331:
308:
205:
230:
2340:
596:
589:
582:
2355:
2325:
337:
236:
42:
1270:), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
68:
1870:
Hope S, Melle I, Aukrust P, Steen NE, Birkenaes AB, Lorentzen S, et al. (November 2009). "Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von
Willebrand factor".
1261:
family. IL-1RA is secreted by various types of cells including immune cells, epithelial cells, and adipocytes, and is a natural inhibitor of the pro-inflammatory effect of IL1β. This protein inhibits the activities of interleukin 1, alpha
1334:. The cytoplasmic isoform can protect epithelial cells from environmental factors and compete with IL1A in binding with receptors preventing activation. Then, the secreted isoform regulates IL1B in tumor microenvironments by inhibiting
1835:
Zanardini R, Bocchio-Chiavetto L, Scassellati C, Bonvicini C, Tura GB, Rossi G, et al. (2003). "Association between IL-1beta -511C/T and IL-1RA (86bp)n repeats polymorphisms and schizophrenia".
1445:
Steinkasserer A, Spurr NK, Cox S, Jeggo P, Sim RB (July 1992). "The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci".
2076:"Tumour necrosis factor alpha, interleukin 1 beta and interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors"
1480:
Patterson D, Jones C, Hart I, Bleskan J, Berger R, Geyer D, et al. (January 1993). "The human interleukin-1 receptor antagonist (IL1RN) gene is located in the chromosome 2q14 region".
3510:
1241:
IL-1RA was initially called the IL-1 inhibitor and was discovered separately in 1984 by two independent laboratories. IL-1RA is an agent that binds non-productively to the cell surface
1641:"Osteoporotic fractures are associated with an 86-base pair repeat polymorphism in the interleukin-1--receptor antagonist gene but not with polymorphisms in the interleukin-1beta gene"
1294:
2339:
1792:
Kim SJ, Lee HJ, Koo HG, Kim JW, Song JY, Kim MK, et al. (September 2004). "Impact of IL-1 receptor antagonist gene polymorphism on schizophrenia and bipolar disorder".
344:
243:
2899:
1323:
disease in which IL-1 plays a key role. Anakinra differs from native human IL-1RA in that it has the addition of a single methionine residue at its amino terminus
3503:
1297:(DIRA). Variants of the IL1RN gene is also associated with risk of schizophrenia. Elevated levels of IL-1RA has been found in serum of schizophrenia patients.
2354:
904:
166:
885:
3496:
2324:
2975:
4708:
3975:
3370:
4712:
4698:
4658:
2304:
1427:
1409:
4773:
4727:
1350:
secondary to joint and soft-tissue injury. IL-1RA obstructs the IL1B inflammatory cascade rather than helping to restore damaged tissue.
2395:
1304:(mRNA) of IL-1RA can be used. The IL-1RA mRNA reduces pain and joint inflammation by blocking inflammatory cascade signals that lead to
1160:
330:
4632:
1918:"Anti-Inflammatory Therapy for Temporomandibular Joint Osteoarthritis Using mRNA Medicine Encoding Interleukin-1 Receptor Antagonist"
3580:
3261:
2207:
Sehouli J, Mustea A, Könsgen D, Katsares I, Lichtenegger W (2003). "Polymorphism of IL-1 receptor antagonist gene: role in cancer".
1167:
307:
2228:
Kamangar F, Cheng C, Abnet CC, Rabkin CS (October 2006). "Interleukin-1B polymorphisms and gastric cancer risk--a meta-analysis".
1621:
2791:
1396:
1375:
1392:
229:
204:
65:
4593:
4572:
2568:
1371:
1347:
146:
3404:
2954:
2729:
2272:
343:
242:
3437:
3239:
2949:
336:
235:
3358:
3043:
2297:
1290:
3393:
2820:
2796:
2276:
949:
154:
1743:
Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, et al. (June 2009).
4551:
4511:
4490:
4434:
4402:
4361:
4319:
4273:
4192:
4166:
4110:
4069:
4043:
4017:
3671:
2388:
1331:
930:
4126:
1278:
A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and
3986:
3966:
3945:
3864:
3803:
3747:
3701:
3625:
3530:
2721:
1242:
2128:
Arend WP, Malyak M, Guthridge CJ, Gabay C (1998). "Interleukin-1 receptor antagonist: role in biology".
1998:
3636:
137:, DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4, interleukin 1 receptor antagonist
4748:
4531:
3519:
3247:
2290:
2028:
1701:
1577:
1316:
218:
3661:
2074:
Smith EJ, Beaumont RE, McClellan A, Sze C, Palomino Lago E, Hazelgrove L, et al. (March 2023).
133:
4522:
4080:
3875:
3651:
3545:
3089:
1139:
1135:
1114:
1092:
1064:
1060:
1039:
1029:
4392:
4387:
4778:
4372:
4284:
4263:
3712:
3646:
3605:
3549:
3522:
3256:
3213:
3128:
2971:
2835:
2381:
2253:
1817:
1725:
1670:
1603:
1546:
178:
17:
4253:
4121:
4028:
4007:
3758:
3727:
3722:
3666:
3585:
2017:"Interleukin-1 receptor antagonist: a promising cytokine against human squamous cell carcinomas"
1143:
1104:
1100:
1096:
1088:
1068:
1025:
1021:
1017:
1013:
4299:
3732:
3560:
3555:
3905:
3890:
3854:
3824:
3570:
3120:
2739:
2605:
2245:
2216:
2195:
2166:
2145:
2105:
2056:
1980:
1949:
1898:
1852:
1809:
1774:
1717:
1662:
1595:
1538:
1497:
1462:
595:
588:
581:
126:
58:
4743:
3432:
3353:
3221:
2910:
2744:
2237:
2187:
2137:
2095:
2087:
2046:
2036:
1972:
1939:
1929:
1888:
1880:
1844:
1801:
1764:
1756:
1709:
1688:
El-Omar EM, Carrington M, Chow WH, McColl KE, Bream JH, Young HA, et al. (March 2000).
1652:
1585:
1528:
1489:
1454:
423:
354:
298:
253:
4219:
4215:
4211:
1689:
174:
4535:
2959:
2645:
2348:: COMPLEX OF THE INTERLEUKIN-1 RECEPTOR WITH THE INTERLEUKIN-1 RECEPTOR ANTAGONIST (IL1RA)
1327:
398:
2051:
2032:
2016:
1916:
Deng J, Fukushima Y, Nozaki K, Nakanishi H, Yada E, Terai Y, et al. (August 2022).
1705:
1581:
1338:
of IL1B and proliferation of tumor cells, thus preventing the movement of tumor cells.
4733:
4723:
4718:
4704:
4690:
4680:
4675:
4622:
4604:
4583:
4562:
4541:
4527:
4501:
4445:
4413:
4377:
4340:
4335:
4330:
4294:
4289:
4203:
4182:
4136:
4085:
4054:
4033:
3768:
3737:
3473:
3468:
3323:
3319:
3301:
3296:
3099:
3094:
3084:
3079:
3074:
3069:
3064:
3060:
3029:
3024:
3019:
2998:
2993:
2988:
2983:
2938:
2933:
2928:
2923:
2871:
2856:
2847:
2404:
2100:
2075:
1944:
1917:
1769:
1744:
1628:. National Center for Biotechnology Information (NCBI), U.S. National Library Medicine.
