Knowledge (XXG)

KLK1

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proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.
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Richards RI, Holman K, Shen Y, Kozman H, Harley H, Brook D, Shaw D (Feb 1992). "Human glandular Kallikrein genes: genetic and physical mapping of the KLK1 locus using a highly polymorphic microsatellite PCR marker".
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Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006).
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Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005".
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Henttu P, Lukkarinen O, Vihko P (1990). "Expression of the gene coding for human prostate-specific antigen and related hGK-1 in benign and malignant tumors of the human prostate".
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Lottspeich F, Geiger R, Henschen A, Kutzbach C (1980). "N-Terminal amino acid sequence of human urinary kallikrein homology with other serine proteases".
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Qin H, Kemp J, Yip MY, et al. (1992). "Localization of human glandular kallikrein-1 gene to chromosome 19q13.3-13.4 by in situ hybridization".
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Chen VC, Chao L, Chao J (2000). "Reactive-site specificity of human kallistatin toward tissue kallikrein probed by site-directed mutagenesis".
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Gomes RA, Juliano L, Chagas JR, Hial V (1997). "Characterization of kininogenase activity of an acidic proteinase isolated from human kidney".
2528: 1953: 1687:"Evaluation of the extent of the binding site in human tissue kallikrein by synthetic substrates with sequences of human kininogen fragments" 1606:
Kellermann J, Lottspeich F, Geiger R, Deutzmann R (1988). "Human urinary kallikrein--amino acid sequence and carbohydrate attachment sites".
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Lin FK, Lin CH, Chou CC, et al. (1993). "Molecular cloning and sequence analysis of the monkey and human tissue kallikrein genes".
301: 962: 969: 278: 1297: 1118: 1097: 1982:: STRUCTURE OF MATURE HUMAN TISSUE KALLIKREIN (HUMAN KALLIKREIN 1 OR KLK1) AT 1.70 ANGSTROM RESOLUTION WITH VACANT ACTIVE SITE 2000: 1548:
Evans BA, Yun ZX, Close JA, et al. (1988). "Structure and chromosomal localization of the human renal kallikrein gene".
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Lu HS, Lin FK, Chao L, Chao J (1989). "Human urinary kallikrein. Complete amino acid sequence and sites of glycosylation".
1318:"The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions" 52: 1093: 2234: 117: 1852:"Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2" 1064: 1627:
Takahashi S, Irie A, Katayama Y, et al. (1986). "N-terminal amino acid sequence of human urinary prokallikrein".
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Fukushima D, Kitamura N, Nakanishi S (1986). "Nucleotide sequence of cloned cDNA for human pancreatic kallikrein".
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Riegman PH, Vlietstra RJ, Suurmeijer L, et al. (1992). "Characterization of the human kallikrein locus".
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Clements J, Mukhtar A, Ehrlich A, Yap B (1995). "Glandular kallikrein gene expression in the human uterus".
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This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-
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Baker AR, Shine J (1986). "Human kidney kallikrein: cDNA cloning and sequence analysis".
1754: 1729: 1711: 1686: 1531: 1506: 1489: 1206:"A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" 1898: 1394: 661: 656: 651: 635: 630: 625: 609: 604: 599: 594: 28: 2522: 2475: 2429: 2302: 2291: 2023: 1805: 1181: 581: 1730:"Molecular cloning, purification and in situ localization of human colon kallikrein" 1439: 1283: 2325: 2219: 2061: 1352: 387: 166: 129: 1240: 153: 2444: 2439: 2088: 1154:
National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
1069: 1507:"Cloning and expression of human salivary-gland kallikrein in Escherichia coli" 470: 2406: 2348: 2129: 2124: 2104: 1048: 286: 183: 133: 1868: 1851: 2434: 2420: 2239: 2119: 2109: 691: 530: 408: 353: 340: 252: 239: 141: 1906: 1669: 1423: 1344: 1275: 1232: 1877: 1842: 1834: 1813: 1784: 1763: 1720: 1677: 1648: 1619: 1598: 1569: 1540: 1497: 1468: 1431: 1402: 1189: 1009: 1004: 2320: 2315: 2264: 2114: 2099: 2066: 1373: 993: 836: 817: 1590: 1561: 1336: 1267: 1224: 2374: 2364: 2310: 2224: 2056: 1025: 803: 758: 1745: 1702: 1522: 1460: 74: 2401: 2343: 1922: 1043: 977: 713: 2463: 2410: 2396: 2335: 2209: 2204: 2199: 2194: 2189: 2184: 1850:
Bourgeois L, Brillard-Bourdet M, Deperthes D, et al. (1997).
