100:
1073:
1059:
1051:
475:
361:
312:
198:
154:
40:
2105:list of human clusters of differentiation
1043:at the U.S. National Library of Medicine
936:
880:
812:
810:
5290:Interleukin 14 (taxilin alpha, HMW-BCGF)
662:, primarily via their direct effects on
608:The three IL-2 receptor chains span the
745:
4588:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
345:
187:
29:
670:, where T cells mature, they prevent
7:
350:interleukin 2 receptor, gamma chain
34:interleukin 2 receptor, alpha chain
911:Malek TR, Castro I (August 2010).
612:and extend into the cell, thereby
192:interleukin 2 receptor, beta chain
25:
678:of certain immature T cells into
354:severe combined immunodeficiency
5116:Interleukin 27 (interleukin 30)
716:immune rejection of transplants
529:, that binds and responds to a
1:
962:Current Pharmaceutical Design
861:Current Opinion in Immunology
5393:Genes on human chromosome 22
5388:Genes on human chromosome 10
929:10.1016/j.immuni.2010.08.004
5398:Genes on human chromosome X
4466:Antisense oligonucleotides:
2101:clusters of differentiation
5424:
5408:Integral membrane proteins
974:10.2174/138161212802651553
5403:Type I cytokine receptors
873:10.1016/j.coi.2011.08.003
638:Phosphoinositide 3-kinase
474:
360:
311:
197:
153:
39:
1045:Medical Subject Headings
997:Transplant International
640:(PI3K) pathway, and the
563:type I cytokine receptor
5156:Interleukin-29 (IFN-λ1)
4301:Daclizumab (dacliximab)
4286:Tucotuzumab celmoleukin
1041:Interleukin-2+Receptors
785:10.1126/science.1117893
5137:Interferon λ4 (IFN-λ4)
4230:Rilonacept (IL-1 Trap)
2009:Enzyme-linked receptor
819:Fundamental Immunology
696:cell-mediated immunity
511:interleukin-2 receptor
18:Interleukin-2 receptor
5060:Interleukin 23 (SGRF)
4741:Cintredekin besudotox
4669:Interleukin 11 (AGIF)
4648:Interleukin 10 (CSIF)
1831:Interleukin receptors
1739:Interleukin receptors
1681:Interleukin receptors
1638:Interleukin receptors
1565:Interleukin receptors
702:Clinical implications
598:X-ray crystallography
4134:Interleukin receptor
1881:Interferon receptors
4266:Denileukin diftitox
777:2005Sci...310.1159W
672:autoimmune diseases
388:SCIDX1, IMD4, CD132
4838:E (interleukin 25)
1090:Chemokine receptor
1082:Cytokine receptors
680:regulatory T cells
634:MAP kinase pathway
591:regulatory T cells
559:common gamma chain
5375:
5374:
5371:
5370:
5340:(signals through
5321:(signals through
5307:(signals through
5297:(signals through
4921:Binding proteins:
4251:Adargileukin alfa
4100:
4099:
2063:
2062:
1917:
1916:
1817:
1816:
1533:
1532:
1271:
1270:
1009:10.1111/tri.12043
771:(5751): 1159–63.
674:by promoting the
507:
506:
503:
502:
344:
343:
340:
339:
186:
185:
182:
181:
16:(Redirected from
5415:
5363:Efineptakin alfa
5358:Efavaleukin alfa
5260:
4227:Decoy receptors:
4127:
4120:
4113:
4104:
2090:
2083:
2076:
2067:
1800:hormone receptor
1553:
1544:
1282:
1101:
1075:
1068:
1061:
1052:
1029:
1028:
992:
986:
985:
957:
951:
950:
940:
908:
895:
894:
884:
852:
833:
832:
814:
805:
804:
760:
750:
684:effector T cells
642:JAK-STAT pathway
476:
365:
346:
313:
202:
188:
155:
44:
30:
21:
5423:
5422:
5418:
5417:
5416:
5414:
5413:
5412:
5378:
5377:
5376:
5367:
5278:
5251:
5202:
5181:
5160:
5120:
5099:
5043:
5040:(against IL-22)
5011:
4970:
4967:(against IL-20)
4928:
4882:
4801:
4775:
4719:
4678:
4652:
4626:
4595:
4575:
4554:
4473:
4412:
4356:
4310:
4234:
4139:
4131:
4101:
4096:
3900:
3694:
3443:
3127:
2850:
2510:
2108:
2094:
2064:
2059:
2003:
1958:
1913:
1813:
1763:
1725:
1667:
1624:
1529:
1494:
1423:Osteoprotegerin
1371:
1267:
1226:
1171:
1092:
1084:
1079:
1037:
1032:
994:
993:
989:
968:(30): 4630–47.