1305:
1279:
2191:
1848:
1745:"An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist"
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
718:
713:
708:
703:
698:
693:
688:
672:
667:
662:
657:
652:
647:
642:
637:
4767:
4475:
4131:
3997:
3956:
3880:
3814:
3763:
3717:
3656:
3541:
3463:
3458:
3453:
3399:
3348:
3014:
2918:
2894:
2889:
2866:
2861:
2852:
2843:
2625:
1884:
1805:
1458:
1311:
A recombinant, slightly modified version of interleukin 1 receptor antagonist called
1301:
1246:
624:
2141:
1821:
1674:
1607:
1550:
4649:
4470:
4156:
4151:
4146:
3895:
3834:
3793:
2944:
2776:
2257:
1976:
1729:
416:
195:
3488:
2241:
2041:
1934:
1590:
1565:
158:
182:
4480:
4460:
4423:
4258:
4248:
4100:
4095:
3930:
3900:
3839:
3681:
3641:
3600:
3595:
3365:
3311:
3052:
2811:
2734:
2159:
Monaldi
Archives for Chest Disease = Archivio Monaldi per le Malattie del Torace
2157:
Adcock IM, Ito K (June 2000). "Molecular mechanisms of corticosteroid actions".
1533:
1516:
1432:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1414:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2091:
1657:
1640:
499:
4465:
4455:
4350:
4243:
4238:
4059:
3920:
3910:
3844:
3778:
3691:
3686:
3615:
3418:
3111:
2801:
2761:
1690:"Interleukin-1 polymorphisms associated with increased risk of gastric cancer"
1335:
1320:
315:
212:
162:
3935:
3925:
3915:
3788:
2423:
2373:
849:
559:
437:
382:
369:
281:
268:
170:
2249:
2220:
2199:
2170:
2109:
2060:
1984:
1953:
1902:
1856:
1813:
1778:
1721:
1666:
1599:
1493:
2149:
1760:
1542:
1501:
1466:
1207:
1202:
41:
3575:
3413:
2408:
1967:
Mertens M, Singh JA (January 2009). "Anakinra for rheumatoid arthritis".
1639:
Langdahl BL, Løkke E, Carstens M, Stenkjaer LL, Eriksen EF (March 2000).
1312:
1286:
1258:
1191:
994:
975:
4694:
4177:
2363:: SOLUTION STRUCTURE OF HUMAN INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN
1893:
1566:"IL-1 receptor antagonist in metabolic diseases: Dr Jekyll or Mr Hyde?"
1228:
961:
916:
103:
99:
95:
91:
87:
4309:
3291:
3188:
3183:
3178:
3173:
3168:
3163:
2881:
2686:
2670:
2665:
2660:
2655:
2650:
2640:
2635:
1713:
1249:
family (IL-1), preventing IL-1's from sending a signal to that cell.
1175:
871:
2178:
Arend WP (2003). "The balance between IL-1 and IL-1Ra in disease".
1300:
In treatment of temporomandibular joint osteoarthritis (TMJOA) the
4616:
4612:
4608:
4227:
4223:
4207:
3327:
3286:
3281:
3276:
3271:
3266:
3203:
3193:
3158:
3153:
3148:
3143:
3138:
3133:
2786:
2781:
2771:
2756:
2751:
2630:
2620:
2615:
2610:
2600:
2595:
2589:
2573:
2563:
2558:
2553:
2548:
2543:
2538:
2533:
2528:
2522:
2517:
2512:
2507:
2502:
2497:
2492:
2487:
834:
830:
3251:
3198:
2766:
2707:
2702:
2482:
2477:
2472:
2467:
2461:
2455:
2449:
2443:
2438:
1267:
1263:
1235:
150:
3492:
2377:
2286:
735:
negative regulation of interleukin-1-mediated signaling pathway
604:
4684:
2282:
2333:: CRYSTAL STRUCTURE OF THE INTERLEUKIN-1 RECEPTOR ANTAGONIST
1346:
Interleukin 1 receptor antagonist is used in horses for the
805:
positive regulation of I-kappaB kinase/NF-kappaB signaling
765:
negative regulation of cytokine-mediated signaling pathway
406:
760:
negative regulation of heterotypic cell-cell adhesion
571:
1999:"Kineret (anakinra) injection, for subcutaneous use"
1564:
Perrier S, Darakhshan F, Hajduch E (November 2006).
4668:
4648:
4641:
4592:
4571:
4550:
4510:
4489:
4433:
4401:
4360:
4318:
4272:
4191:
4165:
4109:
4068:
4042:
4016:
3985:
3965:
3944:
3863:
3802:
3746:
3700:
3624:
3529:
3383:
3341:
3310:
3238:
3212:
3119:
3110:
3051:
3042:
3007:
2970:
2908:
2880:
2834:
2819:
2810:
2720:
2695:
2679:
2582:
2431:
2422:
2415:
1295:
deficiency of the interleukin-1–receptor antagonist
1128:
1087:
1053:
1012:
1388:
1386:
1384:
1367:
1365:
1363:
658:interleukin-1 type II receptor antagonist activity
1517:"The interleukin-1 family: 10 years of discovery"
638:interleukin-1 type I receptor antagonist activity
353:
252:
2230:Cancer Epidemiology, Biomarkers & Prevention
800:positive regulation of interleukin-6 production
1393:GRCm38: Ensembl release 89: ENSMUSG00000026981
3504:
2389:
2298:
8:
1969:The Cochrane Database of Systematic Reviews
1372:GRCh38: Ensembl release 89: ENSG00000136689
4645:
3511:
3497:
3489:
3116:
3048:
2831:
2816:
2428:
2419:
2396:
2382:
2374:
2305:
2291:
2283:
2015:Ding Y, Yi J, Wang J, Sun Z (April 2023).
1084:
1009:
845:
673:interleukin-1 receptor antagonist activity
620:
394:
293:
190:
76:
2275:at the U.S. National Library of Medicine
2273:Interleukin+1+Receptor+Antagonist+Protein
2099:
2050:
2040:
1943:
1933:
1892:
1768:
1656:
1622:"IL1RN interleukin 1 receptor antagonist"
1589:
1532:
785:regulation of signaling receptor activity
4676:Interleukin 14 (taxilin alpha, HMW-BCGF)
1257:IL-1RA is a member of the interleukin 1
815:interleukin-1-mediated signaling pathway
2320:
1359:
820:cellular response to lipopolysaccharide
643:interleukin-1, type II receptor binding
3974:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
1330:of IL-1RA can suppress tumors such as
1245:(IL-1R), the same receptor that binds
653:interleukin-1, type I receptor binding
31:
358:
319:
314:
257:
216:
211:
7:
2180:Cytokine & Growth Factor Reviews
1645:Journal of Bone and Mineral Research
1289:in the IL1RN gene results in a rare
1749:The New England Journal of Medicine
790:cytokine-mediated signaling pathway
1125:
1050:
985:
966:
940:
921:
895:
876:
810:positive regulation of JNK cascade
704:intracellular anatomical structure
576:
494:
432:
411:
25:
1231:that in humans is encoded by the
1221:interleukin-1 receptor antagonist
27:Protein and coding gene in humans
18:Interleukin 1 receptor antagonist
2353:
2338:
2323:
1885:10.1111/j.1399-5618.2009.00757.x
1806:10.1097/00041444-200409000-00009
594:
587:
580:
526:lumbar subsegment of spinal cord
342:
335:
329:
306:
241:
234:
228:
203:
40:
4502:Interleukin 27 (interleukin 30)
2142:10.1146/annurev.immunol.16.1.27
1837:Journal of Psychiatric Research
1977:10.1002/14651858.CD005121.pub3
1515:Dinarello CA (December 1994).
