428:
691:
29:
3178:
890:
Product labeling for diagnostic I iobenguane recommends giving potassium iodide one day before injection and continuing 5 to 7 days following. I iobenguane used for therapeutic purposes requires a different pre-medication duration, beginning 24–48 hours before iobenguane injection and continuing
863:
Thyroid blockade with (nonradioactive) potassium iodide is indicated for nuclear medicine scintigraphy with iobenguane/mIBG. This competitively inhibits radioiodine uptake, preventing excessive radioiodine levels in the thyroid and minimizing risk of thyroid ablation (in treatment with I). The
709:
due to unwanted uptake of iodide radioiodine from breakdown of the pharmaceutical, by the thyroid gland in the neck. Uptake at the side of the head are from the salivary glands. Radioactivity is also seen in the bladder, from normal renal excretion of
812:
can offer significantly higher cost-effectiveness and availability compared to PET imaging, and is particularly effective where I-MIBG therapy is subsequently planned, due to their directly comparable uptake.
1284:"European Association of Nuclear Medicine Practice Guideline/Society of Nuclear Medicine and Molecular Imaging Procedure Standard 2019 for radionuclide imaging of phaeochromocytoma and paraganglioma"
1090:
Metaiodobenzylguanidine (MIBG) is a radiolabeled analogue of guanethidine that enters the cells via the norepinephrine transporter and is either stored in the cytoplasm or in secretory granules
2844:
1815:
108:
556:
1467:"Comparison of metaiodobenzylguanidine scintigraphy with positron emission tomography in the diagnostic work-up of pheochromocytoma and paraganglioma: a systematic review"
2837:
1102:
1808:
512:
1027:
Scarsbrook AF, Ganeshan A, Statham J, Thakker RV, Weaver A, Talbot D, et al. (2007). "Anatomic and functional imaging of metastatic carcinoid tumors".
2617:
2830:
3198:
1801:
1599:
Giammarile F, Chiti A, Lassmann M, Brans B, Flux G (May 2008). "EANM procedure guidelines for 131I-meta-iodobenzylguanidine (131I-mIBG) therapy".
1144:
Metaiodobenzylguanidine (MIBG) is transported to and stored in the distal storage granules of chromaffin cells in the same way as norepinephrine.
2025:
1247:
1137:
1083:
1466:
2168:
2185:
774:
originating in the adrenal glands. It can detect both intra and extra-adrenal disease. The imaging is highly sensitive and specific.
3203:
2180:
1687:
532:
2029:
1965:
1916:
1854:
958:
932:
3213:
908:, has had a clinical trial as a treatment for malignant, recurrent or unresectable pheochromocytoma and paraganglioma, and the
498:
196:
160:
64:
3058:
2158:
2124:
2114:
2057:
1850:
3218:
1961:
3168:
2568:
2246:
2163:
2119:
2052:
805:
684:
313:
2881:
2263:
2087:
645:. The process in which this occurs is closely related to the mechanism employed by norepinephrine and its transporter
407:
83:
2199:
650:
705:
from radioiodine in the MIBG. Two images are seen of the same patient from front and back. Note dark image of the
2538:
581:
2334:
2241:
2067:
852:
778:
788:
Alternatives to imaging with I-MIBG, for certain indications and under clinical and research use, include the
1683:
94:
1748:
1838:
2502:
1117:
1063:
2472:
2399:
396:
2945:
2592:
2518:
2513:
2432:
2077:
1939:
1782:
838:
1333:
Das S, Gordián-Vélez WJ, Ledebur HC, Mourkioti F, Rompolas P, Chen HI, et al. (December 2020).
423:
3208:
2932:
876:
673:
into m-iodohippuric acid (MIHA), and the mechanism for how this metabolite is produced is unknown.
588:
213:
101:
2583:
2457:
2452:
2317:
2301:
2270:
2236:
2040:
2003:
1893:
1723:
1624:
1447:
1253:
1096:
1009:
658:
2523:
1384:
Sisson JC, Shapiro B, Meyers L, Mallette S, Mangner TJ, Wieland DM, et al. (October 1987).
879:
containing 100 mg iodide, weight adjusted for children and given an hour before injection.
2462:
1770:
661:
and adrenal chromaffin cells. MIBG, by bonding to NET, finds its roles in imaging and therapy.