959:
958:
954:
910:
909:
898:
854:
853:
836:
829:
816:
815:
808:
762:
752:
751:
747:
743:
736:CD25 deficiency
733:
724:
704:
676:differentiation
650:
626:tyrosine kinase
606:
571:
556:
543:
28:
23:
22:
15:
12:
11:
5:
5421:
5419:
5411:
5410:
5405:
5400:
5395:
5390:
5380:
5379:
5373:
5372:
5369:
5368:
5366:
5365:
5360:
5351:
5350:
5348:Interleukin 35
5345:
5338:Interleukin 34
5335:
5333:Interleukin 32
5330:
5319:Interleukin 26
5316:
5305:Interleukin 24
5302:
5295:Interleukin 16
5292:
5286:
5284:
5280:
5279:
5277:
5276:
5268:
5266:
5257:
5253:
5252:
5250:
5249:
5240:
5239:
5237:Interleukin 38
5234:
5219:Interleukin 36
5212:
5210:
5204:
5203:
5201:
5200:
5198:Interleukin 33
5191:
5189:
5183:
5182:
5180:
5179:
5177:Interleukin 31
5170:
5168:
5162:
5161:
5159:
5158:
5153:
5142:Interleukin 28
5139:
5130:
5128:
5122:
5121:
5119:
5118:
5109:
5107:
5101:
5100:
5098:
5097:
5092:
5087:
5082:
5077:
5072:
5063:
5062:
5053:
5051:
5045:
5044:
5042:
5041:
5031:
5030:
5028:Interleukin 22
5021:
5019:
5013:
5012:
5010:
5009:
5004:
4995:
4994:
4992:Interleukin 21
4989:
4980:
4978:
4972:
4971:
4969:
4968:
4958:
4957:
4955:Interleukin 24
4952:
4950:Interleukin 20
4947:
4945:Interleukin 19
4938:
4936:
4930:
4929:
4927:
4926:
4917:
4916:
4911:
4909:Interleukin 37
4906:
4904:Interleukin 18
4901:
4892:
4890:
4884:
4883:
4881:
4880:
4875:
4870:
4865:
4860:
4855:
4846:
4845:
4818:Interleukin 17
4811:
4809:
4803:
4802:
4800:
4799:
4797:Interleukin 15
4794:
4785:
4783:
4777:
4776:
4774:
4773:
4768:
4763:
4754:
4753:
4751:Interleukin 13
4748:
4743:
4738:
4729:
4727:
4721:
4720:
4718:
4717:
4712:
4703:
4702:
4700:Interleukin 12
4697:
4688:
4686:
4680:
4679:
4677:
4676:
4671:
4662:
4660:
4654:
4653:
4651:
4650:
4645:
4636:
4634:
4628:
4627:
4625:
4624:
4615:
4614:
4605:
4603:
4597:
4596:
4594:
4593:
4585:
4583:
4577:
4576:
4574:
4573:
4564:
4562:
4556:
4555:
4553:
4552:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4512:
4507:
4498:
4497:
4492:
4483:
4481:
4475:
4474:
4472:
4471:
4462:
4461:
4456:
4451:
4442:
4441:
4432:
4431:
4422:
4420:
4414:
4413:
4411:
4410:
4405:
4396:
4395:
4386:
4385:
4383:Interleukin 13
4380:
4375:
4366:
4364:
4358:
4357:
4355:
4354:
4352:Promegapoietin
4349:
4344:
4339:
4334:
4329:
4320:
4318:
4312:
4311:
4309:
4308:
4303:
4298:
4289:
4288:
4283:
4278:
4276:Pegaldesleukin
4273:
4268:
4263:
4258:
4253:
4244:
4242:
4236:
4235:
4233:
4232:
4223:
4222:
4217:
4212:
4203:
4202:
4197:
4192:
4187:
4178:
4177:
4172:
4167:
4149:
4147:
4141:
4140:
4132:
4130:
4129:
4122:
4115:
4107:
4098:
4097:
4095:
4094:
4089:
4084:
4079:
4074:
4069:
4064:
4059:
4054:
4049:
4044:
4039:
4034:
4029:
4024:
4019:
4014:
4009:
4004:
3999:
3994:
3989:
3984:
3979:
3974:
3969:
3964:
3959:
3954:
3949:
3944:
3939:
3934:
3929:
3924:
3919:
3914:
3908:
3906:
3902:
3901:
3899:
3898:
3893:
3888:
3883:
3878:
3873:
3868:
3863:
3858:
3853:
3848:
3843:
3838:
3833:
3828:
3823:
3818:
3813:
3808:
3803:
3798:
3793:
3788:
3783:
3778:
3773:
3768:
3763:
3758:
3753:
3748:
3743:
3738:
3733:
3728:
3723:
3718:
3713:
3708:
3702:
3700:
3696:
3695:
3693:
3692:
3687:
3678:
3673:
3668:
3663:
3658:
3653:
3648:
3643:
3638:
3633:
3632:
3631:
3626:
3616:
3611:
3606:
3601:
3596:
3591:
3586:
3581:
3576:
3571:
3566:
3561:
3556:
3551:
3545:
3536:
3531:
3530:
3529:
3524:
3514:
3509:
3508:
3507:
3502:
3492:
3487:
3482:
3477:
3472:
3467:
3462:
3457:
3451:
3449:
3445:
3444:
3442:
3441:
3436:
3431:
3426:
3421:
3416:
3411:
3406:
3401:
3396:
3391:
3386:
3381:
3376:
3371:
3366:
3361:
3356:
3355:
3354:
3349:
3339:
3334:
3329:
3324:
3323:
3322:
3317:
3312:
3302:
3297:
3292:
3287:
3282:
3281:
3280:
3275:
3265:
3260:
3255:
3250:
3245:
3240:
3235:
3234:
3233:
3228:
3218:
3212:
3207:
3202:
3197:
3188:
3183:
3182:
3181:
3176:
3171:
3161:
3156:
3151:
3146:
3141:
3135:
3133:
3129:
3128:
3126:
3125:
3120:
3115:
3110:
3105:
3100:
3095:
3090:
3085:
3080:
3075:
3070:
3065:
3060:
3055:
3050:
3045:
3040:
3035:
3030:
3025:
3020:
3015:
3010:
3005:
3000:
2999:
2998:
2993:
2983:
2982:
2981:
2976:
2966:
2961:
2956:
2951:
2946:
2941:
2936:
2931:
2926:
2921:
2916:
2911:
2906:
2905:
2904:
2899:
2889:
2884:
2879:
2874:
2869:
2864:
2858:
2856:
2852:
2851:
2849:
2848:
2843:
2838:
2833:
2828:
2823:
2818:
2813:
2808:
2799:
2794:
2789:
2784:
2779:
2774:
2773:
2772:
2767:
2762:
2757:
2752:
2747:
2737:
2732:
2727:
2722:
2717:
2712:
2711:
2710:
2705:
2695:
2690:
2685:
2680:
2675:
2670:
2665:
2660:
2655:
2654:
2653:
2648:
2643:
2638:
2633:
2628:
2618:
2617:
2616:
2611:
2606:
2596:
2591:
2590:
2589:
2584:
2579:
2569:
2564:
2559:
2554:
2549:
2544:
2539:
2534:
2529:
2524:
2518:
2516:
2512:
2511:
2509:
2508:
2503:
2502:
2501:
2496:
2491:
2486:
2481:
2476:
2466:
2461:
2456:
2451:
2446:
2441:
2436:
2435:
2434:
2429:
2424:
2419:
2409:
2404:
2399:
2394:
2389:
2384:
2379:
2374:
2369:
2364:
2363:
2362:
2357:
2347:
2342:
2337:
2332:
2327:
2322:
2317:
2312:
2307:
2302:
2297:
2292:
2287:
2282:
2277:
2276:
2275:
2270:
2260:
2255:
2250:
2245:
2244:
2243:
2238:
2233:
2228:
2218:
2213:
2208:
2207:
2206:
2196:
2191:
2186:
2181:
2176:
2175:
2174:
2169:
2164:
2154:
2149:
2148:
2147:
2142:
2137:
2132:
2127:
2116:
2114:
2110:
2109:
2095:
2093:
2092:
2085:
2078:
2070:
2061:
2060:
2058:
2057:
2056:
2055:
2050:
2045:
2031:
2030:
2029:
2024:
2013:
2011:
2005:
2004:
2002:
2001:
2000:
1999:
1994:
1989:
1984:
1979:
1968:
1966:
1960:
1959:
1957:
1956:
1947:
1946:
1945:
1940:
1930:
1927:
1925:
1923:Ig superfamily
1919:
1918:
1915:
1914:
1912:
1911:
1910:
1909:
1896:
1878:
1877:
1876:
1871:
1858:
1827:
1825:
1819:
1818:
1815:
1814:
1812:
1811:
1806:
1796:
1795:
1794:
1793:
1791:Thrombopoietin
1788:
1783:
1771:
1769:
1765:
1764:
1762:
1761:
1760:
1759:
1754:
1735:
1733:
1727:
1726:
1724:
1723:
1718:
1713:
1708:
1707:
1706:
1697:
1688:
1677:
1675:
1669:
1668:
1666:
1665:
1660:
1659:
1658:
1649:
1634:
1632:
1626:
1625:
1623:
1622:
1621:
1620:
1615:
1610:
1601:
1584:
1561:
1559:
1550:
1541:
1535:
1534:
1531:
1530:
1528:
1527:
1519:
1511:
1502:
1500:
1496:
1495:
1493:
1492:
1484:
1476:
1468:
1460:
1452:
1444:
1436:
1428:
1420:
1412:
1404:
1396:
1388:
1379:
1377:
1373:
1372:
1370:
1369:
1361:
1353:
1345:
1337:
1329:
1321:
1313:
1305:
1297:
1288:
1286:
1279:
1273:
1272:
1269:
1268:
1266:
1265:
1260:
1255:
1254:
1253:
1245:
1244:
1243:
1234:
1232:
1228:
1227:
1225:
1224:
1219:
1214:
1209:
1204:
1199:
1198:
1197:
1192:
1181:
1179:
1173:
1172:
1170:
1169:
1164:
1159:
1154:
1149:
1144:
1139:
1134:
1129:
1124:
1119:
1109:
1107:
1098:
1086:
1085:
1080:
1078:
1077:
1070:
1063:
1055:
1049:
1048:
1036:
1035:External links
1033:
1031:
1030:
987:
952:
896:
867:(5): 598–604.
