228:
31:
669:
from a study where mice that were bred to be allergic to peanuts, interleukin-12 has been shown to not be present, suggesting that the molecule normally stops allergies to food from developing. Further investigation is underway, to determine whether the results found in mice are as profound in
583:
tested to this date. There is a link that may be useful in treatment between IL-12 and the diseases psoriasis & inflammatory bowel disease. There has also been research indicating that interleukin 12 is linked with interleukin 23 and antibodies against these factors have a possible role in
715:
deletion within the IL-12 p40 subunit gene, precluding expression of functional IL-12 p70 cytokine by activated dendritic cells and phagocytes. As a result, IFNγ production by the child's lymphocytes was markedly impaired. This suggested that IL-12 is essential for protective immunity to
575:). IP-10 then mediates this anti-angiogenic effect. Because of its ability to induce immune responses and its anti-angiogenic activity, there has been an interest in testing IL-12 as a possible anti-
2502:
737:
infections failed to produce IFNγ when stimulated with IL-12. The patients were otherwise healthy. They were found to have mutations in the IL-12 receptor β1 chain, resulting in
1240:
Altare F, Durandy A, Lammas D, Emile JF, Lamhamedi S, Le Deist F, et al. (May 1998). "Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency".
888:
Hsieh CS, Macatonia SE, Tripp CS, Wolf SF, O'Garra A, Murphy KM (April 1993). "Development of TH1 CD4+ T cells through IL-12 produced by
Listeria-induced macrophages".
1891:
2495:
1212:
Newport MJ, Holland SM, Levin M, Casanova JL (2007). "Inherited disorders of the interleukin-12/23-interferon gamma axis". In Ochs HD, Smith CI, Puck J (eds.).
259:
100:
1072:
794:"IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells"
548:
stimulates the expression of two IL-12 receptors, IL-12R-β1 and IL-12R-β2, maintaining the expression of a critical protein involved in IL-12 signaling in
1328:
Guenova E, Volz T, Sauer K, Kaesler S, Müller MR, Wölbing F, et al. (November 2008). "IL-4-mediated fine tuning of IL-12p70 production by human DC".
733:
for IL-12 is important for IFNγ production by lymphocytes. T and NK cells from seven unrelated patients who had severe idiopathic mycobacterial and
2488:
1967:
658:
was shown to worsen the autoimmune phenomena. This is believed to be due to its key role in induction of Th1 immune responses. In contrast, IL-12
597:
593:
3700:
2967:
2362:
1073:"Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4"
3704:
3690:
3650:
1221:
948:
3770:
3765:
3719:
1387:
283:
124:
741:
in the extracellular domain, resulting in unresponsiveness to this cytokine, again demonstrating IL-12's crucial role in host defense.
3624:
756:
gene, which were associated with lower production of interferon-γ, IL-17, and IL-22 in response to IL-12 or IL-23 receptor associated
497:. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of
414:) in response to antigenic stimulation. IL-12 belongs to the family of interleukin-12. IL-12 family is unique in comprising the only
2572:
2253:
745:
271:
112:
702:
1783:
264:
105:
3585:
3564:
1560:
430:. Despite sharing many structural features and molecular partners, they mediate surprisingly diverse functional effects.
419:
1100:
931:
Zheng H, Ban Y, Wei F, Ma X (2016), Ma X (ed.), "Regulation of
Interleukin-12 Production in Antigen-Presenting Cells",
2396:
1946:
1721:
502:
450:
219:
2429:
2231:
1941:
2350:
2035:
563:
activity, which means it can block the formation of new blood vessels. It does this by increasing production of
2385:
1812:
1788:
973:"The Expanding Role of Anti–IL-12 and/or Anti–IL-23 Antibodies in the Treatment of Inflammatory Bowel Disease"
639:
An extensive review and visualization of IL-12 signaling can be found at the peer-reviewed pathway database
612:
development. Upon binding, IL-12R-β2 becomes tyrosine phosphorylated and provides binding sites for kinases,
3543:
3503:
3482:
3426:
3394:
3353:
3311:
3265:
3184:
3158:
3102:
3061:
3035:
3009:
2663:
1380:
1283:
van de
Veerdonk FL, Plantinga TS, Hoischen A, Smeekens SP, Joosten LA, Gilissen C, et al. (July 2011).
730:
537:
3118:
2978:
2958:
2937:
2856:
2795:
2739:
2693:
2617:
2522:
1713:
707:
276:
117:
3775:
935:, Advances in Experimental Medicine and Biology, vol. 941, Springer Netherlands, pp. 117–138,
2628:
3740:
1014:"A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits"
3523:
2511:
2239:
1249:
1025:
897:
738:
621:
525:
506:
341:
170:
2653:
793:
3514:
3072:
2867:
2643:
2537:
2081:
1116:"Production of IL-12 by Peyer patch-dendritic cells is critical for the resistance to food allergy"
3384:
3379:
3364:
3276:
3255:
2704:
2638:
2597:
2541:
2514:
2248:
2205:
2120:
1963:
1827:
1373:
1353:
821:
749:
655:
3245:
3113:
3020:
2999:
2750:
2719:
2714:
2658:
2577:
3291:
2724:
2552:
2547:
2897:
2882:
2846:
2816:
2562:
2112:
1731:
1597:
1345:
1306:
1265:
1217:
1194:
1137:
1092:
1053:
994:
954:
944:
913:
870:
813:
761:
600:. IL-12Rβ2 is considered to play a key role in IL-12 function, since it is found on activated
295:
227:
54:
3735:
2424:
2345:
2213:
1902:
1736:
1337:
1296:
1257:
1186:
1127:
1084:
1043:
1033:
984:
936:
905:
860:
852:
805:
633:
564:
553:
498:
336:
165:
30:
3211:
3207:
3203:
411:
345:
3527:
1951:
1637:
679:
399:
365:
194:
174:
1253:
1029:
901:
662:
in mice or a treatment of mice with IL-12 specific antibodies ameliorated the disease.
3725:
3715:
3710:
3696:
3682:
3672:
3667:
3614:
3596:
3575:
3554:
3533:
3519:
3493:
3437:
3405:
3369:
3332:
3327:
3322:
3286:
3281:
3195:
3174:
3128:
3046:
3025:
2760:
2729:
2465:
2460:
2315:
2311:
2293:
2288:
2091:
2086:
2076:
2071:
2066:
2061:
2056:
2052:
2021:
2016:
2011:
1990:
1985:
1980:
1930:
1925:
1920:
1915:
1863:
1848:
1839:
1396:
989:
972:
865:
840:
659:
609:
605:
427:
423:
1190:
1012:
Presky DH, Yang H, Minetti LJ, Chua AO, Nabavi N, Wu CY, et al. (November 1996).
