622:
599:
42:
955:
51:
1596:
853:
3357:
3345:
1061:. This statistically significant difference in viral load reduction has caused some HIV researchers to begin questioning long held paradigms about HIV viral dynamics and decay. Research into raltegravir's ability to affect latent viral reservoirs and possibly aid in the eradication of HIV is currently ongoing.
875:
regimens for adults and children use these cocktails). Raltegravir is available in chewable form, but because the two tablet formulations are not interchangeable, the chewable pills are only approved for use in children two to 11. Older adolescents will use the adult formulation.
1356:
2348:
1690:
Summa V, Petrocchi A, Bonelli F, Crescenzi B, Donghi M, Ferrara M, et al. (September 2008). "Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection".
1113:
868:(FDA) granted expanded approval for raltegravir for use in all patients. As with any HAART medication, raltegravir is unlikely to show durability if used as monotherapy, due to the highly mutagenic nature of HIV.
1040:
authorised the first generic raltegravir medicines for adult and paediatric patients with HIV who weigh at least 40kg. Authorisation was granted to Lupin
Healthcare (UK) Limited and Zentiva Pharma UK Limited.
1372:"Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study"
912:
Raltegravir was generally well tolerated when used in combination with optimized background therapy regimens in treatment-experienced patients with HIV-1 infection in trials of up to 48 weeks' duration.
694:
1053:
and decay and further research in this area is ongoing. In clinical trials patients taking raltegravir achieved viral loads less than 50 copies per millitre sooner than those taking similarly potent
871:
In
December 2011, it approval for use in children over the age of two, taken in pill form orally twice a day by prescription with two other antiretroviral medications to form the cocktail (most
2532:
2537:
1070:
on July 24, 2008. The authors concluded that "raltegravir plus optimized background therapy provided better viral suppression than optimized background therapy alone for at least 48 weeks."
2483:
1594:, Gurjar MK, Sonawane SP, Maikap GS, Patil GD, Shinde SB, Patil PS Mehta SS, "Synthesis of raltegravir", published 2013-07-04, assigned to Emcure Pharmaceuticals Ltd
3407:
1955:
2922:
183:
2119:
1610:
1037:
1022:
2489:
2547:
2467:
2552:
2500:
1901:
81:
2522:
2506:
1614:
1317:
708:
736:
InChI=1S/C20H21FN6O5/c1-10-25-26-17(32-10)16(30)24-20(2,3)19-23-13(14(28)18(31)27(19)4)15(29)22-9-11-5-7-12(21)8-6-11/h5-8,28H,9H2,1-4H3,(H,22,29)(H,24,30)
2517:
3382:
2527:
2794:
2438:
814:
892:
levels below detection at a more rapid rate. After 24 and 48 weeks of treatment, raltegravir did not result in increased serum levels of total
3318:
3304:
3284:
2961:
2893:
2784:
1567:
1532:
1231:
829:
884:
In a study of the drug as part of combination therapy, raltegravir exhibited potent and durable antiretroviral activity similar to that of
1454:
Croxtall JD, Keam SJ (May 2009). "Raltegravir: a review of its use in the management of HIV infection in treatment-experienced patients".
2542:
1726:
2984:
2557:
1773:
for "Impact of MK-0518 (Raltegravir) Intensification on HIV-1 Viral
Latency in Patients With Previous Complete Viral Suppression" at
1618:
3402:
2113:
1894:
1058:
728:
1167:"Isentress- raltegravir tablet, film coated Isentress- raltegravir tablet, chewable Isentress- raltegravir granule, for suspension"
2567:
2451:
1166:
2577:
2562:
2342:
2322:
2240:
2225:
2213:
1870:
1066:
1054:
986:
340:
213:
113:
2457:
3377:
1879:
794:
1887:
865:
442:
132:
3267:
2910:
1419:
Stephenson J (April 2007). "Researchers buoyed by novel HIV drugs: will expand drug arsenal against resistant virus".
1006:
578:
3335:
2954:
1282:
1196:
771:
759:
2734:
2644:
2512:
2473:
1084:
In
January 2013, a Phase II trial was initiated to evaluate the therapeutic benefit of raltegravir in treating
1313:
860:
Raltegravir was initially approved only for use in individuals whose infection has proven resistant to other
3311:
2994:
2898:
2494:
897:
169:
1847:"Raltegravir (Isentress) Pilot Study in Relapsing Multiple Sclerosis - Full Text View - ClinicalTrials.gov"
1093:
617:
3050:
2572:
837:
833:
289:
1591:
519:
3392:
3207:
3101:
3055:
2769:
2582:
2462:
2332:
1931:
1089:
1074:
348:
N-(4-Fluorobenzyl)-5-hydroxy-1-methyl-2-(2-{amino}-2-propanyl)-6-oxo-1,6-dihydro-4-pyrimidinecarboxamide
3397:
3387:
2947:
2478:
2327:
2085:
309:
1750:
3029:
2587:
2446:
2318:
2236:
2035:
1914:
922:
872:
594:
357:
176:
3014:
539:
3232:
3156:
1827:
1774:
1573:
1479:
1401:
1370:
Markowitz M, Nguyen BY, Gotuzzo E, Mendo F, Ratanasuwan W, Kovacs C, et al. (October 2007).
