162:, whose degradation is responsible for a large number of debilitating problems. (TMJ disc degeneration and meniscus injuries result in arthritic-like diseases that strike otherwise healthy young adults.) In addition to tissue-level work, Athanasiou has established a program to understand how single cartilage cells behave under direct and controlled biomechanical loads, not only in terms of deformation but also in terms of changes in gene expression. This work represents the first measurement of gene levels at the single cell level under varying biomechanical conditions. His group has also demonstrated the fabrication of entire sections of articular cartilage by self-assembly of cells, without the use of any scaffolds. Their group also demonstrated that hydrostatic pressure in conjunction with growth factors can have synergistic effects on the functional properties of engineered cartilage. The biomechanical, histological, transcriptional, and biochemical properties of this engineered cartilage approach those of native articular cartilage. More recently, the Athanasiou group showed the engineering of articular cartilage with biomechanical tensile properties on par with native tissue; the work was published in
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In addition to his academic accomplishments, Athanasiou is known for his significant contributions in co-founding fifteen companies based on technologies co-developed by his group. His first company
Osteobiologics, founded in 1993, was based, among other inventions, on the development of acellular
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Makris, E.A.; Responte, D.J.; Paschos, N.K.; Hu, J.; Athanasiou, K.A.: Developing functional musculoskeletal tissues through hypoxia and lysyl oxidase-induced collagen crosslinking, PNAS (Proceedings of the
National Academy of Sciences), DOI/10.1073/pnas.1414271111,
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1.Lee, J.K. (co-first); Huwe, L.Y. (co-first); Paschos, N.P.; Aryaei, A.; Gegg, C.; Hu, J.C.; Athanasiou, K.A.: Tension stimulation drives tissue formation in scaffold-free systems, Nature
Materials, 10.1038/nmat4917,
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at the end of 1999. Athanasiou established a research group in bioengineering, specializing in the cartilages of the musculoskeletal system. His group has worked extensively on cartilages of the
78:. During that time, he trained at an infantry cadet school eventually becoming a second lieutenant. In August 1980, he came to the United States to attend college. He spent his first year at
74:, Cyprus in 1960. He went to Sotir Elementary School and St. George High School. In 1978, he graduated valedictorian from high school and then joined the army for 26 months as part of his
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Athanasiou, K.A.; Korvick, D.; Schenck, R.C.: Biodegradable implants for the treatment of osteochondral defects in a goat model. Tissue
Engineering, Vol. 3(4): 363-374, 1997.
34:-American bioengineer who has contributed significantly to both academic advancements as well as high-technology industries. He is currently a Distinguished Professor at the
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where he also served as the Chair of the
Biomedical Engineering department. Before joining the University of California in 2009, he was the Karl F. Hasselmann Professor at
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Leipzig, N.; Athanasiou, K.A.: Static compression of single chondrocytes catabolically modifies single cell gene expression. Biophysical
Journal, 94(6):2412-2422, 2008
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Athanasiou showed that the matrix of a number of musculoskeletal tissues can be crosslinked with exogenous methods using lysyl oxidase L2. In a paper published in
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both in terms of characterization but also in efforts to achieve healing or repair of the clinically complex problems of cartilage afflictions, including
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Elder, B.D.; Athanasiou, K.A.: Synergistic and additive effects of hydrostatic pressure and growth factors on tissue formation. PLoS ONE, 3(6): e2341.
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Huey, D.; Hu, J.C.; Athanasiou, K.A.: Unlike bone, cartilage regeneration remains elusive, Science, 338:917-921, DOI: 10.1126/science.1222454, 2012
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scaffolds for the treatment of focal cartilage lesions. This was the first ever implant for this application. The company was acquired by
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Hu, J.C.; Athanasiou, K.A.: A self-assembling process in articular cartilage tissue engineering. Tissue
Engineering, 12(4):969-979, 2006
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148:. He published one of the first papers on the use of biodegradable scaffolds as carriers of growth factors to heal cartilage defects
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210:. He served as BMES President from 2003 through 2004. He has also served as editor-in-chief of the Society's flagship journal, the
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Athanasiou, K.A.; Darling, E.; DuRaine, G.; Hu, J.; Reddi, A.H.: Articular
Cartilage, Second Edition,
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620:"Pedro Pascal and World Bank's Ajay Banga among those named to Carnegie's 2023 Great Immigrants list"
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based on
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Upon obtaining his Ph.D. in early 1989, Athanasiou became an assistant professor at the
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Athanasiou received his bachelor's degree in
Mechanical Engineering from
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Fellows of the American Institute for Medical and Biological Engineering
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Among other awards and recognitions, Athanasiou has been elected to the
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the Athanasiou group described why cartilage healing is so difficult.
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Fellows of the American Association for the Advancement of Science
121:. He became an associate professor in 1994. He was recruited to
593:"Bioengineer Athanasiou among biomedical society's first fellows"
503:"Kyriacos A. Athanasiou Elected to National Academy of Medicine"
272:. University of California, Irvine, Office of Academic Personnel
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In the summer of 2002, Athanasiou was elected President of the
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Columbia School of Engineering and Applied Science alumni
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University of Texas Health Science Center at San Antonio
443:"Athanasiou next president of biomedical organization"
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in 2006. Another company co-founded by Athanasiou is
505:. University of California, Irvine. October 22, 2020
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American Association for the Advancement of Science
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American Association for the Advancement of Science
101:where he obtained his master's degree in 1985, his
360:Ofek, G.; Revell, C.M.; Hu, J.C.; Allison, D.D.;
292:"New biomed engineering chair thrives on 'change'"
144:Athanasiou and his colleagues published the book
202:Service to the biomedical engineering profession
95:New York Institute of Technology at Old Westbury
168:Proceedings of the National Academy of Sciences
722:Fellows of the Biomedical Engineering Society
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727:Members of the National Academy of Medicine
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667:American people of Greek Cypriot descent
579:American Society of Mechanical Engineers
235:American Society of Mechanical Engineers
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86:. He then moved in with relatives in
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245:Honoree; the award was given by the
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551:"AAAS Members Elected as Fellows"
290:Parker, Clifton B. (2009-09-25).
212:Annals of Biomedical Engineering.
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36:University of California, Irvine
482:Springer Science+Business Media
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40:University of California, Davis
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166:. In a study published in the
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16:Cypriot-American bioengineer
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97:in 1984. He then attended
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181:High-technology companies
38:. He joined UCI from the
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229:. He is a Fellow of the
66:Early life and education
697:Rice University faculty
474:2015 Media Information"
125:as a full professor of
76:mandatory military duty
70:Athanasiou was born in
60:temporomandibular joint
243:Great Immigrants Award
241:. In 2023 he became a
131:musculoskeletal system
20:Kyriacos A. Athanasiou
677:American bioengineers
525:"Current NAI Fellows"
270:Titles of distinction
682:People from Larnaca
571:"ASME Fellows List"
146:Articular Cartilage
99:Columbia University
84:Owensboro, Kentucky
52:articular cartilage
362:Grande-Allen, K.J.
188:Smith & Nephew
48:tissue engineering
30:; born 1960) is a
28:Κυριάκος Αθανασίου
324:, CRC Press, 2017
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105:in 1987, and his
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253:References
237:, and the
158:) and the
58:, and the
198:in 2013.
109:in 1989.
225:and the
192:Vidacare
156:TMJ disc
113:Research
624:AP News
509:July 7,
396:, 2008
372:, 2008
173:Science
151:in vivo
72:Larnaca
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233:, the
217:Honors
135:trauma
54:, the
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24:Greek
511:2021
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107:Ph.D
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