339:
316:
213:
238:
604:
597:
590:
345:
244:
42:
1765:
68:
1436:
in the NOTCH signaling pathway which helps to determine cellular fate and is active during many developmental stages. The extracellular component of the JAG1 protein physically interacts with its respective Notch receptor. This interaction kicks off a cascade of
1678:, all of the known mutations lead to loss of the function of one copy, and, there is no correlation between mutation type or location and disease severity. Though individuals with ALGS have several body systems affected, there is a subset of individuals with
3201:
Li L, Krantz ID, Deng Y, Genin A, Banta AB, Collins CC, Qi M, Trask BJ, Kuo WL, Cochran J, Costa T, Pierpont ME, Rand EB, Piccoli DA, Hood L, Spinner NB (1997). "Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1".
1701:
expression changes have been implicated in many types of cancer. Specifically, up regulation of JAG1 has been correlated with both poor overall breast cancer survival rates and an enhancement of tumor proliferation in adrenocortical carcinoma patients.
5839:
5844:
1540:
expression patterns correlate with organ systems affected in ALGS, although it is important to note that not all tissues where JAG1 is expressed are affected in ALGS. More recently JAG1 expression has been found to be altered in
1341:. The Notch signaling pathway is a highly conserved pathway that functions to establish and regulate cell fate decisions in many organ systems. Once the JAG1-NOTCH (receptor-ligand) interactions take place, a cascade of
3128:
Lindsell CE, Boulter J, diSibio G, Gossler A, Weinmaster G (1997). "Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development".
3450:
Pilia G, Uda M, Macis D, Frau F, Crisponi L, Balli F, Barbera C, Colombo C, Frediani T, Gatti R, Iorio R, Marazzi MG, Marcellini M, Musumeci S, Nebbia G, Vajro P, Ruffa G, Zancan L, Cao A, DeVirgilis S (2000).
2736:
Warthen DM, Moore EC, Kamath BM, Morrissette JJ, Sanchez-Lara PA, Sanchez P, Piccoli DA, Krantz ID, Spinner NB (2006). "Jagged1 (JAG1) mutations in
Alagille syndrome: increasing the mutation detection rate".
2870:
Crosnier C, Driancourt C, Raynaud N, Dhorne-Pollet S, Pollet N, Bernard O, Hadchouel M, Meunier-Rotival M (1999). "Mutations in JAGGED1 gene are predominantly sporadic in
Alagille syndrome".
1690:
that do not show the other clinical signs of the syndrome. Given the variable expressivity of the disease, there may be other genetic or environmental modifiers present beyond the original
4537:
3494:
Wong MK, Prudovsky I, Vary C, Booth C, Liaw L, Mousa S, Small D, Maciag T (2000). "A non-transmembrane form of Jagged-1 regulates the formation of matrix-dependent chord-like structures".
1552:
Mouse models where the Jag1 gene is turned off in certain tissues (conditional knockout mouse models) have been used to study the role of Jag1 in many tissue specific areas. While
3676:
5713:
352:
251:
4527:
3313:"PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor"
2905:
Bauer RC, Laney AO, Smith R, Gerfen J, Morrissette JJ, Woyciechowski S, Garbarini J, Loomes KM, Krantz ID, Urban Z, Gelb BD, Goldmuntz E, Spinner NB (2010).
4507:
3644:
1621:
1580:, and cranial neural crest all exhibit features classic to those in individuals with ALGS, highlighting the role of this tissue type in disease origins
1067:
5369:
3693:
3669:
1048:
174:
5813:
5100:
1666:, and whole gene deletions accounting for 80%, 7%, and 12% respectively. Since all mutation types lead to a patient phenotype, it is thought that
2091:
Shimizu K, Chiba S, Saito T, Kumano K, Hirai H (2000). "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors".
5088:
4866:
5834:
5706:
5152:
5147:
5093:
4873:
3654:
1922:
5849:
4606:
4532:
3662:
1904:
1995:
Oda T, Elkahloun AG, Pike BL, Okajima K, Krantz ID, Genin A, Piccoli DA, Meltzer PS, Spinner NB, Collins FS, Chandrasekharappa SC (1997).
5635:
5630:
5625:
5620:
4547:
2128:"Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation"
2402:
McCright B, Lozier J, Gridley T (2002). "A mouse model of
Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency".
2210:"Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2"
338:
145:, Jag1, ABE2, Gsfabe2, Htu, Ozz, Ser-1, AGS, AHD, AWS, CD339, HJ1, JAGL1, jagged 1, AGS1, DCHE, jagged canonical Notch ligand 1, CMT2HH
3469:
3452:
1274:
1267:
5600:
3241:"Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12"
3278:"The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1"
315:
5699:
4836:
3364:
Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S (1999).
2480:"Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome"
5404:
4898:
4584:
1891:
1870:
5043:
4579:
237:
212:
3621:
3541:
3524:
3311:
Hock B, BΓΆhme B, Karn T, Yamamoto T, Kaibuchi K, Holtrich U, Holland S, Pawson T, RΓΌbsamen-Waigmann H, Strebhardt K (1998).
2314:"High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival"
1887:
3409:"Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors"
3048:"Gene alterations identified by expression profiling in tumor-associated endothelial cells from invasive ovarian carcinoma"
65:
5540:
5012:
5007:
4952:
4686:
4135:
1625:
3168:"An antisense oligonucleotide to the notch ligand jagged enhances fibroblast growth factor-induced angiogenesis in vitro"
2439:"The expression of Jagged1 in the developing mammalian heart correlates with cardiovascular disease in Alagille syndrome"
1866:
5234:
4957:
154:
4552:
2529:"Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome"
1772:
The 2015 version of this article was updated by an external expert under a dual publication model. The corresponding
3046:
Lu C, Bonome T, Li Y, Kamat AA, Han LY, Schmandt R, Coleman RL, Gershenson DM, Jaffe RB, Birrer MJ, Sood AK (2007).
351:
250:
5264:
3689:
1746:
1370:
1345:
cleavages is triggered resulting in activation of the transcription for downstream target genes. Located on human
4130:
2637:"Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients"
1741:
1569:
1461:
344:
243:
2478:
Hofmann JJ, Briot A, Enciso J, Zovein AC, Ren S, Zhang ZW, Radtke F, Simons M, Wang Y, Iruela-Arispe ML (2012).
5314:
4209:
3630:
1546:
1112:
162:
2169:"Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods"
3616:
1642:. Over half of individuals with mutations in the gene did not inherit it from either parent, and thus have a
5734:
5726:
5278:
1616:. The most clinically significant concerns stem from liver, heart, vascular or renal problems. Mutations in
1433:
1338:
1093:
2167:
Shimizu K, Chiba S, Kumano K, Hosoya N, Takahashi T, Kanda Y, Hamada Y, Yazaki Y, Hirai H (November 1999).
4621:
4616:
4611:
4601:
3908:
3836:
2208:
Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (September 2000).
2437:
Loomes KM, Underkoffler LA, Morabito J, Gottlieb S, Piccoli DA, Spinner NB, Baldwin HS, Oakey RJ (1999).
5766:
3965:
3883:
1773:
1736:
1457:
1382:
1334:
226:
2578:"Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development"
1674:
is the likely disease mechanism of action. Although individuals can have a range of mutation types in
5202:
4915:
3324:
2689:"Spectrum and frequency of jagged1 (JAG1) mutations in Alagille syndrome patients and their families"
2589:
141:
5722:
5229:
5048:
3273:
1731:
1683:
2831:"Defective intracellular transport and processing of JAG1 missense mutations in Alagille syndrome"
4636:
4370:
3626:
3554:
3482:
3227:
3154:
3116:
2762:
2635:
Humphreys R, Zheng W, Prince LS, Qu X, Brown C, Loomes K, Huppert SS, Baldwin S, Goudy S (2012).
