1503:. In this condition, immune cells react to inflammatory molecules released within the skin around the joints and scalp. This response causes the epidermal cells to recycle more rapidly than usual, which leads to the formation of red, scaly lesions and chronic skin inflammation. Analysis of biopsies taken from lesions of psoriasis patients show an enrichment of cytotoxic T cells and neutrophils containing IL-17. This indicates an excessive infiltration of pro-inflammatory immune cells and IL-17 cytokines are associated with the development of psoriasis.
1688:
endothelial cells, peripheral T cells, B cell lineages, fibroblast, lung, myelomonocytic cells, and marrow stromal cells. Signal transduction for both IL-17A and IL-17F requires the presence of a heterodimeric complex consisting of both IL-17RA and IL-17RC and the absence of either receptor results in ineffective signal transduction. This pattern is reciprocated for other members of the IL-17 family such as IL-17E, which requires an IL-17RA-IL-17RB complex (also known as IL-17Rh1, IL-17BR or IL-25R) for effective function.
1598:. IL-17F is clearly expressed in the airway of asthmatics and its expression level is correlated with disease severity. Moreover, a coding region variant (H161R) of the IL-17F gene is inversely associated with asthma and encodes an antagonist for the wild-type IL-17F. IL-17F is able to induce several cytokines, chemokines and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts and eosinophils. IL-17F utilizes IL-17RA and IL-17RC as its receptors and activates the
1602:. IL-17F is derived from several cell types such as Th17 cells, mast cells and basophils, and shows a wide tissue expression pattern including lung. Overexpression of IL-17F gene in the airway of mice is associated with airway neutrophilia, the induction of many cytokines, an increase in airway hyperreactivity, and mucus hypersecretion. Hence, IL-17F may have a crucial role in allergic airway inflammation and have important therapeutic implications in asthma.
870:
1585:
DCs are also recruited by CCL20 via chemotaxis where their activation restarts and amplifies the cycle of inflammation. IL-17 and additional cytokines released from the influx of neutrophils, T and dendritic cells mediate effects on localized leukocytes and keratinocytes that supports the progression of psoriasis by inciting chronic inflammation.
1584:
cells. Reduced regulation allows uninhibited proliferation of Th17 cells and production of IL-17 in psoriatic lesions, augmenting IL-17 signaling. Antimicrobial peptides and IL-8 attract neutrophils to the site of injury where these cells remove damaged and inflamed keratinocyte cells. New immature
1195:
Numerous immune regulatory functions have been reported for the IL-17 family of cytokines, presumably due to their induction of many immune signaling molecules. The most notable role of IL-17 is its involvement in inducing and mediating proinflammatory responses. IL-17 is commonly associated with
1182:
shape of the entire protein molecule. To the reference, the members of the IL-17 family do not exhibit a significant sequence homology with other cytokines. Among IL-17 family members, the IL-17F isoforms 1 and 2 (ML-1) have the highest sequence homology with IL-17A (55 and 40%, respectively). They
1687:
The IL-17 receptor family consists of five, broadly distributed receptors (IL-17RA, B, C, D and E) that present with individual ligand specificities. Within this family of receptors, IL-17RA is the best-described. IL-17RA binds both IL-17A and IL-17F and is expressed in multiple tissues: vascular
1696:
to produce a soluble receptor in addition to its cell membrane-bound form. In a similar manner, the gene for IL-17RD may undergo alternative splicing to yield a soluble receptor. This feature may allow these receptors to inhibit the stimulatory effects of their yet-undefined ligands. The
3301:
Leonardi CL, Kimball AB, Papp KA, Yeilding N, Guzzo C, Wang Y, et al. (May 2008). "Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)".
1122:. Acting as chemoattractants, these chemokines recruit the immune cells, such as monocytes and neutrophils to the site of inflammation. Typically, the signaling events mentioned above follow an invasion of the body by pathogens. Promoting the inflammation, IL-17 acts in concert with
1691:
Another member of this receptor family, IL-17RB, binds both IL-17B and IL-17E. Furthermore, it is expressed in the kidney, pancreas, liver, brain, and intestine. IL-17RC is expressed by the prostate, cartilage, kidney, liver, heart, and muscle, and its gene may undergo
1278:
The release of cytokines causes many functions, such as airway remodeling, a characteristic of IL-17 responses. The increased expression of chemokines attracts other cells including neutrophils but not eosinophils. IL-17 function is also essential to a subset of
1700:
Signal transduction by these receptors is as diverse as their distribution. These receptors do not exhibit a significant similarity in extracellular or intracellular amino acid sequence when compared to other cytokine receptors. Transcription factors such as
1721:
have been implicated in IL-17 mediated signaling in a stimulation-dependent, tissue-specific manner. Other signaling mechanisms have also been proposed, but more work is needed to fully elucidate the true signaling pathways used by these diverse receptors.
1459:
site on the protein was first identified after purification of the protein revealed two bands, one at 15 KDa and another at 20 KDa. Comparison of different members of the IL-17 family revealed four conserved cysteines that form two
1649:
Based on emerging evidence from animal models, IL-17 has been suggested as a target for anti-inflammatory therapies to improve recovery post-stroke and to reduce the formation of skin cancer. IL-17 has also been implicated in
1593:
The IL-17F gene was discovered in 2001 and is located on chromosome 6p12. Notably, among this family, IL-17F has been well characterized both in vitro and in vivo and has been shown to have a pro-inflammatory role in
1394:
regions of both IL-17A and IL-17F increasing their gene activity. In contrast, some scientists believe IL-17 induction is independent of IL-23. Several groups have identified ways to induce IL-17 production both
3185:
Cleve H, Kirk RL, Gajdusek DC, Guiart J (1967). "On the distribution of the Gc variant Gc
Aborigine in Melanesian populations; determination of Gc-types in sera from Tongariki Island, New Hebrides".
1411:, without the need for IL-23. Although IL-23 is not required for IL-17 expression in this situation, IL-23 may play a role in promoting survival and/or proliferation of the IL-17 producing
4758:
2596:
Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. (May 2006). "Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells".
1514:. Similarly, mice genetically modifying to not express IL-23 or IL-17 receptors significantly reduced psoriatic lesion development upon stimulation with the lesion-causing tumor promoter
3220:
Seppälä M, Rönnberg L, Karonen SL, Kauppila A (August 1987). "Micronized oral progesterone increases the circulating level of endometrial secretory PP14/beta-lactoglobulin homologue".
1844:
Johansen C, Usher PA, Kjellerup RB, Lundsgaard D, Iversen L, Kragballe K (February 2009). "Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin".
1187:, the sequences of these cytokines are highly conserved. For instance, the sequence homology between the corresponding human and mouse proteins is usually between 62–88%.
1471:
The crystal structure of IL-17F, which is 50% homologous to IL-17A, revealed that IL-17F is structurally similar to the cystine knot family of proteins that includes the
4147:
105:
2261:
Zhu H, Wang Z, Yu J, Yang X, He F, Liu Z, et al. (July 2019). "Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage".
2391:"STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice"
4751:
904:
744:
597:
460:
315:
170:
1487:
replaces the cysteine at this position. This unique feature is conserved in the other IL-17 family members. IL-17F also dimerizes in a fashion similar to
1483:
stabilized by three disulfide interactions. However, in contrast to the other cystine knot proteins, IL-17F lacks the third disulfide bond. Instead, a
4744:
3276:
4223:
1525:
cells of the epidermal layer. Inflammation begins with keratinocyte cells entering the final stages of their cell cycle, which activates immature
5956:
5223:
4618:
6041:
6036:
6031:
5960:
5946:
5906:
1889:"CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene"
1564:
IL-17 interaction with IL-17RA receptors, abundant on the keratinocyte cell surface, incite epidermal cells to increase expression of IL-6,
6026:
6021:
5975:
1515:
3643:
928:
768:
621:
484:
339:
194:
5880:
1506:
Studies conducted in mice demonstrate that removing either IL-23 or IL-17 decreases the progression of psoriasis. Mice injected with
4828:
4509:
1428:
1451:
with a molecular mass of 35 kDa. Each subunit of the homodimer is approximately 15-20 KDa. The structure of IL-17 consists of a
1638:, for the treatment of moderate to severe plaque psoriasis. In addition, Cosentyx has been approved in Japan for use in treating
916:
756:
609:
472:
327:
182:
909:
4039:
3066:
Dombrowski Y, Schauber J (May 2012). "Cathelicidin LL-37: a defense molecule with a potential role in psoriasis pathogenesis".
1971:"Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis"
749:
602:
465:
320:
1610:
Because of its involvement in immune regulatory functions, IL-17 inhibitors are being investigated as possible treatments for
175:
2759:
Hu Y, Shen F, Crellin NK, Ouyang W (January 2011). "The IL-17 pathway as a major therapeutic target in autoimmune diseases".
1753:"IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding"
1291:
17) cells. As a result of these roles, the IL-17 family has been linked to many immune-related/autoimmune diseases including
1130:. Moreover, an activation of IL-17 signalling is often observed in the pathogenesis of various autoimmune disorders, such as
125:
5841:
5820:
3816:
3345:
Swardfager W, Winer DA, Herrmann N, Winer S, Lanctôt KL (March 2013). "Interleukin-17 in post-stroke neurodegeneration".
