257:), where he cloned and sequenced cDNAs coding for cytoskeletal proteins, actin and alpha keratins. He elucidated the first structures of cytoskeletal keratin families, and predicted the long helical domains of these proteins. By computerized analysis of amino acid sequences he predicted that the central rod domain of intermediate filament proteins is composed of four helical segments separated by three short linker sequences. Later crystallographic studies have confirmed this as a general model for intermediate filament protein structure.
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skin and epidermal appendages, they found a widespread distribution of ENaC in keratinocytes in the epidermal layers. Yet, in the eccrine sweat glands, ENaC was localized on the apical cell membrane exposed to the duct of these sweat glands. Based on additional observations, they concluded that the ENaC located on the eccrine gland sweat ducts is responsible for the uptake of Na ions from sweat secretions. This recycling of Na reduces the concentration of salt in perspiration and prevents the loss of salt at hot climates via
292:, but the NADPH binding site has a different consensus sequence that could be responsible for NAD vs. NADP coenzyme specificity. The importance of the motifs he identified was confirmed by re-engineering of coenzyme specificities of different enzymes. Elucidation of the crystal structure of adrenodoxin reductase further verified Israel's identification of the coenzyme binding sites. Analysis of the phylogeny of this enzyme in eukaryotes showed that the NADP binding site sequence is strictly conserved.
356:
discovery that in all cells with motile cilia ENaC is located on cilia. These studies establish that ENaC is an important regulator of fluid level in the luminal side of cells with motile cilia in the female reproductive and respiratory tract. More recently, they showed that these sodium channels are also located in the seminiferous tubules in the testis and in the tail and head region of sperm.
273:) via an electron-transfer chain that includes two additional proteins. These proteins are located on the inner mitochondrial membrane. Israel reconstituted this system using proteins he purified, characterized the process of electron transfer between the proteins, and built a kinetic model that simulated precisely the dynamic behavior of this complex system.
326:, Sackler Medical School and E. Wolfson Medical Center), identified that a hereditary disease named pseudohypoaldosteronism (PHA) type I encompasses two independent syndromes. Following this discovery the two brothers continued their collaboration to understand the molecular basis of the severe form of PHA.
232:
for graduate studies and received his M.Sc. degree in 1976 in an inter-disciplinary
Endocrinology-Reproductive physiology program, under the joint supervision of Prof. Harry J. Karavolas (Dept. of Physiological Chemistry) and Prof. Robert W. Goy (Dept. of Psychology). His Ph.D. thesis research on the
359:
Systemic pseudohypoaldosteronism patients with mutated ENaC subunits may lose significant amount salt in sweat especially at hot climates. To identify the sites of salt loss, Hanukoglu brothers examined the localization of ENaC in the human skin. In a comprehensive study examining all the layers of
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As the steroidogenic tissues have very high levels of antioxidants, Israel suspected that the P450 systems may leak electrons producing oxygen radicals. He examined this issue and showed that indeed, electrons that leak during the action mitochondrial P450 systems generate reactive oxygen species.
427:
Besides a scientific career, Hanukoglu has maintained an active academic and civic leadership role. In 2003, Hanukoglu founded Israel's first B.Sc. degree program in
Molecular Biology at the Ariel University Center. He served as the Chairman of the Molecular Biology Department from 2003 to 2008.
355:
To define the sites of localization of ENaC in tissues and within cells, Hanukoglu's laboratory generated polyclonal antibodies against extracellular ENaC subunits. These antibodies for the first time permitted visualization of intracellular localization of ENaC at high resolution and led to the
344:
Following these studies, the
Hanukoglu brothers directed their attention to understand the structure and function of ENaC assembled from normal and mutated subunits. Their analyses showed that the phenotypic variations in the severity of pseudohypoaldosteronism are associated with the types of
472:
Hanukoglu's website, the Israel
Science and Technology Homepage, had included a page captioned, "Long-Form Birth Certificate of Obama is a Forged Document." The analyses presented asserted that "without a doubt that the Long-Form Birth Certificate of Mr. Obama is a fabricated, fake and forged
431:
Hanukoglu has been an editorial board member/Associate editor in five journals, including
Biochemistry and Molecular Biology Education, BMC Biotechnology, Cells, Frontiers in Renal and Epithelial Physiology, and Gene. In 2018, he received Publons Peer Review Award for placing in the top 1% of
1746:
Chang SS, Grunder S, Hanukoglu A, Rösler A, Mathew PM, Hanukoglu I, Schild L, Lu Y, Shimkets RA, Nelson-Williams C, Rossier BC, Lifton RP (March 1996). "Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1".
