402:
379:
737:
29:
481:
523:
InChI=1S/C24H21I6N5O8/c1-7(37)35(3)20-17(29)10(21(39)31-2)13(25)11(18(20)30)23(41)33-6-8(38)34-19-15(27)9(22(40)32-4-5-36)14(26)12(16(19)28)24(42)43/h36H,4-6H2,1-3H3,(H,31,39)(H,32,40)(H,33,41)(H,34,38)(H,42,43)
762:/kg water at 37 °C (99 °F), meaning that the solution has a relatively low concentration of molecules; this is usually associated with fewer adverse effects than high-osmolality contrast agents.
663:
and vomiting. All of these are usually mild and transient. Allergy-like effects such as itching, sneezing, coughing and yawning can be the first sign of severe adverse reactions, especially a
91:
880:
612:
51:
495:
811:
Meijenhorst GC, de Bruin JN (August 1980). "Hexabrix (ioxaglate), a new low osmolality contrast agent for lumbar epidural double-catheter venography".
980:
1489:
1305:
515:
557:(relatively few molecules per volume), typically resulting in fewer side effects than high-osmolality media. It is manufactured by
1548:
659:
Adverse effects include reactions at the injection site, such as a hot or painful feeling as well as general reactions such as
196:
121:
1533:
1438:
973:
774:, which is unusually high for a water-soluble iodinated contrast agent. The substance is distributed in the body with a
298:
1506:
358:
671:
561:, but marketing in the US has been discontinued. As of 2021, it may still be available in some European countries.
887:
713:, can be less effective when used within two to six weeks after application of ioxaglic acid because of residual
80:
1494:
1371:
966:
69:
397:
1553:
782:(unchanged) form via the kidneys with a half-life of 92 minutes (range 61 to 140 minutes). In people with
750:
Ioxaglic acid is an iodine-containing, water-soluble radiocontrast agent. The iodine atoms readily absorb
608:
347:
145:
1543:
596:
743:
of a patient with brain metastases from breast cancer, before (left) and after (right) injection of an
1211:
775:
165:
1538:
1475:
1450:
736:
664:
647:
imaging), for hysterosalpingography in women who are pregnant or have an acute inflammation in the
374:
213:
84:
1386:
1287:
836:
744:
731:
546:
1399:
1394:
1335:
944:
828:
41:
1050:
936:
820:
414:
137:
307:
222:
1355:
1206:
1201:
1186:
1176:
1060:
1030:
989:
771:
620:
604:
287:
155:
503:
CC(=O)N(C)C1=C(C(=C(C(=C1I)C(=O)NCC(=O)NC2=C(C(=C(C(=C2I)C(=O)O)I)C(=O)NCCO)I)I)C(=O)NC)I
401:
378:
1500:
1360:
1345:
1310:
1273:
1196:
1166:
1045:
1035:
916:(in German). Vienna: Österreichischer Apothekerverlag. Hexabrix 320 mg Jod/ml-Ampullen.
783:
710:
687:
683:
632:
592:
1527:
1455:
1191:
1171:
1087:
1065:
1055:
1022:
1002:
940:
648:
550:
390:
76:
927:
Krause W, Niehues D (1996). "Biochemical characterization of x-ray contrast media".