2494:"TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells"
4652:
4202:
3977:
3277:"First in the world regulatory approval of Novartis' Cosentyx(TM) in Japan for both psoriasis and psoriatic arthritis"
1118:. After binding to the receptor, IL-17 activates several signalling cascades that, in turn, lead to the induction of
2649:"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells"
4685:
4487:
4197:
1930:"Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis"
1623:
2350:"Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17"
4606:
4291:
3390:"Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17-producing CD4+ T cells"
1714:
4641:
4068:
4044:
1316:
1063:
1969:
Chiricozzi A, Guttman-Yassky E, Suárez-Fariñas M, Nograles KE, Tian S, Cardinale I, et al. (March 2011).
1378:
signalling pathways are required for this IL-23-mediated IL-17 production. Consistent with this finding, Chen
113:
1347:. IL-17B is expressed in several peripheral tissues and immune tissues. IL-17C is also highly upregulated in
5799:
5759:
5738:
5682:
5650:
5609:
5567:
5521:
5440:
5414:
5358:
5317:
5291:
5265:
4919:
3636:
1697:
least-described of these receptors, IL-17RE, is known to be expressed in the pancreas, brain, and prostate.
1682:
1179:
1103:
5374:
3255:
5234:
5214:
5193:
5112:
5051:
4995:
4949:
4873:
4778:
3969:
3109:
Kawaguchi M, Kokubu F, Fujita J, Huang SK, Hizawa N (December 2009). "Role of interleukin-17F in asthma".
1565:
1455:
of 23 amino acids (aa) followed by a 123-aa chain region characteristic of the IL-17 family. An N-linked
1335:
long and was cloned from CD4+ T cells. Each member of the IL-17 family has a distinct pattern of cellular
921:
761:
1809:
Moseley TA, Haudenschild DR, Rose L, Reddi AH (April 2003). "Interleukin-17 family and IL-17 receptors".
614:
477:
332:
187:
6046:
3280:
1510:
targeting IL-17 blocked, or neutralized, down-stream signaling of this cytokine and decreased epidermal
1507:
1123:
874:
814:
667:
530:
4884:
1183:
follow by IL-17B, which has 29% similarity to IL-17A, IL-17D (25%), IL-17C (23%), and IL-17E (17%). In
109:
5996:
3439:"Vitamin D suppresses Th17 cytokine production by inducing C/EBP homologous protein (CHOP) expression"
5779:
4767:
4495:
3017:
Krueger JG, Fretzin S, Suárez-Fariñas M, Haslett PA, Phipps KM, Cameron GS, et al. (July 2012).
2768:
2605:
2549:
2443:
1615:
1550:
1521:
IL-17 promotes psoriasis by contributing to the inflammatory response that damages and overturns the
1292:
986:
385:
240:
4909:
2647:
Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, et al. (September 2006).
2052:
Martin DA, Towne JE, Kricorian G, Klekotka P, Gudjonsson JE, Krueger JG, Russell CB (January 2013).
5770:
5328:
5123:
4899:
4793:
4337:
3019:"IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis"
1639:
1635:
1488:
1351:
conditions, although in resting conditions is low in abundance. IL-17D is highly expressed in the
1300:
1095:
5640:
5635:
5620:
5532:
5511:
4960:
4894:
4853:
4797:
4770:
4504:
4461:
4376:
4219:
4083:
3629:
3608:
3370:
3327:
3091:
2971:"Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model"
2792:
2678:
2629:
2575:
2286:
2243:
2191:
1869:
1693:
1651:
1611:
1391:
1312:
1264:
5501:
5369:
5276:
5255:
5006:
4975:
4970:
4914:
4833:
3536:"The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases"
2054:"The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings"
1576:. Increased concentration of IL-6 alters the epidermal environment by decreasing the ability of
1362:
Much progress has been made in the understanding of the regulation of IL-17. At first, Aggarwal
5547:
4980:
4808:
4803:
3146:"Growth and cytogenetic characteristics of bone marrow colonies from patients with 5q-syndrome"
5153:
5138:
5102:
5072:
4818:
4368:
3987:
3853:
3600:
3565:
3516:
3470:
3419:
3362:
3319:
3237:
3202:
3167:
3126:
3083:
3048:
2992:
2948:
2894:
2844:
2784:
2736:
2670:
2621:
2567:
2536:
Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO, et al. (May 2006).
2515:
2471:
2412:
2371:
2330:
2307:
Yao Z, Painter SL, Fanslow WC, Ulrich D, Macduff BM, Spriggs MK, Armitage RJ (December 1995).
2278:
2235:
2183:
2137:
2083:
2027:
1992:
1951:
1910:
1861:
1826:
1782:
1741:
1468:. Furthermore, IL-17 bears no resemblance to any other known proteins or structural domains.
1244:
940:
100:
1339:. The expression of IL-17A and IL-17F appear to be restricted to a small group of activated
5991:
4680:
4601:
4469:
4158:
3992:
3592:
3555:
3547:
3506:
3460:
3450:
3409:
3401:
3388:
Ortiz ML, Kumar V, Martner A, Mony S, Donthireddy L, Condamine T, et al. (March 2015).
3354:
3311:
3229:
3194:
3157:
3118:
3075:
3038:
3030:
2982:
2938:
2930:
2919:"Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis"
2886:
2834:
2826:
2776:
2726:
2718:
2660:
2613:
2557:
2505:
2461:
2451:
2402:
2361:
2320:
2270:
2225:
2173:
2127:
2073:
2065:
2019:
1982:
1941:
1900:
1853:
1818:
1772:
1764:
1670:
1599:
1581:
1558:
1424:
1386:, plays an important role in IL-17 production. In the absence of SOCS3, IL-23-induced STAT3
1284:
1268:
1248:
981:
818:
809:
662:
525:
389:
380:
235:
5467:
5463:
5459:
2969:
Nakajima K, Kanda T, Takaishi M, Shiga T, Miyoshi K, Nakajima H, et al. (April 2011).
2308:
1888:
1499:
Recent work suggests the IL-23/IL-17 pathway plays a major role in the autoimmune disorder
1155:
1151:
1147:
92:
5783:
4207:
3893:
3583:
Ley K, Smith E, Stark MA (2006). "IL-17A-producing neutrophil-regulatory Tn lymphocytes".
3233:
2873:
Mudigonda P, Mudigonda T, Feneran AN, Alamdari HS, Sandoval L, Feldman SR (October 2012).
2722:
2390:
2010:
Miossec P, Korn T, Kuchroo VK (August 2009). "Interleukin-17 and type 17 helper T cells".
1387:
1356:
1336:
1233:
1010:
838:
691:
671:
554:
534:
409:
264:
2917:
Lin AM, Rubin CJ, Khandpur R, Wang JY, Riblett M, Yalavarthi S, et al. (July 2011).
1929:
990:
244:
2875:"Interleukin-23 and interleukin-17: importance in pathogenesis and therapy of psoriasis"
2772:
2609:
2553:
2447:
5981:
5971:
5966:
5952:
5938:
5928:
5923:
5870:
5852:
5831:
5810:
5789:
5775:
5749:
5693:
5661:
5625:
5588:
5583:
5578:
5542:
5537:
5430:
5384:
5333:
5302:
5281:
5016:
4985:
4721:
4716:
4571:
4549:
4544:
4347:
4342:
4332:
4327:
4322:
4317:
4312:
4308:
4277:
4272:
4267:
4246:
4241:
4236:
4231:
4186:
4181:
4176:
4171:
4119:
4104:
4095:
3652:
3560:
3535:
3465:
3438:
3414:
3389:
3043:
3018:
2943:
2918:
2839:
2814:
2731:
2706:
2466:
2431:
2430:
Chen Z, Laurence A, Kanno Y, Pacher-Zavisin M, Zhu BM, Tato C, et al. (May 2006).
2078:
2053:
1751:
Hymowitz SG, Filvaroff EH, Yin JP, Lee J, Cai L, Risser P, et al. (October 2001).
1526:
1461:
1452:
1367:
1352:
1260:
1229:
1167:
1055:
1047:
737:
3315:
1822:
1777:
1752:
6015:
5723:
5379:
5245:
5204:
5128:
5062:
5011:
4965:
4904:
4789:
4711:
4706:
4701:
4647:
4596:
4262:
4166:
4142:
4137:
4114:
4109:
4100:
4091:
3873:
3551:
3079:
2780:
1873:
1857:
1569:
1538:
1534:
1456:
1444:
1408:
1272:
1252:
1225:
1209:
1197:
1127:
1084:(see below). IL17A protein exhibits a high homology with a viral IL-17-like protein (
3612:
3374:
3358:
3331:
3095:
2796:
2432:"Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells"
2290:
2274:
2247:
2195:
54:
5897:
5718:
5404:
5399:
5394:
5143:
5082:
5041:
4192:
4024:
2682:
2633:
2579:
1706:
1522:
1476:
1472:
1448:
1371:
1348:
1344:
1091:
1081:
1040:
88:
4736:
1196:
allergic responses. IL-17 induces the production of many other cytokines (such as
2510:
2493:
2325:
2132:
2115:
1905:
957:
785:
638:
501:
356:
211:
66:
5728:
5708:
5671:
5506:
5496:
5348:
5343:
5178:
5148:
5087:
4929:
4889:
4848:
4843:
4613:
4559:
4300:
4059:
3982:
3162:
3145:
3122:
2407:
1643:
1631:
1627:
1511:
1480:
1465:
1256:
1240:
1020:
848:
701:
564:
419:
274:
3511:
3494:
3034:
2830:
2665:
2648:
2436:
Proceedings of the
National Academy of Sciences of the United States of America
1946:
1768:
5713:
5703:
5598:
5491:
5486:
5307:
5168:
5158:
5092:
5026:
4939:
4934:
4863:
4666:
4359:
4049:
4009:
3596:
2492:
Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B (February 2006).