287:
By sequence and structural analyses of adrenodoxin reductase, Israel identified its binding sites for the electron donor and acceptor coenzymes, NADPH and FAD. By sequence analyses of the large oxidoreductase type of enzyme families, he noted that the FAD-binding site is a classical
280:, he first determined the molar stoichiometry of the mitochondrial P450 system proteins using specific antibodies that he generated. He then set out to clone the cDNAs and the genes that code for these enzymes. His lab was the first to clone the cDNAs and the gene coding for
1831:
Edelheit O, Hanukoglu I, Gizewska M, Kandemir N, Tenenbaum-Rakover Y, Yurdakök M, Zajaczek S, Hanukoglu A (May 2005). "Novel mutations in epithelial sodium channel (ENaC) subunit genes and phenotypic expression of multisystem pseudohypoaldosteronism".
1924:
Hanukoglu A, Edelheit O, Shriki Y, Gizewska M, Dascal N, Hanukoglu I (September 2008). "Renin-aldosterone response, urinary Na/K ratio and growth in pseudohypoaldosteronism patients with mutations in epithelial sodium channel (ENaC) subunit genes".
1968:
Edelheit O, Hanukoglu I, Shriki Y, Tfilin M, Dascal N, Gillis D, Hanukoglu A (March 2010). "Truncated beta epithelial sodium channel (ENaC) subunits responsible for multi-system pseudohypoaldosteronism support partial activity of ENaC".
439:, a self-described "non-partisan organization of academics united by a shared concern for the security and the Jewish character of the State of Israel." From 1996 to 1999 he served as the science adviser to the prime minister of Israel
233:"Mechanism of electron transport to cytochrome P-450 in adrenal cortex mitochondrial steroid monooxygenase systems" was carried out under the supervision of Prof. Colin R. Jefcoate. He received his Ph.D. diploma in August 1980.
2012:
Edelheit O, Hanukoglu I, Dascal N, Hanukoglu A (April 2011). "Identification of the roles of conserved charged residues in the extracellular domain of an epithelial sodium channel (ENaC) subunit by alanine mutagenesis".
345:
genetic mutations. Their work on the structure of ENaC subunits led to the identification of charged residues and regions responsible for transport of the protein to membrane and for regulation of extracellular Na ions.
341:) that encode for protein subunits of the Epithelial sodium (Na) channel (ENaC). These studies also helped establish that ENaC is the principal channel involved in blood volume and blood pressure regulation in humans.
269:
in all steroidogenic tissues, including the adrenal cortex, and the reproductive organs. The first step of steroidogenesis is dependent on the transfer of electrons from NADPH to a P450 type enzyme (
303:) in regulating steroid hormone synthesis in the adrenal cortex, regulation of adrenal steroidogenic capacity in disease states, and the cloning and elucidation of the structure of ACTH receptor.
2155:
Enuka Y, Hanukoglu I, Edelheit O, Vaknine H, Hanukoglu A (March 2012). "Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways".
329:
By their collaborative work that also included additional labs, the
Hanukoglu brothers discovered that the severe forms of pseudohypoaldosteronism type I result from mutations in three genes (
954:"Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum. Implications for membrane organization and gene regulation"
196:
in
Istanbul until the end of junior high school. In ninth grade, he switched to Atatürk Erkek Lisesi in Taksim, Istanbul, graduating in 1969. In his senior year, he was selected for an
1792:"Novel mutations responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial sodium channel alpha-, beta-, and gamma-subunit genes"
2198:
Sharma S, Hanukoglu A, Hanukoglu I (2018). "Localization of epithelial sodium channel (ENaC) and CFTR in the germinal epithelium of the testis, Sertoli cells, and spermatozoa".
