432:
In 2014 Osbourn was elected to join the board of the BioIndustry
Association, becoming Chair in 2016; and in this role she has been working to support the development of the biotechnology sector in the UK. She also does this through her roles as a Director of Babraham Bioscience Technologies and as a
788:
Vaughan, Tristan J.; Williams, Andrew J.; Pritchard, Kevin; Osbourn, Jane K.; Pope, Anthony R.; Earnshaw, John C.; McCafferty, John; Hodits, Regina A.; Wilton, Jane; Johnson, Kevin S. (31 March 1996). "Human
Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display
427:
In 2016, Fierce Pharma’s “Fierce Women in
Biopharma” recognised her as one of 15 women in the global industry noteworthy for their leadership, providing mentorship and helping increase opportunities for women in science. FierceBiotech and its family of publications provide end-to-end coverage of
416:
Her early interest in science has grown into a passion for science education, supporting and championing life science education programmes and she is established as an advisor and mentor to many young researchers in the life science sector. She has been acknowledged by a number of different
509:. Jane’s leadership in UK life sciences includes championing the biotech sector through her position as chair of the BIA and contributing to the growth of the UK’s scientific ecosystem. I would also like to recognise her authentic commitment to building skills through
477:
and in the
University – and what happened was a condensation of that focus… Once we decided to make phage display work, we set some really tough goals and then just got on with it." To recognise Jane’s contribution to the prize, she, along with David Chiswell and
396:
CAT was acquired by AstraZeneca in 2006 and in the following year was merged with a US-based company called MedImmune to form AstraZeneca’s global biologics R&D arm. During this time
Osbourn began to speak about opportunities for diversity in science.
680:
Osbourn, J. K.; Watts, J. W.; Beachy, R. N.; Wilson, T. M. (30 September 1989). "Evidence that nucleocapsid disassembly and a later step in virus replication are inhibited in transgenic tobacco protoplasts expressing TMV coat protein".
287:, United States, undertaking research directed towards clarification of the sequence elements responsible for the translational enhancement effect conferred by the 5' untranslated region of Tobacco Mosaic Virus known as omega.
436:
Osbourn has presented at a number of parliamentary Select
Committees. At the Business, Innovation and Skills Committee, on Tuesday 13 May 2014, she gave evidence on behalf of AstraZeneca as it faced a potential takeover from
421:
She has been recognised in two BioBeat Movers and
Shakers lists - BioBeat 50 Movers and Shakers in BioBusiness 2014 and 2016. BioBeat is an organisation that connects entrepreneurs with the leaders in biotech.
407:
In
February 2019, it was announced that Osbourn would be leaving AstraZeneca. Since November 2019, Osbourn has been Chief Scientific Office of antibody therapeutics discovery company Alchemab Therapeutics.
1816:
1938:
752:
1834:
470:
had founded
Cambridge Antibody Technology to exploit this science. Osbourn says of this time, "There was a cohort of really able intellect in Cambridge – in CAT and other companies, in the
424:
In 2016 she was recognised in the PharmaVoice 100 researchers and scientists. PharmaVOICE is a resource for life-sciences executives and other healthcare-service related professionals
1967:
290:
Osbourn then moved into medical research through a
British Heart Foundation Post-Doctoral Fellowship at the Department of Medicine at Addenbrooke's Hospital in Cambridge.
510:
332:
A novel in vivo method for isolating antibodies from a phage display library by neuronal retrograde transport selectively yields antibodies against p75(NTR.), MAbs, 2013
119:
322:
A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy, Cancer Cell, 2019
1977:
1920:
975:"A novel in vivo method for isolating antibodies from a phage display library by neuronal retrograde transport selectively yields antibodies against p75(NTR.)"
