329:
306:
203:
228:
1534:
hexameric complex structure and initiate signaling cascades. In both mice and humans, this signalling depends on the association between NKG2D and DAP10 protein forming a complex. Upon ligand engagement, Tyr-X-X-Meth (YXXM) motif within the cytoplasmic domain of DAP10 recruits PI3K and Grb2 to activate NK cell cytotoxicity pathways. In mice, NKG2D associates with DAP 12, instead of DAP 10, and NKG2D-DAP12 complex is involved in IFN-γ production through the Syk and ZAP70 pathway.
335:
234:
40:
1567:(IL-15R) is a crucial factor for development, homeostasis and survival of NK cells and NKG2D signaling seems to be similarly critical. Connection between these two pathways is the binding of DAP10, adaptor protein and signal transducer, which associates with IL-15R or NKG2D, respectively. This phenomenon was proven by experiments on mice knocked out in
1518:, cells upregulate the expression of NKG2D ligands that enable NK-mediated killing of senescent cells via the granule exocytosis pathway. Specifically, MICA and ULBP2 proteins on senescent cells are recognized by the NKG2D receptor on Natural Killer cells, which is necessary for efficient recognition and elimination of senescent cells.
1608:
the low level of mTORC1 and for terminally differentiated CD8 T cells, high level of mTORC1 activity is typical. Upregulation of antiapoptic Mcl-1 protein by NKG2D also induces formation of memory T cells. In murine memory T cell precursors, downregulation of T-bet transcription factor is likewise affected by NKG2D.
1556:, mainly involved in the early cytolytic defense against infections and tumors. NK cell activity is mediated by a variety of cell surface receptors with stimulatory and inhibitory activity. Under normal conditions, NK cells exist in an inactive state, with signaling dominated by inhibitory receptor activation.
1297:
which are completely absent or present only at low levels on surface of normal cells, but they are overexpressed by infected, transformed, senescent and stressed cells. Their expression is regulated at different stages (transcription, mRNA and protein stabilization, cleavage from the cell surface) by
1599:
are all necessary components. Co-stimulation regulates responsiveness of T cells and NKG2D is one of well-documented co-stimulatory molecules for T cells., CD28 –mediated co-stimulation is required for promotion of cytokine production and cytotoxicity in CD8 T cells by NKG2D. For cytokine production
1500:
As cancerous cells are "stressed", NKG2D ligands become upregulated, rendering the cell susceptible to NK cell-mediated lysis. However, some tumor cells have acquired the capacity to evade this immune surveillance. They have created the capacity of reducing and eliminating the high volume of NKG2DL
1607:
In T cells, NKG2D is associated with IL15-receptor signaling and also with the development of memory CD8 T cells. Key role in the transformation of CD8 T cells into effector or memory types is played by mammalian target of rapamycin complex 1 (mTORC1) – memory precursor cells are characteristic by
1574:
NKG2D is involved in the generation of peripheral tolerance by the effective downregulation of NKG2D ligands, for the prevention from recognition by NK cells. It is supposed to act as a form of obstacle against NK cells' hyper-responsiveness to ligands, without complete education in bone marrow.
1450:
genes ). One of the major signals for cell expression of NKG2D is the triggering of DDR along with the induction of senescence program. RNA splicing is another mechanism influencing NKG2D ligand expression. For MICA, ULBP4 and ULBP5, alternative splicing isoforms have been shown. However, the
1533:
When NKG2D receptor binds to any of its ligands, an activation cascade starts for activating the respective immune cell. NKG2D does not possess any signaling elements within its intracellular domain. NKG2D forms a homodimer and associates with adaptor proteins in its transmembrane domain to a
1559:
NKG2G is a key stimulatory cell surface receptor. A low expression of the receptor is observed already in the early NK cells precursor stages, also the concentration of receptors is increased with maturation of NK cells. In mice, both NKG2D isoforms were detected. During resting state,
1541:. This pathway activation depend on two main basis. The first is the plasticity and structural changes of NKG2D (receptor) when binding to its ligands. The last one is the association of DAP10 in the intracellular domain of the receptor and the recruitment of PI3K and Grb.
66:
1505:
that cleave these ligands, and therefore they escape from the control of NK cells and their cytotoxic activity. TGF-β allows immune surveillance escape by inhibiting T and NK cell function. Tumor cells that can evade NKG2D responses are thus more likely to propagate.
1298:
various stress pathways. Among them, one of the most prominent stress pathways is DNA damage response. Genotoxic stress, stalled DNA replication, poorly regulated cell proliferation in tumorigenesis, viral replication or some viral products activate the
1455:
protein, which mediates RNA degradation, constitutively targets mRNA of NKG2D ligands. Additionally, surface expression levels of NKG2D can be controlled by soluble forms of various protease-mediated cleavages and exosome expression.
1410:, posttranscriptional and posttranslational. On the transcriptional level, NKG2D ligands can be regulated by transcription factors or regulatory sequences in various molecular pathways. Also, the regulation of NKG2D ligands after
1306:
kinases. These kinases initiate the DNA damage response pathway which participates in NKG2D ligand upregulation. DNA damage response thus participate in alerting the immune system to the presence of potentially dangerous cells.
2092:
Upshaw JL, Arneson LN, Schoon RA, Dick CJ, Billadeau DD, Leibson PJ (May 2006). "NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells".
1575:
Tolerance of NK cells is likewise observed during pregnancy, when placenta produces soluble and exosome-bound ligands for NKG2D and accumulates large number of NK cells which prevent recognition of fetus as non-self.
1616:
Also development of B cells is regulated by NKG2D—NKG2D deficient mice have reduced number of B cells in spleen, which is partially depended on DAP10. In comparison to NK cells, mature B cells do not express NKG2D.
1217:
dimer. This association is maintained by ionic interaction of a positively charged arginine present in a transmembrane segment of NKG2D and negatively charged aspartic acids within both transmembrane regions of
1571:– such mice have higher proliferation rate, faster differentiation and maturation of NK cells, resulting in a misbalance of immature NK cell subpopulations and higher susceptibility to apoptosis of NK cells.
2136:
Diefenbach A, Tomasello E, Lucas M, Jamieson AM, Hsia JK, Vivier E, Raulet DH (December 2002). "Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D".
1472:. In NK cells, NKG2D serves as an activating receptor, which itself is able to trigger cytotoxicity. The function of NKG2D on CD8 T cells is to send co-stimulatory signals to activate them.
3424:
Groh V, Rhinehart R, Randolph-Habecker J, Topp MS, Riddell SR, Spies T (March 2001). "Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells".
2943:
Serrano AE, Menares-Castillo E, Garrido-Tapia M, Ribeiro CH, Hernández CJ, Mendoza-Naranjo A, et al. (March 2011). "Interleukin 10 decreases MICA expression on melanoma cell surface".
4672:
3510:"NKG2D costimulates human V gamma 9V delta 2 T cell antitumor cytotoxicity through protein kinase C theta-dependent modulation of early TCR-induced calcium and transduction signals"
1213:
Human NKG2D receptor complex assembles into a hexameric structure. NKG2D itself forms a homodimer whose ectodomains serve for ligand binding. Each NKG2D monomer is associated with
1464:
NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells as its ligands are induced during cellular stress, either as a result of
1169:(killer cell lectin like receptor K1) gene which is located in the NK-gene complex (NKC) situated on chromosome 6 in mice and chromosome 12 in humans. In mice, it is expressed by
3811:
1787:
Brown MG, Fulmek S, Matsumoto K, Cho R, Lyons PA, Levy ER, et al. (May 1997). "A 2-Mb YAC contig and physical map of the natural killer gene complex on mouse chromosome 6".
342:
241:
1987:
Li P, Morris DL, Willcox BE, Steinle A, Spies T, Strong RK (May 2001). "Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA".
3203:
Rabinovich B, Li J, Wolfson M, Lawrence W, Beers C, Chalupny J, et al. (April 2006). "NKG2D splice variants: a reexamination of adaptor molecule associations".
1909:
Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T (July 1999). "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA".
3595:"Natural killer group 2D and CD28 receptors differentially activate mammalian/mechanistic target of rapamycin to alter murine effector CD8+ T-cell differentiation"
4662:
1274:
1822:
Yabe T, McSherry C, Bach FH, Fisch P, Schall RP, Sondel PM, Houchins JP (1993). "A multigene family on human chromosome 12 encodes natural killer-cell lectins".
1451:
molecular mechanisms of this type of regulation are unknown. In posttranscriptional regulation, stabilization of NKG2D ligand mRNA plays a key role. For example
3385:"Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function"
1387:
4642:
1327:
164:
879:
860:
5504:
3828:
3804:
1604:, priming is not required, however NKG2D expression is constitutive while solely triggering NKG2D in γδ T cells does not mediate cytotoxicity.
5235:
2763:
González S, López-Soto A, Suarez-Alvarez B, López-Vázquez A, López-Larrea C (August 2008). "NKG2D ligands: key targets of the immune response".
1484:
for NKG2D. NKG2D is thought to be important in viral control as viruses have adapted mechanisms by which to evade NKG2D responses. For example,
5223:
5001:
2487:
Sancar A, Lindsey-Boltz LA, Unsal-Kaçmaz K, Linn S (June 2004). "Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints".