3759:
3467:
3123:
2989:
2948:
2872:
2806:
2755:
2709:
2648:
2533:
2455:
2450:
2445:
2391:
2340:
2006:
1910:
1886:
1881:
1858:
1853:
1844:
1835:
1617:
1048:
1013:
545:
541:
510:
470:
439:
1357:
825:
640:
3641:
3462:
3148:
3143:
3138:
2887:
2826:
2785:
1936:
1768:
717:
651:
2480:
1261:
312:
141:
3472:
3452:
3415:
3250:
3240:
3092:
3087:
2922:
2892:
2831:
2673:
2633:
2592:
2587:
2357:
2303:
2044:
1803:
1726:
1155:
940:
683:
454:
415:
407:
395:
375:
204:
1132:
1115:
1018:
Proceedings of the
National Academy of Sciences of the United States of America
592:
IL-12 binds to the IL-12 receptor, which is a heterodimeric receptor formed by
3457:
3447:
3342:
3235:
3230:
3051:
2912:
2902:
2836:
2770:
2683:
2678:
2607:
2410:
2103:
1793:
1753:
1088:
809:
792:
Kaliński P, Hilkens CM, Snijders A, Snijdewint FG, Kapsenberg ML (July 1997).
722:
712:
560:
514:
478:
403:
319:
148:
1038:
2927:
2917:
2907:
2780:
1415:
1365:
909:
773:
568:
462:
1349:
1310:
1198:
1141:
1114:
Temblay JN, Bertelli E, Arques JL, Regoli M, Nicoletti C (September 2007).
1096:
998:
958:
874:
528:
and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of
1341:
1301:
1284:
1269:
1057:
917:
817:
678:
Interleukin 12 (IL-12) is produced by activated antigen-presenting cells (
579:
drug. However, it has not been shown to have substantial activity in the
2567:
2405:
1400:
1285:"STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis"
1214:
Primary immunodeficiency diseases : a molecular and genetic approach
695:
687:
549:
529:
494:
442:
324:
153:
3686:
3169:
1175:"Interferon-gamma and interleukin-12 pathway defects and human disease"
691:
629:
601:
300:
59:
3301:
2283:
2180:
2175:
2170:
2165:
2160:
2155:
1873:
1678:
1662:
1657:
1652:
1647:
1642:
1632:
1627:
584:
creating an anti-inflammatory effect in inflammatory bowel disease.
580:
576:
572:
490:
307:
136:
1174:
856:
3608:
3604:
3600:
3219:
3215:
3199:
2319:
2278:
2273:
2268:
2263:
2258:
2195:
2185:
2150:
2145:
2140:
2135:
2130:
2125:
1778:
1773:
1763:
1748:
1743:
1622:
1612:
1607:
1602:
1592:
1587:
1581:
1565:
1555:
1550:
1545:
1540:
1535:
1530:
1525:
1520:
1514:
1509:
1504:
1499:
1494:
1489:
1484:
1479:
753:
625:
474:
466:
446:
85:
70:
513:
mediated suppression of IFN-γ. T cells that produce IL-12 have a
2243:
2190:
1758:
1699:
1694:
1474:
1469:
1464:
1459:
1453:
1447:
1441:
1435:
1430:
757:
518:
288:
129:
2484:
1369:
933:
Regulation of
Cytokine Gene Expression in Immunity and Diseases
3676:
533:
1216:. New York: Oxford University Press. pp. 390–401.
748:
result from a mutation further downstream in the IL-12
729:
Support is lent to this idea by the observation that a
3660:
3640:
3633:
3584:
3563:
3542:
3502:
3481:
3425:
3393:
3352:
3310:
3264:
3183:
3157:
3101:
3060:
3034:
3008:
2977:
2957:
2936:
2855:
2794:
2738:
2692:
2616:
2521:
2375:
2333:
2302:
2230:
2204:
2111:
2102:
2043:
2034:
1999:
1962:
1900:
1872:
1826:
1811:
1802:
1712:
1687:
1671:
1574:
1423:
1414:
1407:
744:Defective Th1 and Th17 immune responses leading to
654:. Administration of IL-12 to people suffering from
524:IL-12 plays an important role in the activities of
371:
361:
356:
335:
330:
318:
306:
294:
282:
270:
258:
250:
242:
237:
218:
200:
190:
185:
164:
159:
147:
135:
123:
111:
99:
91:
81:
76:
69:
53:
45:
40:
23:
841:"IL-12 family cytokines: immunological playmakers"
552:. Enhanced functional response is demonstrated by
544:and the signal transduction of IL-12 in NK cells.
489:IL-12 is involved in the differentiation of naive
608:development and inhibited by those that promote
465:of p40 are formed following protein synthesis.
1235:
1233:
1120:The Journal of Allergy and Clinical Immunology
567:, which in turn increases the production of a
35:Crystal structure of human IL-12 (red helices)
2496:
1381:
620:. These are important in activating critical
8:
752:. The trait was mapped to mutations in the
604:and is stimulated by cytokines that promote
632:and NK cells. This pathway is known as the
521:, which is associated with IL-12 activity.
3637:
2503:
2489:
2481:
2108:
2040:
1823:
1808:
1420:
1411:
1388:
1374:
1366:
667:Journal of Allergy and Clinical Immunology
628:that are implicated in IL-12 signaling in
406:, neutrophils, helper T cells and human B-
353:
182:
1300:
1131:
1047:
1037:
988:
864:
540:. There also seems to be a link between
3668:Interleukin 14 (taxilin alpha, HMW-BCGF)
556:production and killing of target cells.
1173:Dorman SE, Holland SM (December 2000).
784:
690:responses and is a powerful inducer of
2966:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
1071:Wang KS, Frank DA, Ritz J (May 2000).
571:called inducible protein-10 (IP-10 or
215:
66:
20:
674:IL-12 and IL-12 receptor β1 mutations
7:
1179:Cytokine & Growth Factor Reviews
839:Vignali DA, Kuchroo VK (July 2012).