1710:
1646:
can also be used to effectively treat psoriasis by indirectly reducing IL-17.
1542:
1221:
1119:
1051:
964:
792:
645:
508:
363:
218:
2987:
2970:
2934:
5183:
5173:
5163:
5036:
3671:
3621:
3455:
2456:
1658:
1619:
1554:
1530:
1500:
1440:
1332:
1308:
1304:
1131:
1073:
3604:
3569:
3520:
3474:
3423:
3366:
3323:
3130:
3087:
3052:
2996:
2952:
2898:
2874:
2848:
2788:
2740:
2674:
2625:
2571:
2538:"Transforming growth factor-beta induces development of the T(H)17 lineage"
2519:
2475:
2416:
2389:
Cho ML, Kang JW, Moon YM, Nam HJ, Jhun JY, Heo SB, et al. (May 2006).
2375:
2366:
2349:
2282:
2230:
2213:
2187:
2141:
2087:
2031:
1996:
1955:
1865:
1830:
1786:
1529:(DC). Cytokines released from DCs stimulate dying keratinocytes to secrete
3241:
3206:
3171:
2334:
2239:
2023:
1914:
1102:
The biologically active IL-17 interacts with type I cell surface receptor
4823:
4661:
3656:
3405:
2348:
Aggarwal S, Ghilardi N, Xie MH, de
Sauvage FJ, Gurney AL (January 2003).
2069:
1987:
1970:
1718:
1404:
1375:
1217:
1213:
1175:
1086:
1043:
969:
797:
650:
513:
368:
223:
61:
2617:
2562:
2537:
5942:
5425:
2890:
2178:
2161:
1546:
1340:
1171:
869:
21:
This article is about the protein family. For its founding member, see
3198:
1745:
1178:
residues. These conserved cysteine residues are critical to the right
1106:. In turn, there are at least three variants of IL-17R referred to as
945:
5557:
4539:
4436:
4431:
4426:
4421:
4416:
4411:
4129:
3934:
3918:
3913:
3908:
3903:
3898:
3888:
3883:
1887:
Rouvier E, Luciani MF, Mattéi MG, Denizot F, Golstein P (June 1993).
1595:
1484:
1420:
1412:
1296:
1205:
1184:
1115:
1111:
1107:
1070:
1067:
952:
780:
633:
496:
351:
206:
120:
5864:
5860:
5856:
5475:
5471:
5455:
4575:
4534:
4529:
4524:
4519:
4514:
4451:
4441:
4406:
4401:
4396:
4391:
4386:
4381:
4034:
4029:
4019:
4004:
3999:
3878:
3868:
3863:
3858:
3848:
3843:
3837:
3821:
3811:
3806:
3801:
3796:
3791:
3786:
3781:
3776:
3770:
3765:
3760:
3755:
3750:
3745:
3740:
3735:
3493:
Kawaguchi M, Adachi M, Oda N, Kokubu F, Huang SK (December 2004).
1662:
1577:
1573:
1383:
1359:
and IL-17E is found at low levels in various peripheral tissues.
1201:
1163:
1159:
1143:
155:
140:
22:
1464:. IL-17 is unique in that it bears no resemblance to other known
1174:
structure. Their protein sequences contain four highly conserved
4499:
4446:
4014:
3955:
3950:
3730:
3725:
3720:
3715:
3709:
3703:
3697:
3691:
3686:
1702:
1328:
933:
773:
626:
489:
344:
199:
82:
49:
4740:
3625:
5932:
3144:
Carbonell F, Heimpel H, Kubanek B, Fliedner TM (August 1985).
1280:
2214:"T. Duckett Jones and his association with Paul Dudley White"
1928:
Starnes T, Broxmeyer HE, Robertson MJ, Hromas R (July 2002).
3534:
Pappu R, Ramirez-Carrozzi V, Sambandam A (September 2011).
1271:
in mice) to induce expression of antimicrobial peptide by
1557:
to the epidermis. These cells release IL-23 which induce
2162:"IL-17: prototype member of an emerging cytokine family"
1661:
has been found to 'severely impair' production of the
1431:, directs differentiation of IL-17-producing T cells.
1099:. In rodents, IL-17A is often referred to as CTLA8.
1058:. Originally, Th17 was identified in 1993 by Rouvier
2309:"Human IL-17: a novel cytokine derived from T cells"
5916:
5896:
5889:
5840:
5819:
5798:
5758:
5737:
5681:
5649:
5608:
5566:
5520:
5439:
5413:
5357:
5316:
5290:
5264:
5233:
5213:
5192:
5111:
5050:
4994:
4948:
4872:
4777:
4631:
4589:
4558:
4486:
4460:
4367:
4358:
4299:
4290:
4255:
4218:
4156:
4128:
4082:
4067:
4058:
3968:
3943:
3927:
3830:
3679:
3670:
3663:
1390:is enhanced, and phosphorylated STAT3 binds to the
1016:
1006:
1001:
980:
975:
963:
951:
939:
927:
915:
903:
895:
887:
882:
862:
844:
834:
829:
808:
803:
791:
779:
767:
755:
743:
733:
725:
720:
715:
697:
687:
682:
661:
656:
644:
632:
620:
608:
596:
588:
583:
578:
560:
550:
545:
524:
519:
507:
495:
483:
471:
459:
451:
443:
438:
433:
415:
405:
400:
379:
374:
362:
350:
338:
326:
314:
306:
298:
293:
288:
270:
260:
255:
234:
229:
217:
205:
193:
181:
169:
161:
151:
146:
139:
119:
99:
81:
76:
60:
48:
40:
35:
30:
1170:. All members of the IL-17 family have a similar
2868:
2866:
2864:
2862:
2860:
2858:
1366:showed that production of IL-17 was dependent on
3488:
3486:
3484:
2964:
2962:
2116:"Interleukin-17 family members and inflammation"
3258:. U.S. Food and Drug Administration. 2015-01-21
3012:
3010:
3008:
3006:
2808:
2806:
2705:Lowes MA, Suárez-Fariñas M, Krueger JG (2014).
2591:
2589:
2487:
2485:
1626:. In January 2015, the FDA approved the use of
1439:IL-17(A) is a 155-amino acid protein that is a
3499:The Journal of Allergy and Clinical Immunology
3023:The Journal of Allergy and Clinical Immunology
2813:Baliwag J, Barnes DH, Johnston A (June 2015).
1804:
1802:
1800:
1798:
1796:
1736:
1734:
4752:
3637:
2700:
2698:
2696:
2694:
2692:
2531:
2529:
2207:
2205:
2047:
2045:
2043:
2041:
1307:rejection, anti-tumour immunity and recently
8:
1479:fold is characterized by two sets of paired
3437:Chang SH, Chung Y, Dong C (December 2010).
2912:
2910:
2908:
2109:
2107:
2105:
2103:
2101:
2099:
2097:
5893:
4759:
4745:
4737:
4364:
4296:
4079:
4064:
3676:
3667:
3644:
3630:
3622:
3256:"FDA approves new psoriasis drug Cosentyx"
2761:Annals of the New York Academy of Sciences
2754:
2752:
2750:
2302:
2300:
2155:
2153:
2151:
1090:) encoded in the genome of T-lymphotropic
998:
868:
826:
679:
542:
397:
252:
73:
3559:
3510:
3464:
3454:
3413:
3279:. Novartis AG. 2014-12-26. Archived from
3161:
3111:Inflammation & Allergy - Drug Targets
3042:
2986:
2942:
2838:
2730:
2664:
2561:
2509:
2465:
2455:
2406:
2365:
2324:
2229:
2212:Paul O, Bland EF, Massell BF (May 1990).
2177:
2131:
2077:
1986:
1945:
1904:
1776:
5924:Interleukin 14 (taxilin alpha, HMW-BCGF)
2058:The Journal of Investigative Dermatology
1975:The Journal of Investigative Dermatology
1370:. Later, a Korean group discovered that
1146:(sometimes confusingly called "IL-17"),
1730:
5222:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
3347:Neuroscience and Biobehavioral Reviews
2160:Aggarwal S, Gurney AL (January 2002).
1054:in response to their stimulation with
859:
712:
575:
430:
285:
136:
27:
3234:10.1093/oxfordjournals.humrep.a136569
2723:10.1146/annurev-immunol-032713-120225
1142:The IL-17 family in humans comprises
7:
3394:The Journal of Experimental Medicine
1811:Cytokine & Growth Factor Reviews
1516:12-O-tetradecanoylphorbol-13-acetate
3443:The Journal of Biological Chemistry
2354:The Journal of Biological Chemistry
2114:Kolls JK, Lindén A (October 2004).
2012:The New England Journal of Medicine
1666:
3187:Acta Genetica et Statistica Medica
1846:The British Journal of Dermatology
1046:. They are produced by a group of
1039:) is a family of pro-inflammatory
14:
3552:10.1111/j.1365-2567.2011.03465.x
3080:10.1111/j.1600-0625.2012.01459.x
2781:10.1111/j.1749-6632.2010.05825.x
1858:10.1111/j.1365-2133.2008.08902.x
5750:Interleukin 27 (interleukin 30)
3359:10.1016/j.neubiorev.2013.01.021
2275:10.1016/j.pneurobio.2019.03.003
1491:(NGF) and other neurotrophins.