2854:
2558:
2447:
2442:
2394:
2364:
1889:
1869:
1825:
1726:. Billerica, MA: Progenics Pharmaceuticals Inc., a Lantheus company. July 2018. Archived from
1665:
1616:
1578:
1529:
1478:
1439:
1397:
1366:
1315:
1243:
1227:
1208:
1133:
1079:
1044:
1001:
789:
763:
697:
seen as dark sphere in center of the body (it is in the left adrenal gland). Image is by MIBG
592:
376:
175:
41:
1976:
1879:
1874:
1864:
1655:
1608:
1568:
1560:
1519:
1509:
1431:
1418:
Bar-Sever Z, Biassoni L, Shulkin B, Kong G, Hofman MS, Lopci E, et al. (October 2018).
1356:
1346:
1305:
1295:
1235:
1198:
1190:
1174:
1125:
1071:
1036:
993:
872:
723:
694:
618:
600:
444:
1498:"Current diagnostic imaging of pheochromocytomas and implications for therapeutic strategy"
1419:
1282:
Taïeb D, Hicks RJ, Hindié E, Guillet BA, Avram A, Ghedini P, et al. (September 2019).
329:
322:
302:
230:
222:
3182:
2990:
2868:
2331:
2251:
1904:
1709:
848:
739:
735:
715:
638:
427:
2822:
1793:
3098:
3044:
2978:
2794:
2680:
2280:
2153:
2110:
2048:
2021:
1957:
1912:
1846:
1573:
1548:
1524:
1497:
1386:"Metaiodobenzylguanidine to map scintigraphically the adrenergic nervous system in man"
1361:
1334:
1310:
1283:
1203:
1178:
1129:
1075:
654:
604:
584:
690:
3192:
3123:
3019:
3011:
2497:
2420:
2347:
1013:
997:
984:
Olecki E, Grant CN (December 2019). "MIBG in neuroblastoma diagnosis and treatment".
912:
719:
629:
it can also be used to treat tumor cells that take up and metabolize norepinephrine.
622:
1451:
1257:
3156:
3143:
3138:
3118:
3088:
3054:
3039:
3024:
2996:
2969:
2892:
2888:
2876:
2858:
2812:
2799:
2784:
2685:
2670:
2621:
2528:
2467:
2312:
2098:
1829:
1628:
1156:
809:
797:
782:
767:
759:
751:
698:
642:
613:
It localizes to adrenergic tissue and thus can be used to identify the location of
607:
596:
262:
143:
138:
132:
127:
121:
116:
255:
1385:
1239:
726:. It also accumulates in norepinephrine transporters in adrenergic nerves in the
3133:
3093:
3064:
3001:
2957:
2789:
2779:
2769:
2764:
2729:
2714:
2675:
2665:
2630:
2588:
2487:
2415:
2369:
2231:
2073:
2016:
1988:
1885:
1496:Čtvrtlík F, Koranda P, Schovánek J, Škarda J, Hartmann I, Tüdös Z (April 2018).
822:
670:
1300:
847:
radionuclide I for the treatment of certain pheochromocytomas, paragangliomas,
3148:
3128:
3113:
3103:
3049:
3034:
3029:
2986:
2952:
2940:
2912:
2903:
2759:
2754:
2749:
2744:
2739:
2734:
2660:
2655:
2650:
2645:
2640:
2598:
2543:
2508:
2491:
2482:
2437:
2404:
2389:
2384:
2297:
2293:
2288:
2218:
2205:
2192:
2175:
2135:
2130:
2083:
2063:
1935:
1860:
1612:
1435:
1351:
887:, suggest a variety of regimes in clinical use, for both children and adults.
844:
793:
755:
626:
474:
293:
2804:
2774:
2724:
2719:
2709:
2690:
2635:
2609:
2573:
2427:
2409:
2353:
2343:
2258:
2102:
2011:
1945:
1660:
1643:
1177:, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, et al. (January 2018).
702:
1669:
1620:
1582:
1533:
1482:
1443:
1370:
1319:
1212:
1048:
1005:
20:
1514:
1401:
1194:
3108:
3069:
2327:
1564:
1040:
915:
it on July 30, 2018. The drug is developed by
Progenics Pharmaceuticals.