663:interleukin-1 receptor binding
605:More reference expression data
560:More reference expression data
1:
2242:10.1158/1055-9965.EPI-06-0267
2192:10.1016/S1359-6101(02)00020-5
2042:10.1016/j.heliyon.2023.e14960
1935:10.3390/pharmaceutics14091785
1849:10.1016/S0022-3956(03)00072-4
1591:10.1016/j.febslet.2006.10.061
1326:The cytoplasmic and secreted
327:
226:
1459:10.1016/0888-7543(92)90137-H
1348:treatment of equine lameness
1315:is used in the treatment of
4774:Genes on human chromosome 2
3852:Antisense oligonucleotides:
2130:Annual Review of Immunology
2004:. Swedish Orphan Biovitrum.
1534:10.1096/fasebj.8.15.8001745
1266:) and interleukin 1, beta (
4795:
2092:10.1007/s00441-022-03726-6
1658:10.1359/jbmr.2000.15.3.402
745:response to glucocorticoid
3359:Colony-stimulating factor
2318:
1428:"Mouse PubMed Reference:"
1410:"Human PubMed Reference:"
1206:
1201:
1197:
1190:
1174:
1155:
1132:
1111:
1080:
1057:
1036:
1005:
992:
988:
973:
969:
960:
947:
943:
928:
924:
915:
902:
898:
883:
879:
870:
855:
848:
844:
828:
623:
619:
602:
579:
570:
557:
506:
497:
444:
435:
405:
397:
393:
376:
363:
326:
305:
296:
292:
275:
262:
225:
202:
193:
189:
144:
141:
131:
124:
119:
84:
79:
62:
57:
52:
48:
39:
34:
3394:proinflammatory cytokine
2277:Medical Subject Headings
2080:Cell and Tissue Research
1291:autoinflammatory disease
1161:Chr 2: 113.1 – 113.13 Mb
4542:Interleukin-29 (IFN-λ1)
3687:Daclizumab (dacliximab)
3672:Tucotuzumab celmoleukin
1332:squamous cell carcinoma
1168:Chr 2: 24.23 – 24.24 Mb
4523:Interferon λ4 (IFN-λ4)
3616:Rilonacept (IL-1 Trap)
2525:/PARC/DCCK1/AMAC1/MIP4
1494:10.1006/geno.1993.1025
1285:Biallelic deleterious
1243:interleukin-1 receptor
4446:Interleukin 23 (SGRF)
4127:Cintredekin besudotox
4055:Interleukin 11 (AGIF)
4034:Interleukin 10 (CSIF)
1761:10.1056/NEJMoa0807865
1274:Clinical significance
795:neutrophil chemotaxis
770:inflammatory response
714:extracellular exosome
514:stroma of bone marrow
452:palpebral conjunctiva
3520:Interleukin receptor
1794:Psychiatric Genetics
1317:rheumatoid arthritis
755:acute-phase response
709:extracellular region
538:skin of external ear
360:2 A3|2 16.36 cM
321:Chromosome 2 (mouse)
219:Chromosome 2 (human)
80:List of PDB id codes
53:Available structures
3652:Denileukin diftitox
3090:Interferon type III
2209:Anticancer Research
2033:2023Heliy...914960D
1706:2000Natur.404..398E
1582:2006FEBSL.580.6289P
719:extracellular space
546:conjunctival fornix
468:gingival epithelium
4224:E (interleukin 25)
950:ENSMUSG00000026981
728:Biological process
682:Cellular component
631:Molecular function
448:buccal mucosa cell
4761:
4760:
4757:
4756:
4726:(signals through
4707:(signals through
4693:(signals through
4683:(signals through
4307:Binding proteins:
3637:Adargileukin alfa
3486:
3485:
3379:
3378:
3337:
3336:
3234:
3233:
3230:
3229:
3038:
3037:
2716:
2715:
2371:
2370:
2236:(10): 1920–1928.
2215:(6A): 3421–3424.
1873:Bipolar Disorders
1755:(23): 2426–2437.
1700:(6776): 398–402.
1576:(27): 6289–6294.
1527:(15): 1314–1325.
1217:
1216:
1213:
1212:
1186:
1185:
1151:
1150:
1122:
1121:
1076:
1075:
1047:
1046:
1001:
1000:
982:
981:
956:
955:
937:
936:
911:
910:
892:
891:
840:
839:
750:insulin secretion
668:cytokine activity
615:
614:
611:
610:
566:
565:
553:
552:
491:
490:
476:periodontal fiber
456:mucosa of pharynx
389:
388:
288:
287:
183:IL1RN - orthologs
115:
114:
111:
110:
63:Ortholog search:
16:(Redirected from
4786:
4749:Efineptakin alfa
4744:Efavaleukin alfa
4646:
3613:Decoy receptors:
3513:
3506:
3499:
3490:
3117:
3049:
2832:
2817:
2429:
2420:
2398:
2391:
2384:
2375:
2357:
2342:
2327:
2307:
2300:
2293:
2284:
2261:
2224:
2203:
2186:(4–5): 323–340.
2174:
2153:
2114:
2113:
2103:
2071:
2065:
2064:
2054:
2044:
2012:
2006:
2005:
2003:
1995:
1989:
1988:
1964:
1958:
1957:
1947:
1937:
1913:
1907:
1906:
1896:
1867:
1861:
1860:
1832:
1826:
1825:
1789:
1783:
1782:
1772:
1740:
1734:
1733:
1714:10.1038/35006081
1685:
1679:
1678:
1660:
1636:
1630:
1629:
1618:
1612:
1611:
1593:
1561:
1555:
1554:
1536:
1512:
1506:
1505:
1477:
1471:
1470:
1442:
1436:
1435:
1424:
1418:
1417:
1406:
1400:
1390:
1379:
1369:
1199:
1198:
1170:
1163:
1146:
1126:
1117:
1085:
1081:RefSeq (protein)
1071:
1051:
1042:
1010:
986:
967:
941:
922:
896:
877:
846:
780:fever generation
740:lipid metabolism
621:
607:
598:
591:
584:
577:
562:
502:
500:Top expressed in
495:
440:
438:Top expressed in
433:
412:
395:
385:
372:
361:
346:
339:
333:
322:
310:
294:
284:
271:
260:
245:
238:
232:
221:
207:
191:
185:
136:
129:
106:
77:
71:
50:
49:
44:
32:
21:
4794:
4793:
4789:
4788:
4787:
4785:
4784:
4783:
4764:
4763:
4762:
4753:
4664:
4637:
4588:
4567:
4546:
4506:
4485:
4429:
4426:(against IL-22)
4397:
4356:
4353:(against IL-20)
4314:
4268:
4187:
4161:
4105:
4064:
4038:
4012:
3981:
3961:
3940:
3859:
3798:
3742:
3696:
3620:
3525:
3517:
3487:
3482:
3448:
3427:
3385:
3375:
3333:
3306:
3226:
3208:
3106:
3034:
3003:
2966:
2904:
2876:
2827:
2825:
2823:
2806:
2712:
2691:
2675:
2578:
2411:
2402:
2372:
2367:
2364:
2358:
2349:
2343:
2334:
2328:
2314:
2311:
2269:
2264:
2227:
2206:
2177:
2156:
2127:
2123:
2121:Further reading
2118:
2117:
2073:
2072:
2068:
2014:
2013:
2009:
2001:
1997:
1996:
1992:
1971:(1): CD005121.
