313:
290:
187:
212:
4731:
4716:
564:
319:
218:
40:
4701:
2302:
Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, LeeHealey CJ, S Andrews B, Sankaranarayanan A, Homerick D, Roeck WW, Tehranzadeh J, Stanhope KL, Zimin P, Havel PJ, Griffey S, Knaus HG, Nepom GT, Gutman GA, Calabresi PA, Chandy
1127:
from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes –
1455:
1.3 channels have been found to be highly expressed by activated and plaque-associated microglia in human
Alzheimer's disease (AD) post-mortem brains as well as in mouse models of AD pathology. Patch-clamp recordings and flow cytometric studies performed on acutely isolated mouse microglia have
4174:
Koo GC, Blake JT, Shah K, Staruch MJ, Dumont F, Wunderler D, Sanchez M, McManus OB, Sirotina-Meisher A, Fischer P, Boltz RC, Goetz MA, Baker R, Bao J, Kayser F, Rupprecht KM, Parsons WH, Tong XC, Ita IE, Pivnichny J, Vincent S, Cunningham P, Hora D, Feeney W, Kaczorowski G (November 1999).
66:
3763:
Pennington MW, Mahnir VM, Krafte DS, Zaydenberg I, Byrnes ME, Khaytin I, Crowley K, Kem WR (February 1996). "Identification of three separate binding sites on SHK toxin, a potent inhibitor of voltage-dependent potassium channels in human T-lymphocytes and rat brain".
4254:
Nguyen A, Kath JC, Hanson DC, Biggers MS, Canniff PC, Donovan CB, Mather RJ, Bruns MJ, Rauer H, Aiyar J, Lepple-Wienhues A, Gutman GA, Grissmer S, Cahalan MD, Chandy KG (December 1996). "Novel nonpeptide agents potently block the C-type inactivated conformation of
1742:
Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of
Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels".
4214:
Miao S, Bao J, Garcia ML, Goulet JL, Hong XJ, Kaczorowski GJ, Kayser F, Koo GC, Kotliar A, Schmalhofer WA, Shah K, Sinclair PJ, Slaughter RS, Springer MS, Staruch MJ, Tsou NN, Wong F, Parsons WH, Rupprecht KM (March 2003). "Benzamide derivatives as blockers of
3979:
Pennington MW, Beeton C, Galea CA, Smith BJ, Chi V, Monaghan KP, Garcia A, Rangaraju S, Giuffrida A, Plank D, Crossley G, Nugent D, Khaytin I, Lefievre Y, Peshenko I, Dixon C, Chauhan S, Orzel A, Inoue T, Hu X, Moore RV, Norton RS, Chandy KG (April 2009).
4596:
Selby W, Pavli P, Crotty B, Florin T, Radford-Smith G, Gibson P, Mitchell B, Connell W, Read R, Merrett M, Ee H, Hetzel D (June 2007). "Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease".
3557:
Koo GC, Blake JT, Talento A, Nguyen M, Lin S, Sirotina A, Shah K, Mulvany K, Hora D, Cunningham P, Wunderler DL, McManus OB, Slaughter R, Bugianesi R, Felix J, Garcia M, Williamson J, Kaczorowski G, Sigal NH, Springer MS, Feeney W (June 1997).
3513:
Mouhat S, Teodorescu G, Homerick D, Visan V, Wulff H, Wu Y, Grissmer S, Darbon H, De Waard M, Sabatier JM (January 2006). "Pharmacological profiling of
Orthochirus scrobiculosus toxin 1 analogs with a trimmed N-terminal domain".
3715:
Bagdány M, Batista CV, Valdez-Cruz NA, Somodi S, Rodriguez de la Vega RC, Licea AF, Varga Z, Gáspár R, Possani LD, Panyi G (April 2005). "Anuroctoxin, a new scorpion toxin of the alpha-KTx 6 subfamily, is highly selective for
1468:
1.3 channels by the small molecule Pap1 as well as a peptide sea anemone toxin-based peptide ShK-223 have been found to limit amyloid beta plaque burden in mouse AD models, potentially via augmented clearance by microglia.
4439:
Bezerra EL, Vilar MJ, da
Trindade Neto PB, Sato EI (October 2005). "Double-blind, randomized, controlled clinical trial of clofazimine compared with chloroquine in patients with systemic lupus erythematosus".
2373:
Matheu MP, Beeton C, Garcia A, Chi V, Rangaraju S, Safrina O, Monaghan K, Uemura MI, Li D, Pal S, de la Maza LM, Monuki E, Flügel A, Pennington MW, Parker I, Chandy KG, Cahalan MD (October 2008).
1392:
1.3 blockers have prevented and treated disease in rat models of multiple sclerosis, type-1 diabetes mellitus, rheumatoid arthritis, contact dermatitis, and delayed-type hypersensitivity.
2732:
Rus H, Pardo CA, Hu L, Darrah E, Cudrici C, Niculescu T, Niculescu F, Mullen KM, Allie R, Guo L, Wulff H, Beeton C, Judge SI, Kerr DA, Knaus HG, Chandy KG, Calabresi PA (August 2005).
5555:
2027:
Cai YC, Osborne PB, North RA, Dooley DC, Douglass J (March 1992). "Characterization and functional expression of genomic DNA encoding the human lymphocyte type n potassium channel".
6465:
1937:
Chandy KG, Williams CB, Spencer RH, Aguilar BA, Ghanshani S, Tempel BL, Gutman GA (February 1990). "A family of three mouse potassium channel genes with intronless coding regions".
6200:
5452:
5385:
3848:
Kalman K, Pennington MW, Lanigan MD, Nguyen A, Rauer H, Mahnir V, Paschetto K, Kem WR, Grissmer S, Gutman GA, Christian EP, Cahalan MD, Norton RS, Chandy KG (December 1998).
326:
225:
1395:
At therapeutic concentrations, the blockers did not cause any clinically evident toxicity in rodents, and it did not compromise the protective immune response to acute
1352:(MS), disease-associated myelin-specific T cells from the blood are predominantly co-stimulation-independent effector-memory T cells that express high numbers of K
4730:
4715:
3611:
Abdel-Mottaleb, Yousra; Vandendriessche, Thomas; Clynen, Elke; Landuyt, Bart; Jalali, Amir; Vatanpour, Hossein; Schoofs, Liliane; Tytgat, Jan (2008-06-15).
1296:
1.3 blockers do not affect the homing to and motility within lymph nodes of naive and central memory T cells, most likely because these cells express the K
3195:
Valverde P, Kawai T, Taubman MA (June 2005). "Potassium channel-blockers as therapeutic agents to interfere with bone resorption of periodontal disease".
1545:
in humans. Furthermore, clofazimine in combination with the antibiotics clarithromycin and rifabutin induced remission for about 2 years in patients with
6995:
148:
832:
813:
4078:
Schmitz A, Sankaranarayanan A, Azam P, Schmidt-Lassen K, Homerick D, Hänsel W, Wulff H (November 2005). "Design of PAP-1, a selective small molecule K
4288:"A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K channels, Ca2+ signaling, and gene expression in T lymphocytes"
6396:
6379:
6374:
6369:
6364:
1356:
1.3 channels. T cells in MS lesions in postmortem brain lesions are also predominantly effector-memory T cells that express high levels of the K
6401:
5499:
4771:
3037:
1.3 gene-targeted deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice"
3458:
Rangaraju S, Raza SA, Pennati A, Deng Q, Dammer EB, Duong D, Pennington MW, Tansey MG, Lah JJ, Betarbet R, Seyfried NT, Levey AI (June 2017).
1292:
1.3 blockers paralyze effector-memory T cells at the sites of inflammation and prevent their reactivation in inflamed tissues. In contrast, K
4680:
1645:
1627:
7015:
6453:
5634:
1139:-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the
6351:
5372:
4788:
2800:"Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis"
1032:
312:
6137:
4700:
2857:
Beeton C, Pennington MW, Wulff H, Singh S, Nugent D, Crossley G, Khaytin I, Calabresi PA, Chen CY, Gutman GA, Chandy KG (April 2005).
1039:
3407:
Rangaraju S, Dammer EB, Raza SA, Rathakrishnan P, Xiao H, Gao T, Duong DM, Pennington MW, Lah JJ, Seyfried NT, Levey AI (May 2018).
289:
3895:"Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin"
4033:
Cotton J, Crest M, Bouet F, Alessandri N, Gola M, Forest E, Karlsson E, Castañeda O, Harvey AL, Vita C, Ménez A (February 1997).
1786:
DeCoursey TE, Chandy KG, Gupta S, Cahalan MD (1984). "Voltage-gated K channels in human T lymphocytes: a role in mitogenesis?".
1666:
1143:
class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in
3351:
Maezawa I, Nguyen HM, Di
Lucente J, Jenkins DP, Singh V, Hilt S, Kim K, Rangaraju S, Levey AI, Wulff H, Jin LW (February 2018).
6730:
5729:
5507:
4823:
3409:"Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease"
1614:
1593:
1566:
1233:
1.3 is physically coupled through a series of adaptor proteins to the T-cell receptor signaling complex and it traffics to the
1140:
6752:
1542:
1610:
4335:
Ren YR, Pan F, Parvez S, Fleig A, Chong CR, Xu J, Dang Y, Zhang J, Jiang H, Penner R, Liu JO (2008). Alberola-Ila J (ed.).
211:
186:
63:
6961:
4872:
4039:
1 channels. Revision of the amino acid sequence, disulfide-bridge assignment, chemical synthesis, and biological activity"
2798:
Beeton C, Wulff H, Barbaria J, Clot-Faybesse O, Pennington M, Bernard D, Cahalan MD, Chandy KG, Béraud E (November 2001).
2910:
Beeton C, Smith BJ, Sabo JK, Crossley G, Nugent D, Khaytin I, Chi V, Chandy KG, Pennington MW, Norton RS (January 2008).
1589:
1380:
3.1 channel upon activation. Consequently, it should be possible to selectively suppress effector-memory T cells with a K
6327:
5239:
4644:
1538:
1464:
1.3 channel gene has also been found to be a regulator of pro-inflammatory microglial responses. Selective blockade of K
1320:
1312:
128:
3666:
Aiyar J, Withka JM, Rizzi JP, Singleton DH, Andrews GC, Lin W, Boyd J, Hanson DC, Simon M, Dethlefs B (November 1995).
1376:. T cells with other antigen specificities in these patients were naive or central memory T cells that upregulate the K
6602:
3248:
Tschritter O, Machicao F, Stefan N, Schäfer S, Weigert C, Staiger H, Spieth C, Häring HU, Fritsche A (February 2006).
2912:"The D-diastereomer of ShK toxin selectively blocks voltage-gated K channels and inhibits T lymphocyte proliferation"
1837:
Matteson DR, Deutsch C (1984). "K channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesion".
3004:
Wulff H, Beeton C, Chandy KG (September 2003). "Potassium channels as therapeutic targets for autoimmune disorders".
325:
224:
2548:"Tyrosine phosphorylation-dependent suppression of a voltage-gated K channel in T lymphocytes upon Fas stimulation"
4780:
4764:
1440:
1316:
318:
217:
6956:
5166:
4673:
1534:
1124:
4561:
Arbiser JL, Moschella SL (February 1995). "Clofazimine: a review of its medical uses and mechanisms of action".
6946:
5207:
5083:
4652:
4638:
3357:
1.3 inhibition as a potential microglia-targeted therapy for
Alzheimer's disease: preclinical proof of concept"
1982:"Characterization and functional expression of a rat genomic DNA clone encoding a lymphocyte potassium channel"
1424:
877:
136:
1206:
3.1 channel to approximately 500 channels per cell, while effector-memory T cells increase expression of the K
2222:
Panyi G, Vámosi G, Bacsó Z, Bagdány M, Bodnár A, Varga Z, Gáspár R, Mátyus L, Damjanovich S (February 2004).