2073:
2024:
1974:
1726:
1721:
1687:
1667:
1589:
1354:
186:
1250:
1229:
1203:
1182:
3636:
3597:
3568:"The Notch Ligand Jagged-1 Represents a Novel Growth Factor of Human Hematopoietic Stem Cells"
3546:
3511:
3474:
3438:
3395:
3352:
3299:
3272:
Li L, Milner LA, Deng Y, Iwata M, Banta A, Graf L, Marcovina S, Friedman C, Trask BJ, Hood L,
3260:
3219:
3189:
3146:
3108:
3069:
3028:
2977:
2936:
2887:
2852:
2811:
2754:
2718:
2666:
2617:
2558:
2509:
2460:
2419:
2384:
2335:
2291:
2239:
2190:
2149:
2108:
2065:
2016:
1966:
1826:
1808:
1716:
1565:
1390:
1358:
134:
58:
5691:
5409:
5142:
5063:
4626:
3819:
3745:
3587:
3579:
3536:
3503:
3464:
3428:
3420:
3385:
3377:
3342:
3332:
3289:
3252:
3211:
3179:
3138:
3100:
3059:
3018:
3008:
2967:
2926:
2918:
2879:
2842:
2801:
2793:
2746:
2708:
2700:
2656:
2648:
2607:
2597:
2548:
2540:
2499:
2491:
2450:
2411:
2374:
2366:
2325:
2281:
2273:
2229:
2221:
2180:
2139:
2100:
2055:
2008:
1956:
1834:
1816:
1800:
1521:
1513:
603:
596:
589:
431:
362:
306:
261:
2312:
Reedijk M, Odorcic S, Chang L, Zhang H, Miller N, McCready DR, Lockwood G, Egan SE (2005).
5469:
4005:
4000:
3923:
1711:
1613:
1406:
406:
182:
3328:
2593:
5254:
4676:
4187:
3990:
3592:
3567:
3433:
3408:
3390:
3365:
3023:
2996:
2931:
2906:
2806:
2781:
2713:
2688:
2661:
2636:
2612:
2577:
2553:
2528:
2504:
2479:
2379:
2354:
2286:
2262:"JAGGED1 expression in human embryos: correlation with the Alagille syndrome phenotype"
2261:
1821:
1791:
1786:
1410:
3381:
3294:
3277:
2954:
Dickson BC, Mulligan AM, Zhang H, Lockwood G, O'Malley FP, Egan SE, Reedijk M (2007).
2883:
982:
977:
972:
967:
962:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
721:
716:
711:
706:
701:
696:
691:
686:
670:
665:
660:
655:
650:
645:
41:
5828:
5224:
4681:
3772:
3648:
3347:
3312:
2234:
2225:
2209:
1961:
1944:
1542:
1442:
1402:
1398:
1394:
1346:
632:
3558:
3486:
3120:
2907:"Jagged1 (JAG1) mutations in patients with tetralogy of Fallot or pulmonic stenosis"
2766:
2077:
1978:
166:
5746:
5580:
4888:
4878:
4409:
4375:
3231:
3158:
2028:
1557:
1446:
424:
203:
3064:
3047:
2370:
2330:
2313:
2060:
2043:
3566:
Karanu FN, Murdoch B, Gallacher L, Wu DM, Koremoto M, Sakano S, Bhatia M (2000).
3525:"Jagged1 (JAG1) mutation detection in an Australian Alagille syndrome population"
3523:
Heritage ML, MacMillan JC, Colliton RP, Genin A, Spinner NB, Anderson GJ (2000).
2797:
1628:
in 1997. Patients who are clinically consistent with the disorder usually have a
190:
5590:
5239:
5017:
4992:
4691:
4313:
4239:
3713:
1927:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1909:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1785:
Christopher M Grochowski, Kathleen M Loomes, Nancy B Spinner (6 November 2015).
1651:
1577:
1529:
1517:
1438:
1414:
1342:
3424:
2687:
Krantz ID, Colliton RP, Genin A, Rand EB, Li L, Piccoli DA, Spinner NB (1998).
2527:
Hofmann JJ, Zovein AC, Koh H, Radtke F, Weinmaster G, Iruela-Arispe ML (2010).
1804:
507:
17:
5520:
5244:
4925:
4666:
4542:
4175:
4170:
4165:
4020:
3804:
2972:
2955:
1655:
1573:
1553:
1505:
1429:
323:
220:
170:
3184:
3167:
2185:
2168:
1812:
823:
cardiac neural crest cell development involved in outflow tract morphogenesis
5359:
5354:
5349:
5339:
5334:
5329:
5324:
3337:
3013:
2602:
2455:
2438:
1561:
1468:
plays in development and its effects on different organ systems. In humans,
1012:
567:
445:
390:
377:
289:
276:
178:
5840:
Knowledge (XXG) articles with corresponding academic peer reviewed articles
3601:
3583:
3550:
3515:
3507:
3478:
3442:
3399:
3256:
3142:
3112:
3073:
3032:
2981:
2940:
2891:
2856:
2847:
2830:
2815:
2758:
2670:
2621:
2562:
2513:
2464:
2423:
2415:
2388:
2339:
2295:
2243:
2194:
2153:
2144:
2127:
2112:
2104:
2069:
1997:"Mutations in the human Jagged1 gene are responsible for Alagille syndrome"
1830:
3356:
3303:
3264:
3223:
3193:
3166:
Zimrin AB, Pepper MS, McMahon GA, Nguyen F, Montesano R, Maciag T (1997).
3150:
2722:
2355:"Upregulated JAG1 enhances cell proliferation in adrenocortical carcinoma"
2020:
1970:
1838:
1314:
1309:
5665:
5565:
5379:
5364:
4567:
4562:
4470:
4160:
3470:
10.1002/(SICI)1098-1004(199911)14:5<394::AID-HUMU5>3.0.CO;2-1
3407:
Bash J, Zong WX, Banga S, Rivera A, Ballard DW, Ron Y, GΓ©linas C (1999).
3104:
3091:
Piccoli DA, Spinner NB (2002). "Alagille syndrome and the Jagged1 gene".
2652:
2277:
2126:
Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (July 2001).
1764:
1663:
1659:
1629:
1601:
1525:
1485:
1481:
1473:
1298:
1157:
1138:
2956:"High-level JAG1 mRNA and protein predict poor outcome in breast cancer"
5808:
5803:
5798:
5615:
5610:
5605:
5505:
5319:
5309:
5136:
5115:
5110:
5078:
4883:
4803:
4798:
4793:
4788:
4783:
4701:
4394:
4234:
4229:
4224:
4219:
4214:
3685:
3215:
2922:
2750:
2544:
2495:
2012:
1609:
1533:
1353:
gene is expressed in multiple organ systems in the body and causes the
1124:
1079:
5845:
Knowledge (XXG) articles with corresponding articles published in Gene
1556:
deletions of Jag1 have been shown to be embryonic lethal in mice, and
111:
107:
103:
99:
95:
91:
87:
5555:
5515:
5500:
5484:
5479:
5459:
5454:
5389:
5197:
5167:
5131:
5122:
4935:
4903:
4767:
4762:
4732:
4711:
4671:
4631:
4497:
4475:
4434:
4358:
4353:
4348:
4343:
4338:
4333:
4202:
4197:
4192:
4140:
4125:
3995:
3985:
3948:
3943:
3861:
3856:
1638:
1501:
1497:
1493:
1282:
1034:
3240:
2576:
High FA, Lu MM, Pear WS, Loomes KM, Kaestner KH, Epstein JA (2008).
1996:
3542:
10.1002/1098-1004(200011)16:5<408::AID-HUMU5>3.0.CO;2-9
2704:
1620:
were first discovered to be responsible for ALGS by researchers at
1592:
multi-system disorder affecting several body systems including the
978:
positive regulation of cardiac epithelial to mesenchymal transition
5680:
5655:
5575:
5570:
5560:
5550:
5535:
5530:
5525:
5510:
5464:
5449:
5414:
5399:
5394:
5384:
5304:
5299:
5294:
5273:
5269:
5259:
5172:
5073:
5068:
5027:
4977:
4972:
4967:
4962:
4947:
4940:
4920:
4908:
4851:
4846:
4841:
4831:
4826:
4819:
4757:
4747:
4742:
4737:
4727:
4706:
4696:
4661:
4656:
4651:
4646:
4641:
4596:
4591:
4557:
4522:
4517:
4512:
4502:
4490:
4485:
4465:
4460:
4455:
4450:
4404:
4296:
4291:
4110:
4094:
4087:
4082:
4077:
4072:
4067:
4062:
4037:
4015:
4010:
3903:
3829:
3824:
3814:
3453:"Jagged-1 mutation analysis in Italian Alagille syndrome patients"
1597:
1593:
1477:
1418:
1361:(ALGS) resulting from loss of function mutations within the gene.
1787:"Jagged1 (JAG1): Structure, expression, and disease associations"
1449:
of the cell leading to the activation of different target genes.
