304:
281:
178:
203:
555:
310:
209:
31:
57:
1540:
involves a decrease in expression of involucrin. This decrease could contribute to the altered desquamation process seen in the disease, since the clinical improvement associated with retinoid treatment is accompanied by increased expression of involucrin.
2372:"S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes"
1903:
Takahashi H, Hashimoto Y, Ishida-Yamamoto A, Iizuka H (September 2005). "Roxithromycin suppresses involucrin expression by modulation of activator protein-1 and nuclear factor-kappaB activities of keratinocytes".
2166:"Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity"
2199:
Volz A, Korge BP, Compton JG, Ziegler A, Steinert PM, Mischke D (October 1993). "Physical mapping of a functional cluster of epidermal differentiation genes on chromosome 1q21".
317:
216:
1347:
1238:
1109:
2053:"Biophysical characterization of involucrin reveals a molecule ideally suited to function as an intermolecular cross-bridge of the keratinocyte cornified envelope"
139:
773:
2633:"The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation"
754:
1493:
enzyme that makes it highly stable. Thus it provides structural support to the cell, thereby allowing the cell to resist invasion by micro-organisms.
2442:"Characterization of human involucrin promoter distal regulatory region transcriptional activator elements-a role for Sp1 and AP1 binding sites"
2012:"Presence in human epidermal cells of a soluble protein precursor of the cross-linked envelope: activation of the cross-linking by calcium ions"
2298:
Takahashi H, Kobayashi H, Matsuo S, Iizuka H (1995). "Repression of involucrin gene expression by transcriptional enhancer factor 1 (TEF-1)".
1864:"Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311"
1661:
1186:
1643:
2690:
54:
973:
303:
1975:
Eckert RL, Crish JF, Efimova T, Dashti SR, Deucher A, Bone F, Adhikary G, Huang G, Gopalakrishnan R, Balasubramanian S (July 2004).
980:
280:
1725:
2337:"Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope"
1940:
1630:
1609:
1626:
1367:
1258:
1129:
202:
177:
2230:"Analysis of the 5'-upstream promoter region of human involucrin gene: activation by 12-O-tetradecanoylphorbol-13-acetate"
1456:
1605:
119:
1576:
for the transglutaminase in the cross-linking reaction. The total size of the protein varies from 285 residues (in
1515:
316:
215:
309:
208:
2695:
1573:
818:
127:
1355:
1246:
1117:
2555:"Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes"
799:
1939:
Peña-Penabad C, de
Unamuno P, García Silva J, Ludeña MD, González Sarmiento R, Pérez-Arellano JL (1999).
2520:"The distal regulatory region of the human involucrin promoter is required for expression in epidermis"
1351:
1242:
1113:
2263:
Lopez-Bayghen E, Vega A, Cadena A, Granados SE, Jave LF, Gariglio P, Alvarez-Salas LM (January 1996).
1199:
191:
2485:"Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope"
106:
1537:
1418:
2584:
2323:
2039:
1704:
1550:
1486:
151:
2596:
Candi E, Oddi S, Terrinoni A, Paradisi A, Ranalli M, Finazzi-Agró A, Melino G (September 2001).
956:
935:
909:
888:
2598:"Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro"
2087:
2052:
2654:
2619:
2576:
2541:
2506:
2471:
2428:
2393:
2358:
2315:
2286:
2251:
2216:
2187:
2152:
2109:
2074:
2031:
1998:
1952:
1921:
1885:
1844:
1803:
1762:
1696:
1467:
1342:
1233:
1104:
99:
47:
2644:
2609:
2566:
2531:
2496:
2461:
2453:
2418:
2383:
2348:
2307:
2276:
2241:
2208:
2177:
2142:
2134:
2099:
2064:
2023:
1988:
1913:
1875:
1834:
1793:
1752:
1688:
1490:
1482:
1452:
1441:
1438:
396:
327:
271:
226:
2088:"The glutamine residues reactive in transglutaminase-catalyzed cross-linking of involucrin"
1334:
1225:
1096:
1798:
1781:
1757:
1741:"Consecutive actions of different gene-altering mechanisms in the evolution of involucrin"
1740:
1679:
Eckert RL, Green H (August 1986). "Structure and evolution of the human involucrin gene".