1427:
1303:
5836:
5287:
5282:
5228:
5008:
3789:
1720:
1702:
4741:
4667:
3797:
1740:"DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells"
2438:"The DNA Damage Response: A Common Pathway in the Regulation of NKG2D and DNAM-1 Ligand Expression in Normal, Infected, and Cancer Cells"
135:, CD314, D12S2489E, KLR, NKG2-D, NKG2D, natural killer group 2D, killer cell lectin-like receptor K1, killer cell lectin like receptor K1
5770:
5765:
5760:
5755:
4682:
1492:, which binds to NKG2D ligands ULBP1 and 2 (thus their name "UL16-binding protein") and MICB, which prevents their surface expression.
1241:
In mice, alternative splicing generates two distinct NKG2D isoforms: the long one (NKG2D-L) and the short one (NKG2D-S). NKG2D-L binds
328:
1102:
1095:
3469:"NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice"
5735:
3281:
Horng T, Bezbradica JS, Medzhitov R (December 2007). "NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway".
305:
4971:
5539:
5033:
4719:
3644:"NKG2D signaling on CD8⁺ T cells represses T-bet and rescues CD4-unhelped CD8⁺ T cell memory recall but not effector responses"
1689:
1668:
5178:
4714:
227:
202:
1685:
1521:
Interventions to increase senescent cell surface ligands of the
Natural Killer cell receptor NKG2D have been proposed as a
63:
5675:
5147:
5142:
5087:
4821:
4270:
2524:"Alternative Splice Transcripts for MHC Class I-like MICA Encode Novel NKG2D Ligands with Agonist or Antagonist Functions"
1299:
1664:
5369:
5092:
3554:"NKG2D induces Mcl-1 expression and mediates survival of CD8 memory T cell precursors via phosphatidylinositol 3-kinase"
144:
3696:"Altered NK cell development and enhanced NK cell-mediated resistance to mouse cytomegalovirus in NKG2D-deficient mice"
3063:"Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging"
4687:
1423:
1205:
from MIC and RAET1/ULBP families which appear on the surface of stressed, malignant transformed, and infected cells.
341:
240:
1226:
functions as an adaptor protein and transduces the signal after the ligand binding by recruiting the p85 subunit of
5399:
3824:
2852:"Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein"
1560:
predominance of long forms of NKG2D is typical, while in activated cells there is a higher number of short forms.
334:
233:
4265:
1310:
All NKG2D ligands are homologous to MHC class I molecules and are divided into two families: MIC and RAET1/ULBP.
1258:
1227:
5449:
4344:
924:
152:
2032:"The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure"
2665:"Immunological visibility: posttranscriptional regulation of human NKG2D ligands by the EGF receptor pathway"
5413:
1564:
905:
4756:
4751:
4746:
4736:
4043:
3971:
3326:"Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB"
4100:
4018:
2344:
Carapito R, Bahram S (September 2015). "Genetics, genomics, and evolutionary biology of NKG2D ligands".
1174:
216:
5337:
5050:
3383:
Hedlund M, Stenqvist AC, Nagaeva O, Kjellberg L, Wulff M, Baranov V, Mincheva-Nilsson L (July 2009).
3337:
2617:
2297:
2043:
1553:
1481:
1411:
1294:
1202:
131:
5846:
5364:
5183:
3552:
Wensveen FM, Lenartic M, Jelencic V, Lemmermann NA, ten Brinke A, Jonjic S, Polic B (August 2013).
3467:
Kavazović I, Lenartić M, Jelenčić V, Jurković S, Lemmermann NA, Jonjić S, et al. (July 2017).
2604:
Eagle RA, Flack G, Warford A, Martínez-Borra J, Jafferji I, Traherne JA, et al. (2009-02-18).
1631:
1549:
1515:
1395:
1190:
1170:
1074:
1070:
1049:
1019:
1015:
785:
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
3694:
Zafirova B, Mandarić S, Antulov R, Krmpotić A, Jonsson H, Yokoyama WM, et al. (August 2009).
3048:
2522:
Gavlovsky PJ, Tonnerre P, Gérard N, Nedellec S, Daman AW, McFarland BJ, Charreau B (August 2016).
5841:
4771:
4505:
3449:
3306:
3228:
2978:
2881:
2369:
2212:
2162:
2118:
2012:
1969:
1847:
1601:
1194:
1178:
176:
2850:
Welte SA, Sinzger C, Lutz SZ, Singh-Jasuja H, Sampaio KL, Eknigk U, et al. (January 2003).
1078:
1023:
994:
3246:
Di Santo JP (April 2006). "Natural killer cell developmental pathways: a question of balance".
2712:
Zingoni A, Molfetta R, Fionda C, Soriani A, Paolini R, Cippitelli M, et al. (2018-03-12).
3776:
3725:
3673:
3642:
Zloza A, Kohlhapp FJ, Lyons GE, Schenkel JM, Moore TV, Lacek AT, et al. (February 2012).
3624:
3575:
3531:
3490:
3441:
3406:
3365:
3298:
3263:
3220:
3185:
3144:
3092:
3030:
2970:
2925:
2873:
2832:
2780:
2745:
2694:
2645:
2586:
2545:
2504:
2469:
2418:
2361:
2323:
2261:
2204:
2154:
2110:
2071:
2004:
1961:
1926:
1891:
1839:
1804:
1769:
124:
56:
3259:
2999:
Sagiv A, Burton DG, Moshayev Z, Vadai E, Wensveen F, Ben-Dor S, et al. (February 2016).
2663:
Vantourout P, Willcox C, Turner A, Swanson CM, Haque Y, Sobolev O, et al. (April 2014).
2500:
5544:
5277:
5198:
4761:
3954:
3880:
3766:
3756:
3715:
3707:
3663:
3655:
3614:
3606:
3565:
3521:
3480:
3433:
3396:
3355:
3345:
3290:
3255:
3212:
3175:
3134:
3126:
3082:
3074:
3020:
3012:
2960:
2952:
2915:
2863:
2822:
2814:
2772:
2735:
2725:
2684:
2676:
2635:
2625:
2576:
2535:
2496:
2459:
2449:
2436:
Cerboni C, Fionda C, Soriani A, Zingoni A, Doria M, Cippitelli M, Santoni A (January 2014).
2408:
2400:
2353:
2313:
2305:
2251:
2243:
2196:
2146:
2102:
2061:
2051:
1996:
1953:
1918:
1881:
1831:
1796:
1759:
1751:
1538:
1419:
1198:
1182:
421:
352:
296:
251:
3061:
Muñoz DP, Yannone SM, Daemen A, Sun Y, Vakar-Lopez F, Kawahara M, et al. (June 2019).
172:
5604:
4140:
4135:
4058:
2247:
1588:
1502:
1489:
1485:
396:
3341:
2621:
2301:
2047:
5389:
4811:
4322:
4125:
3771:
3744:
3720:
3695:
3668:
3643:
3619:
3594:
3164:"Developmental pathways that generate natural-killer-cell diversity in mice and humans"
3139:
3114:
3087:
3062:
3025:
3000:
2920:
2903:
2827:
2802:
2740:
2713:
2689:
2664:
2640:
2605:
2464:
2437:
2413:
2388:
2318:
2285:
2256:
2231:
2066:
2031:
1764:
1739:
1592:
39:
2606:"Cellular expression, trafficking, and function of two isoforms of human ULBP5/RAET1G"
2185:"NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation"
1886:
1869:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
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739:
734:
729:
724:
719:
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709:
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683:
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668:
663:
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637:
632:
627:
622:
617:
612:
5830:
5359:
4816:
3907:
3360:
3325:
2982:
2373:
2286:"The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor"
1245:
similarly to human NKG2D. By contrast, NKG2D-S associates with two adaptor proteins:
1162:
599:
3453:
3310:
3232:
2885:
2166:
2122:
2016:
1973:
1870:"The role of the NKG2D immunoreceptor in immune cell activation and natural killing"
1851:
1378:. In mice, proteins from orthologous RAET1/ULBP family fall into three subfamilies:
156:
5715:
5023:
5013:
4544:
4510:
2216:
1868:
Jamieson AM, Diefenbach A, McMahon CW, Xiong N, Carlyle JR, Raulet DH (July 2002).
1641:
1537:
Therefore, NKG2D is implicated in NK and other immune cells activation through the
1407:
1379:
414:
193:
3711:
2680:
2630:
1922:
1406:
NKG2D ligand expression is regulated on multiple levels such as transcriptional,
180:
5725:
5374:
5152:
5127:
4826:
4448:
4374:
3848:
1725:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1707:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1254:
1246:
1242:
1223:
1219:
1214:
3330:
Proceedings of the
National Academy of Sciences of the United States of America
3078:
2036:
Proceedings of the
National Academy of Sciences of the United States of America
1944:
Raulet DH (October 2003). "Roles of the NKG2D immunoreceptor and its ligands".
497:
5655:
5379:
5060:
4801:
4677:
4310:
4305:
4300:
4155:
3939:
3216:
3130:
2818:
2803:"Regulation of immune cell function and differentiation by the NKG2D receptor"
2404:
1383:
1186:
313:
210:
160:
3761:
3570:
3553:
3526:
3509:
3401:
3384:
2776:
2730:
2540:
2523:
2454:
1422:
is able to activate a DNA damage response (DDR). Ligation of sensor kinases
5494:
5489:
5484:
5474:
5469:
5464:
5459:
3350:
3324:
Groh V, Rhinehart R, Secrist H, Bauer S, Grabstein KH, Spies T (June 1999).