997:
993:
5782:
5756:
5751:
5675:
5670:
5650:
5645:
5640:
5595:
5585:
5545:
5474:
5444:
5439:
5434:
5429:
5424:
5419:
5374:
5344:
5249:
5217:
5212:
5192:
5182:
5177:
5162:
5157:
5058:
5053:
5022:
5002:
4997:
4987:
4982:
4861:
4814:
4774:
4429:
4424:
4419:
4414:
4399:
4390:
4385:
4380:
4365:
4323:
4318:
4308:
4303:
4286:
4281:
4276:
4271:
4266:
4261:
4256:
4251:
4246:
4182:
4155:
4150:
4145:
4120:
4115:
4052:
4047:
4042:
4032:
4027:
3980:
3975:
3970:
3960:
3955:
3938:
3933:
3928:
3918:
3913:
3898:
3893:
3888:
3878:
3873:
3868:
3851:
3846:
3841:
3792:
3760:
3755:
3750:
3733:
3728:
3723:
3718:
1489:
158:
5695:
3658:
2044:"Exon 6 of human Jagged-1 encodes an autonomously folding unit"
5187:
3799:
3787:
3782:
3777:
3767:
3740:
3708:
3239:
Oda T, Elkahloun AG, Meltzer PS, Chandrasekharappa SC (1997).
1758:
1605:
612:
2997:"The notch ligand JAGGED1 as a target for anti-tumor therapy"
1572:
mouse models with Jag1 mutations targeted to the portal vein
1516:, mesocardium, distal cardic outflow tract, major arteries,
1393:
in 1995. The structure of the JAG1 protein includes a small
1385:
that was able to activate notch receptors when the rat gene
1568:
for both Jag1 and Notch2 present with the ALGS phenotype.
1943:
Lindsell CE, Shawber CJ, Boulter J, Weinmaster G (1995).
928:
positive regulation of transcription by RNA polymerase II
1472:
has broad expression in many tissue types including the
414:
1432:
jagged protein. Human JAG1 is one of five ligands for
938:
negative regulation of endothelial cell differentiation
1337:) that interact with four receptors in the mammalian
579:
5791:
5765:
5733:
5493:
5287:
5036:
4720:
4443:
4103:
3701:
1243:
1222:
1196:
1175:
918:
positive regulation of myeloid cell differentiation
3617:GeneReviews/NCBI/UW/NIH entry on Alagille syndrome
2782:"Notch signaling in human development and disease"
1945:"Jagged: a mammalian ligand that activates Notch1"
1883:
1881:
1879:
1862:
1860:
1858:
858:positive regulation of osteoblast differentiation
361:
260:
2829:Morrissette JD, Colliton RP, Spinner NB (2001).
853:inner ear auditory receptor cell differentiation
833:negative regulation of stem cell differentiation
2307:
2305:
1938:
1936:
758:glomerular visceral epithelial cell development
748:negative regulation of fat cell differentiation
2995:Li D, Masiero M, Banham AH, Harris AL (2014).
2682:
2680:
1888:GRCm38: Ensembl release 89: ENSMUSG00000027276
983:negative regulation of Notch signaling pathway
923:positive regulation of Notch signaling pathway
5707:
3670:
2260:Jones EA, Clement-Jones M, Wilson DI (2000).
2255:
2253:
1636:(94%), while a smaller 2% have a mutation in
933:Notch signaling involved in heart development
773:negative regulation of neuron differentiation
8:
1464:studies have helped to demonstrate the role
1405:region containing a cystine-rich region, 16
973:cardiac epithelial to mesenchymal transition
1867:GRCh38: Ensembl release 89: ENSG00000101384
1650:mutation types include protein truncating (
948:negative regulation of cell-matrix adhesion
863:regulation of cell population proliferation
793:negative regulation of cell differentiation
5714:
5700:
5692:
3677:
3663:
3655:
3645:United States National Library of Medicine
2780:Penton AL, Leonard LD, Spinner NB (2012).
1990:
1988:
1008:
628:
402:
301:
198:
76:
3694:list of human clusters of differentiation
3629:at the U.S. National Library of Medicine
3591:
3540:
3468:
3432:
3389:
3346:
3336:
3293:
3183:
3063:
3022:
3012:
2971:
2930:
2846:
2805:
2712:
2660:
2611:
2601:
2552:
2503:
2454:
2378:
2353:Simon DP, Giordano TJ, Hammer GD (2012).
2329:
2285:
2233:
2184:
2143:
2059:
2042:Guarnaccia C, Pintar A, Pongor S (2004).
1960:
1820:
953:negative regulation of cell-cell adhesion
943:regulation of signaling receptor activity
828:neuronal stem cell population maintenance
3643:This article incorporates text from the
1441:cleavages leading to the original NOTCH
1333:) is one of five cell surface proteins (
1854:
1622:The Children's Hospital of Philadelphia
1512:expression is concentrated around the
31:
3366:"Human Ligands of the Notch Receptor"
1508:in the adult. In a developing embryo
958:negative regulation of cell migration
908:cardiac right ventricle morphogenesis
707:integral component of plasma membrane
366:
327:
322:
265:
224:
219:
7:
1453:Expression profile and mouse studies
913:morphogenesis of an epithelial sheet
763:endocardial cushion cell development
1560:deletions may show only a limited
1240:
1219:
1193:
1172:
1148:
1129:
1103:
1084:
1058:
1039:
838:multicellular organism development
584:
502:
440:
419:
25:
3622:OMIM entries on Alagille syndrome
1445:domain being trafficked into the
2226:10.1128/MCB.20.18.6913-6922.2000
1763:
893:endothelial cell differentiation
602:
595:
588:
350:
343:
337:
314:
249:
242:
236:
211:
40:
1389:encoding a protein homolog was
1381:JAG1 was first identified as a
1409:, a DSL domain, and finally a
783:pulmonary artery morphogenesis
687:integral component of membrane
613:More reference expression data
568:More reference expression data
1:
3496:Biochem. Biophys. Res. Commun
3382:10.1016/S0002-9440(10)65325-4
3295:10.1016/S1074-7613(00)80457-4
3065:10.1158/0008-5472.CAN-06-3700
2884:10.1016/S0016-5085(99)70017-X
2371:10.1158/1078-0432.CCR-11-2371
2331:10.1158/0008-5472.CAN-05-1069
2093:Biochem. Biophys. Res. Commun
2061:10.1016/j.febslet.2004.08.022
1626:National Institutes of Health
798:response to muramyl dipeptide
753:pulmonary valve morphogenesis
335:
234:
5835:Genes on human chromosome 20
3317:Proc. Natl. Acad. Sci. U.S.A
2798:10.1016/j.semcdb.2012.01.010
2582:Proc. Natl. Acad. Sci. U.S.A
1962:10.1016/0092-8674(95)90294-5
1428:is the human homolog of the
1424:The JAG1 protein encoded by
1365:has also been designated as
818:keratinocyte differentiation
788:cardiac septum morphogenesis
651:structural molecule activity
5850:Clusters of differentiation
3690:clusters of differentiation
1795:. Gene Wiki Review Series.