771:
273:
78:
777:
Iobenguane concentrates in presynaptic terminals of the heart and other
282:
2476:
2359:
1980:
706:
646:
540:
InChI=1S/C8H10IN3/c9-7-3-1-2-6(4-7)5-12-8(10)11/h1-4H,5H2,(H4,10,11,12)
241:
28:
2613:
2563:
2548:
1992:
1549:"Theranostic radiopharmaceuticals: established agents in current use"
826:
747:
637:
MIBG is absorbed by and accumulated in granules of adrenal medullary
387:
1465:
Rufini V, Treglia G, Castaldi P, Perotti G, Giordano A (June 2013).
1335:"Innervation: the missing link for biofabricated tissues and organs"
1124:(5th ed.). Philadelphia: Saunders/Elsevier. pp. 872–894.
356:
349:
2577:
2533:
2145:
1927:
884:
801:
743:
727:
689:
614:
497:
488:
367:
1684:"Drug Approval Package: AdreView (Iobenguane I 123) NDA # 022290"
2929:
2553:
2379:
2374:
1950:
1644:"123I-MIBG Imaging: Patient Preparation and Technologist's Role"
1179:"DrugBank 5.0: a major update to the DrugBank database for 2018"
880:
731:
340:
2826:
1797:
1471:
The
Quarterly Journal of Nuclear Medicine and Molecular Imaging
169:
73:
1710:"Iobenguane Sulfate I 131 Injection Diagnostic package insert"
909:
868:
1712:. Bedford, MA: CIS-US, Inc. July 1999 – via Drugs.com.
864:
minimal risk of thyroid cancer is also reduced as a result.
412:
1601:
European
Journal of Nuclear Medicine and Molecular Imaging
1424:
European
Journal of Nuclear Medicine and Molecular Imaging
1288:
European
Journal of Nuclear Medicine and Molecular Imaging
1420:"Guidelines on nuclear medicine imaging in neuroblastoma"
563:
1749:"FDA approves first treatment for rare adrenal tumors"
1727:
3166:
3010:
2977:
2968:
2928:
2902:
2866:
2608:
2326:
2311:
2279:
2144:
2097:
2039:
2002:
1975:
1926:
1903:
1837:
1230:. In Gouliamos AD, Andreou JA, Kosmidis PA (eds.).
821:Side effects post imaging are rare but can include
683:"MIBG scan" redirects here. For the MIBI scan, see
486:
473:
443:
438:
406:
386:
366:
339:
312:
292:
272:
240:
212:
187:
159:
154:
107:
93:
63:
50:
40:
35:
1413:
1411:
904:Iobenguane I 131, marketed under the trade name
871:-approved commercial I-MIBG product Adreview is
785:use as an in vivo probe to study these systems.
603:diagnostic and therapy techniques as well as in
261:
254:
641:, as well as in pre-synaptic adrenergic neuron
229:
221:
1594:
1592:
1120:. In Holcomb GW, Murphy JP, Ostlie DJ (eds.).
959:"Azedra- iobenguane i-131 injection, solution"
2838:
1809:
1277:
1275:
1273:
1271:
1269:
1267:
750:, as well as in tumors that originate in the
8:
1064:"Molecular Imaging of Merkel Cell Carcinoma"
669:Less than 10% of the administered MIBG gets
82:
19:
180:In general: ℞ (Prescription only)
2974:
2845:
2831:
2823:
2323:
1816:
1802:
1794:
1101:: CS1 maint: location missing publisher (
1066:. In Hamblin MR, Avci P, Gupta GK (eds.).
1062:Beylergil V, Perez JA, Osborne JR (2016).
653:(NET) functions to provide norepinephrine
426:
301:
27:
1659:
1572:
1523:
1513:
1360:
1350:
1309:
1299:
1202:
796:, and other radiopharmaceuticals such as
328:
321:
1642:Van Vickle SS, Thompson RC (June 2015).