734:
493:, said of the award "On behalf of AstraZeneca, I am delighted to congratulate Dr Jane Osbourn for her award of an OBE in recognition of her services to human
1609:
1863:"AZ and MedImmune to spearhead biotech judging | Business Weekly | Technology News | Business news | Cambridge and the East of England"
253:
717:"Complementation of coat protein-defective TMV mutants in transgenic tobacco plants expressing TMV coat protein | Jane K. Osbourn | Request PDF"
1489:
29:
277:
Evidence that nucleocapsid disassembly and a later step in virus replication are inhibited in transgenic tobacco protoplasts expressing TMV coat protein
150:
Evidence that nucleocapsid disassembly and a later step in virus replication are inhibited in transgenic tobacco protoplasts expressing TMV coat protein
877:"A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy"
471:
1106:
Shanahan, CM (1999). "Aquaporin-1 is expressed by vascular smooth muscle cells and mediates rapid water transport across vascular cell membranes".
1862:
1987:
1507:
347:
Aquaporin-1 is expressed by vascular smooth muscle cells and mediates rapid water transport across vascular cell membranes, J Vasc Res, 1999
1798:
1083:
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On 7 June 2019 she was awarded an OBE for services to Human Monoclonal Antibody Drug Research and Development and Biotechnology. CEO of
1447:
311:
Human Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display Library, Nature Biotechnology, 1996
533:
352:
Directed selection of MIP-1 alpha neutralizing CCR5 antibodies from a phage display human antibody library, Nat Biotechnology, 1999
1149:
Osbourn, JK (1989). "Directed selection of MIP-1 alpha neutralizing CCR5 antibodies from a phage display human antibody library".
1982:
474:
444:
On 1 July that year, Osbourn gave evidence to the Science and Technology Select Committee: Priorities for Scientific Research.
393:
Osbourn also created a technique to assist with the discovery of proximity-guided selection of antibodies, so called Proximol.
302:. CAT, as it was called, would pioneer the use of Phage Display technology that ultimately discovered important drugs such as
447:
Osbourn has also has previously served as a Member of the UK Medical Research Council Industry Grant Award Assessment Panel.
1563:
1835:"SCIENCE AND TECHNOLOGY SELECT COMMITTEE : 2025: Priorities for Scientific Research : Oral and written evidence"
1387:
502:
299:
249:
191:
187:
107:
74:
1581:
210:
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1962:
1227:
Osbourn, JK (1996). "Generation of a panel of related human scFv antibodies with high affinities for human CEA".
627:
501:. This well-deserved honour reflects her contribution to biopharmaceutical science over more than 25 years, from
362:
Generation of a panel of related human scFv antibodies with high affinities for human CEA, Immunotechnology, 1996
327:
Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment, Sci Rep, 2018
1493:
404:, UK. Jonathan Burroughs, of Creative Places, wrote in 2015 that Osbourn had an influence over this decision.
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770:
554:
1972:
1712:
226:
70:
1939:"Dr Jane Osbourn of AstraZeneca and UK BioIndustry Association thanks colleagues as she is made an OBE"
735:"Dr Jane Osbourn of AstraZeneca and UK BioIndustry Affiliation thanks colleagues as she is made an OBE"
929:
655:
264:
91:
433:
Director of Cambridge Enterprise, the technology transfer organisation for University of Cambridge.
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494:
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medal for services to "Human Monoclonal Antibody Drug Research and Development and Biotechnology".
78:
918:"Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment"
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857:
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at Queens, and was awarded both a third year Foundation Scholarship and The Henry Mosseri prize.
1490:"AstraZeneca International - pharmaceutical company, prescription drugs, medicine manufacturers"
428:
biotech and medtech, from pre-clinical science through clinical testing and regulatory approval.
371:
EP0865492B1 - Specific binding members for human carcinoembryonic antigen, materials and methods
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229:. She is married to John Richer, Professor of Physics at the Cavendish Laboratory, Cambridge.
83:
1763:"BABRAHAM BIOSCIENCE TECHNOLOGIES LIMITED - Officers (free information from Companies House)"
832:
Vaughan, T. J.; Osbourn, J. K.; Tempest, P. R. (30 June 1998). "Human antibodies by design".