2462:
1188:
Ziegler GA, Vonrhein C, Hanukoglu I, Schulz GE (Jun 1999). "The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis".
2354:
2467:
2058:"Conserved charged residues at the surface and interface of epithelial sodium channel subunits--roles in cell surface expression and the sodium self-inhibition response"
419:
In addition to the personal prizes above, the research presentations from the laboratory of Prof. Hanukoglu received four awards at national and international meetings.
2457:
1538:
Hanukoglu A, Fried D, Nakash I, Hanukoglu I (Nov 1995). "Selective increases in adrenal steroidogenic capacity during acute respiratory disease in infants".
467:
2492:
2452:
541:
Hanukoglu I, Tanese N, Fuchs E (Feb 1983). "Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions".
2522:
2512:
2507:
2497:
382:
277:
1668:"Type I pseudohypoaldosteronism includes two clinically and genetically distinct entities with either renal or multiple target organ defects"
2472:
578:"The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins"
229:
1354:"Antioxidant protective mechanisms against reactive oxygen species (ROS) generated by mitochondrial P450 systems in steroidogenic cells"
1223:
Hanukoglu I (2017). "Conservation of the Enzyme-Coenzyme
Interfaces in FAD and NADP Binding Adrenodoxin Reductase-A Ubiquitous Enzyme".
310:
in 1991 which served as the cornerstone for a continuing series of international symposia for scientists who specialize in this field.
2482:
2477:
2437:
2432:
995:"Isolation of a cDNA for adrenodoxin reductase (ferredoxin-NADP+ reductase). Implications for mitochondrial cytochrome P-450 systems"
444:
2517:
2502:
2371:
2351:
1080:"Human adrenodoxin reductase: two mRNAs encoded by a single gene on chromosome 17cen----q25 are expressed in steroidogenic tissues"
1276:"Electron leakage from the mitochondrial NADPH-adrenodoxin reductase-adrenodoxin-P450scc (cholesterol side chain cleavage) system"
861:"Induction and mitochondrial localization of cytochrome P450scc system enzymes in normal and transformed ovarian granulosa cells"
1877:"Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases"
1137:
Scrutton NS, Berry A, Perham RN (Jan 1990). "Redesign of the coenzyme specificity of a dehydrogenase by protein engineering".
436:
265:
During his Ph.D. thesis research, Israel isolated the mitochondrial enzymes that catalyze the first step in the synthesis of
225:
1620:
Hanukoglu, I. (Dec 1992). "Current research on steroid metabolism: transition from biochemistry to molecular-cell biology".
1705:
Strautnieks SS, Thompson RJ, Hanukoglu A, Dillon MJ, Hanukoglu I, Kuhnle U, Seckl J, Gardiner RM, Chung E (February 1996).
2447:
2442:
773:"Adrenal mitochondrial cytochrome P-450scc. Cholesterol and adrenodoxin interactions at equilibrium and during turnover"
1440:"Mechanism of corticotropin and cAMP induction of mitochondrial cytochrome P450 system enzymes in adrenal cortex cells"
296:
His studies also showed that in bovine ovary, levels of antioxidants are coordinately regulated with steroidogenesis.
201:
625:"The cDNA sequence of a Type II cytoskeletal keratin reveals constant and variable structural domains among keratins"
1707:"Localisation of pseudohypoaldosteronism genes to chromosome 16p12.2-13.11 and 12p13.1-pter by homozygosity mapping"
458:. For 12 years (1996–2008), he served as a founding member of the Ariel Center for Policy Research executive board.
1401:"Antioxidant capacity is correlated with steroidogenic status of the corpus luteum during the bovine estrous cycle"
1315:"Electron leakage from the adrenal cortex mitochondrial P450scc and P450c11 systems: NADPH and steroid dependence"
348:
In an extensive review of studies on ASIC and ENaC, Prof. Hanukoglu has summarized the major similarities between
388:
National Cancer
Institute, National Research Service Award for Postdoctoral Fellowship in Biochemistry (1982).