1518:
by suppressing involucrin, and this is associated with reduced cell proliferation without
1507:
371:
147:
554:
2466:
2441:
1565:
1470:
by transglutaminase thus helping in the formation of an insoluble envelope beneath the
1460:
2571:
2554:
2147:
2122:
2104:
2069:
688:
683:
678:
673:
668:
663:
647:
642:
637:
632:
627:
622:
606:
601:
596:
2684:
2027:
1993:
1976:
1692:
1471:
1448:
1191:
583:
2588:
2327:
2043:
1708:
1296:
1167:
1058:
2407:"Regulation of involucrin gene expression by calcium in normal human keratinocytes"
1917:
1780:
Djian P, Phillips M, Easley K, Huang E, Simon M, Rice RH, Green H (November 1993).
1534:, involucrin is markedly increased in inflammatory skin diseases such as psoriasis
1511:
1330:
1221:
1092:
389:
168:
2265:"Transcriptional analysis of the 5'-noncoding region of the human involucrin gene"
131:
2676:
2246:
2229:
1839:
1822:
1308:
1179:
1070:
155:
1666:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1648:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1504:
472:
1782:"The involucrin genes of the mouse and the rat: study of their shared repeats"
1557:
1553:
1531:
1398:
288:
185:
135:
2536:
2519:
2501:
2484:
2388:
2371:
2182:
2165:
2123:"Repeat arrays in cellular DNA related to the Epstein-Barr virus IR3 repeat"
2011:
1581:
1569:
1561:
1519:
1500:
1426:
718:
532:
410:
355:
342:
254:
241:
143:
2658:
2649:
2632:
2623:
2614:
2597:
2580:
2353:
2336:
2212:
2002:
1956:
1925:
1889:
1880:
1863:
1397:, involucrin contributes to the formation of a cell envelope that protects
2545:
2510:
2475:
2432:
2397:
2362:
2319:
2290:
2281:
2264:
2255:
2220:
2191:
2156:
2113:
2078:
1848:
1807:
1766:
1700:
1195:
1020:
1015:
2672:
1821:
Eckert RL, Yaffe MB, Crish JF, Murthy S, Rorke EA, Welter JF (May 1993).
1560:
residues followed by two extremely variable length segments that contain
1496:
1475:
1422:
1394:
1303:
1174:
1065:
1004:
863:
844:
2553:
Lee CH, Marekov LN, Kim S, Brahim JS, Park MH, Steinert PM (July 2000).
2138:
2035:
1941:"Altered expression of immunoreactive involucrin in lamellar ichthyosis"
30:
2311:
1463:
1444:
1410:
1383:
830:
785:
2457:
76:
1362:
1253:
1124:
988:
740:
2423:
2406:
703:
699:
2668:
1414:
1390:
1324:
1291:
1215:
1162:
1086:
1053:
123:
563:
1577:
2121:
Heller M, Flemington E, Kieff E, Deininger P (March 1985).
1386:
component of human skin and in humans is encoded by the
679:
isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
379:
2440:
Banks EB, Crish JF, Welter JF, Eckert RL (April 1998).
2370:
Robinson NA, Lapic S, Welter JF, Eckert RL (May 1997).
2667:
This article incorporates text from the public domain
2631:
Crish JF, Bone F, Banks EB, Eckert RL (January 2002).
2164:
Welter JF, Crish JF, Agarwal C, Eckert RL (May 1995).
1862:
Balasubramanian S, Zhu L, Eckert RL (November 2006).
1823:"Involucrin--structure and role in envelope assembly"
544:
1361:
1341:
1323:
1318:
1302:
1290:
1282:
1277:
1272:
1252:
1232:
1214:
1209:
1185:
1173:
1161:
1153:
1148:
1143:
1123:
1103:
1085:
1080:
1064:
1052:
1044:
1039:
1034:
949:
928:
902:
881:
1622:
1620:
1618:
1601:
1599:
1597:
1478:donor during assembly of the cornified envelope.
326:
225:
18:Protein-coding gene in the species Homo sapiens
2518:Crish JF, Zaim TM, Eckert RL (November 1998).
2405:Ng DC, Su MJ, Kim R, Bikle DD (January 1996).
1627:GRCm38: Ensembl release 89: ENSMUSG00000049128
8:
2051:Yaffe MB, Beegen H, Eckert RL (June 1992).
1606:GRCh38: Ensembl release 89: ENSG00000163207
1035:Involucrin of squamous epithelia N-terminus
1977:"Regulation of involucrin gene expression"
1437:Involucrin is a highly reactive, soluble,
1315:
1206:
1077:
714:
579:
483:transitional epithelium of urinary bladder
367:
266:
163:
65:
2648:
2613:
2570:
2535:
2500:
2465:
2422:
2387:
2352:
2280:
2245:
2181:
2146:
2103:
2068:
1992:
1879:
1838:
1797:
1756:
1510:agent, has been found to regulate normal
1466:, but ultimately becomes cross-linked to
2335:Steinert PM, Marekov LN (January 1997).