1966:
1965:
1961:
1915:
1914:
1910:
1869:
1868:
1864:
1834:
1833:
1829:
1791:
1790:
1786:
1742:
1741:
1737:
1687:
1686:
1682:
1638:
1637:
1633:
1620:
1619:
1615:
1563:
1562:
1558:
1514:
1513:
1509:
1479:
1478:
1474:
1444:
1443:
1439:
1426:
1425:
1421:
1408:
1407:
1403:
1391:
1382:
1370:
1361:
1356:
1344:
1276:
1255:
1208:View/Edit Mouse
1203:View/Edit Human
1166:
1159:
1156:Location (UCSC)
1142:
1138:
1134:
1113:
1107:
1103:
1099:
1095:
1091:
1067:
1063:
1059:
1038:
1032:
1028:
1024:
1020:
1016:
931:ENSG00000136689
824:
775:immune response
723:
699:plasma membrane
677:
648:protein binding
603:
593:
592:
586:
585:
558:
549:
544:
542:skin of abdomen
540:
536:
532:
528:
524:
520:
516:
512:
498:
487:
484:skin of abdomen
482:
478:
474:
470:
466:
462:
458:
454:
450:
436:
380:
367:
359:
349:
348:
347:
340:
320:
297:Gene location (
279:
266:
258:
248:
247:
246:
239:
217:
194:Gene location (
145:
132:
125:
86:
64:
28:
23:
22:
15:
12:
11:
5:
4792:
4790:
4782:
4781:
4776:
4766:
4765:
4759:
4758:
4755:
4754:
4752:
4751:
4746:
4737:
4736:
4734:Interleukin 35
4731:
4724:Interleukin 34
4721:
4719:Interleukin 32
4716:
4705:Interleukin 26
4702:
4691:Interleukin 24
4688:
4681:Interleukin 16
4678:
4672:
4670:
4666:
4665:
4663:
4662:
4654:
4652:
4643:
4639:
4638:
4636:
4635:
4626:
4625:
4623:Interleukin 38
4620:
4605:Interleukin 36
4598:
4596:
4590:
4589:
4587:
4586:
4584:Interleukin 33
4577:
4575:
4569:
4568:
4566:
4565:
4563:Interleukin 31
4556:
4554:
4548:
4547:
4545:
4544:
4539:
4528:Interleukin 28
4525:
4516:
4514:
4508:
4507:
4505:
4504:
4495:
4493:
4487:
4486:
4484:
4483:
4478:
4473:
4468:
4463:
4458:
4449:
4448:
4439:
4437:
4431:
4430:
4428:
4427:
4417:
4416:
4414:Interleukin 22
4407:
4405:
4399:
4398:
4396:
4395:
4390:
4381:
4380:
4378:Interleukin 21
4375:
4366:
4364:
4358:
4357:
4355:
4354:
4344:
4343:
4341:Interleukin 24
4338:
4336:Interleukin 20
4333:
4331:Interleukin 19
4324:
4322:
4316:
4315:
4313:
4312:
4303:
4302:
4297:
4295:Interleukin 37
4292:
4290:Interleukin 18
4287:
4278:
4276:
4270:
4269:
4267:
4266:
4261:
4256:
4251:
4246:
4241:
4232:
4231:
4204:Interleukin 17
4197:
4195:
4189:
4188:
4186:
4185:
4183:Interleukin 15
4180:
4171:
4169:
4163:
4162:
4160:
4159:
4154:
4149:
4140:
4139:
4137:Interleukin 13
4134:
4129:
4124:
4115:
4113:
4107:
4106:
4104:
4103:
4098:
4089:
4088:
4086:Interleukin 12
4083:
4074:
4072:
4066:
4065:
4063:
4062:
4057:
4048:
4046:
4040:
4039:
4037:
4036:
4031:
4022:
4020:
4014:
4013:
4011:
4010:
4001:
4000:
3991:
3989:
3983:
3982:
3980:
3979:
3971:
3969:
3963:
3962:
3960:
3959:
3950:
3948:
3942:
3941:
3939:
3938:
3933:
3928:
3923:
3918:
3913:
3908:
3903:
3898:
3893:
3884:
3883:
3878:
3869:
3867:
3861:
3860:
3858:
3857:
3848:
3847:
3842:
3837:
3828:
3827:
3818:
3817:
3808:
3806:
3800:
3799:
3797:
3796:
3791:
3782:
3781:
3772:
3771:
3769:Interleukin 13
3766:
3761:
3752:
3750:
3744:
3743:
3741:
3740:
3738:Promegapoietin
3735:
3730:
3725:
3720:
3715:
3706:
3704:
3698:
3697:
3695:
3694:
3689:
3684:
3675:
3674:
3669:
3664:
3662:Pegaldesleukin
3659:
3654:
3649:
3644:
3639:
3630:
3628:
3622:
3621:
3619:
3618:
3609:
3608:
3603:
3598:
3589:
3588:
3583:
3578:
3573:
3564:
3563:
3558:
3553:
3535:
3533:
3527:
3526:
3518:
3516:
3515:
3508:
3501:
3493:
3484:
3483:
3481:
3480:
3479:
3478:
3477:
3476:
3471:
3466:
3461:
3456:
3446:
3442:
3441:
3440:
3435:
3425:
3416:
3410:
3409:
3408:
3407:
3402:
3389:
3387:
3381:
3380:
3377:
3376:
3374:
3373:
3368:
3363:
3362:
3361:
3356:
3345:
3343:
3339:
3338:
3335:
3334:
3332:
3331:
3316:
3314:
3308:
3307:
3305:
3304:
3299:
3294:
3289:
3284:
3279:
3274:
3269:
3264:
3259:
3254:
3244:
3242:
3240:Ig superfamily
3236:
3235:
3232:
3231:
3228:
3227:
3225:
3224:
3218:
3216:
3210:
3209:
3207:
3206:
3201:
3196:
3191:
3186:
3181:
3176:
3171:
3166:
3161:
3156:
3151:
3146:
3141:
3136:
3131:
3125:
3123:
3114:
3108:
3107:
3105:
3104:
3103:
3102:
3097:
3087:
3082:
3077:
3072:
3067:
3057:
3055:
3046:
3040:
3039:
3036:
3035:
3033:
3032:
3027:
3022:
3017:
3011:
3009:
3005:
3004:
3002:
3001:
2996:
2991:
2986:
2980:
2978:
2968:
2967:
2965:
2964:
2963:
2962:
2957:
2952:
2947:
2936:
2931:
2926:
2921:
2915:
2913:
2906:
2905:
2903:
2902:
2897:
2892:
2886:
2884:
2878:
2877:
2875:
2874:
2869:
2864:
2859:
2850:
2840:
2838:
2829:
2814:
2808:
2807:
2805:
2804:
2799:
2794:
2789:
2784:
2779:
2774:
2769:
2764:
2759:
2754:
2749:
2748:
2747:
2742:
2732:
2726:
2724:
2718:
2717:
2714:
2713:
2711:
2710:
2705:
2699:
2697:
2693:
2692:
2690:
2689:
2683:
2681:
2677:
2676:
2674:
2673:
2668:
2663:
2658:
2653:
2648:
2643:
2638:
2633:
2628:
2623:
2618:
2613:
2608:
2603:
2598:
2593:
2586:
2584:
2580:
2579:
2577:
2576:
2571:
2566:
2561:
2556:
2551:
2546:
2541:
2536:
2531:
2526:
2520:
2515:
2510:
2505:
2500:
2495:
2490:
2485:
2480:
2475:
2470:
2465:
2459:
2453:
2447:
2441:
2435:
2433:
2426:
2417:
2413:
2412:
2405:Cell signaling
2403:
2401:
2400:
2393:
2386:
2378:
2369:
2368:
2366:
2365:
2359:
2352:
2350:
2344:
2337:
2335:
2329:
2322:
2319:
2316:
2315:
2312:
2310:
2309:
2302:
2295:
2287:
2281:
2280:
2268:
2267:External links
2265:
2263:
2262:
2225:
2204:
2175:
2165:(3): 256–266.
