1706:
357:
334:
231:
256:
3518:
3548:
608:
363:
262:
3533:
40:
1626:
in a cohort of 17 healthy human volunteers. This experimental vaccine was well-tolerated, and those who received the adjuvanted vaccine had stronger anti-HCV immune responses (enhanced magnitude, breadth and proliferative capacity of anti-HCV-specific T-cells) compared with volunteers who received
66:
1713:
CD74 receptor is expressed on the surface of different cell types. Interaction between MIF cytokine and its cell membrane receptor CD74 activates pro-survival and proliferative pathways that protect against injury and promote healing in different parts of the body.
2490:"The dexamethasone-induced inhibition of proliferation, migration, and invasion in glioma cell lines is antagonized by macrophage migration inhibitory factor (MIF) and can be enhanced by specific MIF inhibitors"
1585:
interacts with MHC II, releasing CLIP and allowing other peptides to bind. In some cases, CLIP dissociates without any further molecular interactions, but in other cases the binding to the MHC is more stable.
1556:
The invariant chain also facilitates the export of MHC class II from the RER in a vesicle. The signal for endosomal targeting resides in the cytoplasmic tail of the invariant chain. This fuses with a late
3333:
Naujokas MF, Morin M, Anderson MS, Peterson M, Miller J (July 1993). "The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44".
4449:
2396:
Wang F, Shen X, Guo X, Peng Y, Liu Y, Xu S, Yang J (February 2010). "Spinal macrophage migration inhibitory factor contributes to the pathogenesis of inflammatory hyperalgesia in rats".
2710:
Riberdy JM, Newcomb JR, Surman MJ, Barbosa JA, Cresswell P (December 1992). "HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides".
3288:
Brown JH, Jardetzky TS, Gorga JC, Stern LJ, Urban RG, Strominger JL, Wiley DC (July 1993). "Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1".
3588:
3517:
370:
269:
4439:
2967:"Structure of the human Ia-associated invariant (gamma)-chain gene: identification of 5' sequences shared with major histocompatibility complex class II genes"
1561:
containing the endocytosed antigen proteins (from the exogenous pathway). Binding to Ii ensures that no antigen peptides from the endogenous pathway meant for
2320:"Targeting Parasite-Produced Macrophage Migration Inhibitory Factor as an Antivirulence Strategy With Antibiotic-Antibody Combination to Reduce Tissue Damage"
1553:(RER) binds a segment of the invariant chain (Ii; a trimer) in order to shape the peptide-binding groove and prevent the formation of a closed conformation.
4419:
3547:
2275:
Baerlecken NT, Nothdorft S, Stummvoll GH, Sieper J, Rudwaleit M, Reuter S, et al. (June 2014). "Autoantibodies against CD74 in spondyloarthritis".
1176:
192:
5281:
3605:
3581:
2641:
Jones PP, Murphy DB, Hewgill D, McDevitt HO (January 1979). "Detection of a common polypeptide chain in I--A and I--E sub-region immunoprecipitates".
1593:
on the cell surface. Without CLIP, MHC class II aggregates disassemble and/or denature in the endosomes, and proper antigen presentation is impaired.
1157:
1670:
2249:
5012:
5000:
4778:
3047:
Claesson L, Peterson PA (June 1983). "Association of human gamma chain with class II transplantation antigens during intracellular transport".
1694:
1534:
5064:
5059:
5005:
4785:
3566:
3497:
3200:
Ghosh P, Amaya M, Mellins E, Wiley DC (November 1995). "The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3".
3120:
2083:
1833:
5618:
5613:
4518:
4444:
3574:
1815:
1674:
3078:"The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity"
2756:
356:
63:
5547:
5542:
5537:
5532:
4459:
1853:"cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure"
1416:
3457:
2887:"Four Ia invariant chain forms derive from a single gene by alternate splicing and alternate initiation of transcription/translation"
2801:"Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens"
1423:
333:
5512:
3532:
3163:
Machamer CE, Cresswell P (December 1982). "Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens".
1705:
2928:
Genuardi M, Saunders GF (1988). "Localization of the HLA class II-associated invariant chain gene to human chromosome band 5q32".
4748:
1735:
1574:
1546:
5316:
4810:
4496:
1802:
1781:
4955:
4491:
1798:
3440:
1581:
remaining bound to the groove of MHC class II molecules. The rest of the Ii is degraded. CLIP blocks peptide-binding until
255:
230:
5452:
4924:
4919:
4864:
4598:
4047:
3463:
1777:
5146:
4869:
3018:
Koch N, HΓ€mmerling GJ (October 1985). "Ia-associated invariant chain is fatty acylated before addition of sialic acid".
172:
4464:
1690:
2441:"The crystal structures of macrophage migration inhibitory factor from Plasmodium falciparum and Plasmodium berghei"
369:
268:
5176:
3601:
1747:
4042:
3490:
362:
261:
5226:
4121:
3434:
1221:
180:
5190:
1666:
1202:
1037:
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
2156:
Vogt AB, Kropshofer H (April 1999). "HLA-DM - an endosomal and lysosomal chaperone for the immune system".
5623:
4533:
4528:
4523:
4513:
3820:
3748:
1678:
3450:
3877:
3795:
1912:"Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens"
1550:
1530:
5114:
4827:
3483:
3383:
3297:
3209:
2978:
2719:
2193:"MHC class II invariant chain-adjuvanted viral vectored vaccines enhances T cell responses in humans"
1864:
1590:
1518:
244:
2439:
Dobson SE, Augustijn KD, Brannigan JA, Schnick C, Janse CJ, Dodson EJ, et al. (December 2009).
159:
5141:
4960:
3469:
2109:"The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway"
1623:
1395:
1374:
1370:
1362:
1358:
1328:
1307:
1303:
1299:
1295:
3372:"Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization"
1722:
The invariant chain was first described by
Patricia P. Jones, Donal B. Murphy, Derek Hewgill, and
4548:
4282:
3430:
3358:
3321:
3233:
3188:
3151:
2953:
2873:
2787:
2743:
2421:
2300:
2230:
1662:
1611:
204:
1399:
1366:
1332:
1291:
1565:
molecules accidentally bind to the groove of MHC class II molecules. The Ii is then cleaved by
3411:
3350:
3313:
3276:
3225:
3180:
3143:
3107:
3064:
3035:
3006:
2945:
2916:
2865:
2830:
2779:
2757:"MHC class II-associated invariant chain contains a sorting signal for endosomal compartments"
2735:
2698:
2658:
2623:
2592:"Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair"
2572:
2521:
2470:
2413:
2378:
2351:
2292:
2222:
2173:
2138:
2089:
2079:
2053:
2022:"Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair"
2002:
1941:
1892:
1615:
152:
56:
3247:"Mapping functional regions in the lumenal domain of the class II-associated invariant chain"
2191:
Esposito I, Cicconi P, D'Alise AM, Brown A, Esposito M, Swadling L, et al. (June 2020).
5321:
5054:
4975:
4538:
3731:
3657:
3444:
3401:
3391:
3342:
3305:
3266:
3258:
3217:
3172:
3135:
3097:
3089:
3056:
3027:
2996:
2986:
2937:
2906:
2898:
2855:
2820:
2812:
2771:
2727:
2690:
2650:
2613:
2603:
2562:
2552:
2511:
2501:
2460:
2452:
2405:
2341:
2331:
2284:
2212:
2204:
2165:
2128:
2120:
2043:
2033:
1994:
1931:
1923:
1882:
1872:
1631:
449:
380:
324:
279:
5381:
3917:
3912:
3835:
3526:: CRYSTAL STRUCTURE OF MHC CLASS II ASSOCIATED P41 II FRAGMENT IN COMPLEX WITH CATHEPSIN L
2318:
Ghosh S, Padalia J, Ngobeni R, Abendroth J, Farr L, Shirley DA, et al. (March 2020).
607:
424:
200:
3387:
3301:
3213:
2982:
2723:
1998:
1868:
5166:
4588:
4099:
3902:
3271:
3246:
3093:
2911:
2886:
2825:
2800:
2618:
2591:
2567:
2540:
2539:
Verjans E, Noetzel E, Bektas N, SchΓΌtz AK, Lue H, Lennartz B, et al. (July 2009).
2516:
2489:
2465:
2440:
2346:
2319:
2217:
2192:
2133:
2108:
2048:
2021:
1654:
1634:, if this enhancing effect can be demonstrated to apply to the appropriate antigen(s).
