323:. He has also collaborated with Assistant Professor of Chemistry Emily Derbyshire at Duke University investigating how a lipid-protein compound in the cells of the malaria parasite help make the parasite able to withstand high temperatures brought on by fever. In April 2019, Niles was made Director of the
307:
to embed the technologies to control when genes are turned on or turned off. Once Niles has identified the specific genes a compound might target, he can control the expression of that gene to make parasites more susceptible to the compound, then map the sensitivity relationships to understand the
265:. Heme is a biomolecule that interacts with several malarial drugs. To study this, he created a heme-sensing protein, whose fluorescence diminishes upon binding to heme. By expressing the heme-sening protein in the target
845:
194:
445:
Burney, Samar; Caulfield, Jennifer L.; Niles, Jacquin C.; Wishnok, John S.; Tannenbaum, Steven R. (1999). "The chemistry of DNA damage from nitric oxide and peroxynitrite".
835:
269:
parasite, Niles made it possible to monitor the levels of heme through changes in fluorescence. Niles used this to show that malarial parasites contain high levels of
840:
218:
600:
Han, Jongyoon; Suresh, Subra; Niles, Jacquin C.; Dao, Ming; Goldfless, Stephen J.; Diez-Silva, Monica; Pivkin, Igor V.; Bow, Hansen (2011-02-28).
731:
850:
324:
230:
186:
158:
88:
41:
295:
data of these parasites, then builds a sequence of technologies to enter parasites and manipulate when genes are expressed. Niles performs
209:
and nitric oxide. He looked to understand the increased cancer risks with inflammatory diseases. Niles was a postdoctoral scholar in the
320:
806:
343:
210:
92:
303:, which, alongside compound efficacy, provides information about exactly which targets the compound is interacting with. Niles uses
397:
202:
181:, and stayed there until he finished high school. In high school he became interested in biology and chemistry. Niles studied
246:
237:
Director's New
Innovator Award. His research considers engineered parasites for the diagnosis, prevention and treatment of
855:
242:
234:
292:
682:
280:
could be used to disrupt parasite genes, which provides information about how parasites invade and replicate inside
299:
to understand which parasites should be taken for further development. Niles embeds target information within the
525:
489:
266:
258:
782:
657:
576:
300:
296:
206:
198:
122:
53:
316:
304:
45:
706:
162:
106:
Chemical characterization of the peroxynitrite-induced guanine and 8-oxyguanine reaction products
62:
58:
370:
639:
621:
462:
49:
629:
613:
454:
214:
166:
117:
538:
502:
189:
and graduated in 1994. During his undergraduate degree he completed a research project on
132:
344:"Chemistry in Action: Jacquin Niles | MIT OpenCourseWare | Free Online Course Materials"
634:
601:
281:
254:
458:
241:. He develops tools to regulate gene expression, as well as probes to interrogate the
829:
783:"Generous funding to malaria-parasite researcher promises new therapeutic strategies"
658:"Generous funding to malaria-parasite researcher promises new therapeutic strategies"
201:. He earned an MD and PhD in Molecular Toxicology. During his doctorate he studied
602:"A microfabricated deformability-based flow cytometer with application to malaria"
552:
517:
481:
421:
312:
190:
761:
398:"Jacquin Niles named director of the Center for Environmental Health Sciences"
625:
250:
182:
643:
518:"Engineered Regulated RNA Localization and Transport in Biological Systems"
466:
807:"Duke researchers discover how malaria parasites withstand a fever's heat"
288:
178:
30:
105:
617:
238:
157:
is an
American Professor of Biological Engineering and Director of the
447:
Mutation
Research/Fundamental and Molecular Mechanisms of Mutagenesis
277:
270:
161:
Center for
Environmental Health Sciences. In an effort to design new
99:
273:
262:
146:
846:
Massachusetts
Institute of Technology School of Science alumni
763:
MIT Technology Day 2017: Professor
Jacquin Niles '94, PhD '01
261:
controls heme levels and designed a technique to monitor
249:. To do this, Niles developed an automated deformability
276:
than anticipated. Additionally, Niles demonstrated that
732:"Re-engineering the malaria parasite for drug delivery"
253:
that can measure the dynamic, mechanical responses of
311:
He is part of a multi-institution investigation into
195:
Harvard–MIT Program of Health
Sciences and Technology
169:
and investigates how it interacts with human hosts.