834:
827:
806:
744:
742:
739:
732:
729:
723:
720:
703:
700:
688:memory T cells
648:
622:Janus kinase 1
605:
602:
579:memory T cells
570:
567:
554:
542:
539:
519:heterotrimeric
505:
504:
501:
500:
495:
491:
490:
485:
481:
480:
472:
471:
461:
455:
454:
450:
449:
444:
438:
437:
432:
426:
425:
420:
414:
413:
408:
402:
401:
396:
390:
389:
386:
382:
381:
376:
372:
371:
367:
366:
358:
357:
342:
341:
338:
337:
332:
328:
327:
322:
318:
317:
309:
308:
298:
292:
291:
287:
286:
281:
275:
274:
269:
263:
262:
257:
251:
250:
245:
239:
238:
233:
227:
226:
223:
219:
218:
213:
209:
208:
204:
203:
195:
194:
184:
183:
180:
179:
174:
170:
169:
164:
160:
159:
151:
150:
140:
134:
133:
129:
128:
123:
117:
116:
111:
105:
104:
99:
93:
92:
87:
81:
80:
75:
69:
68:
65:
61:
60:
55:
51:
50:
46:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5420:
5409:
5406:
5404:
5401:
5399:
5396:
5394:
5391:
5389:
5386:
5385:
5383:
5364:
5361:
5359:
5356:
5353:
5352:
5349:
5346:
5343:
5339:
5336:
5334:
5331:
5328:
5324:
5320:
5317:
5314:
5310:
5306:
5303:
5300:
5296:
5293:
5291:
5288:
5287:
5285:
5281:
5274:
5270:
5269:
5267:
5265:
5261:
5258:
5254:
5248:
5245:
5242:
5241:
5238:
5235:
5232:
5228:
5224:
5220:
5217:
5214:
5213:
5211:
5209:
5205:
5199:
5196:
5193:
5192:
5190:
5188:
5184:
5178:
5175:
5172:
5171:
5169:
5167:
5163:
5157:
5154:
5151:
5147:
5143:
5140:
5138:
5135:
5132:
5131:
5129:
5127:
5123:
5117:
5114:
5111:
5110:
5108:
5106:
5102:
5096:
5093:
5091:
5090:Tildrakizumab
5088:
5086:
5083:
5081:
5078:
5076:
5073:
5071:
5068:
5065:
5064:
5061:
5058:
5055:
5054:
5052:
5050:
5046:
5039:
5036:
5033:
5032:
5029:
5026:
5023:
5022:
5020:
5018:
5014:
5008:
5005:
5003:
5000:
4997:
4996:
4993:
4990:
4988:
4985:
4982:
4981:
4979:
4977:
4973:
4966:
4963:
4960:
4959:
4956:
4953:
4951:
4948:
4946:
4943:
4940:
4939:
4937:
4935:
4931:
4925:
4922:
4919:
4918:
4915:
4912:
4910:
4907:
4905:
4902:
4900:
4897:
4894:
4893:
4891:
4889:
4885:
4879:
4876:
4874:
4871:
4869:
4866:
4864:
4861:
4859:
4856:
4854:
4851:
4848:
4847:
4843:
4839:
4835:
4831:
4827:
4823:
4819:
4816:
4813:
4812:
4810:
4808:
4804:
4798:
4795:
4793:
4790:
4787:
4786:
4784:
4782:
4778:
4772:
4769:
4767:
4764:
4762:
4759:
4756:
4755:
4752:
4749:
4747:
4746:Interleukin 4
4744:
4742:
4739:
4737:
4734:
4731:
4730:
4728:
4726:
4722:
4716:
4713:
4711:
4708:
4705:
4704:
4701:
4698:
4696:
4695:Edodekin alfa
4693:
4690:
4689:
4687:
4685:
4681:
4675:
4672:
4670:
4667:
4664:
4663:
4661:
4659:
4655:
4649:
4646:
4644:
4641:
4638:
4637:
4635:
4633:
4629:
4623:
4620:
4617:
4616:
4613:
4612:Interleukin 9
4610:
4607:
4606:
4604:
4602:
4598:
4591:
4587:
4586:
4584:
4582:
4578:
4572:
4571:Interleukin 7
4569:
4566:
4565:
4563:
4561:
4557:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4516:
4513:
4511:
4508:
4506:
4503:
4500:
4499:
4496:
4495:Interleukin 6
4493:
4491:
4490:Atexakin alfa
4488:
4485:
4484:
4482:
4480:
4476:
4470:
4467:
4464:
4463:
4460:
4457:
4455:
4452:
4450:
4447:
4444:
4443:
4440:
4437:
4434:
4433:
4430:
4429:Interleukin 5
4427:
4424:
4423:
4421:
4419:
4415:
4409:
4406:
4404:
4401:
4398:
4397:
4394:
4391:
4388:
4387:
4384:
4381:
4379:
4378:Interleukin 4
4376:
4374:
4371:
4368:
4367:
4365:
4363:
4359:
4353:
4350:
4348:
4345:
4343:
4340:
4338:
4335:
4333:
4332:Interleukin 3
4330:
4328:
4325:
4322:
4321:
4319:
4317:
4313:
4307:
4304:
4302:
4299:
4297:
4294:
4291:
4290:
4287:
4284:
4282:
4279:
4277:
4274:
4272:
4271:Interleukin 2
4269:
4267:
4264:
4262:
4259:
4257:
4254:
4252:
4249:
4246:
4245:
4243:
4241:
4237:
4231:
4228:
4225:
4224:
4221:
4218:
4216:
4213:
4211:
4208:
4205:
4204:
4201:
4198:
4196:
4193:
4191:
4188:
4186:
4183:
4180:
4179:
4176:
4173:
4171:
4168:
4165:
4161:
4157:
4156:Interleukin 1
4154:
4151:
4150:
4148:
4146:
4142:
4138:
4135:
4128:
4123:
4121:
4116:
4114:
4109:
4108:
4105:
4093:
4090:
4088:
4085:
4083:
4080:
4078:
4075:
4073:
4070:
4068:
4065:
4063:
4060:
4058:
4055:
4053:
4050:
4048:
4045:
4043:
4040:
4038:
4035:
4033:
4030:
4028:
4025:
4023:
4020:
4018:
4015:
4013:
4010:
4008:
4005:
4003:
4000:
3998:
3995:
3993:
3990:
3988:
3985:
3983:
3980:
3978:
3975:
3973:
3970:
3968:
3965:
3963:
3960:
3958:
3955:
3953:
3950:
3948:
3945:
3943:
3940:
3938:
3935:
3933:
3930:
3928:
3925:
3923:
3920:
3918:
3915:
3913:
3910:
3909:
3907:
3903:
3897:
3894:
3892:
3889:
3887:
3884:
3882:
3879:
3877:
3874:
3872:
3869:
3867:
3864:
3862:
3859:
3857:
3854:
3852:
3849:
3847:
3844:
3842:
3839:
3837:
3834:
3832:
3829:
3827:
3824:
3822:
3819:
3817:
3814:
3812:
3809:
3807:
3804:
3802:
3799:
3797:
3794:
3792:
3789:
3787:
3784:
3782:
3779:
3777:
3774:
3772:
3769:
3767:
3764:
3762:
3759:
3757:
3754:
3752:
3749:
3747:
3744:
3742:
3739:
3737:
3734:
3732:
3729:
3727:
3724:
3722:
3719:
3717:
3714:
3712:
3709:
3707:
3704:
3703:
3701:
3697:
3691:
3688:
3686:
3682:
3679:
3677:
3674:
3672:
3669:
3667:
3664:
3662:
3659:
3657:
3654:
3652:
3649:
3647:
3644:
3642:
3639:
3637:
3634:
3630:
3627:
3625:
3622:
3621:
3620:
3617:
3615:
3612:
3610:
3607:
3605:
3602:
3600:
3597:
3595:
3592:
3590:
3587:
3585:
3582:
3580:
3577:
3575:
3572:
3570:
3567:
3565:
3562:
3560:
3557:
3555:
3552:
3549:
3546:
3544:
3540:
3537:
3535:
3532:
3528:
3525:
3523:
3520:
3519:
3518:
3515:
3513:
3510:
3506:
3503:
3501:
3498:
3497:
3496:
3493:
3491:
3488:
3486:
3483:
3481:
3478:
3476:
3473:
3471:
3468:
3466:
3463:
3461:
3458:
3456:
3453:
3452:
3450:
3446:
3440:
3437:
3435:
3432:
3430:
3427:
3425:
3422:
3420:
3417:
3415:
3412:
3410:
3407:
3405:
3402:
3400:
3397:
3395:
3392:
3390:
3387:
3385:
3382:
3380:
3377:
3375:
3372:
3370:
3367:
3365:
3362:
3360:
3357:
3353:
3350:
3348:
3345:
3344:
3343:
3340:
3338:
3335:
3333:
3330:
3328:
3325:
3321:
3318:
3316:
3313:
3311:
3308:
3307:
3306:
3303:
3301:
3298:
3296:
3293:
3291:
3288:
3286:
3283:
3279:
3276:
3274:
3271:
3270:
3269:
3266:
3264:
3261:
3259:
3256:
3254:
3251:
3249:
3246:
3244:
3241:
3239:
3236:
3232:
3229:
3227:
3224:
3223:
3222:
3219:
3216:
3213:
3211:
3208:
3206:
3203:
3201:
3198:
3196:
3192:
3189:
3187:
3184:
3180:
3177:
3175:
3172:
3170:
3167:
3166:
3165:
3162:
3160:
3157:
3155:
3152:
3150:
3147:
3145:
3142:
3140:
3137:
3136:
3134:
3130:
3124:
3121:
3119:
3116:
3114:
3111:
3109:
3106:
3104:
3101:
3099:
3096:
3094:
3091:
3089:
3086:
3084:
3081:
3079:
3076:
3074:
3071:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3029:
3026:
3024:
3021:
3019:
3016:
3014:
3011:
3009:
3006:
3004:
3001:
2997:
2994:
2992:
2989:
2988:
2987:
2984:
2980:
2977:
2975:
2972:
2971:
2970:
2967:
2965:
2962:
2960:
2957:
2955:
2952:
2950:
2947:
2945:
2942:
2940:
2937:
2935:
2932:
2930:
2927:
2925:
2922:
2920:
2917:
2915:
2912:
2910:
2907:
2903:
2900:
2898:
2895:
2894:
2893:
2890:
2888:
2885:
2883:
2880:
2878:
2875:
2873:
2870:
2868:
2865:
2863:
2860:
2859:
2857:
2853:
2847:
2844:
2842:
2839:
2837:
2834:
2832:
2829:
2827:
2824:
2822:
2819:
2817:
2814:
2812:
2809:
2807:
2803:
2800:
2798:
2795:
2793:
2790:
2788:
2785:
2783:
2780:
2778:
2775:
2771:
2768:
2766:
2763:
2761:
2758:
2756:
2753:
2751:
2748:
2746:
2743:
2742:
2741:
2738:
2736:
2733:
2731:
2728:
2726:
2723:
2721:
2718:
2716:
2713:
2709:
2706:
2704:
2701:
2700:
2699:
2696:
2694:
2691:
2689:
2686:
2684:
2681:
2679:
2676:
2674:
2671:
2669:
2666:
2664:
2661:
2659:
2656:
2652:
2649:
2647:
2644:
2642:
2639:
2637:
2634:
2632:
2629:
2627:
2624:
2623:
2622:
2619:
2615:
2612:
2610:
2607:
2605:
2602:
2601:
2600:
2597:
2595:
2592:
2588:
2585:
2583:
2580:
2578:
2575:
2574:
2573:
2570:
2568:
2565:
2563:
2560:
2558:
2555:
2553:
2550:
2548:
2545:
2543:
2540:
2538:
2535:
2533:
2530:
2528:
2525:
2523:
2520:
2519:
2517:
2513:
2507:
2504:
2500:
2497:
2495:
2492:
2490:
2487:
2485:
2482:
2480:
2477:
2475:
2472:
2471:
2470:
2467:
2465:
2462:
2460:
2457:
2455:
2452:
2450:
2447:
2445:
2442:
2440:
2437:
2433:
2430:
2428:
2425:
2423:
2420:
2418:
2415:
2414:
2413:
2410:
2408:
2405:
2403:
2400:
2398:
2395:
2393:
2390:
2388:
2385:
2383:
2380:
2378:
2375:
2373:
2370:
2368:
2365:
2361:
2358:
2356:
2353:
2352:
2351:
2348:
2346:
2343:
2341:
2338:
2336:
2333:
2331:
2328:
2326:
2323:
2321:
2318:
2316:
2313:
2311:
2308:
2306:
2303:
2301:
2298:
2296:
2293:
2291:
2288:
2286:
2283:
2281:
2278:
2274:
2271:
2269:
2266:
2265:
2264:
2261:
2259:
2256:
2254:
2251:
2249:
2246:
2242:
2239:
2237:
2234:
2232:
2229:
2227:
2224:
2223:
2222:
2219:
2217:
2214:
2212:
2209:
2205:
2202:
2201:
2200:
2197:
2195:
2192:
2190:
2187:
2185:
2182:
2180:
2177:
2173:
2170:
2168:
2165:
2163:
2160:
2159:
2158:
2155:
2153:
2150:
2146:
2143:
2141:
2138:
2136:
2133:
2131:
2128:
2126:
2123:
2122:
2121:
2118:
2117:
2115:
2111:
2106:
2102:
2098:
2091:
2086:
2084:
2079:
2077:
2072:
2071:
2068:
2054:
2051:
2049:
2046:
2044:
2041:
2040:
2039:
2035:
2032:
2028:
2025:
2023:
2020:
2019:
2018:
2015:
2014:
2012:
2010:
2006:
1998:
1995:
1993:
1990:
1988:
1985:
1983:
1980:
1978:
1975:
1974:
1973:
1970:
1969:
1967:
1965:
1961:
1955:
1951:
1948:
1944:
1941:
1939:
1936:
1935:
1934:
1931:
1929:
1928:
1926:
1924:
1920:
1908:
1904:
1900:
1897:
1895:
1891:
1887:
1884:
1883:
1882:
1879:
1875:
1872:
1870:
1866:
1862:
1859:
1857:
1853:
1849:
1845:
1841:
1837:
1834:
1833:
1832:
1829:
1828:
1826:
1824:
1820:
1810:
1807:
1805:
1801:
1798:
1797:
1792:
1789:
1787:
1784:
1782:
1779:
1778:
1777:
1776:CSF receptors
1773:
1772:
1770:
1766:
1758:
1755:
1753:
1749:
1745:
1742:
1741:
1740:
1737:
1736:
1734:
1732:
1728:
1722:
1719:
1717:
1714:
1712:
1709:
1705:
1701:
1698:
1696:
1692:
1689:
1687:
1684:
1683:
1682:
1679:
1678:
1676:
1674:
1670:
1664:
1661:
1657:
1653:
1650:
1648:
1644:
1641:
1640:
1639:
1636:
1635:
1633:
1631:
1627:
1619:
1616:
1614:
1611:
1609:
1605:
1602:
1600:
1596:
1592:
1588:
1585:
1583:
1579:
1575:
1571:
1568:
1567:
1566:
1563:
1562:
1560:
1558:
1554:
1551:
1549:
1545:
1542:
1540:
1536:
1526:
1523:
1520:
1518:
1515:
1512:
1510:
1507:
1504:
1503:
1501:
1497:
1491:
1488:
1485:
1483:
1480:
1477:
1475:
1472:
1469:
1467:
1464:
1461:
1459:
1456:
1453:
1451:
1448:
1445:
1443:
1440:
1437:
1435:
1432:
1429:
1427:
1424:
1421:
1419:
1416:
1413:
1411:
1408:
1405:
1403:
1400:
1397:
1395:
1392:
1389:
1387:
1384:
1381:
1380:
1378:
1374:
1368:
1365:
1362:
1360:
1357:
1354:
1352:
1349:
1346:
1344:
1341:
1338:
1336:
1333:
1330:
1328:
1325:
1322:
1320:
1317:
1314:
1312:
1309:
1306:
1304:
1301:
1298:
1296:
1293:
1290:
1289:
1287:
1283:
1280:
1278:
1274:
1264:
1261:
1259:
1256:
1252:
1249:
1248:
1246:
1242:
1239:
1238:
1236:
1235:
1233:
1229:
1223:
1220:
1218:
1215:
1213:
1210:
1208:
1205:
1203:
1200:
1196:
1193:
1191:
1188:
1187:
1186:
1183:
1182:
1180:
1178:
1174:
1168:
1165:
1163:
1160:
1158:
1155:
1153:
1150:
1148:
1145:
1143:
1140:
1138:
1135:
1133:
1130:
1128:
1125:
1123:
1120:
1118:
1114:
1111:
1110:
1108:
1106:
1102:
1099:
1096:
1091:
1087:
1083:
1076:
1071:
1069:
1064:
1062:
1057:
1056:
1053:
1046:
1042:
1039:
1038:
1034:
1026:
1022:
1018:
1014:
1010:
1006:
1003:(7): 662–72.
1002:
998:
991:
988:
983:
979:
975:
971:
967:
963:
956:
953:
948:
944:
939:
934:
930:
926:
923:(2): 153–65.