1403:by distinct cytokines, called
1382:showed that another molecule,
1:
3316:10.1016/S0140-6736(08)60725-4
1823:10.1016/S1359-6101(03)00002-9
77:Available protein structures:
6042:Genes on human chromosome 14
6037:Genes on human chromosome 13
6032:Genes on human chromosome 16
2511:10.1016/j.immuni.2006.01.001
2326:10.4049/jimmunol.155.12.5483
2166:Journal of Leukocyte Biology
2133:10.1016/j.immuni.2004.08.018
1906:10.4049/jimmunol.150.12.5445
6027:Genes on human chromosome 5
6022:Genes on human chromosome 6
5100:Antisense oligonucleotides:
3163:10.1182/blood.V66.2.463.463
3123:10.2174/1871528110908050383
2711:Annual Review of Immunology
2408:10.4049/jimmunol.176.9.5652
1580:to control the behavior of
6063:
3512:10.1016/j.jaci.2004.10.019
3035:10.1016/j.jaci.2012.04.024
2879:Dermatology Online Journal
2831:10.1016/j.cyto.2014.12.014
2666:10.1016/j.cell.2006.07.035
1947:10.4049/jimmunol.169.2.642
1680:
1642:. The anti-IL-23 antibody
1624:inflammatory bowel disease
1600:MAP kinase-related pathway
1166:. IL-17E is also known as
875:Crystallographic structure
20:
4607:Colony-stimulating factor
3505:(6): 1265–73, quiz 1274.
2707:"Immunology of psoriasis"
1343:, and upregulated during
1331:for human IL-17A is 1874
1239:) from many cell types (
1228:, GRO-α, and MCP-1), and
1076:. The protein encoded by
997:
867:
825:
678:
541:
396:
251:
72:
4642:proinflammatory cytokine
3068:Experimental Dermatology
2988:10.4049/jimmunol.1000148
2935:10.4049/jimmunol.1100123
2815:"Cytokines in psoriasis"
2263:Progress in Neurobiology
1769:10.1093/emboj/20.19.5332
1561:cells to produce IL-17.
1317:intracerebral hemorrhage
1267:cells in humans, but by
1080:is a founding member of
877:of dimeric human IL-17f.
5790:Interleukin-29 (IFN-λ1)
4935:Daclizumab (dacliximab)
4920:Tucotuzumab celmoleukin
3495:"IL-17 cytokine family"
3456:10.1074/jbc.C110.185777
2457:10.1073/pnas.0600666103
1683:Interleukin-17 receptor
1634:), an IL-17 inhibiting
5771:Interferon λ4 (IFN-λ4)
4864:Rilonacept (IL-1 Trap)
3773:/PARC/DCCK1/AMAC1/MIP4
2367:10.1074/jbc.M207577200
2231:10.1002/clc.4960130511
1566:antimicrobial peptides
5694:Interleukin 23 (SGRF)
5375:Cintredekin besudotox
5303:Interleukin 11 (AGIF)
5282:Interleukin 10 (CSIF)
2975:Journal of Immunology
2923:Journal of Immunology
2395:Journal of Immunology
2313:Journal of Immunology
2024:10.1056/NEJMra0707449
1934:Journal of Immunology
1893:Journal of Immunology
1508:monoclonal antibodies
1124:tumor necrosis factor
1033:Interleukin 17 family
31:Interleukin 17 family
4768:Interleukin receptor
3585:Immunologic Research
3406:10.1084/jem.20140835
2070:10.1038/jid.2012.194
1988:10.1038/jid.2010.340
1616:rheumatoid arthritis
1551:natural killer cells
1293:rheumatoid arthritis
1263:(produced mainly by
4900:Denileukin diftitox
4338:Interferon type III
3597:10.1385/IR:34:3:229
2773:2011NYASA1217...60H
2618:10.1038/nature04753
2610:2006Natur.441..235B
2563:10.1038/nature04754
2554:2006Natur.441..231M
2448:2006PNAS..103.8137C
2218:Clinical Cardiology
1657:The active form of
1640:psoriatic arthritis
1636:monoclonal antibody
1612:autoimmune diseases
1489:nerve growth factor
1415:. Recently, Ivanov
1259:). IL-17 acts with
1096:Herpesvirus saimiri
1062:who isolated IL17A
5472:E (interleukin 25)
3222:Human Reproduction
2891:10.5070/D33N39N8XM
2179:10.1189/jlb.71.1.1
1694:alternate splicing
1652:multiple sclerosis
1606:Therapeutic target
1578:T regulatory cells
1313:multiple sclerosis
6009:
6008:
6005:
6004:
5974:(signals through
5955:(signals through
5941:(signals through
5931:(signals through
5555:Binding proteins:
4885:Adargileukin alfa
4734:
4733:
4627:
4626:
4585:
4584:
4482:
4481:
4478:
4477:
4286:
4285:
3964:
3963:
3310:(9625): 1665–74.
3199:10.1159/000152104
1495:Role in psoriasis
1283:+ T-Cells called
1245:endothelial cells
1030:
1029:
1026:
1025:
858:
857:
854:
853:
711:
710:
707:
706:
574:
573:
570:
569:
429:
428:
425:
424:
284:
283:
280:
279:
135:
134:
131:
130:
126:structure summary
18:Group of proteins
6054:
5997:Efineptakin alfa
5992:Efavaleukin alfa
5894:
4861:Decoy receptors:
4761:
4754:
4747:
4738:
4365:
4297:
4080:
4065:
3677:
3668:
3646:
3639:
3632:
3623:
3617:
3616:
3580:
3574:
3573:
3563:
3531:
3525:
3524:
3514:
3490:
3479:
3478:
3468:
3458:
3434:
3428:
3427:
3417:
3385:
3379:
3378:
3342:
3336:
3335:
3298:
3292:
3291:
3289:
3288:
3273:
3267:
3266:
3264:
3263:
3252:
3246:
3245:
3217:
3211:
3210:
3182:
3176:
3175:
3165:
3141:
3135:
3134:
3106:
3100:
3099:
3063:
3057:
3056:
3046:
3029:(1): 145–54.e9.
3014:
3001:
3000:
2990:
2966:
2957:
2956:
2946:
2914:
2903:
2902:
2870:
2853:
2852:
2842:
2810:
2801:
2800:
2756:
2745:
2744:
2734:
2702:
2687:
2686:
2668:
2644:
2638:
2637:
2593:
2584:
2583:
2565:
2533:
2524:
2523:
2513:
2489:
2480:
2479:
2469:
2459:
2427:
2421:
2420:
2410:
2386:
2380:
2379:
2369:
2345:
2339:
2338:
2328:
2304:
2295:
2294:
2258:
2252:
2251:
2233:
2209:
2200:
2199:
2181:
2157:
2146:
2145:
2135:
2111:
2092:
2091:
2081:
2049:
2036:
2035:
2007:
2001:
2000:
1990:
1966:
1960:
1959:
1949:
1925:
1919:
1918:
1908:
1884:
1878:
1877:
1841:
1835:
1834:
1806:
1791:
1790:
1780:
1757:The EMBO Journal
1748:
1738:
1425:nuclear receptor
1269:T helper 17 cell
1249:epithelial cells
1089:
1052:T helper 17 cell
999:
872:
860:
827:
713:
680:
576:
543:
431:
398:
286:
253:
137:
74:
28:
6062:
6061:
6057:
6056:
6055:
6053:
6052:
6051:
6012:
6011:
6010:
6001:
5912:
5885:
5836:
5815:
5794:
5754:
5733:
5677:
5674:(against IL-22)
5645:
5604:
5601:(against IL-20)
5562:
5516:
5435:
5409:
5353:
5312:
5286:
5260:
5229:
5209:
5188:
5107:
5046:
4990:
4944:
4868:
4773:
4765:
4735:
4730:
4696:
4675:
4633:
4623:
4581:
4554:
4474:
4456:
4354:
4282:
4251:
4214:
4152:
4124:
4075:
4073:
4071:
4054:
3960:
3939:
3923:
3826:
3659:
3650:
3620:
3582:
3581:
3577:
3533:
3532:
3528:
3492:
3491:
3482:
3449:(50): 38751–5.
3436:
3435:
3431:
3387:
3386:
3382:
3344:
3343:
3339:
3300:
3299:
3295:
3286:
3284:
3275:
3274:
3270:
3261:
3259:
3254:
3253:
3249:
3219:
3218:
3214:
3184:
3183:
3179:
3143:
3142:
3138:
3108:
3107:
3103:
3065:
3064:
3060:
3016:
3015:
3004:
2968:
2967:
2960:
2916:
2915:
2906:
2872:
2871:
2856:
2812:
2811:
2804:
2758:
2757:
2748:
2704:
2703:
2690:
2646:
2645:
2641:
2604:(7090): 235–8.
2595:
2594:
2587:
2548:(7090): 231–4.
2535:
2534:
2527:
2491:
2490:
2483:
2442:(21): 8137–42.
2429:
2428:
2424:
2388:
2387:
2383:
2347:
2346:
2342:
2306:
2305:
2298:
2260:
2259:
2255:
2211:
2210:
2203:
2159:
2158:
2149:
2113:
2112:
2095:
2051:
2050:
2039:
2009:
2008:
2004:
1968:
1967:
1963:
1927:
1926:
1922:
1899:(12): 5445–56.
1886:
1885:
1881:
1843:
1842:
1838:
1808:
1807:
1794:
1763:(19): 5332–41.