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Del Nery E, Chagas JR, Juliano MA, et al. (1996).
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online database for peptidases and their inhibitors:
542: 2357: 2334: 2300: 2250: 2087: 2042: 930: 909: 875: 854: 1110: 1108: 1106: 1089: 1087: 1085: 324: 223: 1316:Clements J, Hooper J, Dong Y, Harvey T (2001). 16:Protein-coding gene in the species Homo sapiens 1115:GRCm38: Ensembl release 89: ENSMUSG00000063903 657:regulation of systemic arterial blood pressure 2503: 2008: 1947: 1728:Chen LM, Richards GP, Chao L, Chao J (1995). 1505:Angermann A, Bergmann C, Appelhans H (1990). 8: 1094:GRCh38: Ensembl release 89: ENSG00000167748 2510: 2496: 2015: 2001: 1993: 1954: 1940: 1932: 687: 577: 365: 264: 161: 63: 1867: 1753: 1710: 1530: 1969: 1081: 2028:serine proteases/serine endopeptidases 509:crypt of lieberkuhn of small intestine 18: 1641:10.1093/oxfordjournals.jbchem.a135563 329: 290: 285: 228: 187: 182: 7: 2460: 2458: 2482:. You can help Knowledge (XXG) by 1490:10.1111/j.1399-3011.1989.tb01277.x 927: 906: 872: 851: 827: 808: 782: 763: 737: 718: 605:serine-type endopeptidase activity 547: 465: 403: 382: 14: 1028:that in humans is encoded by the 2462: 1972: 1298:"Entrez Gene: KLK1 kallikrein 1" 551: 313: 306: 300: 277: 212: 205: 199: 174: 27: 1362:Hoppe-Seyler's Z. Physiol. Chem 108:, KLKR, Klk6, hK1, kallikrein 1 2544:Human chromosome 19 gene stubs 1053:low molecular weight kininogen 1042:Kallikreins are a subgroup of 600:serine-type peptidase activity 562:More reference expression data 531:More reference expression data 1: 2240:Urinary plasminogen activator 1899:10.1016/S0167-4838(00)00044-3 1395:10.1016/S0888-7543(05)80275-7 298: 197: 2529:Genes on human chromosome 19 2235:Tissue plasminogen activator 1806:10.1016/0167-4781(93)90131-v 1182:10.1016/0888-7543(91)90103-L 2560: 2457: 1823:Can. J. Physiol. Pharmacol 1035:. KLK1 is a member of the 423:mucosa of transverse colon 2326:Proteinase 3/Myeloblastin 1967: 1478:Int. J. Pept. Protein Res 1150:"Mouse PubMed Reference:" 1132:"Human PubMed Reference:" 1008: 1003: 999: 992: 976: 957: 934: 913: 902: 879: 858: 847: 834: 830: 815: 811: 802: 789: 785: 770: 766: 757: 744: 740: 725: 721: 712: 697: 690: 686: 670: 580: 576: 559: 550: 541: 528: 477: 468: 415: 406: 376: 368: 364: 347: 334: 297: 276: 267: 263: 246: 233: 196: 173: 164: 160: 115: 112: 102: 95: 90: 71: 66: 49: 44: 39: 35: 26: 21: 1869:10.1074/jbc.272.47.29590 963:Chr 19: 50.82 – 50.82 Mb 1773:Braz. J. Med. Biol. Res 