840:
770:
After injection into a vein, 14% of the circulating ioxaglic acid is bound to blood
1470:
1464:
1408:
1376:
1340:
1325:
1296:
1252:
993:
706:
675:
584:
104:
99:
247:
1446:
1350:
1320:
1257:
1237:
1095:
779:
740:
644:
640:
580:
1424:
1404:
1330:
1315:
1241:
1181:
1145:
755:
698:
679:
554:
453:
278:
20:
1459:
1135:
1115:
1110:
1070:
787:
616:
588:
568:
178:
55:
28:
948:
866:
832:
61:
1233:
1140:
1130:
1125:
1120:
1040:
258:
267:
1247:
1150:
1100:
1075:
958:
824:
702:
558:
233:
791:
759:
751:
714:
660:
636:
600:
338:
583:(imaging of blood vessels, including those of the brain and heart),
327:
735:
480:
471:
881:"Ioxaglic acid: List of nationally authorised medicinal products"
318:
962:
754:, resulting in a higher contrast of X-ray images. It has a low
363:
778:
of 12 minutes (range 4 to 17 minutes) and eliminated in un
204:
3--2,4,6-triiodo-5-(2-{formamido}acetamido)benzoic acid
1437:
1417:
1385:
1295:
1286:
1266:
1224:
1159:
1084:
1019:
1010:
1001:
678:) can result in life-threatening reactions such as
469:
452:
413:
408:
389:
357:
337:
317:
297:
277:
257:
232:
212:
187:
177:
164:
154:
144:
136:
120:
115:
90:
68:
50:
40:
35:
651:, or for arthrography if the joint is infected.
631:Ioxaglic acid is contraindicated in people with
246:
221:
613:endoscopic retrograde cholangiopancreatography
974:
8:
19:
860:
858:
856:
854:
852:
850:
129:In general: ℞ (Prescription only)
1292:
1016:
1007:
981:
967:
959:
400:
377:
286:
27:
306:
803:
520:
500:
373:
266:
201:
391:
18:
865:
346:
60:
7:
907:
905:
903:
901:
899:
897:
564:It is applied in form of its salts,
545:) is pharmaceutical drug used as an
103:
326:
237:
14:
867:FDA Professional Drug Information
726:Chemistry and mechanism of action
639:content. It must not be used for
62:FDA Professional Drug Information
941:10.1097/00004424-199601000-00006
745:iodine-containing contrast agent
437:
425:
528:Key:TYYBFXNZMFNZJT-UHFFFAOYSA-N
443:
431:
419:
1:
786:, it is eliminated via the
1570:
729:
705:used for thyroid imaging (
672:intrathecal administration
409:Chemical and physical data
1484:
912:Haberfeld H, ed. (2020).
888:European Medicines Agency
511:
491:
192:
26:
1549:Iodobenzene derivatives
1372:Ferric ammonium citrate
870:. Accessed 2021-03-26.
747:
684:cerebral (brain) edema
635:because of the drug's
615:(ERCP; imaging of the
609:gastrointestinal tract
571:and ioxaglate sodium.
739:
730:Further information:
597:hysterosalpingography
587:(imaging of joints),
183:Unchanged via kidneys
1534:Radiocontrast agents
1476:Sulfur hexafluoride
23:
1511:Never to phase III
890:. 31 October 2018.
825:10.1007/bf00346858
748:
732:Iodinated contrast
607:), imaging of the
547:iodinated contrast
1521:
1520:
1433:
1432:
1387:Superparamagnetic
1336:Gadopentetic acid
1282:
1281:
1220:
1219:
709:) and therapy of
627:Contraindications
536:
535:
482:Interactive image
359:CompTox Dashboard
16:Chemical compound
1561:
1469:Microspheres of
1306:Gadolinium-based
1293:
1212:Calcium iopodate
1051:Ioxitalamic acid
1017:
1008:
983:
976:
969:
960:
953:
952:
924:
918:
917:
909:
892:
891:
885:
877:
871:
869:
862:
845:
844:
808:
766:Pharmacokinetics
701:, a radioactive
621:pancreatic ducts
599:(imaging of the
591:(imaging of the
484:
464:
462:
445:
439:
433:
427:
421:
404:
393:
382:
381:
367:
365:
350:
330:
310:
290:
270:
250:
240:
239:
225:
169:
107:
64:
31:
24:
22:
1569:
1568:
1564:
1563:
1562:
1560:
1559:
1558:
1524:
1523:
1522:
1517:
1516:
1501:Clinical trials
1480:
1429:
1413:
1381:
1356:Gadoversetamide
1278:
1262:
1227:Water insoluble
1226:
1216:
1207:Tyropanoic acid
1202:Sodium iopodate
1187:Iobenzamic acid
1177:Ioglycamic acid
1155:
1086:
1080:
1061:Acetrizoic acid
1031:Diatrizoic acid
1021:
1012:
997:
987:
957:
956:
926:
925:
921:
911:
910:
895:
883:
879:
878:
874:
863:
848:
810:
809:
805:
800:
772:plasma proteins
768:
734:
728:
723:
711:thyroid cancers
696:
657:
655:Adverse effects
629:
605:fallopian tubes
577:
532:
529:
524:
519:
518:
507:
504:
499:
498:
487:
460:
458:
448:
442:
436:
430:
424:
385:
361:
353:
333:
313:
293:
273:
253:
236:
228:
208:
205:
200:
199:
167:
146:Protein binding
138:Pharmacokinetic
132:
111:
71:
17:
12:
11:
5:
1567:
1565:
1557:
1556:
1551:
1546:
1541:
1536:
1526:
1525:
1519:
1518:
1515:
1514:
1513:
1512:
1509:
1498:
1492:
1486:
1485:
1482:
1481:
1479:
1478:
1473:
1467:
1462:
1456:Microparticles
1453:
1443:
1441:
1435:
1434:
1431:
1430:
1428:
1427:
1421:
1419:
1415:
1414:
1412:
1411:
1402:
1397:
1391:
1389:
1383:
1382:
1380:
1379:
1374:
1364:
1363:
1361:Gadoxetic acid
1358:
1353:
1348:
1346:Gadoteric acid
1343:
1338:
1333:
1328:
1323:
1318:
1313:
1311:Gadobenic acid
1301:
1299:
1290:
1284:
1283:
1280:
1279:
1277:
1276:
1274:Barium sulfate
1270:
1268:
1264:
1263:
1261:
1260:
1255:
1250:
1245:
1234:Ethiodized oil
1230:
1228:
1222:
1221:
1218:
1217:
1215:
1214:
1209:
1204:
1199:
1197:Iocetamic acid
1194:
1189:
1184:
1179:
1174:
1169:
1167:Iodoxamic acid
1163:
1161:
1157:
1156:
1154:
1153:
1148:
1143:
1138:
1133:
1128:
1123:
1118:
1113:
1108:
1103:
1098:
1092:
1090:
1082:
1081:
1079:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1046:Iotalamic acid
1043:
1038:
1036:Metrizoic acid
1033:
1027:
1025:
1014:
1005:
999:
998:
990:Contrast media
988:
986:
985:
978:
971:
963:
955:
954:
929:Invest. Radiol
919:
893:
872:
846:
813:Neuroradiology
802:
801:
799:
796:
784:kidney failure
767:
764:
727:
724:
722:
719:
695:
692:
688:cerebral bleed
656:
653:
633:hyperthyreosis
628:
625:
593:urinary system
576:
573:
534:
533:
531:
530:
527:
525:
522:
514:
513:
512:
509:
508:
506:
505:
502:
494:
493:
492:
489:
488:
486:
485:
477:
475:
467:
466:
456:
450:
449:
446:
440:
434:
428:
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417:
411:
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395:
387:
386:
384:
383:
370:
368:
355:
354:
352:
351:
343:
341:
335:
334:
332:
331:
323:
321:
315:
314:
312:
311:
303:
301:
295:
294:
292:
291:
283:
281:
275:
274:
272:
271:
263:
261:
255:
254:
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241:
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229:
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226:
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210:
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175:
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162:
161:
158:
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151:
148:
142:
141:
134:
133:
131:
130:
126:
124:
118:
117:
113:
112:
110:
109:
96:
94:
88:
87:
81:intraarticular
74:
72:administration
66:
65:
58:
48:
47:
44:
38:
37:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
1566:
1555:
1554:Benzoic acids
1552:
1550:
1547:
1545:
1542:
1540:
1537:
1535:
1532:
1531:
1529:
1510:
1508:
1505:
1504:
1502:
1499:
1496:
1493:
1491:
1488:
1487:
1483:
1477:
1474:
1472:
1471:phospholipids
1468:
1466:
1463:
1461:
1457:
1454:
1452:
1451:human albumin
1448:
1445:
1444:
1442:
1440:
1436:
1426:
1423:
1422:
1420:
1416:
1410:
1409:nanoparticles
1406:
1403:
1401:
1398:
1396:
1393:
1392:
1390:
1388:
1384:
1378:
1375:
1373:
1369:
1366:
1365:
1362:
1359:
1357:
1354:
1352:
1349:
1347:
1344:
1342:
1339:
1337:
1334:
1332:
1329:
1327:
1324:
1322:
1319:
1317:
1314:
1312:
1308:
1307:
1303:
1302:
1300:
1298:
1294:
1291:
1289:
1285:
1275:
1272:
1271:
1269:
1267:Non-iodinated
1265:
1259:
1256:
1254:
1251:
1249:
1246:
1243:
1239:
1235:
1232:
1231:
1229:
1223:
1213:
1210:
1208:
1205:
1203:
1200:
1198:
1195:
1193:
1192:Iopanoic acid
1190:
1188:
1185:
1183:
1180:
1178:
1175:
1173:
1172:Iotroxic acid
1170:
1168:
1165:
1164:
1162:
1158:
1152:
1149:
1147:
1144:
1142:
1139:
1137:
1134:
1132:
1129:
1127:
1124:
1122:
1119:
1117:
1114:
1112:
1109:
1107:
1106:Ioxaglic acid
1104:
1102:
1099:
1097:
1094:
1093:
1091:
1089:
1085:Nephrotropic,
1083:
1077:
1074:
1072:
1069:
1067:
1066:Iocarmic acid
1064:
1062:
1059:
1057:
1056:Ioglicic acid
1054:
1052:
1049:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1028:
1026:
1024:
1020:Nephrotropic,
1018:
1015:
1013:Water soluble
1009:
1006:
1004:
1000:
995:
991:
984:
979:
977:
972:
970:
965:
964:
961:
950:
946:
942:
938:
934:
930:
923:
920:
915:
914:Austria-Codex
908:
906:
904:
902:
900:
898:
894:
889:
882:
876:
873:
868:
861:
859:
857:
855:
853:
851:
847:
842:
838:
834:
830:
826:
822:
818:
814:
807:
804:
797:
795:
793:
789:
785:
781:
777:
773:
765:
763:
761:
758:of 600
757:
753:
746:
742:
738:
733:
725:
720:
718:
717:in the body.
716:
712:
708:
704:
700:
693:
691:
689:
685:
681:
677:
673:
668:
666:
662:
654:
652:
650:
649:pelvic region
646:
642:
638:
634:
626:
624:
622:
618:
614:
610:
606:
602:
598:
594:
590:
586:
582:
579:Uses include
574:
572:
570:
567:
562:
560:
556:
553:. It has low
552:
551:X-ray imaging
548:
544:
540:
539:Ioxaglic acid
526:
521:
517:
510:
501:
497:
490:
483:
479:
478:
476:
473:
468:
457:
455:
451:
418:
416:
412:
407:
403:
399:
396:
394:
392:ECHA InfoCard
388:
380:
376:
375:DTXSID5023166
372:
371:
369:
360:
356:
349:
348:ChEMBL1201291
345:
344:
342:
340:
336:
329:
325:
324:
322:
320:
316:
309:
305:
304:
302:
300:
296:
289:
285:
284:
282:
280:
276:
269:
265:
264:
262:
260:
256:
249:
245:
244:
242:
235:
231:
224:
220:
219:
217:
215:
211:
202:
198:
191:
186:
182:
180:
176:
172:
170:
163:
159:
157:
153:
149:
147:
143:
139:
135:
128:
127:
125:
123:
119:
114:
106:
101:
98:
97:
95:
93:
89:
86:
82:
78:
77:Intravascular
75:
73:
67:
63:
59:
57:
53:
49:
45:
43:
39:
36:Clinical data
34:
30:
25:
21:Ioxaglic acid
1544:Acetanilides
1465:Perflenapent
1447:Microspheres
1377:Mangafodipir
1367:
1341:Gadopiclenol
1326:Gadofosveset
1304:
1297:Paramagnetic
1253:Propyliodone
1238:Ethyl esters
1160:Hepatotropic
1105:
1023:high osmolar
1003:X-ray and CT
935:(1): 30–42.