2581:
2564:
2056:
1626:
1522:
1465:
1415:
824:
557:
435:
380:
367:
279:
266:
168:
3780:
3729:
3677:
3628:
3579:
3535:
3494:
3445:
3410:
3369:
3302:
3267:
3224:
3189:
3148:
3096:
3034:
2974:
2929:
2877:
2868:
2851:
2836:
2784:
2749:
2698:
2649:
2590:
2549:
2508:
2473:
2422:
2389:"Targeting senescent cells to attenuate cardiovascular disease progression"
2365:
2327:
2265:
2208:
2158:
2114:
2075:
2008:
1965:
1930:
1895:
1800:
1755:
3485:
3468:
3016:
1843:
1808:
1773:
1322:
genes are located within the MHC locus and are composed of seven members (
1142:
1137:
5800:
5700:
5514:
5499:
4702:
4697:
4605:
4295:
2956:
1596:
1126:
969:
950:
2965:
2309:
5750:
5745:
5740:
5640:
5454:
5444:
5271:
5250:
5245:
5213:
5018:
4938:
4933:
4928:
4923:
4918:
4836:
4529:
4369:
4364:
4359:
4354:
4349:
3820:
1835:
936:
891:
3689:
3687:
3610:
2563:
Cao W, Xi X, Wang Z, Dong L, Hao Z, Cui L, et al. (August 2008).
2357:
2279:
2277:
2275:
101:
97:
93:
89:
85:
5690:
5650:
5635:
5619:
5614:
5594:
5589:
5524:
5332:
5302:
5266:
5257:
5070:
5038:
4902:
4897:
4867:
4846:
4806:
4766:
4632:
4610:
4569:
4493:
4488:
4483:
4478:
4473:
4468:
4337:
4332:
4327:
4275:
4260:
4130:
4120:
4083:
4078:
3996:
3991:
2183:
Gilfillan S, Ho EL, Cella M, Yokoyama WM, Colonna M (December 2002).
1584:
1469:
1371:
1359:
1355:
1270:
1250:
1110:
846:
17:
3659:
3180:
3163:
2184:
1957:
3593:
McQueen B, Trace K, Whitman E, Bedsworth T, Barber A (March 2016).
3294:
3047:
Sagiv A, Biran A, Yon M, Simon J, Lowe SW, Krizhanovsky V. (2013).
2106:
1157:
is an activating receptor (transmembrane protein) belonging to the
5815:
5790:
5710:
5705:
5695:
5670:
5665:
5660:
5645:
5599:
5584:
5549:
5534:
5529:
5519:
5439:
5434:
5429:
5408:
5404:
5394:
5307:
5208:
5203:
5162:
5112:
5107:
5102:
5097:
5082:
5075:
5055:
5043:
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4954:
4892:
4882:
4877:
4872:
4862:
4841:
4831:
4796:
4791:
4786:
4781:
4776:
4731:
4726:
4692:
4657:
4652:
4647:
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4625:
4620:
4600:
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4590:
4585:
4539:
4431:
4426:
4245:
4229:
4222:
4217:
4212:
4207:
4202:
4197:
4172:
4150:
4145:
4038:
3964:
3959:
3949:
3437:
3049:
Granule exocytosis mediates immune surveillance of senescent cells
2200:
2150:
2000:
1480:
Viruses, as intracellular pathogens, can induce the expression of
1452:
1435:
1431:
1391:
1375:
1367:
1363:
1282:
809:
805:
5810:
5805:
5795:
5785:
5780:
5775:
5730:
5720:
5680:
5609:
5579:
5574:
5569:
5564:
5559:
5554:
5509:
5479:
5384:
5352:
5347:
5327:
5317:
5312:
5297:
5292:
5193:
5188:
5157:
5137:
5132:
5122:
5117:
4996:
4949:
4909:
4564:
4559:
4554:
4549:
4534:
4525:
4520:
4515:
4500:
4458:
4453:
4443:
4438:
4421:
4416:
4411:
4406:
4401:
4396:
4391:
4386:
4381:
4317:
4290:
4285:
4280:
4255:
4250:
4187:
4182:
4177:
4167:
4162:
4115:
4110:
4105:
4095:
4090:
4073:
4068:
4063:
4053:
4048:
4033:
4028:
4023:
4013:
4008:
4003:
3986:
3981:
3976:
3927:
3895:
3890:
3885:
3868:
3863:
3858:
3853:
1636:
1334:
1266:
1262:
1238:
complex which are responsible for subsequent downstream events.
1235:
1231:
1158:
760:
positive regulation of natural killer cell mediated cytotoxicity
148:
3793:
5322:
3934:
3922:
3917:
3912:
3902:
3875:
3843:
1278:
3162:
Huntington ND, Vosshenrich CA, Di Santo JP (September 2007).
3001:"NKG2D ligands mediate immunosurveillance of senescent cells"
2565:"Four novel ULBP splice variants are ligands for human NKG2D"
1430:
leads to activation of different checkpoint kinases, such as
3508:
Nedellec S, Sabourin C, Bonneville M, Scotet E (July 2010).
2230:
Raulet DH, Gasser S, Gowen BG, Deng W, Jung H (2013-01-01).
2801:
Zafirova B, Wensveen FM, Gulin M, Polić B (November 2011).
3745:"NKG2D: A Master Regulator of Immune Cell Responsiveness"
2232:"Regulation of ligands for the NKG2D activating receptor"
2030:
Garrity D, Call ME, Feng J, Wucherpfennig KW (May 2005).
2284:
Gasser S, Orsulic S, Brown EJ, Raulet DH (August 2005).
1501:
present on the cell surface of tumor cells by secreting
790:
positive regulation of myeloid dendritic cell activation
715:
positive regulation of nitric oxide biosynthetic process
404:
2904:"Role of NKG2D and its ligands in cancer immunotherapy"
1738:
Houchins JP, Yabe T, McSherry C, Bach FH (April 1991).
1514:
As part of the DNA damage response during induction of
3547:
3545:
2902:
Liu H, Wang S, Xin J, Wang J, Yao C, Zhang Z (2019).
720:
negative regulation of natural killer cell chemotaxis
569:
740:
stimulatory C-type lectin receptor signaling pathway
5628:
5422:
5171:
4855:
4578:
4238:
3836:
2714:"NKG2D and Its Ligands: "One for All, All for One""
1063:
1042:
1008:
987:
1681:
1679:
1677:
1660:
1658:
1656:
735:positive regulation of interferon-gamma production
351:
250:
3051:Oncogene, 32, 1971–197, doi:10.1038/onc.2012.206
2339:
2337:
3743:Wensveen FM, Jelenčić V, Polić B (2018-03-08).
2994:
2992:
2796:
2794:
1863:
1861:
27:Protein-coding gene in the species Homo sapiens
2087:
2085:
1686:GRCm38: Ensembl release 89: ENSMUSG00000030149
3805:
2178:
2176:
8:
1665:GRCh38: Ensembl release 89: ENSG00000213809
1438:, which are important for the induction of
770:defense response to Gram-positive bacterium
3812:
3798:
3790:
1394:is a stress-induced ligand often found on
820:
595:
392:
291:
188:
74:
3829:list of human clusters of differentiation
3770:
3760:
3719:
3667:
3618:
3569:
3525:
3484:
3400:
3359:
3349:
3179:
3138:
3086:
3024:
2964:
2919:
2867:
2826:
2739:
2729:
2688:
2639:
2629:
2580:
2539:
2463:
2453:
2412:
2317:
2255:
2065:
2055:
1885:
1763:
1338:produce functional transcripts. In mice,
780:natural killer cell mediated cytotoxicity
3260:10.1146/annurev.immunol.24.021605.090700
2501:10.1146/annurev.biochem.73.011303.073723
795:positive regulation of apoptotic process
1652:
1354:genes, six encode functional proteins:
1277:and activates protein tyrosine kinases
755:cellular response to lipopolysaccharide
745:negative regulation of GTPase activity
29:
3108:
3106:
2897:
2895:
2248:10.1146/annurev-immunol-032712-095951
669:integral component of plasma membrane
356:
317:
312:
255:
214:
209:
7:
2807:Cellular and Molecular Life Sciences
2387:Song P, Zhao Q, Zou MH (July 2020).
1744:The Journal of Experimental Medicine
2908:American Journal of Cancer Research
1525:therapy to remove senescent cells.
1060:
1039:
1005:
984:
960:
941:
915:
896:
870:
851:
574:
492:
430:
409:
25:
3115:"NKG2D and its ligands in cancer"
613:protein homodimerization activity
1189:. In humans, it is expressed by
679:external side of plasma membrane
520:extensor digitorum longus muscle
340:
333:
327:
304:
239:
232:
226:
201:
38:
3473:European Journal of Immunology
2856:European Journal of Immunology
2669:Science Translational Medicine
1510:Role in senescent cell removal
730:natural killer cell activation
659:integral component of membrane
623:MHC class Ib receptor activity
558:More reference expression data
1:
3119:Current Opinion in Immunology
2489:Annual Review of Biochemistry
1887:10.1016/S1074-7613(02)00333-3
1468:or genomic stress such as in
750:regulation of immune response
325:
224:
5837:Genes on human chromosome 12
3712:10.1016/j.immuni.2009.06.017
3113:Dhar P, Wu JD (April 2018).