1065:Kinin–kallikrein system 970:Chr 7: 43.87 – 43.88 Mb 2380:Proprotein convertases 1887:Biochim. Biophys. Acta 1794:Biochim. Biophys. Acta 1670:10.1089/dna.1985.4.445 1608:Protein Seq. Data Anal 1424:10.1002/ijc.2910450414 2230:Plasminogen activator 1835:10.1139/cjpp-75-6-757 626:extracellular exosome 190:Chromosome 19 (human) 2370:Prolyl endopeptidase 331:7 B3|7 28.74 cM 292:Chromosome 7 (mouse) 67:List of PDB id codes 40:Available structures 1591:10.1021/bi00348a030 1562:10.1021/bi00409a003 1337:10.1515/BC.2001.002 1268:10.1515/BC.2006.081 1225:10.1515/BC.2006.082 1037:peptidase S1 family 517:islet of Langerhans 481:submandibular gland 439:islet of Langerhans 2470:This article on a 792:ENSMUSG00000063903 662:zymogen activation 645:Biological process 619:Cellular component 610:hydrolase activity 595:peptidase activity 588:Molecular function 2491: 2490: 2455: 2454: 2252:Complement system 2044:Digestive enzymes 1990: 1989: 1746:10.1042/bj3070481 1703:10.1042/bj3120233 1523:10.1042/bj2620787 1461:10.1159/000154005 1019: 1018: 1015: 1014: 988: 987: 953: 952: 924: 923: 898: 897: 869: 868: 843: 842: 824: 823: 798: 797: 779: 778: 753: 752: 734: 733: 682: 681: 636:secretory granule 572: 571: 568: 567: 537: 536: 524: 523: 462: 461: 360: 359: 259: 258: 86: 85: 82: 81: 50:Ortholog search: 2551: 2512: 2505: 2498: 2466: 2459: 2017: 2010: 2003: 1994: 1976: 1956: 1949: 1942: 1933: 1910: 1881: 1871: 1846: 1817: 1788: 1767: 1757: 1724: 1714: 1681: 1652: 1623: 1602: 1573: 1544: 1534: 1501: 1472: 1443: 1406: 1377: 1356: 1322: 1302: 1301: 1294: 1288: 1287: 1251: 1245: 1244: 1210: 1200: 1194: 1193: 1164: 1158: 1157: 1146: 1140: 1139: 1128: 1122: 1112: 1101: 1091: 1001: 1000: 972: 965: 948: 928: 919: 907: 903:RefSeq (protein) 893: 873: 864: 852: 828: 809: 783: 764: 738: 719: 688: 578: 564: 555: 548: 533: 473: 471:Top expressed in 466: 419:body of pancreas 411: 409:Top expressed in 404: 383: 366: 356: 343: 332: 317: 310: 304: 293: 281: 265: 255: 242: 231: 216: 209: 203: 192: 178: 162: 156: 154:KLK1 - orthologs 107: 100: 77: 64: 58: 37: 36: 31: 19: 2559: 2558: 2554: 2553: 2552: 2550: 2549: 2548: 2519: 2518: 2517: 2516: 2456: 2451: 2353: 2330: 2296: 2246: 2083: 2052:Enteropeptidase 2038: 2021: 1991: 1986: 1983: 1977: 1963: 1960: 1918: 1913: 1893:(1–2): 237–46. 1884: 1862:(47): 29590–5. 1849: 1820: 1791: 1770: 1727: 1684: 1655: 1626: 1605: 1585:(27): 8037–43. 1576: 1547: 1504: 1475: 1446: 1409: 1380: 1368:(12): 1947–50. 