142:
128:
116:
98:
84:
69:
37:
25:
18:
308:relationships between compounds and target genes.
482:"Minority Predoctoral Fellowship Program - NIGMS"
217:. His postdoctoral work was supported by the
8:
327:Center for Environmental Health Sciences.
287:The Niles lab collects publicly available
15:
633:
707:"Easier way to manipulate malaria genes"
219:National Human Genome Research Institute
836:Caribbean diaspora in the United States
335:
683:"Taking Aim at a Key Malaria Molecule"
534:
523:
498:
487:
229:Niles was appointed to the faculty at
197:, and worked under the supervision of
760:MIT Alumni Association (2017-06-28),
755:
753:
751:
325:Massachusetts Institute of Technology
231:Massachusetts Institute of Technology
187:Massachusetts Institute of Technology
159:Massachusetts Institute of Technology
89:Massachusetts Institute of Technology
42:Massachusetts Institute of Technology
7:
687:Science and Technology Research News
392:
390:
365:
363:
321:University of California, Riverside
193:. He was a graduate student in the
257:. Niles is also interested in how
211:University of California, Berkeley
93:University of California, Berkeley
14:
841:MIT School of Engineering faculty
1:
851:Harvard Medical School alumni
681:Rasmussen, Ray (2017-03-01).
459:10.1016/S0027-5107(99)00006-8
371:"Engineering foe into friend"
235:National Institutes of Health
730:in-pharmatechnologist.com.
233:in 2008. He was awarded an
73:Antimalarial drug discovery
872:
577:"Faculty Scholars Program"
247:host–pathogen interactions
245:in malarial parasites and
736:in-pharmatechnologist.com
138:
77:
315:parasites, working with
173:Early life and education
533:Cite journal requires
497:Cite journal requires
267:plasmodium falciparum
259:plasmodium falciparum
856:Anguillan scientists
301:phenotypic screening
297:phenotypic screening
207:chronic inflammation
199:Steven R. Tannenbaum
165:, Niles studies the
123:Steven R. Tannenbaum
305:CRISPR gene editing
225:Research and career
618:10.1039/C0LC00472C
553:"Niles Laboratory"
422:"Niles Laboratory"
177:Niles was born in
163:antimalarial drugs
59:Harvard University
152:
151:
129:Doctoral students
79:Scientific career
863:
821:
820:
818:
817:
803:
797:
796:
794:
793:
779:
773:
772:
771:
770:
757:
746:
745:
743:
742:
727:
721:
720:
718:
717:
703:
697:
696:
694:
693:
678:
672:
671:
669:
668:
654:
648:
647:
637:
612:(6): 1065–1073.
597:
591:
590:
588:
587:
573:
567:
566:
564:
563:
549:
543:
542:
536:
531:
529:
521:
516:Niles, Jacquin.
513:
507:
506:
500:
495:
493:
485:
480:Niles, Jacquin.
477:
471:
470:
442:
436:
435:
433:
432:
418:
412:
411:
409:
408:
394:
385:
384:
382:
381:
367:
358:
357:
355:
354:
340:
215:Michael Marletta
167:malaria parasite
155:Jacquin C. Niles
118:Doctoral advisor
112:
16:
871:
870:
866:
865:
864:
862:
861:
860:
826:
825:
824:
815:
813:
805:
804:
800:
791:
789:
781:
780:
776:
768:
766:
759:
758:
749:
740:
738:
729:
728:
724:
715:
713:
705:
704:
700:
691:
689:
680:
679:
675:
666:
664:
656:
655:
651:
599:
598:
594:
585:
583:
575:
574:
570:
561:
559:
551:
550:
546:
532:
522:
515:
514:
510:
496:
486:
479:
478:
474:
444:
443:
439:
430:
428:
420:
419:
415:
406:
404:
396:
395:
388:
379:
377:
369:
368:
361:
352:
350:
348:ocw.aprende.org
342:
341:
337:
333:
293:transcriptomics
282:red blood cells
255:red blood cells
243:heme metabolism
227:
175:
133:Christina Birch
110:
91:
57:
33:
21:
12:
11:
5:
869:
867:
859:
858:
853:
848:
843:
838:
828:
827:
823:
822:
798:
774:
747:
722:
698:
673:
649:
592:
568:
544:
535:|journal=
508:
499:|journal=
472:
453:(1–2): 37–49.