6951:
4286:
Ehring GR, Kerschbaum HH, Eder C, Neben AL, Fanger CM, Khoury RM, Negulescu PA, Cahalan MD (November 1998).
2228:
1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells"
858:
6982:
4974:
4961:
4948:
4928:
4915:
4880:
3204:
2634:"Glutathione depletion and disruption of intracellular ionic homeostasis regulate lymphoid cell apoptosis"
2183:"K channel expression during B cell differentiation: implications for immunomodulation and autoimmunity"
7020:
4757:
4518:
Chuaprapaisilp T, Piamphongsant T (September 1978). "Treatment of pustular psoriasis with clofazimine".
2375:"Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by K
1234:
3668:"Topology of the pore-region of a K channel revealed by the NMR-derived structures of scorpion toxins"
2546:
Szabò I, Gulbins E, Apfel H, Zhang X, Barth P, Busch AE, Schlottmann K, Pongs O, Lang F (August 1996).
4855:
4666:
4352:
3624:
3612:
3146:
2811:
2749:
2500:
2320:
2239:
1946:
1846:
1795:
1696:
1373:
1238:
1222:
3.1 expression after activation. In contrast, class-switched memory B cells express high numbers of K
200:
3559:
3209:
1981:
1368:-specific T cells isolated from the blood are effector-memory T cells that express high numbers of K
115:
4749:
3613:"OdK2, a Kv1.3 channel-selective toxin from the venom of the Iranian scorpion Odonthobuthus doriae"
1506:
1420:
1419:
1.3 is also considered a therapeutic target for the treatment of obesity, for enhancing peripheral
1400:
119:, HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3, potassium voltage-gated channel subfamily A member 3
4634:
2483:
Szabó I, Bock J, Grassmé H, Soddemann M, Wilker B, Lang F, Zoratti M, Gulbins E (September 2008).
6322:
5198:
4845:
4543:
4500:
4107:
3830:
3745:
3697:
3593:
3539:
3230:
2009:
1870:
1819:
1768:
1683:
Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, Chandy KG (December 1990).
1385:
1349:
1250:
160:
4475:
Mackey JP, Barnes J (July 1974). "Clofazimine in the treatment of discoid lupus erythematosus".
1546:
1522:
1015:
994:
968:
947:
5360:
4614:
4578:
4535:
4492:
4457:
4421:
4380:
4317:
4268:
4236:
4196:
4156:
4127:"Psora-4, a Kv1.3 Blocker, Enhances Differentiation and Maturation in Neural Progenitor Cells"
4099:
4060:
4015:
3961:
3916:
3875:
3822:
3781:
3737:
3689:
3648:
3640:
3585:
3531:
3495:
3440:
3386:
3328:
3275:
3222:
3174:
3111:
3066:
3013:
2986:
2933:
2892:
2839:
2777:
2714:
2665:
2614:
2569:
2528:
2462:
2408:
2348:
2267:
2204:
2160:
2100:
2044:
2001:
1962:
1919:
1862:
1811:
1760:
1724:
1550:
1361:
1254:
1120:
108:
56:
1518:
1481:
1.3 is blocked by several peptides from venomous creatures including scorpions (ADWX1, OSK1,
1372:
1.3 channels, and the same is true of T cells from the synovial joint fluid of patients with
6129:
5110:
4606:
4570:
4527:
4484:
4449:
4411:
4370:
4360:
4307:
4299:
4228:
4188:
4146:
4138:
4091:
4050:
4005:
3997:
3951:
3906:
3865:
3812:
3773:
3729:
3679:
3632:
3575:
3523:
3485:
3475:
3430:
3420:
3376:
3368:
3318:
3310:
3265:
3214:
3164:
3154:
3101:
3056:
3048:
2976:
2968:
2923:
2882:
2874:
2829:
2819:
2767:
2757:
2704:
2696:
2655:
2645:
2604:
2559:
2518:
2508:
2452:
2442:
2398:
2390:
2338:
2328:
2257:
2247:
2194:
2150:
2142:
2090:
2082:
2036:
1993:
1954:
1909:
1901:
1854:
1803:
1752:
1714:
1704:
1281:
405:
336:
280:
235:
2429:
Szabò I, Bock J, Jekle A, Soddemann M, Adams C, Lang F, Zoratti M, Gulbins E (April 2005).
1514:
1210:
1.3 channel. Among human B cells, naive and early memory B cells express small numbers of K
563:
156:
6665:
4805:
4035:"A potassium-channel toxin from the sea anemone Bunodosoma granulifera, an inhibitor for K
3129:
Xu J, Wang P, Li Y, Li G, Kaczmarek LK, Wu Y, Koni PA, Flavell RA, Desir GV (March 2004).
1554:
1428:
380:
3801:"Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone"
3084:
Xu J, Koni PA, Wang P, Li G, Kaczmarek L, Wu Y, Li Y, Flavell RA, Desir GV (March 2003).
4356:
3628:
3150:
2815:
2753:
2504:
2324:
2243:
1950:
1850:
1799:
1700:
1667:"Entrez Gene: KCNA3 potassium voltage-gated channel, shaker-related subfamily, member 3"
6461:
5148:
4531:
4488:
4375:
4336:
4312:
4287:
4151:
4126:
4010:
3981:
3490:
3459:
3435:
3408:
3381:
3352:
3323:
3294:
3061:
3032:
2981:
2952:
2887:
2858:
2772:
2733:
2660:
2633:
2523:
2484:
2403:
2374:
2343:
2304:
2095:
2070:
1914:
1889:
1510:
39:
4232:
3169:
3130:
2709:
2684:
2262:
2223:
2155:
2126:
2125:
Wulff H, Calabresi PA, Allie R, Yun S, Pennington M, Beeton C, Chandy KG (June 2003).
1533:
1.3 blocker clofazimine has been reported to be effective in the treatment of chronic
747:
742:
737:
732:
727:
722:
717:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
635:
630:
625:
620:
615:
610:
605:
7009:
6999:
6415:
6088:
4574:
4399:
4082:
1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases".
4055:
4034:
3684:
3667:
2834:
2799:
1772:
1719:
1684:
1490:
1432:
1285:
1199:
592:
4547:
4504:
4125:
Zhou YY, Hou GQ, He SW, Xiao Z, Xu HJ, Qiu YT, Jiang S, Zheng H, Li ZY (July 2015).
3749:
3701:
3597:
3234:
2013:
1874:
1226:
1.3 channels per cell (about 1500/cell) and this number increases after activation.
6768:
6159:
4111:
3834:
3543:
3254:
1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance"
2593:
1.3 potassium channels by death receptors during apoptosis in Jurkat T lymphocytes"
2587:
Storey NM, Gómez-Angelats M, Bortner CD, Armstrong DL, Cidlowski JA (August 2003).
1823:
1388:
without compromising the protective immune response. In proof-of-concept studies, K
1195:
398:
177:
4175:"Correolide and derivatives are novel immunosuppressants blocking the lymphocyte K
3636:
2683:
Markovic-Plese S, Cortese I, Wandinger KP, McFarland HF, Martin R (October 2001).
1980:
Douglass J, Osborne PB, Cai YC, Wilkinson M, Christie MJ, Adelman JP (June 1990).
140:
4610:
4365:
3580:
2394:
1997:
1890:"Voltage-gated potassium channels are required for human T lymphocyte activation"
164:
6698:
6693:
6688:
6683:
6570:
6409:
4784:
2738:
1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain"
1650:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1632:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1526:
1498:
1494:
1241:. However, blockade of the channel does not prevent immune synapse formation. K
1136:
3218:
3139:
Proceedings of the
National Academy of Sciences of the United States of America
2804:
Proceedings of the
National Academy of Sciences of the United States of America
2742:
Proceedings of the National Academy of Sciences of the United States of America
2493:
Proceedings of the National Academy of Sciences of the United States of America
2313:
Proceedings of the National Academy of Sciences of the United States of America
2232:
Proceedings of the National Academy of Sciences of the United States of America
2199:
2182:
2086:
1689:
Proceedings of the National Academy of Sciences of the United States of America
481:
6678:
6044:
5412:
5380:
3480:
3425:
2309:
1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases"
2069:
Chandy KG, Wulff H, Beeton C, Pennington M, Gutman GA, Cahalan MD (May 2004).
1486:
1482:
1129:
297:
194:
144:
4416:
3911:
3894:
3870:
3849:
3644:
2564:
2547:
6763:
6673:
3159:
2762:
2513:
2333:
2252:
2040:
1958:
1709:
1396:
777:
541:
419:
364:
351:
263:
250:
152:
4618:
4461:
4384:
4303:
4240:
4200:
4192:
4160:
4103:
4095:
4019:
4001:
3965:
3956:
3935:
3920:
3777:
3741:
3733:
3652:
3535:
3527:
3499:
3444:
3390:
3372:
3332:
3279:
3226:
3178:
3115:
3070:
3017:
2990:
2972:
2937:
2928:
2911:
2896:
2878:
2843:
2824:
2781:
2718:
2669:
2650:
2618:
2609:
2588:
2532:
2466:
2447:
2430:
2412:
2352:
2271:
2208:
2164:
2104:
1764:
1335:
1.3 modulation may be one of many mechanisms that contribute to apoptosis.
4739:: N-TERMINAL DOMAIN, VOLTAGE-GATED POTASSIUM CHANNEL KV1.2 RESIDUES 33-119
4724:: N-TERMINAL DOMAIN, VOLTAGE-GATED POTASSIUM CHANNEL KV1.2 RESIDUES 33-131
4582:
4496:
4425:
4321:
4272:
4064:
3879:
3826:
3785:
3693:
3589:
2859:"Targeting effector memory T cells with a selective peptide inhibitor of K
2632:
Franco R, DeHaven WI, Sifre MI, Bortner CD, Cidlowski JA (December 2008).
2573:
2048:
2005:
1966:
1923:
1905:
1888:
Chandy KG, DeCoursey TE, Cahalan MD, McLaughlin C, Gupta S (August 1984).
1866:
1815:
1728:
1079:
1074:
6776:
6124:
5103:
5098:
5093:
5088:
5020:
5015:
4539:
4341:
1.3 potassium channel by perturbing calcium oscillation in T lymphocytes"
3270:
3249:
3106:
3085:
2457:
1685:"Expression and chromosomal localization of a lymphocyte K channel gene"
1277:
1258:
1063:
922:
903:
3817:
3800:
3052:
2951:
Azam P, Sankaranarayanan A, Homerick D, Griffey S, Wulff H (June 2007).
6903:
6660:
6496:
4997:
4992:
4987:
3934:
Han S, Yi H, Yin SJ, Chen ZY, Liu H, Cao ZJ, Wu YL, Li WX (July 2008).
3314:
1756:
1107:
889:
844:
4453:
4142:
1276:
1.3 channels in effector-memory T cells suppresses calcium signaling,
85:
6580:
6575:
6309:
6304:
6250:
6245:
6061:
6049:
6039:
6034:
6022:
6017:
6012:
5899:
5894:
5889:
5781:
5717:
5712:
5707:
5702:
5697:
5692:
5687:
5622:
5617:
5607:
5602:
5597:
5548:
5543:
5533:
5528:
5405:
5400:
5395:
5390:
5296:
5291:
5286:
5276:
5271:
5261:
5256:
5186:
5181:
5176:
5171:
5074:
5069:
5064:
5059:
5047:
5042:
5037:
5032:
4941:
4908:
4903:
4898:
4893:
2700:
2146:
1858:
1807:
1328:
1179:
1175:
1156:
1148:
1144:
1047:
799:
17:
1549:, but the effect was temporary; the effect was thought to be due to
1135:
This gene encodes a member of the potassium channel, voltage-gated,
4398:
Lee SJ, Wegner SA, McGarigle CJ, Bierer BE, Antin JH (April 1997).
