381:
48:
80:
341:
361:
251:
247:. However, hormonal disturbances, in Leydig tumours, is present in only 2/3 of cases. Testicular Leydig cell tumours can be detected sonographically, ultrasound examinations may be ordered in the event of a palpable scrotal lump, however incidental identification of these lesions is also possible.
313:
In males, a radical inguinal orchiectomy is typically performed. However, testes-sparing surgery can be used to maintain fertility in children and young adults. This approach involves an inguinal or scrotal incision and ultrasound guidance if the tumour is non-palpable. This can be done because the
305:
The usual treatment is surgery. The surgery for females usually is a fertility-sparing unilateral salpingo-oophorectomy. For malignant tumours, the surgery may be radical and usually is followed by adjuvant chemotherapy, sometimes by radiation therapy. In all cases, initial treatment is followed
380:
936:
619:
Ulbright TM, Srigley JR, Hatzianastassiou DK, Young RH (November 2002). "Leydig cell tumors of the testis with unusual features: adipose differentiation, calcification with ossification, and spindle-shaped tumor cells".
278:
are classically found in these tumours and help confirm the diagnosis, although they are seen in less than half of all Leydig cell tumours. Immunohistochemical markers of Leydig cell tumours include
663:
Basciani, Sabrina; Brama, Marina; Mariani, Stefania; De Luca, Gabriele; Arizzi, Mario; Vesci, Loredana; Pisano, Claudio; Dolci, Susanna; Spera, Giovanni; Gnessi, Lucio (2005-03-01).
955:
1037:
386:
Typical gross pathology of a Leydig cell tumor (in this case of the ovary): A well circumscribed, solid homogeneous mass with golden brown to brownish green cut surface.
340:
1563:
902:
542:
Biegel, L. B.; Liu, R. C.; Hurtt, M. E.; Cook, J. C. (1995). "Effects of ammonium perfluorooctanoate on Leydig cell function: in vitro, in vivo, and ex vivo studies".
446:
1840:
461:
Sachdeva P, Arora R, Dubey C, Sukhija A, Daga M, Singh DK (April 2008). "Sertoli-Leydig cell tumor: a rare ovarian neoplasm. Case report and review of literature".
1737:
1732:
360:
1401:
143:
The majority of Leydig cell tumors are found in males, usually at 5–10 years of age or in middle adulthood (30–60 years). Children typically present with
47:
1477:
1386:
799:"Testicular-sparing surgery for bilateral or monorchide testicular tumours: a multicenter study of long-term oncological and functional results"
1030:
845:
1467:
1358:
1556:
1195:
191:
In men, testicular swelling is the most common presenting feature. Other symptoms depend on age and the type of tumour. If it is secreting
1597:
1157:
1744:
1396:
1113:
1381:
1482:
1424:
1023:
797:
Ferretti L, Sargos P, Gross-Goupil M, Izard V, Wallerand H, Huyghe E, Rigot JM, Durand X, Benoit G, Ferriere JM, Droupy S (2014).
1525:
1081:
1825:
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207:, erectile dysfunction, infertility, feminine hair distribution, gonadogenital atrophy, and a loss of libido.
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1749:
1103:
79:
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1223:
1170:
940:
402:
128:
314:
tumour is typically unifocal, not associated with precancerous lesions, and is unlikely to recur.
154:
secreted by the tumour, one-third of female patients present with a recent history of progressive
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1472:
1348:
1340:
1133:
1108:
826:
779:
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601:
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196:
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1267:
203:
it can cause feminisation in young boys. In adults, this causes a number of problems including
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974:
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865:
818:
771:
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637:
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478:
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113:
64:
188:, temporal hair recession, and an increase in musculature. Serum testosterone level is high.
1120:
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1205:
798:
733:
528:
275:
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507:
239:
Presence of an ovarian tumour plus hormonal disturbances suggests a Leydig cell tumour,
1727:
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1459:
1325:
1303:
1233:
1143:
1067:
172:
163:
109:
17:
949:
945:
298:
The usual chemotherapy regimen has limited efficacy in tumours of this type, although
1814:
1772:
1764:
1497:
1487:
1242:
633:
306:
by surveillance. Because in many cases Leydig cell tumour does not produce elevated
279:
185:
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73:
830:
783:
649:
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1213:
307:
250:
204:
151:
132:
689:
664:
371:
351:
263:
56:
968:
752:"Use of novel serum markers in clinical follow-up of Sertoli-Leydig cell tumours"
750:
Lenhard M, Kuemper C, Ditsch N, Diebold J, Stieber P, Friese K, Burges A (2007).