758:it serves as a whole-body, non-invasive
3173:
924:
580:, is an aralkylguanidine analog of the
537:
517:
422:
281:
201:
2813:Therapeutic radiopharmaceuticals (V10)
1648:Journal of Nuclear Medicine Technology
1094:
933:"Adreview- iobenguane i-123 injection"
18:
3157:Diagnostic radiopharmaceuticals (V09)
1502:Experimental and Therapeutic Medicine
587:(noradrenaline), typically used as a
395:
375:
7:
142:
131:
120:
843:MIBG can be radiolabelled with the
355:
348:
245:
1130:10.1016/B978-1-4160-6127-4.00068-9
1076:10.1016/B978-0-12-802838-4.00033-9
781:organs. This enables the possible
591:. It acts as a blocking agent for
14:
1753:U.S. Food and Drug Administration
1688:U.S. Food and Drug Administration
3176:
1553:The British Journal of Radiology
998:10.1016/j.sempedsurg.2019.150859
829:, vomiting, and abdominal pain.
464:
455:
3199:Adrenergic receptor antagonists
1234:. Cham: Springer. p. 481.
718:, most commonly neuroblastoma,
545:Key:PDWUPXJEEYOOTR-UHFFFAOYSA-N
1547:Ballinger JR (November 2018).
461:
449:
1:
986:Seminars in Pediatric Surgery
1240:10.1007/978-3-319-68873-2_70
1232:Imaging in Clinical Oncology
1122:Ashcraft's pediatric surgery
1070:. London. pp. 467–470.
900:Iobenguane I 131 for cancers
891:10–15 days after injection.
883:guidelines, endorsed by the
806:positron emission tomography
685:Technetium (99mTc) sestamibi
1724:"AZEDRA® (iobenguane I 131"
1390:Journal of Nuclear Medicine
808:(PET). I-MIBG imaging on a
582:adrenergic neurotransmitter
3235:
1301:10.1007/s00259-019-04398-1
867:The dosing regime for the
836:
682:
651:norepinephrine transporter
439:Chemical and physical data
3082:
2703:
1787:National Cancer Institute
1613:10.1007/s00259-008-0715-3
1436:10.1007/s00259-018-4070-8
1352:10.1038/s41536-020-0096-1
1339:npj Regenerative Medicine
1228:"SPECT in Adrenal Glands"
665:Metabolites and excretion
553:
528:
508:
204:1-(3-iodobenzyl)guanidine
192:
26:
3204:Diagnostic endocrinology
853:medullary thyroid cancer
779:autonomically innervated
770:, benign, and malignant
520:C1=CC(=CC(=C1)I)CNC(=N)N
2539:Gallium (Ga) gozetotide
2088:Iodinated human albumin
1661:10.2967/jnmt.115.158394
3214:3-Iodophenyl compounds
1839:Central nervous system
1183:Nucleic Acids Research
1068:Imaging in dermatology
851:, neuroblastomas, and
711:
2473:Fludeoxyglucose (18F)
2400:Pittsburgh compound B
2041:Cardiovascular system
1515:10.3892/etm.2018.5871
754:. When labelled with
714:MIBG concentrates in
693:
3219:Radiopharmaceuticals
2946:Ibritumomab tiuxetan
2855:radiopharmaceuticals
2519:Fluorothymidine F-18
2514:Fluoroestradiol F-18
2433:Desmethoxyfallypride
1940:Sodium iodohippurate
1826:radiopharmaceuticals
1565:10.1259/bjr.20170969
1116:Davidoff AM (2010).
1041:10.1148/rg.272065058
839:Radionuclide therapy
833:Radionuclide therapy
599:, it can be used in
57:-iodobenzylguanidine
2503:Fluorodeoxysorbitol
2247:Fluoroethyltyrosine
2186:Satumomab pendetide
1775:NCI Drug Dictionary
1226:Vlachou FJ (2018).
1195:10.1093/nar/gkx1037
1189:(D1): D1074–D1082.
859:Thyroid precautions
633:Usage and mechanism
589:radiopharmaceutical
23:
2893:Strontium chloride
2584:Piflufolastat F-18
2458:Flotufolastat F-18
2453:Flortaucipir (18F)
2271:Piflufolastat F-18
2242:Fluorodeoxyglucose
2181:Capromab pendetide
2004:Respiratory system
1894:Flutemetamol (18F)
1783:"Iobenguane I 131"
1771:"iobenguane I 131"
1559:(1091): 20170969.
712:
677:Diagnostic imaging
659:synaptic terminals
593:adrenergic neurons
147:) (I, therapeutic)
3164:
3163:
3078:
3077:
2820:
2819:
2699:
2698:
2593:Rubidium chloride
2559:N-Methylspiperone
2448:Florbetapir (18F)
2443:Florbetaben (18F)
2395:N-Methylspiperone
2226:Iobenguane (131I)
2213:Iobenguane (123I)
2078:Rubidium chloride
1890:Florbetapir (18F)
1870:Iofetamine (123I)
1789:. 15 August 2018.
