1489:
subpopulations, and alter kalirin activity within neurons. During early development, the long kalirin9 and 12 isoforms are predominant in the brain. These isoforms contain both a Rac and a RhoA selective GEF domain, and control axonal growth and dendritic branching. Kalirin9 and 12 are also expressed ubiquitously throughout the body and have functions outside the brain. However, during neurodevelopment, the kalirin7 isoform is preferentially expressed during periods of synaptogenesis, and this isoform displays highly restricted cortical expression. Kalirin7 expresses only the N-terminal domains, including the Rac-GEF domain along with a c-terminal PDZ-binding domain that strongly targets kalirin7 to the post-synaptic density. It is likely this subcellular distribution is vital to kalirin7 function, as this isoform exerts control dendritic spine density and synaptic plasticity. It is likely that mutations that result in deregulation of kalirin function within the brain is responsible for the role of kalirin within multiple neurological disorders.
1450:
and likely affects the function of kalirin9 and 12 isoforms early in neuronal development. A patient harboring a homozygous mutation in kalirin's spectrin repeat domain was found to have severe intellectual disability, and both truncating and missense mutations have been identified in patients with developmental delay. Several intronic variants have been associated with addiction and were found to alter the function of brain regions responsible for reward anticipation. This link to addiction is supported by animal models, where loss of kalirin results in altered cocaine self-administration and synaptic and expression changes in response to cocaine. Perhaps the most compelling genetic links are between kalirin and schizophrenia. Numerous missense mutations in KALRN have been identified in exome sequencing studies of schizophrenia cohorts that are predicted to be deleterious to protein function.
297:
274:
1476:
ability to regulate RAC-PAK signaling and actin dynamics, which in turn can regulate the size and density of dendritic spines. Within dendritic spines, kalirin interacts with multiple disease-related proteins to regulate synapse strength. It directly interacts with the schizophrenia risk factor DISC1 that can act to suppress kalirin function within the spine. Furthermore, kalirin7 directly interacts with the GluN2B subunit of the NMDA receptor and PSD95 within the post-synaptic density.
171:
196:
1480:
in prepulse inhibition, sociability and increased locomotor activity. Notably, loss of kalirin results in deficits in working memory, but not reference memory. The generation of a kalirin7 specific knockout animal model revealed similar deficits in spine density, suggesting a central role of kalirin7 in regulating neuronal connectivity. Both full and kalirin7 specific knockout animals show decreased anxiety-like behavior and impaired contextual fear learning.
303:
202:
1472:
been attributed to Rac-PAK pathway activation. kalirin has found been found to exert control over dendritic arborization, axonal growth, dendritic spine formation and synaptic activity and plasticity. These effects are regulated by protein-protein interactions and post-translational modifications within the non-catalytic domains, and have been shown to exert control over kalirin subcellular targeting and activation.
6324:
1505:
1449:
Several mutations within KALRN have been linked to neurological disease. In autism spectrum disorder, a frameshift mutation was found that is likely to lead to transcript decay, and heterozygosity. Another, found within the second GEF domain, is predicted to be highly deleterious to RhoA-GEF activity
1479:
The importance of KALRN in neurodevelopment is supported by knockout animal models that display profound deficiencies in multiple behavioral tasks. Kalirin knockout animals display reduced GEF activity, dendritic arborization and spine density. These deficits may be linked to the observed reductions
1471:
The majority of kalirin's effects are induced through its catalytic GEF domain signaling. By promoting the release of GDP from Rac and RhoA, it acts as an activator of GTPase signaling within the cell. Although able to activate Rac and RhoA, much of its activity in regulating neuronal morphology has
1462:
In addition to neurodevelopmental disorders, kalirin has been found to be underexpressed in the post-mortem
Alzheimer's brain. This loss of kalirin expression was recapitulated in animal models of Alzheimer's disease. Moreover, introduction of kalirin7 into culture or animal models of Alzheimer's
1453:
Neuronal studies have provided insight into the mechanisms of some missense mutations, particularly within the GEF domains of KALRN. A mutation found within the Rac-GEF domain was found to induce strong reductions in Rac activation, neuronal branching, and spine density. These effects were mirrored
1475:
Kalirin has been found to play a critical role in synaptic activity and plasticity. Loss of KALRN results in decreased nMDAr and AMPAr-mediated mEPSC, and kalirin7 knockout animals show strong deficits in NMDAr mediated long-term potentiation and long term depression. This may be linked to the
1488:
Multiple isoforms, arising from alternate splicing and promoter usage, display varying tissue and developmental expression. Control over kalirin expression is exerted through the use of alternate promoters which produce alternate start sites and restrict expression to specific neuronal
50:
6349:
6354:
1458:
RhoA-GEF activity. In addition to exome sequencing, post-mortem studies have consistently found alterations in kalirin transcript levels within the brain further supporting a role for kalirin in the etiology of schizophrenia.
