141:
118:
351:
344:
147:
1705:
1269:
Chang A, Yousef GM, Jung K, et al. (2002). "Identification and molecular characterization of five novel kallikrein gene 13 (KLK13; KLK-L4) splice variants: differential expression in the human testis and testicular cancer".
974:
Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006).
1457:
Petraki CD, Gregorakis AK, Papanastasiou PA, et al. (2004). "Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues".
154:
1085:
Milewska A, Falkowski K, Kulczycka M, Bielecka E, Naskalska A, Mak P, Lesner A, Ochman M, Urlik M, Diamandis E, Prassas I, Potempa J, Kantyka T, Pyrc K (2020).
1025:
Diamandis EP, Deperthes D, Lundwall Å (Jun 2006). "Proceedings of the 1st
International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005".
559:
1240:
Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region".
855:
As of 2022, the precise physiological functions of
Kallikrein 13 remain unknown. It may play a role in the defense of the upper digestive apparatus, in
540:
79:
1774:
1750:
956:
1211:
Yousef GM, Chang A, Scorilas A, Diamandis EP (2000). "Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4".
938:
1293:"Human kallikrein gene 13 (KLK13) expression by quantitative RT-PCR: an independent indicator of favourable prognosis in breast cancer"
140:
1178:"Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues"
1494:
Kapadia C, Yousef GM, Mellati AA, et al. (2004). "Complex formation between human kallikrein 13 and serum protease inhibitors".
774:
117:
1071:
925:
1139:
Diamandis EP, Yousef GM, Luo LY, et al. (2001). "The new human kallikrein gene family: implications in carcinogenesis".
921:
1566:
Kapadia C, Ghosh MC, Grass L, Diamandis EP (2004). "Human kallikrein 13 involvement in extracellular matrix degradation".
153:
59:
146:
1743:
602:
67:
1597:"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"
890:
1736:
1769:
1536:
1347:
883:
856:
46:
733:
729:
699:
1669:
1482:
1164:
1050:
1007:
91:
1336:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
725:
678:
1661:
1626:
1583:
1554:
1511:
1474:
1445:
1410:
1375:
1322:
1279:
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1199:
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1116:
1042:
999:
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350:
39:
1720:
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1616:
1608:
1575:
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1503:
1466:
1435:
1400:
1365:
1355:
1312:
1304:
1249:
1220:
1189:
1148:
1106:
1098:
1034:
991:
233:
164:
108:
1693:
1087:"Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1"
343:
87:
1424:"Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages"
976:
875:
849:
208:
1540:
1351:
1317:
1292:
1111:
1086:
977:"A comprehensive nomenclature for serine proteases with homology to tissue kallikreins"
897:
1621:
1596:
1370:
1335:
1253:
1152:
474:
469:
464:
448:
443:
438:
433:
417:
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407:
402:
397:
392:
1763:
1716:
1440:
1423:
879:
871:
379:
1486:
1168:
1054:
71:
1673:
226:
1011:
1389:"Human kallikrein 13 expression in normal tissues: an immunohistochemical study"
961:
National Center for
Biotechnology Information, U.S. National Library of Medicine
943:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1656:
1639:
1579:
1507:
1405:
1388:
266:
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867:
125:
75:
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83:
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1587:
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1414:
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1326:
1308:
1283:
1261:
1232:
1224:
1203:
1160:
1120:
1046:
1003:
886:
has been identified, but its full length sequence has not been determined.
814:
809:
798:
636:
632:
628:
1549:
1524:
1038:
995:
1612:
830:
614:
571:
900:
and some have potential as novel cancer and other disease biomarkers.
1689:
782:
526:
95:
1704:
889:
Kallikrein-13 serves as a priming protease during infection by the
489:
485:
1712:
837:
359:
63:
1638:
Darling MR, Jackson-Boeters L, Daley TD, Diamandis EP (2006).
1334:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1640:"Human kallikrein 13 expression in salivary gland tumors"
216:
1724:
1595:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
1692:
online database for peptidases and their inhibitors:
1525:"The DNA sequence and biology of human chromosome 19"
333:
1523:
Grimwood J, Gordon LA, Olsen A, et al. (2004).
1291:
Chang A, Yousef GM, Scorilas A, et al. (2002).
1072:"Entrez Gene: KLK13 kallikrein-related peptidase 13"
1422:Komatsu N, Takata M, Otsuki N, et al. (2003).
747:
718:
692:
671:
917:
915:
913:
163:
50:, KLK-L4, KLKL4, kallikrein related peptidase 13
1387:Petraki CD, Karavana VN, Diamandis EP (2003).
922:GRCm38: Ensembl release 89: ENSMUSG00000054046
1744:
8:
1751:
1737:
874:. Expression of this gene is regulated by
500:
375:
204:
103:
1655:
1620:
1548:
1439:
1404:
1369:
1359:
1316:
1193:
1176:Yousef GM, Chang A, Diamandis EP (2000).