1359: 1320: 1315: 1311: 1309:Further reading 1306: 1305: 1296: 1295: 1291: 1253: 1252: 1248: 1208: 1202: 1201: 1197: 1166: 1165: 1161: 1148: 1147: 1143: 1130: 1129: 1125: 1113: 1104: 1092: 1083: 1078: 1061: 1010:View/Edit Mouse 1005:View/Edit Human 968: 961: 958:Location (UCSC) 944: 940: 936: 915: 889: 885: 881: 860: 773:ENSG00000167748 666: 640: 614: 560: 529: 520: 515: 511: 507: 503: 499: 495: 491: 487: 483: 469: 458: 453: 449: 445: 441: 437: 435:skin of abdomen 433: 429: 425: 421: 407: 351: 338: 330: 320: 319: 318: 311: 291: 268:Gene location ( 250: 237: 229: 219: 218: 217: 210: 188: 165:Gene location ( 116: 103: 96: 73: 51: 17: 12: 11: 5: 2557: 2555: 2547: 2546: 2541: 2536: 2531: 2521: 2520: 2515: 2514: 2507: 2500: 2492: 2489: 2488: 2467: 2453: 2452: 2450: 2449: 2448: 2447: 2442: 2432: 2427: 2418: 2404: 2399: 2394: 2393: 2392: 2387: 2377: 2372: 2367: 2361: 2359: 2355: 2354: 2352: 2351: 2346: 2340: 2338: 2332: 2331: 2329: 2328: 2323: 2318: 2313: 2307: 2305: 2298: 2297: 2295: 2294: 2289: 2288: 2287: 2282: 2272: 2267: 2262: 2256: 2254: 2248: 2247: 2245: 2244: 2243: 2242: 2237: 2227: 2215: 2214: 2213: 2212: 2207: 2202: 2197: 2192: 2187: 2182: 2177: 2172: 2167: 2162: 2157: 2152: 2147: 2142: 2137: 2127: 2122: 2117: 2112: 2107: 2102: 2093: 2091: 2085: 2084: 2082: 2081: 2080: 2079: 2074: 2064: 2059: 2054: 2048: 2046: 2040: 2039: 2024:Endopeptidases 2022: 2020: 2019: 2012: 2005: 1997: 1988: 1987: 1985: 1984: 1978: 1971: 1968: 1965: 1964: 1961: 1959: 1958: 1951: 1944: 1936: 1930: 1929: 1917: 1916:External links 1914: 1912: 1911: 1882: 1847: 1818: 1789: 1779:(8): 1855–63. 1768: 1725: 1682: 1653: 1624: 1603: 1574: 1545: 1502: 1473: 1444: 1412:Int. J. Cancer 1407: 1378: 1357: 1312: 1310: 1307: 1304: 1303: 1289: 1262:(6): 635–824. 1246: 1195: 1159: 1141: 1123: 1102: 1080: 1079: 1077: 1074: 1073: 1072: 1067: 1060: 1057: 1017: 1016: 1013: 1012: 1007: 997: 996: 990: 989: 986: 985: 983: 981: 974: 973: 966: 959: 955: 954: 951: 950: 932: 931: 925: 922: 921: 911: 910: 904: 900: 899: 896: 895: 877: 876: 870: 867: 866: 856: 855: 849: 845: 844: 841: 840: 832: 831: 825: 822: 821: 813: 812: 806: 800: 799: 796: 795: 787: 786: 780: 777: 776: 768: 767: 761: 755: 754: 751: 750: 742: 741: 735: 732: 731: 723: 722: 716: 710: 709: 704: 699: 695: 694: 684: 683: 680: 679: 668: 667: 665: 664: 659: 654: 648: 646: 642: 641: 639: 638: 633: 628: 622: 620: 616: 615: 613: 612: 607: 602: 597: 591: 589: 585: 584: 574: 573: 570: 569: 566: 565: 557: 556: 545: 539: 538: 535: 534: 526: 525: 522: 521: 519: 518: 514: 510: 506: 505:lacrimal gland 502: 