2681:10.1126/scitranslmed.3007579
2631:10.1371/journal.pone.0004503
1923:10.1126/science.285.5428.727
1257:recruits the p85 subunit of
1163:C-type lectin-like receptors
3825:clusters of differentiation
3248:Annual Review of Immunology
2945:Immunology and Cell Biology
2236:Annual Review of Immunology
638:signaling receptor activity
628:MHC class I protein binding
5863:
3168:Nature Reviews. Immunology
3079:10.1172/jci.insight.124716
1946:Nature Reviews. Immunology
1595:by membrane receptors and
508:superior surface of tongue
474:mucosa of transverse colon
3217:10.1007/s00251-005-0078-x
3131:10.1016/j.coi.2018.02.004
2819:10.1007/s00018-011-0797-0
2405:10.1016/j.arr.2020.101072
1721:"Mouse PubMed Reference:"
1703:"Human PubMed Reference:"
1600:and cytolytic killing by
1488:(CMV) encodes a protein,
1414:, proliferation signals,
1141:
1136:
1132:
1125:
1109:
1090:
1067:
1046:
1035:
1012:
991:
980:
967:
963:
948:
944:
935:
922:
918:
903:
899:
890:
877:
873:
858:
854:
845:
830:
823:
819:
803:
598:
594:
582:
577:
568:
555:
504:
495:
442:
433:
403:
395:
391:
374:
361:
324:
303:
294:
290:
273:
260:
223:
200:
191:
187:
142:
139:
129:
122:
117:
82:
77:
60:
55:
50:
46:
37:
32:
3762:10.3389/fimmu.2018.00441
3571:10.4049/jimmunol.1300670
3527:10.4049/jimmunol.1000373
3402:10.4049/jimmunol.0803477
2777:10.1016/j.it.2008.04.007
2731:10.3389/fimmu.2018.00476
2569:International Immunology
2541:10.4049/jimmunol.1501416
2455:10.3389/fimmu.2013.00508
1103:Chr 6: 129.59 – 129.6 Mb
1096:Chr 12: 10.37 – 10.39 Mb
705:adaptive immune response
3749:Frontiers in Immunology
3351:10.1073/pnas.96.12.6879
2718:Frontiers in Immunology
2442:Frontiers in Immunology
2393:Ageing Research Reviews
2057:10.1073/pnas.0502439102
1587:, binding of ligand on
1476:Role in viral infection
1402:NKG2D ligand regulation
544:interventricular septum
470:upper lobe of left lung
2869:10.1002/immu.200390022
1801:10.1006/geno.1997.4721
1756:10.1084/jem.173.4.1017
1350:Among ten known human
1165:. NKG2D is encoded by
775:innate immune response
536:mesenteric lymph nodes
3558:Journal of Immunology
3514:Journal of Immunology
3486:10.1002/eji.201646805
3389:Journal of Immunology
3017:10.18632/aging.100897
2582:10.1093/intimm/dxn057
2528:Journal of Immunology
2346:Immunological Reviews
1496:Role in tumor control
1295:induced-self proteins
1203:induced-self proteins
710:immune system process
217:Chromosome 12 (human)
2957:10.1038/icb.2010.100
2765:Trends in Immunology
725:T cell costimulation
700:cell differentiation
633:carbohydrate binding
358:6 F3|6 63.44 cM
319:Chromosome 6 (mouse)
78:List of PDB id codes
51:Available structures
3342:1999PNAS...96.6879G
2622:2009PLoSO...4.4503E
2310:10.1038/nature03884
2302:2005Natur.436.1186G
2048:2005PNAS..102.7641G
1632:Natural killer cell
1516:cellular senescence
1201:. NKG2D recognizes
765:signal transduction
1836:10.1007/BF00222470
1552:are a key part of
1545:NKG2D and NK cells
1342:genes are absent.
1293:NKG2D ligands are
925:ENSMUSG00000030149
693:Biological process
652:Cellular component
606:Molecular function
5824:
5823:
3611:10.1111/imm.12563
3426:Nature Immunology
3283:Nature Immunology
2914:(10): 2064–2078.
2358:10.1111/imr.12328
2296:(7054): 1186–90.
2189:Nature Immunology
2139:Nature Immunology
2095:Nature Immunology
1989:Nature Immunology
1612:NKG2D and B cells
1579:NKG2D and T cells
1563:Interaction with
1346:RAET1/ULBP family
1326:), of which only
1261:and a complex of
1152:
1151:
1148:
1147:
1121:
1120:
1086:
1085:
1057:
1056:
1031:
1030:
1002:
1001:
976:
975:
957:
956:
931:
930:
912:
911:
886:
885:
867:
866:
815:
814:
590:
589:
586:
585:
564:
563:
551:
550:
489:
488:
387:
386:
286:
285:
181:KLRK1 - orthologs
113:
112:
109:
108:
61:Ortholog search:
16:(Redirected from
5854:
3814:
3807:
3800:
3791:
3785:
3784:
3774:
3764:
3740:
3734:
3733:
3723:
3691:
3682:
3681:
3671:
3639:
3633:
3632:
3622:
3590:
3584:
3583:
3573:
3549:
3540:
3539:
3529:
3505:
3499:
3498:
3488:
3479:(7): 1123–1135.
3464:
3458:
3457:
3421:
3415:
3414:
3404:
3380:
3374:
3373:
3363:
3353:
3321:
3315:
3314:
3278:
3272:
3271:
3243:
3237:
3236:
3200:
3194:
3193:
3183:
3159:
3153:
3152:
3142:
3110:
3101:
3100:
3090:
3058:
3052:
3045:
3039:
3038:
3028:
2996:
2987:
2986:
2968:
2940:
2934:
2933:
2923:
2899:
2890:
2889:
2871:
2847:
2841:
2840:
2830:
2798:
2789:
2788:
2760:
2754:
2753:
2743:
2733:
2709:
2703:
2702:
2692:
2675:(231): 231ra49.
2660:
2654:
2653:
2643:
2633:
2601:
2595:
2594:
2584:
2560:
2554:
2553:
2543:
2519:
2513:
2512:
2484:
2478:
2477:
2467:
2457:
2433:
2427:
2426:
2416:
2384:
2378:
2377:
2341:
2332:
2331:
2321:
2281:
2270:
2269:
2259:
2227:
2221:
2220:
2180:
2171:
2170:
2133:
2127:
2126:
2089:
2080:
2079:
2069:
2059:
2027:
2021:
2020:
1984:
1978:
1977:
1941:
1935:
1934:
1906:
1900:
1899:
1889:
1865:
1856:
1855:
1819:
1813:
1812:
1784:
1778:
1777:
1767:
1735:
1729:
1728:
1717:
1711:
1710:
1699:
1693:
1683:
1672:
1662:
1589:T cell receptors
1539:PI3K-AKT pathway
1529:NKG2D signalling
1503:metalloproteases
1420:oxidative stress
1134:
1133:
1105:
1098:
1081:
1061:
1052:
1040:
1036:RefSeq (protein)
1026:
1006:
997:
985:
961:
942:
916:
897:
871:
852:
821:
596:
575:
560:
516:plantaris muscle
500:
498:Top expressed in
493:
438:
436:Top expressed in
431:
410:
393:
383:
370:
359:
344:
337:
331:
320:
308:
292:
282:
269:
258:
243:
236:
230:
219:
205:
189:
183:
134:
127:
104:
75:
69:
48:
47:
42:
30:
21:
5862:
5861:
5857:
5856:
5855:
5853:
5852:
5851:
5827:
5826:
5825:
5820:
5624:
5418:
5167:
4851:
4574:
4234:
3832:
3818:
3788:
3742:
3741:
3737:
3693:
3692:
3685:
3660:10.1038/nm.2683
3648:Nature Medicine
3641:
3640:
3636:
3592:
3591:
3587:
3551:
3550:
3543:
3507:
3506:
3502:
3466:
3465:
3461:
3423:
3422:
3418:
3382:
3381:
3377:
3336:(12): 6879–84.
3323:
3322:
3318:
3289:(12): 1345–52.
3280:
3279:
3275:
3245:
3244:
3240:
3202:
3201:
3197:
3181:10.1038/nri2154
3161:
3160:
3156:
3112:
3111:
3104:
3060:
3059:
3055:
3046:
3042:
2998:
2997:
2990:
2942:
2941:
2937:
2901:
2900:
2893:
2849:
2848:
2844:
2813:(21): 3519–29.
2800:
2799:
2792:
2762:
2761:
2757:
2711:
2710:
2706:
2662:
2661:
2657:
2603:
2602:
2598:
2562:
2561:
2557:
2521:
2520:
2516:
2486:
2485:
2481:
2435:
2434:
2430:
2386:
2385:
2381:
2343:
2342:
2335:
2283:
2282:
2273:
2229:
2228:
2224:
2182:
2181:
2174:
2135:
2134:
2130:
2091:
2090:
2083:
2029:
2028:
2024:
1986:
1985:
1981:
1958:10.1038/nri1199
1943:
1942:
1938:
1917:(5428): 727–9.