2685:"CD4+CD28- costimulation-independent T cells in multiple sclerosis"
1525:, benzamides, CP339818, progesterone and the anti-lepromatous drug
1439:
1.3 promoter region is associated with low insulin sensitivity and
1092:
Potassium voltage-gated channel, shaker-related subfamily, member 3
6814:
6745:
6740:
6735:
6652:
6639:
6634:
6629:
6624:
6619:
6614:
6565:
6558:
6553:
6548:
6543:
6538:
6533:
6528:
6523:
6511:
6506:
6501:
6491:
6486:
6481:
6476:
6391:
6335:
6292:
6287:
6282:
6277:
6272:
6267:
6262:
6240:
6235:
6230:
6225:
6220:
6215:
6210:
6191:
6186:
6181:
6176:
6164:
6081:
6076:
6071:
6056:
5994:
5989:
5984:
5975:
5970:
5956:
5951:
5942:
5937:
5932:
5923:
5918:
5909:
5904:
5871:
5866:
5861:
5856:
5847:
5838:
5833:
5828:
5819:
5814:
5809:
5804:
5795:
5790:
5776:
5771:
5766:
5761:
5751:
5746:
5682:
5677:
5672:
5667:
5662:
5657:
5652:
5647:
5612:
5582:
5577:
5572:
5567:
5538:
5487:
5482:
5477:
5472:
5462:
5457:
5437:
5422:
5417:
5332:
5327:
5322:
5317:
5301:
5281:
5266:
5227:
5222:
5217:
5212:
5120:
5115:
4838:
4833:
4828:
3299:
1.3 is highly expressed by microglia in human Alzheimer's disease"
1187:
1152:
4400:"Treatment of chronic graft-versus-host disease with clofazimine"
2131:
1.3 K(+) channel in effector memory T cells as new target for MS"
762:
758:
6894:
6889:
6884:
6874:
6869:
6864:
6854:
6849:
6844:
6839:
6834:
6829:
6824:
6809:
6804:
6799:
6794:
6789:
6784:
6723:
6718:
6713:
6708:
6703:
6609:
6597:
6592:
6587:
6518:
6471:
6435:
6430:
6425:
6420:
6147:
5965:
5523:
4860:
4850:
1502:
1460:
1.3 channels with disease progression in mouse AD models. The K
1365:
1114:
132:
6924:
6109:
5355:
5143:
4800:
4753:
4662:
572:
6448:
6346:
5467:
5427:
4658:
3936:"Structural basis of a potent peptide inhibitor designed for K
3799:
Tudor JE, Pallaghy PK, Pennington MW, Norton RS (April 1996).
1300:
3.1 channel and are, therefore, protected from the effect of K
3982:"Engineering a stable and selective peptide blocker of the K
2953:"Targeting effector memory T cells with the small molecule K
3464:
1.3 channel-dependent mechanisms in microglial activation"
3460:"A systems pharmacology-based approach to identify novel K
3893:
Rauer H, Pennington M, Cahalan M, Chandy KG (July 1999).
2957:
1.3 blocker PAP-1 suppresses allergic contact dermatitis"
1186:
1.3 channels per cell along with 10-20 calcium-activated
3940:
1.3 channel, a therapeutic target of autoimmune disease"
2181:
Wulff H, Knaus HG, Pennington M, Chandy KG (July 2004).
388:
1407:
1.3 blockers for the treatment of autoimmune diseases.
1128:
shaker, shaw, shab, and shal – have been identified in
3293:
Rangaraju S, Gearing M, Jin LW, Levey A (2015-02-06).
2431:"A novel potassium channel in lymphocyte mitochondria"
2071:"K channels as targets for specific immunomodulation"
1147:
proliferation and activation. This gene appears to be
3720:
1.3 over IKCa1 ion channels of human T lymphocytes".
553:
3258:
The Journal of Clinical Endocrinology and Metabolism
1132:, and each has been shown to have human homolog(s).
6937:
6761:
6650:
6446:
6344:
6320:
6122:
5728:
5633:
5498:
5371:
5238:
5197:
5159:
4871:
4816:
3766:
Biochemical and Biophysical Research Communications
3006:
Current Opinion in Drug Discovery & Development
1218:
3.1 channels when they are quiescent, and augment K
1008:
987:
961:
940:
524:
dentate gyrus of hippocampal formation granule cell
3560:"Blockade of the voltage-gated potassium channel K
2489:1.3 mediates Bax-induced apoptosis in lymphocytes"
1606:
1604:
1602:
1585:
1583:
1581:
3402:
3400:
3090:1.3 regulates energy homeostasis and body weight"
1403:bacterial infection. Many groups are developing K
1384:1.3-specific blocker and thereby ameliorate many
335:
234:
3190:
3188:
2863:1.3 channels for therapy of autoimmune diseases"
4709:: KV1.2 T1 DOMAIN, RESIDUES 33-119, T46V MUTANT
3346:
3344:
3342:
3031:Tucker K, Overton JM, Fadool DA (August 2008).
1678:
1676:
27:Protein-coding gene in the species Homo sapiens
4563:Journal of the American Academy of Dermatology
2793:
2791:
2368:
2366:
2364:
2362:
2297:
2295:
2293:
2291:
2289:
2287:
2285:
2283:
2281:
2064:
2062:
2060:
2058:
1611:GRCm38: Ensembl release 89: ENSMUSG00000047959
4765:
4674:
3135:1.3 regulates peripheral insulin sensitivity"
2478:
2476:
2424:
2422:
2176:
2174:
2120:
2118:
2116:
2114:
1311:1.3 has been reported to be expressed in the
1261:is promoted by potassium efflux through the K
8:
4221:Bioorganic & Medicinal Chemistry Letters
1509:, ShK-F6CA, ShK-186, ShK-192, BgK), and by
631:delayed rectifier potassium channel activity
606:outward rectifier potassium channel activity
3854:1.3-specific immunosuppressive polypeptide"
1590:GRCh38: Ensembl release 89: ENSG00000177272
748:potassium ion export across plasma membrane
697:integral component of postsynaptic membrane
6996:United States National Library of Medicine
6934:
6921:
6119:
6106:
5368:
5352:
5156:
5140:
4813:
4797:
4772:
4758:
4750:
4681:
4667:
4659:
1182:. All human T cells express roughly 300 K
773:
702:integral component of presynaptic membrane
588:
376:
275:
172:
74:
4651:at the U.S. National Library of Medicine
4637:at the U.S. National Library of Medicine
4415:
4374:
4364:
4311:
4150:
4054:
4009:
3955:
3910:
3869:
3816:
3683:
3579:
3489:
3479:
3434:
3424:
3380:
3322:
3269:
3208:
3168:
3158:
3105:
3060:
2980:
2927:
2886:
2833:
2823:
2771:
2761:
2708:
2659:
2649:
2608:
2563:
2522:
2512:
2456:
2446:
2402:
2342:
2332:
2261:
2251:
2198:
2154:
2094:
1913:
1718:
1708:
718:regulation of ion transmembrane transport
6994:This article incorporates text from the
2961:The Journal of Investigative Dermatology
1661:
1659:
626:voltage-gated potassium channel activity
4696:
1577:
657:voltage-gated potassium channel complex
3564:1.3 inhibits immune responses in vivo"
3131:"The voltage-gated potassium channel K
3086:"The voltage-gated potassium channel K
2734:"The voltage-gated potassium channel K
1553:activity, but could well have been an
1364:, the disease-associated insulin- and
1360:1.3 channel. In children with type-1
1319:has been suggested to insert into the
1315:in lymphocytes. The apoptotic protein
1257:of T cells. Calcium entry through the
29:
4259:1.3 and suppress T cell activation".
2689:The Journal of Clinical Investigation
2135:The Journal of Clinical Investigation
743:potassium ion transmembrane transport
667:integral component of plasma membrane
340:
301:
296:
239:
198:
193:
7:
4292:The Journal of Experimental Medicine
1894:The Journal of Experimental Medicine
1288:) and cell proliferation. In vivo, K
1123:represent the most complex class of
6138:Calcium-activated chloride channels
4131:CNS Neuroscience & Therapeutics
3944:The Journal of Biological Chemistry
3899:The Journal of Biological Chemistry
3858:The Journal of Biological Chemistry
2916:The Journal of Biological Chemistry
2638:The Journal of Biological Chemistry
2597:The Journal of Biological Chemistry
2552:The Journal of Biological Chemistry
2435:The Journal of Biological Chemistry
1174:1.3 channel, which is expressed in
5208:Amiloride-sensitive cation channel
4532:10.1111/j.1365-2133.1978.tb02001.x
4520:The British Journal of Dermatology
4489:10.1111/j.1365-2133.1974.tb06723.x
4477:The British Journal of Dermatology
2485:"Mitochondrial potassium channel K
2075:Trends in Pharmacological Sciences
1005:
984:
958:
937:
913:
894:
868:
849:
823:
804:
616:voltage-gated ion channel activity
558:
512:central gray substance of midbrain
476:
414:
393:
25:
1110:that in humans is encoded by the
4729:
4714:
4699:
4056:10.1111/j.1432-1033.1997.00192.x
4043:European Journal of Biochemistry
3041:International Journal of Obesity
562:
528:lumbar subsegment of spinal cord
324:
317:
311:
288:
223:
216:
210:
185:
38:
6731:Voltage-dependent anion channel
4824:Inositol trisphosphate receptor
1567:Voltage-gated potassium channel
1151:and is clustered together with
6753:General bacterial porin family
3303:Journal of Alzheimer's Disease
1435:. A genetic variation in the K
682:integral component of membrane
573:More reference expression data
542:More reference expression data
1:
4337:"Clofazimine inhibits human K
4233:10.1016/S0960-894X(03)00014-3
3986:1.3 channel in T lymphocytes"
3637:10.1016/j.toxicon.2008.03.027
3250:"A new variant in the human K
309:
208:
4611:10.1053/j.gastro.2007.03.031
4575:10.1016/0190-9622(95)90134-5
4366:10.1371/journal.pone.0004009
3685:10.1016/0896-6273(95)90104-3
3581:10.4049/jimmunol.158.11.5120
3468:Journal of Neuroinflammation
2395:10.1016/j.immuni.2008.07.015
1998:10.4049/jimmunol.144.12.4841
1321:outer mitochondrial membrane
1313:inner mitochondrial membrane
1202:increase expression of the K
7016:Genes on human chromosome 1
3413:Molecular Neurodegeneration
1456:confirmed upregulation of K
1170:encodes the voltage-gated K
738:protein homooligomerization
7037:
6172:Chloride Channel Accessory
4781:Membrane transport protein
3219:10.1177/154405910508400603
3197:Journal of Dental Research
2200:10.4049/jimmunol.173.2.776
2087:10.1016/j.tips.2004.03.010
1441:impaired glucose tolerance
1399:viral infection and acute
1125:voltage-gated ion channels
611:potassium channel activity
6978:
6933:
6920:
6118:
6105:
5367:
5351:
5167:Epithelial sodium channel
5155:
5139:
4812:
4796:
4694:
4179:1.3 potassium channels".
