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described novel molecular mechanisms of approved psychotropic drugs, namely that memantine, amantadine, budipine and orphenadrine act as low-affinity NMDA-receptor antagonists. The data obtained with memantine formed an important basis for its worldwide approval as an antidementive drug. Kornhuber developed the pharmacokinetic hypothesis explaining the delayed therapeutic effects of antidepressant drugs. Furthermore, he found that antidepressant drugs like amitriptyline and fluoxetine mediate their effects on neurogenesis and behavior by lowering ceramide abundance in the brain. Among his coauthors has been
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His research interests include the pathophysiology of
Alzheimer’s disease, the early diagnosis and treatment of dementia syndromes, the pathophysiology of alcohol addiction and the pathophysiology of major depressive disorder. He has authored or co-authored more than 400 Journal articles. Kornhuber
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Slow accumulation of psychotropic substances in the human brain. Relationship to therapeutic latency of neuroleptic and antidepressant drugs?
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Award „ZukunftErfindenNRW“ Der
HochschulWettbewerb 2011 3. Preis (together with Wiltfang J, Maler M, et al.) (2011)
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Psychotogenicity and NMDA receptor antagonism: implications for neuroprotective pharmacotherapy
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Memantine displaces MK-801 at therapeutic concentrations in postmortem human frontal cortex
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Awards for Good
Teaching, University of Erlangen-Nuremberg (2006, 2010, 2013, 2014, 2015)
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Ehrenpreis – Deutscher Förderpreis für
Schmerzforschung und Schmerztherapie (2000)
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Rafaelsen Award of the
Collegium Internationale Neuro-Psychopharmacologicum (1994)
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Acid sphingomyelinase/ceramide system mediates effects of antidepressant drugs
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Organon-Award of the German
Society for Biological Psychiatry (1990)
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Scientific Award of the
Senator Dr. Franz Burda-Foundation (1995)
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Scientific Award of the German
Society for Psychiatry (1990)
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Kornhuber worked in the
Department of Psychiatry at the
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Academic staff of the University of Erlangen-Nuremberg
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Klaesi-Award, Swiss Academy of Medical Sciences (1995)
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The ceramide system as a novel antidepressant target
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Annika Liese-Award (together with Gulbins E) (2014)
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316:Trends in Pharmacological Sciences
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259:Kornhuber J, Retz W, Riederer P.
214:European Journal of Pharmacology
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309:Kornhuber J, Müller CP, et al.
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265:Journal of Neural Transmission
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283:Gulbins E, Palmada M, et al.
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364:German psychotherapists
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