2107:"ASIC and ENaC type sodium channels: Conformational states and the structures of the ion selectivity filters"
1481:"Mitochondrial-genome-encoded RNAs: differential regulation by corticotropin in bovine adrenocortical cells"
193:
2487:
373:
197:
97:
Mechanism of electron transport to cytochrome P-450 in adrenal cortex mitochondrial monooxygenase systems
2246:"Expression of epithelial sodium channel (ENaC) and CFTR in the human epidermis and epidermal appendages"
407:
2016 Sentinel of
Science Award for peer review in Biochemistry, Genetics and Molecular Biology by Publons
281:
250:
205:
413:
2018 Publons Peer Review Award. Ranked in the top 1% of reviewers in "Molecular Biology and Genetics".
2413:
Crystal Structure of NADP binding enzyme that details the structural properties of NADP binding motif
1492:
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1146:
1091:
319:
814:"Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis"
455:
323:
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In this field, Israel organized the first International Symposium in Molecular Steroidogenesis in
2273:
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2180:
2134:
2087:
2038:
1994:
1950:
1857:
1772:
1645:
1563:
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1256:
1170:
1039:"cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases"
841:
750:
652:
605:
440:
2305:"Gene Wiki Reviews-Raising the quality and accessibility of information about the human genome"
1078:
Solish SB, Picado-Leonard J, Morel Y, Kuhn RW, Mohandas TK, Hanukoglu I, Miller WL (Oct 1988).
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His other work in this field includes elucidation of the mechanism of action of corticotropin (
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2265:
2215:
2172:
2126:
2079:
2030:
1986:
1942:
1906:
1849:
1813:
1764:
1728:
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1583:"cDNA cloning and sequence analysis of the bovine adrenocorticotropic hormone (ACTH) receptor"
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1334:
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1016:
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833:
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597:
558:
164:
672:"Structural basis for heteromeric assembly and perinuclear organization of keratin filaments"
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Lubell Prize for the outstanding young scientist at the Weizmann Institute of Science (1991).
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2118:
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1978:
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550:
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140:
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Tsueng G, Good BM, Ping P, Golemis E, Hanukoglu I, van Wijnen AJ, Su AI (5 November 2016).
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249:
Hanukoglu's career in molecular biology started at the Department of Biochemistry of the
2379:
1496:
1236:
1150:
1095:
412:
406:
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Prof. Hanukoglu's scientific work concentrated in three different areas outlined below.
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1901:
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1011:
970:
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860:
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with double majors in biology and psychology and a minor in political science from the
172:
156:
1456:
1416:
1114:
1079:
929:
789:
772:
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2244:
Hanukoglu I, Boggula VR, Vaknine H, Sharma S, Kleyman T, Hanukoglu A (January 2017).
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829:
640:
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451:
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120:
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1954:
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Saxena A, Hanukoglu I, Saxena D, Thompson RJ, Gardiner RM, Hanukoglu A (July 2002).
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284:- the first enzyme in the electron transfer chain of the mitochondrial P450 system.
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2227:
2091:
1998:
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910:"Mitochondrial cytochrome P-450scc. Mechanism of electron transport by adrenodoxin"
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124:
2042:
845:
909:
2026:
1982:
1938:
1399:
Rapoport R, Sklan D, Wolfenson D, Shaham-Albalancy A, Hanukoglu I (March 1998).
394:
Delta Research Career Development Award at Weizmann Institute of Science (1987).
2320:
1892:
1485:
Proceedings of the National Academy of Sciences of the United States of America
1084:
Proceedings of the National Academy of Sciences of the United States of America
2261:
2211:
2168:
1369:
1244:
398:
The first Hans Lindner Prize in Endocrinology, Israel Endocrine Society (1988)
1505:
2402:
2291:
1104:
397:
391:
Technion V.P.R. Fund-Henri Gutwirth Award for Excellence in Research (1984).
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209:
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2269:
2219:
2176:
2130:
2083:
2056:
Edelheit O, Ben-Shahar R, Dascal N, Hanukoglu A, Hanukoglu I (April 2014).