922:
918:
914:
907:
905:
903:
901:
897:
892:
888:
883:
878:
874:
870:
866:
862:
858:
851:
849:
847:
845:
843:
841:
839:
835:
830:
828:9780781765190
824:
820:
813:
811:
807:
802:
798:
794:
790:
786:
782:
778:
774:
770:
766:
759:
755:
749:
746:
740:
738:
737:
730:
728:
721:
719:
717:
713:
709:
701:
699:
697:
693:
689:
685:
681:
677:
673:
669:
665:
661:
657:
652:
645:
643:
639:
635:
631:
627:
623:
619:
615:
611:
610:cell membrane
603:
601:
599:
594:
592:
588:
584:
580:
575:
568:
566:
564:
560:
552:
548:
540:
538:
536:
532:
528:
524:
520:
516:
512:
499:
496:
492:
489:
486:
482:
477:
473:
470:
469:
465:
462:
460:
456:
451:
448:
445:
443:
439:
436:
433:
431:
427:
424:
421:
419:
415:
412:
409:
407:
403:
400:
397:
395:
391:
387:
383:
380:
377:
373:
368:
364:
359:
355:
351:
347:
336:
333:
329:
326:
323:
319:
314:
310:
307:
306:
302:
299:
297:
293:
288:
285:
282:
280:
276:
273:
270:
268:
264:
261:
258:
256:
252:
249:
246:
244:
240:
237:
234:
232:
228:
224:
220:
217:
214:
210:
205:
201:
196:
193:
189:
178:
175:
171:
168:
165:
161:
156:
152:
149:
148:
144:
141:
139:
135:
130:
127:
124:
122:
118:
115:
112:
110:
106:
103:
100:
98:
94:
91:
88:
86:
82:
79:
76:
74:
70:
66:
62:
59:
56:
52:
47:
43:
38:
35:
31:
19:
5354:
5342:M-CSFR/CSF1R
5329:heterodimer)
5315:heterodimer)
5244:Antagonists:
5243:
5215:
5194:
5173:
5133:
5112:
5085:Risankizumab
5066:
5056:
5034:
5024:
5007:NNC0114-0006
5002:NNC0114-0005
4998:
4983:
4961:
4941:
4920:
4895:
4849:
4814:
4788:
4771:Tralokinumab
4766:Lebrikizumab
4761:Anrukinzumab
4757:
4732:
4706:
4691:
4665:
4639:
4618:
4608:
4567:
4510:Clazakizumab
4501:
4486:
4465:
4449:Benralizumab
4445:
4436:Antagonists:
4435:
4425:
4408:Pascolizumab
4399:
4390:Antagonists:
4389:
4369:
4323:
4292:
4247:
4226:
4206:
4182:Antagonists:
4181:
4152:
3618:
3538:
3516:
3494:
3341:
3304:
3267:
3220:
3190:
3163:
2985:
2891:
2739:
2468:
2220:
1964:IL 17 family
1569:
1524:
1516:
1508:
1489:
1481:
1473:
1465:
1457:
1449:
1441:
1433:
1425:
1417:
1409:
1401:
1393:
1385:
1366:
1358:
1350:
1342:
1334:
1332:Fas receptor
1326:
1318:
1310:
1302:
1294:
1277:TNF receptor
1000:
996:
990:
965:
961:
955:
920:
916:
864:
860:
818:
768:
764:
748:
734:
725:
705:
653:
646:
607:
595:
576:
572:
544:
523:immune cells
514:
510:
508:
466:
385:Alt. symbols
303:
222:Alt. symbols
145:
64:Alt. symbols
5095:Ustekinumab
5075:Briakinumab
5067:Antibodies:
5038:Fezakinumab
5035:Antibodies:
4999:Antibodies:
4987:Denenicokin
4962:Antibodies:
4899:Iboctadekin
4878:Vunakizumab
4873:Secukinumab
4863:Perakizumab
4850:Antibodies:
4758:Antibodies:
4715:Ustekinumab
4710:Briakinumab
4707:Antibodies:
4619:Antibodies:
4545:Tocilizumab
4515:Elsilimomab
4502:Antibodies:
4454:Mepolizumab
4446:Antibodies:
4400:Antibodies:
4327:Daniplestim
4296:Basiliximab
4293:Antibodies:
4261:Celmoleukin
4256:Aldesleukin
4220:Lutikizumab
4215:Gevokizumab
4210:Canakinumab
4207:Antibodies:
1450:(TNFRSF13C)
1442:(TNFRSF13B)
1434:(TNFRSF12A)
1426:(TNFRSF11B)
1418:(TNFRSF11A)
1410:(TNFRSF10D)
1402:(TNFRSF10C)
1394:(TNFRSF10B)
1386:(TNFRSF10A)
708:basiliximab
541:Composition
527:lymphocytes
488:Swiss-model
370:Identifiers
325:Swiss-model
207:Identifiers
167:Swiss-model
49:Identifiers
5382:Categories
5150:B (IFN-λ3)
5146:A (IFN-λ2)
5080:Guselkumab
5070:Brazikumab
4965:Fletikumab
4868:Remtolumab
4858:Ixekizumab
4853:Brodalumab
4736:Binetrakin
4674:Oprelvekin
4643:Ilodecakin
4622:Enokizumab
4535:Siltuximab
4525:Olokizumab
4459:Reslizumab
4393:Pitrakinra
4373:Binetrakin
4342:Milodistim
4337:Leridistim
4306:Inolimomab
4281:Teceleukin
4200:Isunakinra
4137:modulators
2103:(see also
1525:(TNFRSF27)
1517:(TNFRSF25)
1509:(TNFRSF21)
1490:(TNFRSF19)
1482:(TNFRSF18)
1474:(TNFRSF17)
1466:(TNFRSF16)
1458:(TNFRSF14)
1343:(TNFRSF6B)
1303:(TNFRSF1B)
1295:(TNFRSF1A)
741:References
712:daclizumab
666:. In the
525:, such as
484:Structures
479:Search for
453:Other data
321:Structures
316:Search for
290:Other data
163:Structures
158:Search for
132:Other data
5355:Unsorted:
5216:Agonists:
5195:Agonists:
5174:Agonists:
5134:Agonists:
5113:Agonists:
5057:Agonists:
5025:Agonists:
4984:Agonists:
4942:Agonists:
4914:Tadekinig
4896:Agonists:
4815:Agonists:
4789:Agonists:
4733:Agonists:
4692:Agonists:
4666:Agonists:
4640:Agonists:
4609:Agonists:
4568:Agonists:
4550:Levilimab
4540:Sirukumab
4530:Sarilumab
4487:Agonists:
4426:Agonists:
4403:Dupilumab
4370:Agonists:
4347:Muplestim
4324:Agonists:
4248:Agonists:
4175:Pifonakin
4170:Mobenakin
4153:Agonists:
1809:prolactin
1367:(TNFRSF9)
1359:(TNFRSF8)
1351:(TNFRSF7)
1335:(TNFRSF6)
1327:(TNFRSF5)
1319:(TNFRSF4)
1311:(TNFRSF3)
686:and into
656:tolerance
604:Signaling
547:α (alpha)
435:NM_000206
394:NCBI gene
272:NM_000878
231:NCBI gene
114:NM_000417
73:NCBI gene
67:IL2R CD25
5309:IL-22Rα1
5275:instead.