711:infection was found to have a large
1289:The New England Journal of Medicine
1156:"Food allergy molecule discovered"
971:Kashani A, Schwartz D (May 2019).
686:). It promotes the development of
14:
977:Gastroenterology & Hepatology
746:chronic mucocutaneous candidiasis
418:cytokines, which includes IL-12,
469:is composed of a bundle of four
226:
29:
3494:Interleukin 27 (interleukin 30)
716:intracellular bacteria such as
641:Reactome: Interleukin-12 family
445:encoded by two separate genes,
1330:European Journal of Immunology
398:that is naturally produced by
1:
1262:10.1126/science.280.5368.1432
1191:10.1016/s1359-6101(00)00010-1
3771:Genes on human chromosome 5
3766:Genes on human chromosome 3
2844:Antisense oligonucleotides:
941:10.1007/978-94-024-0921-5_6
503:tumor necrosis factor-alpha
232:Crystal structure of IL-12B
3792:
1133:10.1016/j.jaci.2007.04.044
2351:Colony-stimulating factor
1089:10.1182/blood.V95.10.3183
810:10.4049/jimmunol.159.1.28
665:Results published in the
505:(TNF-α) from T cells and
352:
225:
181:
28:
2386:proinflammatory cytokine
1039:10.1073/pnas.93.24.14002
703:Bacillus Calmette–Guérin
3534:Interleukin-29 (IFN-λ1)
2679:Daclizumab (dacliximab)
2664:Tucotuzumab celmoleukin
910:10.1126/science.8097338
538:cytotoxic T lymphocytes
3515:Interferon λ4 (IFN-λ4)
2608:Rilonacept (IL-1 Trap)
1517:/PARC/DCCK1/AMAC1/MIP4
708:Salmonella enteritidis
3438:Interleukin 23 (SGRF)
3119:Cintredekin besudotox
3047:Interleukin 11 (AGIF)
3026:Interleukin 10 (CSIF)
1342:10.1002/eji.200838463
1302:10.1056/NEJMoa1100102
798:Journal of Immunology
739:premature stop codons
650:IL-12 is linked with
2512:Interleukin receptor
694:production by T and
622:transcription factor
559:IL-12 also has anti-
526:natural killer cells
408:lymphoblastoid cells
24:Human Interleukin 12
2644:Denileukin diftitox
2082:Interferon type III
1254:1998Sci...280.1432A
1030:1996PNAS...9314002P
902:1993Sci...260..547H
656:autoimmune diseases
588:Signal transduction
509:cells, and reduces
507:natural killer (NK)
3216:E (interleukin 25)
750:signalling pathway
453:(p40). The active
434:Gene and structure
3753:
3752:
3749:
3748:
3718:(signals through
3699:(signals through
3685:(signals through
3675:(signals through
3299:Binding proteins:
2629:Adargileukin alfa
2478:
2477:
2371:
2370:
2329:
2328:
2226:
2225:
2222:
2221:
2030:
2029:
1708:
1707:
1223:978-0-19-514774-2
950:978-94-024-0919-2
845:Nature Immunology
624:proteins such as
457:(referred to as '
385:
384:
381:
380:
254:CLMF2, NKSF2, p40
214:
213:
210:
209:
95:CLMF1, NKSF1, p35
65:
64:
3783:
3741:Efineptakin alfa
3736:Efavaleukin alfa
3638:
2605:Decoy receptors:
2505:
2498:
2491:
2482:
2109:
2041:
1824:
1809:
1421:
1412:
1390:
1383:
1376:
1367:
1361:
1315:
1314:
1304:
1280:
1274:
1273:
1248:(5368): 1432–5.
1237:
1228:
1227:
1209:
1203:
1202:
1170:
1164:
1163:
1152:
1146:
1145:
1135:
1111:
1105:
1104:
1099:. Archived from
1068:
1062:
1061:
1051:
1041:
1009:
1003:
1002:
992:
968:
962:
961:
928:
922:
921:
885:
879:
878:
868:
836:
830:
829:
789:
634:JAK-STAT pathway
565:interferon gamma
499:interferon-gamma
354:
230:
216:
183:
67:
33:
21:
3791:
3790:
3786:
3785:
3784:
3782:
3781:
3780:
3756:
3755:
3754:
3745:
3656:
3629:
3580:
3559:
3538:
3498:
3477:
3421:
3418:(against IL-22)
3389:
3348:
3345:(against IL-20)
3306:
3260:
3179:
3153:
3097:
3056:
3030:
3004:
2973:
2953:
2932:
2851:
2790:
2734:
2688:
2612:
2517:
2509:
2479:
2474:
2440:
2419:
2377:
2367:
2325:
2298:
2218:
2200:
2098:
2026:
1995:
1958:
1896:
1868:
1819:
1817:
1815:
1798:
1704:
1683:
1667:
1570:
1403:
1394:
1364:
1336:(11): 3138–49.
1327:
1323:
1321:Further reading
1318:
1282:
1281:
1277:
1239:
1238:
1231:
1224:
1211:
1210:
1206:
1172:
1171:
1167:
1154:
1153:
1149:
1113:
1112:
1108:
1083:(10): 3183–90.
1070:
1069:
1065:
1024:(24): 14002–7.
1011:
1010:
1006:
970:
969:
965:
951:
930:
929:
925:
896:(5107): 547–9.