1110:
852:having diverse physiological functions.
1066:
1064:
909:
863:, and in the male reproductive organs.
20:
168:
129:
124:
7:
1701:
1699:
896:Many kallikreins are implicated in
1723:. You can help Knowledge (XXG) by
878:and may be useful as a marker for
744:
715:
689:
668:
646:
619:
593:
576:
550:
531:
408:serine-type endopeptidase activity
338:
261:
242:
221:
14:
833:that in humans is encoded by the
1703:
1441:10.1046/j.1523-1747.2003.12363.x
870:members located in a cluster on
866:This gene is one of the fifteen
349:
342:
152:
145:
139:
116:
18:Gene of the species Homo sapiens
1775:Human chromosome 19 gene stubs
848:Kallikreins are a subgroup of
398:serine-type peptidase activity
360:More reference expression data
1:
1568:Biochem. Biophys. Res. Commun
1459:Prostate Cancer Prostatic Dis
1254:10.1016/S0378-1119(00)00382-6
1213:Biochem. Biophys. Res. Commun
1153:10.1016/S1043-2760(99)00225-8
137:
1340:Proc. Natl. Acad. Sci. U.S.A
1791:
1698:
1657:10.1177/172460080602100206
1580:10.1016/j.bbrc.2004.08.206
1508:10.1016/j.cccn.2003.10.009
1406:10.1177/002215540305100411
1103:10.1126/scisignal.aba9902
957:"Mouse PubMed Reference:"
939:"Human PubMed Reference:"
813:
808:
804:
797:
781:
764:
751:
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675:
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626:
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583:
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186:
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136:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
1195:10.1074/jbc.275.16.11891
1141:Trends Endocrinol. Metab
1471:10.1038/sj.pcan.4500674
775:Chr 7: 43.36 – 43.38 Mb
1393:J. Histochem. Cytochem
1361:10.1073/pnas.242603899
1309:10.1038/sj.bjc.6600283
1225:10.1006/bbrc.2000.3448
891:human coronavirus HKU1
403:endopeptidase activity
1644:Int. J. Biol. Markers
868:kallikrein subfamily
857:extracellular matrix
439:extracellular region
131:Chromosome 7 (mouse)
1550:10.1038/nature02399
1541:2004Natur.428..529G
1428:J. Invest. Dermatol
1352:2002PNAS...9916899M
1039:10.1515/BC.2006.081
996:10.1515/BC.2006.082
444:extracellular space
1711:This article on a
1613:10.1101/gr.2596504
884:transcript variant
861:tissue remodelling
603:ENSMUSG00000054046
475:protein processing
458:Biological process
427:Cellular component
418:hydrolase activity
393:peptidase activity
386:Molecular function
1732:
1731:
1346:(26): 16899–903.
1097:(659): eaba9902.
1091:Science Signaling
824:
823:
820:
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449:secretory granule
370:
369:
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365:
328:
327:
320:
319:
258:
257:
199:
198:
96:KLK13 - orthologs
1782:
1753:
1746:
1739:
1707:
1700:
1677:
1659:
1634:
1624:
1591:
1562:
1552:
1535:(6982): 529–35.
1519:
1496:Clin. Chim. Acta
1490:
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1408:
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1016:
1015:
981:
971:
965:
964:
953:
947:
946:
935:
929:
919:
882:. An additional
876:steroid hormones
859:degradation, in
850:serine proteases
806:
805:
777:
770:
755:
745:
736:
716:
712:RefSeq (protein)
702:
690:
681:
669:
647:
620:
594:
577:
551:
532:
501:
376:
362:
353:
346:
339:
269:
267:Top expressed in
262:
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182:
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49:
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1758:
1757:
1685:
1680:
1637:
1607:(10B): 2121–7.
1594:
1565:
1522:
1502:(1–2): 157–67.
1493:
1456:
1421:
1386:
1333:
1290:
1268:
1239:
1210:
1188:(16): 11891–8.
1175:
1138:
1134:
1132:Further reading
1129:
1128:
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1083:
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815:View/Edit Mouse
810:View/Edit Human
773:
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765:Location (UCSC)
753:
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728:
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413:protein binding
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107:Gene location (
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1683:External links
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1679:
1678:
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1592:
1574:(3): 1084–90.
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1520:
1491:
1454:
1419:
1399:(4): 493–501.
1384:
1331:
1303:(9): 1457–64.
1288:
1278:(5): 3147–52.
1272:Anticancer Res
1266:
1237:
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1127:
1126:
1077:
1060:
1033:(6): 635–824.
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898:carcinogenesis
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1717:chromosome 19
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1691:
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1675:
1671:
1667:
1663:
1658:
1653:
1650:(2): 106–10.