4592:instead.
4520:mAb 1339
4505:ARGX-109
4469:TPI ASM8
4439:YM-90709
4190:Anakinra
4185:AF-12198
2097:Proteins
2038:TGF-beta
1539:JAK-STAT
1487:TAJ/TROY
1017:23279211
982:22650257
947:20732639
917:Immunity
891:21889323
801:85394260
793:16293754
731:See also
660:immunity
583:NK cells
565:family.
551:β (beta)
531:cytokine
498:InterPro
335:InterPro
177:InterPro
5327:IL-10Rβ
5323:IL-20Rα
5313:IL-20Rβ
5247:IL-36RA
4792:ALT-803
3905:301–350
3699:251–300
3651:CD240CE
3448:201–250
3132:151–200
2855:101–150
2034:Ser/Thr
1856:IL22RA2
1852:IL22RA1
1823:Type II
1752:IL12RB2
1748:IL12RB1
1731:IL12RB1
1630:β-chain
1599:IL13RA2
1595:IL13RA1
1557:γ-chain
1025:3296555
938:2946796
882:3405730
773:Bibcode
765:Science
761:
722:History
692:antigen
664:T cells
628:called
620:called
587:T cells
533:called
517:) is a
494:Domains
442:UniProt
331:Domains
301:Chr. 22
279:UniProt
173:Domains
143:Chr. 10
121:UniProt
5283:Others
5256:Others
5208:IL1RL2
5187:IL1RL1
4924:IL18BP
4195:IL-1RA
3912:CD300A
3871:CDw293
3656:CD240D
3517:CD213a
3495:CDw210
3460:CD202b
3434:CDw199
3429:CDw198
3083:CD140b
2515:51–100
2053:family
2048:TGFBR2
2043:TGFBR1
1997:IL17RE
1992:IL17RD
1987:IL17RC
1982:IL17RB
1977:IL17RA
1954:IL18R1
1907:IFNGR2
1903:IFNGR1
1894:IFNAR2
1890:IFNAR1
1869:IL20RB
1865:IL20RA
1844:IL10RB
1840:IL10RA
1774:other
1704:IL27RA
1695:IL11RA
1663:GM-CSF
1548:Type I
1431:TweakR
1263:CMKLR1
1241:CX3CR1
1047:(MeSH)
1023:
1015:
980:
945:
935:
889:
879:
825:
799:
791:
668:thymus
636:, the
618:enzyme
464:Chr. X
447:P31785
430:RefSeq
423:308380
375:Symbol
284:P14784
267:RefSeq
260:146710
212:Symbol
126:P01589
109:RefSeq
102:147730
54:Symbol
5166:IL-31
5126:IL-28
5105:IL-27
5049:IL-23
5017:IL-22
4976:IL-21
4934:IL-20
4888:IL-18
4807:IL-17
4781:IL-15
4725:IL-13
4684:IL-12
4658:IL-11
4632:IL-10
4092:CD350
4087:CD349
4082:CD344
4077:CD340
4072:CD339
4067:CD338
4062:CD337
4057:CD336
4052:CD335
4047:CD334
4042:CD333
4037:CD332
4032:CD331
4027:CD329
4022:CD328
4017:CD327
4012:CD326
4007:CD325
4002:CD324
3997:CD322
3992:CD321
3987:CD320
3982:CD318
3977:CD317
3972:CD316
3967:CD315
3962:CD314
3957:CD312
3952:CD309
3947:CD307
3942:CD306
3937:CD305
3932:CD304
3927:CD303
3922:CD302
3917:CD301
3896:CD299
3891:CD298
3886:CD297
3881:CD295
3876:CD294
3866:CD292
3861:CD290
3856:CD289
3851:CD288
3846:CD286
3841:CD284
3836:CD283
3831:CD282
3826:CD281
3821:CD280
3816:CD279
3811:CD278
3806:CD276
3801:CD275
3796:CD274
3791:CD273
3786:CD272
3781:CD271
3776:CD269
3771:CD268
3766:CD267
3761:CD266
3756:CD265
3751:CD264
3746:CD263
3741:CD262
3736:CD261
3731:CD258
3726:CD257
3721:CD256
3716:CD254
3711:CD253
3706:CD252
3690:CD249
3685:CD248
3681:CD247
3676:CD246
3671:CD244
3666:CD243
3661:CD241
3646:CD239
3641:CD238
3636:CD236
3619:CD235
3614:CD234
3609:CD233
3604:CD230
3599:CD229
3594:CD228
3589:CD227
3584:CD226
3579:CD225
3574:CD224
3569:CD223
3564:CD222
3559:CD221
3554:CD220
3539:CD218
3534:CD217
3512:CD212
3490:CD209
3485:CD208
3480:CD207
3475:CD206
3470:CD205
3465:CD204
3455:CD201
3439:CD200
3424:CD197
3419:CD196
3414:CD195
3409:CD194
3404:CD193
3399:CD192
3394:CD191
3389:CD186
3384:CD185
3379:CD184
3374:CD183
3369:CD182
3364:CD181
3359:CD180
3342:CD179
3337:CD178
3332:CD177
3327:CD174
3305:CD172
3300:CD171
3295:CD170
3290:CD169
3285:CD168
3268:CD167
3263:CD166
3258:CD164
3253:CD163
3248:CD162
3243:CD161
3238:CD160
3221:CD159
3191:CD158
3186:CD157
3164:CD156
3159:CD155
3154:CD154
3149:CD153
3144:CD152
3139:CD151
3123:CD150
3118:CD148
3113:CD147
3108:CD146
3103:CD144
3098:CD143
3093:CD142
3088:CD141
3078:CD138
3073:CD137
3068:CD136
3063:CD135
3058:CD134
3053:CD133
3048:CD132
3043:CD131
3038:CD130
3033:CD129
3028:CD127
3023:CD126
3018:CD125
3013:CD124
3008:CD123
3003:CD122
2986:CD121
2969:CD120
2964:CD119
2959:CD118
2954:CD117
2949:CD116
2944:CD115
2939:CD114
2934:CD113
2929:CD112
2924:CD111
2919:CD110
2914:CD109
2909:CD108
2892:CD107
2887:CD106
2882:CD105
2877:CD104
2872:CD103
2867:CD102
2862:CD101