1085:
790:
143:
1786:
Steigbigel RT, Cooper DA, Kumar PN, Eron JE, Schechter M, Markowitz M, et al. (July 2008).
2875:
2870:
560:
3291:
2999:
2729:
2392:
1809:
1708:
1672:
1563:
1528:
1471:
1436:
1393:
1227:
1191:
822:
550:
499:
431:
252:
239:
227:
63:
1260:
91:
3045:
3004:
2754:
1799:
1700:
1662:
1652:
1553:
1520:
1463:
1428:
1383:
1290:
1010:
970:
782:
634:
366:
271:
1077:(HCMV) terminase proteins demonstrated that raltegravir may block viral replication of the
961:
In one method used for its manufacture, 2-amino-2-methylpropanenitrile is reacted with the
451:
3349:
3192:
3081:
3060:
2830:
2789:
1949:
1874:
938:
299:
279:
1515:
Hunt JA (2010). "Raltegravir (Isentress): The First-in-Class HIV-1 Integrase
Inhibitor".
1338:
621:
598:
3361:
3247:
2989:
2970:
2904:
2680:
2662:
2625:
1910:
1667:
1640:
1558:
1050:
1026:
802:
798:
954:
41:
3371:
3197:
3111:
3024:
2670:
2420:
2255:
2141:
1483:
1467:
1141:
1118:
1078:
974:
962:
901:
818:
810:
610:
391:
105:
1867:
1577:
828:
Raltegravir was approved for medical use in the United States in 2007. It is on the
50:
3237:
3136:
3019:
3009:
2724:
2714:
2295:
2285:
2103:
2060:
2055:
2050:
2012:
1992:
1922:
1405:
530:
196:
191:
1846:
1769:
1142:"Isentress 400 mg Film-coated Tablets - Summary of Product Characteristics (SmPC)"
1787:
1388:
1371:
3297:
3212:
3166:
3161:
3146:
3131:
3106:
2850:
2825:
2764:
2749:
2744:
2408:
2375:
2290:
2270:
2045:
2024:
1971:
1939:
1002:
998:
934:
893:
852:
99:
1497:
937:, a critical step in the HIV infection model. The drug is metabolized away via
774:, to prevent HIV infection following potential exposure. It is taken by mouth.
3227:
3222:
3217:
3176:
3171:
3126:
3086:
3065:
2855:
2835:
2820:
2815:
2779:
2774:
2688:
2633:
2603:
2415:
2403:
2398:
2370:
2310:
2300:
2275:
2260:
2250:
2199:
2194:
2182:
2166:
2156:
2136:
2098:
2008:
1996:
1988:
1524:
1025:
to receive approval in the United States in
October 2007. It was developed by
982:
966:
841:
763:
670:
422:
1788:"Raltegravir with optimized background therapy for resistant HIV-1 infection"
1432:
933:
common to retroviruses that integrates the viral genetic material into human
3202:
3151:
3116:
3096:
3091:
2939:
2865:
2845:
2840:
2810:
2739:
2719:
2652:
2608:
2365:
2280:
2265:
2188:
2161:
2151:
2146:
2093:
2070:
1983:
978:
949:
Raltegravir has been synthesized in several ways, which have been reviewed.
926:
885:
806:
322:
85:
33:
1813:
1712:
1676:
1657:
1475:
1440:
1397:
1287:
World Health
Organization model list of essential medicines: 21st list 2019
1096:, which have been suggested in the pathogenesis of relapsing-remitting MS.
1804:
3242:
3121:
2860:
2245:
786:
767:
402:
127:
17:
1295:
411:
2928:
2759:
2305:
2075:
377:
3356:
1704:
2709:
2704:
930:
778:
510:
1013:
so that methylation occurs on the nitrogen atom of the pyrimidone.
989:. The synthesis is completed by conversion of the remaining methyl
479:
471:
2019:
994:
990:
861:
851:
693:
684:
566:
490:
716:
Cc1nnc(o1)C(=O)NC(C)(C)C\3=N\C(C(=O)NCc2ccc(F)cc2)=C(\O)C(=O)N/3C
1978:
1966:
985:
ring of the drug is then created when the amidoxime reacts with
462:
258:
233:
2943:
1883:
1226:(69 ed.). British Medical Association. 2015. p. 429.