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1990:
1946:
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1808:
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1377:
1330:
1291:
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876:
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705:
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979:
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648:
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reviewers in "Molecular Biology and Genetics" with a global rank of 22nd.
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In his clinical work as an endocrinologist, Israel's older brother, Prof.
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2057:
1760:
270:
179:(1996–1999). He is founder of Israel Science and Technology Directory.
737:
720:
687:
529:
512:
2418:
Google Scholar profile of citations of Prof. Hanukoglu's publications
1158:
771:
Hanukoglu I, Spitsberg V, Bumpus JA, Dus KM, Jefcoate CR (May 1981).
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334:
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176:
152:
91:
490:
55:
Keratin structure, steroidogenic enzymes, epithelial sodium channels
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1667:
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1439:
1400:
1353:
1314:
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1038:
994:
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577:
450:
In 2003 he was appointed as the scientific advisor to the mayor of
276:
In his first academic position at the Department of Biology at the
2407:
349:
300:
200:(AFS) International Scholarship. As an AFS student, he attended
859:
Hanukoglu I, Suh BS, Himmelhoch S, Amsterdam A (October 1990).
1587:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
1274:
Hanukoglu I, Rapoport R, Weiner L, Sklan D (September 1993).
670:
Lee CH, Kim MS, Chung BM, Leahy DJ, Coulombe PA (Jul 2012).
2372:"Long-Form Birth Certificate of Obama is a Forged Document"
993:
Hanukoglu I, Gutfinger T, Haniu M, Shively JE (Dec 1987).
376:
International Scholarship (from Turkey to the USA) (1969).
1971:
The Journal of Steroid Biochemistry and Molecular Biology
1927:
The Journal of Steroid Biochemistry and Molecular Biology
818:
The Journal of Steroid Biochemistry and Molecular Biology
443:. Hanukoglu was placed as an honorary candidate on the
435:
In 1995, Hanukoglu was elected as the Chairman of the
1438:
Hanukoglu I, Feuchtwanger R, Hanukoglu A (Nov 1990).
1796:
The Journal of Clinical Endocrinology and Metabolism
1672:
The Journal of Clinical Endocrinology and Metabolism
2239:
2237:
513:
Israel Science and Technology Directory: About page
379:
Ford Foundation Fellowship in Endocrinology (1975).
220:Israel Hanukoglu received his undergraduate degree
116:
106:
90:
82:
74:
59:
51:
43:
35:
25:
18:
1313:Rapoport R, Sklan D, Hanukoglu I (10 March 1995).
1661:
1659:
1581:Raikhinstein M, Zohar M, Hanukoglu I (Feb 1994).
1032:
1030:
171:and former science and technology adviser to the
2015:American Journal of Physiology. Renal Physiology
766:
764:
721:"Proteopedia: Coiled-coil structure of keratins"
212:, and received his high-school diploma in 1970.
2150:
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524:
522:
520:
8:
468:Barack Obama citizenship conspiracy theories
15:
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1900:
1807:
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1504:
1455:
1113:
1103:
1054:
1010:
969:
928:
884:
788:
736:
695:
676:Nature Structural & Molecular Biology
511:Israel Science and Technology Directory.
2468:Israeli people of Turkish-Jewish descent
1479:Raikhinstein M, Hanukoglu I (Nov 1993).
385:Fellowship Award in Biochemistry (1981).
2408:Home page of Professor Israel Hanukoglu
1875:Hanukoglu I, Hanukoglu A (April 2016).
1319:Archives of Biochemistry and Biophysics
1280:Archives of Biochemistry and Biophysics
481:
383:Damon Runyon Cancer Research Foundation
278:Technion-Israel Institute of Technology
2463:University of Wisconsin–Madison alumni
2458:Hebrew University of Jerusalem alumni
1037:Hanukoglu I, Gutfinger T (Mar 1989).
952:Hanukoglu I, Hanukoglu Z (May 1986).
908:Hanukoglu I, Jefcoate CR (Apr 1980).