1750:
1740:
1739:
1732:
1728:
1685:
1679:
1608:
1591:
1541:leading to the
1527:dendritic cells
1497:
1462:disulfide bonds
1437:
1419:found that the
1388:phosphorylation
1357:skeletal muscle
1325:
1323:Gene expression
1290:
1238:
1193:
1140:
1085:
878:
863:Interleukin 17F
716:Interleukin 17E
579:Interleukin 17D
434:Interleukin 17C
289:Interleukin 17B
141:Interleukin 17A
26:
19:
12:
11:
5:
6060:
6058:
6050:
6049:
6044:
6039:
6034:
6029:
6024:
6014:
6013:
6007:
6006:
6003:
6002:
6000:
5999:
5994:
5985:
5984:
5982:Interleukin 35
5979:
5972:Interleukin 34
5969:
5967:Interleukin 32
5964:
5953:Interleukin 26
5950:
5939:Interleukin 24
5936:
5929:Interleukin 16
5926:
5920:
5918:
5914:
5913:
5911:
5910:
5902:
5900:
5891:
5887:
5886:
5884:
5883:
5874:
5873:
5871:Interleukin 38
5868:
5853:Interleukin 36
5846:
5844:
5838:
5837:
5835:
5834:
5832:Interleukin 33
5825:
5823:
5817:
5816:
5814:
5813:
5811:Interleukin 31
5804:
5802:
5796:
5795:
5793:
5792:
5787:
5776:Interleukin 28
5773:
5764:
5762:
5756:
5755:
5753:
5752:
5743:
5741:
5735:
5734:
5732:
5731:
5726:
5721:
5716:
5711:
5706:
5697:
5696:
5687:
5685:
5679:
5678:
5676:
5675:
5665:
5664:
5662:Interleukin 22
5655:
5653:
5647:
5646:
5644:
5643:
5638:
5629:
5628:
5626:Interleukin 21
5623:
5614:
5612:
5606:
5605:
5603:
5602:
5592:
5591:
5589:Interleukin 24
5586:
5584:Interleukin 20
5581:
5579:Interleukin 19
5572:
5570:
5564:
5563:
5561:
5560:
5551:
5550:
5545:
5543:Interleukin 37
5540:
5538:Interleukin 18
5535:
5526:
5524:
5518:
5517:
5515:
5514:
5509:
5504:
5499:
5494:
5489:
5480:
5479:
5452:Interleukin 17
5445:
5443:
5437:
5436:
5434:
5433:
5431:Interleukin 15
5428:
5419:
5417:
5411:
5410:
5408:
5407:
5402:
5397:
5388:
5387:
5385:Interleukin 13
5382:
5377:
5372:
5363:
5361:
5355:
5354:
5352:
5351:
5346:
5337:
5336:
5334:Interleukin 12
5331:
5322:
5320:
5314:
5313:
5311:
5310:
5305:
5296:
5294:
5288:
5287:
5285:
5284:
5279:
5270:
5268:
5262:
5261:
5259:
5258:
5249:
5248:
5239:
5237:
5231:
5230:
5228:
5227:
5219:
5217:
5211:
5210:
5208:
5207:
5198:
5196:
5190:
5189:
5187:
5186:
5181:
5176:
5171:
5166:
5161:
5156:
5151:
5146:
5141:
5132:
5131:
5126:
5117:
5115:
5109:
5108:
5106:
5105:
5096:
5095:
5090:
5085:
5076:
5075:
5066:
5065:
5056:
5054:
5048:
5047:
5045:
5044:
5039:
5030:
5029:
5020:
5019:
5017:Interleukin 13
5014:
5009:
5000:
4998:
4992:
4991:
4989:
4988:
4986:Promegapoietin
4983:
4978:
4973:
4968:
4963:
4954:
4952:
4946:
4945:
4943:
4942:
4937:
4932:
4923:
4922:
4917:
4912:
4910:Pegaldesleukin
4907:
4902:
4897:
4892:
4887:
4878:
4876:
4870:
4869:
4867:
4866:
4857:
4856:
4851:
4846:
4837:
4836:
4831:
4826:
4821:
4812:
4811:
4806:
4801:
4783:
4781:
4775:
4774:
4766:
4764:
4763:
4756:
4749:
4741:
4732:
4731:
4729:
4728:
4727:
4726:
4725:
4724:
4719:
4714:
4709:
4704:
4694:
4690:
4689:
4688:
4683:
4673:
4664:
4658:
4657:
4656:
4655:
4650:
4637:
4635:
4629:
4628:
4625:
4624:
4622:
4621:
4616:
4611:
4610:
4609:
4604:
4593:
4591:
4587:
4586:
4583:
4582:
4580:
4579:
4564:
4562:
4556:
4555:
4553:
4552:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4512:
4507:
4502:
4492:
4490:
4488:Ig superfamily
4484:
4483:
4480:
4479:
4476:
4475:
4473:
4472:
4466:
4464:
4458:
4457:
4455:
4454:
4449:
4444:
4439:
4434:
4429:
4424:
4419:
4414:
4409:
4404:
4399:
4394:
4389:
4384:
4379:
4373:
4371:
4362:
4356:
4355:
4353:
4352:
4351:
4350:
4345:
4335:
4330:
4325:
4320:
4315:
4305:
4303:
4294:
4288:
4287:
4284:
4283:
4281:
4280:
4275:
4270:
4265:
4259:
4257:
4253:
4252:
4250:
4249:
4244:
4239:
4234:
4228:
4226:
4216:
4215:
4213:
4212:
4211:
4210:
4205:
4200:
4195:
4184:
4179:
4174:
4169:
4163:
4161:
4154:
4153:
4151:
4150:
4145:
4140:
4134:
4132:
4126:
4125:
4123:
4122:
4117:
4112:
4107:
4098:
4088:
4086:
4077:
4062:
4056:
4055:
4053:
4052:
4047:
4042:
4037:
4032:
4027:
4022:
4017:
4012:
4007:
4002:
3997:
3996:
3995:
3990:
3980:
3974:
3972:
3966:
3965:
3962:
3961:
3959:
3958:
3953:
3947:
3945:
3941:
3940:
3938:
3937:
3931:
3929:
3925:
3924:
3922:
3921:
3916:
3911:
3906:
3901:
3896:
3891:
3886:
3881:
3876:
3871:
3866:
3861:
3856:
3851:
3846:
3841:
3834:
3832:
3828:
3827:
3825:
3824:
3819:
3814:
3809:
3804:
3799:
3794:
3789:
3784:
3779:
3774:
3768:
3763:
3758:
3753:
3748:
3743:
3738:
3733:
3728:
3723:
3718:
3713:
3707:
3701:
3695:
3689:
3683:
3681:
3674:
3665:
3661:
3660:
3653:Cell signaling
3651:
3649:
3648:
3641:
3634:
3626:
3619:
3618:
3575:
3526:
3480:
3429:
3380:
3337:
3293:
3268:
3247:
3212:
3177:
3136:
3101:
3058:
3002:
2958:
2929:(1): 490–500.
2904:
2854:
2802:
2746:
2688:
2659:(6): 1121–33.
2639:
2585:
2525:
2481:
2422:
2401:(9): 5652–61.
2381:
2340:
2319:(12): 5483–6.