1908:
1907:
1903:
1867:
1866:
1859:
1821:
1820:
1816:
1786:
1785:
1781:
1737:
1736:
1732:
1719:
1718:
1714:
1701:
1700:
1696:
1684:
1675:
1663:
1654:
1650:
1623:
1614:
1583:For priming of
1581:
1554:innate immunity
1547:
1531:
1512:
1498:
1486:cytomegalovirus
1478:
1462:
1404:
1396:senescent cells
1348:
1316:
1291:
1211:
1143:View/Edit Mouse
1138:View/Edit Human
1101:
1094:
1091:Location (UCSC)
1077:
1073:
1069:
1048:
1022:
1018:
1014:
993:
906:ENSG00000213809
799:
688:
684:plasma membrane
647:
618:protein binding
556:
547:
542:
538:
534:
530:
526:
522:
518:
514:
510:
496:
485:
480:
476:
472:
468:
464:
460:
456:
452:
448:
434:
378:
365:
357:
347:
346:
345:
338:
318:
295:Gene location (
277:
264:
256:
246:
245:
244:
237:
215:
192:Gene location (
143:
130:
123:
84:
62:
28:
23:
22:
15:
12:
11:
5:
5860:
5858:
5850:
5849:
5844:
5839:
5829:
5828:
5822:
5821:
5819:
5818:
5813:
5808:
5803:
5798:
5793:
5788:
5783:
5778:
5773:
5768:
5763:
5758:
5753:
5748:
5743:
5738:
5733:
5728:
5723:
5718:
5713:
5708:
5703:
5698:
5693:
5688:
5683:
5678:
5673:
5668:
5663:
5658:
5653:
5648:
5643:
5638:
5632:
5630:
5626:
5625:
5623:
5622:
5617:
5612:
5607:
5602:
5597:
5592:
5587:
5582:
5577:
5572:
5567:
5562:
5557:
5552:
5547:
5542:
5537:
5532:
5527:
5522:
5517:
5512:
5507:
5502:
5497:
5492:
5487:
5482:
5477:
5472:
5467:
5462:
5457:
5452:
5447:
5442:
5437:
5432:
5426:
5424:
5420:
5419:
5417:
5416:
5411:
5402:
5397:
5392:
5387:
5382:
5377:
5372:
5367:
5362:
5357:
5356:
5355:
5350:
5340:
5335:
5330:
5325:
5320:
5315:
5310:
5305:
5300:
5295:
5290:
5285:
5280:
5275:
5269:
5260:
5255:
5254:
5253:
5248:
5238:
5233:
5232:
5231:
5226:
5216:
5211:
5206:
5201:
5196:
5191:
5186:
5181:
5175:
5173:
5169:
5168:
5166:
5165:
5160:
5155:
5150:
5145:
5140:
5135:
5130:
5125:
5120:
5115:
5110:
5105:
5100:
5095:
5090:
5085:
5080:
5079:
5078:
5073:
5063:
5058:
5053:
5048:
5047:
5046:
5041:
5036:
5026:
5021:
5016:
5011:
5006:
5005:
5004:
4999:
4989:
4984:
4979:
4974:
4969:
4964:
4959:
4958:
4957:
4952:
4942:
4936:
4931:
4926:
4921:
4912:
4907:
4906:
4905:
4900:
4895:
4885:
4880:
4875:
4870:
4865:
4859:
4857:
4853:
4852:
4850:
4849:
4844:
4839:
4834:
4829:
4824:
4819:
4814:
4809:
4804:
4799:
4794:
4789:
4784:
4779:
4774:
4769:
4764:
4759:
4754:
4749:
4744:
4739:
4734:
4729:
4724:
4723:
4722:
4717:
4707:
4706:
4705:
4700:
4690:
4685:
4680:
4675:
4670:
4665:
4660:
4655:
4650:
4645:
4640:
4635:
4630:
4629:
4628:
4623:
4613:
4608:
4603:
4598:
4593:
4588:
4582:
4580:
4576:
4575:
4573:
4572:
4567:
4562:
4557:
4552:
4547:
4542:
4537:
4532:
4523:
4518:
4513:
4508:
4503:
4498:
4497:
4496:
4491:
4486:
4481:
4476:
4471:
4461:
4456:
4451:
4446:
4441:
4436:
4435:
4434:
4429:
4419:
4414:
4409:
4404:
4399:
4394:
4389:
4384:
4379:
4378:
4377:
4372:
4367:
4362:
4357:
4352:
4342:
4341:
4340:
4335:
4330:
4320:
4315:
4314:
4313:
4308:
4303:
4293:
4288:
4283:
4278:
4273:
4268:
4263:
4258:
4253:
4248:
4242:
4240:
4236:
4235:
4233:
4232:
4227:
4226:
4225:
4220:
4215:
4210:
4205:
4200:
4190:
4185:
4180:
4175:
4170:
4165:
4160:
4159:
4158:
4153:
4148:
4143:
4133:
4128:
4123:
4118:
4113:
4108:
4103:
4098:
4093:
4088:
4087:
4086:
4081:
4071:
4066:
4061:
4056:
4051:
4046:
4041:
4036:
4031:
4026:
4021:
4016:
4011:
4006:
4001:
4000:
3999:
3994:
3984:
3979:
3974:
3969:
3968:
3967:
3962:
3957:
3952:
3942:
3937:
3932:
3931:
3930:
3920:
3915:
3910:
3905:
3900:
3899:
3898:
3893:
3888:
3878:
3873:
3872:
3871:
3866:
3861:
3856:
3851:
3840:
3838:
3834:
3833:
3819:
3817:
3816:
3809:
3802:
3794:
3787:
3786:
3735:
3683:
3634:
3585:
3564:(3): 1307–15.
3541:
3500:
3459:
3416:
3375:
3316:
3295:10.1038/ni1524
3273:
3238:
3205:Immunogenetics
3195:
3154:
3102:
3073:(14): 124716.
3053:
3040:
2988:
2935:
2891:
2862:(1): 194–203.
2842:
2790:
2771:(8): 397–403.
2755:
2704:
2655:
2596:
2555:
2514:
2479:
2428:
2379:
2333:
2271:
2222:
2195:(12): 1150–5.
2172:
2145:(12): 1142–9.
2128:
2107:10.1038/ni1325
2081:
2042:(21): 7641–6.
2022:
1979:
1952:(10): 781–90.
1936:
1901:
1857:
1824:Immunogenetics
1814:
1779:
1750:(4): 1017–20.
1730:
1712:
1694:
1673:
1651:
1649:
1646:
1645:
1644:
1639:
1634:
1629:
1622:
1619:
1613:
1610:
1593:co-stimulation
1580:
1577:
1565:IL-15 receptor
1546:
1543:
1530:
1527:
1511:
1508:
1497:
1494:
1482:stress ligands
1477:
1474:
1461:
1458:
1403:
1400:
1347:
1344:
1315:
1312:
1290:
1287:
1210:
1207:
1199:CD8 αβ T cells
1185:and activated
1183:CD8 αβ T cells
1150:
1149:
1146:
1145:
1140:
1130:
1129:
1123:
1122:
1119:
1118:
1116:
1114:
1107:
1106:
1099:
1092:
1088:
1087:
1084:
1083:
1065:
1064:
1058:
1055:
1054:
1044:
1043:
1037:
1033:
1032:
1029:
1028:
1010:
1009:
1003:
1000:
999:
989:
988:
982:
978:
977:
974:
973:
965:
964:
958:
955:
954:
946:
945:
939:
933:
932:
929:
928:
920:
919:
913:
910:
909:
901:
900:
894:
888:
887:
884:
883:
875:
874:
868:
865:
864:
856:
855:
849:
843:
842:
837:
832:
828:
827:
817:
816:
813:
812:
801:
800:
798:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
696:
694:
690:
689:
687:
686:
681:
676:
671:
666:
661:
655:
653:
649:
648:
646:
645:
643:kinase binding
640:
635:
630:
625:
620:
615:
609:
607:
603:
602:
592:
591:
588:
587:
584:
583:
580:
579:
572:
566:
565:
562:
561:
553:
552:
549:
548:
546:
545:
541:
537:
533:
532:corneal stroma
529:
525:
521:
517:
513:
509:
505:
502:
501:
490:
487:
486:
484:
483:
479:
475:
471:
467:
463:
459:
455:
451:
447:
443:
440:
439:
427:
426:
418:
407:
401:
400:
397:RNA expression
389:
388:
385:
384:
376:
372:
371:
363:
360:
355:
349:
348:
339:
332:
326:
322:
321:
316:
310:
309:
301:
300:
288:
287:
284:
283:
275:
271:
270:
262:
259:
254:
248:
247:
238:
231:
225:
221:
220:
213:
207:
206:
198:
197:
185:
184:
141:
137:
136:
128:
120:
119:
115:
114:
111:
110:
107:
106:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5859:
5848:
5845:
5843:
5840:
5838:
5835:
5834:
5832:
5817:
5814:
5812:
5809:
5807:
5804:
5802:
5799:
5797:
5794:
5792:
5789:
5787:
5784:
5782:
5779:
5777:
5774:
5772:
5769:
5767:
5764:
5762:
5759:
5757:
5754:
5752:
5749:
5747:
5744:
5742:
5739:
5737:
5734:
5732:
5729:
5727:
5724:
5722:
5719:
5717:
5714:
5712:
5709:
5707:
5704:
5702:
5699:
5697:
5694:
5692:
5689:
5687:
5684:
5682:
5679:
5677:
5674:
5672:
5669:
5667:
5664:
5662:
5659:
5657:
5654:
5652:
5649:
5647:
5644:
5642:
5639:
5637:
5634:
5633:
5631:
5627:
5621:
5618:
5616:
5613:
5611:
5608:
5606:
5603:
5601:
5598:
5596:
5593:
5591:
5588:
5586:
5583:
5581:
5578:
5576:
5573:
5571:
5568:
5566:
5563:
5561:
5558:
5556:
5553:
5551:
5548:
5546:
5543:
5541:
5538:
5536:
5533:
5531:
5528:
5526:
5523:
5521:
5518:
5516:
5513:
5511:
5508:
5506:
5503:
5501:
5498:
5496:
5493:
5491:
5488:
5486:
5483:
5481:
5478:
5476:
5473:
5471:
5468:
5466:
5463:
5461:
5458:
5456:
5453:
5451:
5448:
5446:
5443:
5441:
5438:
5436:
5433:
5431:
5428:
5427:
5425:
5421:
5415:
5412:
5410:
5406:
5403:
5401:
5398:
5396:
5393:
5391:
5388:
5386:
5383:
5381:
5378:
5376:
5373:
5371:
5368:
5366:
5363:
5361:
5358:
5354:
5351:
5349:
5346:
5345:
5344:
5341:
5339:
5336:
5334:
5331:
5329:
5326:
5324:
5321:
5319:
5316:
5314:
5311:
5309:
5306:
5304:
5301:
5299:
5296:
5294:
5291:
5289:
5286:
5284:
5281:
5279:
5276:
5273:
5270:
5268:
5264:
5261:
5259:
5256:
5252:
5249:
5247:
5244:
5243:
5242:
5239:
5237:
5234:
5230:
5227:
5225:
5222:
5221:
5220:
5217:
5215:
5212:
5210:
5207:
5205:
5202:
5200:
5197:
5195:
5192:
5190:
5187:
5185:
5182:
5180:
5177:
5176:
5174:
5170:
5164:
5161:
5159:
5156:
5154:
5151:
5149:
5146:
5144:
5141:
5139:
5136:
5134:
5131:
5129:
5126:
5124:
5121:
5119:
5116:
5114:
5111:
5109:
5106:
5104:
5101:
5099:
5096:
5094:
5091:
5089:
5086:
5084:
5081:
5077:
5074:
5072:
5069:
5068:
5067:
5064:
5062:
5059:
5057:
5054:
5052:
5049:
5045:
5042:
5040:
5037:
5035:
5032:
5031:
5030:
5027:
5025:
5022:
5020:
5017:
5015:
5012:
5010:
5007:
5003:
5000:
4998:
4995:
4994:
4993:
4990:
4988:
4985:
4983:
4980:
4978:
4975:
4973:
4970:
4968:
4965:
4963:
4960:
4956:
4953:
4951:
4948:
4947:
4946:
4943:
4940:
4937:
4935:
4932:
4930:
4927:
4925:
4922:
4920:
4916:
4913:
4911:
4908:
4904:
4901:
4899:
4896:
4894:
4891:
4890:
4889:
4886:
4884:
4881:
4879:
4876:
4874:
4871:
4869:
4866:
4864:
4861:
4860:
4858:
4854:
4848:
4845:
4843:
4840:
4838:
4835:
4833:
4830:
4828:
4825:
4823:
4820:
4818:
4815:
4813:
4810:
4808:
4805:
4803:
4800:
4798:
4795:
4793:
4790:
4788:
4785:
4783:
4780:
4778:
4775:
4773:
4770:
4768:
4765:
4763:
4760:
4758:
4755:
4753:
4750:
4748:
4745:
4743:
4740:
4738:
4735:
4733:
4730:
4728:
4725:
4721:
4718:
4716:
4713:
4712:
4711:
4708:
4704:
4701:
4699:
4696:
4695:
4694:
4691:
4689:
4686:
4684:
4681:
4679:
4676:
4674:
4671:
4669:
4666:
4664:
4661:
4659:
4656:
4654:
4651:
4649:
4646:
4644:
4641:
4639:
4636:
4634:
4631:
4627:
4624:
4622:
4619:
4618:
4617:
4614:
4612:
4609:
4607:
4604:
4602:
4599:
4597:
4594:
4592:
4589:
4587:
4584:
4583:
4581:
4577:
4571:
4568:
4566:
4563:
4561:
4558:
4556:
4553:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4507:
4504:
4502:
4499:
4495:
4492:
4490:
4487:
4485:
4482:
4480:
4477:
4475:
4472:
4470:
4467:
4466:
4465:
4462:
4460:
4457:
4455:
4452:
4450:
4447:
4445:
4442:
4440:
4437:
4433:
4430:
4428:
4425:
4424:
4423:
4420:
4418:
4415:
4413:
4410:
4408:
4405:
4403:
4400:
4398:
4395:
4393:
4390:
4388:
4385:
4383:
4380:
4376:
4373:
4371:
4368:
4366:
4363:
4361:
4358:
4356:
4353:
4351:
4348:
4347:
4346:
4343:
4339:
4336:
4334:
4331:
4329:
4326:
4325:
4324:
4321:
4319:
4316:
4312:
4309:
4307:
4304:
4302:
4299:
4298:
4297:
4294:
4292:
4289:
4287:
4284:
4282:
4279:
4277:
4274:
4272:
4269:
4267:
4264:
4262:
4259:
4257:
4254:
4252:
4249:
4247:
4244:
4243:
4241:
4237:
4231:
4228:
4224:
4221:
4219:
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4199:
4196:
4195:
4194:
4191:
4189:
4186:
4184:
4181:
4179:
4176:
4174:
4171:
4169:
4166:
4164:
4161:
4157:
4154:
4152:
4149:
4147:
4144:
4142:
4139:
4138:
4137:
4134:
4132:
4129:
4127:
4124:
4122:
4119:
4117:
4114:
4112:
4109:
4107:
4104:
4102:
4099:
4097:
4094:
4092:
4089:
4085:
4082:
4080:
4077:
4076:
4075:
4072:
4070:
4067:
4065:
4062:
4060:
4057:
4055:
4052:
4050:
4047:
4045:
4042:
4040:
4037:
4035:
4032:
4030:
4027:
4025:
4022:
4020:
4017:
4015:
4012:
4010:
4007:
4005:
4002:
3998:
3995:
3993:
3990:
3989:
3988:
3985:
3983:
3980:
3978:
3975:
3973:
3970:
3966:
3963:
3961:
3958:
3956:
3953:
3951:
3948:
3947:
3946:
3943:
3941:
3938:
3936:
3933:
3929:
3926:
3925:
3924:
3921:
3919:
3916:
3914:
3911:
3909:
3906:
3904:
3901:
3897:
3894:
3892:
3889:
3887:
3884:
3883:
3882:
3879:
3877:
3874:
3870:
3867:
3865:
3862:
3860:
3857:
3855:
3852:
3850:
3847:
3846:
3845:
3842:
3841:
3839:
3835:
3830:
3826:
3822:
3815:
3810:
3808:
3803:
3801:
3796:
3795:
3792:
3782:
3778:
3773:
3768:
3763:
3758:
3754:
3750:
3746:
3739:
3736:
3731:
3727:
3722:
3717:
3713:
3709:
3706:(2): 270–82.
3705:
3701:
3697:
3690:
3688:
3684:
3679:
3675:
3670:
3665:
3661:
3657:
3653:
3649:
3645:
3638:
3635:
3630:
3626:
3621:
3616:
3612:
3608:
3605:(3): 305–20.
3604:
3600:
3596:
3589:
3586:
3581:
3577:
3572:
3567:
3563:
3559:
3555:
3548:
3546:
3542:
3537:
3533:
3528:
3523:
3519:
3515:
3511:
3504:
3501:
3496:
3492:
3487:
3482:
3478:
3474:
3470:
3463:
3460:
3455:
3451:
3447:
3443:
3439:
3438:10.1038/85321
3435:
3432:(3): 255–60.
3431:
3427:
3420:
3417:
3412:
3408:
3403:
3398:
3395:(1): 340–51.
3394:
3390:
3386:
3379:
3376:
3371:
3367:
3362:
3357:
3352:
3347:
3343:
3339:
3335:
3331:
3327:
3320:
3317:
3312:
3308:
3304:
3300:
3296:
3292:
3288:
3284:
3277:
3274:
3269:
3265:
3261:
3257:
3254:(1): 257–86.
3253:
3249:
3242:
3239:
3234:
3230:
3226:
3222:
3218:
3214:
3211:(2–3): 81–8.
3210:
3206:
3199:
3196:
3191:
3187:
3182:
3177:
3174:(9): 703–14.
3173:
3169:
3165:
3158:
3155:
3150:
3146:
3141:
3136:
3132:
3128:
3124:
3120:
3116:
3109:
3107:
3103:
3098:
3094:
3089:
3084:
3080:
3076:
3072:
3068:
3064:
3057:
3054:
3050:
3044:
3041:
3036:
3032:
3027:
3022:
3018:
3014:
3011:(2): 328–44.