501:pyloric antrum 498: 494: 490: 486: 482: 478: 475: 474: 463: 460: 459: 457: 456: 452: 448: 444: 440: 436: 432: 428: 424: 420: 416: 413: 412: 400: 399: 391: 380: 374: 373: 370:RNA expression 362: 361: 358: 357: 349: 345: 344: 336: 333: 328: 322: 321: 312: 305: 299: 295: 294: 289: 283: 282: 274: 273: 261: 260: 257: 256: 248: 244: 243: 235: 232: 227: 221: 220: 211: 204: 198: 194: 193: 186: 180: 179: 171: 170: 158: 157: 114: 110: 109: 101: 93: 92: 88: 87: 84: 83: 80: 79: 69: 68: 60: 59: 48: 42: 41: 33: 32: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 2556: 2545: 2542: 2540: 2537: 2535: 2532: 2530: 2527: 2526: 2524: 2513: 2508: 2506: 2501: 2499: 2494: 2493: 2487: 2485: 2481: 2477: 2476:chromosome 19 2473: 2468: 2465: 2461: 2446: 2443: 2441: 2438: 2437: 2436: 2433: 2431: 2430:Streptokinase 2428: 2426: 2422: 2419: 2416: 2412: 2408: 2405: 2403: 2400: 2398: 2395: 2391: 2388: 2386: 2383: 2382: 2381: 2378: 2376: 2373: 2371: 2368: 2366: 2363: 2362: 2360: 2356: 2350: 2347: 2345: 2342: 2341: 2339: 2337: 2333: 2327: 2324: 2322: 2319: 2317: 2314: 2312: 2309: 2308: 2306: 2304: 2303:immune system 2299: 2293: 2292:C3-convertase 2290: 2286: 2283: 2281: 2278: 2277: 2276: 2273: 2271: 2268: 2266: 2263: 2261: 2258: 2257: 2255: 2253: 2249: 2241: 2238: 2236: 2233: 2232: 2231: 2228: 2226: 2223: 2221: 2217: 2216: 2211: 2208: 2206: 2203: 2201: 2198: 2196: 2193: 2191: 2188: 2186: 2183: 2181: 2178: 2176: 2173: 2171: 2168: 2166: 2163: 2161: 2158: 2156: 2153: 2151: 2148: 2146: 2143: 2141: 2138: 2136: 2133: 2132: 2131: 2128: 2126: 2123: 2121: 2118: 2116: 2113: 2111: 2108: 2106: 2103: 2101: 2098: 2095: 2094: 2092: 2090: 2086: 2078: 2075: 2073: 2070: 2069: 2068: 2065: 2063: 2060: 2058: 2055: 2053: 2050: 2049: 2047: 2045: 2041: 2036: 2033: 2029: 2025: 2018: 2013: 2011: 2006: 2004: 1999: 1998: 1995: 1981: 1975: 1970: 1966: 1957: 1952: 1950: 1945: 1943: 1938: 1937: 1934: 1928: 1924: 1920: 1919: 1915: 1908: 1904: 1900: 1896: 1892: 1888: 1883: 1879: 1875: 1870: 1865: 1861: 1857: 1856:J. Biol. Chem 1853: 1848: 1844: 1840: 1836: 1832: 1829:(6): 757–61. 1828: 1824: 1819: 1815: 1811: 1807: 1803: 1799: 1795: 1790: 1786: 1782: 1778: 1774: 1769: 1765: 1761: 1756: 1751: 1747: 1743: 1739: 1735: 1731: 1726: 1722: 1718: 1713: 1708: 1704: 1700: 1696: 1692: 1688: 1683: 1679: 1675: 1671: 1667: 1664:(6): 445–50. 1663: 1659: 1654: 1650: 1646: 1642: 1638: 1635:(3): 989–92. 1634: 1630: 1625: 1621: 1617: 1614:(3): 177–82. 1613: 1609: 1604: 1600: 1596: 1592: 1588: 1584: 1580: 1575: 1571: 1567: 1563: 1559: 1556:(9): 3124–9. 