2154:
2124:
2122:
2119:
2116:
2115:
2086:(3): 523–544.
2066:
2007:
1990:
1959:
1908:
1879:(7): 726–734.
1862:
1843:(6): 457–462.
1827:
1800:(3): 165–167.
1784:
1735:
1680:
1651:(3): 402–414.
1631:
1613:
1556:
1507:
1488:(1): 173–176.
1472:
1453:(3): 654–657.
1437:
1419:
1401:
1380:
1358:
1357:
1355:
1352:
1343:
1340:
1306:osteoarthritis
1280:gastric cancer
1275:
1272:
1254:
1251:
1215:
1214:
1211:
1210:
1205:
1195:
1194:
1188:
1187:
1184:
1183:
1181:
1179:
1172:
1171:
1164:
1157:
1153:
1152:
1149:
1148:
1130:
1129:
1123:
1120:
1119:
1109:
1108:
1082:
1078:
1077:
1074:
1073:
1055:
1054:
1048:
1045:
1044:
1034:
1033:
1007:
1003:
1002:
999:
998:
990:
989:
983:
980:
979:
971:
970:
964:
958:
957:
954:
953:
945:
944:
938:
935:
934:
926:
925:
919:
913:
912:
909:
908:
900:
899:
893:
890:
889:
881:
880:
874:
868:
867:
862:
857:
853:
852:
842:
841:
838:
837:
826:
825:
823:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
731:
729:
725:
724:
722:
721:
716:
711:
706:
701:
696:
691:
685:
683:
679:
678:
676:
675:
670:
665:
660:
655:
650:
645:
640:
634:
632:
628:
627:
617:
616:
613:
612:
609:
608:
600:
599:
574:
568:
567:
564:
563:
555:
554:
551:
550:
548:
547:
543:
539:
535:
531:
527:
523:
519:
515:
511:
507:
504:
503:
492:
489:
488:
486:
485:
481:
480:amniotic fluid
477:
473:
472:body of tongue
469:
465:
461:
457:
453:
449:
445:
442:
441:
429:
428:
420:
409:
403:
402:
399:RNA expression
391:
390:
387:
386:
378:
374:
373:
365:
362:
357:
351:
350:
341:
334:
328:
324:
323:
318:
312:
311:
303:
302:
290:
289:
286:
285:
277:
273:
272:
264:
261:
256:
250:
249:
240:
233:
227:
223:
222:
215:
209:
208:
200:
199:
187:
186:
143:
139:
138:
130:
122:
121:
117:
116:
113:
112:
109:
108:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4791:
4780:
4777:
4775:
4772:
4771:
4769:
4750:
4747:
4745:
4742:
4739:
4738:
4735:
4732:
4729:
4725:
4722:
4720:
4717:
4714:
4710:
4706:
4703:
4700:
4696:
4692:
4689:
4686:
4682:
4679:
4677:
4674:
4673:
4671:
4667:
4660:
4656:
4655:
4653:
4651:
4647:
4644:
4640:
4634:
4631:
4628:
4627:
4624:
4621:
4618:
4614:
4610:
4606:
4603:
4600:
4599:
4597:
4595:
4591:
4585:
4582:
4579:
4578:
4576:
4574:
4570:
4564:
4561:
4558:
4557:
4555:
4553:
4549:
4543:
4540:
4537:
4533:
4529:
4526:
4524:
4521:
4518:
4517:
4515:
4513:
4509:
4503:
4500:
4497:
4496:
4494:
4492:
4488:
4482:
4479:
4477:
4476:Tildrakizumab
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4457:
4454:
4451:
4450:
4447:
4444:
4441:
4440:
4438:
4436:
4432:
4425:
4422:
4419:
4418:
4415:
4412:
4409:
4408:
4406:
4404:
4400:
4394:
4391:
4389:
4386:
4383:
4382:
4379:
4376:
4374:
4371:
4368:
4367:
4365:
4363:
4359:
4352:
4349:
4346:
4345:
4342:
4339:
4337:
4334:
4332:
4329:
4326:
4325:
4323:
4321:
4317:
4311:
4308:
4305:
4304:
4301:
4298:
4296:
4293:
4291:
4288:
4286:
4283:
4280:
4279:
4277:
4275:
4271:
4265:
4262:
4260:
4257:
4255:
4252:
4250:
4247:
4245:
4242:
4240:
4237:
4234:
4233:
4229:
4225:
4221:
4217:
4213:
4209:
4205:
4202:
4199:
4198:
4196:
4194:
4190:
4184:
4181:
4179:
4176:
4173:
4172:
4170:
4168:
4164:
4158:
4155:
4153:
4150:
4148:
4145:
4142:
4141:
4138:
4135:
4133:
4132:Interleukin 4
4130:
4128:
4125:
4123:
4120:
4117:
4116:
4114:
4112:
4108:
4102:
4099:
4097:
4094:
4091:
4090:
4087:
4084:
4082:
4081:Edodekin alfa
4079:
4076:
4075:
4073:
4071:
4067:
4061:
4058:
4056:
4053:
4050:
4049:
4047:
4045:
4041:
4035:
4032:
4030:
4027:
4024:
4023:
4021:
4019:
4015:
4009:
4006:
4003:
4002:
3999:
3998:Interleukin 9
3996:
3993:
3992:
3990:
3988:
3984:
3977:
3973:
3972:
3970:
3968:
3964:
3958:
3957:Interleukin 7
3955:
3952:
3951:
3949:
3947:
3943:
3937:
3934:
3932:
3929:
3927:
3924:
3922:
3919:
3917:
3914:
3912:
3909:
3907:
3904:
3902:
3899:
3897:
3894:
3892:
3889:
3886:
3885:
3882:
3881:Interleukin 6
3879:
3877:
3876:Atexakin alfa
3874:
3871:
3870:
3868:
3866:
3862:
3856:
3853:
3850:
3849:
3846:
3843:
3841:
3838:
3836:
3833:
3830:
3829:
3826:
3823:
3820:
3819:
3816:
3815:Interleukin 5
3813:
3810:
3809:
3807:
3805:
3801:
3795:
3792:
3790:
3787:
3784:
3783:
3780:
3777:
3774:
3773:
3770:
3767:
3765:
3764:Interleukin 4
3762:
3760:
3757:
3754:
3753:
3751:
3749:
3745:
3739:
3736:
3734:
3731:
3729:
3726:
3724:
3721:
3719:
3718:Interleukin 3
3716:
3714:
3711:
3708:
3707:
3705:
3703:
3699:
3693:
3690:
3688:
3685:
3683:
3680:
3677:
3676:
3673:
3670:
3668:
3665:
3663:
3660:
3658:
3657:Interleukin 2
3655:
3653:
3650:
3648:
3645:
3643:
3640:
3638:
3635:
3632:
3631:
3629:
3627:
3623:
3617:
3614:
3611:
3610:
3607:
3604:
3602:
3599:
3597:
3594:
3591:
3590:
3587:
3584:
3582:
3579:
3577:
3574:
3572:
3569:
3566:
3565:
3562:
3559:
3557:
3554:
3551:
3547:
3543:
3542:Interleukin 1
3540:
3537:
3536:
3534:
3532:
3528:
3524:
3521:
3514:
3509:
3507:
3502:
3500:
3495:
3494:
3491:
3475:
3472:
3470:
3467:
3465:
3462:
3460:
3457:
3455:
3452:
3451:
3450:
3443:
3439:
3436:
3434:
3431:
3430:
3429:
3422:
3421:
3420:
3417:
3415:
3412:
3411:
3406:
3403:
3401:
3398:
3397:
3396:
3395:
3391:
3390:
3388:
3382:
3372:
3369:
3367:
3364:
3360:
3357:
3355:
3352:
3351:
3350:
3349:Hematopoietic
3347:
3346:
3344:
3340:
3329:
3325:
3321:
3318:
3317:
3315:
3313:
3309:
3303:
3300:
3298:
3295:
3293:
3290:
3288:
3285:
3283:
3280:
3278:
3275:
3273:
3270:
3268:
3265:
3263:
3260:
3258:
3255:
3253:
3249:
3246:
3245:
3243:
3241:
3237:
3223:
3220:
3219:
3217:
3215:
3211:
3205:
3202:
3200:
3197:
3195:
3192:
3190:
3187:
3185:
3182:
3180:
3177:
3175:
3172:
3170:
3167:
3165:
3162:
3160:
3157:
3155:
3152:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3127:
3126:
3124:
3122:
3118:
3115:
3113:
3109:
3101:
3098:
3096:
3093:
3092:
3091:
3088:
3086:
3083:
3081:
3078:
3076:
3073:
3071:
3068:
3066:
3062:
3059:
3058:
3056:
3054:
3050:
3047:
3045:
3041:
3031:
3028:
3026:
3023:
3021:
3018:
3016:
3013:
3012:
3010:
3006:
3000:
2997:
2995:
2992:
2990:
2987:
2985:
2982:
2981:
2979:
2977:
2973:
2969:
2961:
2958:
2956:
2953:
2951:
2948:
2946:
2942:
2941:
2940:
2937:
2935:
2932:
2930:
2927:
2925:
2922:
2920:
2917:
2916:
2914:
2912:
2907:
2901:
2898:
2896:
2893:
2891:
2888:
2887:
2885:
2883:
2879:
2873:
2870:
2868:
2865:
2863:
2860:
2858:
2854:
2851:
2849:
2845:
2842:
2841:
2839:
2837:
2833:
2830:
2822:
2818:
2815:
2813:
2809:
2803:
2800:
2798:
2795:
2793:
2790:
2788:
2785:
2783:
2780:
2778:
2775:
2773:
2770:
2768:
2765:
2763:
2760:
2758:
2757:TNFSF5/CD40LG
2755:
2753:
2750:
2746:
2743:
2741:
2738:
2737:
2736:
2733:
2731:
2728:
2727:
2725:
2723:
2719:
2709:
2706:
2704:
2701:
2700:
2698:
2694:
2688:
2685:
2684:
2682:
2678:
2672:
2669:
2667:
2664:
2662:
2659:
2657:
2654:
2652:
2649:
2647:
2644:
2642:
2639:
2637:
2634:
2632:
2629:
2627:
2624:
2622:
2619:
2617:
2614:
2612:
2609:
2607:
2604:
2602:
2599:
2597:
2594:
2591:
2588:
2587:
2585:
2581:
2575:
2572:
2570:
2567:
2565:
2562:
2560:
2557:
2555:
2552:
2550:
2547:
2545:
2542:
2540:
2537:
2535:
2532:
2530:
2527:
2524:
2521:
2519:
2516:
2514:
2511:
2509:
2506:
2504:
2501:
2499:
2496:
2494:
2491:
2489:
2486:
2484:
2481:
2479:
2476:
2474:
2471:
2469:
2466:
2463:
2460:
2457:
2454:
2451:
2448:
2445:
2442:
2440:
2437:
2436:
2434:
2430:
2427:
2425:
2421:
2418:
2414:
2410:
2406:
2399:
2394:
2392:
2387:
2385:
2380:
2379:
2376:
2362:
2356:
2351:
2347:
2341:
2336:
2332:
2326:
2321:
2317:
2308:
2303:
2301:
2296:
2294:
2289:
2288:
2285:
2278:
2274:
2271:
2270:
2266:
2259:
2255:
2251:
2247:
2243:
2239:
2235:
2231:
2226:
2222:
2218:
2214:
2210:
2205:
2201:
2197:
2193:
2189:
2185:
2181:
2176:
2172:
2168:
2164:
2160:
2155:
2151:
2147:
2143:
2139:
2135:
2131:
2126:
2125:
2120:
2111:
2107:
2102:
2097:
2093:
2089:
2085:
2081:
2077:
2070:
2067:
2062:
2058:
2053:
2048:
2043:
2038:
2034:
2030:
2027:(4): e14960.
2026:
2022:
2018:
2011:
2008:
2000:
1994:
1991:
1986:
1982:
1978:
1974:
1970:
1963:
1960:
1955:
1951:
1946:
1941:
1936:
1931:
1927:
1923:
1922:Pharmaceutics
1919:
1912:
1909:
1904:
1900:
1895:
1890:
1886:
1882:
1878:
1874:
1866:
1863:
1858:
1854:
1850:
1846:
1842:
1838:
1831:
1828:
1823:
1819:
1815:
1811:
1807:
1803:
1799:
1795:
1788:
1785:
1780:
1776:
1771:
1766:
1762:
1758:
1754:
1750:
1746:
1739:
1736:
1731:
1727:
1723:
1719:
1715:
1711:
1707:
1703:
1699:
1695:
1691:
1684:
1681:
1676:
1672:
1668:
1664:
1659:
1654:
1650:
1646:
1642:
1635:
1632:
1627:
1623:
1617:
1614:
1609:
1605:
1601:
1597:
1592:
1587:
1583:
1579:
1575:
1571:
1567:
1560:
1557:
1552:
1548:
1544:
1540:
1535:
1530:
1526:
1522:
1521:FASEB Journal
1518:
1511:
1508:
1503:
1499:
1495:
1491:
1487:
1483:
1476:
1473:
1468:
1464:
1460:
1456:
1452:
1448:
1441:
1438:
1433:
1429:
1423:
1420:
1415:
1411:
1405:
1402:
1398:
1394:
1389:
1387:
1385:
1381:
1377:
1373:
1368:
1366:
1364:
1360:
1353:
1351:
1349:
1342:Use in horses
1341:
1339:
1337:
1333:
1329:
1324:
1322:
1318:
1314:
1309:
1308:progression.