887:
886:
882:
857:10.1038/ni.2366
838:
837:
833:
791:
790:
786:
782:
770:
680:dendritic cells
676:
648:
590:
487:
436:
400:dendritic cells
233:
220:interleukin 12B
36:
19:
12:
11:
5:
3789:
3787:
3779:
3778:
3773:
3768:
3758:
3757:
3751:
3750:
3747:
3746:
3744:
3743:
3738:
3729:
3728:
3726:Interleukin 35
3723:
3716:Interleukin 34
3713:
3711:Interleukin 32
3708:
3697:Interleukin 26
3694:
3683:Interleukin 24
3680:
3673:Interleukin 16
3670:
3664:
3662:
3658:
3657:
3655:
3654:
3646:
3644:
3635:
3631:
3630:
3628:
3627:
3618:
3617:
3615:Interleukin 38
3612:
3597:Interleukin 36
3590:
3588:
3582:
3581:
3579:
3578:
3576:Interleukin 33
3569:
3567:
3561:
3560:
3558:
3557:
3555:Interleukin 31
3548:
3546:
3540:
3539:
3537:
3536:
3531:
3520:Interleukin 28
3517:
3508:
3506:
3500:
3499:
3497:
3496:
3487:
3485:
3479:
3478:
3476:
3475:
3470:
3465:
3460:
3455:
3450:
3441:
3440:
3431:
3429:
3423:
3422:
3420:
3419:
3409:
3408:
3406:Interleukin 22
3399:
3397:
3391:
3390:
3388:
3387:
3382:
3373:
3372:
3370:Interleukin 21
3367:
3358:
3356:
3350:
3349:
3347:
3346:
3336:
3335:
3333:Interleukin 24
3330:
3328:Interleukin 20
3325:
3323:Interleukin 19
3316:
3314:
3308:
3307:
3305:
3304:
3295:
3294:
3289:
3287:Interleukin 37
3284:
3282:Interleukin 18
3279:
3270:
3268:
3262:
3261:
3259:
3258:
3253:
3248:
3243:
3238:
3233:
3224:
3223:
3196:Interleukin 17
3189:
3187:
3181:
3180:
3178:
3177:
3175:Interleukin 15
3172:
3163:
3161:
3155:
3154:
3152:
3151:
3146:
3141:
3132:
3131:
3129:Interleukin 13
3126:
3121:
3116:
3107:
3105:
3099:
3098:
3096:
3095:
3090:
3081:
3080:
3078:Interleukin 12
3075:
3066:
3064:
3058:
3057:
3055:
3054:
3049:
3040:
3038:
3032:
3031:
3029:
3028:
3023:
3014:
3012:
3006:
3005:
3003:
3002:
2993:
2992:
2983:
2981:
2975:
2974:
2972:
2971:
2963:
2961:
2955:
2954:
2952:
2951:
2942:
2940:
2934:
2933:
2931:
2930:
2925:
2920:
2915:
2910:
2905:
2900:
2895:
2890:
2885:
2876:
2875:
2870:
2861:
2859:
2853:
2852:
2850:
2849:
2840:
2839:
2834:
2829:
2820:
2819:
2810:
2809:
2800:
2798:
2792:
2791:
2789:
2788:
2783:
2774:
2773:
2764:
2763:
2761:Interleukin 13
2758:
2753:
2744:
2742:
2736:
2735:
2733:
2732:
2730:Promegapoietin
2727:
2722:
2717:
2712:
2707:
2698:
2696:
2690:
2689:
2687:
2686:
2681:
2676:
2667:
2666:
2661:
2656:
2654:Pegaldesleukin
2651:
2646:
2641:
2636:
2631:
2622:
2620:
2614:
2613:
2611:
2610:
2601:
2600:
2595:
2590:
2581:
2580:
2575:
2570:
2565:
2556:
2555:
2550:
2545:
2527:
2525:
2519:
2518:
2510:
2508:
2507:
2500:
2493:
2485:
2476:
2475:
2473:
2472:
2471:
2470:
2469:
2468:
2463:
2458:
2453:
2448:
2438:
2434:
2433:
2432:
2427:
2417:
2408:
2402:
2401:
2400:
2399:
2394:
2381:
2379:
2373:
2372:
2369:
2368:
2366:
2365:
2360:
2355:
2354:
2353:
2348:
2337:
2335:
2331:
2330:
2327:
2326:
2324:
2323:
2308:
2306:
2300:
2299:
2297:
2296:
2291:
2286:
2281:
2276:
2271:
2266:
2261:
2256:
2251:
2246:
2236:
2234:
2232:Ig superfamily
2228:
2227:
2224:
2223:
2220:
2219:
2217:
2216:
2210:
2208:
2202:
2201:
2199:
2198:
2193:
2188:
2183:
2178:
2173:
2168:
2163:
2158:
2153:
2148:
2143:
2138:
2133:
2128:
2123:
2117:
2115:
2106:
2100:
2099:
2097:
2096:
2095:
2094:
2089:
2079:
2074:
2069:
2064:
2059:
2049:
2047:
2038:
2032:
2031:
2028:
2027:
2025:
2024:
2019:
2014:
2009:
2003:
2001:
1997:
1996:
1994:
1993:
1988:
1983:
1978:
1972:
1970:
1960:
1959:
1957:
1956:
1955:
1954:
1949:
1944:
1939:
1928:
1923:
1918:
1913:
1907:
1905:
1898:
1897:
1895:
1894:
1889:
1884:
1878:
1876:
1870:
1869:
1867:
1866:
1861:
1856:
1851:
1842:
1832:
1830:
1821:
1806:
1800:
1799:
1797:
1796:
1791:
1786:
1781:
1776:
1771:
1766:
1761:
1756:
1751:
1746:
1741:
1740:
1739:
1734:
1724:
1718:
1716:
1710:
1709:
1706:
1705:
1703:
1702:
1697:
1691:
1689:
1685:
1684:
1682:
1681:
1675:
1673:
1669:
1668:
1666:
1665:
1660:
1655:
1650:
1645:
1640:
1635:
1630:
1625:
1620:
1615:
1610:
1605:
1600:
1595:
1590:
1585:
1578:
1576:
1572:
1571:
1569:
1568:
1563:
1558:
1553:
1548:
1543:
1538:
1533:
1528:
1523:
1518:
1512:
1507:
1502:
1497:
1492:
1487:
1482:
1477:
1472:
1467:
1462:
1457:
1451:
1445:
1439:
1433:
1427:
1425:
1418:
1409:
1405:
1404:
1397:Cell signaling
1395:
1393:
1392:
1385:
1378:
1370:
1363:
1362:
1324:
1322:
1319:
1317:
1316:
1275:
1229:
1222:
1204:
1165:
1162:. 1 July 2007.
1147:
1106:
1103:on 2013-04-15.
1063:
1004:
983:(5): 255–265.