1578:
3102:
3077:
3001:
2966:
2369:
Shan ZX, Lin QX, Deng CY, Tan HH, Kuang SJ, Xiao DZ, et al. (December 2009). "".
2169:
1936:
1911:
1887:
1852:
1091:
1086:
1081:
1076:
1071:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1001:
996:
991:
986:
981:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
39:
5607:
5136:
4593:
3684:
3406:
3371:
3346:
3139:
2775:
2654:
2234:
1723:
1526:
942:
negative regulation of DNA damage response, signal transduction by p53 class mediator
636:
3362:
3192:
2791:
2425:
2304:
2288:
1529:
responses. The cell surface form of the invariant chain is known as CD74. CD74 is a
5492:
4800:
4790:
4321:
4287:
3325:
3237:
3155:
2957:
2877:
2747:
1985:
Cresswell P (1994). "Assembly, transport, and function of MHC class II molecules".
1607:
1570:
1522:
442:
221:
3121:"Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens"
2541:"Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer"
184:
2208:
912:
antigen processing and presentation of exogenous peptide antigen via MHC class II
208:
5502:
5151:
4929:
4904:
4603:
4225:
4151:
3625:
3176:
2860:
2843:
2250:"Adjuvanted viral-vectored vaccine promising against hepatitis C in early trial"
1838:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1820:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1752:
1643:
1566:
1562:
3376:
Proceedings of the
National Academy of Sciences of the United States of America
2971:
Proceedings of the
National Academy of Sciences of the United States of America
2694:
2409:
1857:
Proceedings of the
National Academy of Sciences of the United States of America
525:
17:
5432:
5156:
4837:
4578:
4454:
4087:
4082:
4077:
3932:
3716:
2124:
1658:
341:
238:
188:
2608:
2093:
2038:
1927:
5271:
5266:
5261:
5251:
5246:
5241:
5236:
3396:
2991:
2965:
O'Sullivan DM, Larhammar D, Wilson MC, Peterson PA, Quaranta V (June 1986).
2681:
Stove V, Verhasselt B (January 2006). "Modelling thymic HIV-1 Nef effects".
2557:
2506:
2336:
1877:
1642:
Found on a number of cancer cell types. Possible cancer therapy target. See
1121:
585:
463:
408:
395:
307:
294:
196:
2702:
2627:
2576:
2525:
2488:
Piette C, Deprez M, Roger T, NoΓ«l A, Foidart JM, Munaut C (November 2009).
2474:
2417:
2382:
2355:
2296:
2226:
2177:
2142:
2057:
3415:
3354:
3317:
3280:
3262:
3229:
3184:
3147:
3111:
3068:
3039:
3010:
2949:
2920:
2902:
2869:
2834:
2816:
2783:
2739:
2006:
1945:
1896:
1630:
The Ii molecule might also prove to be useful as an adjuvant for a future
1463:
1458:
5577:
5477:
5291:
5276:
4479:
4474:
4382:
4072:
2662:
1959:
1726:
at
Stanford. The nomenclature "Ii" comes from an Ix-based naming system (
1619:
1558:
1447:
1266:
1247:
907:
positive regulation of dendritic cell antigen processing and presentation
3060:
3031:
5527:
5522:
5517:
5417:
5231:
5221:
5048:
5027:
5022:
4990:
4795:
4715:
4710:
4705:
4700:
4695:
4613:
4306:
4146:
4141:
4136:
4131:
4126:
3597:
2941:
2844:"The invariant chain is a phosphorylated subunit of class II molecules"
1514:
1495:
1233:
1188:
2371:
Nan Fang Yi Ke da Xue Xue Bao = Journal of
Southern Medical University
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
5467:
5427:
5412:
5396:
5391:
5371:
5366:
5301:
5109:
5079:
5043:
5034:
4847:
4815:
4679:
4674:
4644:
4623:
4583:
4543:
4409:
4387:
4346:
4270:
4265:
4260:
4255:
4250:
4245:
4114:
4109:
4104:
4052:
4037:
3907:
3897:
3860:
3855:
3773:
3768:
3309:
3221:
3119:
Kvist S, Wiman K, Claesson L, Peterson PA, Dobberstein B (May 1982).
2731:
1582:
1431:
1143:
2456:
806:
integral component of lumenal side of endoplasmic reticulum membrane
3370:
Roche PA, Teletski CL, Stang E, Bakke O, Long EO (September 1993).
5592:
5567:
5487:
5482:
5472:
5462:
5447:
5442:
5437:
5422:
5376:
5361:
5326:
5311:
5306:
5296:
5216:
5211:
5206:
5185:
5181:
5171:
5084:
4985:
4980:
4939:
4889:
4884:
4879:
4874:
4859:
4852:
4832:
4820:
4763:
4758:
4753:
4743:
4738:
4731:
4669:
4659:
4654:
4649:
4639:
4618:
4608:
4573:
4568:
4563:
4558:
4553:
4508:
4503:
4469:
4434:
4429:
4424:
4414:
4402:
4397:
4377:
4372:
4367:
4362:
4316:
4208:
4203:
4022:
4006:
3999:
3994:
3989:
3984:
3979:
3974:
3949:
3927:
3922:
3815:
3741:
3736:
3726:
3556:: NMR structure of P41icf, a potent inhibitor of human cathepsin L
1704:
962:
positive regulation of chemokine (C-X-C motif) ligand 2 production
1106:
1102:
5587:
5582:
5572:
5562:
5557:
5552:
5507:
5497:
5457:
5386:
5356:
5351:
5346:
5341:
5336:
5331:
5286:
5256:
5161:
5129:
5124:
5104:
5094:
5089:
5074:
5069:
4970:
4965:
4934:
4914:
4909:
4899:
4894:
4773:
4726:
4686:
4341:
4336:
4331:
4326:
4311:
4302:
4297:
4292:
4277:
4235:
4230:
4220:
4215:
4198:
4193:
4183:
4178:
4173:
4168:
4163:
4158:
4094:
4067:
4062:
4057:
4032:
4027:
3964:
3959:
3954:
3944:
3939:
3892:
3887:
3882:
3872:
3867:
3850:
3845:
3840:
3830:
3825:
3810:
3805:
3800:
3790:
3785:
3780:
3763:
3758:
3753:
3704:
3672:
3667:
3662:
3645:
3640:
3635:
3630:
1502:
176:
3570:
3479:
5099:
3711:
3699:
3694:
3689:
3679:
3652:
3620:
3475:
1851:
Claesson L, Larhammar D, Rask L, Peterson PA (December 1983).
616:
1057:
positive regulation of I-kappaB kinase/NF-kappaB signaling
1042:
positive regulation of cytokine-mediated signaling pathway
982:
antigen processing and presentation of endogenous antigen
2074:
Owen JA, Punt J, Stranford SA, Jones PP, Kuby J (2013).
967:
macrophage migration inhibitory factor signaling pathway
927:
positive regulation of peptidyl-tyrosine phosphorylation
660:
MHC class II protein binding, via antigen binding groove
432:
1910:
Kudo J, Chao LY, Narni F, Saunders GF (December 1985).
1709:
Role of CD74 receptor in tissue injury and wound repair
786:
macrophage migration inhibitory factor receptor complex
932:
negative regulation of mature B cell apoptotic process
163:, DHLAG, HLADG, II, Ia-GAMMA, CD74 molecule, p33, CLIP
1007:
positive regulation of macrophage cytokine production
597:
3245:
Bijlmakers MJ, Benaroch P, Ploegh HL (August 1994).
5405:
5199:
4948:
4632:
4355:
4015:
3613:
2885:O'Sullivan DM, Noonan D, Quaranta V (August 1987).
1521:. It is involved in the formation and transport of
1476:
HLA class II histocompatibility antigen gamma chain
1388:
1351:
1321:
1284:
1072:
positive regulation of transcription, DNA-templated
1794:
1792:
1790:
1773:
1771:
1769:
1589:The stable MHC class II + antigen complex is then
2799:Marks MS, Blum JS, Cresswell P (September 1990).
1077:positive regulation of viral entry into host cell
379:
278:
1657:against CD74 have been identified as promising
1067:positive regulation of monocyte differentiation
1022:positive regulation of fibroblast proliferation
2107:Schulze MS, Wucherpfennig KW (February 2012).