4187:
2116:
Youn H, Ji I, Ji HP, Markesbery WR, Ji TH (November 2007). "Under-expression of
Kalirin-7 Increases iNOS activity in cultured cells and correlates to elevated iNOS activity in Alzheimer's disease hippocampus".
4472:
1411:
for its ability to interact with numerous other proteins. Kalirin's other name, DUO, comes from the fact that it is 98% identical to rat DUO protein and 80.6% identical to a human protein named
4180:
1463:
disease was able to rescue synaptic and behavioral deficits, suggesting an important role for kalirin in regulating synapse loss and cognitive impairment in
Alzheimer's disease.
2382:
4173:
4380:
310:
209:
1446:
The KALRN gene, has been linked to multiple neurological disorders both through large exome and genome sequencing efforts, as well as post mortem and clinical studies.
4928:
5767:
4231:
3865:"Isoforms of kalirin, a neuronal Dbl family member, generated through use of different 5'- and 3'-ends along with an internal translational initiation site"
5876:
2229:"Faculty Opinions recommendation of Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism"
2192:"Faculty Opinions recommendation of Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism"
4614:
4501:
937:
132:
4889:
918:
5862:
5327:
4218:
4200:
6364:
5964:
5845:
1720:
Kawai T, Sanjo H, Akira S (February 1999). "Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and
Pleckstrin-Homology (PH) domains".
5551:
4420:
2333:"Exome sequencing discloses KALRN homozygous variant as likely cause of intellectual disability and short stature in a consanguineous pedigree"
1658:
5615:
4590:
4054:"Kalirin, a GDP/GTP exchange factor of the Dbl family, is localized to nerve, muscle, and endocrine tissue during embryonic rat development"
1640:
6344:
5871:
2913:"The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model"
2873:"Faculty Opinions recommendation of Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies"
296:
4405:
2155:
Youn H, Jeoung M, Koo Y, Ji H, Markesbery WR, Ji I, Ji TH (June 2007). "Kalirin is under-expressed in
Alzheimer's disease hippocampus".
1305:
5928:
5603:
4159:
1401:
1312:
273:
6043:
4860:
4850:
4535:
3014:"Distinct roles for the two Rho GDP/GTP exchange factor domains of kalirin in regulation of neurite growth and neuronal morphology"
2532:"Correction: Wang et al., Kalirin-7 Mediates Cocaine-Induced AMPA Receptor and Spine Plasticity, Enabling Incentive Sensitization"
5542:
2433:"Mouse and Human Genetic Analyses Associate Kalirin with Ventral Striatal Activation during Impulsivity and with Alcohol Misuse"
1681:"Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain"
5811:
5483:
4845:
4836:
1627:
1606:
1391:
1525:
Euan
Parnell; Lauren P Shapiro; Roos Voorn; Marc P Forrest; Hiba A Jalloul; Daniel D Loizzo; Peter Penzes (12 November 2020).