2234:The Journal of Investigative Dermatology
1981:The Journal of Investigative Dermatology
1827:The Journal of Investigative Dermatology
1720:
1718:
1530:As one of the precursor proteins of the
1593:
1572:residues in the tandem repeats are the
2228:Takahashi H, Iizuka H (January 1993).
1269:
1140:
1031:
597:protein-macromolecule adaptor activity
20:
2483:Marekov LN, Steinert PM (July 1998).
1799:10.1093/oxfordjournals.molbev.a040069
1758:10.1093/oxfordjournals.molbev.a040775
331:
292:
287:
230:
189:
184:
7:
2602:The Journal of Biological Chemistry
2524:The Journal of Biological Chemistry
2489:The Journal of Biological Chemistry
2376:The Journal of Biological Chemistry
2341:The Journal of Biological Chemistry
2300:Archives of Dermatological Research
2269:The Journal of Biological Chemistry
2170:The Journal of Biological Chemistry
2092:The Journal of Biological Chemistry
2057:The Journal of Biological Chemistry
1868:The Journal of Biological Chemistry
1409:This gene is mapped to 1q21, among
2086:Simon M, Green H (December 1988).
2010:Rice RH, Green H (November 1979).
1739:Green H, Djian P (November 1992).
1503:that has significant promise as a
946:
925:
899:
878:
854:
835:
809:
790:
764:
745:
549:
467:
405:
384:
14:
1906:Journal of Dermatological Science
1481:Involucrin is synthesised in the
1994:10.1111/j.0022-202X.2004.22723.x
553:
315:
308:
302:
279:
214:
207:
201:
176:
29:
1945:European Journal of Dermatology
1786:Molecular Biology and Evolution
1745:Molecular Biology and Evolution
2127:Molecular and Cellular Biology
1918:10.1016/j.jdermsci.2005.03.006
564:More reference expression data
533:More reference expression data
1:
2572:10.1016/S0014-5793(00)01806-8
2105:10.1016/S0021-9258(19)81327-3
2070:10.1016/S0021-9258(19)49829-3
1726:"Entrez Gene: IVL involucrin"
1457:stratified squamous epithelia
1319:Available protein structures:
1210:Available protein structures:
1081:Available protein structures:
300:
199:
2247:10.1111/1523-1747.ep12349867
2028:10.1016/0092-8674(79)90123-5
1840:10.1111/1523-1747.ep12472288
1693:10.1016/0092-8674(86)90884-6
684:keratinocyte differentiation
607:structural molecule activity
2691:Genes on human chromosome 1
511:granular layer of epidermis
2712:
2666:
1459:. It first appears in the
1662:"Mouse PubMed Reference:"
1644:"Human PubMed Reference:"
1549:Involucrin consists of a
1393:. In binding the protein
1314:
1205:
1076:
1019:
1014:
1010:
1003:
987:
974:Chr 1: 152.91 – 152.91 Mb
968:
953:
932:
921:
906:
885:
874:
861:
857:
842:
838:
829:
816:
812:
797:
793:
784:
771:
767:
752:
748:
739:
724:
717:
713:
697:
582:
578:
561:
552:
543:
530:
479:
470:
417:
408:
378:
370:
366:
349:
336:
299:
278:
269:
265:
248:
235:
198:
175:
166:
162:
117:
114:
104:
97:
92:
73:
68:
51:
46:
41:
37:
28:
23:
2537:10.1074/jbc.273.46.30460
2502:10.1074/jbc.273.28.17763
2389:10.1074/jbc.272.18.12035
2183:10.1074/jbc.270.21.12614
1485:and cross linked in the
2446:The Biochemical Journal
2411:Frontiers in Bioscience
1532:cornified cell envelope
981:Chr 3: 92.48 – 92.48 Mb
2650:10.1038/sj.onc.1205038
2615:10.1074/jbc.M010157200
2354:10.1074/jbc.272.3.2021
2213:10.1006/geno.1993.1430
1881:10.1074/jbc.M605368200
1580:) to 835 residues (in
2282:10.1074/jbc.271.1.512
1526:Clinical significance
669:peptide cross-linking
628:extracellular exosome
487:skin of external ear
333:3 F1|3 40.14 cM
294:Chromosome 3 (mouse)
192:Chromosome 1 (human)
69:List of PDB id codes
42:Available structures
2139:10.1128/mcb.5.3.457
1556:region of about 75
1538:Lamellar ichthyosis
421:gingival epithelium
2312:10.1007/BF01105799
1499:, a plant-derived
1487:stratum granulosum
819:ENSMUSG00000049128
657:Biological process
633:cornified envelope
616:Cellular component
590:Molecular function
2458:10.1042/bj3310061
1474:functioning as a
1468:membrane proteins
1377:
1376:
1373:
1372:
1368:structure summary
1273:Involucrin repeat
1268:
1267:
1264:
1263:
1259:structure summary
1144:Involucrin repeat
1139:
1138:
1135:
1134:
1130:structure summary
1030:
1029:
1026:
1025:
999:
998:
964:
963:
943:
942:
917:
916:
896:
895:
870:
869:
851:
850:
825:
824:
806:
805:
780:
779:
761:
760:
709:
708:
574:
573:
570:
569:
539:
538:
526:
525:
464:
463:
445:mucosa of pharynx
362:
361:
261:
260:
88:
87:
84:
83:
52:Ortholog search:
2703:
2662:
2652:
2627:
2617:
2608:(37): 35014–23.