963:
949:
923:
880:
831:
783:
781:
778:
777:
776:
769:
766:
675:
672:
660:gene knock-out
647:
644:
589:
586:
486:
483:
435:
432:
388:Interleukin 12
383:
382:
379:
378:
373:
369:
368:
363:
359:
358:
350:
349:
339:
333:
332:
328:
327:
322:
316:
315:
310:
304:
303:
298:
292:
291:
286:
280:
279:
274:
268:
267:
262:
256:
255:
252:
248:
247:
244:
240:
239:
235:
234:
231:
223:
222:
212:
211:
208:
207:
202:
198:
197:
192:
188:
187:
179:
178:
168:
162:
161:
157:
156:
151:
145:
144:
139:
133:
132:
127:
121:
120:
115:
109:
108:
103:
97:
96:
93:
89:
88:
83:
79:
78:
74:
73:
63:
62:
57:
51:
50:
47:
43:
42:
38:
37:
34:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
3788:
3777:
3774:
3772:
3769:
3767:
3764:
3763:
3761:
3742:
3739:
3737:
3734:
3731:
3730:
3727:
3724:
3721:
3717:
3714:
3712:
3709:
3706:
3702:
3698:
3695:
3692:
3688:
3684:
3681:
3678:
3674:
3671:
3669:
3666:
3665:
3663:
3659:
3652:
3648:
3647:
3645:
3643:
3639:
3636:
3632:
3626:
3623:
3620:
3619:
3616:
3613:
3610:
3606:
3602:
3598:
3595:
3592:
3591:
3589:
3587:
3583:
3577:
3574:
3571:
3570:
3568:
3566:
3562:
3556:
3553:
3550:
3549:
3547:
3545:
3541:
3535:
3532:
3529:
3525:
3521:
3518:
3516:
3513:
3510:
3509:
3507:
3505:
3501:
3495:
3492:
3489:
3488:
3486:
3484:
3480:
3474:
3471:
3469:
3468:Tildrakizumab
3466:
3464:
3461:
3459:
3456:
3454:
3451:
3449:
3446:
3443:
3442:
3439:
3436:
3433:
3432:
3430:
3428:
3424:
3417:
3414:
3411:
3410:
3407:
3404:
3401:
3400:
3398:
3396:
3392:
3386:
3383:
3381:
3378:
3375:
3374:
3371:
3368:
3366:
3363:
3360:
3359:
3357:
3355:
3351:
3344:
3341:
3338:
3337:
3334:
3331:
3329:
3326:
3324:
3321:
3318:
3317:
3315:
3313:
3309:
3303:
3300:
3297:
3296:
3293:
3290:
3288:
3285:
3283:
3280:
3278:
3275:
3272:
3271:
3269:
3267:
3263:
3257:
3254:
3252:
3249:
3247:
3244:
3242:
3239:
3237:
3234:
3232:
3229:
3226:
3225:
3221:
3217:
3213:
3209:
3205:
3201:
3197:
3194:
3191:
3190:
3188:
3186:
3182:
3176:
3173:
3171:
3168:
3165:
3164:
3162:
3160:
3156:
3150:
3147:
3145:
3142:
3140:
3137:
3134:
3133:
3130:
3127:
3125:
3124:Interleukin 4
3122:
3120:
3117:
3115:
3112:
3109:
3108:
3106:
3104:
3100:
3094:
3091:
3089:
3086:
3083:
3082:
3079:
3076:
3074:
3073:Edodekin alfa
3071:
3068:
3067:
3065:
3063:
3059:
3053:
3050:
3048:
3045:
3042:
3041:
3039:
3037:
3033:
3027:
3024:
3022:
3019:
3016:
3015:
3013:
3011:
3007:
3001:
2998:
2995:
2994:
2991:
2990:Interleukin 9
2988:
2985:
2984:
2982:
2980:
2976:
2969:
2965:
2964:
2962:
2960:
2956:
2950:
2949:Interleukin 7
2947:
2944:
2943:
2941:
2939:
2935:
2929:
2926:
2924:
2921:
2919:
2916:
2914:
2911:
2909:
2906:
2904:
2901:
2899:
2896:
2894:
2891:
2889:
2886:
2884:
2881:
2878:
2877:
2874:
2873:Interleukin 6
2871:
2869:
2868:Atexakin alfa
2866:
2863:
2862:
2860:
2858:
2854:
2848:
2845:
2842:
2841:
2838:
2835:
2833:
2830:
2828:
2825:
2822:
2821:
2818:
2815:
2812:
2811:
2808:
2807:Interleukin 5
2805:
2802:
2801:
2799:
2797:
2793:
2787:
2784:
2782:
2779:
2776:
2775:
2772:
2769:
2766:
2765:
2762:
2759:
2757:
2756:Interleukin 4
2754:
2752:
2749:
2746:
2745:
2743:
2741:
2737:
2731:
2728:
2726:
2723:
2721:
2718:
2716:
2713:
2711:
2710:Interleukin 3
2708:
2706:
2703:
2700:
2699:
2697:
2695:
2691:
2685:
2682:
2680:
2677:
2675:
2672:
2669:
2668:
2665:
2662:
2660:
2657:
2655:
2652:
2650:
2649:Interleukin 2
2647:
2645:
2642:
2640:
2637:
2635:
2632:
2630:
2627:
2624:
2623:
2621:
2619:
2615:
2609:
2606:
2603:
2602:
2599:
2596:
2594:
2591:
2589:
2586:
2583:
2582:
2579:
2576:
2574:
2571:
2569:
2566:
2564:
2561:
2558:
2557:
2554:
2551:
2549:
2546:
2543:
2539:
2535:
2534:Interleukin 1
2532:
2529:
2528:
2526:
2524:
2520:
2516:
2513:
2506:
2501:
2499:
2494:
2492:
2487:
2486:
2483:
2467:
2464:
2462:
2459:
2457:
2454:
2452:
2449:
2447:
2444:
2443:
2442:
2435:
2431:
2428:
2426:
2423:
2422:
2421:
2414:
2413:
2412:
2409:
2407:
2404:
2403:
2398:
2395:
2393:
2390:
2389:
2388:
2387:
2383:
2382:
2380:
2374:
2364:
2361:
2359:
2356:
2352:
2349:
2347:
2344:
2343:
2342:
2341:Hematopoietic
2339:
2338:
2336:
2332:
2321:
2317:
2313:
2310:
2309:
2307:
2305:
2301:
2295:
2292:
2290:
2287:
2285:
2282:
2280:
2277:
2275:
2272:
2270:
2267:
2265:
2262:
2260:
2257:
2255:
2252:
2250:
2247:
2245:
2241:
2238:
2237:
2235:
2233:
2229:
2215:
2212:
2211:
2209:
2207:
2203:
2197:
2194:
2192:
2189:
2187:
2184:
2182:
2179:
2177:
2174:
2172:
2169:
2167:
2164:
2162:
2159:
2157:
2154:
2152:
2149:
2147:
2144:
2142:
2139:
2137:
2134:
2132:
2129:
2127:
2124:
2122:
2119:
2118:
2116:
2114:
2110:
2107:
2105:
2101:
2093:
2090:
2088:
2085:
2084:
2083:
2080:
2078:
2075:
2073:
2070:
2068:
2065:
2063:
2060:
2058:
2054:
2051:
2050:
2048:
2046:
2042:
2039:
2037:
2033:
2023:
2020:
2018:
2015:
2013:
2010:
2008:
2005:
2004:
2002:
1998:
1992:
1989:
1987:
1984:
1982:
1979:
1977:
1974:
1973:
1971:
1969:
1965:
1961:
1953:
1950:
1948:
1945:
1943:
1940:
1938:
1934:
1933:
1932:
1929:
1927:
1924:
1922:
1919:
1917:
1914:
1912:
1909:
1908:
1906:
1904:
1899:
1893:
1890:
1888:
1885:
1883:
1880:
1879:
1877:
1875:
1871:
1865:
1862:
1860:
1857:
1855:
1852:
1850:
1846:
1843:
1841:
1837:
1834:
1833:
1831:
1829:
1825:
1822:
1814:
1810:
1807:
1805:
1801:
1795:
1792:
1790:
1787:
1785:
1782:
1780:
1777:
1775:
1772:
1770:
1767:
1765:
1762:
1760:
1757:
1755:
1752:
1750:
1749:TNFSF5/CD40LG
1747:
1745:
1742:
1738:
1735:
1733:
1730:
1729:
1728:
1725:
1723:
1720:
1719:
1717:
1715:
1711:
1701:
1698:
1696:
1693:
1692:
1690:
1686:
1680:
1677:
1676:
1674:
1670:
1664:
1661:
1659:
1656:
1654:
1651:
1649:
1646:
1644:
1641:
1639:
1636:
1634:
1631:
1629:
1626:
1624:
1621:
1619:
1616:
1614:
1611:
1609:
1606:
1604:
1601:
1599:
1596:
1594:
1591:
1589:
1586:
1583:
1580:
1579:
1577:
1573:
1567:
1564:
1562:
1559:
1557:
1554:
1552:
1549:
1547:
1544:
1542:
1539:
1537:
1534:
1532:
1529:
1527:
1524:
1522:
1519:
1516:
1513:
1511:
1508:
1506:
1503:
1501:
1498:
1496:
1493:
1491:
1488:
1486:
1483:
1481:
1478:
1476:
1473:
1471:
1468:
1466:
1463:
1461:
1458:
1455:
1452:
1449:
1446:
1443:
1440:
1437:
1434:
1432:
1429:
1428:
1426:
1422:
1419:
1417:
1413:
1410:
1406:
1402:
1398:
1391:
1386:
1384:
1379:
1377:
1372:
1371:
1368:
1359:
1355:
1351:
1347:
1343:
1339:
1335:
1331:
1326:
1325:
1320:
1312:
1308:
1303:
1298:
1294:
1290:
1286:
1279:
1276:
1271:
1267:
1263:
1259:
1255:
1251:
1247:
1243:
1236:
1234:
1230:
1225:
1219:
1215:
1208:
1205:
1200:
1196:
1192:
1188:
1185:(4): 321–33.
1184:
1180:
1176:
1169:
1166:
1161:
1157:
1151:
1148:
1143:
1139:
1134:
1129:
1126:(3): 659–65.
1125:
1121:
1117:
1110:
1107:
1102:
1098:
1094:
1090:
1086:
1082:
1078:
1074:
1067:
1064:
1059:
1055:
1050:
1045:
1040:
1035:
1031:
1027:
1023:
1019:
1015:
1008:
1005:
1000:
996:
991:
986:
982:
978:
974:
967:
964:
960:
956:
952:
946:
942:
938:
934:
927:
924:
919:
915:
911:
907:
903:
899:
895:
891:
884:
881:
876:
872:
867:
862:
858:
854:
850:
846:
842:
835:
832:
827:
823:
819:
815:
811:
807:
803:
799:
795:
788:
785:
779:
775:
772:
771:
767:
765:
763:
759:
755:
751:
747:
742:
740:
736:
732:
727:
725:
724:
719:
714:
710:
709:
704:
701:A child with
699:
697:
693:
689:
685:
681:
673:
671:
668:
663:
661:
657:
653:
645:
643:
642:
637:
635:
631:
627:
623:
619:
615:
611:
607:
603:
599:
595:
587:
585:
582:
578:
574:
570:
566:
562:
557:
555:
551:
547:
543:
539:
535:
531:
527:
522:
520:
516:
512:
508:
504:
500:
496:
492:
484:
482:
480:
476:
472:
471:alpha helices
468:
464:
460:
456:
452:
448:
444:
441:
440:heterodimeric
433:
431:
429:
425:
421:
417:
416:heterodimeric
413:
409:
405:
401:
397:
393:
389:
377:
374:
370:
367:
364:
360:
355:
351:
348:
347:
343:
340:
338:
334:
329:
326:
323:
321:
317:
314:
311:
309:
305:
302:
299:
297:
293:
290:
287:
285:
281:
278:
275:
273:
269:
266:
263:
261:
257:
253:
249:
245:
241:
236:
229:
224:
221:
217:
206:
203:
199:
196:
193:
189:
184:
180:
177:
176:
172:
169:
167:
163:
158:
155:
152:
150:
146:
143:
140:
138:
134:
131:
128:
126:
122:
119:
116:
114:
110:
107:
104:
102:
98:
94:
90:
87:
84:
80:
75:
72:
68:
61:
58:
56:
52:
48:
44:
39:
32:
27:
22:
16:
3776:Interleukins
3732:
3720:M-CSFR/CSF1R
3707:heterodimer)
3693:heterodimer)
3622:Antagonists:
3621:
3593:
3572:
3551:
3511:
3490:
3463:Risankizumab
3444:
3434:
3412:
3402:
3385:NNC0114-0006
3380:NNC0114-0005
3376:
3361:
3339:
3319:
3298:
3273:
3227:
3192:
3166:
3149:Tralokinumab
3144:Lebrikizumab
3139:Anrukinzumab
3135:
3110:
3084:
3077:
3069:
3043:
3017:
2996:
2986:
2945:
2888:Clazakizumab
2879:
2864:
2843:
2827:Benralizumab
2823:
2814:Antagonists:
2813:
2803:
2786:Pascolizumab
2777:
2768:Antagonists:
2767:
2747:
2701:
2670:
2625:
2604:
2584:
2560:Antagonists:
2559:
2530:
2436:
2415:
2384:
2376:By function/
2087:IL28/IFNL2+3
1975:
1333:
1329:
1295:(1): 54–61.