3175:"Kalirin Dbl-homology guanine nucleotide exchange factor 1 domain initiates new axon outgrowths via RhoG-mediated mechanisms"
6199:
1623:
3912:
McPherson CE, Eipper BA, Mains RE (February 2002). "Genomic organization and differential expression of
Kalirin isoforms".
2726:"Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility"
1804:
McPherson CE, Eipper BA, Mains RE (February 2002). "Genomic organization and differential expression of
Kalirin isoforms".
195:
170:
47:
5226:
4723:
4714:
4371:
4317:
4000:"An N-terminal Amphipathic Helix Binds Phosphoinositides and Enhances Kalirin Sec14 Domain-mediated Membrane Interactions"
2824:"Molecular mechanisms contributing to dendritic spine alterations in the prefrontal cortex of subjects with schizophrenia"
6314:
1602:
4414:
112:
1512:
The 2020 version of this article was updated by an external expert under a dual publication model. The corresponding
309:
208:
4165:
3612:"The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis"
5438:
5256:
4752:
6184:
302:
201:
6300:
6287:
6274:
6261:
6248:
6235:
6222:
5428:
5423:
5418:
5408:
5403:
5398:
5388:
5183:
4958:
4554:
6194:
6148:
6091:
5651:
5642:
5593:
4359:
4204:
982:
120:
6096:
5951:
5374:
963:
2431:
Peña-Oliver Y, Carvalho FM, Sanchez-Roige S, Quinlan EB, Jia T, Walker-Tilley T, et al. (2016-04-07).
3509:"Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action"
2669:"A sequence variant in human KALRN impairs protein function and coincides with reduced cortical thickness"
1440:
3458:"Using Kalirin conditional knockout mice to distinguish its role in dopamine receptor mediated behaviors"
6117:
6036:
4650:
1513:
1398:
6189:
1415:. Unlike TRIO, which is expressed in numerous tissues, Kalirin isoforms are mainly found in the brain.
3409:"Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function"
5217:
3302:
3078:
2680:
2640:"Faculty Opinions recommendation of A polygenic burden of rare disruptive mutations in schizophrenia"
2277:
2067:
1439:, as demonstrated by adolescent development of schizophrenia-like symptoms in kalirin knockout mice.
1428:
184:
3558:
Hayashi-Takagi A, Takaki M, Graziane N, Seshadri S, Murdoch H, Dunlop AJ, et al. (March 2010).
99:
6153:
3067:"Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling"
1432:
1284:
1255:
1251:
1247:
1243:
1239:
1235:
1231:
1227:
1223:
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1201:
1197:
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1132:
1128:
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1120:
1116:
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1100:
1096:
1092:
1088:
1084:
1080:
1076:
1072:
1062:
1058:
1046:
5725:
3713:"Long-term perturbation of spine plasticity results in distinct impairments of cognitive function"
6359:
6086:
5828:
5782:
4083:
3894:
3641:
3214:
2890:
2853:
2571:
2413:
2313:
2246:
2209:
144:
3610:
Penzes P, Johnson RC, Sattler R, Zhang X, Huganir RL, Kambampati V, et al. (January 2001).
3237:"Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines"
1841:"Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines"
1288:
1263:
1259:
1173:
1054:
1050:
3235:
Xie Z, Srivastava DP, Photowala H, Kai L, Cahill ME, Woolfrey KM, et al. (November 2007).
1839:
Xie Z, Srivastava DP, Photowala H, Kai L, Cahill ME, Woolfrey KM, et al. (November 2007).
1679:
Colomer V, Engelender S, Sharp AH, Duan K, Cooper JK, Lanahan A, et al. (September 1997).
5088:
4797:
4134:
4075:
4031:
3980:
3929:
3886:
3845:
3794:
3742:
3690:
3633:
3589:
3540:
3489:
3438:
3384:
3330:
3266:
3206:
3155:
3106:
3043:
2991:
2942:
2845:
2804:
2755:
2706:
2667:
Russell TA, Blizinsky KD, Cobia DJ, Cahill ME, Xie Z, Sweet RA, et al. (September 2014).