932:
928:
922:
913:
875:
819:(1): 29–32.
816:
812:
806:
769:
749:
721:Pharmacology
707:scintigraphy
697:
694:Interactions
676:spinal canal
669:
658:
630:
585:arthrography
578:
575:Medical uses
565:
563:
542:
541:(trade name
538:
537:
166:Elimination
122:Legal status
116:Legal status
1497:from market
1351:Gadoteridol
1321:Gadodiamide
1258:Iofendylate
1244:, lipiodol)
1242:fatty acids
1240:of iodised
1096:Metrizamide
1088:low osmolar
780:metabolized
741:Contrast CT
680:convulsions
670:Accidental
645:spinal cord
641:myelography
581:angiography
549:medium for
465: g·mol
398:100.055.945
188:Identifiers
42:Trade names
1539:Benzamides
1528:Categories
1439:Ultrasound
1425:Perflubron
1405:Iron oxide
1400:Ferristene
1395:Ferumoxsil
1331:Gadolinium
1316:Gadobutrol
1225:Iodinated,
1182:Adipiodone
1146:Iobitridol
1011:Iodinated,
798:References
794:or sweat.
756:osmolality
699:Iodine-131
674:(into the
555:osmolality
470:3D model (
454:Molar mass
308:Z40X7EI2AF
279:ChemSpider
223:59017-64-0
214:CAS Number
197:IUPAC name
156:Metabolism
1507:Phase III
1495:Withdrawn
1460:galactose
1136:Iodixanol
1116:Iopromide
1111:Iopamidol
1071:Methiodal
864:Hexabrix
788:bile duct
776:half-life
589:urography
569:meglumine
566:ioxaglate
179:Excretion
168:half-life
70:Routes of
56:Drugs.com
1141:Iomeprol
1131:Iopentol
1126:Ioversol
1121:Iotrolan
1041:Iodamide
841:39778683
543:Hexabrix
259:DrugBank
92:ATC code
85:by mouth
46:Hexabrix
1248:Iopydol
1151:Ioxilan
1101:Iohexol
1076:Diodone
949:8850363
833:6999377
703:isotope
617:biliary
559:Guerbet
415:Formula
268:DB09313
234:PubChem
108:)
102: (
100:V08AB03
1490:WHO-EM
947:
839:
831:
792:saliva
752:X-rays
715:iodine
661:nausea
637:iodine
611:, and
601:uterus
496:SMILES
339:ChEMBL
328:D01761
173:92 min
1418:Other
1368:Other
884:(PDF)
837:S2CID
665:shock
516:InChI
472:JSmol
945:PMID
829:PMID
760:mosm
619:and
603:and
463:.886
319:KEGG
299:UNII
288:3611
248:3742
160:None
140:data
52:AHFS
1458:of
1449:of
1288:MRI
1236:(=
994:V08
937:doi
821:doi
686:or
623:).
595:),
461:268
364:EPA
238:CID
150:14%
105:WHO
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933:31
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896:^
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817:20
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474:)
459:1
447:8
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441:5
438:N
435:6
432:I
426:H
420:C
366:)
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54:/
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