1430:(11): 2009–2024.
1396:(10): 1625–1636.
1294:(10): 2112–2137.
1249:978-3-319-68872-5
1139:978-1-4160-6127-4
1085:978-0-12-802838-4
790:positron-emitting
619:pheochromocytomas
601:nuclear medicinal
571:
570:
499:Interactive image
408:CompTox Dashboard
173:
136:) (I, diagnostic)
76:
16:Chemical compound
3226:
3181:
3180:
3179:
3172:
2975:
2847:
2840:
2833:
2824:
2324:
2223:
2210:
2197:
2169:Hynic-octreotide
1977:Gastrointestinal
1875:Iolopride (123I)
1865:Ioflupane (123I)
1818:
1811:
1804:
1795:
1790:
1778:
1757:
1756:
1745:
1739:
1738:
1736:
1735:
1720:
1714:
1713:
1706:
1700:
1699:
1697:
1695:
1680:
1674:
1673:
1663:
1639:
1633:
1632:
1607:(5): 1039–1047.
1596:
1587:
1586:
1576:
1544:
1538:
1537:
1527:
1517:
1508:(4): 3151–3160.
1493:
1487:
1486:
1462:
1456:
1455:
1415:
1406:
1405:
1381:
1375:
1374:
1364:
1354:
1330:
1324:
1323:
1313:
1303:
1279:
1262:
1261:
1223:
1217:
1216:
1206:
1171:
1169:
1167:
1153:
1147:
1146:
1113:
1107:
1106:
1100:
1092:
1059:
1053:
1052:
1024:
1018:
1017:
981:
975:
974:
972:
970:
955:
949:
948:
946:
944:
929:
877:Lugol's solution
873:potassium iodide
849:carcinoid tumors
724:pheochromocytoma
716:endocrine tumors
695:Pheochromocytoma
639:chromaffin cells
567:
566:
559:
501:
481:
466:
463:
457:
451:
431:
430:
416:
414:
399:
379:
359:
352:
332:
325:
305:
285:
265:
258:
248:
247:
233:
225:
171:
168:
146:
135:
124:
86:
75:
72:
46:Adreview, Azedra
31:
24:
22:
3234:
3233:
3229:
3228:
3227:
3225:
3224:
3223:
3189:
3188:
3187:
3177:
3175:
3167:
3165:
3160:
3159:
3153:
3084:Isotopes used:
3074:
3006:
2991:Radium chloride
2964:
2924:
2898:
2862:
2851:
2821:
2816:
2815:
2809:
2705:Isotopes used:
2695:
2604:
2315:
2307:
2302:Iodocholesterol
2275:
2252:Sodium fluoride
2221:
2208:
2195:
2140:
2093:
2035:
1998:
1971:
1922:
1905:Skeletal system
1899:
1833:
1822:
1781:
1769:
1766:
1761:
1760:
1755:. 30 July 2018.
1747:
1746:
1742:
1733:
1731:
1722:
1721:
1717:
1708:
1707:
1703:
1693:
1691:
1682:
1681:
1677:
1641:
1640:
1636:
1598:
1597:
1590:
1546:
1545:
1541:
1495:
1494:
1490:
1464:
1463:
1459:
1417:
1416:
1409:
1383:
1382:
1378:
1332:
1331:
1327:
1281:
1280:
1265:
1250:
1225:
1224:
1220:
1173:
1165:
1163:
1161:DrugBank Online
1155:
1154:
1150:
1140:
1118:"Neuroblastoma"
1115:
1114:
1110:
1093:
1086:
1061:
1060:
1056:
1026:
1025:
1021:
983:
982:
978:
968:
966:
957:
956:
952:
942:
940:
939:. 10 March 2020
931:
930:
926:
921:
902:
897:
895:Clinical trials
861:
841:
835:
819:
740:salivary glands
736:adrenal medulla
688:
679:
667:
635:
562:
560:
557:(what is this?)
554:
549:
546:
541:
536:
535:
524:
521:
516:
515:
504:
479:
469:
460:
454:
434:
410:
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382:
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288:
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208:
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1029:Radiographics
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1003:
999:
995:
992:(6): 150859.