3805:Nature Structural Biology
3481:10.1186/s12974-017-0906-6
3426:10.1186/s13024-018-0254-8
1646:"Mouse PubMed Reference:"
1628:"Human PubMed Reference:"
1535:graft-versus-host disease
1323:and occlude the pore of K
1078:
1073:
1069:
1062:
1046:
1040:Chr 3: 106.94 – 106.95 Mb
1033:Chr 1: 110.67 – 110.67 Mb
1027:
1012:
991:
980:
965:
944:
933:
920:
916:
901:
897:
888:
875:
871:
856:
852:
843:
830:
826:
811:
807:
798:
783:
776:
772:
756:
591:
587:
570:
561:
552:
539:
488:
479:
426:
417:
387:
379:
375:
358:
345:
308:
287:
278:
274:
257:
244:
207:
184:
175:
171:
126:
123:
113:
106:
101:
82:
77:
60:
55:
50:
46:
37:
32:
5084:Cation channels of sperm
4653:Medical Subject Headings
4639:Medical Subject Headings
4442:Arthritis and Rheumatism
4417:10.1182/blood.V89.7.2298
3912:10.1074/jbc.274.31.21885
3871:10.1074/jbc.273.49.32697
3094:Human Molecular Genetics
2565:10.1074/jbc.271.34.20465
1425:type-2 diabetes mellitus
1269:3.1 potassium channels.
3160:10.1073/pnas.0308450100
2763:10.1073/pnas.0501770102
2514:10.1073/pnas.0804236105
2334:10.1073/pnas.0605136103
2253:10.1073/pnas.0307421100
2041:10.1089/dna.1992.11.163
1959:10.1126/science.2305265
1745:Pharmacological Reviews
1710:10.1073/pnas.87.23.9411
1557:effect by clofazimine.
1159:genes on chromosome 1.
733:transmembrane transport
728:potassium ion transport
4304:10.1084/jem.188.9.1593
4261:Molecular Pharmacology
4193:10.1006/cimm.1999.1569
4096:10.1124/mol.105.015669
4084:Molecular Pharmacology
4002:10.1124/mol.108.052704
3990:Molecular Pharmacology
3957:10.1074/jbc.M802054200
3850:"ShK-Dap22, a potent K
3778:10.1006/bbrc.1996.0297
3734:10.1124/mol.104.007187
3722:Molecular Pharmacology
3528:10.1124/mol.105.017210
3516:Molecular Pharmacology
2973:10.1038/sj.jid.5700717
2929:10.1074/jbc.M706008200
2879:10.1124/mol.104.008193
2867:Molecular Pharmacology
2825:10.1073/pnas.241497298
2651:10.1074/jbc.M807061200
2610:10.1074/jbc.M300443200
2448:10.1074/jbc.M413548200
516:superior frontal gyrus
342:3 F2.3|3 46.59 cM
5160:Constitutively active
4649:1.1+Potassium+Channel
3568:Journal of Immunology
2187:Journal of Immunology
1986:Journal of Immunology
1906:10.1084/jem.160.2.369
1427:, and for preventing
1339:Clinical significance
1235:immunological synapse
692:glutamatergic synapse
520:primary visual cortex
4635:KCNA1+protein,+human
3373:10.1093/brain/awx346
3295:"Potassium channel K
3271:10.1210/jc.2005-0725
2303:KG (November 2006).
2127:"The voltage-gated K
2029:DNA and Cell Biology
1374:rheumatoid arthritis
1239:antigen presentation
621:ion channel activity
303:Chromosome 3 (mouse)
201:Chromosome 1 (human)
78:List of PDB id codes
51:Available structures
6927:By gating mechanism
4357:2008PLoSO...3.4009R
4181:Cellular Immunology
3818:10.1038/nsb0496-317
3629:2008Txcn...51.1424A
3151:2004PNAS..101.3112X
3053:10.1038/ijo.2008.77
2816:2001PNAS...9813942B
2754:2005PNAS..10211094R
2505:2008PNAS..10514861S
2325:2006PNAS..10317414B
2244:2004PNAS..101.1285P
1951:1990Sci...247..973C
1851:1984Natur.307..468M
1800:1984Natur.307..465D
1701:1990PNAS...87.9411G
1505:) and sea anemone (
1433:periodontal disease
1421:insulin sensitivity
1386:autoimmune diseases
1194:. Upon activation,
500:ganglionic eminence
466:epithelium of colon
462:ganglionic eminence
6998:, which is in the
6454:TRP cation channel
6352:CNG cation channel
5635:Tandem pore domain
4846:Ryanodine receptor
4219:1.3 ion channel".
3315:10.3233/jad-141704
3107:10.1093/hmg/ddg049
2379:1.3 channel block"
1757:10.1124/pr.57.4.10
1551:anti-mycobacterial
1543:pustular psoriasis
1350:multiple sclerosis
1251:membrane potential
1121:Potassium channels
878:ENSMUSG00000047959
711:Biological process
645:Cellular component
599:Molecular function
6990:
6989:
6974:
6973:
6970:
6969:
6962:Stretch-activated
6939:Ion channel class
6916:
6915:
6912:
6911:
6101:
6100:
6097:
6096:
5373:Calcium-activated
5361:Potassium channel
5347:
5346:
5343:
5342:
5135:
5134:
5131:
5130:
4747:
4746:
4569:(2 Pt 1): 241–7.
4454:10.1002/art.21358
4143:10.1111/cns.12402
3864:(49): 32697–707.
2589:"Stimulation of K
1513:compounds (e.g.,
1447:Neurodegeneration
1423:in patients with
1362:diabetes mellitus
1348:In patients with
1255:calcium signaling
1141:delayed rectifier
1089:
1088:
1085:
1084:
1058:
1057:
1023:
1022:
1002:
1001:
976:
975:
955:
954:
929:
928:
910:
909:
884:
883:
865:
864:
839:
838:
820:
819:
768:
767:
583:
582:
579:
578:
548:
547:
535:
534:
473:
472:
434:bone marrow cells
371:
370:
270:
269:
165:KCNA3 - orthologs
97:
96:
93:
92:
61:Ortholog search:
16:(Redirected from
7028:
6935:
6922:
6130:Chloride channel
6120:
6107:
5500:Inward-rectifier
5369:
5353:
5157:
5141:
5111:Two-pore channel
4814:
4798:
4774:
4767:
4760:
4751:
4733:
4718:
4703:
4683:
4676:
4669:
4660:
4623:
4622:
4599:Gastroenterology
4593:
4587:
4586:
4558:
4552:
4551:
4515:
4509:
4508:
4472:
4466:
4465:
4436:
4430:
4429:
4419:
4395:
4389:
4388:
4378:
4368:
4332:
4326:
4325:
4315:
4283:
4277:
4276:
4251:
4245:
4244:
4211:
4205:
4204:
4171:
4165:
4164:
4154:
4122:
4116:
4115:
4075:
4069:
4068:
4058:
4030:
4024:
4023:
4013:
3976:
3970:
3969:
3959:
3950:(27): 19058–65.
3931:
3925:
3924:
3914:
3905:(31): 21885–92.
3890:
3884:
3883:
3873:
3845:
3839:
3838:
3820:
3796:
3790:
3789:
3760:
3754:
3753:
3712:
3706:
3705:
3687:
3663:
3657:
3656:
3623:(8): 1424–1430.
3608:
3602:
3601:
3583:
3554:
3548:
3547:
3510:
3504:
3503:
3493:
3483:
3455:
3449:
3448:
3438:
3428:
3404:
3395:
3394:
3384:
3348:
3337:
3336:
3326:
3290:
3284:
3283:
3273:
3245:
3239:
3238:
3212:
3192:
3183:
3182:
3172:
3162:
3126:
3120:
3119:
3109:
3081:
3075:
3074:
3064:
3028:
3022:
3021:
3001:
2995:
2994:
2984:
2948:
2942:
2941:
2931:
2907:
2901:
2900:
2890:
2854:
2848:
2847:
2837:
2827:
2795:
2786:
2785:
2775:
2765:
2729:
2723:
2722:
2712:
2701:10.1172/JCI12516
2680:
2674:
2673:
2663:
2653:
2644:(52): 36071–87.
2629:
2623:
2622:
2612:
2603:(35): 33319–26.
2584:
2578:
2577:
2567:
2543:
2537:
2536:
2526:
2516:
2480:
2471:
2470:
2460:
2450:
2426:
2417:
2416:
2406:
2370:
2357:
2356:
2346:
2336:
2299:
2276:
2275:
2265:
2255:
2219:
2213:
2212:
2202:
2178:
2169:
2168:
2158:
2147:10.1172/JCI16921
2122:
2109:
2108:
2098:
2066:
2053:
2052:
2024:
2018:
2017:
1977:
1971:
1970:
1934:
1928:
1927:
1917:
1885:
1879:
1878:
1859:10.1038/307468a0
1845:(5950): 468–71.
1834:
1828:
1827:
1808:10.1038/307465a0
1783:
1777:
1776:
1739:
1733:
1732:
1722:
1712:
1680:
1671:
1670:
1663:
1654:
1653:
1642:
1636:
1635:
1624:
1618:
1608:
1597:
1587:
1555:immunomodulatory
1331:residue. Thus, K
1282:interferon-gamma
1094:, also known as
1071:
1070:
1042:
1035:
1018:
1006:
997:
985:
981:RefSeq (protein)
971:
959:
950:
938:
914:
895:
869:
850:
824:
805:
774:
589:
575:
566:
559:
544:
496:ventricular zone
484:
482:Top expressed in
477:
438:ventricular zone
422:
420:Top expressed in
415:
394:
377:
367:
354:
343:
328:
321:
315:
304:
292:
276:
266:
253:
242:
227:
220:
214:
203:
189:
173:
167:
118:
111:
88:
75:
69:
48:
47:
42:
30:
21:
7036:
7035:
7031:
7030:
7029:
7027:
7026:
7025:
7006:
7005:
6991:
6986:
6966:
6929:
6908:
6757:
6656:
6646:
6442:
6340:
6316:
6114:
6093:
6007:
5884:
5741:
5724:
5629:
5593:
5563:
5519:
5511:
5494:
5448:
5363:
5339:
5312:
5251:
5234:
5193:
5151:
5127:
5010:
4982:
4969:
4956:
4936:
4923:
4888:
4867:
4808:
4806:Calcium channel
4792:
4778:
4748:
4743:
4740:
4734:
4725:
4719:
4710:
4704:
4690:
4687:
4648:
4631:
4626:
4595:
4594:
4590:
4560:
4559:
4555:
4517:
4516:
4512:
4474:
4473:
4469:
4438:
4437:
4433:
4410:(7): 2298–302.
4397:
4396:
4392:
4340:
4334:
4333:
4329:
4298:(9): 1593–602.
4285:
4284:
4280:
4258:
4253:
4252:
4248:
4218:
4213:
4212:
4208:
4178:
4173:
4172:
4168:
4124:
4123:
4119:
4081:
4077:
4076:
4072:
4038:
4032:
4031:
4027:
3985:
3978:
3977:
3973:
3939:
3933:
3932:
3928:
3892:
3891:
3887:
3853:
3847:
3846:
3842:
3798:
3797:
3793:
3762:
3761:
3757:
3719:
3714:
3713:
3709:
3665:
3664:
3660:
3610:
3609:
3605:
3563:
3556:
3555:
3551:
3512:
3511:
3507:
3463:
3457:
3456:
3452:
3406:
3405:
3398:
3356:
3350:
3349:
3340:
3298:
3292:
3291:
3287:
3253:
3247:
3246:
3242:
3210:10.1.1.327.7276
3194:
3193:
3186:
3134:
3128:
3127:
3123:
3089:
3083:
3082:
3078:
3036:
3030:
3029:
3025:
3003:
3002:
2998:
2956:
2950:
2949:
2945:
2909:
2908:
2904:
2862:
2856:
2855:
2851:
2810:(24): 13942–7.
2797:
2796:
2789:
2748:(31): 11094–9.