7:
409:(1st place among Israeli Scientists)
188:Elementary and high school education
1444:The Journal of Biological Chemistry
917:The Journal of Biological Chemistry
777:The Journal of Biological Chemistry
462:Obama birth certificate controversy
2493:Joseph A. Craig High School alumni
2453:Academic staff of Ariel University
2361:Israel Ministry of Foreign Affairs
1056:10.1111/j.1432-1033.1989.tb14671.x
1012:10.1111/j.1432-1033.1987.tb13632.x
971:10.1111/j.1432-1033.1986.tb09633.x
14:
623:Hanukoglu I, Fuchs E (Jul 1983).
576:Hanukoglu I, Fuchs E (Nov 1982).
1846:10.1111/j.1365-2265.2005.02255.x
1043:European Journal of Biochemistry
999:European Journal of Biochemistry
958:European Journal of Biochemistry
719:Hanukoglu I, Ezra L (Jan 2014).
456:Jewish Nobel Laureates Boulevard
314:Epithelial sodium channel (ENaC)
2523:20th-century Israeli scientists
2513:20th-century Turkish scientists
2508:21st-century Israeli scientists
2498:21st-century Turkish scientists
2352:Candidates for the 16th Knesset
2250:Histochemistry and Cell Biology
2157:Histochemistry and Cell Biology
230:University of Wisconsin–Madison
78:Biochemistry, molecular biology
2200:Journal of Molecular Histology
1225:Journal of Molecular Evolution
437:Professors for a Strong Israel
226:Hebrew University of Jerusalem
47:Hebrew University of Jerusalem
1:
1666:Hanukoglu A (November 1991).
1457:10.1016/S0021-9258(17)30545-8
1417:10.1016/S0304-4165(97)00136-0
930:10.1016/S0021-9258(19)85851-9
790:10.1016/S0021-9258(19)69436-6
445:Herut – The National Movement
423:Academic and civic activities
1634:10.1016/0960-0760(92)90304-2
1599:10.1016/0167-4889(94)90157-0
1190:Journal of Molecular Biology
830:10.1016/0960-0760(92)90307-5
641:10.1016/0092-8674(83)90034-X
594:10.1016/0092-8674(82)90424-X
555:10.1016/0022-2836(83)90117-1
543:Journal of Molecular Biology
493:. Israel National News (INN)
117:Other academic advisors
2473:Turkish emigrants to Israel
2105:Hanukoglu I (August 2016).
2027:10.1152/ajprenal.00648.2010
1983:10.1016/j.jsbmb.2010.01.002
1939:10.1016/j.jsbmb.2008.06.013
865:The Journal of Cell Biology
202:Joseph A. Craig High School
2539:
2321:10.1016/j.gene.2016.04.053
1893:10.1016/j.gene.2015.12.061
1622:J Steroid Biochem Mol Biol
465:
192:Israel Hanukoglu attended
2483:21st-century Turkish Jews
2478:20th-century Turkish Jews
2438:21st-century Israeli Jews
2433:20th-century Israeli Jews
2262:10.1007/s00418-016-1535-3
2212:10.1007/s10735-018-9759-2
2169:10.1007/s00418-011-0904-1
1370:10.1080/03602530600570040
1245:10.1007/s00239-017-9821-9
261:Steroid hormone synthesis
130:
67:
2518:20th-century biochemists
2503:21st-century biochemists
1711:Human Molecular Genetics
1506:10.1073/pnas.90.22.10509
812:Hanukoglu I (Dec 1992).
489:Ofra Lax (11 May 2003).
352:and ENaC type channels.
237:Contributions to science
1358:Drug Metabolism Reviews
1105:10.1073/pnas.85.19.7104
194:tr:Şişli Terakki Lisesi
1834:Clinical Endocrinology
1809:10.1210/jcem.87.7.8674
1405:Biochim. Biophys. Acta
1331:10.1006/abbi.1995.1182
1292:10.1006/abbi.1993.1452
1202:10.1006/jmbi.1999.2807
877:10.1083/jcb.111.4.1373
374:American Field Service
245:Structures of keratins
228:. He then went to the
198:American Field Service
144:
1684:10.1210/jcem-73-5-936
1552:10.1530/eje.0.1330552
725:Biochem Mol Biol Educ
454:for establishing the
282:adrenodoxin reductase
251:University of Chicago
2448:Molecular biologists
1352:Hanukoglu I (2006).