2620:
2553:
2513:
2482:
Kiraly DD, Nemirovsky NE, LaRese TP, Tomek SE, Yahn SL, Olive MF, et al. (October 2013).
2464:
2405:
2364:
2305:
2172:
2134:
2095:
2023:
1971:
1922:
1870:
1821:
1786:
1737:
1702:
1562:
1544:
103:, ARHGEF24, CHD5, CHDS5, DUET, DUO, HAPIP, TRAD, kalirin, RhoGEF kinase, kalirin RhoGEF kinase
92:
40:
2264:
Leblond CS, Cliquet F, Carton C, Huguet G, Mathieu A, Kergrohen T, et al. (2018-07-06).
6132:
6127:
6101:
6029:
5681:
4923:
4913:
4908:
4826:
4817:
4747:
4738:
4684:
4675:
4332:
4124:
4114:
4065:
4021:
4011:
3970:
3960:
3921:
3876:
3835:
3825:
3784:
3776:
3732:
3724:
3680:
3672:
3623:
3579:
3571:
3530:
3520:
3479:
3469:
3428:
3420:
3374:
3364:
3320:
3310:
3291:"Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP"
3256:
3248:
3196:
3186:
3145:
3137:
3096:
3086:
3033:
3025:
2981:
2973:
2932:
2924:
2880:
2835:
2794:
2786:
2745:
2737:
2696:
2688:
2647:
2610:
2602:
2561:
2543:
2503:
2495:
2484:"Constitutive knockout of kalirin-7 leads to increased rates of cocaine self-administration"
2454:
2444:
2397:
2354:
2344:
2331:
Makrythanasis P, Guipponi M, Santoni FA, Zaki M, Issa MY, Ansar M, et al. (July 2016).
2295:
2287:
2236:
2199:
2164:
2126:
2085:
2075:
2013:
2005:
1961:
1953:
1912:
1904:
1860:
1852:
1813:
1776:
1768:
1729:
1692:
1570:
1552:
1536:
389:
320:
264:
219:
3763:
Xie Z, Cahill ME, Radulovic J, Wang J, Campbell SL, Miller CA, et al. (January 2011).
2773:
Narayan S, Tang B, Head SR, Gilmartin TJ, Sutcliffe JG, Dean B, Thomas EA (November 2008).
140:
6179:
6163:
6076:
5507:
4578:
4573:
4568:
2056:"Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes"
2054:
Cahill ME, Xie Z, Day M, Photowala H, Barbolina MV, Miller CA, et al. (August 2009).
364:
3560:"Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1"
2962:"Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers"
3306:
3082:
2911:
Cissé M, Duplan E, Lorivel T, Dunys J, Bauer C, Meckler X, et al. (November 2017).
2684:
2071:
6328:
6217:
6158:
4129:
4102:
4026:
3999:
3975:
3948:
3840:
3813:
3789:
3764:
3737:
3712:
3685:
3660:
3584:
3559:
3535:
3508:
3484:
3457:
3433:
3408:
3379:
3352:
3325:
3290:
3261:
3236:
3201:
3191:
3174:
3150:
3125:
3101:
3066:
3038:
3029:
3013:
2986:
2961:
2937:
2912:
2799:
2774:
2750:
2725:
2701:
2668:
2615:
2590:
2566:
2531:
2508:
2483:
2459:
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2359:
2332:
2300:
2265:
2090:
2055:
2018:
1993:
1966:
1941:
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1892:
1865:
1840:
1781:
1756:
1557:
1531:
1526:
3925:
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852:
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827:
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6338:
6122:
6081:
4631:
4563:
3812:
Mandela P, Yankova M, Conti LH, Ma XM, Grady J, Eipper BA, Mains RE (November 2012).
3728:
3351:
Lemtiri-Chlieh F, Zhao L, Kiraly DD, Eipper BA, Mains RE, Levine ES (December 2011).