578:
998:
861:
159:
117:
120:. While the tumour can occur at any age, it occurs most often in young adults.
1330:
1312:
979:
474:
367:
347:
283:
255:
167:
329:. For malignant tumours with undifferentiated histology, prognosis is poor.
310:, the focus of surveillance is on repeated physical examination and imaging.
713:"Leydig Cell Tumors Treatment & Management: Medical Care, Surgical Care"
326:
318:
271:
181:
869:
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775:
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641:
555:
482:
767:
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1574:
1510:
1411:
1238:
299:
200:
192:
69:
928:
1190:
1180:
885:"Testis & epididymis - Sex cord-stromal tumors - Leydig cell tumor"
597:
429:"Testis & epididymis - Sex cord-stromal tumors - Leydig cell tumor"
287:
244:
814:
508:"Leydig Cell Tumors: Practice Essentials, Background, Pathophysiology"
322:
321:
is generally good as the tumour tends to grow slowly and usually is
665:"Imatinib Mesylate Inhibits Leydig Cell Tumor Growth: Evidence for
302:
has shown some promise. There is no current role for radiotherapy.
1046:
249:
1545:
1019:
274:, as part of a pathology report made during or after surgery.
579:"Ultrasound of a prepubertal Leydig cell tumour of the testis"
907:
Topic
Completed: 4 March 2021. Minor changes: 12 April 2021.
451:
Topic
Completed: 4 March 2021. Minor changes: 12 April 2021.
55:
Histopathology of a Leydig cell tumor, high magnification,
577:
Reddan, Tristan; Powell, Jennifer; Long, Gillian (2017).
502:
500:
846:"An in-depth look at Leydig cell tumor of the testis"
918:
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1204:
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1057:
989:
922:
63:
37:
32:
195:the tumour is usually asymptomatic, but can cause
215:Animal studies a suggest possible link with C8 (C
127:is a combination of a Leydig cell tumour and a
1733:High-grade prostatic intraepithelial neoplasia
883:Zhengshan Chen, M.D., Ph.D., Manju Aron, M.D.
745:
743:
427:Zhengshan Chen, M.D., Ph.D., Manju Aron, M.D.
1557:
1031:
199:in pre-pubertal boys. If the tumour secretes
8:
901:: CS1 maint: multiple names: authors list (
445:: CS1 maint: multiple names: authors list (
1634:
1593:
1564:
1550:
1542:
1308:
1088:
1072:
1063:
1038:
1024:
1016:
919:
78:
46:
29:
688:
844:Al-Agha OM, Axiotis CA (February 2007).
1478:Clear-cell adenocarcinoma of the vagina
419:
336:
1841:Endocrine-related cutaneous conditions
894:
729:
718:
524:
513:
438:
1468:Squamous-cell carcinoma of the vagina
1359:Endometrial intraepithelial neoplasia
98:(testicular) interstitial cell tumour
7:
1196:Sex cord tumour with annular tubules
102:(testicular) interstitial cell tumor
1745:List of people with prostate cancer
1114:Papillary serous cystadenocarcinoma
544:Toxicology and Applied Pharmacology
270:A conclusive diagnosis is made via
41:Testicular interstitial cell tumour
1382:Cervical intraepithelial neoplasia
1354:Uterine papillary serous carcinoma
104:(US spelling), is a member of the
25:
1483:Vaginal intraepithelial neoplasia
1425:Gestational trophoblastic disease
158:. Masculinization is preceded by
1526:Vulvar intraepithelial neoplasia
634:10.1097/00000478-200211000-00004
379:
359:
339:
1:
1402:Villoglandular adenocarcinoma
690:10.1158/0008-5472.can-04-2181
1778:Extramammary Paget's disease
1521:Extramammary Paget's disease
1364:Uterine clear-cell carcinoma
1139:Ovarian clear-cell carcinoma
398:Androgen-dependent syndromes
1755:Transitional-cell carcinoma
1657:Germ cell neoplasia in situ
862:10.5858/2007-131-311-AILALC
346:Intermediate magnification
176:. Additional signs include
59:, showing typical features.