2737:
2731:
2730:
2726:
2682:
2681:
2677:
2631:
2630:
2626:
2592:
2586:
2585:
2581:
2558:(34): 20465–9.
2545:
2544:
2540:
2499:(39): 14861–6.
2488:
2482:
2481:
2474:
2441:(13): 12790–8.
2428:
2427:
2420:
2378:
2372:
2371:
2360:
2319:(46): 17414–9.
2308:
2301:
2300:
2279:
2227:
2221:
2220:
2216:
2180:
2179:
2172:
2141:(11): 1703–13.
2130:
2124:
2123:
2112:
2068:
2067:
2056:
2026:
2025:
2021:
1992:(12): 4841–50.
1979:
1978:
1974:
1945:(4945): 973–5.
1936:
1935:
1931:
1887:
1886:
1882:
1836:
1835:
1831:
1794:(5950): 465–8.
1785:
1784:
1780:
1741:
1740:
1736:
1682:
1681:
1674:
1665:
1664:
1657:
1644:
1643:
1639:
1626:
1625:
1621:
1609:
1600:
1588:
1579:
1575:
1563:
1547:Crohn's disease
1539:cutaneous lupus
1532:
1480:
1475:
1467:
1463:
1459:
1454:
1449:
1438:
1429:bone resorption
1418:
1413:
1406:
1391:
1383:
1379:
1371:
1359:
1355:
1346:
1341:
1334:
1326:
1310:
1303:
1299:
1295:
1291:
1275:
1268:
1264:
1248:
1244:
1232:
1225:
1221:
1217:
1213:
1209:
1205:
1191:
1185:
1173:
1165:
1103:
1080:View/Edit Mouse
1075:View/Edit Human
1038:
1031:
1028:Location (UCSC)
1014:
993:
967:
946:
859:ENSG00000177272
752:
706:
662:plasma membrane
640:
636:protein binding
571:
540:
531:
526:
522:
518:
514:
510:
506:
502:
498:
494:
480:
469:
464:
460:
456:
452:
448:
444:
440:
436:
432:
418:
362:
349:
341:
331:
330:
329:
322:
302:
279:Gene location (
261:
248:
240:
230:
229:
228:
221:
199:
176:Gene location (
127:
114:
107:
84:
62:
28:
23:
22:
15:
12:
11:
5:
7034:
7032:
7024:
7023:
7018:
7008:
7007:
6988:
6987:
6979:
6976:
6975:
6972:
6971:
6968:
6967:
6965:
6964:
6959:
6954:
6949:
6943:
6941:
6931:
6930:
6925:
6918:
6917:
6914:
6913:
6910:
6909:
6907:
6906:
6901:
6900:
6899:
6898:
6897:
6892:
6887:
6879:
6878:
6877:
6872:
6867:
6859:
6858:
6857:
6852:
6847:
6842:
6837:
6832:
6827:
6819:
6818:
6817:
6812:
6807:
6802:
6797:
6792:
6787:
6773:
6771:
6759:
6758:
6756:
6755:
6750:
6749:
6748:
6743:
6738:
6728:
6727:
6726:
6721:
6716:
6711:
6706:
6701:
6696:
6691:
6686:
6681:
6670:
6668:
6654:
6648:
6647:
6645:
6644:
6643:
6642:
6637:
6632:
6627:
6622:
6617:
6607:
6606:
6605:
6600:
6590:
6585:
6584:
6583:
6578:
6573:
6563:
6562:
6561:
6556:
6551:
6546:
6541:
6536:
6531:
6526:
6516:
6515:
6514:
6509:
6504:
6499:
6494:
6489:
6484:
6479:
6469:
6458:
6456:
6444:
6443:
6441:
6440:
6439:
6438:
6433:
6428:
6423:
6418:
6406:
6405:
6404:
6399:
6394:
6384:
6383:
6382:
6377:
6372:
6367:
6356:
6354:
6342:
6341:
6339:
6338:
6332:
6330:
6328:Proton channel
6318:
6317:
6315:
6314:
6313:
6312:
6307:
6297:
6296:
6295:
6290:
6285:
6280:
6275:
6270:
6265:
6255:
6254:
6253:
6248:
6243:
6238:
6233:
6228:
6223:
6218:
6213:
6203:
6198:
6197:
6196:
6195:
6194:
6189:
6184:
6179:
6169:
6168:
6167:
6162:
6152:
6151:
6150:
6134:
6132:
6116:
6115:
6110:
6103:
6102:
6099:
6098:
6095:
6094:
6092:
6091:
6086:
6085:
6084:
6079:
6074:
6064:
6059:
6054:
6053:
6052:
6047:
6042:
6037:
6027:
6026:
6025:
6020:
6015:
6005:
6000:
5999:
5998:
5997:
5992:
5987:
5980:
5979:
5978:
5973:
5968:
5961:
5960:
5959:
5954:
5947:
5946:
5945:
5940:
5935:
5928:
5927:
5926:
5921:
5914:
5913:
5912:
5907:
5902:
5897:
5892:
5882:
5877:
5876:
5875:
5874:
5869:
5864:
5859:
5852:
5851:
5850:
5843:
5842:
5841:
5836:
5831:
5824:
5823:
5822:
5817:
5812:
5807:
5800:
5799:
5798:
5793:
5786:
5785:
5784:
5779:
5774:
5769:
5764:
5759:
5754:
5749:
5739:
5734:
5732:
5726:
5725:
5723:
5722:
5721:
5720:
5715:
5710:
5705:
5700:
5695:
5690:
5685:
5680:
5675:
5670:
5665:
5660:
5655:
5650:
5639:
5637:
5631:
5630:
5628:
5627:
5626:
5625:
5620:
5615:
5610:
5605:
5600:
5591:
5587:
5586:
5585:
5580:
5575:
5570:
5561:
5553:
5552:
5551:
5546:
5541:
5536:
5531:
5526:
5517:
5513:
5509:
5504:
5502:
5496:
5495:
5493:
5492:
5491:
5490:
5485:
5480:
5475:
5470:
5465:
5460:
5455:
5446:
5442:
5441:
5440:
5432:
5431:
5430:
5425:
5420:
5410:
5409:
5408:
5403:
5398:
5393:
5388:
5377:
5375:
5365:
5364:
5356:
5349:
5348:
5345:
5344:
5341:
5340:
5338:
5337:
5336:
5335:
5330:
5325:
5320:
5310:
5306:
5305:
5304:
5299:
5294:
5289:
5284:
5279:
5274:
5269:
5264:
5259:
5249:
5244:
5242:
5236:
5235:
5233:
5232:
5231:
5230:
5225:
5220:
5215:
5204:
5202:
5195:
5194:
5192:
5191:
5190:
5189:
5184:
5179:
5174:
5163:
5161:
5153:
5152:
5149:Sodium channel
5144:
5137:
5136:
5133:
5132:
5129:
5128:
5126:
5125:
5124:
5123:
5118:
5108:
5107:
5106:
5101:
5096:
5091:
5080:
5079:
5078:
5077:
5072:
5067:
5062:
5052:
5051:
5050:
5045:
5040:
5035:
5025:
5024:
5023:
5018:
5008:
5003:
5002:
5001:
5000:
4995:
4990:
4980:
4972:
4967:
4959:
4954:
4946:
4945:
4944:
4934:
4926:
4921:
4913:
4912:
4911:
4906:
4901:
4896:
4886:
4877:
4875:
4869:
4868:
4866:
4865:
4864:
4863:
4858:
4853:
4843:
4842:
4841:
4836:
4831:
4820:
4818:
4810:
4809:
4801:
4794:
4793:
4779:
4777:
4776:
4769:
4762:
4754:
4745:
4744:
4742:
4741:
4735:
4728:
4726:
4720:
4713:
4711:
4705:
4698:
4695:
4692:
4691:
4688:
4686:
4685:
4678:
4671:
4663:
4657:
4656:
4646:
4642:
4630:
4629:External links
4627:
4625:
4624:
4588:
4553:
4510:
4467:
4448:(10): 3073–8.
4431:
4390:
4338:
4327:
4278:
4256:
4246:
4216:
4206:
4176:
4166:
4117:
4090:(5): 1254–70.
4079:
4070:
4049:(1): 192–202.
4036:
4025:
3983:
3971:
3937:
3926:
3885:
3851:
3840:
3791:
3772:(3): 696–701.
3755:
3728:(4): 1034–44.
3717:
3707:
3678:(5): 1169–81.
3658:
3603:
3574:(11): 5120–8.
3561:
3549:
3505:
3461:
3450:
3396:
3367:(2): 596–612.
3354:
3338:
3309:(3): 797–808.
3296:
3285:
3251:
3240:
3184:
3132:
3121:
3087:
3076:
3047:(8): 1222–32.
3034:
3023:
2996:
2967:(6): 1419–29.
2954:
2943:
2902:
2873:(4): 1369–81.
2860:
2849:
2787:
2735:
2724:
2695:(8): 1185–94.
2675:
2624:
2590:
2579:
2538:
2486:
2472:
2418:
2376:
2358:
2306:
2277:
2238:(5): 1285–90.
2225:
2214:
2170:
2128:
2110:
2054:
2019:
1972:
1929:
1880:
1829:
1778:
1751:(4): 473–508.
1734:
1695:(23): 9411–5.
1672:
1655:
1637:
1619:
1598:
1576:
1574:
1571:
1570:
1569:
1562:
1559:
1530:
1511:small molecule
1478:
1474:
1471:
1465:
1461:
1457:
1452:
1448:
1445:
1436:
1416:
1412:
1409:
1404:
1389:
1381:
1377:
1369:
1357:
1353:
1345:
1342:
1340:
1337:
1332:
1324:
1308:
1304:1.3 blockade.