2296:
2253:
2201:
2147:
2093:
2037:
2002:
1961:
1920:
1879:
1836:
1792:
1729:
1727:
1724:
1678:
1675:
1607:
1604:
1590:
1589:Role in asthma
1587:
1496:
1493:
1453:signal peptide
1436:
1433:
1353:nervous system
1324:
1321:
1288:
1236:
1230:prostaglandins
1192:
1189:
1139:
1138:Family members
1136:
1028:
1027:
1024:
1023:
1018:
1014:
1013:
1008:
1004:
1003:
995:
994:
984:
978:
977:
973:
972:
967:
961:
960:
955:
949:
948:
943:
937:
936:
931:
925:
924:
919:
913:
912:
907:
901:
900:
897:
893:
892:
889:
885:
884:
880:
879:
873:
865:
864:
856:
855:
852:
851:
846:
842:
841:
836:
832:
831:
823:
822:
812:
806:
805:
801:
800:
795:
789:
788:
783:
777:
776:
771:
765:
764:
759:
753:
752:
747:
741:
740:
735:
731:
730:
727:
723:
722:
718:
717:
709:
708:
705:
704:
699:
695:
694:
689:
685:
684:
676:
675:
665:
659:
658:
654:
653:
648:
642:
641:
636:
630:
629:
624:
618:
617:
612:
606:
605:
600:
594:
593:
590:
586:
585:
581:
580:
572:
571:
568:
567:
562:
558:
557:
552:
548:
547:
539:
538:
528:
522:
521:
517:
516:
511:
505:
504:
499:
493:
492:
487:
481:
480:
475:
469:
468:
463:
457:
456:
453:
449:
448:
445:
441:
440:
436:
435:
427:
426:
423:
422:
417:
413:
412:
407:
403:
402:
394:
393:
383:
377:
376:
372:
371:
366:
360:
359:
354:
348:
347:
342:
336:
335:
330:
324:
323:
318:
312:
311:
308:
304:
303:
300:
296:
295:
291:
290:
282:
281:
278:
277:
272:
268:
267:
262:
258:
257:
249:
248:
238:
232:
231:
227:
226:
221:
215:
214:
209:
203:
202:
197:
191:
190:
185:
179:
178:
173:
167:
166:
163:
159:
158:
153:
149:
148:
144:
143:
133:
132:
129:
128:
123:
117:
116:
103:
97:
96:
86:
79:
78:
70:
69:
64:
58:
57:
52:
46:
45:
42:
38:
37:
33:
32:
17:
13:
10:
9:
6:
4:
3:
2:
6059:
6048:
6045:
6043:
6040:
6038:
6035:
6033:
6030:
6028:
6025:
6023:
6020:
6019:
6017:
5998:
5995:
5993:
5990:
5987:
5986:
5983:
5980:
5977:
5973:
5970:
5968:
5965:
5962:
5958:
5954:
5951:
5948:
5944:
5940:
5937:
5934:
5930:
5927:
5925:
5922:
5921:
5919:
5915:
5908:
5904:
5903:
5901:
5899:
5895:
5892:
5888:
5882:
5879:
5876:
5875:
5872:
5869:
5866:
5862:
5858:
5854:
5851:
5848:
5847:
5845:
5843:
5839:
5833:
5830:
5827:
5826:
5824:
5822:
5818:
5812:
5809:
5806:
5805:
5803:
5801:
5797:
5791:
5788:
5785:
5781:
5777:
5774:
5772:
5769:
5766:
5765:
5763:
5761:
5757:
5751:
5748:
5745:
5744:
5742:
5740:
5736:
5730:
5727:
5725:
5724:Tildrakizumab
5722:
5720:
5717:
5715:
5712:
5710:
5707:
5705:
5702:
5699:
5698:
5695:
5692:
5689:
5688:
5686:
5684:
5680:
5673:
5670:
5667:
5666:
5663:
5660:
5657:
5656:
5654:
5652:
5648:
5642:
5639:
5637:
5634:
5631:
5630:
5627:
5624:
5622:
5619:
5616:
5615:
5613:
5611:
5607:
5600:
5597:
5594:
5593:
5590:
5587:
5585:
5582:
5580:
5577:
5574:
5573:
5571:
5569:
5565:
5559:
5556:
5553:
5552:
5549:
5546:
5544:
5541:
5539:
5536:
5534:
5531:
5528:
5527:
5525:
5523:
5519:
5513:
5510:
5508:
5505:
5503:
5500:
5498:
5495:
5493:
5490:
5488:
5485:
5482:
5481:
5477:
5473:
5469:
5465:
5461:
5457:
5453:
5450:
5447:
5446:
5444:
5442:
5438:
5432:
5429:
5427:
5424:
5421:
5420:
5418:
5416:
5412:
5406:
5403:
5401:
5398:
5396:
5393:
5390:
5389:
5386:
5383:
5381:
5380:Interleukin 4
5378:
5376:
5373:
5371:
5368:
5365:
5364:
5362:
5360:
5356:
5350:
5347:
5345:
5342:
5339:
5338:
5335:
5332:
5330:
5329:Edodekin alfa
5327:
5324:
5323:
5321:
5319:
5315:
5309:
5306:
5304:
5301:
5298:
5297:
5295:
5293:
5289:
5283:
5280:
5278:
5275:
5272:
5271:
5269:
5267:
5263:
5257:
5254:
5251:
5250:
5247:
5246:Interleukin 9
5244:
5241:
5240:
5238:
5236:
5232:
5225:
5221:
5220:
5218:
5216:
5212:
5206:
5205:Interleukin 7
5203:
5200:
5199:
5197:
5195:
5191:
5185:
5182:
5180:
5177:
5175:
5172:
5170:
5167:
5165:
5162:
5160:
5157:
5155:
5152:
5150:
5147:
5145:
5142:
5140:
5137:
5134:
5133:
5130:
5129:Interleukin 6
5127:
5125:
5124:Atexakin alfa
5122:
5119:
5118:
5116:
5114:
5110:
5104:
5101:
5098:
5097:
5094:
5091:
5089:
5086:
5084:
5081:
5078:
5077:
5074:
5071:
5068:
5067:
5064:
5063:Interleukin 5
5061:
5058:
5057:
5055:
5053:
5049:
5043:
5040:
5038:
5035:
5032:
5031:
5028:
5025:
5022:
5021:
5018:
5015:
5013:
5012:Interleukin 4
5010:
5008:
5005:
5002:
5001:
4999:
4997:
4993:
4987:
4984:
4982:
4979:
4977:
4974:
4972:
4969:
4967:
4966:Interleukin 3
4964:
4962:
4959:
4956:
4955:
4953:
4951:
4947:
4941:
4938:
4936:
4933:
4931:
4928:
4925:
4924:
4921:
4918:
4916:
4913:
4911:
4908:
4906:
4905:Interleukin 2
4903:
4901:
4898:
4896:
4893:
4891:
4888:
4886:
4883:
4880:
4879:
4877:
4875:
4871:
4865:
4862:
4859:
4858:
4855:
4852:
4850:
4847:
4845:
4842:
4839:
4838:
4835:
4832:
4830:
4827:
4825:
4822:
4820:
4817:
4814:
4813:
4810:
4807:
4805:
4802:
4799:
4795:
4791:
4790:Interleukin 1
4788:
4785:
4784:
4782:
4780:
4776:
4772:
4769:
4762:
4757:
4755:
4750:
4748:
4743:
4742:
4739:
4723:
4720:
4718:
4715:
4713:
4710:
4708:
4705:
4703:
4700:
4699:
4698:
4691:
4687:
4684:
4682:
4679:
4678:
4677:
4670:
4669:
4668:
4665:
4663:
4660:
4659:
4654:
4651:
4649:
4646:
4645:
4644:
4643:
4639:
4638:
4636:
4630:
4620:
4617:
4615:
4612:
4608:
4605:
4603:
4600:
4599:
4598:
4597:Hematopoietic
4595:
4594:
4592:
4588:
4577:
4573:
4569:
4566:
4565:
4563:
4561:
4557:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4516:
4513:
4511:
4508:
4506:
4503:
4501:
4497:
4494:
4493:
4491:
4489:
4485:
4471:
4468:
4467:
4465:
4463:
4459:
4453:
4450:
4448:
4445:
4443:
4440:
4438:
4435:
4433:
4430:
4428:
4425:
4423:
4420:
4418:
4415:
4413:
4410:
4408:
4405:
4403:
4400:
4398:
4395:
4393:
4390:
4388:
4385:
4383:
4380:
4378:
4375:
4374:
4372:
4370:
4366:
4363:
4361:
4357:
4349:
4346:
4344:
4341:
4340:
4339:
4336:
4334:
4331:
4329:
4326:
4324:
4321:
4319:
4316:
4314:
4310:
4307:
4306:
4304:
4302:
4298:
4295:
4293:
4289:
4279:
4276:
4274:
4271:
4269:
4266:
4264:
4261:
4260:
4258:
4254:
4248:
4245:
4243:
4240:
4238:
4235:
4233:
4230:
4229:
4227:
4225:
4221:
4217:
4209:
4206:
4204:
4201:
4199:
4196:
4194:
4190:
4189:
4188:
4185:
4183:
4180:
4178:
4175:
4173:
4170:
4168:
4165:
4164:
4162:
4160:
4155:
4149:
4146:
4144:
4141:
4139:
4136:
4135:
4133:
4131:
4127:
4121:
4118:
4116:
4113:
4111:
4108:
4106:
4102:
4099:
4097:
4093:
4090:
4089:
4087:
4085:
4081:
4078:
4070:
4066:
4063:
4061:
4057:
4051:
4048:
4046:
4043:
4041:
4038:
4036:
4033:
4031:
4028:
4026:
4023:
4021:
4018:
4016:
4013:
4011:
4008:
4006:
4005:TNFSF5/CD40LG
4003:
4001:
3998:
3994:
3991:
3989:
3986:
3985:
3984:
3981:
3979:
3976:
3975:
3973:
3971:
3967:
3957:
3954:
3952:
3949:
3948:
3946:
3942:
3936:
3933:
3932:
3930:
3926:
3920:
3917:
3915:
3912:
3910:
3907:
3905:
3902:
3900:
3897:
3895:
3892:
3890:
3887:
3885:
3882:
3880:
3877:
3875:
3872:
3870:
3867:
3865:
3862:
3860:
3857:
3855:
3852:
3850:
3847:
3845:
3842:
3839:
3836:
3835:
3833:
3829:
3823:
3820:
3818:
3815:
3813:
3810:
3808:
3805:
3803:
3800:
3798:
3795:
3793:
3790:
3788:
3785:
3783:
3780:
3778:
3775:
3772:
3769:
3767:
3764:
3762:
3759:
3757:
3754:
3752:
3749:
3747:
3744:
3742:
3739:
3737:
3734:
3732:
3729:
3727:
3724:
3722:
3719:
3717:
3714:
3711:
3708:
3705:
3702:
3699:
3696:
3693:
3690:
3688:
3685:
3684:
3682:
3678:
3675:
3673:
3669:
3666:
3662:
3658:
3654:
3647:
3642:
3640:
3635:
3633:
3628:
3627:
3624:
3614:
3610:
3606:
3602:
3598:
3594:
3591:(3): 229–42.
3590:
3586:
3579:
3576:
3571:
3567:
3562:
3557:
3553:
3549:
3545:
3541:
3537:
3530:
3527:
3522:
3518:
3513:
3508:
3504:
3500:
3496:
3489:
3487:
3485:
3481:
3476:
3472:
3467:
3462:
3457:
3452:
3448:
3444:
3440:
3433:
3430:
3425:
3421:
3416:
3411:
3407:
3403:
3400:(3): 351–67.