2575:
2317:
2250:
2213:
1772:
1755:
Chakrabarti K, Lin R, Schiller NI, Wang Y, Koubi D, Fan YX, et al. (June 2005).
1436:
567:
4087:
3218:
3126:"Kalirin-9 and Kalirin-12 Play Essential Roles in Dendritic Outgrowth and Branching"
2894:
2724:
Kushima I, Nakamura Y, Aleksic B, Ikeda M, Ito Y, Shiino T, et al. (May 2012).
2417:
1891:
Ma XM, Kiraly DD, Gaier ED, Wang Y, Kim EJ, Levine ES, et al. (November 2008).
124:
6071:
5502:
4327:
3898:
3645:
3507:
Paskus JD, Tian C, Fingleton E, Shen C, Chen X, Li Y, et al. (December 2019).
3424:
2960:
Xie Z, Shapiro LP, Cahill ME, Russell TA, Lacor PN, Klein WL, Penzes P (May 2019).
2790:
2606:
2548:
1957:
1908:
382:
161:
2885:
2872:
2857:
2652:
2639:
2241:
2228:
2204:
2191:
1394:. Is also known to play an important role in nerve growth and axonal development.
3949:"Kalrn promoter usage and isoform expression respond to chronic cocaine exposure"
3525:
3252:
2401:
2266:"Both rare and common genetic variants contribute to autism in the Faroe Islands"
1856:
1454:
by mutations in the RhoA-GEF domain, producing similar neuronal deficits, but by
148:
6295:
6230:
6066:
5708:
5340:
5280:
5163:
5083:
4807:
1663:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1645:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1435:
in mature cortical neurons and is thought to be important in the development of
1412:
6323:
4070:
4053:
3353:"Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity"
3295:
Proceedings of the National Academy of Sciences of the United States of America
3071:
Proceedings of the National Academy of Sciences of the United States of America
2775:"Molecular profiles of schizophrenia in the CNS at different stages of illness"
2060:
Proceedings of the National Academy of Sciences of the United States of America
2009:
1540:
465:
5796:
4270:
3780:
3676:
3474:
3062:
2349:
2291:
281:
178:
128:
4103:"Kalirin, a key player in synapse formation, is implicated in human diseases"
3830:
3369:
2557:
2449:
2409:
2383:"Prevalence and Architecture of De Novo Mutations in Developmental Disorders"
1548:
1408:
6269:
6243:
4757:
4154:
4016:
3965:
3315:
3141:
3091:
2741:
2080:
1574:
882:
525:
403:
348:
335:
247:
234:
136:
6350:
Knowledge (XXG) articles with corresponding academic peer reviewed articles
4138:
4079:
4035:
3984:
3933:
3890:
3881:
3864:
3849:
3798:
3746:
3694:
3637:
3593:
3544:
3493:
3442:
3407:
Kiraly DD, Lemtiri-Chlieh F, Levine ES, Mains RE, Eipper BA (August 2011).
3388:
3334:
3270:
3210:
3159:
3110:
3047:
2995:
2946:
2849:
2808:
2759:
2710:
2624:
2517:
2499:
2468:
2368:
2309:
2176:
2168:
2138:
2130:
2099:
2027:
1975:
1926:
1874:
1825:
1790:
1741:
1697:
1680:
1566:
4119:
2840:
2823:
1706:
1352:
1347:
5113:
5008:
5003:
4998:
3012:
Penzes P, Johnson RC, Kambampati V, Mains RE, Eipper BA (November 2001).
1757:"Critical role for Kalirin in nerve growth factor signaling through TrkA"
1504:
1336:
1027:
1008:
3947:
Mains RE, Kiraly DD, Eipper-Mains JE, Ma XM, Eipper BA (February 2011).
2928:
2589:
Kiraly DD, Ma XM, Mazzone CM, Xin X, Mains RE, Eipper BA (August 2010).