1301:
1297:
1293:
1289:
1273:
1266:
1262:
1246:
1242:
1230:
1223:
1219:
1215:
1211:
1207:
1203:
1200:memory T cells
1189:
1183:
1171:
1164:
1161:
1101:
1087:
1086:
1083:
1082:
1077:
1067:
1066:
1060:
1059:
1056:
1055:
1053:
1051:
1044:
1043:
1036:
1029:
1025:
1024:
1021:
1020:
1010:
1009:
1003:
1000:
999:
989:
988:
982:
978:
977:
974:
973:
963:
962:
956:
953:
952:
942:
941:
935:
931:
930:
927:
926:
918:
917:
911:
908:
907:
899:
898:
892:
886:
885:
882:
881:
873:
872:
866:
863:
862:
854:
853:
847:
841:
840:
837:
836:
828:
827:
821:
818:
817:
809:
808:
802:
796:
795:
790:
785:
781:
780:
770:
769:
766:
765:
754:
753:
751:
750:
745:
740:
735:
730:
725:
720:
714:
712:
708:
707:
705:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
648:
646:
642:
641:
639:
638:
633:
628:
623:
618:
613:
608:
602:
600:
596:
595:
585:
584:
581:
580:
577:
576:
568:
567:
556:
550:
549:
546:
545:
537:
536:
533:
532:
530:
529:
525:
521:
517:
513:
509:
505:
501:
497:
493:
489:
486:
485:
474:
471:
470:
468:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
427:
424:
423:
411:
410:
402:
391:
385:
384:
381:RNA expression
373:
372:
369:
368:
360:
356:
355:
347:
344:
339:
333:
332:
323:
316:
310:
306:
305:
300:
294:
293:
285:
284:
272:
271:
268:
267:
259:
255:
254:
246:
243:
238:
232:
231:
222:
215:
209:
205:
204:
197:
191:
190:
182:
181:
169:
168:
125:
121:
120:
112:
104:
103:
99:
98:
95:
94:
91:
90:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
7033:
7022:
7019:
7017:
7014:
7013:
7011:
7004:
7003:
7001:
7000:public domain
6997:
6985:
6984:
6977:
6963:
6960:
6958:
6957:Voltage-gated
6955:
6953:
6950:
6948:
6945:
6944:
6942:
6940:
6936:
6932:
6928:
6923:
6919:
6905:
6902:
6896:
6893:
6891:
6888:
6886:
6883:
6882:
6880:
6876:
6873:
6871:
6868:
6866:
6863:
6862:
6860:
6856:
6853:
6851:
6848:
6846:
6843:
6841:
6838:
6836:
6833:
6831:
6828:
6826:
6823:
6822:
6820:
6816:
6813:
6811:
6808:
6806:
6803:
6801:
6798:
6796:
6793:
6791:
6788:
6786:
6783:
6782:
6780:
6779:
6778:
6775:
6774:
6772:
6770:
6767:
6765:
6760:
6754:
6751:
6747:
6744:
6742:
6739:
6737:
6734:
6733:
6732:
6729:
6725:
6722:
6720:
6717:
6715:
6712:
6710:
6707:
6705:
6702:
6700:
6697:
6695:
6692:
6690:
6687:
6685:
6682:
6680:
6677:
6676:
6675:
6672:
6671:
6669:
6667:
6664:
6662:
6658:
6649:
6641:
6638:
6636:
6633:
6631:
6628:
6626:
6623:
6621:
6618:
6616:
6613:
6612:
6611:
6608:
6604:
6601:
6599:
6596:
6595:
6594:
6591:
6589:
6586:
6582:
6579:
6577:
6574:
6572:
6569:
6568:
6567:
6564:
6560:
6557:
6555:
6552:
6550:
6547:
6545:
6542:
6540:
6537:
6535:
6532:
6530:
6527:
6525:
6522:
6521:
6520:
6517:
6513:
6510:
6508:
6505:
6503:
6500:
6498:
6495:
6493:
6490:
6488:
6485:
6483:
6480:
6478:
6475:
6474:
6473:
6470:
6467:
6463:
6460:
6459:
6457:
6455:
6452:
6450:
6445:
6437:
6434:
6432:
6429:
6427:
6424:
6422:
6419:
6417:
6414:
6413:
6412:
6411:
6407:
6403:
6400:
6398:
6395:
6393:
6390:
6389:
6388:
6385:
6381:
6378:
6376:
6373:
6371:
6368:
6366:
6363:
6362:
6361:
6358:
6357:
6355:
6353:
6350:
6348:
6343:
6337:
6334:
6333:
6331:
6329:
6326:
6324:
6319:
6311:
6308:
6306:
6303:
6302:
6301:
6298:
6294:
6291:
6289:
6286:
6284:
6281:
6279:
6276:
6274:
6271:
6269:
6266:
6264:
6261:
6260:
6259:
6256:
6252:
6249:
6247:
6244:
6242:
6239:
6237:
6234:
6232:
6229:
6227:
6224:
6222:
6219:
6217:
6214:
6212:
6209:
6208:
6207:
6204:
6202:
6199:
6193:
6190:
6188:
6185:
6183:
6180:
6178:
6175:
6174:
6173:
6170:
6166:
6163:
6161:
6158:
6157:
6156:
6153:
6149:
6146:
6145:
6144:
6141:
6140:
6139:
6136:
6135:
6133:
6131:
6128:
6126:
6121:
6117:
6113:
6112:Miscellaneous
6108:
6104:
6090:
6089:Shaker (gene)
6087:
6083:
6080:
6078:
6075:
6073:
6070:
6069:
6068:
6065:
6063:
6062:minK/ISK-like
6060:
6058:
6055:
6051:
6048:
6046:
6043:
6041:
6038:
6036:
6033:
6032:
6031:
6028:
6024:
6021:
6019:
6016:
6014:
6011:
6010:
6009:
6002:
6001:
5996:
5993:
5991:
5988:
5986:
5983:
5982:
5981:
5977:
5974:
5972:
5969:
5967:
5964:
5963:
5962:
5958:
5955:
5953:
5950:
5949:
5948:
5944:
5941:
5939:
5936:
5934:
5931:
5930:
5929:
5925:
5922:
5920:
5917:
5916:
5915:
5911:
5908:
5906:
5903:
5901:
5898:
5896:
5893:
5891:
5888:
5887:
5886:
5879:
5878:
5873:
5870:
5868:
5865:
5863:
5860:
5858:
5855:
5854:
5853:
5849:
5846:
5845:
5844:
5840:
5837:
5835:
5832:
5830:
5827:
5826:
5825:
5821:
5818:
5816:
5813:
5811:
5808:
5806:
5803:
5802:
5801:
5797:
5794:
5792:
5789:
5788:
5787:
5783:
5780:
5778:
5775:
5773:
5770:
5768:
5765:
5763:
5760:
5758:
5755:
5753:
5750:
5748:
5745:
5744:
5743:
5736:
5735:
5733:
5731:
5730:Voltage-gated
5727:
5719:
5716:
5714:
5711:
5709:
5706:
5704:
5701:
5699:
5696:
5694:
5691:
5689:
5686:
5684:
5681:
5679:
5676:
5674:
5671:
5669:
5666:
5664:
5661:
5659:
5656:
5654:
5651:
5649:
5646:
5645:
5644:
5641:
5640:
5638:
5636:
5632:
5624:
5621:
5619:
5616:
5614:
5611:
5609:
5606:
5604:
5601:
5599:
5596:
5595:
5594:
5588:
5584:
5581:
5579:
5576:
5574:
5571:
5569:
5566:
5565:
5564:
5557:
5554:
5550:
5547:
5545:
5542:
5540:
5537:
5535:
5532:
5530:
5527:
5525:
5522:
5521:
5520:
5514:
5512:
5506:
5505:
5503:
5501:
5497:
5489:
5486:
5484:
5481:
5479:
5476:
5474:
5471:
5469:
5466:
5464:
5461:
5459:
5456:
5454:
5451:
5450:
5449:
5443:
5439:
5436:
5435:
5433:
5429:
5426:
5424:
5421:
5419:
5416:
5415:
5414:
5411:
5407:
5404:
5402:
5399:
5397:
5394:
5392:
5389:
5387:
5384:
5383:
5382:
5379:
5378:
5376:
5374:
5370:
5366:
5362:
5359:
5354:
5350:
5334:
5331:
5329:
5326:
5324:
5321:
5319:
5316:
5315:
5314:
5307:
5303:
5300:
5298:
5295:
5293:
5290:
5288:
5285:
5283:
5280:
5278:
5275:
5273:
5270:
5268:
5265:
5263:
5260:
5258:
5255:
5254:
5253:
5246:
5245:
5243:
5241:
5240:Voltage-gated
5237:
5229:
5226:
5224:
5221:
5219:
5216:
5214:
5211:
5210:
5209:
5206:
5205:
5203:
5200:
5196:
5188:
5185:
5183:
5180:
5178:
5175:
5173:
5170:
5169:
5168:
5165:
5164:
5162:
5158:
5154:
5150:
5147:
5142:
5138:
5122:
5119:
5117:
5114:
5113:
5112:
5109:
5105:
5102:
5100:
5097:
5095:
5092:
5090:
5087:
5086:
5085:
5082:
5081:
5076:
5073:
5071:
5068:
5066:
5063:
5061:
5058:
5057:
5056:
5053:
5049:
5046:
5044:
5041:
5039:
5036:
5034:
5031:
5030:
5029:
5026:
5022:
5019:
5017:
5014:
5013:
5012:
5005:
5004:
4999:
4996:
4994:
4991:
4989:
4986:
4985:
4984:
4976:
4973:
4971:
4963:
4960:
4958:
4950:
4947:
4943:
4940:
4939:
4938:
4930:
4927:
4925:
4917:
4914:
4910:
4907:
4905:
4902:
4900:
4897:
4895:
4892:
4891:
4890:
4882:
4879:
4878:
4876:
4874:
4873:Voltage-gated
4870:
4862:
4859:
4857:
4854:
4852:
4849:
4848:
4847:
4844:
4840:
4837:
4835:
4832:
4830:
4827:
4826:
4825:
4822:
4821:
4819:
4815:
4811:
4807:
4804:
4799:
4795:
4790:
4786:
4782:
4775:
4770:
4768:
4763:
4761:
4756:
4755:
4752:
4738:
4732:
4727:
4723:
4717:
4712:
4708:
4702:
4697:
4693:
4684:
4679:
4677:
4672:
4670:
4665:
4664:
4661:
4654:
4650:
4643:
4640:
4636:
4633:
4632:
4628:
4620:
4616:
4612:
4608:
4605:(7): 2313–9.
4604:
4600:
4592:
4589:
4584:
4580:
4576:
4572:
4568:
4564:
4557:
4554:
4549:
4545:
4541:
4537:
4533:
4529:
4525:
4521:
4514:
4511:
4506:
4502:
4498:
4494:
4490:
4486:
4482:
4478:
4471:
4468:
4463:
4459:
4455:
4451:
4447:
4443:
4435:
4432:
4427:
4423:
4418:
4413:
4409:
4405:
4401:
4394:
4391:
4386:
4382:
4377:
4372:
4367:
4362:
4358:
4354:
4351:(12): e4009.
4350:
4346:
4342:
4331:
4328:
4323:
4319:
4314:
4309:
4305:
4301:
4297:
4293:
4289:
4282:
4279:
4274:
4270:
4267:(6): 1672–9.
4266:
4262:
4250:
4247:
4242:
4238:
4234:
4230:
4227:(6): 1161–4.
4226:
4222:
4210:
4207:
4202:
4198:
4194:
4190:
4187:(2): 99–107.
4186:
4182:
4170:
4167:
4162:
4158:
4153:
4148:
4144:
4140:
4137:(7): 558–67.
4136:
4132:
4128:
4121:
4118:
4113:
4109:
4105:
4101:
4097:
4093:
4089:
4085:
4074:
4071:
4066:
4062:
4057:
4052:
4048:
4044:
4040:
4029:
4026:
4021:
4017:
4012:
4007:
4003:
3999:
3996:(4): 762–73.
3995:
3991:
3987:
3975:
3972:
3967:
3963:
3958:
3953:
3949:
3945:
3941:
3930:
3927:
3922:
3918:
3913:
3908:
3904:
3900:
3896:
3889:
3886:
3881:
3877:
3872:
3867:
3863:
3859:
3855:
3844:
3841:
3836:
3832:
3828:
3824:
3819:
3814:
3811:(4): 317–20.
3810:
3806:
3802:
3795:
3792:
3787:
3783:
3779:
3775:
3771:
3767:
3759:
3756:
3751:
3747:
3743:
3739:
3735:
3731:
3727:
3723:
3711:
3708:
3703:
3699:
3695:
3691:
3686:
3681:
3677:
3673:
3669:
3662:
3659:
3654:
3650:
3646:
3642:
3638:
3634:
3630:
3626:
3622:
3618:
3614:
3607:
3604:
3599:
3595:
3591:
3587:
3582:
3577:
3573:
3569:
3565:
3553:
3550:
3545:
3541:
3537:
3533:
3529:
3525:
3522:(1): 354–62.
3521:
3517:
3509:
3506:
3501:
3497:
3492:
3487:
3482:
3477:
3473:
3469:
3465:
3454:
3451:
3446:
3442:
3437:
3432:
3427:
3422:
3418:
3414:
3410:
3403:
3401:
3397:
3392:
3388:
3383:
3378:
3374:
3370:
3366:
3362:
3358:
3347:
3345:
3343:
3339:
3334:
3330:
3325:
3320:
3316:
3312:
3308:
3304:
3300:
3289:
3286:
3281:
3277:
3272:
3267:
3263:
3259:
3255:
3244:
3241:
3236:
3232:
3228:
3224:
3220:
3216:
3211:
3206:
3203:(6): 488–99.