1682:mutations who present with
898:camera-type eye development
5866:
5792:Receptor on receiving cell
1805:10.1016/J.GENE.2015.10.065
1747:Cluster of differentiation
1564:(involving the eye), mice
1371:cluster of differentiation
968:aortic valve morphogenesis
878:animal organ morphogenesis
813:nervous system development
803:ciliary body morphogenesis
2973:10.1038/modpathol.3800785
1923:"Mouse PubMed Reference:"
1905:"Human PubMed Reference:"
1776:article was published in
1742:Conditional gene knockout
1570:Conditional gene knockout
1462:conditional gene knockout
1417:in length over 26 coding
1313:
1308:
1304:
1297:
1281:
1275:Chr 2: 136.92 β 136.96 Mb
1262:
1247:
1226:
1215:
1200:
1179:
1168:
1155:
1151:
1136:
1132:
1123:
1110:
1106:
1091:
1087:
1078:
1065:
1061:
1046:
1042:
1033:
1018:
1011:
1007:
991:
778:distal tubule development
768:loop of Henle development
631:
627:
610:
587:
578:
565:
514:
505:
452:
443:
413:
405:
401:
384:
371:
334:
313:
304:
300:
283:
270:
233:
210:
201:
197:
152:
149:
139:
132:
127:
84:
79:
62:
57:
52:
48:
39:
34:
3631:Medical Subject Headings
3425:10.1093/emboj/18.10.2803
3185:10.1074/jbc.271.51.32499
2186:10.1074/jbc.274.46.32961
1547:adrenocortical carcinoma
1268:Chr 20: 10.64 β 10.67 Mb
903:myoblast differentiation
743:T cell mediated immunity
5727:notch signaling pathway
3338:10.1073/pnas.95.17.9779
3014:10.3389/fonc.2014.00254
2603:10.1073/pnas.0709663105
1401:motif, proceeded by an
1339:Notch signaling pathway
883:cell fate determination
848:blood vessel remodeling
738:Notch signaling pathway
530:internal carotid artery
526:external carotid artery
29:Protein found in humans
3584:10.1084/jem.192.9.1365
3508:10.1006/bbrc.2000.2173
3257:10.1006/geno.1997.4820
3143:10.1006/mcne.1996.0040
2416:10.1242/dev.129.4.1075
2145:10.1074/jbc.M103473200
2105:10.1006/bbrc.2000.3469
1774:academic peer reviewed
1377:Structure and function
717:apical plasma membrane
666:growth factor activity
554:neural layer of retina
2786:Semin. Cell Dev. Biol
2456:10.1093/hmg/8.13.2443
1737:In situ hybridization
1458:In situ hybridization
888:inner ear development
476:palpebral conjunctiva
468:right coronary artery
227:Chromosome 20 (human)
3105:10.1055/s-2001-19036
2848:10.1093/hmg/10.4.405
2278:10.1136/jmg.37.9.658
1782:and can be cited as:
1608:, facial structure,
712:extracellular region
671:phospholipid binding
329:Chromosome 2 (mouse)
80:List of PDB id codes
53:Available structures
3627:JAG1+protein,+human
3329:1998PNAS...95.9779H
3131:Mol. Cell. Neurosci
2594:2008PNAS..105.1955H
1799:(1 Pt 3): 381β384.
1732:Tetralogy of fallot
1684:tetralogy of fallot
873:nephron development
808:aorta morphogenesis
702:apical part of cell
646:calcium ion binding
464:gingival epithelium
3647:, which is in the
3216:10.1038/ng0797-243
2923:10.1002/humu.21231
2751:10.1002/humu.20310
2653:10.1093/hmg/ddr575
2545:10.1242/dev.052118
2496:10.1242/dev.084871
2013:10.1038/ng0797-235
1727:Haploinsufficiency
1722:Autosomal dominant
1688:pulmonary stenosis
1668:haploinsufficiency
1590:autosomal dominant
1355:autosomal dominant
1113:ENSMUSG00000027276
843:cell communication
731:Biological process
680:Cellular component
639:Molecular function
538:epithelium of lens
5822:
5821:
5737:on signaling cell
5723:Signaling pathway
5689:
5688:
3637:Alagille syndrome
3178:(51): 32499β502.
2693:Am. J. Hum. Genet
1847:
1846:
1717:Alagille syndrome
1584:Disease phenotype
1566:haploinsufficient
1359:Alagille syndrome
1324:
1323:
1320:
1319:
1293:
1292:
1258:
1257:
1237:
1236:
1211:
1210:
1190:
1189:
1164:
1163:
1145:
1144:
1119:
1118:
1100:
1099:
1074:
1073:
1055:
1054:
1003:
1002:
692:adherens junction
623:
622:
619:
618:
574:
573:
561:
560:
499:
498:
397:
396:
296:
295:
123:
122:
119:
118:
63:Ortholog search:
16:(Redirected from
5857:
5716:
5709:
5702:
5693:
3679:
3672:
3665:
3656:
3605:
3595:
3562:
3544:
3519:
3490:
3472:
3446:
3436:
3403:
3393:
3360:
3350:
3340:
3307:
3297:
3268:
3235:
3197:
3187:
3162:
3124:
3093:Semin. Liver Dis
3078:
3077:
3067:
3043:
3037:
3036:
3026:
3016:
2992:
2986:
2985:
2975:
2951:
2945:
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2896:
2895:
2872:Gastroenterology
2867:
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2809:
2777:
2771:
2770:
2733:
2727:
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2573:
2567:
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2556:
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2517:
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2475:
2469:
2468:
2458:
2434:
2428:
2427:
2399:
2393:
2392:
2382:
2359:Clin. Cancer Res
2350:
2344:
2343:
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2309:
2300:
2299:
2289:
2257:
2248:
2247:
2237:
2205:
2199:
2198:
2188:
2164:
2158:
2157:
2147:
2123:
2117:
2116:
2088:
2082:
2081:
2063:
2039:
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1992:
1983:
1982:
1964:
1940:
1931:
1930:
1919:
1913:
1912:
1901:
1895:
1885:
1874:
1864:
1842:
1824:
1767:
1759:
1522:branchial arches
1514:pulmonary artery
1407:EGF-like repeats
1306:
1305:
1277:
1270:
1253:
1241:
1232:
1220:
1216:RefSeq (protein)
1206:
1194:
1185:
1173:
1149:
1130:
1104:
1085:
1059:
1040:
1009:
629:
615:
606:
599:
592:
585:
570:
518:secondary oocyte
510:
508:Top expressed in
503:
448:
446:Top expressed in
441:
420:
403:
393:
380:
369:
354:
347:
341:
330:
318:
302:
292:
279:
268:
253:
246:
240:
229:
215:
199:
193:
191:JAG1 - orthologs
144:
137:
114:
77:
71:
50:
49:
44:
32:
21:
5865:
5864:
5860:
5859:
5858:
5856:
5855:
5854:
5825:
5824:
5823:
5818:
5787:
5761:
5729:
5720:
5690:
5685:
5489:
5283:
5032:
4716:
4439:
4099:
3697:
3683:
3613:
3608:
3565:
3522:
3493:
3449:
3419:(10): 2803β11.
3406:
3363:
3323:(17): 9779β84.
3310:
3271:
3238:
3200:
3165:
3127:
3090:
3086:
3084:Further reading
3081:
3045:
3044:
3040:
2994:
2993:
2989:
2953:
2952:
2948:
2904:
2903:
2899:
2869:
2868:
2864:
2835:Hum. Mol. Genet
2828:
2827:
2823:
2779:
2778:
2774:
2735:
2734:
2730:
2686:
2685:
2678:
2641:Hum. Mol. Genet
2634:
2633:
2629:
2575:
2574:
2570:
2539:(23): 4061β72.
2526:
2525:
2521:
2490:(23): 4449β60.
2477:
2476:
2472:
2443:Hum. Mol. Genet
2436:
2435:
2431:
2401:
2400:
2396:
2352:
2351:
2347:
2311:
2310:
2303:
2259:
2258:
2251:
2220:(18): 6913β22.
2214:Mol. Cell. Biol
2207:
2206:
2202:
2179:(46): 32961β9.
2166:
2165:
2161:
2138:(28): 25753β8.
2125:
2124:
2120:
2090:
2089:
2085:
2054:(1β3): 156β60.
2041:
2040:
2036:
1994:
1993:
1986:
1942:
1941:
1934:
1921:
1920:
1916:
1903:
1902:
1898:
1886:
1877:
1865:
1856:
1852:
1843:
1784:
1783:
1768:
1755:
1712:Notch signaling
1708:
1697:More recently,
1614:vascular system
1586:
1455:
1379:
1315:View/Edit Mouse
1310:View/Edit Human
1273:
1266:
1263:Location (UCSC)
1249:
1228:
1202:
1181:
1094:ENSG00000101384
987:
726:
697:plasma membrane
675:
661:protein binding
611:
601:
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593:
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532:
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388:
375:
367:
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348:
328:
305:Gene location (
287:
274:
266:
256:
255:
254:
247:
225:
202:Gene location (
153:
140:
133:
86:
64:
30:
23:
22:
18:Jagged (ligand)
15:
12:
11:
5:
5863:
5861:
5853:
5852:
5847:
5842:
5837:
5827:
5826:
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3640:
3639:
3634:
3624:
3619:
3612:
3611:External links
3609:
3607:
3606:
3578:(9): 1365β72.
3563:
3520:
3491:
3463:(5): 394β400.
3447:
3404:
3361:
3308:
3269:
3236:
3198:
3163:
3125:
3087:
3085:
3082:
3080:
3079:
3058:(4): 1757β68.
3038:
2987:
2946:
2917:(5): 594β601.
2897:
2862:
2821:
2772:
2728:
2705:10.1086/301875
2676:
2647:(6): 1374β83.