2443:Israeli biochemists
2382:on 22 December 2016
1724:10.1093/hmg/5.2.293
1497:1993PNAS...9010509R
1237:2017JMolE..85..205H
1151:1990Natur.343...38S
1096:1988PNAS...85.7104S
324:Tel Aviv University
155:scientist. He is a
2357:2015-06-27 at the
2290:Israel Hanukoglu.
2123:10.1111/febs.13840
2075:10.1111/febs.12765
1761:10.1038/ng0396-248
528:Israel Hanukoglu.
441:Benjamin Netanyahu
2376:www.science.co.il
1090:(19): 7104–7108.
738:10.1002/bmb.20746
688:10.1038/nsmb.2330
415:Global rank: 22nd
216:College education
165:molecular biology
134:
133:
69:Scientific career
2530:
2391:
2390:
2388:
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2378:. Archived from
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2241:
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2102:
2096:
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2062:The FEBS Journal
2053:
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2009:
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1965:
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1578:
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1540:Eur J Endocrinol
1535:
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1518:
1508:
1491:(22): 10509–13.
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1459:
1435:
1429:
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1396:
1390:
1389:
1349:
1343:
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1185:
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932:
914:
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792:
768:
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530:Curriculum Vitae
526:
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267:steroid hormones
253:(1980–1983 with
169:Ariel University
145:İsrael Hanukoğlu
137:Israel Hanukoglu
123:, David Nelson,
108:Doctoral advisor
102:
86:Ariel University
30:Istanbul, Turkey
20:Israel Hanukoglu
16:
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2403:BRIEF BIOGRAPHY
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2359:Wayback Machine
2350:
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2192:
2154:
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2068:(8): 2097–111.
2055:
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2050:
2011:
2010:
2006:
1967:
1966:
1962:
1933:(3–5): 268–74.
1923:
1922:
1918:
1874:
1873:
1869:
1830:
1829:
1825:
1789:
1788:
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1749:Nature Genetics
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1364:(1–2): 171–96.
1351:
1350:
1346:
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1307:
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1268:
1222:
1221:
1217:
1187:
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1145:(6253): 38–43.
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320:Aaron Hanukoglu
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44:Alma mater
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2004:
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2016:
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1977:(1–2): 84–8.
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1972:
1964:
1961:
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1952:
1948:
1944:
1940:
1936:
1932:
1928:
1920:
1917:
1912:
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1887:(2): 95–132.
1886:
1882:
1878:
1871:
1868:
1863:
1859:
1855:
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1843:
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1801:
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1411:(1): 133–40.
1410:
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1375:
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1367:
1363:
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1332:
1328:
1324:
1320:
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1293:
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1286:(2): 489–98.
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1254:
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1246:
1242:
1238:
1234:
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1196:(4): 981–90.
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1049:(2): 479–84.
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1004:
1000:
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989:
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823:
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800:
796:
791:
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783:(9): 4321–8.
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739:
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726:
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698:
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682:(7): 707–15.
681:
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638:
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531:
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461:
459:
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453:
452:Rishon LeZion
448:
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290:Rossmann fold
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66:
63:Lindner Prize
62:
58:
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42:
38:
34:
28:
24:
17:
2384:. Retrieved
2380:the original
2375:
2366:
2347:
2315:(2): 235–8.
2312:
2308:
2298:
2286:
2253:
2249:
2203:
2199:
2193:
2160:
2156:
2114:
2110:
2100:
2065:
2061:
2051:
2018:
2014:
2007:
1974:
1970:
1963:
1930:
1926:
1919:
1884:
1880:
1870:
1837:
1833:
1826:
1799:
1795:
1785:
1752:
1748:
1741:
1717:(2): 293–9.
1714:
1710:
1700:
1675:
1671:
1628:(8): 745–9.
1625:
1621:
1615:
1590:
1586:
1576:
1546:(5): 552–6.