3202:
3198:
3191:
3189:
3185:
3180:
3176:
3171:
3166:
3161:
3156:
3152:
3148:
3145:(9): 3112–7.
3144:
3140:
3136:
3125:
3122:
3117:
3113:
3108:
3103:
3099:
3095:
3091:
3080:
3077:
3072:
3068:
3063:
3058:
3054:
3050:
3046:
3042:
3038:
3027:
3024:
3019:
3015:
3011:
3007:
3000:
2997:
2992:
2988:
2983:
2978:
2974:
2970:
2966:
2962:
2958:
2947:
2944:
2939:
2935:
2930:
2925:
2922:(2): 988–97.
2921:
2917:
2913:
2906:
2903:
2898:
2894:
2889:
2884:
2880:
2876:
2872:
2868:
2864:
2853:
2850:
2845:
2841:
2836:
2831:
2826:
2821:
2817:
2813:
2809:
2805:
2801:
2794:
2792:
2788:
2783:
2779:
2774:
2769:
2764:
2759:
2755:
2751:
2747:
2743:
2739:
2728:
2725:
2720:
2716:
2711:
2706:
2702:
2698:
2694:
2690:
2686:
2679:
2676:
2671:
2667:
2662:
2657:
2652:
2647:
2643:
2639:
2635:
2628:
2625:
2620:
2616:
2611:
2606:
2602:
2598:
2594:
2583:
2580:
2575:
2571:
2566:
2561:
2557:
2553:
2549:
2542:
2539:
2534:
2530:
2525:
2520:
2515:
2510:
2506:
2502:
2498:
2494:
2490:
2479:
2477:
2473:
2468:
2464:
2459:
2458:11577/1483621
2454:
2449:
2444:
2440:
2436:
2432:
2425:
2423:
2419:
2414:
2410:
2405:
2400:
2396:
2392:
2389:(4): 602–14.
2388:
2384:
2380:
2369:
2367:
2365:
2363:
2359:
2354:
2350:
2345:
2340:
2335:
2330:
2326:
2322:
2318:
2314:
2310:
2298:
2296:
2294:
2292:
2290:
2288:
2286:
2284:
2282:
2278:
2273:
2269:
2264:
2259:
2254:
2249:
2245:
2241:
2237:
2233:
2229:
2218:
2215:
2210:
2206:
2201:
2196:
2193:(2): 776–86.
2192:
2188:
2184:
2177:
2175:
2171:
2166:
2162:
2157:
2152:
2148:
2144:
2140:
2136:
2132:
2121:
2119:
2117:
2115:
2111:
2106:
2102:
2097:
2092:
2088:
2084:
2080:
2076:
2072:
2065:
2063:
2061:
2059:
2055:
2050:
2046:
2042:
2038:
2035:(2): 163–72.
2034:
2030:
2023:
2020:
2015:
2011:
2007:
2003:
1999:
1995:
1991:
1987:
1983:
1976:
1973:
1968:
1964:
1960:
1956:
1952:
1948:
1944:
1940:
1933:
1930:
1925:
1921:
1916:
1911:
1907:
1903:
1900:(2): 369–85.
1899:
1895:
1891:
1884:
1881:
1876:
1872:
1868:
1864:
1860:
1856:
1852:
1848:
1844:
1840:
1833:
1830:
1825:
1821:
1817:
1813:
1809:
1805:
1801:
1797:
1793:
1789:
1782:
1779:
1774:
1770:
1766:
1762:
1758:
1754:
1750:
1746:
1738:
1735:
1730:
1726:
1721:
1716:
1711:
1706:
1702:
1698:
1694:
1690:
1686:
1679:
1677:
1673:
1668:
1662:
1660:
1656:
1651:
1647:
1641:
1638:
1633:
1629:
1623:
1620:
1616:
1612:
1607:
1605:
1603:
1599:
1595:
1591:
1586:
1584:
1582:
1578:
1572:
1568:
1565:
1564:
1560:
1558:
1556:
1552:
1548:
1544:
1540:
1536:
1528:
1524:
1520:
1516:
1512:
1508:
1504:
1500:
1496:
1492:
1491:charybdotoxin
1488:
1484:
1472:
1470:
1446:
1444:
1442:
1434:
1430:
1426:
1422:
1410:
1408:
1402:
1398:
1393:
1387:
1375:
1367:
1363:
1351:
1343:
1338:
1336:
1330:
1322:
1318:
1314:
1305:
1287:
1286:interleukin 2
1283:
1279:
1272:Blockade of K
1270:
1260:
1256:
1252:
1249:3.1 regulate
1240:
1236:
1227:
1201:
1197:
1193:
1181:
1180:B lymphocytes
1177:
1169:
1162:
1160:
1158:
1154:
1150:
1146:
1142:
1138:
1133:
1131:
1126:
1122:
1118:
1116:
1113:
1109:
1105:
1097:
1093:
1081:
1076:
1072:
1068:
1065:
1061:
1054:
1052:
1049:
1045:
1041:
1037:
1034:
1030:
1026:
1019:
1017:
1011:
1007:
1004:
998:
996:
990:
986:
983:
979:
972:
970:
964:
960:
957:
951:
949:
943:
939:
936:
934:RefSeq (mRNA)
932:
925:
924:
919:
915:
912:
906:
905:
900:
896:
893:
891:
887:
880:
879:
874:
870:
867:
861:
860:
855:
851:
848:
846:
842:
835:
834:
829:
825:
822:
816:
815:
810:
806:
803:
801:
797:
794:
791:
789:
786:
782:
779:
775:
771:
764:
760:
755:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
723:ion transport
721:
719:
716:
715:
713:
710:
709:
703:
700:
698:
695:
693:
690:
688:
687:calyx of Held
685:
683:
680:
678:
677:membrane raft
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
649:
647:
644:
643:
637:
634:
632:
629:
627:
624:
622:
619:
617:
614:
612:
609:
607:
604:
603:
601:
598:
597:
594:
593:Gene ontology
590:
586:
574:
569:
565:
560:
557:
555:
551:
543:
538:
527:
523:
519:
515:
511:
507:
503:
499:
495:
491:
490:
487:
483:
478:
475:
465:
461:
457:
453:
449:
445:
441:
437:
433:
429:
428:
425:
421:
416:
413:
412:
409:
407:
403:
401:
400:
396:
395:
392:
390:
386:
382:
378:
374:
366:
361:
357:
353:
348:
338:
334:
327:
320:
314:
307:
299:
295:
291:
286:
282:
277:
273:
265:
260:
256:
252:
247:
237:
233:
226:
219:
213:
206:
202:
196:
192:
188:
183:
179:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
122:
117:
110:
105:
100:
89:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
7021:Ion channels
6993:
6992:
6980:
6947:Ligand-gated
6938:
6926:
6769:Gap junction
6762:
6651:
6447:
6408:
6386:
6359:
6345:
6321:
6299:
6257:
6205:
6171:
6154:
6142:
6123:
6111:
6066:
6029:
6003:
5880:
5756:
5737:
5642:
5589:
5559:
5515:
5444:
5357:
5308:
5247:
5145:
5054:
5027:
5006:
4978:
4965:
4952:
4932:
4919:
4884:
4817:Ligand-gated
4802:
4785:ion channels
4736:
4721:
4706:
4602:
4598:
4591:
4566:
4562:
4556:
4526:(3): 303–5.
4523:
4519:
4513:
4480:
4476:
4470:
4445:
4441:
4434:
4407:
4403:
4393:
4348:
4344:
4330:
4295:
4291:
4281:
4264:
4260:
4249:
4224:
4220:
4209:
4184:
4180:
4169:
4134:
4130:
4120:
4087:
4083:
4073:
4046:
4042:
4028:
3993:
3989:
3974:
3947:
3943:
3929:
3902:
3898:
3888:
3861:
3857:
3843:
3808:
3804:
3794:
3769:
3765:
3758:
3725:
3721:
3710:
3675:
3671:
3661:
3620:
3616:
3606:
3571:
3567:
3552:
3519:
3515:
3508:
3471:
3467:
3453:
3416:
3412:
3364:
3360:
3306:
3302:
3288:
3264:(2): 654–8.
3261:
3257:
3243:
3200:
3196:
3142:
3138:
3124:
3100:(5): 551–9.
3097:
3093:
3079:
3044:
3040:
3026:
3012:(5): 640–7.
3009:
3005:
2999:
2964:
2960:
2946:
2919:
2915:
2905:
2870:
2866:
2852:
2807:
2803:
2745:
2741:
2727:
2692:
2688:
2678:
2641:
2637:
2627:
2600:
2596:
2582:
2555:
2551:
2541:
2496:
2492:
2438:
2434:
2386:
2382:
2316:
2312:
2235:
2231:
2217:
2190:
2186:
2138:
2134:
2081:(5): 280–9.
2078:
2074:
2032:
2028:
2022:
1989:
1985:
1975:
1942:
1938:
1932:
1897:
1893:
1883:
1842:
1838:
1832:
1791:
1787:
1781:
1748:
1744:
1737:
1692:
1688:
1649:
1640:
1631:
1622:
1476:
1450:
1414:
1394:
1347:
1306:
1280:production (
1271:
1259:CRAC channel
1228:
1198:and central
1192:3.1 channels
1167:
1166:
1134:
1119:
1111:
1099:
1095:
1091:
1090:
1013:
992:
966:
945:
921:
902:
876:
857:
831:
812:
792:
787:
404:
397:
363:106,945,386
350:106,943,485
262:110,674,940
249:110,672,465
124:External IDs
83:
6952:Light-gated
5434:IK channel
4689:PDB gallery
4483:(1): 93–6.
1527:clofazimine
1499:anuroctoxin
1495:noxiustoxin
446:granulocyte
102:Identifiers
7010:Categories
6155:Bestrophin
5413:SK channel
5381:BK channel
5055:γ-subunits
5028:β-subunits
5011:δ-subunits
3474:(1): 128.
1617:, May 2017
1596:, May 2017
1573:References
1523:correolide
1487:kaliotoxin
1483:margatoxin
1344:Autoimmune
1327:1.3 via a
1149:intronless
1130:Drosophila
442:lymph node
408:(ortholog)
145:HomoloGene
6983:disorders
6981:see also
6764:Cytoplasm
6674:Aquaporin
6143:Anoctamin
5966:11.1/hERG
3645:0041-0101
3419:(1): 24.