1857:
1608:Sertoli–Leydig cell tumour
1321:Uterine fibroids/leiomyoma
1176:Sertoli–Leydig cell tumour
1099:Ovarian serous cystadenoma
408:Sertoli–Leydig cell tumour
125:Sertoli–Leydig cell tumour
1800:Hirsuties coronae glandis
1531:Bartholin gland carcinoma
1473:Botryoid rhabdomyosarcoma
1129:
475:10.1080/09513590801953465
370:of a Leydig cell tumour.
350:of a Leydig cell tumour.
54:
45:
1795:Erythroplasia of Queyrat
1158:Sex cord–gonadal stromal
1077:Glandular and epithelial
106:sex cord-stromal tumour
18:Interstitial cell tumor
1826:Male genital neoplasia
1682:Endodermal sinus tumor
1229:Endodermal sinus tumor
850:Arch. Pathol. Lab. Med
728:Cite journal requires
556:10.1006/taap.1995.1164
523:Cite journal requires
267:
229:perfluorooctanoic acid
1516:Papillary hidradenoma
1446:Mixed MĂĽllerian tumor
1397:Glassy-cell carcinoma
1186:Granulosa cell tumour
768:10.1515/CCLM.2007.120
253:
241:granulosa cell tumour
1750:Small-cell carcinoma
1387:Clear-cell carcinoma
1104:Mucinous cystadenoma
756:Clin. Chem. Lab. Med
1836:Endocrine neoplasia
1677:Embryonal carcinoma
1652:Spermatocytic tumor
1613:Sertoli cell tumour
1224:Embryonal carcinoma
1171:Sertoli cell tumour
1082:surface epithelial-
622:Am. J. Surg. Pathol
463:Gynecol. Endocrinol
403:Sertoli cell tumour
366:High magnification
184:, voice deepening,
129:Sertoli cell tumour
1790:Bowenoid papulosis
1618:Leydig cell tumour
1349:Endometrioid tumor
1166:Leydig cell tumour
1134:Endometrioid tumor
1109:Cystadenocarcinoma
990:External resources
598:10.1002/sono.12111
268:
260:Leydig cell tumour
254:Low magnification
197:precocious puberty
145:precocious puberty
114:testicular cancers
90:Leydig cell tumour
33:Leydig cell tumour
1808:
1807:
1714:
1713:
1710:
1709:
1579:urogenital system
1539:
1538:
1454:
1453:
1298:
1297:
1290:Adenomatoid tumor
1276:
1275:
1152:
1151:
1051:urogenital system
1013:
1012:
889:PathologyOutlines
815:10.1111/bju.12549
433:PathologyOutlines
333:Additional images
116:. It arises from
94:Leydig cell tumor
87:
86:
27:Medical condition
16:(Redirected from
1848:
1635:
1594:
1566:
1559:
1552:
1543:
1309:
1219:Nongerminomatous
1121:Krukenberg tumor
1089:
1073:
1064:
1040:
1033:
1026:
1017:
920:
908:
906:
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892:
880:
874:
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787:
747:
738:
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731:
726:
724:
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709:
703:
702:
692:
683:(5): 1897–1903.
660:
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616:
610:
609:
583:
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30:
21:
1856:
1855:
1851:
1850:
1849:
1847:
1846:
1845:
1811:
1810:
1809:
1804:
1785:Bowen's disease
1759:
1706:
1697:Choriocarcinoma
1663:
1624:
1600:gonadal stromal
1599:
1583:
1570:
1540:
1535:
1492:
1450:
1441:Uterine sarcoma
1429:
1420:Choriocarcinoma
1406:
1368:
1335:
1294:
1272:
1268:Meigs' syndrome
1254:
1248:Choriocarcinoma
1200:
1148:
1125:
1083:
1080:
1053:
1044:
1014:
1009:
1008:
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931:
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838:
796:
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749:
748:
741:
727:
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711:
710:
706:
677:Cancer Research
662:
661:
657:
628:(11): 1424–33.