991:
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977:
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865:
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845:beta emitting
840:
832:
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828:
824:
816:
814:
811:
807:
803:
799:
795:
791:
786:
784:
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773:
769:
765:
761:
760:scintigraphic
757:
753:
749:
745:
741:
737:
733:
729:
725:
721:
720:paraganglioma
717:
708:
704:
700:
696:
692:
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664:
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583:
579:
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478:
476:
472:
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437:
429:
425:
421:
420:
418:
409:
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385:
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264:
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98:
92:
85:
80:
71:
70:
68:
66:
62:
56:
53:
49:
45:
43:
39:
36:Clinical data
34:
30:
25:
3144:strontium-89
3139:samarium-153
3119:lutetium-177
3089:actinium-225
2917:
2853:Therapeutic
2800:thallium-201
2785:samarium-153
2622:scintigraphy
2529:Flutemetamol
2468:Fluciclovine
2237:Fluciclovine
2225:
2212:
2200:Minretumomab
2099:Inflammation
1786:
1774:
1752:
1743:
1732:. Retrieved
1728:the original
1718:
1704:
1692:. Retrieved
1678:
1654:(2): 82–86.
1651:
1647:
1637:
1604:
1600:
1556:
1552:
1542:
1505:
1501:
1491:
1474:
1470:
1460:
1427:
1423:
1393:
1389:
1379:
1342:
1338:
1328:
1291:
1287:
1231:
1221:
1186:
1182:
1164:. Retrieved
1160:
1157:"Iobenguane"
1151:
1143:
1121:
1111:
1089:
1067:
1057:
1032:
1028:
1022:
989:
985:
979:
967:. Retrieved
962:
953:
941:. Retrieved
936:
927:
905:
903:
889:
866:
862:
842:
820:
817:Side effects
810:gamma camera
787:
783:non-invasive
776:
752:neural crest
713:
699:scintigraphy
680:
668:
636:
612:
610:treatments.
608:chemotherapy
597:radiolabeled
577:
573:
572:
561:
555:
161:Legal status
155:Legal status
65:License data
54:
3134:rhenium-186
3094:bismuth-213
2958:Tositumomab
2790:selenium-75
2780:rubidium-82
2770:nitrogen-13
2765:krypton-81m
2730:fluorine-18
2715:chromium-51
2370:Carfentanil
2316:(including
2159:Arcitumomab
2125:Tilmanocept
2115:Exametazime
2058:Tetrofosmin
1851:Exametazime
1824:Diagnostic
823:tachycardia
671:metabolized
482: g·mol
377:CHEBI:92769
188:Identifiers
102:Intravenous
51:Other names
42:Trade names
3209:Guanidines
3193:Categories
3155:See also:
3149:yttrium-90
3129:radium-223
3114:iodine-131
3104:erbium-169
2933:antibodies
2918:Iobenguane
2904:Adrenergic
2882:Lexidronam
2869:palliation
2811:See also:
2760:iodine-131
2755:iodine-125
2750:iodine-123
2745:indium-111
2740:gallium-68
2735:gallium-67
2599:Setoperone
2524:Fluspidine
2509:Fluorodopa
2492:Altanserin
2483:Flumazenil
2438:Fallypride
2405:Raclopride
2390:Methionine
2385:Flumazenil
2356:(Cimbi-36)
1962:Mertiatide
1734:2018-08-03
1175:Wishart DS
919:References
837:See also:
794:iodine-124
756:iodine-123
627:iodine-131
574:Iobenguane
487:3D model (
475:Molar mass
330:P2TH1XYZ84
323:35MRW7B4AD
294:ChemSpider
231:76924-93-1
226:77679-27-7
223:80663-95-2
214:CAS Number
197:IUPAC name
125:) (I)
84:Iobenguane
59:mIBG, MIBG
21:Iobenguane
2805:xenon-133
2775:oxygen-15
2725:copper-64
2720:cobalt-57
2710:carbon-11
2610:gamma ray
2463:Flubatine
2410:Verapamil
2354:25B-NBOMe
2348:ME@HAPTHI
2164:Votumumab
2120:Sulesomab
2103:infection
2068:Imciromab
2053:Sestamibi
1880:Iomazenil
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1097:cite book
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3109:gold-198
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