246:
122:
2003:
1918:
889:
777:
Common side effects include trouble sleeping, feeling tired,
1339:"UPDATE 2-FDA OKs widened use of Merck's Isentress HIV drug"
583:
2533:
Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide
154:
2538:
Elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil
1828:"Drug against AIDS could be effective against herpesvirus"
2484:
Darunavir/cobicistat/emtricitabine/tenofovir alafenamide
1299:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
222:
830:
1308:
1306:
3333:
965:
of 5-methyl-1,3,4-oxadiazole-2-carboxylic acid using
1548:
Vardanyan R, Hruby V (2016). "34: Antiviral Drugs".
3276:
3260:
3185:
3074:
3038:
2977:
2803:
2697:
2679:
2661:
2643:
2624:
2617:
2596:
2437:
2384:
2358:
2341:
2224:
2212:
2175:
2129:
2112:
2084:
2034:
1948:
1930:
1641:"Molecular dynamics simulations and drug discovery"
1263:. The American Society of Health-System Pharmacists
1038:
Medicines and
Healthcare products Regulatory Agency
682:
669:
633:
628:
609:
577:
549:
529:
509:
489:
461:
441:
421:
401:
376:
356:
331:
321:
308:
298:
288:
278:
270:
212:
207:
182:
168:
142:
112:
98:
80:
72:
62:
57:
2490:Dolutegravir/emtricitabine/tenofovir alafenamide
1357:"FDA Okays Raltegravir for Kids, Teens with HIV"
390:
2548:Emtricitabine/rilpivirine/tenofovir alafenamide
2468:Bictegravir/emtricitabine/tenofovir alafenamide
1376:Journal of Acquired Immune Deficiency Syndromes
1055:non-nucleoside reverse transcriptase inhibitors
365:
2553:Emtricitabine/rilpivirine/tenofovir disoproxil
2039:(Integrase strand transfer inhibitors (INSTI))
3408:World Health Organization essential medicines
2955:
2501:Dolutegravir/lamivudine/tenofovir alafenamide
1895:
8:
2523:Efavirenz/emtricitabine/tenofovir disoproxil
2507:Dolutegravir/lamivudine/tenofovir disoproxil
1727:"Generic HIV raltegravir medicines approved"
538:
131:
32:
1009:. Use of that reagent ensures the required
3182:
2962:
2948:
2940:
2621:
2518:Doravirine/lamivudine/tenofovir disoproxil
2355:
2221:
2126:
1902:
1888:
1880:
1498:"HIV Antiretroviral Agents in Development"
1255:
1253:
1251:
1249:
1247:
1245:
1243:
620:
597:
430:
2528:Efavirenz/lamivudine/tenofovir disoproxil
1803:
1666:
1656:
1611:"FDA approval of Isentress (raltegravir)"
1557:
1387:
1294:
450:
2795:Zinc finger protein transcription factor
1868:World patent covering the potassium salt
1639:Durrant JD, McCammon JA (October 2011).
1224:British national formulary : BNF 69
1114:"Product monograph brand safety updates"
1033:in the Journal of Medicinal Chemistry.
864:drugs. However, in July 2009, the U.S.
3340:
1218:
1216:
1105:
1064:Research results were published in the
815:HIV integrase strand transfer inhibitor
733:
713:
593:
410:
345:
104:
973:. The product is treated with aqueous
888:at 24 and 48 weeks but achieved HIV-1
611:
31:
3285:Merck Manual of Diagnosis and Therapy
1751:"Faster Viral Decay With Raltegravir"
1289:. Geneva: World Health Organization.
1049:Raltegravir significantly alters HIV
559:
518:
498:
90:
7:
1617:(FDA). June 25, 2009. Archived from
565:
195:
2543:Emtricitabine/tenofovir alafenamide
1792:The New England Journal of Medicine
478:
470:
381:
3383:Drugs developed by Merck & Co.
2558:Emtricitabine/tenofovir disoproxil
1559:10.1016/B978-0-12-411492-0.00034-1
789:. Severe side effects may include
770:. It may also be used, as part of
25:
1615:U.S. Food and Drug Administration
1318:U.S. Food and Drug Administration
1314:"Isentress Drug Approval Package"
1088:(MS). The drug is active against
3355:
3343:
2931:. Formerly or rarely used agent.