2592:
2574:
2549:
2539:
2514:
2504:
2495:(28): 17763–70.
2479:
2469:
2436:
2426:
2401:
2391:
2382:(18): 12035–46.
2366:
2356:
2331:
2294:
2284:
2259:
2249:
2224:
2195:
2185:
2176:(21): 12614–22.
2160:
2150:
2117:
2107:
2082:
2072:
2047:
2006:
1996:
1961:
1960:
1936:
1930:
1929:
1900:
1894:
1893:
1883:
1874:(47): 36162–72.
1859:
1853:
1852:
1842:
1818:
1812:
1811:
1801:
1777:
1771:
1770:
1760:
1736:
1730:
1729:
1722:
1713:
1712:
1676:
1670:
1669:
1658:
1652:
1651:
1640:
1634:
1624:
1613:
1603:
1491:transglutaminase
1483:stratum spinosum
1439:transglutaminase
1316:
1270:
1207:
1141:
1078:
1032:
1012:
1011:
983:
976:
959:
947:
938:
926:
922:RefSeq (protein)
912:
900:
891:
879:
855:
836:
810:
791:
765:
746:
715:
664:response to UV-B
580:
566:
557:
550:
535:
475:
473:Top expressed in
468:
413:
411:Top expressed in
406:
385:
368:
358:
345:
334:
319:
312:
306:
295:
283:
267:
257:
244:
233:
218:
211:
205:
194:
180:
164:
158:
109:
102:
79:
66:
60:
39:
38:
33:
21:
2711:
2710:
2706:
2705:
2704:
2702:
2701:
2700:
2696:Protein domains
2681:
2680:
2679:
2665:
2630:
2595:
2552:
2530:(46): 30460–5.
2517:
2482:
2439:
2404:
2369:
2334:
2297:
2262:
2227:
2198:
2163:
2120:
2098:(34): 18093–8.
2085:
2063:(17): 12233–8.
2050:
2009:
1974:
1970:
1968:Further reading
1965:
1964:
1938:
1937:
1933:
1902:
1901:
1897:
1861:
1860:
1856:
1820:
1819:
1815:
1779:
1778:
1774:
1751:(6): 977–1017.
1738:
1737:
1733:
1724:
1723:
1716:
1678:
1677:
1673:
1660:
1659:
1655:
1642:
1641:
1637:
1625:
1616:
1604:
1595:
1590:
1547:
1528:
1516:differentiation
1508:chemopreventive
1472:plasma membrane
1435:
1413:I light chain,
1407:
1021:View/Edit Mouse
1016:View/Edit Human
979:
972:
969:Location (UCSC)
955:
934:
908:
887:
800:ENSG00000163207
693:
652:
611:
602:protein binding
562:
531:
522:
517:
513:
509:
505:
503:skin of abdomen
501:
497:
493:
489:
485:
471:
460:
455:
451:
447:
443:
439:
435:
431:
429:skin of abdomen
427:
423:
409:
353:
340:
332:
322:
321:
320:
313:
293:
270:Gene location (
252:
239:
231:
221:
220:
219:
212:
190:
167:Gene location (
156:IVL - orthologs
118:
105:
98:
75:
53:
19:
12:
11:
5:
2709:
2707:
2699:
2698:
2693:
2683:
2682:
2664:
2663:
2628:
2593:
2550:
2515:
2480:
2437:
2402:
2367:
2347:(3): 2021–30.