3010:
3006:
3002:
2995:
2993:
2989:
2984:
2980:
2976:
2972:
2967:
2962:
2958:
2954:
2951:(3): 447–57.
2950:
2946:
2939:
2936:
2931:
2927:
2922:
2917:
2913:
2909:
2905:
2898:
2896:
2892:
2887:
2883:
2879:
2875:
2870:
2865:
2861:
2857:
2853:
2846:
2843:
2838:
2834:
2829:
2824:
2820:
2816:
2812:
2808:
2804:
2797:
2795:
2791:
2786:
2782:
2778:
2774:
2770:
2766:
2759:
2756:
2751:
2747:
2742:
2737:
2732:
2727:
2723:
2719:
2715:
2708:
2705:
2700:
2696:
2691:
2686:
2682:
2678:
2674:
2670:
2666:
2659:
2656:
2651:
2647:
2642:
2637:
2632:
2627:
2623:
2619:
2615:
2611:
2607:
2600:
2597:
2592:
2588:
2583:
2578:
2575:(8): 981–91.
2574:
2570:
2566:
2559:
2556:
2551:
2547:
2542:
2537:
2534:(3): 736–46.
2533:
2529:
2525:
2518:
2515:
2510:
2506:
2502:
2498:
2494:
2490:
2483:
2480:
2475:
2471:
2466:
2461:
2456:
2451:
2447:
2443:
2439:
2432:
2429:
2424:
2420:
2415:
2410:
2406:
2402:
2398:
2394:
2390:
2383:
2380:
2375:
2371:
2367:
2363:
2359:
2355:
2352:(1): 88–116.
2351:
2347:
2340:
2338:
2334:
2329:
2325:
2320:
2315:
2311:
2307:
2303:
2299:
2295:
2291:
2287:
2280:
2278:
2276:
2272:
2267:
2263:
2258:
2253:
2249:
2245:
2242:(1): 413–41.
2241:
2237:
2233:
2226:
2223:
2218:
2214:
2210:
2206:
2202:
2201:10.1038/ni857
2198:
2194:
2190:
2186:
2179:
2177:
2173:
2168:
2164:
2160:
2156:
2152:
2151:10.1038/ni858
2148:
2144:
2140:
2132:
2129:
2124:
2120:
2116:
2112:
2108:
2104:
2101:(5): 524–32.
2100:
2096:
2088:
2086:
2082:
2077:
2073:
2068:
2063:
2058:
2053:
2049:
2045:
2041:
2037:
2033:
2026:
2023:
2018:
2014:
2010:
2006:
2002:
2001:10.1038/87757
1998:
1995:(5): 443–51.
1994:
1990:
1983:
1980:
1975:
1971:
1967:
1963:
1959:
1955:
1951:
1947:
1940:
1937:
1932:
1928:
1924:
1920:
1916:
1912:
1905:
1902:
1897:
1893:
1888:
1883:
1879:
1875:
1871:
1864:
1862:
1858:
1853:
1849:
1845:
1841:
1837:
1833:
1830:(6): 455–60.
1829:
1825:
1818:
1815:
1810:
1806:
1802:
1798:
1794:
1790:
1783:
1780:
1775:
1771:
1766:
1761:
1757:
1753:
1749:
1745:
1741:
1734:
1731:
1726:
1722:
1716:
1713:
1708:
1704:
1698:
1695:
1691:
1687:
1682:
1680:
1678:
1674:
1670:
1666:
1661:
1659:
1657:
1653:
1647:
1643:
1640:
1638:
1635:
1633:
1630:
1628:
1625:
1624:
1620:
1618:
1611:
1609:
1605:
1603:
1598:
1594:
1590:
1586:
1578:
1576:
1572:
1570:
1566:
1561:
1557:
1555:
1551:
1544:
1542:
1540:
1535:
1528:
1526:
1524:
1519:
1517:
1509:
1507:
1504:
1495:
1493:
1491:
1487:
1483:
1475:
1473:
1471:
1467:
1459:
1457:
1454:
1449:
1445:
1441:
1437:
1433:
1429:
1425:
1421:
1417:
1413:
1409:
1401:
1399:
1397:
1393:
1389:
1385:
1381:
1377:
1373:
1369:
1365:
1361:
1357:
1353:
1345:
1343:
1341:
1337:
1336:
1331:
1330:
1325:
1321:
1313:
1311:
1308:
1305:
1301:
1296:
1289:NKG2D ligands
1288:
1286:
1284:
1280:
1276:
1272:
1268:
1264:
1260:
1256:
1252:
1248:
1244:
1239:
1237:
1233:
1229:
1225:
1221:
1216:
1208:
1206:
1204:
1200:
1196:
1192:
1188:
1184:
1180:
1176:
1175:NK1.1 T cells
1172:
1168:
1164:
1160:
1156:
1144:
1139:
1135:
1131:
1128:
1124:
1117:
1115:
1112:
1108:
1104:
1100:
1097:
1093:
1089:
1082:
1080:
1076:
1072:
1066:
1062:
1059:
1053:
1051:
1045:
1041:
1038:
1034:
1027:
1025:
1021:
1017:
1011:
1007:
1004:
998:
996:
990:
986:
983:
981:RefSeq (mRNA)
979:
972:
971:
966:
962:
959:
953:
952:
947:
943:
940:
938:
934:
927:
926:
921:
917:
914:
908:
907:
902:
898:
895:
893:
889:
882:
881:
876:
872:
869:
863:
862:
857:
853:
850:
848:
844:
841:
838:
836:
833:
829:
826:
822:
818:
811:
807:
802:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
697:
695:
692:
691:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
656:
654:
651:
650:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
610:
608:
605:
604:
601:
600:Gene ontology
597:
593:
581:
576:
573:
571:
567:
559:
554:
543:
539:
535:
531:
527:
523:
519:
515:
511:
507:
506:
503:
499:
494:
491:
481:
477:
473:
469:
465:
461:
457:
453:
449:
445:
444:
441:
437:
432:
429:
428:
425:
423:
419:
417:
416:
412:
411:
408:
406:
402:
398:
394:
390:
382:
377:
373:
369:
364:
354:
350:
343:
336:
330:
323:
315:
311:
307:
302:
298:
293:
289:
281:
276:
272:
268:
263:
253:
249:
242:
235:
229:
222:
218:
212:
208:
204:
199:
195:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
138:
133:
126:
121:
116:
105:
103:
99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
5685:
5342:
5262:
5240:
5218:
5065:
5028:
4991:
4944:
4914:
4887:
4709:
4615:
4463:
4192:
3944:
3752:
3748:
3738:
3703:
3699:
3654:(3): 422–8.
3651:
3647:
3637:
3602:
3598:
3588:
3561:
3557:
3520:(1): 55–63.
3517:
3513:
3503:
3476:
3472:
3462:
3429:
3425:
3419:
3392:
3388:
3378:
3333:
3329:
3319:
3286:
3282:
3276:
3251:
3247:
3241:
3208:
3204:
3198:
3171:
3167:
3157:
3122:
3118:
3070:
3066:
3056:
3043:
3008:
3004:
2966:10533/132162
2948:
2944:
2938:
2911:
2907:
2859:
2855:
2845:
2810:
2806:
2768:
2764:
2758:
2721:
2717:
2707:
2672:
2668:
2658:
2616:(2): e4503.
2613:
2609:
2599:
2572:
2568:
2558:
2531:
2527:
2517:
2495:(1): 39–85.
2492:
2488:
2482:
2445:
2441:
2431:
2396:
2392:
2382:
2349:
2345:
2293:
2289:
2239:
2235:
2225:
2192:
2188:
2142:
2138:
2131:
2098:
2094:
2039:
2035:
2025:
1992:
1988:
1982:
1949:
1945:
1939:
1914:
1910:
1904:
1880:(1): 19–29.
1877:
1873:
1827:
1823:
1817:
1795:(1): 16–25.
1792:
1788:
1782:
1747:
1743:
1733:
1724:
1715:
1706:
1697:
1642:Immunoevasin
1615:
1606:
1582:
1573:
1568:
1562:
1558:
1548:
1536:
1532:
1520:
1513:
1499:
1479:
1463:
1447:
1443:
1439:
1408:RNA splicing
1405:
1376:RAET1N/ULBP3
1372:RAET1L/ULBP6
1364:RAET1H/ULBP2
1360:RAET1G/ULBP5
1356:RAET1E/ULBP4
1351:
1349:
1339:
1333:
1328:
1323:
1319:
1317:
1309:
1292:
1285:signalling.
1240:
1212:
1181:, activated
1166:
1154:
1153:
1075:NP_001272947
1071:NP_001076791
1068:
1050:NP_001186734
1047:
1020:NM_001286018
1016:NM_001083322
1013:
992:
968:
949:
923:
904:
878:
859:
839:
834:
674:cell surface
420:
413:
379:129,600,827
366:129,587,286
140:External IDs
83:
3067:JCI Insight
1412:cell stress
1368:RAET1/ULBP1
1187:macrophages
540:granulocyte
512:gallbladder
478:bone marrow
466:gallbladder
446:granulocyte
278:10,391,874
265:10,372,353
118:Identifiers
5847:Immunology
5831:Categories
3827:(see also
3599:Immunology
2399:: 101072.