2627:
2568:
2519:
2470:
2449:(13): 2443β9.
2429:
2410:(4): 1075β82.
2394:
2365:(9): 2452β64.
2345:
2324:(18): 8530β7.
2301:
2249:
2200:
2159:
2118:
2083:
2034:
1984:
1932:
1914:
1896:
1875:
1853:
1851:
1848:
1845:
1844:
1771:
1769:
1762:
1754:
1751:
1750:
1749:
1744:
1739:
1734:
1729:
1724:
1719:
1714:
1707:
1704:
1585:
1582:
1454:
1451:
1413:totaling 1218
1411:signal peptide
1378:
1375:
1322:
1321:
1318:
1317:
1312:
1302:
1301:
1295:
1294:
1291:
1290:
1288:
1286:
1279:
1278:
1271:
1264:
1260:
1259:
1256:
1255:
1245:
1244:
1238:
1235:
1234:
1224:
1223:
1217:
1213:
1212:
1209:
1208:
1198:
1197:
1191:
1188:
1187:
1177:
1176:
1170:
1166:
1165:
1162:
1161:
1153:
1152:
1146:
1143:
1142:
1134:
1133:
1127:
1121:
1120:
1117:
1116:
1108:
1107:
1101:
1098:
1097:
1089:
1088:
1082:
1076:
1075:
1072:
1071:
1063:
1062:
1056:
1053:
1052:
1044:
1043:
1037:
1031:
1030:
1025:
1020:
1016:
1015:
1005:
1004:
1001:
1000:
989:
988:
986:
985:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
734:
732:
728:
727:
725:
724:
719:
714:
709:
704:
699:
694:
689:
683:
681:
677:
676:
674:
673:
668:
663:
658:
653:
648:
642:
640:
636:
635:
625:
624:
621:
620:
617:
616:
608:
607:
582:
576:
575:
572:
571:
563:
562:
559:
558:
556:
555:
551:
547:
543:
539:
535:
531:
527:
523:
522:primary oocyte
519:
515:
512:
511:
500:
497:
496:
494:
493:
489:
485:
481:
477:
473:
469:
465:
461:
457:
453:
450:
449:
437:
436:
428:
417:
411:
410:
407:RNA expression
399:
398:
395:
394:
386:
382:
381:
373:
370:
365:
359:
358:
349:
342:
336:
332:
331:
326:
320:
319:
311:
310:
298:
297:
294:
293:
285:
281:
280:
272:
269:
264:
258:
257:
248:
241:
235:
231:
230:
223:
217:
216:
208:
207:
195:
194:
151:
147:
146:
138:
130:
129:
125:
124:
121:
120:
117:
116:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5862:
5851:
5848:
5846:
5843:
5841:
5838:
5836:
5833:
5832:
5830:
5815:
5812:
5810:
5807:
5805:
5802:
5800:
5797:
5796:
5794:
5790:
5784:
5781:
5779:
5776:
5773:
5772:
5770:
5768:
5764:
5758:
5755:
5753:
5750:
5748:
5745:
5742:
5741:
5739:
5736:
5732:
5728:
5724:
5717:
5712:
5710:
5705:
5703:
5698:
5697:
5694:
5682:
5679:
5677:
5674:
5672:
5669:
5667:
5664:
5662:
5659:
5657:
5654:
5652:
5649:
5647:
5644:
5642:
5639:
5637:
5634:
5632:
5629:
5627:
5624:
5622:
5619:
5617:
5614:
5612:
5609:
5607:
5604:
5602:
5599:
5597:
5594:
5592:
5589:
5587:
5584:
5582:
5579:
5577:
5574:
5572:
5569:
5567:
5564:
5562:
5559:
5557:
5554:
5552:
5549:
5547:
5544:
5542:
5539:
5537:
5534:
5532:
5529:
5527:
5524:
5522:
5519:
5517:
5514:
5512:
5509:
5507:
5504:
5502:
5499:
5498:
5496:
5492:
5486:
5483:
5481:
5478:
5476:
5473:
5471:
5468:
5466:
5463:
5461:
5458:
5456:
5453:
5451:
5448:
5446:
5443:
5441:
5438:
5436:
5433:
5431:
5428:
5426:
5423:
5421:
5418:
5416:
5413:
5411:
5408:
5406:
5403:
5401:
5398:
5396:
5393:
5391:
5388:
5386:
5383:
5381:
5378:
5376:
5373:
5371:
5368:
5366:
5363:
5361:
5358:
5356:
5353:
5351:
5348:
5346:
5343:
5341:
5338:
5336:
5333:
5331:
5328:
5326:
5323:
5321:
5318:
5316:
5313:
5311:
5308:
5306:
5303:
5301:
5298:
5296:
5293:
5292:
5290:
5286:
5280:
5277:
5275:
5271:
5268:
5266:
5263:
5261:
5258:
5256:
5253:
5251:
5248:
5246:
5243:
5241:
5238:
5236:
5233:
5231:
5228:
5226:
5223:
5219:
5216:
5214:
5211:
5210:
5209:
5206:
5204:
5201:
5199:
5196:
5194:
5191:
5189:
5186:
5184:
5181:
5179:
5176:
5174:
5171:
5169:
5166:
5164:
5161:
5159:
5156:
5154:
5151:
5149:
5146:
5144:
5141:
5138:
5135:
5133:
5129:
5126:
5124:
5121:
5117:
5114:
5112:
5109:
5108:
5107:
5104:
5102:
5099:
5095:
5092:
5090:
5087:
5086:
5085:
5082:
5080:
5077:
5075:
5072:
5070:
5067:
5065:
5062:
5060:
5057:
5055:
5052:
5050:
5047:
5045:
5042:
5041:
5039:
5035:
5029:
5026:
5024:
5021:
5019:
5016:
5014:
5011:
5009:
5006:
5004:
5001:
4999:
4996:
4994:
4991:
4989:
4986:
4984:
4981:
4979:
4976:
4974:
4971:
4969:
4966:
4964:
4961:
4959:
4956:
4954:
4951:
4949:
4946:
4942:
4939:
4937:
4934:
4933:
4932:
4929:
4927:
4924:
4922:
4919:
4917:
4914:
4910:
4907:
4905:
4902:
4900:
4897:
4896:
4895:
4892:
4890:
4887:
4885:
4882:
4880:
4877:
4875:
4872:
4868:
4865:
4863:
4860:
4859:
4858:
4855:
4853:
4850:
4848:
4845:
4843:
4840:
4838:
4835:
4833:
4830:
4828:
4825:
4821:
4818:
4816:
4813:
4812:
4811:
4808:
4805:
4802:
4800:
4797:
4795:
4792:
4790:
4787:
4785:
4781:
4778:
4776:
4773:
4769:
4766:
4764:
4761:
4759:
4756:
4755:
4754:
4751:
4749:
4746:
4744:
4741:
4739:
4736:
4734:
4731:
4729:
4726:
4725:
4723:
4719:
4713:
4710:
4708:
4705:
4703:
4700:
4698:
4695:
4693:
4690:
4688:
4685:
4683:
4680:
4678:
4675:
4673:
4670:
4668:
4665:
4663:
4660:
4658:
4655:
4653:
4650:
4648:
4645:
4643:
4640:
4638:
4635:
4633:
4630:
4628:
4625:
4623:
4620:
4618:
4615:
4613:
4610:
4608:
4605:
4603:
4600:
4598:
4595:
4593:
4590:
4586:
4583:
4581:
4578:
4577:
4576:
4573:
4569:
4566:
4564:
4561:
4560:
4559:
4556:
4554:
4551:
4549:
4546:
4544:
4541:
4539:
4536:
4534:
4531:
4529:
4526:
4524:
4521:
4519:
4516:
4514:
4511:
4509:
4506:
4504:
4501:
4499:
4496:
4492:
4489:
4487:
4484:
4483:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4457:
4454:
4452:
4449:
4448:
4446:
4442:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4392:
4389:
4387:
4384:
4382:
4379:
4377:
4374:
4372:
4369:
4367:
4364:
4360:
4357:
4355:
4352:
4350:
4347:
4345:
4342:
4340:
4337:
4335:
4332:
4331:
4330:
4327:
4325:
4322:
4320:
4317:
4315:
4312:
4310:
4307:
4305:
4302:
4298:
4295:
4293:
4290:
4289:
4288:
4285:
4283:
4280:
4278:
4275:
4273:
4270:
4268:
4265:
4263:
4260:
4258:
4255:
4253:
4250:
4248:
4245:
4241:
4238:
4236:
4233:
4231:
4228:
4226:
4223:
4221:
4218:
4216:
4213:
4212:
4211:
4208:
4204:
4201:
4199:
4196:
4194:
4191:
4190:
4189:
4186:
4184:
4181:
4177:
4174:
4172:
4169:
4167:
4164:
4163:
4162:
4159:
4157:
4154:
4152:
4149:
4147:
4144:
4142:
4139:
4137:
4134:
4132:
4129:
4127:
4124:
4122:
4119:
4117:
4114:
4112:
4109:
4108:
4106:
4102:
4096:
4093:
4089:
4086:
4084:
4081:
4079:
4076:
4074:
4071:
4069:
4066:
4064:
4061:
4060:
4059:
4056:
4054:
4051:
4049:
4046:
4044:
4041:
4039:
4036:
4034:
4031:
4029:
4026:
4022:
4019:
4017:
4014:
4012:
4009:
4007:
4004:
4003:
4002:
3999:
3997:
3994:
3992:
3989:
3987:
3984:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3950:
3947:
3945:
3942:
3941:
3940:
3937:
3935:
3932:
3930:
3927:
3925:
3922:
3920:
3917:
3915:
3912:
3910:
3907:
3905:
3902:
3900:
3897:
3895:
3892:
3890:
3887:
3885:
3882:
3880:
3877:
3875:
3872:
3870:
3867:
3863:
3860:
3858:
3855:
3854:
3853:
3850:
3848:
3845:
3843:
3840:
3838:
3835:
3831:
3828:
3826:
3823:
3821:
3818:
3816:
3813:
3812:
3811:
3808:
3806:
3803:
3801:
3798:
3794:
3791:
3790:
3789:
3786:
3784:
3781:
3779:
3776:
3774:
3771:
3769:
3766:
3762:
3759:
3757:
3754:
3752:
3749:
3748:
3747:
3744:
3742:
3739:
3735:
3732:
3730:
3727:
3725:
3722:
3720:
3717:
3715:
3712:
3711:
3710:
3707:
3706:
3704:
3700:
3695:
3691:
3687:
3680:
3675:
3673:
3668:
3666:
3661:
3660:
3657:
3653:
3652:
3650:
3649:public domain
3646:
3638:
3635:
3632:
3628:
3625:
3623:
3620:
3618:
3615:
3614:
3610:
3603:
3599:
3594:
3589:
3585:
3581:
3577:
3573:
3569:
3564:
3560:
3556:
3552:
3548:
3543:
3538:
3535:(5): 408β16.
3534:
3530:
3526:
3521:
3517:
3513:
3509:
3505:
3501:
3497:
3492:
3488:
3484:
3480:
3476:
3471:
3466:
3462:
3458:
3454:
3448:
3444:
3440:
3435:
3430:
3426:
3422:
3418:
3414:
3410:
3405:
3401:
3397:
3392:
3387:
3383:
3379:
3376:(3): 785β94.
3375:
3371:
3370:Am. J. Pathol
3367:
3362:
3358:
3354:
3349:
3344:
3339:
3334:
3330:
3326:
3322:
3318:
3314:
3309:
3305:
3301:
3296:
3291:
3287:
3283:
3279:
3275:
3274:Torok-Storb B
3270:
3266:
3262:
3258:
3254:
3250:
3246:
3242:
3237:
3233:
3229:
3225:
3221:
3217:
3213:
3210:(3): 243β51.
3209:
3205:
3199:
3195:
3191:
3186:
3181:
3177:
3173:
3172:J. Biol. Chem
3169:
3164:
3160:
3156:
3152:
3148:
3144:
3140:
3136:
3132:
3126:
3122:
3118:
3114:
3110:
3106:
3102:
3099:(4): 525β34.
3098:
3094:
3089:
3088:
3083:
3075:
3071:
3066:
3061:
3057:
3053:
3049:
3042:
3039:
3034:
3030:
3025:
3020:
3015:
3010:
3006:
3002:
2998:
2991:
2988:
2983:
2979:
2974:
2969:
2966:(6): 685β93.
2965:
2961:
2957:
2950:
2947:
2942:
2938:
2933:
2928:
2924:
2920:
2916:
2912:
2908:
2901:
2898:
2893:
2889:
2885:
2881:
2878:(5): 1141β8.
2877:
2873:
2866:
2863:
2858:
2854:
2849:
2844:
2841:(4): 405β13.
2840:
2836:
2832:
2825:
2822:
2817:
2813:
2808:
2803:
2799:
2795:
2791:
2787:
2783:
2776:
2773:
2768:
2764:
2760:
2756:
2752:
2748:
2745:(5): 436β43.
2744:
2740:
2732:
2729:
2724:
2720:
2715:
2710:
2706:
2702:
2699:(6): 1361β9.
2698:
2694:
2690:
2683:
2681:
2677:
2672:
2668:
2663:
2658:
2654:
2650:
2646:
2642:
2638:
2631:
2628:
2623:
2619:
2614:
2609:
2604:
2599:
2595:
2591:
2588:(6): 1955β9.
2587:
2583:
2579:
2572:
2569:
2564:
2560:
2555:
2550:
2546:
2542:
2538:
2534:
2530:
2523:
2520:
2515:
2511:
2506:
2501:
2497:
2493:
2489:
2485:
2481:
2474:
2471:
2466:
2462:
2457:
2452:
2448:
2444:
2440:
2433:
2430:
2425:
2421:
2417:
2413:
2409:
2405:
2398:
2395:
2390:
2386:
2381:
2376:
2372:
2368:
2364:
2360:
2356:
2349:
2346:
2341:
2337:
2332:
2327:
2323:
2319:
2315:
2308:
2306:
2302:
2297:
2293:
2288:
2283:
2279:
2275:
2272:(9): 658β62.
2271:
2267:
2266:J. Med. Genet
2263:
2256:
2254:
2250:
2245:
2241:
2236:
2231:
2227:
2223:
2219:
2215:
2211:
2204:
2201:
2196:
2192:
2187:
2182:
2178:
2174:
2173:J. Biol. Chem
2170:
2163:
2160:
2155:
2151:
2146:
2141:
2137:
2133:
2132:J. Biol. Chem
2129:
2122:
2119:
2114:
2110:
2106:
2102:
2098:
2094:
2087:
2084:
2079:
2075:
2071:
2067:
2062:
2057:
2053:
2049:
2045:
2038:
2035:
2030:
2026:
2022:
2018:
2014:
2010:
2007:(3): 235β42.
2006:
2002:
1998:
1991:
1989:
1985:
1980:
1976:
1972:
1968:
1963:
1958:
1955:(6): 909β17.