2332:
2295:
2260:
2225:
2196:
2161:
2118:
2083:
2048:
2007:
1971:
1969:
1966:
1963:
1962:
1951:(3): 197–201.
1931:
1895:
1854:
1813:
1792:(6): 1136–49.
1772:
1731:
1714:
1671:
1653:
1635:
1614:
1592:
1591:
1589:
1586:
1566:tandem repeats
1546:
1543:
1527:
1524:
1434:
1431:
1406:
1403:
1375:
1374:
1371:
1370:
1365:
1359:
1358:
1345:
1339:
1338:
1328:
1321:
1320:
1312:
1311:
1306:
1300:
1299:
1294:
1288:
1287:
1284:
1280:
1279:
1275:
1274:
1266:
1265:
1262:
1261:
1256:
1250:
1249:
1236:
1230:
1229:
1219:
1212:
1211:
1203:
1202:
1189:
1183:
1182:
1177:
1171:
1170:
1165:
1159:
1158:
1155:
1151:
1150:
1146:
1145:
1137:
1136:
1133:
1132:
1127:
1121:
1120:
1107:
1101:
1100:
1090:
1083:
1082:
1074:
1073:
1068:
1062:
1061:
1056:
1050:
1049:
1046:
1042:
1041:
1037:
1036:
1028:
1027:
1024:
1023:
1018:
1008:
1007:
1001:
1000:
997:
996:
994:
992:
985:
984:
977:
970:
966:
965:
962:
961:
951:
950:
944:
941:
940:
930:
929:
923:
919:
918:
915:
914:
904:
903:
897:
894:
893:
883:
882:
876:
872:
871:
868:
867:
859:
858:
852:
849:
848:
840:
839:
833:
827:
826:
823:
822:
814:
813:
807:
804:
803:
795:
794:
788:
782:
781:
778:
777:
769:
768:
762:
759:
758:
750:
749:
743:
737:
736:
731:
726:
722:
721:
711:
710:
707:
706:
695:
694:
692:
691:
686:
681:
676:
674:keratinization
671:
666:
660:
658:
654:
653:
651:
650:
645:
640:
635:
630:
625:
619:
617:
613:
612:
610:
609:
604:
599:
593:
591:
587:
586:
576:
575:
572:
571:
568:
567:
559:
558:
547:
541:
540:
537:
536:
528:
527:
524:
523:
521:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
480:
477:
476:
465:
462:
461:
459:
458:
454:
453:amniotic fluid
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
402:
401:
393:
382:
376:
375:
372:RNA expression
364:
363:
360:
359:
351:
347:
346:
338:
335:
330:
324:
323:
314:
307:
301:
297:
296:
291:
285:
284:
276:
275:
263:
262:
259:
258:
250:
246:
245:
237:
234:
229:
223:
222:
213:
206:
200:
196:
195:
188:
182:
181:
173:
172:
160:
159:
116:
112:
111:
103:
95:
94:
90:
89:
86:
85:
82:
81:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
2708:
2697:
2694:
2692:
2689:
2688:
2686:
2678:
2674:
2670:
2660:
2656:
2651:
2646:
2643:(5): 738–47.
2642:
2638:
2634:
2629:
2625:
2621:
2616:
2611:
2607:
2603:
2599:
2594:
2590:
2586:
2582:
2578:
2573:
2568:
2565:(3): 268–72.
2564:
2560:
2556:
2551:
2547:
2543:
2538:
2533:
2529:
2525:
2521:
2516:
2512:
2508:
2503:
2498:
2494:
2490:
2486:
2481:
2477:
2473:
2468:
2463:
2459:
2455:
2451:
2447:
2443:
2438:
2434:
2430:
2425:
2420:
2416:
2412:
2408:
2403:
2399:
2395:
2390:
2385:
2381:
2377:
2373:
2368:
2364:
2360:
2355:
2350:
2346:
2342:
2338:
2333:
2329:
2325:
2321:
2317:
2313:
2309:
2305:
2301:
2296:
2292:
2288:
2283:
2278:
2275:(1): 512–20.
2274:
2270:
2266:
2261:
2257:
2253:
2248:
2243:
2239:
2235:
2231:
2226:
2222:
2218:
2214:
2210:
2206:
2202:
2197:
2193:
2189:
2184:
2179:
2175:
2171:
2167:
2162:
2158:
2154:
2149:
2144:
2140:
2136:
2133:(3): 457–65.