1377:
serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
5772:
5750:
5745:
5735:
5730:
5532:
5527:
5522:
5517:
5512:
5497:
5492:
5108:
4347:
4342:
4337:
2692:
1424:
1380:
994:
949:
6355:
Knowledge (XXG) articles with corresponding articles published in Gene
2977:
69:
6282:
6052:
6002:
5997:
5992:
5987:
5982:
5977:
5972:
5923:
5918:
5913:
5908:
5903:
5886:
5881:
5755:
5740:
5691:
5686:
5671:
5666:
5661:
5656:
5630:
5625:
5620:
5608:
5586:
5581:
5473:
5448:
5123:
4948:
4943:
4938:
4933:
4918:
4762:
4699:
4694:
4689:
4665:
4491:
4486:
4460:
4455:
4450:
4440:
4435:
4425:
4265:
4196:
1390:. Kalirin was first identified in 1997 as a protein interacting with
1320:
904:
3575:
2591:"Behavioral and morphological responses to cocaine require kalirin7"
1527:"KALRN: a central regulator of synaptic function and synaptopathies"
1431:. One of the isoforms, Kalirin-7, was found to be necessary for the
2282:
6256:
5898:
5891:
5801:
5698:
5598:
5576:
5571:
5566:
5561:
5556:
5468:
5463:
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5393:
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5168:
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5138:
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5103:
5098:
5093:
5073:
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5058:
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5023:
5018:
5013:
4993:
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4903:
4898:
4792:
4787:
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4772:
4767:
4728:
4660:
4655:
4604:
4599:
4525:
4520:
4515:
4481:
4473:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
4275:
4260:
4255:
4250:
4245:
4240:
867:
863:
5791:
5718:
5713:
5703:
5676:
5433:
5383:
5364:
5359:
5354:
5349:
5304:
5299:
5294:
5289:
5236:
5192:
5133:
5128:
5078:
5063:
5033:
4963:
4879:
4874:
4869:
4802:
4704:
4645:
4640:
4544:
4510:
4395:
4390:
4385:
4354:
4322:
4310:
4305:
4300:
4290:
4285:
3814:"Kalrn plays key roles within and outside of the nervous system"
1387:
116:
6025:
5949:
5325:
4216:
4169:
5760:
4295:
4280:
4160:
Architect of Synaptic Plasticity Links Spine Form and Function
1498:
3661:"Kalirin loss results in cortical morphological alterations"
4052:
Hansel DE, Quiñones ME, Ronnett GV, Eipper BA (July 2001).
3998:
Miller MB, Vishwanatha KS, Mains RE, Eipper BA (May 2015).
1893:"Kalirin-7 is required for synaptic structure and function"
1397:
Kalirin is a member of the Dbl family of proteins and is a
6021:
3346:
3344:
372:
3863:
Johnson RC, Penzes P, Eipper BA, Mains RE (June 2000).
3173:
May V, Schiller MR, Eipper BA, Mains RE (August 2002).
723:
regulation of small GTPase mediated signal transduction
848:
positive regulation of long-term synaptic potentiation
6312:
758:
regulation of protein localization to plasma membrane
537:
1994:"Dendritic spine dynamics--a key role for kalirin-7"
1407:
It is named after the multiple-handed Hindu goddess
738:
positive regulation of dendritic spine morphogenesis
6208:
6172:
6141:
6110:
6059:
5963:
5861:
5844:
5827:
5810:
5781:
5641:
5541:
5482:
5373:
5339:
5279:
5255:
5216:
5182:
4888:
4859:
4835:
4816:
4737:
4713:
4674:
4630:
4613:
4589:
4553:
4534:
4500:
4471:
4404:
4370:
4230:
1277:
1192:
1162:
1045:
508:
dentate gyrus of hippocampal formation granule cell
4155:Traffic jam in brain causes schizophrenia symptoms
3765:"Hippocampal phenotypes in kalirin-deficient mice"
3706:
3704:
3456:LaRese TP, Yan Y, Eipper BA, Mains RE (May 2017).