1543:
1539:
1533:
1488:
1484:
1474:
1447:
1443:
1433:
1408:
1404:
1394:
1361:
1357:
1347:
1325:(2): 412–6.
1322:
1318:
1308:
1283:
1279:
1269:
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1224:
1218:
1193:
1189:
1183:
1142:
1138:
1132:
1087:
1083:
1073:
1046:
1042:
1002:
998:
988:
964:(1): 27–31.
961:
957:
947:
920:
916:
903:
868:
864:
854:
821:
817:
807:
780:
776:
731:(1): 93–94.
728:
724:
714:
679:
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665:
632:
628:
618:
585:
581:
571:
549:(4): 673–8.
546:
542:
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507:
497:10 September
495:. Retrieved
484:
471:
449:
434:
430:
426:
418:
362:perspiration
358:
354:
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343:
328:
317:
305:
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255:Elaine Fuchs
248:
240:
221:
219:
191:
161:biochemistry
136:
135:
125:W.W. Cleland
96:
83:Institutions
68:
473:document."
36:Nationality
2427:Categories
2386:2016-12-16
477:References
206:Janesville
491:"Besheva"
308:Jerusalem
222:cum laude
210:Wisconsin
183:Education
2355:Archived
2339:27150585
2270:28130590
2220:29453757
2185:15178940
2177:22207244
2139:24402104
2131:27580245
2084:24571549
2035:21209000
1991:20064610
1955:24688546
1947:18634878
1911:26772908
1854:15853823
1818:12107247
1642:22217821
1568:44439040
1386:10766948
1378:16684656
1253:29177972
1210:10369776
838:22217824
755:30720797
747:24265184
706:22705788
657:21490380
610:35796315
2330:5944608
2278:8504408
2228:3761720
2092:5807500
1999:9564777
1902:4756657
1862:2749562
1777:8185511
1769:8589714
1733:8824886
1692:1939532
1650:5789778
1607:8305507
1560:7581984
1525:7504267
1493:Bibcode
1466:2173715
1425:9545562
1339:7893157
1300:8396893
1261:7120148
1233:Bibcode
1175:1580419
1167:2296288
1147:Bibcode
1124:2845396
1092:Bibcode
1065:2924777
1021:3691502
980:3011431
939:6766943
895:2170421
886:2116250
799:7217084
697:3864793
649:6191871
602:6186381
563:6842590
271:P450scc
153:Israeli
149:Turkish
147:) is a
141:Turkish
39:Israeli
2337:
2327:
2276:
2268:
2226:
2218:
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2175:
2137:
2129:
2090:
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2043:869654
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1997:
1989:
1953:
1945:
1909:
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1251:
1208:
1173:
1165:
1139:Nature
1122:
1115:282132
1112:
1063:
1019:
978:
937:
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883:
846:112729
844:
836:
797:
753:
745:
704:
694:
655:
647:
608:
600:
561:
447:list.
368:Awards
339:SCNN1B
337:, and
335:SCNN1B
331:SCNN1A
177:Israel
151:-born
101:(1980)
99:
92:Thesis
75:Fields
60:Awards
2274:S2CID
2224:S2CID
2181:S2CID
2135:S2CID
2088:S2CID
2039:S2CID
1995:S2CID
1951:S2CID
1858:S2CID
1773:S2CID
1646:S2CID
1564:S2CID
1516:47806
1382:S2CID
1257:S2CID
1171:S2CID
913:(PDF)
842:S2CID
751:S2CID
653:S2CID
606:S2CID
2335:PMID
2309:Gene
2266:PMID
2216:PMID
2173:PMID
2127:PMID
2080:PMID
2031:PMID
1987:PMID
1943:PMID
1907:PMID
1881:Gene
1850:PMID
1814:PMID
1765:PMID
1729:PMID
1688:PMID
1638:PMID
1603:PMID
1591:1220
1556:PMID
1521:PMID
1462:PMID
1421:PMID
1409:1380
1374:PMID
1335:PMID
1296:PMID
1249:PMID
1206:PMID
1163:PMID
1120:PMID
1061:PMID
1017:PMID
976:PMID
935:PMID
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