2132:
2128:
2124:
2119:
2115:
2111:
2106:
2101:
2097:
2093:
2089:
2084:
2080:
2076:
2071:
2066:
2062:
2058:
2054:
2049:
2045:
2041:
2037:
2033:
2029:
2025:
2022:(3): 681–94.
2021:
2017:
2013:
2008:
2004:
2000:
1995:
1990:
1986:
1982:
1978:
1973:
1972:
1967:
1958:
1954:
1950:
1946:
1942:
1935:
1932:
1927:
1923:
1919:
1915:
1912:(3): 175–82.
1911:
1907:
1899:
1896:
1891:
1887:
1882:
1877:
1873:
1869:
1865:
1858:
1855:
1850:
1846:
1841:
1836:
1832:
1828:
1824:
1817:
1814:
1809:
1805:
1800:
1795:
1791:
1787:
1783:
1776:
1773:
1768:
1764:
1759:
1754:
1750:
1746:
1742:
1735:
1732:
1727:
1721:
1719:
1715:
1710:
1706:
1702:
1698:
1694:
1690:
1686:
1682:
1675:
1672:
1667:
1663:
1657:
1654:
1649:
1645:
1639:
1636:
1632:
1628:
1623:
1621:
1619:
1615:
1611:
1607:
1602:
1600:
1598:
1594:
1587:
1585:
1583:
1579:
1575:
1571:
1567:
1563:
1559:
1555:
1552:
1544:
1542:
1539:
1535:
1533:
1525:
1523:
1521:
1517:
1514:keratinocyte
1513:
1509:
1506:
1502:
1498:
1494:
1492:
1488:
1484:
1479:
1477:
1473:
1469:
1465:
1462:
1458:
1454:
1450:
1449:keratinocytes
1446:
1443:
1440:
1432:
1430:
1428:
1424:
1420:
1419:profillaggrin
1416:
1412:
1404:
1402:
1401:in the skin.
1400:
1396:
1392:
1389:
1385:
1381:
1369:
1366:
1364:
1360:
1357:
1353:
1349:
1346:
1344:
1340:
1336:
1332:
1329:
1326:
1322:
1317:
1313:
1310:
1307:
1305:
1301:
1298:
1295:
1293:
1289:
1285:
1281:
1276:
1271:
1260:
1257:
1255:
1251:
1248:
1244:
1240:
1237:
1235:
1231:
1227:
1223:
1220:
1217:
1213:
1208:
1204:
1201:
1197:
1193:
1190:
1188:
1184:
1181:
1178:
1176:
1172:
1169:
1166:
1164:
1160:
1156:
1152:
1147:
1142:
1131:
1128:
1126:
1122:
1119:
1115:
1111:
1108:
1106:
1102:
1098:
1094:
1091:
1088:
1084:
1079:
1075:
1072:
1069:
1067:
1063:
1060:
1057:
1055:
1051:
1047:
1043:
1038:
1033:
1022:
1017:
1013:
1009:
1006:
1002:
995:
993:
990:
986:
982:
978:
975:
971:
967:
960:
958:
952:
948:
945:
939:
937:
931:
927:
924:
920:
913:
911:
905:
901:
898:
892:
890:
884:
880:
877:
875:RefSeq (mRNA)
873:
866:
865:
860:
856:
853:
847:
846:
841:
837:
834:
832:
828:
821:
820:
815:
811:
808:
802:
801:
796:
792:
789:
787:
783:
776:
775:
770:
766:
763:
757:
756:
751:
747:
744:
742:
738:
735:
732:
730:
727:
723:
720:
716:
712:
705:
701:
696:
690:
689:cornification
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
661:
659:
656:
655:
649:
646:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
620:
618:
615:
614:
608:
605:
603:
600:
598:
595:
594:
592:
589:
588:
585:
584:Gene ontology
581:
577:
565:
560:
556:
551:
548:
546:
542:
534:
529:
518:
515:hair follicle
514:
510:
506:
502:
498:
494:
490:
486:
482:
481:
478:
474:
469:
466:
456:
452:
448:
444:
441:skin of thigh
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
403:
400:
398:
394:
392:
391:
387:
386:
383:
381:
377:
373:
369:
365:
357:
352:
348:
344:
339:
329:
325:
318:
311:
305:
298:
290:
286:
282:
277:
273:
268:
264:
256:
251:
247:
243:
238:
228:
224:
217:
210:
204:
197:
193:
187:
183:
179:
174:
170:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
113:
108:
101:
96:
91:
80:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
16:
2640:
2636:
2605:
2601:
2562:
2559:FEBS Letters
2558:
2527:
2523:
2492:
2488:
2449:
2445:
2424:10.2741/A101
2414:
2410:
2379:
2375:
2344:
2340:
2306:(8): 740–6.