1555: 1551: 1546: 1542: 1538: 1533: 1528: 1524: 1520: 1517:(3): 787–93. 1516: 1512: 1508: 1503: 1499: 1495: 1491: 1487: 1484:(4): 237–49. 1483: 1479: 1474: 1470: 1466: 1462: 1458: 1454: 1450: 1445: 1441: 1437: 1433: 1429: 1425: 1421: 1418:(4): 654–60. 1417: 1413: 1408: 1404: 1400: 1396: 1392: 1388: 1384: 1379: 1375: 1371: 1367: 1363: 1358: 1354: 1350: 1346: 1342: 1338: 1334: 1330: 1326: 1319: 1314: 1313: 1308: 1299: 1293: 1290: 1285: 1281: 1277: 1273: 1269: 1265: 1261: 1257: 1250: 1247: 1242: 1238: 1234: 1230: 1226: 1222: 1219:(6): 637–41. 1218: 1214: 1207: 1199: 1196: 1191: 1187: 1183: 1179: 1175: 1171: 1163: 1160: 1155: 1151: 1145: 1142: 1137: 1133: 1127: 1124: 1120: 1116: 1111: 1109: 1107: 1103: 1099: 1095: 1090: 1088: 1086: 1082: 1075: 1071: 1068: 1066: 1063: 1062: 1058: 1056: 1054: 1050: 1045: 1040: 1038: 1034: 1031: 1027: 1023: 1011: 1006: 1002: 998: 995: 991: 984: 982: 979: 975: 971: 967: 964: 960: 956: 949: 947: 943: 939: 933: 929: 926: 920: 918: 912: 908: 905: 901: 894: 892: 888: 884: 878: 874: 871: 865: 863: 857: 853: 850: 848:RefSeq (mRNA) 846: 839: 838: 833: 829: 826: 820: 819: 814: 810: 807: 805: 801: 794: 793: 788: 784: 781: 775: 774: 769: 765: 762: 760: 756: 749: 748: 743: 739: 736: 730: 729: 724: 720: 717: 715: 711: 708: 705: 703: 700: 696: 693: 689: 685: 678: 674: 669: 663: 660: 658: 655: 653: 650: 649: 647: 644: 643: 637: 634: 632: 629: 627: 624: 623: 621: 618: 617: 611: 608: 606: 603: 601: 598: 596: 593: 592: 590: 587: 586: 583: 582:Gene ontology 579: 575: 563: 558: 554: 549: 546: 544: 540: 532: 527: 516: 512: 508: 504: 500: 496: 492: 488: 485:parotid gland 484: 480: 479: 476: 472: 467: 464: 454: 450: 446: 442: 438: 434: 430: 427:parotid gland 426: 422: 418: 417: 414: 410: 405: 402: 401: 398: 396: 392: 390: 389: 385: 384: 381: 379: 375: 371: 367: 363: 355: 350: 346: 342: 337: 327: 323: 316: 309: 303: 296: 288: 284: 280: 275: 271: 266: 262: 254: 249: 245: 241: 236: 226: 222: 215: 208: 202: 195: 191: 185: 181: 177: 172: 168: 163: 159: 155: 151: 147: 143: 139: 135: 131: 127: 123: 119: 111: 106: 99: 94: 89: 78: 76: 70: 65: 62: 61: 57: 54: 47: 43: 38: 34: 30: 25: 20: 2484:expanding it 2469: 2220:fibrinolysis 2218: 2139: 2096: 2062:Chymotrypsin 1979: 1890: 1886: 1859: 1855: 1826: 1822: 1800:(3): 325–8. 1797: 1793: 1776: 1772: 1740:(2): 481–6. 1737: 1733: 1697:(1): 233–8. 1694: 1690: 1661: 1657: 1632: 1628: 1611: 1607: 1582: 1579:Biochemistry 1578: 1553: 1550:Biochemistry 1549: 1514: 1510: 1481: 1477: 1455:(4): 222–6. 