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1407:
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1314:
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1306:
1302:
1298:
1297:Br. J. Cancer
1294:
1289:
1285:
1281:
1277:
1273:
1267:
1263:
1259:
1255:
1251:
1248:(1): 119–30.
1247:
1243:
1238:
1234:
1230:
1226:
1222:
1219:(1): 125–33.
1218:
1214:
1209:
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1191:
1187:
1183:
1182:J. Biol. Chem
1179:
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1036:
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1028:
1021:
1018:
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1009:
1005:
1001:
997:
993:
990:(6): 637–41.
989:
985:
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952:
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944:
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934:
931:
927:
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881:
880:breast cancer
877:
873:
872:chromosome 19
869:
864:
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858:
853:
851:
843:
841:
839:
836:
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828:
827:Kallikrein-13
816:
811:
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789:
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721:
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674:
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665:RefSeq (mRNA)
663:
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621:
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465:cornification
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380:Gene ontology
377:
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337:
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323:
312:
308:
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297:hair follicle
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85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
16:
1725:expanding it
1710:
1647:
1643:
1604:
1600:
1571:
1567:
1532:
1528:
1499:
1495:
1465:(3): 223–7.
1462:
1458:
1434:(3): 542–9.
1431:
1427:
1396:
1392:
1343:
1339:
1300:
1296:
1275:
1271:
1245:
1241:
1216:
1212:
1185:
1181:
1147:(2): 54–60.
1144:
1140:
1094:
1090:
1080:
1030:
1026:
1020:
987:
983:
969:
960:
951:
942:
933:
895:
888:
865:
854:
847:
834:
826:
825:
752:
734:NP_001335107
730:NP_001335106
723:
700:NM_001039042
697:
676:
654:
627:
601:
584:
558:
539:
519:
514:
232:
225:
55:External IDs
15:
1770:Human genes
470:proteolysis
191:43,376,958
178:43,361,991
170:7|7 B3
33:Identifiers
1764:Categories
1601:Genome Res
928:, May 2017
904:References
236:(ortholog)
76:HomoloGene
24:KLK13kmpll
1715:on human
1027:Biol Chem
984:Biol Chem
726:NP_056411
679:NM_015596
505:Orthologs
434:cytoplasm
277:esophagus
84:GeneCards
1666:16847813
1631:15489334
1588:15381110
1559:15057824
1516:14687906
1487:21609011
1479:12970725
1450:12925213
1415:12642628
1380:12477932
1327:11986781
1284:11848466
1262:11054574
1233:11006094
1204:10766816
1169:25806934
1161:10675891
1121:33234691
1055:83910246
1047:16800723
1004:16800724
924:–
844:Function
799:Wikidata
484:Sources:
1694:S01.306
1674:7038149
1537:Bibcode
1348:Bibcode
1318:2375362
1112:7857416
926:Ensembl
831:protein
615:UniProt
572:Ensembl
511:Species
490:QuickGO
305:stomach
211:pattern
72:3615275
40:Aliases
1690:MEROPS
1672:
1664:
1629:
1622:528928
1619:
1586:
1557:
1529:Nature
1514:
1485:
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1448:
1413:
1378:
1371:139241
1368:
1325:
1315:
1282:
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1231:
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1167:
1159:
1119:
1109:
1053:
1045:
1012:436200
1010:
1002:
785:search
783:PubMed
637:Q5BQ97
633:Q5BQ95
629:Q9UKR3
560:626834
527:Entrez
334:BioGPS
313:oocyte
301:zygote
289:embryo
285:embryo
64:605505
1719:is a
1670:S2CID
1483:S2CID
1165:S2CID
1051:S2CID
1008:S2CID
980:(PDF)
835:KLK13
829:is a
541:26085
520:Mouse
515:Human
486:Amigo
234:Mouse
227:Human
174:Start
109:Mouse
88:KLK13
80:56714
47:KLK13
1721:stub
1713:gene
1688:The
1662:PMID
1627:PMID
1584:PMID
1555:PMID
1512:PMID
1475:PMID
1446:PMID
1411:PMID
1376:PMID
1323:PMID
1280:PMID
1258:PMID
1242:Gene
1229:PMID
1200:PMID
1157:PMID
1117:PMID
1043:PMID
1000:PMID
838:gene
217:Bgee
165:Band
126:Chr.
60:OMIM
1652:doi
1617:PMC
1609:doi
1576:doi
1572:323
1545:doi
1533:428
1504:doi
1500:339
1467:doi
1436:doi
1432:121
1401:doi
1366:PMC
1356:doi
1313:PMC
1305:doi
1250:doi
1246:257
1221:doi
1217:276
1190:doi
1186:275
1149:doi
1107:PMC
1099:doi
1035:doi
1031:387
992:doi
988:387
769:n/a
754:n/a
655:n/a
585:n/a
281:lip
252:n/a
187:End
92:OMA
68:MGI
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