437:
413:
386:
359:
334:
332:
329:
317:Karine Le Roch
226:
223:
174:
171:
150:
149:
144:
140:
139:
136:
135:
130:
126:
125:
120:
114:
113:
102:
96:
95:
86:
82:
81:
75:
74:
71:
70:Known for
67:
66:
39:
35:
34:
29:
27:
23:
22:
19:
13:
10:
9:
6:
4:
3:
2:
868:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
833:
831:
812:
808:
802:
799:
788:
784:
778:
775:
765:
764:
756:
754:
752:
748:
737:
733:
726:
723:
712:
708:
702:
699:
688:
684:
677:
674:
663:
659:
653:
650:
645:
641:
636:
631:
627:
623:
619:
615:
611:
607:
606:Lab on a Chip
603:
596:
593:
582:
578:
572:
569:
558:
554:
548:
545:
540:
527:
519:
512:
509:
504:
491:
483:
476:
473:
468:
464:
460:
456:
452:
448:
441:
438:
427:
423:
417:
414:
403:
399:
393:
391:
387:
376:
372:
366:
364:
360:
349:
345:
339:
336:
330:
328:
326:
322:
318:
314:
309:
306:
302:
298:
294:
290:
285:
283:
279:
275:
272:
268:
264:
260:
256:
252:
248:
244:
240:
236:
232:
224:
222:
220:
216:
212:
208:
204:
200:
196:
192:
188:
184:
180:
172:
170:
168:
164:
160:
156:
148:
145:
141:
137:
134:
131:
127:
124:
121:
119:
115:
108:
107:
103:
101:
97:
94:
90:
87:
83:
80:
76:
72:
68:
64:
60:
55:
51:
47:
43:
40:
36:
32:
28:
24:
20:Jacquin Niles
17:
814:. Retrieved
810:
801:
790:. Retrieved
786:
777:
767:, retrieved
762:
739:. Retrieved
735:
725:
714:. Retrieved
711:ScienceDaily
710:
701:
690:. Retrieved
686:
676:
665:. Retrieved
661:
652:
609:
605:
595:
584:. Retrieved
580:
571:
560:. Retrieved
556:
547:
526:cite journal
511:
490:cite journal
475:
450:
446:
440:
429:. Retrieved
425:
416:
405:. Retrieved
401:
378:. Retrieved
374:
351:. Retrieved
347:
338:
313:apicomplexan
310:
286:
228:
176:
154:
153:
104:
85:Institutions
78:
787:EurekAlert!
662:EurekAlert!
557:web.mit.edu
426:web.mit.edu
191:nitrogenase
830:Categories
816:2020-11-18
811:Duke Today
792:2019-04-16
769:2019-04-16
741:2019-04-16
716:2019-04-16
692:2019-04-16
667:2019-04-16
586:2019-04-16
562:2019-04-16
431:2019-04-16
407:2019-04-16
380:2019-04-16
353:2019-04-16
331:References
205:caused by
203:DNA damage
626:1473-0189
251:cytometer
183:chemistry
147:Niles Lab
38:Education
644:21293801
581:HHMI.org
467:10064848
402:MIT News
375:MIT News
289:genomics
179:Anguilla
31:Anguilla
635:3366288
239:malaria
185:at the
143:Website
642:
632:
624:
465:
278:CRISPR
271:labile
111:(2000)
109:
100:Thesis
213:with
640:PMID
622:ISSN
539:help
503:help
463:PMID
291:and
274:heme
263:heme
26:Born
630:PMC
614:doi
455:doi
451:424
319:at
284:.
54:PhD
832::
809:.
785:.
750:^
734:.
709:.
685:.
660:.
638:.
628:.
620:.
610:11
608:.
604:.
579:.
555:.
530::
528:}}
524:{{
494::
492:}}
488:{{
461:.
449:.
424:.
400:.
389:^
373:.
362:^
346:.
221:.
63:MD
52:,
50:MS
48:,
46:BS
819:.
795:.
744:.
719:.
695:.
670:.
646:.
616::
589:.
565:.
541:)
537:(
520:.
505:)
501:(
484:.
469:.
457::
434:.
410:.
383:.
356:.
65:)
61:(
56:)
44:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.