1799:GRCm38: Ensembl release 89: ENSMUSG00000024610
1047:positive regulation of protein phosphorylation
892:chaperone cofactor-dependent protein refolding
670:macrophage migration inhibitory factor binding
3582:
3491:
1002:negative regulation of T cell differentiation
902:positive regulation of type 2 immune response
872:positive regulation of T cell differentiation
8:
3541:: HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN
2069:
2067:
1032:positive regulation of ERK1 and ERK2 cascade
957:positive regulation of neutrophil chemotaxis
1778:GRCh38: Ensembl release 89: ENSG00000019582
1012:positive regulation of B cell proliferation
3589:
3575:
3567:
3498:
3484:
3476:
1480:HLA-DR antigens-associated invariant chain
1117:
841:clathrin-coated endocytic vesicle membrane
632:
420:
319:
216:
74:
3606:list of human clusters of differentiation
3433:at the U.S. National Library of Medicine
3405:
3395:
3270:
3101:
3076:Strubin M, Mach B, Long EO (April 1984).
3000:
2990:
2910:
2859:
2824:
2617:
2607:
2566:
2556:
2515:
2505:
2464:
2345:
2335:
2216:
2132:
2047:
2037:
1935:
1886:
1876:
1627:the vaccine that lacked the Ii adjuvant.
2755:Bakke O, Dobberstein B (November 1990).
2078:(7th ed.). New York: W.H. Freeman.
1697:(MIF) to mediate some of its functions.
1671:non-radiographic axial spondyloarthritis
1577:), leaving only a small fragment called
1525:peptide complexes for the generation of
997:negative regulation of peptide secretion
877:negative regulation of apoptotic process
3513:
1765:
1734:mmune) that predates the naming of the
947:immunoglobulin mediated immune response
27:Mammalian protein found in Homo sapiens
1695:Macrophage migration inhibitory factor
1535:macrophage migration inhibitory factor
1052:positive regulation of kinase activity
761:ER to Golgi transport vesicle membrane
29:
2842:Spiro RC, Quaranta V (October 1989).
384:
345:
340:
283:
242:
237:
7:
3251:The Journal of Experimental Medicine
2891:The Journal of Experimental Medicine
1675:radiographic axial spondyloarthritis
680:MHC class II protein complex binding
2494:The Journal of Biological Chemistry
1999:10.1146/annurev.iy.12.040194.001355
1618:(HCV) genomeβhas been tested as an
1092:protein-containing complex assembly
1062:positive regulation of MAPK cascade
937:regulation of macrophage activation
922:antigen processing and presentation
3094:10.1002/j.1460-2075.1984.tb01898.x
2590:Farr L, Ghosh S, Moonah S (2020).
2324:The Journal of Infectious Diseases
2020:Farr L, Ghosh S, Moonah S (2020).
1385:
1348:
1318:
1281:
1257:
1238:
1212:
1193:
1167:
1148:
972:prostaglandin biosynthetic process
801:intracellular anatomical structure
675:protein folding chaperone activity
602:
520:
458:
437:
25:
1960:"UniProtKB - P04233 (HG2A_HUMAN)"
1498:that in humans is encoded by the
3546:
3531:
3516:
2277:Annals of the Rheumatic Diseases
1736:Major Histocompatibility Complex
1632:vaccine for the SARS-CoV-2 virus
1575:cortical thymic epithelial cells
1017:negative thymic T cell selection
887:positive thymic T cell selection
851:external side of plasma membrane
606:
368:
361:
355:
332:
267:
260:
254:
229:
38:
2289:10.1136/annrheumdis-2012-202208
1517:which plays a critical role in
1027:intracellular protein transport
2197:Science Translational Medicine
2158:Trends in Biochemical Sciences
1966:. The UniProt Consortium. 2020
1661:in the early diagnosis of the
816:endoplasmic reticulum membrane
756:integral component of membrane
617:More reference expression data
586:More reference expression data
1:
2170:10.1016/s0968-0004(99)01364-x
2113:Current Opinion in Immunology
1606:The Ii moleculeβfused with a
1082:protein heterotetramerization
977:cell population proliferation
650:nitric-oxide synthase binding
353:
252:
3347:10.1016/0092-8674(93)90417-O
3140:10.1016/0092-8674(82)90090-3
2776:10.1016/0092-8674(90)90137-4
2655:10.1016/0161-5890(79)90027-0
2209:10.1126/scitranslmed.aaz7715
1755:the first Mab to target CD74
781:trans-Golgi network membrane
731:MHC class II protein complex
695:MHC class II protein binding
5619:Clusters of differentiation
5614:Genes on human chromosome 5
3602:clusters of differentiation
3177:10.4049/jimmunol.129.6.2564
2861:10.4049/jimmunol.143.8.2589
2805:The Journal of Cell Biology
1987:Annual Review of Immunology
1551:rough endoplasmic reticulum
5640:
3468:gene details page in the
2695:10.2174/157016206775197583
2410:10.1016/j.pain.2009.11.011
2248:Larkin M (June 24, 2020).
1748:Cluster of differentiation
751:transport vesicle membrane
746:endocytic vesicle membrane
665:cytokine receptor activity
3511:
3451:School of Crystallography
2125:10.1016/j.coi.2011.11.004
1964:The UniProt Knowledgebase
1834:"Mouse PubMed Reference:"
1816:"Human PubMed Reference:"
1494:ifferentiation 74), is a
1462:
1457:
1453:
1446:
1430:
1411:
1392:
1355:
1344:
1325:
1288:
1277:
1264:
1260:
1245:
1241:
1232:
1219:
1215:
1200:
1196:
1187:
1174:
1170:
1155:
1151:
1142:
1127:
1120:
1116:
1100:
655:identical protein binding
635:
631:
614:
605:
596:
583:
532:
523:
470:
461:
431:
423:
419:
402:
389:
352:
331:
322:
318:
301:
288:
251:
228:
219:
215:
170:
167:
157:
150:
145:
82:
77:
60:
55:
50:
46:
37:
32:
3435:Medical Subject Headings
2609:10.3389/fimmu.2020.01273
2039:10.3389/fimmu.2020.01273
1549:class II protein in the
1424:Chr 18: 60.94 β 60.95 Mb
1417:Chr 5: 150.4 β 150.41 Mb
917:adaptive immune response
3397:10.1073/pnas.90.18.8581
2992:10.1073/pnas.83.12.4484
2596:Frontiers in Immunology
2558:10.1186/1471-2407-9-230
2507:10.1074/jbc.M109.014589
2026:Frontiers in Immunology
1878:10.1073/pnas.80.24.7395
1667:axial spondyloarthritis
1650:Axial spondyloarthritis
502:upper lobe of left lung
2256:. GI Health Foundation
1928:10.1093/nar/13.24.8827
1916:Nucleic Acids Research
1710:
1679:Ankylosing spondylitis
386:18 E1|18 34.41 cM
3263:10.1084/jem.180.2.623
3165:Journal of Immunology
2903:10.1084/jem.166.2.444
2848:Journal of Immunology
2817:10.1083/jcb.111.3.839
2337:10.1093/infdis/jiz579
1708:
1597:Clinical significance
1531:cell surface receptor
1087:protein trimerization
987:immune system process
811:endoplasmic reticulum
726:extracellular exosome
347:Chromosome 18 (mouse)
3462:genome location and
2683:Current HIV Research
2643:Molecular Immunology
2377:(12): 2383β6, 2390.
1519:antigen presentation
705:CD4 receptor binding
685:amyloid-beta binding
572:white adipose tissue
245:Chromosome 5 (human)
78:List of PDB id codes
51:Available structures
3470:UCSC Genome Browser
3453:The Invariant Chain
3447:(student generated)
3431:CD74+protein,+human
3388:1993PNAS...90.8581R
3302:1993Natur.364...33B
3214:1995Natur.378..457G
3061:10.1021/bi00282a026
3032:10.1021/bi00343a023
2983:1986PNAS...83.4484O
2724:1992Natur.360..474R
2500:(47): 32483β32492.
2254:Reuters Health News
1869:1983PNAS...80.7395C
952:leukocyte migration
882:signal transduction
766:multivesicular body
2942:10.1007/BF00372530
1711:
1701:Recovery functions
1693:with the cytokine
1663:autoimmune disease
1222:ENSMUSG00000024610
860:Biological process
736:lysosomal membrane
714:Cellular component
643:Molecular function
506:lower lobe of lung
5601:
5600:
3564:
3563:
3382:(18): 8581β8585.