1942:"Kalirin-7: linking spine plasticity and behavior"
1619:
1617:
1615:
1598:
1596:
1594:
778:positive regulation of dendritic spine development
768:regulation of synaptic transmission, glutamatergic
1369:Huntingtin-associated protein-interacting protein
319:
218:
3605:
3603:
3061:Jones KA, Srivastava DP, Allen JA, Strachan RT,
1987:
1985:
4058:The Journal of Histochemistry and Cytochemistry
3284:
3282:
3280:
2150:
2148:
2111:
2109:
2049:
2047:
2045:
2043:
2041:
2039:
2037:
1886:
1884:
833:negative regulation of growth hormone secretion
16:Protein-coding gene in the species Homo sapiens
4047:
4045:
3402:
3400:
3398:
3007:
3005:
1624:GRCm38: Ensembl release 89: ENSMUSG00000061751
6037:
4232:Non-specific serine/threonine protein kinases
4181:
2906:
2904:
1674:
1672:
718:regulation of Rho protein signal transduction
8:
2822:Hill JJ, Hashimoto T, Lewis DA (June 2006).
853:G protein-coupled receptor signaling pathway
843:behavioral response to formalin induced pain
3758:
3756:
3659:Xie Z, Cahill ME, Penzes P (January 2010).
3230:
3228:
3124:Yan Y, Eipper BA, Mains RE (October 2015).
1603:GRCh38: Ensembl release 89: ENSG00000160145
6044:
6030:
6022:
5960:
5946:
5336:
5322:
4615:Goodpasture-antigen-binding protein kinase
4227:
4213:
4188:
4174:
4166:
4162:- Schizophrenia Research Forum, 2007-11-30
1189:
1042:
878:
823:regulation of neuronal synaptic plasticity
596:guanyl-nucleotide exchange factor activity
563:
360:
259:
156:
58:
5328:Serine/threonine-specific protein kinases
4502:(isocitrate dehydrogenase (NADP+)) kinase
4219:Serine/threonine-specific protein kinases
4201:Serine/threonine-specific protein kinases
4128:
4118:
4069:
4025:
4015:
3974:
3964:
3880:
3839:
3829:
3788:
3736:
3711:Vanleeuwen JE, Penzes P (December 2012).
3684:
3627:
3583:
3534:
3524:
3483:
3473:
3432:
3378:
3368:
3324:
3314:
3260:
3200:
3190:
3149:
3100:
3090:
3037:
2985:
2936:
2884:
2839:
2798:
2749:
2700:
2651:
2614:
2565:
2547:
2507:
2458:
2448:
2358:
2348:
2299:
2281:
2240:
2203:
2089:
2079:
2017:
1965:
1916:
1864:
1780:
1696:
1556:
5863:Receptor protein serine/threonine kinase
838:maternal process involved in parturition
713:positive regulation of apoptotic process
611:protein serine/threonine kinase activity
6319:
5846:Low-density-lipoprotein receptor kinase
3289:Herring BE, Nicoll RA (February 2016).
1590:
2390:Obstetrical & Gynecological Survey
763:positive regulation of GTPase activity
18:
4591:Fas-activated serine/threonine kinase
324:
285:
280:
223:
182:
177:
7:
5872:Bone morphogenetic protein receptors
3769:Molecular and Cellular Neurosciences
3665:Molecular and Cellular Neurosciences
2966:The European Journal of Neuroscience
1940:Sommer JE, Budreck EC (April 2009).
4406:Dephospho-(reductase kinase) kinase
4004:The Journal of Biological Chemistry
3869:The Journal of Biological Chemistry
1535:. Gene Wiki Review Series: 145306.
4861:G-protein coupled receptor kinases
3192:10.1523/jneurosci.22-16-06980.2002
3030:10.1523/jneurosci.21-21-08426.2001
1992:Penzes P, Jones KA (August 2008).
