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focused on two such transporters, P-glycoprotein and MRP1. This initial work has led to new insights into a mechanism by which some cancer cells mount resistance to chemotherapy. Discovered in the 1970s, P-glycoprotein recognizes an array of structurally related compounds and pumps them out of the cell. It plays a Jekyll-and-Hyde role in human health: When the cell in question is cancerous and the compounds are therapies targeting some aspect of the cell’s internal machinery, P-glycoprotein’s action reduces the effectiveness of chemotherapy.
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Chen’s interests have recently shifted to ABC transporters involved in the immune system and disease. These are a diverse group of membrane proteins utilizing the chemical energy of ATP hydrolysis to transport substrates against their electrochemical gradients. Her initial work with ABC transporters
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Chen's current research focuses on ABC transporters and their roles in, specifically, cystic fibrosis. Among the thousands of ABC transporters, one member, the cystic fibrosis transmembrane conductance regulator (CFTR), has evolved to function as an ATP-gated ion channel. Mutation of the
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Chen is known for doing meaningful work in the fields of membrane biology and biophysics. She has published notable works in the fields of crystallography, intracellular transport, and, most recently, ATP-Binding
Cassette Transporters and their roles in immune systems and disease. Her work on
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She has also been using crystallography to visualize how the maltose transporter protein converts the chemical energy of ATP hydrolysis into mechanical work through a series of conformational changes. This work applies specifically to bacterial cells, but has implications for humans.
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Crystal structure of the severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein dimerization domain reveals evolutionary linkage between corona-and arteriviridae. IM Yu, ML Oldham, J Zhang, J Chen. Journal of
Biological Chemistry 281 (25),
243:
where she won a number of teaching awards and published her research in high impact journals. In 2007, Chen was promoted to associate professor and subsequently, professor in 2011. In 2003 she was named a
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ATP hydrolysis is required to reset the ATP-binding cassette dimer into the resting-state conformation. G Lu, JM Westbrooks, AL Davidson, J Chen. Proceedings of the
National Academy of Sciences 102 (50),
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Association of the pr peptides with dengue virus at acidic pH blocks membrane fusion. IM Yu, HA Holdaway, PR Chipman, RJ Kuhn, MG Rossmann, J Chen. Journal of virology 83 (23), 12101-12107
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A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter. ML Oldham, RK Hite, AM Steffen, E Damko, Z Li, T Walz, J Chen. Nature 529 (7587), 537-540
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Chen, Jue; Skehel, John J.; Wiley, Don C. (September 1998). "A Polar
Octapeptide Fused to the N-Terminal Fusion Peptide Solubilizes the Influenza Virus HA2Subunit Ectodomain†".
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Structure of the immature dengue virus at low pH primes proteolytic maturation. IM Yu, W Zhang, HA Holdaway, L Li, VA Kostyuchenko, PR Chipman, ... Science 319 (5871), 1834-1837
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Structure, function, and evolution of bacterial ATP-binding cassette systems. AL Davidson, E Dassa, C Orelle, J Chen. Microbiology and molecular biology reviews 72 (2), 317-364
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The flavivirus precursor membrane-envelope protein complex: structure and maturation. L Li, SM Lok, IM Yu, Y Zhang, RJ Kuhn, J Chen, MG Rossmann. Science 319 (5871), 1830-1834
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Structural identification of a hotspot on CFTR for potentiation. F Liu, Z Zhang, A Levit, J Levring, KK Touhara, BK Shoichet, J Chen. Science 364 (6446), 1184-1188
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effector protein mimicking a eukaryotic ubiquitin ligase. J Diao, Y Zhang, JM Huibregtse, D Zhou, J Chen. Nature structural & molecular biology 15 (1), 65-70
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A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle. J Chen, G Lu, J Lin, AL Davidson, FA Quiocho. Molecular cell 12 (3), 651-661
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Molecular structure of the ATP-bound, phosphorylated human CFTR. Z Zhang, F Liu, J Chen. Proceedings of the
National Academy of Sciences 115 (50), 12757-12762
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Carbon catabolite repression of the maltose transporter revealed by X-ray crystallography. S Chen, ML Oldham, AL Davidson, J Chen. Nature 499 (7458), 364-368