3208:(6556): 457β462.
3055:(13): 3206β3213.
3026:(22): 6185β6190.
2977:(12): 4484β4488.
2718:(6403): 474β477.
2451:(12): 2578β2591.
2203:(548): eaaz7715.
2085:978-1-4641-1991-0
1922:(24): 8827β8841.
1863:(24): 7395β7399.
1616:Hepatitis C virus
1533:for the cytokine
1473:
1472:
1469:
1468:
1442:
1441:
1407:
1406:
1382:
1381:
1340:
1339:
1315:
1314:
1273:
1272:
1254:
1253:
1228:
1227:
1209:
1208:
1183:
1182:
1164:
1163:
1112:
1111:
846:NOS2-CD74 complex
627:
626:
623:
622:
592:
591:
579:
578:
517:
516:
415:
414:
314:
313:
141:
140:
137:
136:
61:Ortholog search:
16:(Redirected from
5631:
3591:
3584:
3577:
3568:
3550:
3535:
3520:
3500:
3493:
3486:
3477:
3445:Davidson College
3419:
3409:
3399:
3366:
3329:
3310:10.1038/364033a0
3284:
3274:
3241:
3222:10.1038/378457a0
3196:
3171:(6): 2564β2569.
3159:
3125:
3115:
3105:
3082:The EMBO Journal
3072:
3043:
3014:
3004:
2994:
2961:
2924:
2914:
2881:
2863:
2854:(8): 2589β2594.
2838:
2828:
2795:
2761:
2751:
2732:10.1038/360474a0
2706:
2667:
2666:
2638:
2632:
2631:
2621:
2611:
2587:
2581:
2580:
2570:
2560:
2536:
2530:
2529:
2519:
2509:
2485:
2479:
2478:
2468:
2436:
2430:
2429:
2393:
2387:
2386:
2366:
2360:
2359:
2349:
2339:
2330:(7): 1185β1193.
2315:
2309:
2308:
2283:(6): 1211β1214.
2272:
2266:
2265:
2263:
2261:
2245:
2239:
2238:
2220:
2188:
2182:
2181:
2153:
2147:
2146:
2136:
2104:
2098:
2097:
2071:
2062:
2061:
2051:
2041:
2017:
2011:
2010:
1982:
1976:
1975:
1973:
1971:
1956:
1950:
1949:
1939:
1907:
1901:
1900:
1890:
1880:
1848:
1842:
1841:
1830:
1824:
1823:
1812:
1806:
1796:
1785:
1775:
1612:conserved region
1602:Vaccine adjuvant
1455:
1454:
1426:
1419:
1402:
1386:
1377:
1349:
1345:RefSeq (protein)
1335:
1319:
1310:
1282:
1258:
1239:
1213:
1194:
1168:
1149:
1118:
992:defense response
897:T cell selection
700:cytokine binding
633:
619:
610:
603:
588:
528:
526:Top expressed in
521:
466:
464:Top expressed in
459:
438:
421:
411:
398:
387:
372:
365:
359:
348:
336:
320:
310:
297:
286:
271:
264:
258:
247:
233:
217:
211:
209:CD74 - orthologs
162:
155:
132:
75:
69:
48:
47:
42:
30:
21:
5639:
5638:
5634:
5633:
5632:
5630:
5629:
5628:
5604:
5603:
5602:
5597:
5401:
5195:
4944:
4628:
4351:
4011:
3609:
3595:
3565:
3560:
3557:
3551:
3542:
3536:
3527:
3521:
3507:
3504:
3427:
3422:
3369:
3332:
3296:(6432): 33β39.
3287:
3244:
3199:
3162:
3123:
3118:
3075:
3046:
3017:
2964:
2927:
2884:
2841:
2798:
2759:
2754:
2709:
2680:
2676:
2674:Further reading
2671:
2670:
2640:
2639:
2635:
2589:
2588:
2584:
2538:
2537:
2533:
2487:
2486:
2482:
2457:10.1002/pro.263
2445:Protein Science
2438:
2437:
2433:
2395:
2394:
2390:
2368:
2367:
2363:
2317:
2316:
2312:
2274:
2273:
2269:
2259:
2257:
2247:
2246:
2242:
2190:
2189:
2185:
2155:
2154:
2150:
2106:
2105:
2101:
2086:
2076:Kuby immunology
2073:
2072:
2065:
2019:
2018:
2014:
1984:
1983:
1979:
1969:
1967:
1958:
1957:
1953:
1909:
1908:
1904:
1850:
1849:
1845:
1832:
1831:
1827:
1814:
1813:
1809:
1797:
1788:
1776:
1767:
1762:
1744:
1720:
1703:
1687:
1652:
1640:
1604:
1599:
1543:
1507:invariant chain
1464:View/Edit Mouse
1459:View/Edit Human
1422:
1415:
1412:Location (UCSC)
1398:
1394:
1373:
1369:
1365:
1361:
1357:
1331:
1327:
1306:
1302:
1298:
1294:
1290:
1203:ENSG00000019582
1096:
867:immune response
855:
821:plasma membrane
771:Golgi apparatus
721:lysosomal lumen
709:
690:protein binding
615:
584:
575:
570:
566:
562:
558:
554:
550:
546:
542:
538:
524:
513:
510:mucosa of ileum
508:
504:
500:
496:
492:
488:
484:
480:
476:
462:
406:
393:
385:
375:
374:
373:
366:
346:
323:Gene location (
305:
292:
284:
274:
273:
272:
265:
243:
220:Gene location (
171:
158:
151:
84:
62:
28:
23:
22:
18:Invariant chain
15:
12:
11:
5:
5637:
5635:
5627:
5626:
5621:
5616:
5606:
5605:
5599:
5598:
5596:
5595:
5590:
5585:
5580:
5575:
5570:
5565:
5560:
5555:
5550:
5545:
5540:
5535:
5530:
5525:
5520:
5515:
5510:
5505:
5500:
5495:
5490:
5485:
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5475:
5470:
5465:
5460:
5455:
5450:
5445:
5440:
5435:
5430:
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5420:
5415:
5409:
5407:
5403:
5402:
5400:
5399:
5394:
5389:
5384:
5379:
5374:
5369:
5364:
5359:
5354:
5349:
5344:
5339:
5334:
5329:
5324:
5319:
5314:
5309:
5304:
5299:
5294:
5289:
5284:
5279:
5274:
5269:
5264:
5259:
5254:
5249:
5244:
5239:
5234:
5229:
5224:
5219:
5214:
5209:
5203:
5201:
5197:
5196:
5194:
5193:
5188:
5179:
5174:
5169:
5164:
5159:
5154:
5149:
5144:
5139:
5134:
5133:
5132:
5127:
5117:
5112:
5107:
5102:
5097:
5092:
5087:
5082:
5077:
5072:
5067:
5062:
5057:
5052:
5046:
5037:
5032:
5031:
5030:
5025:
5015:
5010:
5009:
5008:
5003:
4993:
4988:
4983:
4978:
4973:
4968:
4963:
4958:
4952:
4950:
4946:
4945:
4943:
4942:
4937:
4932:
4927:
4922:
4917:
4912:
4907:
4902:
4897:
4892:
4887:
4882:
4877:
4872:
4867:
4862:
4857:
4856:
4855:
4850:
4840:
4835:
4830:
4825:
4824:
4823:
4818:
4813:
4803:
4798:
4793:
4788:
4783:
4782:
4781:
4776:
4766:
4761:
4756:
4751:
4746:
4741:
4736:
4735:
4734:
4729:
4719:
4713:
4708:
4703:
4698:
4689:
4684:
4683:
4682:
4677:
4672:
4662:
4657:
4652:
4647:
4642:
4636:
4634:
4630:
4629:
4627:
4626:
4621:
4616:
4611:
4606:
4601:
4596:
4591:
4586:
4581:
4576:
4571:
4566:
4561:
4556:
4551:
4546:
4541:
4536:
4531:
4526:
4521:
4516:
4511:
4506:
4501:
4500:
4499:
4494:
4484:
4483:
4482:
4477:
4467:
4462:
4457:
4452:
4447:
4442:
4437:
4432:
4427:
4422:
4417:
4412:
4407:
4406:
4405:
4400:
4390:
4385:
4380:
4375:
4370:
4365:
4359:
4357:
4353:
4352:
4350:
4349:
4344:
4339:
4334:
4329:
4324:
4319:
4314:
4309:
4300:
4295:
4290:
4285:
4280:
4275:
4274:
4273:
4268:
4263:
4258:
4253:
4248:
4238:
4233:
4228:
4223:
4218:
4213:
4212:
4211:
4206:
4196:
4191:
4186:
4181:
4176:
4171:
4166:
4161:
4156:
4155:
4154:
4149:
4144:
4139:
4134:
4129:
4119:
4118:
4117:
4112:
4107:
4097:
4092:
4091:
4090:
4085:
4080:
4070:
4065:
4060:
4055:
4050:
4045:
4040:
4035:
4030:
4025:
4019:
4017:
4013:
4012:
4010:
4009:
4004:
4003:
4002:
3997:
3992:
3987:
3982:
3977:
3967:
3962:
3957:
3952:
3947:
3942:
3937:
3936:
3935:
3930:
3925:
3920:
3910:
3905:
3900:
3895:
3890:
3885:
3880:
3875:
3870:
3865:
3864:
3863:
3858:
3848:
3843:
3838:
3833:
3828:
3823:
3818:
3813:
3808:
3803:
3798:
3793:
3788:
3783:
3778:
3777:
3776:
3771:
3761:
3756:
3751:
3746:
3745:
3744:
3739:
3734:
3729:
3719:
3714:
3709:
3708:
3707:
3697:
3692:
3687:
3682:
3677:
3676:
3675:
3670:
3665:
3655:
3650:
3649:
3648:
3643:
3638:
3633:
3628:
3617:
3615:
3611:
3610:
3596:
3594:
3593:
3586:
3579:
3571:
3562:
3561:
3559:
3558:
3552:
3545:
3543:
3537:
3530:
3528:
3522:
3515:
3512:
3509:
3508:
3505:
3503:
3502:
3495:
3488:
3480:
3474:
3473:
3454:
3448:
3438:
3426:
3425:External links
3423:
3421:
3420:
3367:
3341:(2): 257β268.