1954:
1950:
1946:
1939:
1937:
1933:
1928:
1924:
1918:
1915:
1910:
1906:
1900:
1897:
1893:
1889:
1884:
1882:
1880:
1876:
1872:
1868:
1863:
1861:
1859:
1855:
1849:
1840:
1836:
1832:
1828:
1823:
1818:
1814:
1810:
1806:
1802:
1798:
1794:
1793:
1788:
1781:
1780:
1775:
1770:
1766:
1761:
1760:
1757:
1752:
1748:
1745:
1743:
1740:
1738:
1735:
1733:
1730:
1728:
1725:
1723:
1720:
1718:
1715:
1713:
1710:
1709:
1705:
1703:
1700:
1695:
1693:
1689:
1685:
1681:
1677:
1673:
1669:
1665:
1661:
1657:
1653:
1649:
1645:
1641:
1640:
1635:
1631:
1627:
1623:
1619:
1615:
1611:
1607:
1603:
1599:
1595:
1591:
1583:
1581:
1579:
1575:
1571:
1567:
1563:
1559:
1555:
1550:
1548:
1544:
1543:breast cancer
1539:
1536:. Generally,
1535:
1531:
1527:
1523:
1519:
1515:
1511:
1507:
1503:
1499:
1495:
1491:
1487:
1483:
1479:
1475:
1471:
1467:
1463:
1459:
1452:
1450:
1448:
1444:
1443:intracellular
1440:
1435:
1431:
1427:
1422:
1420:
1416:
1412:
1408:
1404:
1403:extracellular
1400:
1399:transmembrane
1397:component, a
1396:
1395:intracellular
1392:
1388:
1384:
1376:
1374:
1372:
1368:
1364:
1360:
1356:
1352:
1348:
1347:chromosome 20
1344:
1340:
1336:
1332:
1328:
1316:
1311:
1307:
1303:
1300:
1296:
1289:
1287:
1284:
1280:
1276:
1272:
1269:
1265:
1261:
1254:
1252:
1246:
1242:
1239:
1233:
1231:
1225:
1221:
1218:
1214:
1207:
1205:
1199:
1195:
1192:
1186:
1184:
1178:
1174:
1171:
1169:RefSeq (mRNA)
1167:
1160:
1159:
1154:
1150:
1147:
1141:
1140:
1135:
1131:
1128:
1126:
1122:
1115:
1114:
1109:
1105:
1102:
1096:
1095:
1090:
1086:
1083:
1081:
1077:
1070:
1069:
1064:
1060:
1057:
1051:
1050:
1045:
1041:
1038:
1036:
1032:
1029:
1026:
1024:
1021:
1017:
1014:
1010:
1006:
999:
995:
990:
984:
981:
979:
976:
974:
971:
969:
966:
964:
961:
959:
956:
954:
951:
949:
946:
944:
941:
939:
936:
934:
931:
929:
926:
924:
921:
919:
916:
914:
911:
909:
906:
904:
901:
899:
896:
894:
891:
889:
886:
884:
881:
879:
876:
874:
871:
869:
866:
864:
861:
859:
856:
854:
851:
849:
846:
844:
841:
839:
836:
834:
831:
829:
826:
824:
821:
819:
816:
814:
811:
809:
806:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
735:
733:
730:
729:
723:
720:
718:
715:
713:
710:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
684:
682:
679:
678:
672:
669:
667:
664:
662:
659:
657:
656:Notch binding
654:
652:
649:
647:
644:
643:
641:
638:
637:
634:
633:Gene ontology
630:
626:
614:
609:
605:
598:
591:
586:
583:
581:
577:
569:
564:
553:
549:
545:
542:hair follicle
541:
537:
533:
529:
525:
521:
517:
516:
513:
509:
504:
501:
492:hair follicle
491:
487:
483:
479:
475:
471:
467:
463:
459:
456:skin of thigh
455:
454:
451:
447:
442:
439:
438:
435:
433:
429:
427:
426:
422:
421:
418:
416:
412:
408:
404:
400:
392:
387:
383:
379:
374:
364:
360:
353:
346:
340:
333:
325:
321:
317:
312:
308:
303:
299:
291:
286:
282:
278:
273:
263:
259:
252:
245:
239:
232:
228:
222:
218:
214:
209:
205:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
148:
143:
136:
131:
126:
115:
113:
109:
105:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
27:
19:
5777:
5660:
5207:
5127:
5105:
5083:
4930:
4893:
4856:
4809:
4779:
4752:
4574:
4480:
4328:
4057:
3809:
3642:
3641:
3575:
3571:
3532:
3528:
3502:(3): 853β9.
3499:
3495:
3460:
3456:
3416:
3412:
3373:
3369:
3320:
3316:
3288:(1): 43β55.
3285:
3281:
3251:(3): 376β9.
3248:
3244:
3207:
3203:
3175:
3171:
3137:(1): 14β27.
3134:
3130:
3096:
3092:
3055:
3051:
3041:
3004:
3000:
2990:
2963:
2959:
2949:
2914:
2910:
2900:
2875:
2871:
2865:
2838:
2834:
2824:
2792:(4): 450β7.
2789:
2785:
2775:
2742:
2738:
2731:
2696:
2692:
2644:
2640:
2630:
2585:
2581:
2571:
2536:
2532:
2522:
2487:
2483:
2473:
2446:
2442:
2432:
2407:
2403:
2397:
2362:
2358:
2348:
2321:
2317:
2269:
2265:
2217:
2213:
2203:
2176:
2172:
2162:
2135:
2131:
2121:
2099:(1): 385β9.
2096:
2092:
2086:
2051:
2047:
2037:
2004:
2000:
1952:
1948:
1926:
1917:
1908:
1899:
1796:
1790:
1778:
1777:
1756:
1698:
1696:
1691:
1679:
1675:
1671:
1647:
1643:
1637:
1633:
1617:
1587:
1558:heterozygous
1551:
1537:
1509:
1469:
1465:
1456:
1425:
1423:
1386:
1380:
1366:
1362:
1350:
1330:
1326:
1325:
1248:
1227:
1201:
1180:
1156:
1137:
1111:
1092:
1066:
1047:
1027:
1022:
868:angiogenesis
430:
423:
389:136,958,564
376:136,923,376
150:External IDs
85:
26:
3572:J. Exp. Med
3001:Front Oncol
2960:Mod. Pathol
2533:Development
2484:Development
2404:Development
1652:splice site
1588:ALGS is an
1578:endothelium
1530:portal vein
1518:metanephros
1439:proteolytic
1415:amino acids
1343:proteolytic
963:hemopoiesis
484:oral cavity
472:human penis
460:skin of hip
368:2 F3|2
288:10,673,999
275:10,637,684
128:Identifiers
5829:Categories
3692:(see also
3529:Hum. Mutat
3457:Hum. Mutat
3204:Nat. Genet
3052:Cancer Res
2911:Hum. Mutat
2739:Hum. Mutat
2318:Cancer Res
2001:Nat. Genet
1894:, May 2017
1873:, May 2017
1850:References
1694:mutation.
1656:frameshift
1646:mutation.
1574:mesenchyme
1554:homozygous
1549:patients.
1506:leucocytes
1430:Drosophila
550:belly cord
434:(ortholog)
171:HomoloGene
2048:FEBS Lett
1839:Q28606584
1813:0378-1119
1562:phenotype
1434:receptors
1357:disorder
1251:NP_038850
1230:NP_000205
1204:NM_013822
1183:NM_000214
1013:Orthologs
534:epidermis
179:GeneCards
5735:Receptor
3686:Proteins
3602:11067884
3559:22168402
3551:11058898
3516:10679295
3487:45123109
3479:10533065
3443:10329626
3400:10079256
3282:Immunity
3276:(1998).
3245:Genomics
3121:46554750
3113:11745040
3074:17308118
3033:25309874
2982:17507991
2941:20437614
2892:10220506
2857:11157803
2816:22306179
2767:45080348
2759:16575836
2671:22156581
2622:18245384
2563:21062863
2514:23095891
2465:10556292
2424:11861489
2389:22427350
2340:16166334
2296:10978356
2244:10958687
2195:10551863
2154:11346656
2113:11006133
2078:34651925
2070:15358557
1979:11720367
1890:–
1869:–
1835:Wikidata
1831:26548814
1706:See also
1664:missense
1660:nonsense
1630:mutation
1624:and the
1602:skeleton
1526:pancreas
1486:prostate
1482:placenta
1474:pancreas
1299:Wikidata
992:Sources:
722:membrane
5814:Notch 4
5809:Notch 3
5804:Notch 2
5799:Notch 1
5494:301β350
5288:251β300
5240:CD240CE
5037:201β250
4721:151β200
4444:101β150
3593:2193352
3434:1171361
3391:1866435
3357:9707552
3325:Bibcode
3304:9462510
3265:9268641
3232:8794354
3224:9207788
3194:8955070
3159:8058790
3151:8923452
3024:4174884
3007:: 254.
2932:2914103
2807:3638987
2723:9585603
2714:1377154
2662:3465692
2613:2538864
2590:Bibcode
2554:2976287
2505:3509736
2380:3848076
2287:1734694
2029:5775213
2021:9207787
1971:7697721
1892:Ensembl
1871:Ensembl
1822:4673022
1644:de novo
1610:kidneys
1534:otocyst
1447:nucleus
1335:ligands
1327:Jagged1
1125:UniProt
1080:Ensembl
1019:Species
998:QuickGO
480:urethra
409:pattern
267:20p12.2
167:1095416
135:Aliases
5774:Jagged
5767:Ligand
5501:CD300A
5460:CDw293
5245:CD240D
5106:CD213a
5084:CDw210
5049:CD202b
5023:CDw199
5018:CDw198
4672:CD140b
4104:51β100
3633:(MeSH)
3600:
3590:
3557:
3549:
3514:
3485:
3477:
3441:
3431:
3413:EMBO J
3398:
3388:
3355:
3345:
3302:
3263:
3230:
3222:
3192:
3157:
3149:
3119:
3111:
3072:
3031:
3021:
2980:
2939:
2929:
2890:
2855:
2814:
2804:
2765:
2757:
2721:
2711:
2669:
2659:
2620:
2610:
2561:
2551:
2512:
2502:
2463:
2422:
2387:
2377:
2338:
2294:
2284:
2242:
2232:
2193:
2152:
2111:
2076:
2068:
2027:
2019:
1977:
1969:
1837:
1829:
1819:
1811:
1658:, and
1639:NOTCH2
1532:, and
1528:, the
1504:, and
1502:testis
1498:thymus
1494:kidney
1391:cloned
1387:Jagged
1383:ligand
1373:339).