3399:
3395:
3391:
3384:
3381:
3376:
3372:
3368:
3364:
3360:
3356:
3353:(3): 436–47.
3352:
3348:
3341:
3338:
3333:
3329:
3325:
3321:
3317:
3313:
3309:
3305:
3297:
3294:
3283:on 2015-03-25
3282:
3278:
3272:
3269:
3257:
3251:
3248:
3243:
3239:
3235:
3231:
3227:
3223:
3216:
3213:
3208:
3204:
3200:
3196:
3192:
3188:
3181:
3178:
3173:
3169:
3164:
3159:
3155:
3151:
3147:
3140:
3137:
3132:
3128:
3124:
3120:
3116:
3112:
3105:
3102:
3097:
3093:
3089:
3085:
3081:
3077:
3074:(5): 327–30.
3073:
3069:
3062:
3059:
3054:
3050:
3045:
3040:
3036:
3032:
3028:
3024:
3020:
3013:
3011:
3009:
3007:
3003:
2998:
2994:
2989:
2984:
2981:(7): 4481–9.
2980:
2976:
2972:
2965:
2963:
2959:
2954:
2950:
2945:
2940:
2936:
2932:
2928:
2924:
2920:
2913:
2911:
2909:
2905:
2900:
2896:
2892:
2888:
2884:
2880:
2876:
2869:
2867:
2865:
2863:
2861:
2859:
2855:
2850:
2846:
2841:
2836:
2832:
2828:
2825:(2): 342–50.
2824:
2820:
2816:
2809:
2807:
2803:
2798:
2794:
2790:
2786:
2782:
2778:
2774:
2770:
2766:
2762:
2755:
2753:
2751:
2747:
2742:
2738:
2733:
2728:
2724:
2720:
2716:
2712:
2708:
2701:
2699:
2697:
2695:
2693:
2689:
2684:
2680:
2676:
2672:
2667:
2662:
2658:
2654:
2650:
2643:
2640:
2635:
2631:
2627:
2623:
2619:
2615:
2611:
2607:
2603:
2599:
2592:
2590:
2586:
2581:
2577:
2573:
2569:
2564:
2559:
2555:
2551:
2547:
2543:
2539:
2532:
2530:
2526:
2521:
2517:
2512:
2507:
2504:(2): 179–89.
2503:
2499:
2495:
2488:
2486:
2482:
2477:
2473:
2468:
2463:
2458:
2453:
2449:
2445:
2441:
2437:
2433:
2426:
2423:
2418:
2414:
2409:
2404:
2400:
2396:
2392:
2385:
2382:
2377:
2373:
2368:
2363:
2360:(3): 1910–4.
2359:
2355:
2351:
2344:
2341:
2336:
2332:
2327:
2322:
2318:
2314:
2310:
2303:
2301:
2297:
2292:
2288:
2284:
2280:
2276:
2272:
2268:
2264:
2257:
2254:
2249:
2245:
2241:
2237:
2232:
2227:
2223:
2219:
2215:
2208:
2206:
2202:
2197:
2193:
2189:
2185:
2180:
2175:
2171:
2167:
2163:
2156:
2154:
2152:
2148:
2143:
2139:
2134:
2129:
2126:(4): 467–76.
2125:
2121:
2117:
2110:
2108:
2106:
2104:
2102:
2100:
2098:
2094:
2089:
2085:
2080:
2075:
2071:
2067:
2063:
2059:
2055:
2048:
2046:
2044:
2042:
2038:
2033:
2029:
2025:
2021:
2018:(9): 888–98.
2017:
2013:
2006:
2003:
1998:
1994:
1989:
1984:
1981:(3): 677–87.
1980:
1976:
1972:
1965:
1962:
1957:
1953:
1948:
1943:
1939:
1935:
1931:
1924:
1921:
1916:
1912:
1907:
1902:
1898:
1894:
1890:
1883:
1880:
1875:
1871:
1867:
1863:
1859:
1855:
1852:(2): 319–24.
1851:
1847:
1840:
1837:
1832:
1828:
1824:
1820:
1817:(2): 155–74.
1816:
1812:
1805:
1803:
1801:
1799:
1797:
1793:
1788:
1784:
1779:
1774:
1770:
1766:
1762:
1758:
1754:
1747:
1743:
1737:
1735:
1731:
1725:
1723:
1720:
1716:
1712:
1708:
1704:
1698:
1695:
1689:
1684:
1676:
1674:
1672:
1669:cytokines by
1668:
1664:
1660:
1655:
1653:
1647:
1645:
1641:
1637:
1633:
1629:
1625:
1621:
1617:
1613:
1605:
1603:
1601:
1597:
1588:
1586:
1583:
1579:
1575:
1571:
1567:
1562:
1560:
1556:
1552:
1548:
1544:
1540:
1536:
1532:
1528:
1524:
1519:
1517:
1513:
1509:
1504:
1502:
1494:
1492:
1490:
1486:
1482:
1478:
1474:
1473:neurotrophins
1469:
1467:
1463:
1458:
1457:glycosylation
1454:
1450:
1446:
1442:
1434:
1432:
1430:
1426:
1422:
1418:
1414:
1410:
1406:
1402:
1398:
1393:
1389:
1385:
1381:
1377:
1373:
1369:
1365:
1360:
1358:
1354:
1350:
1346:
1342:
1338:
1334:
1330:
1322:
1320:
1318:
1314:
1310:
1306:
1302:
1298:
1294:
1286:
1282:
1276:
1274:
1273:keratinocytes
1270:
1266:
1262:
1258:
1254:
1253:keratinocytes
1250:
1246:
1242:
1235:
1231:
1227:
1223:
1219:
1215:
1211:
1207:
1203:
1199:
1190:
1188:
1186:
1181:
1180:3-dimensional
1177:
1173:
1169:
1165:
1161:
1157:
1153:
1149:
1145:
1137:
1135:
1133:
1129:
1128:interleukin-1
1125:
1121:
1117:
1113:
1109:
1105:
1100:
1098:
1097:
1093:
1088:
1083:
1079:
1075:
1072:
1069:
1065:
1061:
1057:
1053:
1049:
1048:T helper cell
1045:
1042:
1038:
1034:
1022:
1019:
1015:
1012:
1009:
1005:
1000:
996:
993:
992:
988:
985:
983:
979:
974:
971:
968:
966:
962:
959:
956:
954:
950:
947:
944:
942:
938:
935:
932:
930:
926:
923:
920:
918:
914:
911:
908:
906:
902:
898:
894:
890:
886:
881:
876:
871:
866:
861:
850:
847:
843:
840:
837:
833:
828:
824:
821:
820:
816:
813:
811:
807:
802:
799:
796:
794:
790:
787:
784:
782:
778:
775:
772:
770:
766:
763:
760:
758:
754:
751:
748:
746:
742:
739:
736:
732:
728:
724:
719:
714:
703:
700:
696:
693:
690:
686:
681:
677:
674:
673:
669:
666:
664:
660:
655:
652:
649:
647:
643:
640:
637:
635:
631:
628:
625:
623:
619:
616:
613:
611:
607:
604:
601:
599:
595:
591:
587:
582:
577:
566:
563:
559:
556:
553:
549:
544:
540:
537:
536:
532:
529:
527:
523:
518:
515:
512:
510:
506:
503:
500:
498:
494:
491:
488:
486:
482:
479:
476:
474:
470:
467:
464:
462:
458:
454:
450:
446:
442:
437:
432:
421:
418:
414:
411:
408:
404:
399:
395:
392:
391:
387:
384:
382:
378:
373:
370:
367:
365:
361:
358:
355:
353:
349:
346:
343:
341:
337:
334:
331:
329:
325:
322:
319:
317:
313:
309:
305:
301:
297:
292:
287:
276:
273:
269:
266:
263:
259:
254:
250:
247:
246:
242:
239:
237:
233:
228:
225:
222:
220:
216:
213:
210:
208:
204:
201:
198:
196:
192:
189:
186:
184:
180:
177:
174:
172:
168:
164:
160:
157:
154:
150:
145:
142:
138:
127:
124:
122:
118:
115:
111:
107:
104:
102:
98:
94:
90:
87:
84:
80:
75:
71:
68:
65:
63:
59:
56:
53:
51:
47:
43:
39:
34:
29:
24:
16:
6047:Interleukins
5988:
5976:M-CSFR/CSF1R
5963:heterodimer)
5949:heterodimer)
5878:Antagonists:
5877:
5849:
5828:
5807:
5767:
5746:
5719:Risankizumab
5700:
5690:
5668:
5658:
5641:NNC0114-0006
5636:NNC0114-0005
5632:
5617:
5595:
5575:
5554:
5529:
5483:
5451:
5448:
5422:
5405:Tralokinumab
5400:Lebrikizumab
5395:Anrukinzumab
5391:
5366:
5340:
5325:
5299:
5273:
5252:
5242:
5201:
5144:Clazakizumab
5135:
5120:
5099:
5083:Benralizumab
5079:
5070:Antagonists:
5069:
5059:
5042:Pascolizumab
5033:
5024:Antagonists:
5023:
5003:
4957:
4926:
4881:
4860:
4840:
4816:Antagonists:
4815:
4786:
4692:
4671:
4640:
4632:By function/
4567:
4343:IL28/IFNL2+3
3588:
3584:
3578:
3543:
3539:
3529:
3502:
3498:
3446:
3442:
3432:
3397:
3393:
3383:
3350:
3346:
3340:
3307:
3303:
3296:
3285:. Retrieved
3281:the original
3271:
3260:. Retrieved
3250:
3228:(6): 453–5.