2568:Lamivudine/nevirapine/zidovudine
2452:Abacavir/dolutegravir/lamivudine
1468:10.2165/00003495-200969080-00007
953:
817:which blocks the functioning of
654:
651:
645:
49:
40:
2735:Epigallocatechin gallate (EGCG)
2578:Lamivudine/tenofovir disoproxil
2563:Lamivudine/nevirapine/stavudine
1067:New England Journal of Medicine
987:dimethyl acetylenedicarboxylate
741:Key:CZFFBEXEKNGXKS-UHFFFAOYSA-N
2458:Abacavir/lamivudine/zidovudine
1731:European Pharmaceutical Review
1693:Journal of Medicinal Chemistry
1550:Synthesis of Best-Seller Drugs
805:. It is unclear if use during
660:
639:
1:
1090:Human Endogenous Retroviruses
1845:Giovannoni G (24 May 2017).
1389:10.1097/QAI.0b013e318157131c
866:Food and Drug Administration
754:, sold under the brand name
3268:Merck Headquarters Building
2333:Tenofovir alafenamide (TAF)
1007:trimethylsulfoxonium iodide
813:is safe. Raltegravir is an
3424:
2328:Tenofovir disoproxil (TDF)
1021:Raltegravir was the first
993:of the intermediate to an
762:used, together with other
629:Chemical and physical data
2888:
2349:Discovery and development
2120:Discovery and development
1956:Discovery and development
1525:10.1002/9780470768594.ch1
1283:World Health Organization
1197:European Medicines Agency
772:post exposure prophylaxis
760:antiretroviral medication
724:
704:
336:
48:
39:
3403:4-Fluorophenyl compounds
2645:Transcription inhibitors
2597:Pharmacokinetic boosters
2513:Dolutegravir/rilpivirine
2474:Cabotegravir/rilpivirine
2114:Protease Inhibitors (PI)
1592:WO patent 2013098854
1433:10.1001/jama.297.14.1535
1320:(FDA). February 22, 2008
795:Stevens–Johnson syndrome
2929:initial regimen options
2495:Dolutegravir/lamivudine
1972:Enfuvirtide (ENF, T-20)
1950:Entry/fusion inhibitors
1261:"Raltegravir Potassium"
1036:In July 2024, the UK's
898:low-density lipoprotein
3051:Cubist Pharmaceuticals
2770:Portmanteau inhibitors
2663:Translation inhibitors
2573:Lamivudine/raltegravir
2343:Non-nucleoside (NNRTI)
2301:Islatravir (EFdA, ISL)
1767:Clinical trial number
1658:10.1186/1741-7007-9-71
1029:and reported by Summa
925:, raltegravir targets
857:
834:Lamivudine/raltegravir
3208:Ezetimibe/simvastatin
3102:Ezetimibe/simvastatin
3056:H. K. Mulford Company
2971:Merck & Co., Inc.
2785:Synergistic enhancers
2583:Lamivudine/zidovudine
2463:Atazanavir/cobicistat
2439:Combined formulations
2276:Zidovudine (AZT, ZDV)
2214:Reverse-transcriptase
2086:Maturation inhibitors
1805:10.1056/NEJMoa0708975
1517:Modern Drug Synthesis
1092:(HERVs) and possibly
1075:human cytomegalovirus
855:
844:, is also available.
3378:Integrase inhibitors
2626:Uncoating inhibitors
2479:Darunavir/cobicistat
2319:Nucleotide analogues
2237:Nucleoside analogues
2036:Integrase inhibitors
1915:antiretroviral drugs
1552:. pp. 719–720.
821:which is needed for
2978:Corporate directors
2618:Experimental agents
2588:Lopinavir/ritonavir
2447:Abacavir/lamivudine
2421:Elsulfavirine (ESV)
2256:Emtricitabine (FTC)
2142:Fosamprenavir (FPV)
1201:. 17 September 2018
1059:protease inhibitors
1023:integrase inhibitor
923:integrase inhibitor
917:Mechanism of action
242:(Prescription only)
36:
3233:Rocuronium bromide
3157:rVSV-ZEBOV vaccine
2915:Never to phase III
2061:Elvitegravir (EVG)
2056:Dolutegravir (DTG)
2051:Cabotegravir (CAB)
1873:2007-10-14 at the
1851:clinicaltrials.gov
1775:ClinicalTrials.gov
1755:www.thebodypro.com
1094:Epstein–Barr virus
1086:multiple sclerosis
967:N-methylmorpholine
858:
791:allergic reactions
3331:
3330:
3292:The Merck Manuals
3256:
3255:
2937:
2936:
2884:
2883:
2730:Diarylpyrimidines
2433:
2432:
2429:
2428:
2409:Rilpivirine (RPV)
2393:diarylpyrimidines
2376:Delavirdine (DLV)
2271:Zalcitabine (ddC)
2228:nucleotide (NRTI)
2208:
2207:
2066:Raltegravir (RAL)
2046:Bictegravir (BIC)
2025:Fostemsavir (FTR)
1940:Lenacapavir (LEN)
1932:Capsid inhibitors
1705:10.1021/jm800245z
1699:(18): 5843–5855.