1452: 1448: 1415: 1411: 1386: 1382: 1365: 1361: 1328: 1324: 1292: 1259: 1255: 1249: 1216: 1212: 1198: 1176:(1): 77–82. 1173: 1169: 1162: 1153: 1144: 1135: 1126: 1041: 1029: 1022:Kallikrein-1 1021: 1020: 942:NP_001307261 938:NP_001307260 935: 914: 891:NM_001320332 887:NM_001320331 880: 859: 835: 816: 790: 771: 745: 726: 706: 701: 497:human kidney 489:right kidney 393: 386: 113:External IDs 72: 2125:Factor XIIa 2105:Factor VIIa 2089:Coagulation 1962:PDB gallery 1389:(1): 6–11. 1331:(1): 5–14. 1070:Kininogen 1 652:proteolysis 451:skin of arm 443:skin of leg 352:43,879,042 339:43,874,784 251:50,823,787 238:50,819,146 91:Identifiers 2523:Categories 2407:Subtilisin 2349:Batroxobin 2130:Kallikrein 2120:Factor XIa 2110:Factor IXa 2077:Pancreatic 2072:Neutrophil 1734:Biochem. J 1691:Biochem. J 1629:J. Biochem 1511:Biochem. J 1449:Hum. Hered 1325:Biol. Chem 1121:, May 2017 1100:, May 2017 1076:References 1049:bradykinin 493:left colon 397:(ortholog) 134:HomoloGene 2539:EC 3.1.21 2534:Proteases 2474:on human 2435:Cathepsin 2421:Sedolisin 2397:Prostasin 2115:Factor Xa 1256:Biol Chem 1213:Biol Chem 946:NP_034769 917:NP_002248 883:NM_010639 862:NM_002257 692:Orthologs 447:beta cell 142:GeneCards 2336:Venombin 2321:Tryptase 2316:Granzyme 2270:Factor I 2265:Factor D 2260:Factor B 2100:Thrombin 2097:factors: 2067:Elastase 1907:10862973 1440:33875411 1383:Genomics 1345:11258672 1284:83910246 1276:16800723 1233:16800724 1170:Genomics 1117:– 1096:– 1059:See also 994:Wikidata 671:Sources: 513:duodenum 230:19q13.33 2375:Pronase 2365:Acrosin 2311:Chymase 2225:Plasmin 2057:Trypsin 1927:S01.160 1878:9368023 1843:9276160 1814:7916636 1785:7749374 1764:7733886 1755:1136673 1721:7492318 1712:1136249 1678:3853975 1649:3635530 1620:3163150 1599:3004571 1570:2898948 1541:2686621 1532:1133342 1498:2666327 1469:1783409 1432:1691151 1403:1385301 1353:5864448 1190:1684954 1119:Ensembl 1098:Ensembl 1051:, from 1026:protein 804:UniProt 759:Ensembl 698:Species 677:QuickGO 631:nucleus 372:pattern 98:Aliases 2402:Reelin 2344:Ancrod 2301:Other 2035:3.4.21 1923:MEROPS 1905:  1876:  1841:  1812:  1783:  1762:  1752:  1719:  1709:  1676:  1647:  1618:  1597:  1568:  1539:  1529:  1496:  1467:  1438:  1430:  1401:  1374:393608 1372:  1351:  1343:  1282:  1274:  1241:436200 1239:  1231:  1188:  1044:serine 980:search 978:PubMed 837:P15947 818:P06870 714:Entrez 543:BioGPS 431:rectum 138:110727 130:102850 122:147910 2478:is a 2411:Furin 2358:Other 2285:MASP2 2280:MASP1 2210:KLK15 2205:KLK14 2200:KLK13 2195:KLK12 