1349:, the
1285:search
1283:PubMed
1158:Q9QXX0
1139:P78504
1035:Entrez
580:BioGPS
159:601920
5743:Delta
5681:CD350
5676:CD349
5671:CD344
5666:CD340
5661:CD339
5656:CD338
5651:CD337
5646:CD336
5641:CD335
5636:CD334
5631:CD333
5626:CD332
5621:CD331
5616:CD329
5611:CD328
5606:CD327
5601:CD326
5596:CD325
5591:CD324
5586:CD322
5581:CD321
5576:CD320
5571:CD318
5566:CD317
5561:CD316
5556:CD315
5551:CD314
5546:CD312
5541:CD309
5536:CD307
5531:CD306
5526:CD305
5521:CD304
5516:CD303
5511:CD302
5506:CD301
5485:CD299
5480:CD298
5475:CD297
5470:CD295
5465:CD294
5455:CD292
5450:CD290
5445:CD289
5440:CD288
5435:CD286
5430:CD284
5425:CD283
5420:CD282
5415:CD281
5410:CD280
5405:CD279
5400:CD278
5395:CD276
5390:CD275
5385:CD274
5380:CD273
5375:CD272
5370:CD271
5365:CD269
5360:CD268
5355:CD267
5350:CD266
5345:CD265
5340:CD264
5335:CD263
5330:CD262
5325:CD261
5320:CD258
5315:CD257
5310:CD256
5305:CD254
5300:CD253
5295:CD252
5279:CD249
5274:CD248
5270:CD247
5265:CD246
5260:CD244
5255:CD243
5250:CD241
5235:CD239
5230:CD238
5225:CD236
5208:CD235
5203:CD234
5198:CD233
5193:CD230
5188:CD229
5183:CD228
5178:CD227
5173:CD226
5168:CD225
5163:CD224
5158:CD223
5153:CD222
5148:CD221
5143:CD220
5128:CD218
5123:CD217
5101:CD212
5079:CD209
5074:CD208
5069:CD207
5064:CD206
5059:CD205
5054:CD204
5044:CD201
5028:CD200
5013:CD197
5008:CD196
5003:CD195
4998:CD194
4993:CD193
4988:CD192
4983:CD191
4978:CD186
4973:CD185
4968:CD184
4963:CD183
4958:CD182
4953:CD181
4948:CD180
4931:CD179
4926:CD178
4921:CD177
4916:CD174
4894:CD172
4889:CD171
4884:CD170
4879:CD169
4874:CD168
4857:CD167
4852:CD166
4847:CD164
4842:CD163
4837:CD162
4832:CD161
4827:CD160
4810:CD159
4780:CD158
4775:CD157
4753:CD156
4748:CD155
4743:CD154
4738:CD153
4733:CD152
4728:CD151
4712:CD150
4707:CD148
4702:CD147
4697:CD146
4692:CD144
4687:CD143
4682:CD142
4677:CD141
4667:CD138
4662:CD137
4657:CD136
4652:CD135
4647:CD134
4642:CD133
4637:CD132
4632:CD131
4627:CD130
4622:CD129
4617:CD127
4612:CD126
4607:CD125
4602:CD124
4597:CD123
4592:CD122
4575:CD121
4558:CD120
4553:CD119
4548:CD118
4543:CD117
4538:CD116
4533:CD115
4528:CD114
4523:CD113
4518:CD112
4513:CD111
4508:CD110
4503:CD109
4498:CD108
4481:CD107
4476:CD106
4471:CD105
4466:CD104
4461:CD103
4456:CD102
4451:CD101
4435:CD100
3555:S2CID
3483:S2CID
3348:21413
3228:S2CID
3155:S2CID
3117:S2CID
2763:S2CID
2235:88767
2074:S2CID
2025:S2CID
1975:S2CID
1779:Gene
1753:Notes
1598:heart
1594:liver
1478:heart
1419:exons
1367:CD339
1068:16449
1028:Mouse
1023:Human
994:Amigo
546:molar
488:vulva
432:Mouse
425:Human
372:Start
307:Mouse
271:Start
204:Human
5783:JAG2
5778:JAG1
5757:DLL4
5752:DLL3
5747:DLL1
4430:CD99
4425:CD98
4420:CD97
4415:CD96
4410:CD95
4405:CD94
4400:CD93
4395:CD92
4391:CD91
4386:CD90
4381:CD89
4376:CD88
4371:CD87
4366:CD86
4329:CD85
4324:CD84
4319:CD83
4314:CD82
4309:CD81
4304:CD80
4287:CD79
4282:CD78
4277:CD74
4272:CD73
4267:CD72
4262:CD71
4257:CD70
4252:CD69
4247:CD68
4210:CD66
4188:CD64
4183:CD63
4161:CD62
4156:CD61
4151:CD59
4146:CD58
4141:CD57
4136:CD56
4131:CD55
4126:CD54
4121:CD53
4116:CD52
4111:CD51
4095:CD50
4058:CD49
4053:CD48
4048:CD47
4043:CD46
4038:CD45
4033:CD44
4028:CD43
4001:CD42
3996:CD41
3991:CD40
3986:CD39
3981:CD38
3976:CD37
3971:CD36
3966:CD35
3961:CD34
3956:CD33
3939:CD32
3934:CD31
3929:CD30
3924:CD29
3919:CD28
3914:CD27
3909:CD26
3904:CD25
3899:CD24
3894:CD23
3889:CD22
3884:CD21
3879:CD20
3874:CD19
3869:CD18
3852:CD16
3847:CD15
3842:CD14
3837:CD13
3810:CD11
3805:CD10
3702:1β50
3598:PMID
3547:PMID
3512:PMID
3475:PMID
3439:PMID
3396:PMID
3353:PMID
3300:PMID
3261:PMID
3220:PMID
3190:PMID
3147:PMID
3109:PMID
3070:PMID
3029:PMID
2978:PMID
2937:PMID
2888:PMID
2853:PMID
2812:PMID
2755:PMID
2719:PMID
2667:PMID
2618:PMID
2559:PMID
2510:PMID
2461:PMID
2420:PMID
2385:PMID
2336:PMID
2292:PMID
2240:PMID
2191:PMID
2150:PMID
2109:PMID
2066:PMID
2017:PMID
1967:PMID
1949:Cell
1827:PMID
1809:ISSN
1792:Gene
1699:JAG1
1692:JAG1
1680:JAG1
1676:JAG1
1672:JAG1
1670:for
1648:JAG1
1634:JAG1
1618:JAG1
1612:and
1545:and
1538:JAG1
1510:JAG1
1490:lung
1470:JAG1
1466:JAG1
1460:and
1426:JAG1
1363:JAG1
1351:JAG1
1331:JAG1
415:Bgee
363:Band
324:Chr.
262:Band
221:Chr.
183:JAG1
155:OMIM
142:JAG1
112:5BO1
108:4XI7
104:4CC1
100:4CC0
96:4CBZ
92:2VJ2
88:2KB9
69:RCSB
66:PDBe
35:JAG1
3800:CD9
3788:CD8
3783:CD7
3778:CD6
3773:CD5
3768:CD4
3746:CD3
3741:CD2
3714:a-c
3709:CD1
3588:PMC
3580:doi
3576:192
3537:doi
3504:doi
3500:268
3465:doi
3429:PMC
3421:doi
3386:PMC
3378:doi
3374:154
3343:PMC
3333:doi
3290:doi
3253:doi
3212:doi
3180:doi
3176:271
3139:doi
3101:doi
3060:doi
3019:PMC
3009:doi
2968:doi
2927:PMC
2919:doi
2880:doi
2876:116
2843:doi
2802:PMC
2794:doi
2747:doi
2709:PMC
2701:doi
2657:PMC
2649:doi
2608:PMC
2598:doi
2586:105
2549:PMC
2541:doi
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