1569:978-0-12-411492-0
1534:978-0-470-76859-4
1519:. pp. 1–15.
1427:(14): 1535–1536.
1233:978-0-85711-156-2
856:Isentress tablets
823:viral replication
749:
748:
695:Interactive image
579:CompTox Dashboard
262:
250:
237:
225:
158:
125:
27:Chemical compound
16:(Redirected from
3415:
3360:
3359:
3348:
3347:
3346:
3339:
3183:
3046:Acceleron Pharma
3005:Rochelle Lazarus
2995:William Harrison
2964:
2957:
2950:
2941:
2755:Hydroxycarbamide
2622:
2416:Doravirine (DOR)
2404:Etravirine (ETR)
2399:Dapivirine (DPV)
2371:Nevirapine (NVP)
2356:
2261:Lamivudine (3TC)
2251:Didanosine (ddI)
2222:
2195:Tipranavir (TPV)
2183:Atazanavir (ATV)
2167:Saquinavir (SQV)
2157:Nelfinavir (NFV)
2137:Amprenavir (APV)
2127:
2009:Ibalizumab (IBA)
1904:
1897:
1890:
1881:
1855:
1854:
1842:
1836:
1835:
1824:
1818:
1817:
1807:
1783:
1777:
1765:
1759:
1758:
1747:
1741:
1740:
1738:
1737:
1723:
1717:
1716:
1687:
1681:
1680:
1670:
1660:
1636:
1630:
1629:
1627:
1626:
1621:on July 10, 2009
1607:
1601:
1600:
1599:
1595:
1588:
1582:
1581:
1561:
1545:
1539:
1538:
1512:
1506:
1505:
1504:. 30 March 2006.
1494:
1488:
1487:
1462:(8): 1059–1075.
1451:
1445:
1444:
1416:
1410:
1409:
1391:
1367:
1361:
1360:
1353:
1347:
1346:
1335:
1329:
1328:
1326:
1325:
1310:
1301:
1300:
1298:
1279:
1273:
1272:
1270:
1268:
1257:
1238:
1237:
1220:
1211:
1210:
1208:
1206:
1192:"Isentress EPAR"
1188:
1182:
1181:
1179:
1177:
1163:
1157:
1156:
1154:
1152:
1138:
1132:
1131:
1129:
1127:
1110:
1011:chemoselectivity
957:
900:cholesterol, or
799:muscle breakdown
783:high blood sugar
697:
677:
662:
656:
653:
647:
641:
624:
613:
602:
601:
587:
585:
569:
563:
542:
522:
502:
482:
474:
454:
434:
414:
394:
384:
383:
369:
313:
260:
257:
248:
245:
235:
232:
224:
221:
199:
156:
153:
135:
124:
121:
108:
94:
53:
44:
37:
35:
21:
3423:
3422:
3418:
3417:
3416:
3414:
3413:
3412:
3368:
3367:
3366:
3354:
3344:
3342:
3334:
3332:
3327:
3272:
3252:
3193:Coppertone sign
3186:Schering-Plough
3181:
3070:
3061:Schering-Plough
3034:
2973:
2968:
2938:
2933:
2932:
2920:
2905:Clinical trials
2880:
2831:Dexelvucitabine
2799:
2790:Tre recombinase
2693:
2675:
2657:
2653:Tat antagonists
2639:
2613:
2592:
2425:
2380:
2366:Efavirenz (EFV)
2345:
2337:
2266:Stavudine (d4T)
2227:
2215:
2204:
2189:Darunavir (DRV)
2171:
2162:Ritonavir (RTV)
2152:Lopinavir (LPV)
2147:Indinavir (IDV)
2116:
2108:
2080:
2038:
2030:
1984:Maraviroc (MVC)
1952:
1944:
1926:
1911:Antiviral drugs
1908:
1875:Wayback Machine
1864:
1859:
1858:
1844:
1843:
1839:
1826:
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1821:
1785:
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1762:
1757:. 24 July 2007.