2303:
2299:
2272:
2268:
2237:
2233:
2204:
2200:
2173:
2169:
2130:
2126:
2095:
2091:
2060:
2056:
2019:
2015:
1987:(1): 13–22.
1984:
1980:
1948:
1944:
1934:
1909:
1905:
1898:
1871:
1867:
1857:
1833:(5): 613–7.
1830:
1826:
1816:
1789:
1785:
1775:
1748:
1744:
1734:
1687:(4): 583–9.
1684:
1680:
1674:
1665:
1656:
1647:
1638:
1548:
1536:
1529:
1495:
1480:
1436:
1415:trichohyalin
1408:
1387:
1379:
1378:
1048:Involucrin_N
954:
933:
907:
886:
862:
843:
817:
798:
772:
753:
733:
728:
648:nuclear body
491:skin of back
395:
388:
253:152,911,886
240:152,908,546
115:External IDs
110:, involucrin
74:
15:
2452:(1): 61–8.
2240:(1): 10–5.
2207:(1): 92–9.
1505:skin cancer
1447:present in
1399:corneocytes
1286:Involucrin2
1278:Identifiers
1149:Identifiers
1040:Identifiers
457:human penis
433:skin of leg
425:oral cavity
354:92,481,042
341:92,478,209
93:Identifiers
2685:Categories
2417:: a16-24.
1633:, May 2017
1612:, May 2017
1588:References
1558:amino acid
1554:N-terminal
1455:and other
1380:Involucrin
1331:structures
1222:structures
1157:Involucrin
1093:structures
638:centrosome
495:belly cord
399:(ortholog)
136:HomoloGene
2677:IPR019571
1582:orangutan
1574:substrate
1570:glutamine
1562:glutamine
1551:conserved
1545:Structure
1520:apoptosis
1501:flavanoid
1453:epidermis
1442:substrate
1427:calcyclin
1411:calpactin
1309:IPR009733
1180:IPR000354
1071:IPR019571
957:NP_032438
936:NP_005538
910:NM_008412
889:NM_005547
719:Orthologs
623:cytoplasm
507:epidermis
144:GeneCards
2673:InterPro
2659:11850802
2637:Oncogene
2624:11443109
2589:12228606
2581:10908733
2328:23203303
2201:Genomics
2044:23066704
2003:15191537
1957:10210784
1926:16140218
1890:16982614
1709:39293076
1629:–
1608:–
1497:Apigenin
1476:glutamyl
1433:Function
1423:loricrin
1395:loricrin
1348:RCSB PDB
1304:InterPro
1239:RCSB PDB
1175:InterPro
1110:RCSB PDB
1066:InterPro
1005:Wikidata
698:Sources:
449:testicle
2546:9804813
2511:9651377
2476:9512462
2467:1219321
2433:9159190
2398:9115270
2363:8999895
2320:8554386
2291:8550612
2256:8380829
2221:8276421
2192:7759510
2157:2985954
2114:2461365
2079:1601889
1849:8098344
1808:8277848
1767:1359382
1701:2873896
1631:Ensembl
1610:Ensembl
1489:by the
1464:cytosol
1445:protein
1384:protein
1297:PF06994
1168:PF00904
1059:PF10583
831:UniProt
786:Ensembl
725:Species
704:QuickGO
643:cytosol
519:condyle
374:pattern
100:Aliases
2657:
2622:
2587:
2579:
2544:
2509:
2474:
2464:
2431:
2396:
2361:
2326:
2318:
2289:
2254:
2219:
2190:
2155:
2148:366737
2145:
2112:
2077:
2042:
2034:
2001:
1955:
1924:
1888:
1847:
1806:
1765:
1707:
1699:
1568:. The
1564:-rich
1425:, and
1363:PDBsum
1337:
1327:
1283:Symbol
1254:PDBsum
1228:
1218:
1200:SUPFAM
1154:Symbol
1125:PDBsum
1099:
1089:
1045:Symbol
991:search