1307:
1303:
1302:messenger RNA
1298:
1296:
1292:
1288:
1283:
1281:
1273:
1271:
1269:
1265:
1260:
1252:
1250:
1248:
1247:interleukin 1
1244:
1239:
1237:
1234:
1230:
1226:
1222:
1209:
1204:
1200:
1196:
1193:
1189:
1182:
1180:
1177:
1173:
1169:
1165:
1162:
1158:
1154:
1147:
1145:
1141:
1137:
1131:
1127:
1124:
1118:
1116:
1110:
1106:
1102:
1098:
1094:
1090:
1086:
1083:
1079:
1072:
1070:
1066:
1062:
1056:
1052:
1049:
1043:
1041:
1035:
1031:
1027:
1023:
1019:
1015:
1011:
1008:
1006:RefSeq (mRNA)
1004:
997:
996:
991:
987:
984:
978:
977:
972:
968:
965:
963:
959:
952:
951:
946:
942:
939:
933:
932:
927:
923:
920:
918:
914:
907:
906:
901:
897:
894:
888:
887:
882:
878:
875:
873:
869:
866:
863:
861:
858:
854:
851:
847:
843:
836:
832:
827:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
732:
730:
727:
726:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
686:
684:
681:
680:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
635:
633:
630:
629:
626:
625:Gene ontology
622:
618:
606:
601:
597:
590:
583:
578:
575:
573:
569:
561:
556:
545:
541:
537:
533:
529:
525:
521:
517:
513:
509:
508:
505:
501:
496:
493:
483:
479:
475:
471:
467:
463:
459:
455:
451:
447:
446:
443:
439:
434:
431:
430:
427:
425:
421:
419:
418:
414:
413:
410:
408:
404:
400:
396:
392:
384:
379:
375:
371:
366:
356:
352:
345:
338:
332:
325:
317:
313:
309:
304:
300:
295:
291:
283:
278:
274:
270:
265:
255:
251:
244:
237:
231:
224:
220:
214:
210:
206:
201:
197:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
140:
135:
128:
123:
118:
107:
105:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
30:
19:
4740:
4728:M-CSFR/CSF1R
4715:heterodimer)
4701:heterodimer)
4630:Antagonists:
4629:
4601:
4580:
4559:
4519:
4498:
4471:Risankizumab
4452:
4442:
4420:
4410:
4393:NNC0114-0006
4388:NNC0114-0005
4384:
4369:
4347:
4327:
4306:
4281:
4235:
4200:
4174:
4157:Tralokinumab
4152:Lebrikizumab
4147:Anrukinzumab
4143:
4118:
4092:
4077:
4051:
4025:
4004:
3994:
3953:
3896:Clazakizumab
3887:
3872:
3851:
3835:Benralizumab
3831:
3822:Antagonists:
3821:
3811:
3794:Pascolizumab
3785:
3776:Antagonists:
3775:
3755:
3709:
3678:
3633:
3612:
3592:
3568:Antagonists:
3567:
3538:
3444:
3423:
3392:
3384:By function/
3095:IL28/IFNL2+3
2360:
2345:
2330:
2233:
2229:
2212:
2208:
2183:
2179:
2162:
2158:
2133:
2129:
2083:
2079:
2069:
2024:
2020:
2010:
1993:
1968:
1962:
1925:
1921:
1911:
1876:
1872:
1865:
1840:
1836:
1830:
1797:
1793:
1787:
1752:
1748:
1738:
1697:
1693:
1683:
1648:
1644:
1634:
1625:
1616:
1573:
1570:FEBS Letters
1569:
1559:
1524:
1520:
1510:
1485:
1481:
1475:
1450:
1446:
1440:
1431:
1422:
1413:
1404:
1345:
1325:
1310:
1299:
1284:
1277:
1256:
1240:
1232:
1224:
1220:
1218:
1140:NP_001153034
1136:NP_001034790
1133:
1115:NP_001366289
1112:
1093:NP_001305843
1065:NM_001159562
1061:NM_001039701
1058:
1040:NM_001379360
1037:
1030:NM_001318914
993:
974:
948:
929:
903:
884:
864:
859:
534:skin of back
422:
415:
280:113,134,016
267:113,099,315
142:External IDs
85:
29:
4481:Ustekinumab
4461:Briakinumab
4453:Antibodies:
4424:Fezakinumab
4421:Antibodies:
4385:Antibodies:
4373:Denenicokin
4348:Antibodies:
4285:Iboctadekin
4264:Vunakizumab
4259:Secukinumab
4249:Perakizumab
4236:Antibodies:
4144:Antibodies:
4101:Ustekinumab
4096:Briakinumab
4093:Antibodies:
4005:Antibodies:
3931:Tocilizumab
3901:Elsilimomab
3888:Antibodies:
3840:Mepolizumab
3832:Antibodies:
3786:Antibodies:
3713:Daniplestim
3682:Basiliximab
3679:Antibodies:
3647:Celmoleukin
3642:Aldesleukin
3606:Lutikizumab
3601:Gevokizumab
3596:Canakinumab
3593:Antibodies:
3312:IL17 family
3053:IL10 family
2972:IL12 family
2824:(grouped by
2812:Interleukin
2735:Lymphotoxin
2313:PDB gallery
1928:(9): 1785.
1894:10852/34620
1626:Entrez Gene
510:granulocyte
464:oral cavity
381:24,241,506
368:24,226,865
120:Identifiers
4768:Categories
4536:B (IFN-λ3)
4532:A (IFN-λ2)
4466:Guselkumab
4456:Brazikumab
4351:Fletikumab
4254:Remtolumab
4244:Ixekizumab
4239:Brodalumab
4122:Binetrakin
4060:Oprelvekin
4029:Ilodecakin
4008:Enokizumab
3921:Siltuximab
3911:Olokizumab
3845:Reslizumab
3779:Pitrakinra
3759:Binetrakin
3728:Milodistim
3723:Leridistim
3692:Inolimomab
3667:Teceleukin
3586:Isunakinra
3523:modulators
3419:Lymphokine
3257:IL1B/IL1F2
3252:IL1A/IL1F1
3248:IL1 family
3112:Interferon
3100:IL29/IFNL1
1399:, May 2017
1378:, May 2017
1354:References
1336:glycolysis
1321:autoimmune
530:left colon
426:(ortholog)
163:HomoloGene
4779:Cytokines
4741:Unsorted:
4602:Agonists:
4581:Agonists:
4560:Agonists:
4520:Agonists:
4499:Agonists:
4443:Agonists:
4411:Agonists:
4370:Agonists:
4328:Agonists:
4300:Tadekinig
4282:Agonists:
4201:Agonists:
4175:Agonists:
4119:Agonists:
4078:Agonists:
4052:Agonists:
4026:Agonists:
3995:Agonists:
3954:Agonists:
3936:Levilimab
3926:Sirukumab
3916:Sarilumab
3873:Agonists:
3812:Agonists:
3789:Dupilumab
3756:Agonists:
3733:Muplestim
3710:Agonists:
3634:Agonists:
3561:Pifonakin
3556:Mobenakin
3539:Agonists:
3297:33/IL1F11
3262:1Ra/IL1F3
2909:IL6 like/
2626:CXCL8/IL8
2424:Chemokine
2416:By family
2409:cytokines
2136:: 27–55.
1287:mutations
1144:NP_112444
1105:NP_776215
1101:NP_776214
1097:NP_776213
1089:NP_000568
1069:NM_031167
1026:NM_173843
1022:NM_173842
1018:NM_173841
1014:NM_000577
850:Orthologs
689:cytoplasm
522:esophagus
171:GeneCards
4695:IL-22Rα1
4661:instead.
3978:instead.