3330:
3285:
3257:(2): 623β629.
3242:
3197:
3160:
3116:
3088:(4): 869β872.
3073:
3044:
3015:
2962:
2930:Immunogenetics
2925:
2897:(2): 444β460.
2882:
2839:
2811:(3): 839β855.
2796:
2770:(4): 707β716.
2752:
2707:
2677:
2675:
2672:
2669:
2668:
2633:
2582:
2531:
2480:
2431:
2404:(2): 275β283.
2388:
2373:(in Chinese).
2361:
2310:
2267:
2240:
2183:
2164:(4): 150β154.
2148:
2119:(1): 105β111.
2099:
2084:
2063:
2012:
1977:
1951:
1902:
1843:
1825:
1807:
1786:
1764:
1763:
1761:
1758:
1757:
1756:
1750:
1743:
1740:
1719:
1716:
1702:
1699:
1689:CD74 receptor
1686:
1683:
1655:Autoantibodies
1651:
1648:
1639:
1636:
1603:
1600:
1598:
1595:
1542:
1539:
1478:also known as
1471:
1470:
1467:
1466:
1461:
1451:
1450:
1444:
1443:
1440:
1439:
1437:
1435:
1428:
1427:
1420:
1413:
1409:
1408:
1405:
1404:
1390:
1389:
1383:
1380:
1379:
1353:
1352:
1346:
1342:
1341:
1338:
1337:
1323:
1322:
1316:
1313:
1312:
1286:
1285:
1279:
1275:
1274:
1271:
1270:
1262:
1261:
1255:
1252:
1251:
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1236:
1230:
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1217:
1216:
1210:
1207:
1206:
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1191:
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1165:
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1161:
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1152:
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1139:
1134:
1129:
1125:
1124:
1114:
1113:
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1109:
1098:
1097:
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1094:
1089:
1084:
1079:
1074:
1069:
1064:
1059:
1054:
1049:
1044:
1039:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
979:
974:
969:
964:
959:
954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
863:
861:
857:
856:
854:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
776:Golgi membrane
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
717:
715:
711:
710:
708:
707:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
646:
644:
640:
639:
629:
628:
625:
624:
621:
620:
612:
611:
600:
594:
593:
590:
589:
581:
580:
577:
576:
574:
573:
569:
565:
561:
557:
553:
549:
545:
541:
537:
533:
530:
529:
518:
515:
514:
512:
511:
507:
503:
499:
495:
491:
487:
483:
479:
475:
471:
468:
467:
455:
454:
446:
435:
429:
428:
425:RNA expression
417:
416:
413:
412:
404:
400:
399:
391:
388:
383:
377:
376:
367:
360:
354:
350:
349:
344:
338:
337:
329:
328:
316:
315:
312:
311:
303:
299:
298:
290:
287:
282:
276:
275:
266:
259:
253:
249:
248:
241:
235:
234:
226:
225:
213:
212:
169:
165:
164:
156:
148:
147:
143:
142:
139:
138:
135:
134:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5636:
5625:
5624:Immune system
5622:
5620:
5617:
5615:
5612:
5611:
5609:
5594:
5591:
5589:
5586:
5584:
5581:
5579:
5576:
5574:
5571:
5569:
5566:
5564:
5561:
5559:
5556:
5554:
5551:
5549:
5546:
5544:
5541:
5539:
5536:
5534:
5531:
5529:
5526:
5524:
5521:
5519:
5516:
5514:
5511:
5509:
5506:
5504:
5501:
5499:
5496:
5494:
5491:
5489:
5486:
5484:
5481:
5479:
5476:
5474:
5471:
5469:
5466:
5464:
5461:
5459:
5456:
5454:
5451:
5449:
5446:
5444:
5441:
5439:
5436:
5434:
5431:
5429:
5426:
5424:
5421:
5419:
5416:
5414:
5411:
5410:
5408:
5404:
5398:
5395:
5393:
5390:
5388:
5385:
5383:
5380:
5378:
5375:
5373:
5370:
5368:
5365:
5363:
5360:
5358:
5355:
5353:
5350:
5348:
5345:
5343:
5340:
5338:
5335:
5333:
5330:
5328:
5325:
5323:
5320:
5318:
5315:
5313:
5310:
5308:
5305:
5303:
5300:
5298:
5295:
5293:
5290:
5288:
5285:
5283:
5280:
5278:
5275:
5273:
5270:
5268:
5265:
5263:
5260:
5258:
5255:
5253:
5250:
5248:
5245:
5243:
5240:
5238:
5235:
5233:
5230:
5228:
5225:
5223:
5220:
5218:
5215:
5213:
5210:
5208:
5205:
5204:
5202:
5198:
5192:
5189:
5187:
5183:
5180:
5178:
5175:
5173:
5170:
5168:
5165:
5163:
5160:
5158:
5155:
5153:
5150:
5148:
5145:
5143:
5140:
5138:
5135:
5131:
5128:
5126:
5123:
5122:
5121:
5118:
5116:
5113:
5111:
5108:
5106:
5103:
5101:
5098:
5096:
5093:
5091:
5088:
5086:
5083:
5081:
5078:
5076:
5073:
5071:
5068:
5066:
5063:
5061:
5058:
5056:
5053:
5050:
5047:
5045:
5041:
5038:
5036:
5033:
5029:
5026:
5024:
5021:
5020:
5019:
5016:
5014:
5011:
5007:
5004:
5002:
4999:
4998:
4997:
4994:
4992:
4989:
4987:
4984:
4982:
4979:
4977:
4974:
4972:
4969:
4967:
4964:
4962:
4959:
4957:
4954:
4953:
4951:
4947:
4941:
4938:
4936:
4933:
4931:
4928:
4926:
4923:
4921:
4918:
4916:
4913:
4911:
4908:
4906:
4903:
4901:
4898:
4896:
4893:
4891:
4888:
4886:
4883:
4881:
4878:
4876:
4873:
4871:
4868:
4866:
4863:
4861:
4858:
4854:
4851:
4849:
4846:
4845:
4844:
4841:
4839:
4836:
4834:
4831:
4829:
4826:
4822:
4819:
4817:
4814:
4812:
4809:
4808:
4807:
4804:
4802:
4799:
4797:
4794:
4792:
4789:
4787:
4784:
4780:
4777:
4775:
4772:
4771:
4770:
4767:
4765:
4762:
4760:
4757:
4755:
4752:
4750:
4747:
4745:
4742:
4740:
4737:
4733:
4730:
4728:
4725:
4724:
4723:
4720:
4717:
4714:
4712:
4709:
4707:
4704:
4702:
4699:
4697:
4693:
4690:
4688:
4685:
4681:
4678:
4676:
4673:
4671:
4668:
4667:
4666:
4663:
4661:
4658:
4656:
4653:
4651:
4648:
4646:
4643:
4641:
4638:
4637:
4635:
4631:
4625:
4622:
4620:
4617:
4615:
4612:
4610:
4607:
4605:
4602:
4600:
4597:
4595:
4592:
4590:
4587:
4585:
4582:
4580:
4577:
4575:
4572:
4570:
4567:
4565:
4562:
4560:
4557:
4555:
4552:
4550:
4547:
4545:
4542:
4540:
4537:
4535:
4532:
4530:
4527:
4525:
4522:
4520:
4517:
4515:
4512:
4510:
4507:
4505:
4502:
4498:
4495:
4493:
4490:
4489:
4488:
4485:
4481:
4478:
4476:
4473:
4472:
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4453:
4451:
4448:
4446:
4443:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4404:
4401:
4399:
4396:
4395:
4394:
4391:
4389:
4386:
4384:
4381:
4379:
4376:
4374:
4371:
4369:
4366:
4364:
4361:
4360:
4358:
4354:
4348:
4345:
4343:
4340:
4338:
4335:
4333:
4330:
4328:
4325:
4323:
4320:
4318:
4315:
4313:
4310:
4308:
4304:
4301:
4299:
4296:
4294:
4291:
4289:
4286:
4284:
4281:
4279:
4276:
4272:
4269:
4267:
4264:
4262:
4259:
4257:
4254:
4252:
4249:
4247:
4244:
4243:
4242:
4239:
4237:
4234:
4232:
4229:
4227:
4224:
4222:
4219:
4217:
4214:
4210:
4207:
4205:
4202:
4201:
4200:
4197:
4195:
4192:
4190:
4187:
4185:
4182:
4180:
4177:
4175:
4172:
4170:
4167:
4165:
4162:
4160:
4157:
4153:
4150:
4148:
4145:
4143:
4140:
4138:
4135:
4133:
4130:
4128:
4125:
4124:
4123:
4120:
4116:
4113:
4111:
4108:
4106:
4103:
4102:
4101:
4098:
4096:
4093:
4089:
4086:
4084:
4081:
4079:
4076:
4075:
4074:
4071:
4069:
4066:
4064:
4061:
4059:
4056:
4054:
4051:
4049:
4046:
4044:
4041:
4039:
4036:
4034:
4031:
4029:
4026:
4024:
4021:
4020:
4018:
4014:
4008:
4005:
4001:
3998:
3996:
3993:
3991:
3988:
3986:
3983:
3981:
3978:
3976:
3973:
3972:
3971:
3968:
3966:
3963:
3961:
3958:
3956:
3953:
3951:
3948:
3946:
3943:
3941:
3938:
3934:
3931:
3929:
3926:
3924:
3921:
3919:
3916:
3915:
3914:
3911:
3909:
3906:
3904:
3901:
3899:
3896:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3876:
3874:
3871:
3869:
3866:
3862:
3859:
3857:
3854:
3853:
3852:
3849:
3847:
3844:
3842:
3839:
3837:
3834:
3832:
3829:
3827:
3824:
3822:
3819:
3817:
3814:
3812:
3809:
3807:
3804:
3802:
3799:
3797:
3794:
3792:
3789:
3787:
3784:
3782:
3779:
3775:
3772:
3770:
3767:
3766:
3765:
3762:
3760:
3757:
3755:
3752:
3750:
3747:
3743:
3740:
3738:
3735:
3733:
3730:
3728:
3725:
3724:
3723:
3720:
3718:
3715:
3713:
3710:
3706:
3703:
3702:
3701:
3698:
3696:
3693:
3691:
3688:
3686:
3683:
3681:
3678:
3674:
3671:
3669:
3666:
3664:
3661:
3660:
3659:
3656:
3654:
3651:
3647:
3644:
3642:
3639:
3637:
3634:
3632:
3629:
3627:
3624:
3623:
3622:
3619:
3618:
3616:
3612:
3607:
3603:
3599:
3592:
3587:
3585:
3580:
3578:
3573:
3572:
3569:
3555:
3549:
3544:
3540:
3534:
3529:
3525:
3519:
3514:
3510:
3501:
3496:
3494:
3489:
3487:
3482:
3481:
3478:
3471:
3467:
3466:
3461:
3460:
3455:
3452:
3449:
3446:
3442:
3439:
3436:
3432:
3429:
3428:
3424:
3417:
3413:
3408:
3403:
3398:
3393:
3389:
3385:
3381:
3377:
3373:
3368:
3364:
3360:
3356:
3352:
3348:
3344:
3340:
3336:
3331:
3327:
3323:
3319:
3315:
3311:
3307:
3303:
3299:
3295:
3291:
3286:
3282:
3278:
3273:
3268:
3264:
3260:
3256:
3252:
3248:
3243:
3239:
3235:
3231:
3227:
3223:
3219:
3215:
3211:
3207:
3203:
3198:
3194:
3190:
3186:
3182:
3178:
3174:
3170:
3166:
3161:
3157:
3153:
3149:
3145:
3141:
3137:
3133:
3129:
3122:
3117:
3113:
3109:
3104:
3099:
3095:
3091:
3087:
3083:
3079:
3074:
3070:
3066:
3062:
3058:
3054:
3050:
3045:
3041:
3037:
3033:
3029:
3025:
3021:
3016:
3012:
3008:
3003:
2998:
2993:
2988:
2984:
2980:
2976:
2972:
2968:
2963:
2959:
2955:
2951:
2947:
2943:
2939:
2935:
2931:
2926:
2922:
2918:
2913:
2908:
2904:
2900:
2896:
2892:
2888:
2883:
2879:
2875:
2871:
2867:
2862:
2857:
2853:
2849:
2845:
2840:
2836:
2832:
2827:
2822:
2818:
2814:
2810:
2806:
2802:
2797:
2793:
2789:
2785:
2781:
2777:
2773:
2769:
2765:
2758:
2753:
2749:
2745:
2741:
2737:
2733:
2729:
2725:
2721:
2717:
2713:
2708:
2704:
2700:
2696:
2692:
2688:
2684:
2679:
2678:
2673:
2664:
2660:
2656:
2652:
2648:
2644:
2637:
2634:
2629:
2625:
2620:
2615:
2610:
2605:
2601:
2597:
2593:
2586:
2583:
2578:
2574:
2569:
2564:
2559:
2554:
2550:
2546:
2542:
2535:
2532:
2527:
2523:
2518:
2513:
2508:
2503:
2499:
2495:
2491:
2484:
2481:
2476:
2472:
2467:
2462:
2458:
2454:
2450:
2446:
2442:
2435:
2432:
2427:
2423:
2419:
2415:
2411:
2407:
2403:
2399:
2392:
2389:
2384:
2380:
2376:
2372:
2365:
2362:
2357:
2353:
2348:
2343:
2338:
2333:
2329:
2325:
2321:
2314:
2311:
2306:
2302:
2298:
2294:
2290:
2286:
2282:
2278:
2271:
2268:
2255:
2251:
2244:
2241:
2236:
2232:
2228:
2224:
2219:
2214:
2210:
2206:
2202:
2198:
2194:
2187:
2184:
2179:
2175:
2171:
2167:
2163:
2159:
2152:
2149:
2144:
2140:
2135:
2130:
2126:
2122:
2118:
2114:
2110:
2103:
2100:
2095:
2091:
2087:
2081:
2077:
2070:
2068:
2064:
2059:
2055:
2050:
2045:
2040:
2035:
2031:
2027:
2023:
2016:
2013:
2008:
2004:
2000:
1996:
1992:
1988:
1981:
1978:
1965:
1961:
1955:
1952:
1947:
1943:
1938:
1933:
1929:
1925:
1921:
1917:
1913:
1906:
1903:
1898:
1894:
1889:
1884:
1879:
1874:
1870:
1866:
1862:
1858:
1854:
1847:
1844:
1839:
1835:
1829:
1826:
1821:
1817:
1811:
1808:
1804:
1800:
1795:
1793:
1791:
1787:
1783:
1779:
1774:
1772:
1770:
1766:
1759:
1754:
1751:
1749:
1746:
1745:
1741:
1739:
1737:
1733:
1729:
1725:
1724:Hugh McDevitt
1717:
1715:
1707:
1700:
1698:
1696:
1692:
1684:
1682:
1680:
1676:
1672:
1668:
1664:
1660:
1656:
1649:
1647:
1645:
1637:
1635:
1633:
1628:
1625:
1621:
1617:
1613:
1609:
1601:
1596:
1594:
1592:
1587:
1584:
1580:
1576:
1572:
1568:
1564:
1560:
1554:
1552:
1548:
1540:
1538:
1536:
1532:
1528:
1524:
1520:
1516:
1512:
1509:(Abbreviated
1508:
1504:
1501:
1497:
1493:
1489:
1485:
1481:
1477:
1465:
1460:
1456:
1452:
1449:
1445:
1438:
1436:
1433:
1429:
1425:
1421:
1418:
1414:
1410:
1403:
1401:
1397:
1391:
1387:
1384:
1378:
1376:
1372:
1368:
1364:
1360:
1354:
1350:
1347:
1343:
1336:
1334:
1330:
1324:
1320:
1317:
1311:
1309:
1305:
1301:
1297:
1293:
1287:
1283:
1280:
1278:RefSeq (mRNA)
1276:
1269:
1268:
1263:
1259:
1256:
1250:
1249:
1244:
1240:
1237:
1235:
1231:
1224:
1223:
1218:
1214:
1211:
1205:
1204:
1199:
1195:
1192:
1190:
1186:
1179:
1178:
1173:
1169:
1166:
1160:
1159:
1154:
1150:
1147:
1145:
1141:
1138:
1135:
1133:
1130:
1126:
1123:
1119:
1115:
1108:
1104:
1099:
1093:
1090:
1088:
1085:
1083:
1080:
1078:
1075:
1073:
1070:
1068:
1065:
1063:
1060:
1058:
1055:
1053:
1050:
1048:
1045:
1043:
1040:
1038:
1035:
1033:
1030:
1028:
1025:
1023:
1020:
1018:
1015:
1013:
1010:
1008:
1005:
1003:
1000:
998:
995:
993:
990:
988:
985:
983:
980:
978:
975:
973:
970:
968:
965:
963:
960:
958:
955:
953:
950:
948:
945:
943:
940:
938:
935:
933:
930:
928:
925:
923:
920:
918:
915:
913:
910:
908:
905:
903:
900:
898:
895:
893:
890:
888:
885:
883:
880:
878:
875:
873:
870:
868:
865:
864:
862:
859:
858:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
741:late endosome
739:
737:
734:
732:
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668:
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663:
661:
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648:
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645:
642:
641:
638:
637:Gene ontology
634:
630:
618:
613:
609:
604:
601:
599:
595:
587:
582:
571:
568:adrenal gland
567:
563:
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531:
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4842:
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4392:
4240:
4188:
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3538:
3523:
3464:
3458:
3379:
3375:
3338:
3334:
3293:
3289:
3254:
3250:
3205:
3201:
3168:
3164:
3134:(1): 61β69.
3131:
3127:
3085:
3081:
3052:
3049:Biochemistry
3048:
3023:
3020:Biochemistry
3019:
2974:
2970:
2936:(1): 53β56.
2933:
2929:
2894:
2890:
2851:
2847:
2808:
2804:
2767:
2763:
2715:
2711:
2689:(1): 57β64.
2686:
2682:
2649:(1): 51β60.
2646:
2642:
2636:
2599:
2595:
2585:
2548:
2544:
2534:
2497:
2493:
2483:
2448:
2444:
2434:
2401:
2397:
2391:
2374:
2370:
2364:
2327:
2323:
2313:
2280:
2276:
2270:
2258:. Retrieved
2253:
2243:
2200:
2196:
2186:
2161:
2157:
2151:
2116:
2112:
2102:
2075:
2029:
2025:
2015:
1990:
1986:
1980:
1968:. Retrieved
1963:
1954:
1919:
1915:
1905:
1860:
1856:
1846:
1837:
1828:
1819:
1810:
1731:
1727:
1721:
1712:
1688:
1685:Interactions
1653:
1641:
1629:
1608:viral vector
1605:
1588:
1555:
1545:The nascent
1544:
1523:MHC class II
1510:
1506:
1499:
1491:
1487:
1483:
1479:
1475:
1474:
1396:NP_001036070
1393:
1375:NP_001351013
1371:NP_001351012
1363:NP_001020330
1359:NP_001020329
1356:
1329:NM_001042605
1326:
1308:NM_001364084
1304:NM_001364083
1300:NM_001025159
1296:NM_001025158
1289:
1265:
1246:
1220:
1201:
1175:
1156:
1136:
1131:
796:cell surface
552:zone of skin
448:
441:
306:150,412,969
293:150,401,637
168:External IDs
83:
3506:PDB gallery
1993:: 259β293.
1753:Milatuzumab
1644:milatuzumab
1624:HCV vaccine
1571:cathepsin L
1567:cathepsin S
1563:MHC class I
1527:CD4+ T cell
1515:polypeptide
498:gallbladder
482:granulocyte
407:60,945,724
394:60,936,920
146:Identifiers
5608:Categories
3604:(see also
2545:BMC Cancer
1805:, May 2017
1784:, May 2017
1760:References
1659:biomarkers
1490:luster of
494:right lung
490:lymph node
452:(ortholog)
189:HomoloGene
2235:219722045
2094:820117219
1691:interacts
1591:presented
1400:NP_034675
1367:NP_004346
1333:NM_010545
1292:NM_004355
1122:Orthologs
197:GeneCards
3598:Proteins
3441:Overview
3363:10295196
3193:42620266
2792:19993336
2703:16454711
2628:32655566
2602:: 1273.
2577:19602265
2526:19759012
2475:19827093
2426:38141283
2418:20005040
2383:20034881
2356:31677380
2305:22939188
2297:23687263
2227:32554708
2178:10322421
2143:22138314
2058:32655566
2032:: 1273.
1801:–
1780:–
1742:See also
1620:adjuvant
1559:endosome
1541:Function
1448:Wikidata
1101:Sources:
836:endosome
826:lysosome
791:membrane
478:appendix
474:monocyte
5406:301β350
5200:251β300
5152:CD240CE
4949:201β250
4633:151β200
4356:101β150
3416:8397411
3384:Bibcode
3355:8343954
3326:4248668
3318:8316295
3298:Bibcode
3281:7519244
3272:2191624
3238:4275956
3230:7477400
3210:Bibcode
3185:6982931
3156:9066996
3148:6955026
3112:6586420
3069:6576808
3040:3866610
3011:3459184
2979:Bibcode
2958:2418453
2950:3132422
2921:3036998
2912:2189580
2878:6755576
2870:2507633
2835:2391366
2826:2116304
2784:2121367
2748:4338656
2740:1448172
2720:Bibcode
2619:7325688
2568:2716369
2551:: 230.
2517:2781663
2466:2798171
2347:7325720
2260:Aug 10,
2218:7610808
2134:3288754
2049:7325688
2007:8011283
1970:Aug 10,
1946:3001652
1897:6324166
1865:Bibcode
1803:Ensembl
1782:Ensembl
1718:History
1665:called
1614:of the
1537:(MIF).