2190:KLK11 2185:KLK10 1436:S2CID 1349:S2CID 1321:(PDF) 1280:S2CID 1237:S2CID 1209:(PDF) 1024:is a 747:16612 707:Mouse 702:Human 673:Amigo 455:gonad 395:Mouse 388:Human 335:Start 270:Mouse 234:Start 167:Human 2480:stub 2472:gene 2425:TPP1 2275:MASP 2180:KLK9 2175:KLK8 2170:KLK7 2165:KLK6 2160:KLK5 2155:KLK4 2150:KLK3 2145:KLK2 2140:KLK1 1980:1spj 1921:The 1903:PMID 1891:1479 1874:PMID 1839:PMID 1810:PMID 1798:1173 1781:PMID 1760:PMID 1717:PMID 1674:PMID 1645:PMID 1616:PMID 1595:PMID 1566:PMID 1537:PMID 1494:PMID 1465:PMID 1428:PMID 1399:PMID 1370:PMID 1341:PMID 1272:PMID 1229:PMID 1186:PMID 1033:gene 1030:KLK1 728:3816 378:Bgee 326:Band 287:Chr. 225:Band 184:Chr. 146:KLK1 118:OMIM 105:KLK1 75:1SPJ 56:RCSB 53:PDBe 22:KLK1 2415:S1P 2135:PSA 1895:doi 1864:doi 1860:272 1831:doi 1802:doi 1750:PMC 1742:doi 1738:307 1707:PMC 1699:doi 1695:312 1666:doi 1658:DNA 1637:doi 1587:doi 1558:doi 1527:PMC 1519:doi 1515:262 1486:doi 1457:doi 1420:doi 1391:doi 1366:360 1333:doi 1329:382 1264:doi 1260:387 1221:doi 1217:387 1178:doi 348:End 247:End 150:OMA 126:MGI 46:PDB 2525:: 2032:EC 2026:: 1901:. 1889:. 1872:. 1858:. 1854:. 1837:. 1827:75 1825:. 1808:. 1796:. 1777:27 1775:. 1758:. 1748:. 1736:. 1732:. 1715:. 1705:. 1693:. 1689:. 1672:. 1660:. 1643:. 1633:99 1631:. 1610:. 1593:. 1583:24 1581:. 1564:. 1554:27 1552:. 1535:. 1525:. 1513:. 1509:. 1492:. 1482:33 1480:. 1463:. 1453:41 1451:. 1434:. 1426:. 1416:45 1414:. 1397:. 1387:14 1385:. 1364:. 1347:. 1339:. 1327:. 1323:. 1278:. 1270:. 1258:. 1235:. 1227:. 1215:. 1211:. 1184:. 1174:11 1172:. 1152:. 1134:. 1105:^ 1084:^ 1055:. 1039:. 675:/ 354:bp 341:bp 253:bp 240:bp 148:; 144:: 140:; 136:: 132:; 128:: 124:; 120:: 2511:e 2504:t 2497:v 2486:. 2445:G 2440:A 2423:/ 2417:4 2413:/ 2409:/ 2390:2 2385:1 2222:: 2037:) 2030:( 2016:e 2009:t 2002:v 1955:e 1948:t 1941:v 1909:. 1897:: 1880:. 1866:: 1845:. 1833:: 1816:. 1804:: 1787:. 1766:. 1744:: 1723:. 1701:: 1680:. 1668:: 1662:4 1651:. 1639:: 1622:. 1612:1 1601:. 1589:: 1572:. 1560:: 1543:. 1521:: 1500:. 1488:: 1471:. 1459:: 1442:. 1422:: 1405:. 1393:: 1376:. 1355:. 1335:: 1300:. 1286:. 1266:: 1243:. 1223:: 1192:. 1180:: 1156:. 1138:. 272:) 169:) 152::

Index


PDB
PDBe
RCSB
1SPJ
Aliases
KLK1
OMIM
147910
MGI
102850
HomoloGene
110727
GeneCards
KLK1
OMA
KLK1 - orthologs
Human
Chromosome 19 (human)
Chr.
Chromosome 19 (human)
Chromosome 19 (human)
Genomic location for KLK1
Genomic location for KLK1
Band
bp
bp
Mouse
Chromosome 7 (mouse)
Chr.

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