2846:CD100
2022:CSF1R
1950:IL18R
1943:IL1R2
1938:IL1R1
1874:IL28R
1861:IL20R
1848:IL22R
1836:IL10R
1786:G-CSF
1768:Other
1757:IL23R
1744:IL12R
1721:CNTFR
1686:IL6RA
1673:gp130
1656:IL5RA
1647:IL3RA
1618:IL21R
1608:IL7RA
1591:IL13R
1582:IL15R
1578:IL2RB
1574:IL2RA
1522:EDA2R
1499:21-27
1447:BAFFR
1376:11-20
1364:CD137
1316:CD134
1300:TNFR2
1292:TNFR1
1258:CCBP2
1237:CX3C
1231:Other
1222:CXCR7
1217:CXCR6
1212:CXCR5
1207:CXCR4
1202:CXCR3
1195:CXCR2
1190:CXCR1
1167:CCR10
1127:CCRL2
1117:CCRL1
1095:GPCRs
1021:S2CID
797:S2CID
515:IL-2R
459:Locus
379:IL2RG
296:Locus
225:CD122
216:IL2RB
147:p15.1
138:Locus
58:IL2RA
5273:here
5271:See
4601:IL-9
4590:here
4581:IL-8
4560:IL-7
4479:IL-6
4418:IL-5
4362:IL-4
4316:IL-3
4240:IL-2
4145:IL-1
2841:CD99
2836:CD98
2831:CD97
2826:CD96
2821:CD95
2816:CD94
2811:CD93
2806:CD92
2802:CD91
2797:CD90
2792:CD89
2787:CD88
2782:CD87
2777:CD86
2740:CD85
2735:CD84
2730:CD83
2725:CD82
2720:CD81
2715:CD80
2698:CD79
2693:CD78
2688:CD74
2683:CD73
2678:CD72
2673:CD71
2668:CD70
2663:CD69
2658:CD68
2621:CD66
2599:CD64
2594:CD63
2572:CD62
2567:CD61
2562:CD59
2557:CD58
2552:CD57
2547:CD56
2542:CD55
2537:CD54
2532:CD53
2527:CD52
2522:CD51
2506:CD50
2469:CD49
2464:CD48
2459:CD47
2454:CD46
2449:CD45
2444:CD44
2439:CD43
2412:CD42
2407:CD41
2402:CD40
2397:CD39
2392:CD38
2387:CD37
2382:CD36
2377:CD35
2372:CD34
2367:CD33
2350:CD32
2345:CD31
2340:CD30
2335:CD29
2330:CD28
2325:CD27
2320:CD26
2315:CD25
2310:CD24
2305:CD23
2300:CD22
2295:CD21
2290:CD20
2285:CD19
2280:CD18
2263:CD16
2258:CD15
2253:CD14
2248:CD13
2221:CD11
2216:CD10
2113:1–50
1972:IL17
1886:-α/β
1716:LIFR
1711:OSMR
1652:IL5R
1643:IL3R
1613:IL9R
1604:IL7R
1587:IL4R
1570:IL2R
1479:GITR
1471:BCMA
1463:NGFR
1455:HVEM
1439:TACI
1415:RANK
1407:DcR2
1399:DcR1
1356:CD30
1348:CD27
1340:DcR3
1324:CD40
1308:LTBR
1285:1-10
1251:XCR1
1185:IL-8
1162:CCR9
1157:CCR8
1152:CCR7
1147:CCR6
1142:CCR5
1137:CCR4
1132:CCR3
1122:CCR2
1113:CCR1
1013:PMID
978:PMID
943:PMID
887:PMID
823:ISBN
789:PMID
758:2B5I
710:and
658:and
630:JAK3
589:and
581:and
535:IL-2
509:The
418:OMIM
411:6010
406:HGNC
399:3561
255:OMIM
248:6009
243:HGNC
236:3560
97:OMIM
90:6008
85:HGNC
78:3559
5299:CD4
5264:JAK
2211:CD9
2199:CD8
2194:CD7
2189:CD6
2184:CD5
2179:CD4
2157:CD3
2152:CD2
2125:a-c
2120:CD1
2027:KIT
2017:Tyr
1933:IL1
1781:EPO
1514:DR3
1506:DR6
1391:DR5
1383:DR4
1247:XC
1177:CXC
1005:doi
970:doi
933:PMC
925:doi
877:PMC
869:doi
781:doi
769:310
754:PDB
468:q13
305:q13
5384::
5229:,
5225:,
5148:,
4840:,
4836:,
4832:,
4828:,
4824:,
4162:,
3683:-
2804:-
2145:1E
2140:1D
2135:1B
2130:1A
2099::
2036::
1952:/
1905:/
1899:-γ
1888:/
1867:/
1863:/
1854:/
1850:/
1846:/
1842:/
1838:/
1804:GH
1802::
1700:27
1691:11
1654:/
1645:/
1606:/
1597:/
1593:/
1589:/
1580:/
1572:/
1115:/
1105:CC
1019:.
1011:.
1001:26
999:.
976:.
966:18
964:.
941:.
931:.
921:33
919:.
915:.
899:^
885:.
875:.
865:23
863:.
859:.
837:^
809:^
795:.
787:.
779:.
767:.
756::
718:.
698:.
644:.
557:,
537:.
5344:)
5325:/
5311:/
5301:)
5233:)
5231:γ
5227:β
5223:α
5221:(
5152:)
5144:(
4844:)
4842:F
4834:D
4830:C
4826:B
4822:A
4820:(
4166:)
4164:β
4160:α
4158:(
4126:e
4119:t
4112:v
3629:b
3624:a
3550:)
3548:b
3543:a
3541:(
3527:2
3522:1
3505:b
3500:a
3352:b
3347:a
3320:g
3315:b
3310:a
3278:b
3273:a
3231:c
3226:a
3217:)
3215:k
3210:i
3205:e
3200:d
3195:a
3193:(
3179:c
3174:b
3169:a
2996:b
2991:a
2979:b
2974:a
2902:b
2897:a
2770:k
2765:j
2760:h
2755:e
2750:d
2745:a
2708:b
2703:a
2651:f
2646:e
2641:d
2636:c
2631:b
2626:a
2614:C
2609:B
2604:A
2587:P
2582:L
2577:E
2499:f
2494:e
2489:d
2484:c
2479:b
2474:a
2432:d
2427:c
2422:b
2417:a
2360:B
2355:A
2273:B
2268:A
2241:d
2236:c
2231:b
2226:a
2204:a
2172:ε
2167:δ
2162:γ
2107:)
2089:e
2082:t
2075:v
1901:/
1892:/
1750:/
1746:/
1702:/
1693:/
1576:/
1097:)
1093:(
1074:e
1067:t
1060:v
1027:.
1007::
984:.
972::
949:.
927::
893:.
871::
831:.
803:.
783::
775::
649:c
555:c
513:(
356:)
352:(
20:)
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