989:PubMed
864:P48997
845:P07476
741:Entrez
545:BioGPS
232:1q21.3
140:136793
124:147360
2585:S2CID
2324:S2CID
2040:S2CID
2036:42494
1705:S2CID
1512:human
1382:is a
1196:SCOPe
1187:SCOP2
774:16447
734:Mouse
729:Human
700:Amigo
437:vulva
397:Mouse
390:Human
337:Start
272:Mouse
236:Start
169:Human
132:96626
2671:and
2669:Pfam
2655:PMID
2620:PMID
2577:PMID
2542:PMID
2507:PMID
2472:PMID
2429:PMID
2394:PMID
2359:PMID
2316:PMID
2287:PMID
2252:PMID
2217:PMID
2188:PMID
2153:PMID
2110:PMID
2075:PMID
2032:PMID
2016:Cell
1999:PMID
1953:PMID
1922:PMID
1886:PMID
1845:PMID
1804:PMID
1763:PMID
1697:PMID
1681:Cell
1461:cell
1405:Gene
1391:gene
1356:PDBj
1352:PDBe
1335:ECOD
1325:Pfam
1292:Pfam
1247:PDBj
1243:PDBe
1226:ECOD
1216:Pfam
1192:1eu0
1163:Pfam
1118:PDBj
1114:PDBe
1097:ECOD
1087:Pfam
1054:Pfam
755:3713
380:Bgee
328:Band
289:Chr.
227:Band
186:Chr.
120:OMIM
77:1EU0
58:RCSB
55:PDBe
2645:doi
2610:doi
2606:276
2567:doi
2563:477
2532:doi
2528:273
2497:doi
2493:273
2462:PMC
2454:doi
2450:331
2419:doi
2384:doi
2380:272
2349:doi
2345:272
2308:doi
2304:287
2277:doi
2273:271
2242:doi
2238:100
2209:doi
2178:doi
2174:270
2143:PMC
2135:doi
2100:doi
2096:263
2065:doi
2061:267
2024:doi
1989:doi
1985:123
1914:doi
1876:doi
1872:281
1835:doi
1831:100
1794:doi
1753:doi
1689:doi
1584:).
1578:dog
1451:of
1388:IVL
1343:PDB
1234:PDB
1105:PDB
499:lip
350:End
249:End
152:OMA
148:IVL
128:MGI
107:IVL
48:PDB
24:IVL
2687::
2675::
2653:.
2641:21
2639:.
2635:.
2618:.
2604:.
2600:.
2583:.
2575:.
2561:.
2557:.
2540:.
2526:.
2522:.
2505:.
2491:.
2487:.
2470:.
2460:.
2448:.
2444:.
2427:.
2413:.
2409:.
2392:.
2378:.
2374:.
2357:.
2343:.
2339:.
2322:.
2314:.
2302:.
2285:.
2271:.
2267:.
2250:.
2236:.
2232:.
2215:.
2205:18
2203:.
2186:.
2172:.
2168:.
2151:.
2141:.
2129:.
2125:.
2108:.
2094:.
2090:.
2073:.
2059:.
2055:.
2038:.
2030:.
2020:18
2018:.
2014:.
1997:.
1983:.
1979:.
1947:.
1943:.
1920:.
1910:39
1908:.
1884:.
1870:.
1866:.
1843:.
1829:.
1825:.
1802:.
1790:10
1788:.
1784:.
1761:.
1747:.
1743:.
1717:^
1703:.
1695:.
1685:46
1683:.
1664:.
1646:.
1617:^
1596:^
1522:.
1429:.
1421:,
1417:,
1354:;
1350:;
1333:/
1245:;
1241:;
1224:/
1198:/
1194:/
1116:;
1112:;
1095:/
702:/
356:bp
343:bp
255:bp
242:bp
150:;
146::
142:;
138::
134:;
130::
126:;
122::
2661:.
2647::
2626:.
2612::
2591:.
2569::
2548:.
2534::
2513:.
2499::
2478:.
2456::
2435:.
2421::
2415:1
2400:.
2386::
2365:.
2351::
2330:.
2310::
2293:.
2279::
2258:.
2244::
2223:.
2211::
2194:.
2180::
2159:.
2137::
2131:5
2116:.
2102::
2081:.
2067::
2046:.
2026::
2005:.
1991::
1959:.
1949:9
1928:.
1916::
1892:.
1878::
1851:.
1837::
1810:.
1796::
1769:.
1755::
1749:9
1728:.
1711:.
1691::
1668:.
1650:.
274:)
171:)
154::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
