169:(HES) to boost blood pressure during surgery. However, a meta-analysis of trials that excluded Boldt's fabricated data found that the intravenous use of hydroxyethyl starch is associated with a significant increased risk of death and acute kidney injury compared with other resuscitation solutions. He was stripped of his professorship and came under criminal investigation for possible forgery of up to 90 research studies.
25:
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In August 2012, the hospital released the results of the investigation: while it did not find that any patients were harmed, "in a large number of the studies investigated, the conduct of research failed to meet required standards. False data were published in at least 10 of the 91 articles examined,
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published a meta-analysis on HES in critically ill patients. Boldt had seven studies from the 1990s that had not yet been retracted. If Boldt's papers were included in the analysis no increase in mortality was apparent; but if they were excluded, mortality was seen to increase significantly with use
259:
By 2017, 96 of Boldt's papers had been retracted. In
October 2018, a review highlighted additional retractions, dating back to 1986, demonstrating persistent fraud since the start of Boldt's career. Statistical analyses found that it was likely that many fraudulent papers from Boldt remained, and
397:
Zarychanski, Ryan; Abou-Setta, Ahmed M.; Turgeon, Alexis F.; Houston, Brett L.; McIntyre, Lauralyn; Marshall, John C.; Fergusson, Dean A. (2013). "Association of
Hydroxyethyl Starch Administration with Mortality and Acute Kidney Injury in Critically Ill Patients Requiring Volume Resuscitation".
260:
recommended that editors should take action. However, some of Boldt's papers were not retracted until 2023. As of August 2023, 199 of Boldt's research publications had been retracted—a record for the author with the most retractions. This count has increased to 210 retractions as of May 2024.
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An overview of the challenges that this fraud presented for the meta-analysts was published in 2013. The fraud included double publication of studies, manipulating demographic and outcome data to conceal double publication, and showing better results for a drug being tested.
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of HES. The Boldt studies, but no others, showed an improvement with HES; all other studies showed significant risks with no benefits. It is considered that his fraudulent studies caused harm and risk to critically ill patients.
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with insufficient background research. His field of research and the publications were related to hydroxyethyl starch. Some 90 studies he published were being reviewed by medical authorities in 2011.
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297:(Report) (in German). Deutschen Gesellschaft für Chirurgie (DGCH) und der Deutschen Gesellschaft für Anästhesiologie und Intensivmedizin (DGAI). p. 17. Archived from
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532:(Press release). Akademisches Lehrkrankenhaus der Johannes Gutenberg-Universität Mainz. 18 October 2012. Archived from
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625:"The Boldt scandal still in need of action: The example of colloids 10 years after initial suspicion of fraud"
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including, for instance, data on patient numbers/study groups as well as data on the timing of measurements".
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Antonelli, Massimo; Sandroni, Claudio (2013). "Hydroxyethyl Starch for
Intravenous Volume Replacement".
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Informationsdienst
Wissenschaft: "DGAI: Wissenschaftliches Fehlverhalten in der Anästhesie inakzeptabel"
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526:"Hospital Presents Results of Final Report: Committee Completes Investigation in the Case of Dr Boldt"
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692:"The new retraction record holder is a German anesthesiologist [Joachim Boldt], with 184"
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who fabricated or falsified data, including those reporting clinical trial results.
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On 10 November 2010 Boldt was suspended from
Klinikum Ludwigshafen, a hospital in
230:. His case was described as "possibly the biggest medical research scandal since
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was struck off in 2010 for falsely claiming to have proved a link between the
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for failing to teach, and the university investigated possible charges of
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489:"Joachim Boldt profile: a glittering career built on charisma and charm"
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Boldt was previously considered to be a leading researcher of medicinal
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In
February 2011, Boldt was stripped of his title of professor at the
438:"Millions of surgery patients at risk in drug research fraud scandal"
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50 Items
Displayed Out of 199 Item(s) Found (search on 9 August 2023)
717:"A retraction milestone: 200 for one author - Retraction Watch"
674:"There's far more scientific fraud than anyone wants to admit"
18:
436:
Blake, Heidi; Watt, Holly; Winnett, Robert (3 March 2011).
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Giessen
University: "Akademische Bezeichnung aberkannt"
289:"Curriculum Vitae - Professor Dr. med. Joachim Boldt".
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Wiedermann, Christian J.; Joannidis, Michael (2018).
16:
German anesthesiologist known for research misconduct
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783:People involved in scientific misconduct incidents
584:"The Boldt affair: a quandary for meta-analysts"
582:Wilkes, Mahlon M.; Navickis, Roberta J. (2013).
459:"Medical journals retract 'unethical' research"
165:. He was an advocate for the use of colloidal
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477:2010-11-26 (retrieved 2011-03-04) German
49:of all important aspects of the article.
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270:List of scientific misconduct incidents
45:Please consider expanding the lead to
149:(born 29 September 1954) is a German
7:
512:2011-02-15 (retrieved: 2011-03-04)
325:. Center for Scientific Integrity.
191:European Journal of Anaesthesiology
610:"The Retraction Watch Leaderboard"
499:from the original on 7 March 2011.
448:from the original on 5 March 2011.
215:, for a scientific publication in
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778:Medical controversies in Germany
530:klilu.de (Klinikum Ludwigshafen)
23:
672:Oransky, Ivan (9 August 2023).
37:may be too short to adequately
758:21st-century German physicians
753:20th-century German physicians
291:Gemeinsame Presseveranstaltung
197:British Journal of Anaesthesia
47:provide an accessible overview
1:
487:Blake, Heidi (3 March 2011).
341:"Boldt: the great pretender"
319:"Search for "Joachim Boldt""
293:[Joint press event]
172:The editors of 16 different
157:Medical research fabrication
339:Wise, Jacqui (2013-03-19).
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217:Anesthesia & Analgesia
202:institutional review board
179:Anesthesia & Analgesia
105:Falsifying scientific data
641:10.1007/s00134-018-5289-3
323:Retraction Watch Database
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763:German anesthesiologists
594:(4): 8–9. Archived from
629:Intensive Care Medicine
236:MMR vaccine and autism
561:10.1001/jama.2013.851
412:10.1001/jama.2013.430
245:On 20 February 2013,
228:scientific misconduct
224:University of Giessen
135:University of Giessen
131:Ludwigshafen Hospital
768:Health fraud people
588:Anesthesiology News
536:on 22 October 2012.
493:The Daily Telegraph
442:The Daily Telegraph
174:scientific journals
167:hydroxyethyl starch
635:(10): 1735–1737.
357:10.1136/bmj.f1738
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111:Scientific career
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725:. Retrieved
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127:Institutions
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34:lead section
748:1954 births
514:(in German)
185:Anaesthesia
94:Nationality
742:Categories
727:2024-05-23
702:2023-08-03
276:References
204:approval.
194:, and the
82:1954-09-29
55:April 2024
365:1756-1833
351:: f1738.
39:summarize
659:29968012
569:23423420
497:Archived
446:Archived
420:23423413
381:38003087
373:23512099
264:See also
163:colloids
650:7572333
463:Reuters
213:Germany
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188:, the
117:Fields
97:German
377:S2CID
302:(PDF)
295:(PDF)
655:PMID
565:PMID
549:JAMA
416:PMID
400:JAMA
369:PMID
361:ISSN
248:JAMA
76:Born
645:PMC
637:doi
557:doi
553:309
408:doi
404:309
353:doi
349:346
345:BMJ
238:".
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