1513:) is a
1496:protein
1234:UniProt
1189:Ensembl
1128:Species
1107:QuickGO
831:vacuole
540:jejunum
427:pattern
153:Aliases
5413:CD300A
5372:CDw293
5157:CD240D
5018:CD213a
4996:CDw210
4961:CD202b
4935:CDw199
4930:CDw198
4584:CD140b
4016:51β100
3456:Human
3437:(MeSH)
3414:
3404:
3361:
3353:
3324:
3316:
3290:Nature
3279:
3269:
3236:
3228:
3202:Nature
3191:
3183:
3154:
3146:
3110:
3103:557440
3100:
3067:
3038:
3009:
3002:323758
2999:
2956:
2948:
2919:
2909:
2876:
2868:
2833:
2823:
2790:
2782:
2746:
2738:
2712:Nature
2701:
2663:376435
2661:
2626:
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2575:
2565:
2524:
2514:
2473:
2463:
2424:
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2354:
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2295:
2233:
2225:
2215:
2176:
2141:
2131:
2092:
2082:
2056:
2046:
2005:
1944:
1937:318954
1934:
1895:
1888:389957
1885:
1638:Cancer
1622:for a
1583:HLA-DM
1505:. The
1434:search
1432:PubMed
1267:P04441
1248:P04233
1144:Entrez
598:BioGPS
564:uterus
544:thymus
536:spleen
486:spleen
285:5q33.1
177:142790
5593:CD350
5588:CD349
5583:CD344
5578:CD340
5573:CD339
5568:CD338
5563:CD337
5558:CD336
5553:CD335
5548:CD334
5543:CD333
5538:CD332
5533:CD331
5528:CD329
5523:CD328
5518:CD327
5513:CD326
5508:CD325
5503:CD324
5498:CD322
5493:CD321
5488:CD320
5483:CD318
5478:CD317
5473:CD316
5468:CD315
5463:CD314
5458:CD312
5453:CD309
5448:CD307
5443:CD306
5438:CD305
5433:CD304
5428:CD303
5423:CD302
5418:CD301
5397:CD299
5392:CD298
5387:CD297
5382:CD295
5377:CD294
5367:CD292
5362:CD290
5357:CD289
5352:CD288
5347:CD286
5342:CD284
5337:CD283
5332:CD282
5327:CD281
5322:CD280
5317:CD279
5312:CD278
5307:CD276
5302:CD275
5297:CD274
5292:CD273
5287:CD272
5282:CD271
5277:CD269
5272:CD268
5267:CD267
5262:CD266
5257:CD265
5252:CD264
5247:CD263
5242:CD262
5237:CD261
5232:CD258
5227:CD257
5222:CD256
5217:CD254
5212:CD253
5207:CD252
5191:CD249
5186:CD248
5182:CD247
5177:CD246
5172:CD244
5167:CD243
5162:CD241
5147:CD239
5142:CD238
5137:CD236
5120:CD235
5115:CD234
5110:CD233
5105:CD230
5100:CD229
5095:CD228
5090:CD227
5085:CD226
5080:CD225
5075:CD224
5070:CD223
5065:CD222
5060:CD221
5055:CD220
5040:CD218
5035:CD217
5013:CD212
4991:CD209
4986:CD208
4981:CD207
4976:CD206
4971:CD205
4966:CD204
4956:CD201
4940:CD200
4925:CD197
4920:CD196
4915:CD195
4910:CD194
4905:CD193
4900:CD192
4895:CD191
4890:CD186
4885:CD185
4880:CD184
4875:CD183
4870:CD182
4865:CD181
4860:CD180
4843:CD179
4838:CD178
4833:CD177
4828:CD174
4806:CD172
4801:CD171
4796:CD170
4791:CD169
4786:CD168
4769:CD167
4764:CD166
4759:CD164
4754:CD163
4749:CD162
4744:CD161
4739:CD160
4722:CD159
4692:CD158
4687:CD157
4665:CD156
4660:CD155
4655:CD154
4650:CD153
4645:CD152
4640:CD151
4624:CD150
4619:CD148
4614:CD147
4609:CD146
4604:CD144
4599:CD143
4594:CD142
4589:CD141
4579:CD138
4574:CD137
4569:CD136
4564:CD135
4559:CD134
4554:CD133
4549:CD132
4544:CD131
4539:CD130
4534:CD129
4529:CD127
4524:CD126
4519:CD125
4514:CD124
4509:CD123
4504:CD122
4487:CD121
4470:CD120
4465:CD119
4460:CD118
4455:CD117
4450:CD116
4445:CD115
4440:CD114
4435:CD113
4430:CD112
4425:CD111
4420:CD110
4415:CD109
4410:CD108
4393:CD107
4388:CD106
4383:CD105
4378:CD104
4373:CD103
4368:CD102
4363:CD101
4347:CD100
3407:47401
3359:S2CID
3322:S2CID
3234:S2CID
3189:S2CID
3152:S2CID
3124:(PDF)
2954:S2CID
2874:S2CID
2788:S2CID
2760:(PDF)
2744:S2CID
2422:S2CID
2301:S2CID
2231:S2CID
1610:to a
1177:16149
1137:Mouse
1132:Human
1103:Amigo
556:colon
548:ileum
450:Mouse
443:Human
390:Start
325:Mouse
289:Start
222:Human
185:96534
4342:CD99
4337:CD98
4332:CD97
4327:CD96
4322:CD95
4317:CD94
4312:CD93
4307:CD92
4303:CD91
4298:CD90
4293:CD89
4288:CD88
4283:CD87
4278:CD86
4241:CD85
4236:CD84
4231:CD83
4226:CD82
4221:CD81
4216:CD80
4199:CD79
4194:CD78
4189:CD74
4184:CD73
4179:CD72
4174:CD71
4169:CD70
4164:CD69
4159:CD68
4122:CD66
4100:CD64
4095:CD63
4073:CD62
4068:CD61
4063:CD59
4058:CD58
4053:CD57
4048:CD56
4043:CD55
4038:CD54
4033:CD53
4028:CD52
4023:CD51
4007:CD50
3970:CD49
3965:CD48
3960:CD47
3955:CD46
3950:CD45
3945:CD44
3940:CD43
3913:CD42
3908:CD41
3903:CD40
3898:CD39
3893:CD38
3888:CD37
3883:CD36
3878:CD35
3873:CD34
3868:CD33
3851:CD32
3846:CD31
3841:CD30
3836:CD29
3831:CD28
3826:CD27
3821:CD26
3816:CD25
3811:CD24
3806:CD23
3801:CD22
3796:CD21
3791:CD20
3786:CD19
3781:CD18
3764:CD16
3759:CD15
3754:CD14
3749:CD13
3722:CD11
3717:CD10
3614:1β50
3554:1l3h
3539:1iie
3524:1icf
3465:CD74
3459:CD74
3412:PMID
3351:PMID
3335:Cell
3314:PMID
3277:PMID
3226:PMID
3181:PMID
3144:PMID
3128:Cell
3108:PMID
3065:PMID
3036:PMID
3007:PMID
2946:PMID
2917:PMID
2866:PMID
2831:PMID
2780:PMID
2764:Cell
2736:PMID
2699:PMID
2659:PMID
2624:PMID
2573:PMID
2522:PMID
2471:PMID
2414:PMID
2398:Pain
2379:PMID
2352:PMID
2293:PMID
2262:2020
2223:PMID
2174:PMID
2139:PMID
2090:OCLC
2080:ISBN
2054:PMID
2003:PMID
1972:2020
1942:PMID
1893:PMID
1730:for
1681:).
1673:and
1579:CLIP
1503:gene
1500:CD74
1484:CD74
433:Bgee
381:Band
342:Chr.
280:Band
239:Chr.
201:CD74
193:3209
173:OMIM
160:CD74
130:4X5W
126:4AEN
122:3QXD
118:3QXA
114:3PGD
110:3PGC
106:3PDO
102:1MUJ
98:1L3H
94:1IIE
90:1ICF
86:1A6A
67:RCSB
64:PDBe
33:CD74
3712:CD9
3700:CD8
3695:CD7
3690:CD6
3685:CD5
3680:CD4
3658:CD3
3653:CD2
3626:a-c
3621:CD1
3443:at
3402:PMC
3392:doi
3343:doi
3306:doi
3294:364
3267:PMC
3259:doi
3255:180
3218:doi
3206:378
3173:doi
3169:129
3136:doi
3098:PMC
3090:doi
3057:doi
3028:doi
2997:PMC
2987:doi
2938:doi
2907:PMC
2899:doi
2895:166
2856:doi
2852:143
2821:PMC
2813:doi
2809:111
2772:doi
2728:doi
2716:360
2691:doi
2651:doi
2614:PMC
2604:doi
2563:PMC
2553:doi
2512:PMC
2502:doi
2498:284
2461:PMC
2453:doi
2406:doi
2402:148
2342:PMC
2332:doi
2328:221
2285:doi
2213:PMC
2205:doi
2166:doi
2129:PMC
2121:doi
2044:PMC
2034:doi
1995:doi
1932:PMC
1924:doi
1883:PMC
1873:doi
1738:.
1573:in
1547:MHC
1482:or
1158:972
560:lip
403:End
302:End
205:OMA
181:MGI
57:PDB
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