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Alternating access in maltose transporter mediated by rigid-body rotations. D Khare, ML Oldham, C Orelle, AL Davidson, J Chen. Molecular cell 33 (4), 528-536
617:"N- and C-terminal residues combine in the fusion-pH influenza hemagglutinin HA2 subunit to form an N cap that terminates the triple-stranded coiled coil"
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Crystal structure of a catalytic intermediate of the maltose transporter. ML Oldham, D Khare, FA Quiocho, AL Davidson, J Chen. Nature 450 (7169), 515-521
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Snapshots of the maltose transporter during ATP hydrolysis. ML Oldham, J Chen. Proceedings of the
National Academy of Sciences 108 (37), 15152-15156
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Structure of a TRPM2 channel in complex with Ca explains unique gating regulation. Z Zhang, B Toth, A Szollosi, J Chen, L Csanady. elife 7, e36409
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Structure and function of a HECT domain ubiquitin‐binding site. HC Kim, AM Steffen, ML Oldham, J Chen, JM Huibregtse. EMBO reports 12 (4), 334-341
970:
560:"Structure of the Hemagglutinin Precursor Cleavage Site, a Determinant of Influenza Pathogenicity and the Origin of the Labile Conformation"
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Structural insights into ABC transporter mechanism. ML Oldham, AL Davidson, J Chen. Current opinion in structural biology 18 (6), 726-733
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Crystal structure of the maltose transporter in a pretranslocation intermediate state. ML Oldham, J Chen. Science 332 (6034), 1202-1205
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Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation. Y Kim, J Chen. Science 359 (6378), 915-919
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Structural basis of substrate recognition by the multidrug resistance protein MRP1. ZL Johnson, J Chen. Cell 168 (6), 1075-1085. e9
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Molecular mechanism of the
Escherichia coli maltose transporter. J Chen. Current opinion in structural biology 23 (4), 492-498
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Crystal structures of a polypeptide processing and secretion transporter. DY Lin, S Huang, J Chen. Nature 523 (7561), 425-430
154:. She is the William E. Ford professor of biochemistry and head of the Laboratory of Membrane Biology and Biophysics at the
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Atomic structure of the cystic fibrosis transmembrane conductance regulator. Z Zhang, J Chen. Cell 167 (6), 1586-1597. e9
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Molecular structure of the human CFTR ion channel. F Liu, Z Zhang, L Csanády, DC Gadsby, J Chen. Cell 169 (1), 85-95. e8
346:
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ATP binding enables substrate release from multidrug resistance protein 1. ZL Johnson, J Chen. Cell 172 (1), 81-89. e10
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Conformational changes of CFTR upon phosphorylation and ATP binding. Z Zhang, F Liu, J Chen. Cell 170 (3), 483-491. e8
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gene causes cystic fibrosis (CF), a lethal disease with a prevalence of 1 in 2500 in
Caucasian populations.
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ATP-binding cassette transporters in bacteria. AL Davidson, J Chen. Annual review of biochemistry 73 (1), 241-268
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Chen, Jue; Lee, Kon Ho; Steinhauer, David A; Stevens, David J; Skehel, John J; Wiley, Don C (October 1998).
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Molecular structure of human KATP in complex with ATP and ADP. KPK Lee, J Chen, R MacKinnon. Elife 6, e32481
256:, where she is now the William E. Ford Professor and Head of Laboratory of Membrane Biology and Biophysics.
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Chen, Jue; Lu, Gang; Lin, Jeffrey; Davidson, Amy L; Quiocho, Florante A (September 2003).
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investigator. Her research focuses on elucidating the structure and function of
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933:"Chemistry Seminar | Alumna, Honorary Degree Recipient Jue Chen, April 29"
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Crystal structure of the multidrug transporter P-glycoprotein from
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ATP-binding cassette (ABC) transporters and P-glycoprotein and MRP1
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MS Jin, ML Oldham, Q Zhang, J Chen. Nature 490 (7421), 566-569
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In 2019, she was elected to the
National Academy of Sciences.
504:"Alumni News | Chen Elected to National Academy of Sciences"
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Anatrace
Membrane Protein Award, Biophysical Society (2018)
209:, where she discovered unique structural features of the
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Chen, J.; Skehel, J. J.; Wiley, D. C. (1999-08-03).