1292:
1288:
1278:
1245:
1241:
1213:
1207:
1182:
1178:
1168:
1159:
1150:
1123:
1119:
1109:
1101:the original
1080:
1076:
1066:
1021:
1017:
1007:
980:
976:
966:
932:
926:
893:
889:
883:
851:(8): 722–8.
848:
844:
834:
804:(1): 28–35.
801:
797:
787:
743:
734:
728:
721:
718:mycobacteria
706:
700:
677:
666:
664:
652:autoimmunity
649:
646:Autoimmunity
638:
617:
613:
591:
558:
523:
501:(IFN-γ) and
488:
458:
437:
391:
387:
386:
344:
251:Alt. symbols
173:
92:Alt. symbols
15:
3473:Ustekinumab
3453:Briakinumab
3445:Antibodies:
3416:Fezakinumab
3413:Antibodies:
3377:Antibodies:
3365:Denenicokin
3340:Antibodies:
3277:Iboctadekin
3256:Vunakizumab
3251:Secukinumab
3241:Perakizumab
3228:Antibodies:
3136:Antibodies:
3093:Ustekinumab
3088:Briakinumab
3085:Antibodies:
2997:Antibodies:
2923:Tocilizumab
2893:Elsilimomab
2880:Antibodies:
2832:Mepolizumab
2824:Antibodies:
2778:Antibodies:
2705:Daniplestim
2674:Basiliximab
2671:Antibodies:
2639:Celmoleukin
2634:Aldesleukin
2598:Lutikizumab
2593:Gevokizumab
2588:Canakinumab
2585:Antibodies:
2304:IL17 family
2045:IL10 family
1964:IL12 family
1816:(grouped by
1804:Interleukin
1727:Lymphotoxin
684:macrophages
455:heterodimer
404:macrophages
396:interleukin
366:Swiss-model
238:Identifiers
195:Swiss-model
77:Identifiers
41:Identifiers
18:Interleukin
3760:Categories
3528:B (IFN-λ3)
3524:A (IFN-λ2)
3458:Guselkumab
3448:Brazikumab
3343:Fletikumab
3246:Remtolumab
3236:Ixekizumab
3231:Brodalumab
3114:Binetrakin
3052:Oprelvekin
3021:Ilodecakin
3000:Enokizumab
2913:Siltuximab
2903:Olokizumab
2837:Reslizumab
2771:Pitrakinra
2751:Binetrakin
2720:Milodistim
2715:Leridistim
2684:Inolimomab
2659:Teceleukin
2578:Isunakinra
2515:modulators
2411:Lymphokine
2249:IL1B/IL1F2
2244:IL1A/IL1F1
2240:IL1 family
2104:Interferon
2092:IL29/IFNL1
780:References
764:activity.
735:Salmonella
723:Salmonella
713:homozygous
561:angiogenic
515:coreceptor
479:beta sheet
477:has three
461:'), and a
449:(p35) and
438:IL12 is a
362:Structures
357:Search for
346:q31.1-33.1
331:Other data
191:Structures
186:Search for
160:Other data
3733:Unsorted:
3594:Agonists:
3573:Agonists:
3552:Agonists:
3512:Agonists:
3491:Agonists:
3435:Agonists:
3403:Agonists:
3362:Agonists:
3320:Agonists:
3292:Tadekinig
3274:Agonists:
3193:Agonists:
3167:Agonists:
3111:Agonists:
3070:Agonists:
3044:Agonists:
3018:Agonists:
2987:Agonists:
2946:Agonists:
2928:Levilimab
2918:Sirukumab
2908:Sarilumab
2865:Agonists:
2804:Agonists:
2781:Dupilumab
2748:Agonists:
2725:Muplestim
2702:Agonists:
2626:Agonists:
2553:Pifonakin
2548:Mobenakin
2531:Agonists:
2289:33/IL1F11
2254:1Ra/IL1F3
1901:IL6 like/
1618:CXCL8/IL8
1416:Chemokine
1408:By family
1401:cytokines
774:CNTO 1275
610:Th2 cells
606:Th1 cells
569:chemokine
495:Th1 cells
485:Functions
481:domains.
463:homodimer
313:NM_002187
260:NCBI gene
175:p12-q13.2
142:NM_000882
101:NCBI gene
49:IL12, p70
3687:IL-22Rα1
3653:instead.
2970:instead.
2898:mAb 1339
2883:ARGX-109
2847:TPI ASM8
2817:YM-90709
2568:Anakinra
2563:AF-12198
2406:Monokine
1935:+non IL
1820:subunit)
1818:receptor
1789:TNFSF13B
1737:TNFC/LTB
1732:TNFB/LTA
1358:25717745
1350:18924208
1311:21714643
1199:10959079
1160:BBC News
1142:17599398
1097:10807786
999:31360139
959:27734411
875:22814351
826:10617490
768:See also
731:receptor
696:NK cells
670:humans.