3205:CiteSeerX
1773:219195192
1411:Metabolic
1401:chlamydia
1397:influenza
1265:1.3 and K
1245:1.3 and K
1214:1.3 and K
1016:NP_032444
995:NP_002223
969:NM_008418
948:NM_002232
778:Orthologs
153:GeneCards
6777:Connexin
6057:minK/ISK
4619:17570206
4548:36255192
4505:43528153
4462:16200586
4385:19104661
4345:PLOS ONE
4241:12643934
4201:10607427
4161:25976092
4104:16099841
4020:19122005
3966:18480054
3921:10419508
3750:12308227
3742:15615696
3702:18538305
3653:18471844
3598:21383597
3536:16234482
3500:28651603
3445:29784049
3391:29272333
3333:25362031
3280:16317062
3235:37002854
3227:15914584
3179:14981264
3116:12588802
3071:18542083
3018:14579513
2991:17273162
2938:17984097
2897:15665253
2844:11717451
2782:16043714
2719:11602626
2670:18940791
2619:12807917
2533:18818304
2467:15632141
2413:18835197
2383:Immunity
2353:17088564
2272:14745040
2209:15240664
2165:12782673
2105:15120495
2014:45657700
1875:30410512
1765:16382104
1613:–
1592:–
1561:See also
1529:). The K
1473:Blockers
1278:cytokine
1163:Function
1064:Wikidata
757:Sources:
652:membrane
458:appendix
450:monocyte
430:testicle
6904:Innexin
6661:solutes
4583:7829710
4497:4851057
4426:9116272
4376:2602975
4353:Bibcode
4322:9802971
4313:2212508
4273:8967992
4152:6495590
4112:6931552
4065:9063464
4011:2684922
3880:9830012
3835:9180663
3827:8599755
3786:8645244
3694:7576659
3625:Bibcode
3617:Toxicon
3590:9164927
3544:8598481
3491:5485721
3436:5963076
3382:5837198
3324:4402159
3147:Bibcode
3062:2737548
2982:1929164
2888:4275123
2812:Bibcode
2773:1182417
2750:Bibcode
2661:2605975
2574:8702786
2524:2567458
2501:Bibcode
2404:2732399
2344:1859943
2321:Bibcode
2240:Bibcode
2096:2749963
2049:1547020
2006:2351830
1967:2305265
1947:Bibcode
1939:Science
1924:6088661
1915:2187449
1867:6320008
1847:Bibcode
1824:4340921
1816:6320007
1796:Bibcode
1729:2251283
1697:Bibcode
1615:Ensembl
1594:Ensembl
1519:Psora-4
1237:during
1108:protein
1106:, is a
890:UniProt
845:Ensembl
784:Species
763:QuickGO
383:pattern
109:Aliases
5201:-gated
5199:Proton
4975:T-type
4962:R-type
4949:Q-type
4929:P-type
4916:N-type
4881:L-type
4655:(MeSH)
4641:(MeSH)
4617:
4581:
4546:
4540:708598
4538:
4503:
4495:
4460:
4424:
4383:
4373:
4320:
4310:
4271:
4239:
4199:
4159:
4149:
4110:
4102:
4063:
4018:
4008:
3964:
3919:
3878:
3833:
3825:
3784:
3748:
3740:
3700:
3692:
3672:Neuron
3651:
3643:
3596:
3588:
3542:
3534:
3498:
3488:
3443:
3433:
3389:
3379:
3331:
3321:
3278:
3233:
3225:
3207:
3177:
3170:365752
3167:
3114:
3069:
3059:
3016:
2989:
2979:
2936:
2895:
2885:
2842:
2832:
2780:
2770:
2717:
2710:209525
2707:
2668:
2658:
2617:
2572:
2531:
2521:
2465:
2411:
2401:
2351:
2341:
2270:
2263:337045
2260:
2207:
2163:
2156:156104
2153:
2103:
2093:
2047:
2012:
2004:
1965:
1922:
1912:
1873:
1865:
1839:Nature
1822:
1814:
1788:Nature
1771:
1763:
1727:
1717:
1541:, and
1329:lysine
1157:KCNA10
1145:T cell
1137:shaker
1050:search
1048:PubMed
923:P16390
904:P22001
800:Entrez
554:BioGPS
508:embryo
504:embryo
492:thymus
241:1p13.3
149:128570
133:176263
6815:GJA10
6666:Porin
6566:TRPML
6336:HVCN1
6030:KCNIP
5885:α7-12
4789:TC 1A
4544:S2CID
4501:S2CID
4404:Blood
4108:S2CID
3831:S2CID
3746:S2CID
3698:S2CID
3594:S2CID
3540:S2CID
3361:Brain
3231:S2CID
2835:61146
2010:S2CID
1871:S2CID
1820:S2CID
1769:S2CID
1720:55175
1515:PAP-1
1366:GAD65
1196:naive
1168:KCNA3
1153:KCNA2
1112:KCNA3
1096:KCNA3
833:16491
793:Mouse
788:Human
759:Amigo
454:blood
406:Mouse
399:Human
346:Start
281:Mouse
245:Start
178:Human
157:KCNA3
141:96660
116:KCNA3
33:KCNA3
18:Kv1.3
6895:GJD4
6890:GJD3
6885:GJD2
6875:GJC3
6870:GJC2
6865:GJC1
6855:GJB7
6850:GJB6
6845:GJB5
6840:GJB4
6835:GJB3
6830:GJB2
6825:GJB1
6810:GJA9
6805:GJA8
6800:GJA5
6795:GJA4
6790:GJA3
6785:GJA1
6610:TRPV
6593:TRPP
6588:TRPN
6519:TRPM
6472:TRPC
6462:TRPA
6300:CLNS
6258:CLIC
6206:CLCN
6201:CFTR
6148:ANO1
6067:MiRP
5995:12.3
5990:12.2
5985:12.1
5976:11.3
5971:11.2
5957:10.2
5952:10.1
5742:α1-6
5556:GIRK
4970:α2.3
4957:α2.1
4924:α2.2
4737:1qdw
4722:1qdv
4707:1dsx
4615:PMID
4579:PMID
4536:PMID
4493:PMID
4458:PMID
4422:PMID
4381:PMID
4318:PMID
4269:PMID
4237:PMID
4197:PMID
4157:PMID
4100:PMID
4061:PMID
4016:PMID
3962:PMID
3917:PMID
3876:PMID
3823:PMID
3782:PMID
3738:PMID
3690:PMID
3649:PMID
3641:ISSN
3586:PMID
3532:PMID
3496:PMID
3441:PMID
3387:PMID
3329:PMID
3276:PMID
3223:PMID
3175:PMID
3112:PMID
3067:PMID
3014:PMID
2987:PMID
2934:PMID
2893:PMID
2840:PMID
2778:PMID
2715:PMID
2666:PMID
2615:PMID
2570:PMID
2529:PMID
2463:PMID
2409:PMID
2349:PMID
2268:PMID
2205:PMID
2161:PMID
2101:PMID
2045:PMID
2002:PMID
1963:PMID
1920:PMID
1863:PMID
1812:PMID
1761:PMID
1725:PMID
1503:OdK2
1253:and
1178:and
1155:and
1115:gene
814:3738
672:axon
389:Bgee
337:Band
298:Chr.
236:Band
195:Chr.
129:OMIM
86:4BGC
67:RCSB
64:PDBe
6659:(+
6497:4AP
6410:HCN
5943:9.3
5938:9.2
5933:9.1
5924:8.2
5919:8.1
5910:7.5
5905:7.4
5900:7.3
5895:7.2
5890:7.1
5872:6.4
5867:6.3
5862:6.2
5857:6.1
5848:5.1
5839:4.3
5834:4.2
5829:4.1
5820:3.4
5815:3.3
5810:3.2
5805:3.1
5796:2.2
5791:2.1
5782:1.8
5777:1.7
5772:1.6
5767:1.5
5762:1.4
5757:1.3
5752:1.2
5747:1.1
5643:K2P
5623:7.1
5618:6.2
5613:6.1
5608:5.1
5603:4.2
5598:4.1
5583:3.4
5578:3.3
5573:3.2
5568:3.1
5549:2.6
5544:2.4
5539:2.3
5534:2.2
5529:2.1
5524:1.1
5510:ATP
5488:5.1
5483:4.2
5478:4.1
5473:3.1
5468:2.3
5463:2.2
5458:2.1
5453:1.1
5438:IK1
5428:SK3
5423:SK2
5418:SK1
5297:1.9
5292:1.8
5287:1.7
5282:1.6
5277:1.5
5272:1.4
5267:1.3
5262:1.2
5257:1.1
5146:Na:
4998:3.3
4993:3.2
4988:3.1
4942:2.1
4909:1.4
4904:1.3
4899:1.2
4894:1.1
4803:Ca:
4607:doi
4603:132
4571:doi
4528:doi
4485:doi
4450:doi
4412:doi
4371:PMC
4361:doi
4308:PMC
4300:doi
4296:188
4229:doi
4189:doi
4185:197
4147:PMC
4139:doi
4092:doi
4051:doi
4047:244
4006:PMC
3998:doi
3952:doi
3948:283
3907:doi
3903:274
3866:doi
3862:273
3813:doi
3774:doi
3770:219
3730:doi
3680:doi
3633:doi
3576:doi
3572:158
3524:doi
3486:PMC
3476:doi
3431:PMC
3421:doi
3377:PMC
3369:doi
3365:141
3319:PMC
3311:doi
3266:doi
3215:doi
3165:PMC
3155:doi
3143:101
3102:doi
3057:PMC
3049:doi
2977:PMC
2969:doi
2965:127
2924:doi
2920:283
2883:PMC
2875:doi
2830:PMC
2820:doi
2768:PMC
2758:doi
2746:102
2705:PMC
2697:doi
2693:108
2656:PMC
2646:doi
2642:283
2605:doi
2601:278
2560:doi
2556:271
2519:PMC
2509:doi
2497:105
2453:hdl
2443:doi
2439:280
2399:PMC
2391:doi
2339:PMC
2329:doi
2317:103
2258:PMC
2248:doi
2236:101
2195:doi
2191:173
2151:PMC
2143:doi
2139:111
2091:PMC
2083:doi
2037:doi
1994:doi
1990:144
1955:doi
1943:247
1910:PMC
1902:doi
1898:160
1855:doi
1843:307
1804:doi
1792:307
1753:doi
1715:PMC
1705:doi
1507:ShK
1431:in
1317:Bax
1104:1.3
1098:or
359:End
258:End
161:OMA
137:MGI
57:PDB
7012::
6881:D
6861:C
6821:B
6781:A
6663:):
6416:FC
6310:1B
6305:1A
6293:L1
6251:KB
6246:KA
6125:Cl
5718:18
5713:17
5708:16
5703:15
5698:13
5693:12
5688:10
5592:ir
5562:ir
5518:ir
5447:Ca
5406:β4
5401:β3
5396:β2
5391:β1
5386:α1
5358:K:
5309:Na
5302:7A
5248:Na
5075:γ4
5070:γ3
5065:γ2
5060:γ1
5048:β4
5043:β3
5038:β2
5033:β1
4979:Ca
4966:Ca
4953:Ca
4933:Ca
4920:Ca
4885:Ca
4783::
4613:.
4601:.
4577:.
4567:32
4565:.
4542:.
4534:.
4524:99
4522:.
4499:.
4491:.
4481:91
4479:.
4456:.
4446:52
4444:.
4420:.
4408:89
4406:.
4402:.
4379:.
4369:.
4359:.
4347:.
4343:.
4316:.
4306:.
4294:.
4290:.
4265:50
4263:.
4235:.
4225:13
4223:.
4195:.
4183:.
4155:.
4145:.
4135:21
4133:.
4129:.
4106:.
4098:.
4088:68
4086:.
4059:.
4045:.
4041:.
4014:.
4004:.
3994:75
3992:.
3988:.
3960:.
3946:.
3942:.
3915:.
3901:.
3897:.
3874:.
3860:.
3856:.
3829:.
3821:.
3807:.
3803:.
3780:.
3768:.
3744:.
3736:.
3726:67
3724:.
3696:.
3688:.
3676:15
3674:.
3670:.
3647:.
3639:.
3631:.
3621:51
3619:.
3615:.
3592:.
3584:.
3570:.
3566:.
3538:.
3530:.
3520:69
3518:.
3494:.
3484:.
3472:14
3470:.
3466:.
3439:.
3429:.
3417:13
3415:.
3411:.
3399:^
3385:.
3375:.
3363:.
3359:.
3353:"K
3341:^
3327:.
3317:.
3307:44
3305:.
3301:.
3274:.
3262:91
3260:.
3256:.
3229:.
3221:.
3213:.
3201:84
3199:.
3187:^
3173:.
3163:.
3153:.
3141:.
3137:.
3110:.
3098:12
3096:.
3092:.
3065:.
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