1692:, May 2017
1671:, May 2017
1648:References
1602:γδ T cells
1352:RAET1/ULBP
1314:MIC family
1275:ITAM motif
1195:γδ T cells
1179:γδ T cells
1161:family of
454:lymph node
424:(ortholog)
161:HomoloGene
5842:Receptors
3125:: 55–61.
2983:205150174
2374:205213312
1627:CD94/NKG2
1597:cytokines
1523:senolytic
1466:infection
1416:infection
1209:Structure
1079:NP_149069
1024:NM_033078
995:NM_007360
825:Orthologs
169:GeneCards
3821:Proteins
3781:29568297
3730:19631564
3700:Immunity
3678:22366950
3629:26661515
3580:23804716
3536:20511557
3495:28378389
3454:35460567
3446:11224526
3411:19542445
3370:10359807
3311:13356420
3303:17952078
3268:16551250
3233:20895192
3225:16470377
3190:17717540
3149:29525346
3097:31184599
3035:26878797
2975:20714339
2930:31720075
2886:20718868
2878:12594848
2837:21898152
2785:18602338
2750:29662484
2699:24718859
2650:19223974
2610:PLOS ONE
2591:18544572
2550:27342847
2509:15189136
2474:24432022
2423:32298812
2366:26284473
2328:15995699
2266:23298206
2209:12426564
2167:14901451
2159:12426565
2123:28236529
2115:16582911
2076:15894612
2017:11096566
2009:11323699
1974:18234848
1966:14523385
1931:10426993
1896:12150888
1874:Immunity
1852:27350036
1789:Genomics
1688:–
1667:–
1621:See also
1550:NK cells
1460:Function
1191:NK cells
1171:NK cells
1127:Wikidata
804:Sources:
664:membrane
482:testicle
462:appendix
5629:301–350
5423:251–300
5375:CD240CE
5172:201–250
4856:151–200
4579:101–150
3772:5852076
3755:: 441.
3721:2782462
3669:3436127
3620:4754608
3338:Bibcode
3140:6145810
3088:6675550
3026:4789586
2921:6834480
2828:3192283
2741:5890157
2724:: 476.
2690:3998197
2641:2637608
2618:Bibcode
2465:3882864
2448:: 508.
2414:7263313
2319:1352168
2298:Bibcode
2257:4244079
2217:5859797
2067:1140444
2044:Bibcode
1911:Science
1844:8436421
1809:9177771
1774:2007850
1765:2190798
1690:Ensembl
1669:Ensembl
1591:(TCR),
1585:T cells
1222:dimer.
937:UniProt
892:Ensembl
831:Species
810:QuickGO
399:pattern
257:12p13.2
157:1196250
125:Aliases
5636:CD300A
5595:CDw293
5380:CD240D
5241:CD213a
5219:CDw210
5184:CD202b
5158:CDw199
5153:CDw198
4807:CD140b
4239:51–100
3779:
3769:
3728:
3718:
3676:
3666:
3627:
3617:
3578:
3534:
3493:
3452:
3444:
3409:
3368:
3358:
3309:
3301:
3266:
3231:
3223:
3188:
3147:
3137:
3095:
3085:
3033:
3023:
2981:
2973:
2928:
2918:
2884:
2876:
2835:
2825:
2783:
2748:
2738:
2697:
2687:
2648:
2638:
2589:
2548:
2507:
2472:
2462:
2421:
2411:
2372:
2364:
2326:
2316:
2290:Nature
2264:
2254:
2215:
2207:
2165:
2157:
2121:
2113:
2074:
2064:
2015:
2007:
1972:
1964:
1929:
1894:
1850:
1842:
1807:
1772:
1762:
1470:cancer
1388:MULT-1
1386:, and
1324:MICA-G
1318:Human
1273:bears
1113:search
1111:PubMed
970:O54709
951:P26718
847:Entrez
570:BioGPS
528:spleen
524:morula
450:spleen
165:136440
149:611817
5816:CD350
5811:CD349
5806:CD344
5801:CD340
5796:CD339
5791:CD338
5786:CD337
5781:CD336
5776:CD335
5771:CD334
5766:CD333
5761:CD332
5756:CD331
5751:CD329
5746:CD328
5741:CD327
5736:CD326
5731:CD325
5726:CD324
5721:CD322
5716:CD321
5711:CD320
5706:CD318
5701:CD317
5696:CD316
5691:CD315
5686:CD314
5681:CD312
5676:CD309
5671:CD307
5666:CD306
5661:CD305
5656:CD304
5651:CD303
5646:CD302
5641:CD301
5620:CD299
5615:CD298
5610:CD297
5605:CD295
5600:CD294
5590:CD292
5585:CD290
5580:CD289
5575:CD288
5570:CD286
5565:CD284
5560:CD283
5555:CD282
5550:CD281
5545:CD280
5540:CD279
5535:CD278
5530:CD276
5525:CD275
5520:CD274
5515:CD273
5510:CD272
5505:CD271
5500:CD269
5495:CD268
5490:CD267
5485:CD266
5480:CD265
5475:CD264
5470:CD263
5465:CD262
5460:CD261
5455:CD258
5450:CD257
5445:CD256
5440:CD254
5435:CD253
5430:CD252
5414:CD249
5409:CD248
5405:CD247
5400:CD246
5395:CD244
5390:CD243
5385:CD241
5370:CD239
5365:CD238
5360:CD236
5343:CD235
5338:CD234
5333:CD233
5328:CD230
5323:CD229
5318:CD228
5313:CD227
5308:CD226
5303:CD225
5298:CD224
5293:CD223
5288:CD222
5283:CD221
5278:CD220
5263:CD218
5258:CD217
5236:CD212
5214:CD209
5209:CD208
5204:CD207
5199:CD206
5194:CD205
5189:CD204
5179:CD201
5163:CD200
5148:CD197
5143:CD196
5138:CD195
5133:CD194
5128:CD193
5123:CD192
5118:CD191
5113:CD186
5108:CD185
5103:CD184
5098:CD183
5093:CD182
5088:CD181
5083:CD180
5066:CD179
5061:CD178
5056:CD177
5051:CD174
5029:CD172
5024:CD171
5019:CD170
5014:CD169
5009:CD168
4992:CD167
4987:CD166
4982:CD164
4977:CD163
4972:CD162
4967:CD161
4962:CD160
4945:CD159
4915:CD158
4910:CD157
4888:CD156
4883:CD155
4878:CD154
4873:CD153
4868:CD152
4863:CD151
4847:CD150
4842:CD148
4837:CD147
4832:CD146
4827:CD144
4822:CD143
4817:CD142
4812:CD141
4802:CD138
4797:CD137
4792:CD136
4787:CD135
4782:CD134
4777:CD133
4772:CD132
4767:CD131
4762:CD130
4757:CD129
4752:CD127
4747:CD126
4742:CD125
4737:CD124
4732:CD123
4727:CD122
4710:CD121
4693:CD120
4688:CD119
4683:CD118
4678:CD117
4673:CD116
4668:CD115
4663:CD114
4658:CD113
4653:CD112
4648:CD111
4643:CD110
4638:CD109
4633:CD108
4616:CD107
4611:CD106
4606:CD105
4601:CD104
4596:CD103
4591:CD102
4586:CD101
4570:CD100
3450:S2CID
3361:22010
3307:S2CID
3229:S2CID
3005:Aging
2979:S2CID
2882:S2CID
2370:S2CID
2213:S2CID
2163:S2CID
2119:S2CID
2013:S2CID
1970:S2CID
1848:S2CID
1569:Klrk1
1448:Reat1
1446:s or
1392:ULBP2
1380:Rae-1
1283:Zap70
1271:DAP12
1255:DAP10
1251:DAP12
1247:DAP10
1243:DAP10
1224:DAP10
1220:DAP10
1215:DAP10
1167:KLRK1
1155:NKG2D
880:27007
861:22914
840:Mouse
835:Human
806:Amigo
458:blood
422:Mouse
415:Human
362:Start
297:Mouse
261:Start
194:Human
173:KLRK1
132:KLRK1
33:KLRK1
18:KLRK1
4565:CD99
4560:CD98
4555:CD97
4550:CD96
4545:CD95
4540:CD94
4535:CD93
4530:CD92
4526:CD91
4521:CD90
4516:CD89
4511:CD88
4506:CD87
4501:CD86
4464:CD85
4459:CD84
4454:CD83
4449:CD82
4444:CD81
4439:CD80
4422:CD79
4417:CD78
4412:CD74
4407:CD73
4402:CD72
4397:CD71
4392:CD70
4387:CD69
4382:CD68
4345:CD66
4323:CD64
4318:CD63
4296:CD62
4291:CD61
4286:CD59
4281:CD58
4276:CD57
4271:CD56
4266:CD55
4261:CD54
4256:CD53
4251:CD52
4246:CD51
4230:CD50
4193:CD49
4188:CD48
4183:CD47
4178:CD46
4173:CD45
4168:CD44
4163:CD43
4136:CD42
4131:CD41
4126:CD40
4121:CD39
4116:CD38
4111:CD37
4106:CD36
4101:CD35
4096:CD34
4091:CD33
4074:CD32
4069:CD31
4064:CD30
4059:CD29
4054:CD28
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