3225:
3221:
3215:
3193:(6): 511–7.
3190:
3186:
3180:
3156:(2): 463–5.
3153:
3149:
3139:
3117:(5): 383–9.
3114:
3110:
3104:
3071:
3067:
3061:
3026:
3022:
2978:
2974:
2926:
2922:
2882:
2878:
2822:
2818:
2767:(1): 60–76.
2764:
2760:
2714:
2710:
2656:
2652:
2642:
2601:
2597:
2545:
2541:
2501:
2497:
2439:
2435:
2425:
2398:
2394:
2384:
2357:
2353:
2343:
2316:
2312:
2266:
2262:
2256:
2224:(5): 367–9.
2221:
2217:
2169:
2165:
2123:
2119:
2064:(1): 17–26.
2061:
2057:
2015:
2011:
2005:
1978:
1974:
1964:
1940:(2): 642–6.
1937:
1933:
1923:
1896:
1892:
1882:
1849:
1845:
1839:
1814:
1810:
1760:
1756:
1699:
1690:
1686:
1656:
1648:
1630:(trade name
1609:
1592:
1563:
1523:keratinocyte
1520:
1505:
1498:
1477:cystine knot
1470:
1466:interleukins
1449:glycoprotein
1438:
1416:
1400:
1396:
1379:
1363:
1361:
1349:inflammatory
1345:inflammation
1326:
1277:
1194:
1141:
1101:
1094:
1092:rhadinovirus
1082:IL-17 family
1077:
1059:
1041:cystine knot
1036:
1032:
1031:
989:
896:Alt. symbols
817:
734:Alt. symbols
670:
533:
452:Alt. symbols
388:
307:Alt. symbols
243:
162:Alt. symbols
15:
5729:Ustekinumab
5709:Briakinumab
5701:Antibodies:
5672:Fezakinumab
5669:Antibodies:
5633:Antibodies:
5621:Denenicokin
5596:Antibodies:
5533:Iboctadekin
5512:Vunakizumab
5507:Secukinumab
5497:Perakizumab
5484:Antibodies:
5392:Antibodies:
5349:Ustekinumab
5344:Briakinumab
5341:Antibodies:
5253:Antibodies:
5179:Tocilizumab
5149:Elsilimomab
5136:Antibodies:
5088:Mepolizumab
5080:Antibodies:
5034:Antibodies:
4961:Daniplestim
4930:Basiliximab
4927:Antibodies:
4895:Celmoleukin
4890:Aldesleukin
4854:Lutikizumab
4849:Gevokizumab
4844:Canakinumab
4841:Antibodies:
4560:IL17 family
4301:IL10 family
4220:IL12 family
4072:(grouped by
4060:Interleukin
3983:Lymphotoxin
3546:(1): 8–16.
1644:ustekinumab
1628:secukinumab
1512:hyperplasia
1447:, secreted
1445:homodimeric
1285:T helper 17
1265:T helper 22
1257:macrophages
1241:fibroblasts
1224:(including
1037:IL17 family
1011:Swiss-model
883:Identifiers
839:Swiss-model
721:Identifiers
692:Swiss-model
584:Identifiers
555:Swiss-model
439:Identifiers
410:Swiss-model
294:Identifiers
265:Swiss-model
165:IL17, CTLA8
147:Identifiers
36:Identifiers
6016:Categories
5784:B (IFN-λ3)
5780:A (IFN-λ2)
5714:Guselkumab
5704:Brazikumab
5599:Fletikumab
5502:Remtolumab
5492:Ixekizumab
5487:Brodalumab
5370:Binetrakin
5308:Oprelvekin
5277:Ilodecakin
5256:Enokizumab
5169:Siltuximab
5159:Olokizumab
5093:Reslizumab
5027:Pitrakinra
5007:Binetrakin
4976:Milodistim
4971:Leridistim
4940:Inolimomab
4915:Teceleukin
4834:Isunakinra
4771:modulators
4667:Lymphokine
4505:IL1B/IL1F2
4500:IL1A/IL1F1
4496:IL1 family
4360:Interferon
4348:IL29/IFNL1
3540:Immunology
3287:2015-03-12
3262:2015-03-12
2717:: 227–55.
2269:: 101610.
2172:(1): 1–8.
1726:References
1681:See also:
1543:chemotaxis
1337:expression
1333:base pairs
1222:chemokines
1120:chemokines
1064:transcript
1007:Structures
1002:Search for
976:Other data
835:Structures
830:Search for
804:Other data
688:Structures
683:Search for
657:Other data
551:Structures
546:Search for
520:Other data
406:Structures
401:Search for
375:Other data
261:Structures
256:Search for
230:Other data
89:structures
5989:Unsorted:
5850:Agonists:
5829:Agonists:
5808:Agonists:
5768:Agonists:
5747:Agonists:
5691:Agonists:
5659:Agonists:
5618:Agonists:
5576:Agonists:
5548:Tadekinig
5530:Agonists:
5449:Agonists:
5423:Agonists:
5367:Agonists:
5326:Agonists:
5300:Agonists:
5274:Agonists:
5243:Agonists:
5202:Agonists:
5184:Levilimab
5174:Sirukumab
5164:Sarilumab
5121:Agonists:
5060:Agonists:
5037:Dupilumab
5004:Agonists:
4981:Muplestim
4958:Agonists:
4882:Agonists:
4809:Pifonakin
4804:Mobenakin
4787:Agonists:
4545:33/IL1F11
4510:1Ra/IL1F3
4157:IL6 like/
3874:CXCL8/IL8
3672:Chemokine
3664:By family
3657:cytokines
2885:(10): 1.
1874:205257996
1749:;
1677:Receptors
1659:vitamin D
1620:psoriasis
1555:monocytes
1531:TNF-alpha
1501:psoriasis
1481:β-strands
1443:-linked,
1441:disulfide
1435:Structure
1423:specific
1309:psoriasis
1305:allograft
1132:psoriasis
1074:hybridoma
1050:known as
1044:cytokines
958:NP_443104
905:NCBI gene
786:NP_073626
745:NCBI gene
639:NP_612141
598:NCBI gene
502:NP_037410
461:NCBI gene
357:NP_055258
316:NCBI gene
212:NP_002181
171:NCBI gene
67:IPR010345
44:IL-17_fam
5943:IL-22Rα1
5909:instead.
5226:instead.
5154:mAb 1339
5139:ARGX-109
5103:TPI ASM8
5073:YM-90709
4824:Anakinra
4819:AF-12198
4662:Monokine
4191:+non IL
4076:subunit)
4074:receptor
4045:TNFSF13B
3993:TNFC/LTB
3988:TNFB/LTA
3613:22008293
3605:16891673
3570:21726218
3521:15577820
3475:20974859
3424:25667306
3375:10722525
3367:23370232
3332:24055733
3324:18486739
3131:20025586
3096:24119451
3088:22509827
3053:22677045
2997:21346238
2953:21606249
2899:23122008
2849:25585875
2819:Cytokine
2797:20349222
2789:21155836
2741:24655295
2675:16990136
2626:16648838
2572:16648837
2520:16473830
2498:Immunity
2476:16698929
2417:16622035
2376:12417590
2291:85495400
2283:30923023
2248:45530740
2196:15271840
2188:11781375
2142:15485625
2120:Immunity
2088:22673731
2032:19710487
1997:21085185
1956:12097364
1866:19016708
1831:12651226
1787:11574464
1632:Cosentyx
1614:such as
1397:in vitro
1392:promoter
1191:Function
1176:cysteine
1021:InterPro
849:InterPro
702:InterPro
565:InterPro
420:InterPro
275:InterPro
106:RCSB PDB
62:InterPro
5961:IL-10Rβ
5957:IL-20Rα
5947:IL-20Rβ
5881:IL-36RA
5426:ALT-803
4550:18/IL1G
4292:Type II
4224:IL12RB1
4130:β chain
4084:γ chain
4040:TNFSF13
4035:TNFSF11
4030:TNFSF10
3712:/RANTES
3561:3173690
3466:2998156
3415:4354367
3242:3312283
3207:4168861
3172:4016279
3044:3470466
2944:3119764
2840:4437803
2769:Bibcode
2732:4229247
2683:9034013
2634:4391497
2606:Bibcode
2580:4379904
2550:Bibcode
2467:1459629
2444:Bibcode
2335:7499828
2240:2189615
2079:3568997
1915:8390535
1713:, p38,
1673:cells.
1547:T cells
1475:. The
1413:T-cells
1401:in vivo
1355:and in
1341:T cells
1232:(e.g.,
1185:mammals
1172:protein
1066:from a
1017:Domains
965:UniProt
845:Domains
815:Chr. 14
793:UniProt
698:Domains
668:Chr. 13
646:UniProt
561:Domains
531:Chr. 16
509:UniProt
416:Domains
364:UniProt
271:Domains
219:UniProt
55:PF06083
5917:Others
5890:Others
5842:IL1RL2
5821:IL1RL1
5558:IL18BP
4829:IL-1RA
4540:IL1F10
4437:IFNA21
4432:IFNA17
4427:IFNA16
4422:IFNA14
4417:IFNA13
4412:IFNA10
4069:Type I
4025:TNFSF9
4020:TNFSF8
4015:TNFSF7
4010:TNFSF6
4000:TNFSF4
3935:CX3CL1
3919:CXCL17
3914:CXCL16
3909:CXCL15
3904:CXCL14
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