598:IL-12Rβ2
594:IL-12Rβ1
550:NK cells
530:NK cells
443:cytokine
394:) is an
376:InterPro
205:InterPro
3705:IL-10Rβ
3701:IL-20Rα
3691:IL-20Rβ
3625:IL-36RA
3170:ALT-803
2294:18/IL1G
2036:Type II
1968:IL12RB1
1874:β chain
1828:γ chain
1784:TNFSF13
1779:TNFSF11
1774:TNFSF10
1456:/RANTES
1270:9603732
1250:Bibcode
1242:Science
1058:8943050
1026:Bibcode
990:6589846
918:8097338
898:Bibcode
890:Science
866:4158817
818:9200435
630:T cells
602:T cells
491:T cells
372:Domains
320:UniProt
201:Domains
149:UniProt
3661:Others
3634:Others
3586:IL1RL2
3565:IL1RL1
3302:IL18BP
2573:IL-1RA
2284:IL1F10
2181:IFNA21
2176:IFNA17
2171:IFNA16
2166:IFNA14
2161:IFNA13
2156:IFNA10
1813:Type I
1769:TNFSF9
1764:TNFSF8
1759:TNFSF7
1754:TNFSF6
1744:TNFSF4
1679:CX3CL1
1663:CXCL17
1658:CXCL16
1653:CXCL15
1648:CXCL14
1643:CXCL13
1638:CXCL12
1633:CXCL11
1628:CXCL10
1450:/MIP1β
1444:/MIP1α
1356:
1348:
1309:
1268:
1220:
1197:
1140:
1095:
1056:
1046:
997:
987:
957:
947:
916:
873:
863:
824:
816:
581:tumors
577:cancer
573:CXCL10
451:IL-12B
447:IL-12A
342:Chr. 5
325:P29460
308:RefSeq
289:161561
243:Symbol
171:Chr. 3
154:P29459
137:RefSeq
130:161560
82:Symbol
46:Symbol
3544:IL-31
3504:IL-28
3483:IL-27
3427:IL-23
3395:IL-22
3354:IL-21
3312:IL-20
3266:IL-18
3185:IL-17
3159:IL-15
3103:IL-13
3062:IL-12
3036:IL-11
3010:IL-10
2346:KITLG
2334:Other
2320:IL17A
2279:IL1F9
2274:IL1F8
2269:IL1F7
2264:IL1F6
2259:IL1F5
2196:IFNW1
2186:IFNB1
2151:IFNA8
2146:IFNA7
2141:IFNA6
2136:IFNA5
2131:IFNA4
2126:IFNA2
2121:IFNA1
2000:Other
1903:gp130
1892:GMCSF
1672:CX3CL
1623:CXCL9
1613:CXCL7
1608:CXCL6
1603:CXCL5
1598:CXCL4
1593:CXCL3
1588:CXCL2
1582:CXCL1
1566:CCL28
1561:CCL27
1556:CCL26
1551:CCL25
1546:CCL24
1541:CCL23
1536:CCL22
1531:CCL21
1526:CCL20
1521:CCL19
1515:CCL18
1510:CCL17
1505:CCL16
1500:CCL15
1495:CCL14
1490:CCL13
1485:CCL12
1480:CCL11
1438:/MCP1
1354:S2CID
1077:Blood
1049:19484
822:S2CID
754:STAT1
626:STAT4
554:IFN-γ
493:into
475:IL12B
467:IL12A
428:IL-35
424:IL-27
420:IL-23
412:NC-37
392:IL-12
337:Locus
246:IL12B
166:Locus
86:IL12A
71:IL12A
3651:here
3649:See
2979:IL-9
2968:here
2959:IL-8
2938:IL-7
2857:IL-6
2796:IL-5
2740:IL-4
2694:IL-3
2618:IL-2
2523:IL-1
2466:IL13
2461:IL10
2430:TNFβ
2425:IFNγ
2397:TNFA
2378:cell
2358:SPP1
2316:IL25
2312:IL17
2214:IFNG
2191:IFNK
2077:IL26
2072:IL24
2067:IL20
2062:IL19
2057:IL22
2053:IL10
2022:IL34
2017:IL32
2012:IL16
2007:IL14
1991:IL35
1986:IL27
1981:IL23
1976:IL12
1952:CTF1
1947:CNTF
1931:IL31
1926:IL30
1921:IL27
1916:IL11
1864:IL21
1849:IL13
1840:IL15
1722:TNFA
1700:XCL2
1695:XCL1
1575:CXCL
1475:CCL9
1470:CCL8
1465:CCL7
1460:CCL6
1454:CCL5
1448:CCL4
1442:CCL3
1436:CCL2
1431:CCL1
1346:PMID
1307:PMID
1266:PMID
1218:ISBN
1195:PMID
1138:PMID
1093:PMID
1054:PMID
995:PMID
955:PMID
945:ISBN
914:PMID
871:PMID
814:PMID
762:Tyk2
760:and
758:Jak2
720:and
705:and
692:IFNγ
618:Jak2
616:and
614:Tyk2
596:and
546:IL-2
542:IL-2
532:and
519:CD30
511:IL-4
426:and
301:1F42
284:OMIM
277:5970
272:HGNC
265:3593
125:OMIM
118:5969
113:HGNC
106:3592
60:1F45
3677:CD4
3642:JAK
2456:IL6
2451:IL5
2446:IL4
2392:IL1
2363:MIF
1942:LIF
1937:OSM
1911:IL6
1887:IL5
1882:IL3
1859:IL9
1854:IL7
1845:IL4
1836:IL2
1794:EDA
1714:TNF
1688:XCL
1584:/KC
1424:CCL
1338:doi
1297:doi
1293:365
1258:doi
1246:280
1187:doi
1128:doi
1124:120
1085:doi
1044:PMC
1034:doi
985:PMC
937:doi
906:doi
894:260
861:PMC
853:doi
806:doi
802:159
688:Th1
534:CD8
473:.
459:p70
296:PDB
55:PDB
3762::
3607:,
3603:,
3526:,
3218:,
3214:,
3210:,
3206:,
3202:,
2540:,
2242::
2206:II
1399::
1352:.
1344:.
1334:38
1332:.
1305:.
1291:.
1287:.
1264:.
1256:.
1244:.
1232:^
1193:.
1183:11
1181:.
1177:.
1158:.
1136:.
1122:.
1118:.
1091:.
1081:95
1079:.
1075:.
1052:.
1042:.
1032:.
1022:93
1020:.
1016:.
993:.
981:15
979:.
975:.
953:,
943:,
912:.
904:.
892:.
869:.
859:.
849:13
847:.
843:.
820:.
812:.
800:.
796:.
726:.
698:.
682:,
636:.
536:+
517:,
422:,
402:,
3722:)
3703:/
3689:/
3679:)
3611:)
3609:γ
3605:β
3601:α
3599:(
3530:)
3522:(
3222:)
3220:F
3212:D
3208:C
3204:B
3200:A
3198:(
2544:)
2542:β
2538:α
2536:(
2504:e
2497:t
2490:v
2441:2
2439:h
2437:T
2420:1
2418:h
2416:T
2322:)
2318:(
2314:/
2113:I
2055:/
1966:/
1847:/
1838:/
1389:e
1382:t
1375:v
1360:.
1340::
1313:.
1299::
1272:.
1260::
1252::
1226:.
1201:.
1189::
1144:.
1130::
1087::
1060:.
1036::
1028::
1001:.
939::
920:.
908::
900::
877:.
855::
828:.
808::
410:(
390:(
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