3906:mAb 1339
3891:ARGX-109
3855:TPI ASM8
3825:YM-90709
3576:Anakinra
3571:AF-12198
3414:Monokine
2943:+non IL
2828:subunit)
2826:receptor
2797:TNFSF13B
2745:TNFC/LTB
2740:TNFB/LTA
2250:17035400
2221:12530098
2200:12220547
2171:10948677
2110:36543895
2061:37025835
2052:10070157
1985:19160248
1954:36145533
1903:19839997
1857:14563376
1822:43435475
1814:15318032
1779:19494218
1722:10746728
1675:23035139
1667:10750554
1608:23087836
1600:17097645
1551:10404996
1482:Genomics
1447:Genomics
1395:–
1374:–
1328:isoforms
1313:anakinra
1259:cytokine
1253:Function
1192:Wikidata
829:Sources:
4713:IL-10Rβ
4709:IL-20Rα
4699:IL-20Rβ
4633:IL-36RA
4178:ALT-803
3302:18/IL1G
3044:Type II
2976:IL12RB1
2882:β chain
2836:γ chain
2792:TNFSF13
2787:TNFSF11
2782:TNFSF10
2464:/RANTES
2258:8542733
2150:9597123
2101:9974687
2029:Bibcode
2021:Heliyon
1945:9505648
1770:2876877
1730:1288472
1702:Bibcode
1578:Bibcode
1543:8001745
1502:8432529
1467:1386337
1397:Ensembl
1376:Ensembl
1293:called
1229:protein
1227:) is a
962:UniProt
917:Ensembl
856:Species
835:QuickGO
694:vesicle
401:pattern
127:Aliases
4669:Others
4642:Others
4594:IL1RL2
4573:IL1RL1
4310:IL18BP
3581:IL-1RA
3292:IL1F10
3189:IFNA21
3184:IFNA17
3179:IFNA16
3174:IFNA14
3169:IFNA13
3164:IFNA10
2821:Type I
2777:TNFSF9
2772:TNFSF8
2767:TNFSF7
2762:TNFSF6
2752:TNFSF4
2687:CX3CL1
2671:CXCL17
2666:CXCL16
2661:CXCL15
2656:CXCL14
2651:CXCL13
2646:CXCL12
2641:CXCL11
2636:CXCL10
2458:/MIP1β
2452:/MIP1α
2279:(MeSH)
2256:
2248:
2219:
2198:
2169:
2148:
2108:
2098:
2059:
2049:
1983:
1952:
1942:
1901:
1855:
1820:
1812:
1777:
1767:
1728:
1720:
1694:Nature
1673:
1665:
1606:
1598:
1549:
1541:
1500:
1465:
1225:IL-1RA
1178:search
1176:PubMed
995:P25085
976:P18510
872:Entrez
572:BioGPS
259:2q14.1
151:147679
4552:IL-31
4512:IL-28
4491:IL-27
4435:IL-23
4403:IL-22
4362:IL-21
4320:IL-20
4274:IL-18
4193:IL-17
4167:IL-15
4111:IL-13
4070:IL-12
4044:IL-11
4018:IL-10
3354:KITLG
3342:Other
3328:IL17A
3287:IL1F9
3282:IL1F8
3277:IL1F7
3272:IL1F6
3267:IL1F5
3204:IFNW1
3194:IFNB1
3159:IFNA8
3154:IFNA7
3149:IFNA6
3144:IFNA5
3139:IFNA4
3134:IFNA2
3129:IFNA1
3008:Other
2911:gp130
2900:GMCSF
2680:CX3CL
2631:CXCL9
2621:CXCL7
2616:CXCL6
2611:CXCL5
2606:CXCL4
2601:CXCL3
2596:CXCL2
2590:CXCL1
2574:CCL28
2569:CCL27
2564:CCL26
2559:CCL25
2554:CCL24
2549:CCL23
2544:CCL22
2539:CCL21
2534:CCL20
2529:CCL19
2523:CCL18
2518:CCL17
2513:CCL16
2508:CCL15
2503:CCL14
2498:CCL13
2493:CCL12
2488:CCL11
2446:/MCP1
2254:S2CID
2002:(PDF)
1818:S2CID
1726:S2CID
1671:S2CID
1604:S2CID
1547:S2CID
1319:, an
1233:IL1RN
905:16181
865:Mouse
860:Human
831:Amigo
424:Mouse
417:Human
364:Start
299:Mouse
263:Start
196:Human
175:IL1RN
167:11163
159:96547
134:IL1RN
35:IL1RN
4659:here
4657:See
3987:IL-9
3976:here
3967:IL-8
3946:IL-7
3865:IL-6
3804:IL-5
3748:IL-4
3702:IL-3
3626:IL-2
3531:IL-1
3474:IL13
3469:IL10
3438:TNFβ
3433:IFNγ
3405:TNFA
3386:cell
3366:SPP1
3324:IL25
3320:IL17
3222:IFNG
3199:IFNK
3085:IL26
3080:IL24
3075:IL20
3070:IL19
3065:IL22
3061:IL10
3030:IL34
3025:IL32
3020:IL16
3015:IL14
2999:IL35
2994:IL27
2989:IL23
2984:IL12
2960:CTF1
2955:CNTF
2939:IL31
2934:IL30
2929:IL27
2924:IL11
2872:IL21
2857:IL13
2848:IL15
2730:TNFA
2708:XCL2
2703:XCL1
2583:CXCL
2483:CCL9
2478:CCL8
2473:CCL7
2468:CCL6
2462:CCL5
2456:CCL4
2450:CCL3
2444:CCL2
2439:CCL1
2361:1irp
2346:1ira
2331:1ilr
2246:PMID
2217:PMID
2196:PMID
2167:PMID
2146:PMID
2106:PMID
2057:PMID
1981:PMID
1950:PMID
1899:PMID
1853:PMID
1810:PMID
1775:PMID
1718:PMID
1663:PMID
1596:PMID
1539:PMID
1498:PMID
1463:PMID
1268:IL1B
1264:IL1A
1236:gene
1219:The
886:3557
460:gums
407:Bgee
355:Band
316:Chr.
254:Band
213:Chr.
147:OMIM
104:2IRT
100:1IRP
96:1IRA
92:1ILT
88:1ILR
69:RCSB
66:PDBe
4685:CD4
4650:JAK
3464:IL6
3459:IL5
3454:IL4
3400:IL1
3371:MIF
2950:LIF
2945:OSM
2919:IL6
2895:IL5
2890:IL3
2867:IL9
2862:IL7
2853:IL4
2844:IL2
2802:EDA
2722:TNF
2696:XCL
2592:/KC
2432:CCL
2238:doi
2188:doi
2138:doi
2096:PMC
2088:doi
2084:391
2047:PMC
2037:doi
1973:doi
1940:PMC
1930:doi
1889:hdl
1881:doi
1845:doi
1802:doi
1765:PMC
1757:doi
1753:360
1710:doi
1698:404
1653:doi
1586:doi
1574:580
1529:doi
1490:doi
1455:doi
518:lip
377:End
276:End
179:OMA
155:MGI
59:PDB
4770::
4615:,
4611:,
4534:,
4226:,
4222:,
4218:,
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2035:.
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1979:.
1948:.
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4617:γ
4613:β
4609:α
4607:(
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4530:(
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4228:F
4220:D
4216:C
4212:B
4208:A
4206:(
3552:)
3550:β
3546:α
3544:(
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3505:t
3498:v
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