618:
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613:
581:
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571:
541:
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536:
522:
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344:
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276:Reinke crystals
237:
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156:masculinization
141:
96:(US spelling),
77:
28:
23:
22:
15:
12:
11:
5:
1854:
1852:
1844:
1843:
1838:
1833:
1828:
1823:
1821:Ovarian cancer
1813:
1812:
1806:
1805:
1803:
1802:
1797:
1792:
1787:
1782:
1781:
1780:
1769:
1767:
1761:
1760:
1758:
1757:
1752:
1747:
1742:
1741:
1740:
1730:
1728:Adenocarcinoma
1724:
1722:
1716:
1715:
1712:
1711:
1708:
1707:
1705:
1704:
1699:
1694:
1689:
1687:Gonadoblastoma
1684:
1679:
1673:
1671:
1665:
1664:
1662:
1661:
1660:
1659:
1654:
1643:
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1389:
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1366:
1361:
1356:
1351:
1345:
1343:
1337:
1336:
1334:
1333:
1328:
1326:Leiomyosarcoma
1323:
1317:
1315:
1306:
1300:
1299:
1296:
1295:
1293:
1292:
1286:
1284:
1282:Fallopian tube
1278:
1277:
1274:
1273:
1271:
1270:
1264:
1262:
1256:
1255:
1253:
1252:
1251:
1250:
1245:
1236:
1234:Gonadoblastoma
1231:
1226:
1216:
1210:
1208:
1202:
1201:
1199:
1198:
1193:
1188:
1183:
1178:
1173:
1168:
1162:
1160:
1154:
1153:
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1149:
1147:
1146:
1144:Brenner tumour
1141:
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1123:
1118:
1117:
1116:
1106:
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1070:
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1049:of the female
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923:Classification
916:
915:External links
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875:
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789:
739:
730:|journal=
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611:
592:(3): 125–128.
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308:tumour markers
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173:defeminization
164:oligomenorrhea
150:Due to excess
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1488:Vaginal cysts
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1243:Struma ovarii
1240:
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1111:
1110:
1107:
1105:
1102:
1100:
1097:
1096:
1094:
1090:
1087:
1085:
1084:stromal tumor
1078:
1074:
1071:
1069:
1065:
1062:
1060:
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1052:
1048:
1041:
1036:
1034:
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1831:Rare cancers
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1577:of the male
1214:Dysgerminoma
1165:
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856:(2): 311–7.
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152:testosterone
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139:Presentation
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118:Leydig cells
101:
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1341:Endometrium
999:MedlinePlus
160:anovulation
38:Other names
1815:Categories
1331:Adenomyoma
1313:Myometrium
975:DiseasesDB
586:Sonography
414:References
368:micrograph
348:micrograph
325:: 10% are
284:calretinin
256:micrograph
201:oestrogens
168:amenorrhea
1773:Carcinoma
1630:Germ cell
1598:Sex cord–
1589:Testicles
1206:Germ cell
673:Activity"
327:malignant
319:prognosis
294:Treatment
272:histology
235:Diagnosis
193:androgens
182:hirsutism
108:group of
65:Specialty
1720:Prostate
1702:Embryoma
1692:Teratoma
1647:Seminoma
1511:Melanoma
1412:Placenta
1239:Teratoma
897:cite web
870:17284120
831:24924124
823:24180380
784:12883618
776:17484630
699:15753388
667:In vitro
650:25993642
642:12409718
606:79812660
491:42384623
483:18382911
441:cite web
392:See also
300:imatinib
70:Oncology
1434:General
1260:Fibroma
1191:Luteoma
1181:Thecoma
1068:Ovaries
969:D007984
803:BJU Int
671:In vivo
564:7676454
288:melan-A
245:thecoma
110:ovarian
92:, also
1575:Tumors
1460:Vagina
1374:Cervix
1304:Uterus
1059:Adnexa
1047:Tumors
1004:000409
959:: 8631
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323:benign
286:, and
76:
1765:Penis
1738:HGPIN
1498:Vulva
956:ICD-O
950:256.1
946:183.0
827:S2CID
780:S2CID
646:S2CID
602:S2CID
582:(PDF)
487:S2CID
258:of a
211:Cause
131:from
1092:CMS:
980:7445
964:MeSH
941:9-CM
903:link
866:PMID
819:PMID
772:PMID
734:help
695:PMID
669:and
638:PMID
560:PMID
529:help
479:PMID
447:link
317:The
231:).
180:and
178:acne
170:and
112:and
100:and
1506:SCC
1392:SCC
937:ICD
858:doi
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