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466:. Winter received his award for the phage display of peptides and antibodies. Sir Greg and
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Osbourn is listed as an inventor on several patents, which are (in chronological order):
933:
337:
Applications of ribosome display to antibody drug discovery, Expert Opin Biol Ther, 2015
190:, Osbourn completed several post-graduate qualifications before moving into industry at
1781:"CAMBRIDGE ENTERPRISE LIMITED - Filing history (free information from Companies House)"
999:
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317:. She is co-author of several others pertaining to antibody discovery and development:
50:
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534:"MedImmune's Jane Osbourn announced as new BIA chair alongside new board appointments"
1956:
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In 1993 she moved to a small, Cambridge-based, start-up biotechnology company called
136:
1263:"Specific binding members for human carcinoembryonic antigen, materials and methods"
1178:
1135:
1051:
861:
818:
716:
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Osbourn, Jane K. (30 July 2002). "Proximity-guided (ProxiMol) antibody selection".
1362:
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1262:
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Osbourn, JK (1998). "Pathfinder selection: in situ isolation of novel antibodies".
357:
Pathfinder selection: in situ isolation of novel antibodies, Immunotechnology, 1998
237:
233:
1471:
1312:
1022:
Groves, MA (2015). "Applications of ribosome display to antibody drug discovery".
1921:"World leading antibody scientist Dr Jane Osbourn awarded OBE in Queen's Honours"
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149:
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753:"Jane joined what was Cambridge Antibody Technology (CAT)/MedImmune, in 1993"
342:
Signal amplification in flow cytometry using biotin tyramine, Cytometry, 1999
1637:
1084:
10.1002/(SICI)1097-0320(19990201)35:2<176::AID-CYTO10>3.0.CO;2-S
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In 2013, AstraZeneca announced its decision to relocate its headquarters to
195:
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in Natural Sciences (Biochemistry). She was recognised in 1986 for playing
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1434:. Methods in Molecular Biology. Vol. 178. pp. 201–205.
309:
She was the key author of several scientific papers, including
1067:"Signal amplification in flow cytometry using biotin tyramine"
513:
and education outreach, in particular for women in science".
279:. Following this, she completed a post-doctoral position at
315:
Human Antibodies by Design, Nature Biotechnology, 1998
1508:"How can we encourage more girls to study science?"
160:
142:
132:
98:
66:
58:
37:
23:
1564:"BIA chairwomen Jane Osbourn to leave AstraZeneca"
380:EP1353180B1 - Labelling and selection of molecules
417:pharmaceutical media groups for these qualities.
389:WO2001075097A2 - Improvements to Ribosome Display
377:US5994519A - Labelling and selection of molecules
179:, OBE, is a scientist and former chair of the UK
374:EP0906571 - Labelling and selection of molecules
482:, accompanied Sir Greg to the Nobel ceremony.
8:
1388:"About this file - European Patent Register"
386:EP1268766 - Improvements to Ribosome Display
1610:"50 Movers and Shakers in BioBusiness 2016"
1582:"50 Movers and Shakers in BioBusiness 2014"
1968:Members of the Order of the British Empire
20:
1082:
998:
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1546:"Creative Places | Open Innovation"
555:"The Queen's Birthday Honours List 2019"
771:"The Top 15 Best-Selling Drugs of 2016"
528:
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275:, which resulted in the publication of
236:who investigates plant natural product
1528:"Cambridge HQ for pharmaceutical firm"
1338:"Labelling and selection of molecules"
1313:"Labelling and selection of molecules"
1288:"Labelling and selection of molecules"
549:
547:
209:list of 2019, Osbourn was awarded the
454:for Chemistry was awarded jointly to
7:
1978:Alumni of Queens' College, Cambridge
1881:"The Nobel Prize in Chemistry 2018"
1663:"The Researchers & Scientists"
1472:"AstraZeneca to buy CAT for ÂŁ702m"
1406:"Improvements to ribosome display"
497:drug research and development and
14:
1492:. 13 January 2010. Archived from
1713:"Fierce Women in Biopharma 2016"
248:Osbourn went on to study at the
1901:Walsh, Louise (20 March 2019).