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1514:
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1509:
1502:www.thebody.com
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1139:
1135:
1125:
1123:
1112:
1111:
1107:
1102:
1047:
1019:
947:
939:glucuronidation
919:
910:
882:
850:
745:
742:
737:
732:
731:
720:
717:
712:
711:
700:
675:
665:
659:
650:
644:
605:
581:
573:
545:
525:
505:
485:
457:
437:
417:
397:
380:
372:
352:
349:
344:
343:
327:feces and urine
311:
290:Protein binding
280:Bioavailability
272:Pharmacokinetic
266:
203:
171:
164:
145:
138:
28:
23:
22:
15:
12:
11:
5:
3421:
3419:
3411:
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3258:
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3248:Urofollitropin
3245:
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3205:
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3195:
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3022:
3017:
3012:
3007:
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3000:William Kelley
2997:
2992:
2990:Johnnetta Cole
2987:
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2649:
2647:
2641:
2640:
2638:
2637:
2630:
2628:
2619:
2615:
2614:
2612:
2611:
2606:
2604:Cobicistat (c)
2600:
2598:
2594:
2593:
2591:
2590:
2585:
2580:
2575:
2570:
2565:
2560:
2555:
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2298:
2293:
2288:
2283:
2278:
2273:
2268:
2263:
2258:
2253:
2248:
2246:Abacavir (ABC)
2232:
2230:
2226:Nucleoside and
2219:
2210:
2209:
2206:
2205:
2203:
2202:
2197:
2192:
2186:
2179:
2177:
2173:
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2159:
2154:
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2110:
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2063:
2058:
2053:
2048:
2042:
2040:
2032:
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2029:
2028:
2016:
2000:
1986:
1975:
1962:
1960:
1946:
1945:
1943:
1942:
1936:
1934:
1928:
1927:
1909:
1907:
1906:
1899:
1892:
1884:
1878:
1877:
1863:
1862:External links
1860:
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1856:
1837:
1819:
1798:(4): 339–354.
1778:
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1631:
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1583:
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1507:
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1411:
1382:(2): 125–133.
1362:
1348:
1330:
1302:
1274:
1239:
1232:
1212:
1183:
1158:
1133:
1104:
1103:
1101:
1098:
1051:viral dynamics
1046:
1043:
1018:
1015:
1001:, followed by
981:. The central
959:
958:
946:
943:
918:
915:
909:
906:
881:
878:
873:anti-HIV drugs
849:
846:
803:liver problems
747:
746:
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304:Liver (UGT1A1)
302:
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26:
24:
14:
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2:
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3226:
3224:
3221:
3219:
3216:
3214:
3211:
3209:
3206:
3204:
3201:
3199:
3198:Desloratadine
3196:
3194:
3191:
3190:
3188:
3184:
3178:
3175:
3173:
3170:
3168:
3165:
3163:
3160:
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3153:
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3140:
3138:
3135:
3133:
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3125:
3123:
3120:
3118:
3115:
3113:
3112:Fosaprepitant
3110:
3108:
3105:
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3044:
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3041:
3037:
3031:
3030:Peter Wendell
3028:
3026:
3025:Wendell Weeks
3023:
3021:
3018:
3016:
3013:
3011:
3008:
3006:
3003:
3001:
2998:
2996:
2993:
2991:
2988:
2986:
2985:Richard Clark
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2829:
2827:
2824:
2822:
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2817:
2814:
2812:
2809:
2808:
2806:
2804:Failed agents
2802:
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2783:
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2776:
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2703:
2702:
2700:
2696:
2690:
2687:
2686:
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2672:
2671:Trichosanthin
2669:
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2650:
2648:
2646:
2642:
2635:
2632:
2631:
2629:
2627:
2623:
2620:
2616:
2610:
2609:Ritonavir (r)
2607:
2605:
2602:
2601:
2599:
2595:
2589:
2586:
2584:
2581:
2579:
2576:
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2505:
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2414:
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2407:
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2400:
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2302:
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2229:
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2220:
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2184:
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2165:
2163:
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2148:
2145:
2143:
2140:
2138:
2135:
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2128:
2125:
2123:
2121:
2115:
2111:
2105:
2102:
2100:
2097:
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2072:
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2052:
2049:
2047:
2044:
2043:
2041:
2037:
2033:
2026:
2022:
2021:
2017:
2014:
2010:
2006:
2005:
2001:
1998:
1994:
1990:
1987:
1985:
1981:
1980:
1976:
1973:
1969:
1968:
1964:
1963:
1961:
1959:
1957:
1951:
1947:
1941:
1938:
1937:
1935:
1933:
1929:
1924:
1920:
1917:used against
1916:
1912:
1905:
1900:
1898:
1893:
1891:
1886:
1885:
1882:
1876:
1872:
1869:
1866:
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1806:
1801:
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1536:
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1415:
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1407:
1403:
1399:
1395:
1390:
1385:
1381:
1377:
1373:
1366:
1363:
1358:
1352:
1349:
1345:. 2009-07-10.