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937:Ohio University | College of Arts & Sciences
508:Ohio University | College of Arts & Sciences
318:ATP-binding cassette (ABC) transporters and CFTR
252:Investigator in 2008 In 2014, she moved to The
959:. National Academy of Sciences. April 30, 2019.
621:Proceedings of the National Academy of Sciences
534:"The Rockefeller University » Lab Members"
239:In 2002, Chen became an assistant professor at
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300:Visualizing maltose through crystallography
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197:in 1993, and went on to pursue a PhD in
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164:ATP-binding cassette (ABC) transporters
1066:Chinese emigrants to the United States
1036:21st-century American women scientists
86:Structural studies of ABC transporters
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272:includes investigating their role in
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186:before moving to the United States.
1011:Howard Hughes Medical Investigators
189:She earned a bachelor's degree in
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235:ATP binding cassette transporters
233:, where she started studying the
1031:21st-century American biologists
229:from 1999 to 2001 in the lab of
205:in 1998 under the mentorship of
16:Chinese-born American biochemist
250:Howard Hughes Medical Institute
160:Howard Hughes Medical Institute
1001:Rockefeller University faculty
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577:10.1016/s0092-8674(00)81771-7
379:Crystal structure of SopA, a
146:) is a Chinese-born American
736:10.1016/j.molcel.2003.08.004
347:National Academy of Sciences
31:when mentioning individuals.
296:; and bacterial nutrition.
213:responsible for infection
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1021:American women biochemists
227:Baylor College of Medicine
18:
1026:Harvard University alumni
1016:Purdue University faculty
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1071:Tongji University alumni
170:Early life and education
27:. This article uses
19:The native form of this
634:10.1073/pnas.96.16.8967
477:Yu, Rong (2019-05-10).
415:Caenorhabditis elegans.
1061:Chinese women chemists
1006:Ohio University alumni
479:"长沙市一中校友陈珏当选美国国家科学院院士"
254:Rockefeller University
156:Rockefeller University
116:Rockefeller University
1081:Biologists from Hunan
1076:Educators from Hunan
1051:People from Changsha
282:antigen presentation
148:structural biologist
1056:Chinese biochemists
1046:Chemists from Hunan
957:"2019 NAS Election"
931:lori (2022-04-07).
860:"2019 NAS Election"
682:(39): 13643–13649.
538:lab.rockefeller.edu
231:Florante A. Quiocho
975:scholar.google.com
203:Harvard University
95:Roderick MacKinnon
74:Harvard University
29:Western name order
864:www.nasonline.org
786:www.nasonline.org
759:"Jue Chen, Ph.D."
688:10.1021/bi981098l
627:(16): 8967–8972.
331:Awards and honors
286:adaptive immunity
241:Purdue University
221:Chen remained in
180:Tongji University
174:Chen was born in
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103:Scientific career
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278:chemotherapy
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223:Don C. Wiley
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207:Don C. Wiley
199:biochemistry
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109:Institutions
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24:
483:Hunan Daily
373:17134-17139
369:17969-17974
337:Pew Scholar
246:Pew Scholar
54:Citizenship
995:Categories
980:2023-10-10
971:"Jue Chen"
942:2023-10-10
917:2023-10-10
908:"Jue Chen"
893:2023-10-10
884:"Jue Chen"
869:2020-05-03
845:2020-07-12
836:"Jue Chen"
811:"Jue Chen"
791:2020-07-12
782:"Jue Chen"
767:2020-07-12
514:2020-05-02
489:2019-05-17
464:References
381:Salmonella
274:resistance
152:biochemist
696:0006-2960
643:0027-8424
586:0092-8674
191:chemistry
820:25 April
745:14527411
661:10430879
602:11232474
543:25 April
358:Source:
263:Research
184:Shanghai
176:Changsha
136:Jue Chen
97:( 2017-)
38:Jue Chen
25:Chen Jue
704:9753451
594:9814710
280:drugs;
140:Chinese
762:bit.ly
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349:(2019)
339:(2003)
248:and a
217:Career
158:and a
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91:Spouse
652:17716
598:S2CID
201:from
193:from
48:China
822:2019
741:PMID
700:PMID
692:ISSN
657:PMID
639:ISSN
590:PMID
582:ISSN
564:Cell
545:2019
325:CFTR
288:and
150:and
44:Born
731:doi
684:doi
647:PMC
629:doi
572:doi
345:US
284:in
276:to
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