916:Chodorge, M (3 December 2018).
225:, West Yorkshire, and attended
186:A Natural Sciences graduate of
1943:www.cambridgeindependent.co.uk
757:www.cambridgeindependent.co.uk
586:Osbourn, Anne (30 July 2015).
271:for Plant Science Research in
1:
1988:21st-century women scientists
1241:10.1016/S1380-2933(96)00046-2
1206:10.1016/S1380-2933(97)10007-0
628:"Queens' College Record 1986"
503:Cambridge Antibody Technology
300:Cambridge Antibody Technology
192:Cambridge Antibody Technology
108:Cambridge Antibody Technology
695:10.1016/0042-6822(89)90143-8
383:US7074557 - Ribosome Display
894:10.1016/j.ccell.2019.05.010
211:Order of the British Empire
2004:
1817:"[Committee name]"
1785:Beta.companieshouse.gov.uk
1767:Beta.companieshouse.gov.uk
942:10.1038/s41598-018-35869-4
263:She went on to complete a
250:Queens' College, Cambridge
234:Professor Anne Osbourn FRS
188:Queens' College, Cambridge
75:Queens' College, Cambridge
1440:10.1385/1-59259-240-6:201
573:"Professor John S Richer"
170:
125:
1903:"A very Cambridge story"
1036:10.1517/14712598.5.1.125
1907:University of Cambridge
875:Li, JY (10 June 2019).
252:, where she obtained a
16:British biotechnologist
1983:Women biotechnologists
1432:Antibody Phage Display
227:Bingley Grammar School
71:Bingley Grammar School
42:Jane Katharine Osbourn
1065:Earnshaw, JC (1999).
1024:Expert Opin Biol Ther
232:She is the sister of
1867:Businessweekly.co.uk
1642:Mws-consulting.co.uk
1617:Mws-consulting.co.uk
1589:Mws-consulting.co.uk
973:Tani, H (May 2013).
834:Nature Biotechnology
791:Nature Biotechnology
221:Osbourn was born in
166:T. Michael A. Wilson
1799:"Parliamentlive.tv"
1568:Thepharmaletter.com
1496:on 13 January 2010.
1163:10.1038/nbt0898-778
934:2018NatSR...817545C
846:10.1038/nbt0698-535
803:10.1038/nbt0396-309
505:to AstraZeneca and
495:monoclonal antibody
1821:Data.parliament.uk
1550:Creativeplaces.com
1516:. 9 December 2014.
1410:Patents.google.com
1367:Patents.google.com
1363:"Ribosome display"
1342:Patents.google.com
1317:Patents.google.com
1292:Patents.google.com
1267:Patents.google.com
991:10.4161/mabs.24112
294:Career in industry
281:Rutgers University
1803:Parliamentlive.tv
1120:10.1159/000025674
656:"The Record 1988"
605:10.1111/nph.13616
269:John Innes Centre
174:
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127:Scientific career
84:John Innes Centre
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575:. 19 April 2013.
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254:1st class degree
207:Birthday Honours
162:Doctoral advisor
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1534:. 18 June 2013.
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777:. 6 March 2017.
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538:Bioindustry.org
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480:John McCafferty
456:Sir Greg Winter
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244:Academic career
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205:In the Queen's
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1945:. 7 June 2019.
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1885:NobelPrize.org
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1638:"Biobeat 2018"
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1478:. 15 May 2006.
1476:News.bbc.co.uk
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1200:(4): 293–302.
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1157:(8): 778–781.
1151:Nat Biotechnol
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1114:(5): 353–362.
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1030:(1): 125–135.
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985:(3): 471–478.
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887:(6): 948–949.
867:
840:(6): 535–539.
824:
797:(3): 309–314.
780:
775:Genengnews.com
762:
759:. 7 June 2019.
744:
741:. 7 June 2019.
726:
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689:(1): 370–373.
672:
647:
619:
588:"Anne Osbourn"
578:
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468:David Chiswell
464:Frances Arnold
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