1344:
1340:
1334:
1331:
1319:
1315:
1309:
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1303:
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1159:
1147:
1143:
1137:
1134:
1122:. 7 July 2016
1121:
1120:
1119:Health Canada
1115:
1109:
1106:
1099:
1097:
1095:
1091:
1087:
1082:
1080:
1079:herpesviruses
1076:
1071:
1069:
1068:
1062:
1060:
1056:
1052:
1044:
1042:
1039:
1034:
1032:
1028:
1024:
1016:
1014:
1012:
1008:
1004:
1000:
997:with 4-fluoro
996:
992:
988:
984:
980:
976:
975:hydroxylamine
972:
968:
964:
963:acid chloride
956:
952:
951:
950:
944:
942:
940:
936:
932:
928:
924:
916:
914:
907:
905:
903:
902:triglycerides
899:
895:
891:
887:
879:
877:
874:
869:
867:
863:
854:
847:
845:
843:
839:
835:
831:
826:
824:
820:
819:HIV integrase
816:
812:
811:breastfeeding
808:
804:
800:
796:
792:
788:
784:
780:
775:
773:
769:
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674:
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668:
638:
636:
632:
627:
623:
619:
616:
614:
612:ECHA InfoCard
608:
600:
596:
595:DTXSID2048660
592:
591:
589:
580:
576:
568:
567:RCSB PDB
562:
557:
556:
554:
552:
548:
541:
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528:
521:
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316:
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307:
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297:
293:
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283:
281:
277:
273:
269:
263: Rx-only
256:
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107:
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97:
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83:
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75:
71:
67:
65:
61:
58:Clinical data
56:
52:
47:
43:
38:
30:
19:
3393:Carboxamides
3319:
3312:
3305:
3298:
3290:
3283:
3277:Publications
3238:Temozolomide
3141:
3137:Omarigliptin
3039:Subsidiaries
3020:Samuel Thier
3015:Anne Tatlock
3010:Thomas Shenk
2925:
2725:Cyanovirin-N
2715:Calanolide A
2391:
2385:2 generation
2359:1 generation
2346:
2317:
2296:Elvucitabine
2286:Apricitabine
2235:
2176:2 generation
2130:1 generation
2117:
2104:Fipravirimat
2065:
2018:
2013:Semzuvolimab
2002:
1993:Cenicriviroc
1977:
1965:
1953:
1850:
1840:
1832:ScienceDaily
1831:
1822:
1795:
1791:
1781:
1768:
1763:
1754:
1745:
1734:. Retrieved
1730:
1721:
1696:
1692:
1685:
1648:
1644:
1634:
1623:. Retrieved
1619:the original
1605:
1586:
1549:
1543:
1516:
1510:
1501:
1492:
1459:
1455:
1449:
1424:
1420:
1414:
1379:
1375:
1365:
1351:
1342:
1333:
1322:. Retrieved
1296:10665/325771
1286:
1277:
1265:. Retrieved
1223:
1203:. Retrieved
1195:
1186:
1174:. Retrieved
1170:
1161:
1149:. Retrieved
1145:
1136:
1124:. Retrieved
1117:
1108:
1083:
1073:Research on
1072:
1065:
1063:
1048:
1035:
1030:
1020:
960:
948:
920:
911:
908:Side effects
883:
870:
859:
848:Medical uses
827:
776:
755:
751:
750:
531:NIAID ChemDB
520:ChEMBL254316
310:Elimination
214:Legal status
208:Legal status
114:License data
29:
3398:Pyrimidones
3388:Oxadiazoles
3213:Famciclovir
3167:Sitagliptin
3162:Simvastatin
3147:Rizatriptan
3142:Raltegravir
3132:Montelukast
3107:Finasteride
3082:Alendronate
2926:recommended
2901:from market
2851:Lersivirine
2826:Capravirine
2765:Miltefosine
2750:Griffithsin
2745:Fosdevirine
2291:Censavudine
1921:(primarily
1770:NCT00554398
1645:BMC Biology
1003:methylation
999:benzylamine
977:to form an
935:chromosomes
894:cholesterol
838:combination
766:, to treat
752:Raltegravir
678: g·mol
618:100.124.631
500:CHEBI:82960
367:518048-05-0
332:Identifiers
133:Raltegravir
100:MedlinePlus
73:Other names
64:Trade names
34:Raltegravir
3372:Categories
3320:Geriatrics
3313:Veterinary
3261:Facilities
3228:Mometasone
3223:Loratadine
3218:Infliximab
3177:Vorinostat
3172:Vericiguat
3127:Lovastatin
3087:Aprepitant
3066:Viralytics
2856:Lodenosine
2836:Droxinavir
2821:Brecanavir
2816:Atevirdine
2780:Seliciclib
2775:Scytovirin
2689:Elipovimab
2634:TRIM5alpha
2311:Stampidine
2216:inhibitors
2200:TMC-310911
2099:BMS-955176
1997:Leronlimab
1989:Vicriviroc
1736:2024-07-29
1625:2009-11-15
1324:2009-11-15
1267:8 December
1100:References
983:pyrimidone
842:lamivudine
793:including
764:medication
683:3D model (
671:Molar mass
551:PDB ligand
452:22VKV8053U
423:ChemSpider
358:CAS Number
341:IUPAC name
300:Metabolism
3203:Ezetimibe
3152:Rofecoxib
3117:Indinavir
3097:Ezetimibe
3092:Ertapenem
2911:Phase III
2899:Withdrawn
2876:Telinavir
2871:Palinavir
2866:Mozenavir
2846:Emivirine
2841:Lasinavir
2811:Aplaviroc
2740:Foscarnet
2720:Ceragenin
2281:Amdoxovir
2094:Bevirimat
2071:BI 224436
1651:(1): 71.
1484:195685470
979:amidoxime
945:Chemistry
927:integrase
886:efavirenz
807:pregnancy
787:headaches
756:Isentress
323:Excretion
312:half-life
284:60% (FDA)
170:Routes of
144:Pregnancy
92:Monograph
86:Drugs.com
68:Isentress
18:Isentress
3350:Medicine
3243:Tibolone
3122:Losartan
3075:Products
2861:Loviride
1871:Archived
1814:18650512
1713:18763751
1677:22035460
1578:75449475
1476:19496631
1441:17426263
1398:17721395
1285:(2019).
1171:DailyMed
1045:Research
880:Efficacy
768:HIV/AIDS
758:, is an
432:16445111
403:DrugBank
392:54671008
184:ATC code
177:By mouth
159: B3
146:category
128:DailyMed
3362:Viruses
3336:Portals
2760:KP-1461
2306:Racivir
2076:MK-2048
1668:3203851
1406:6130143
1343:Reuters
1205:12 July
1176:11 July
1151:11 July
1126:1 April
1017:History
676:444.423
635:Formula
412:DB06817
378:PubChem
317:9 hours
226::
200:)
194: (
192:J05AJ01
130::
106:a608004
3306:Manual
2894:WHO-EM
2710:BIT225
2705:Abzyme
2636:(gene)
2323:NtRTIs
2218:(RTIs)
1812:
1711:
1675:
1665:
1598:
1576:
1566:
1531:
1482:
1474:
1439:
1404:
1396:
1230:
1031:et al.
1005:using
931:enzyme
921:As an
801:, and
785:, and
779:nausea
709:SMILES
540:471309
511:ChEMBL
480:D07133
472:D06676
253:â„ž-only
251:
238:
228:â„ž-only
126:
3299:Index
2698:Other
2681:BNAbs
2241:NRTIs
2020:gp120
1574:S2CID
1480:S2CID
1456:Drugs
1402:S2CID
1199:(EMA)
1146:(emc)
1027:Merck
995:amide
991:ester
929:, an
862:HAART
840:with
729:InChI
685:JSmol
558:RLT (
491:ChEBI
2923:DHHS
1979:CCR5
1967:gp41
1810:PMID
1709:PMID
1673:PMID
1564:ISBN
1529:ISBN
1472:PMID
1437:PMID
1421:JAMA
1394:PMID
1269:2017
1228:ISBN
1207:2021
1178:2021
1153:2021
1128:2024
971:base
836:, a
561:PDBe
463:KEGG
443:UNII
274:data
82:AHFS
2004:CD4
1923:J05
1919:HIV
1800:doi
1796:359
1701:doi
1663:PMC
1653:doi
1554:doi
1521:doi
1464:doi
1429:doi
1425:297
1384:doi
1291:hdl
1057:or
969:as
890:RNA
809:or
584:EPA
382:CID
294:83%
240:POM
197:WHO
76:RAL
3374::
2907::
2011:,
1995:,
1991:,
1913::
1849:.
1830:.
1808:.
1794:.
1790:.
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1470:.
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1392:.
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1374:.
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1242:^
1215:^
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1169:.
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832:.
825:.
797:,
781:,
649:21
643:20
564:,
259:EU
247:US
234:UK
223:CA
155:AU
123:US
3338::
2963:e
2956:t
2949:v
2921:°
2509:°
2503:°
2497:°
2486:°
2470:°
2454:°
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2347:(
2325::
2321:/
2243::
2239:/
2191:°
2185:°
2122:)
2118:(
2027:)
2023:(
2015:)
2007:(
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1982:(
1974:)
1970:(
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1209:.
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655:N
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