1402:guanine nucleotide exchange factor
1274:
1159:
1018:
999:
973:
954:
928:
909:
788:neuromuscular junction development
542:
460:
398:
377:
14:
4851:Beta adrenergic receptor kinase-2
4536:(tyrosine 3-monooxygenase) kinase
1443:may also be linked to kalirin-7.
1383:that in humans is encoded by the
698:ephrin receptor signaling pathway
688:intracellular signal transduction
6322:
5543:Mitogen-activated protein kinase
3729:10.1111/j.1471-4159.2012.07899.x
2871:Nairn A, Leslie S (2018-12-19).
1773:10.1128/MCB.25.12.5106-5118.2005
1503:
1427:of Kalirin are produced through
828:smooth muscle cell proliferation
308:
301:
295:
272:
207:
200:
194:
169:
5929:Anti-Müllerian hormone receptor
5812:(acetyl-CoA carboxylase) kinase
5484:(RNA-polymerase)-subunit kinase
4846:Beta adrenergic receptor kinase
4837:Beta adrenergic receptor kinase
1392:huntingtin-associated protein 1
803:response to mechanical stimulus
783:Rho protein signal transduction
6365:GTP-binding protein regulators
5552:Extracellular signal-regulated
3425:10.1523/jneurosci.3143-11.2011
2791:10.1016/j.brainres.2008.08.023
2607:10.1016/j.biopsych.2010.03.024
2549:10.1523/jneurosci.4822-13.2014
2157:Journal of Alzheimer's Disease
2119:Journal of Alzheimer's Disease
1958:10.1523/JNEUROSCI.0235-09.2009
1909:10.1523/JNEUROSCI.4269-08.2008
1761:Molecular and Cellular Biology
743:behavioral response to cocaine
526:More reference expression data
504:Region I of hippocampus proper
438:dorsolateral prefrontal cortex
1:
5616:P38 mitogen-activated protein
4715:cGMP-dependent protein kinase
4676:cAMP-dependent protein kinase
4372:Pyruvate dehydrogenase kinase
4318:Ataxia telangiectasia mutated
3926:10.1016/s0378-1119(02)00386-4
3629:10.1016/s0896-6273(01)00193-3
2886:10.3410/f.734327820.793554446
2653:10.3410/f.718252264.793491785
2242:10.3410/f.734542901.793562583
2205:10.3410/f.734542901.793562583
1818:10.1016/S0378-1119(02)00386-4
1734:10.1016/S0378-1119(98)00605-2
293:
192:
4415:AMP-activated protein kinase
3526:10.1016/j.celrep.2019.10.115
3253:10.1016/j.neuron.2007.10.005
3065:, Penzes P (November 2009).
2402:10.1097/ogx.0000000000000460
2227:Lek M, Diab N (2019-07-15).
2190:Lek M, Diab N (2019-07-15).
1857:10.1016/j.neuron.2007.10.005
808:smooth muscle cell migration
6345:Genes on human chromosome 3
5330:(EC 2.7.11.21-EC 2.7.11.30)
3413:The Journal of Neuroscience
3179:The Journal of Neuroscience
3018:The Journal of Neuroscience
1946:The Journal of Neuroscience
1897:The Journal of Neuroscience
6381:
5257:Elongation factor 2 kinase
4221:(EC 2.7.11.1-EC 2.7.11.20)
4071:10.1177/002215540104900704
2010:10.1016/j.tins.2008.06.001
1541:10.1016/J.GENE.2020.145306
728:vesicle-mediated transport
703:nervous system development
6200:Michaelis–Menten kinetics
5959:
5945:
5652:MAP kinase kinase kinases
5335:
5321:
5184:Myosin light-chain kinase
4890:Ca2+/calmodulin-dependent
4555:Myosin-heavy-chain kinase
4226:
4212:
4101:Mandela P, Ma XM (2012).
3781:10.1016/j.mcn.2010.08.005
3717:Journal of Neurochemistry
3677:10.1016/j.mcn.2009.09.006
3475:10.1186/s12868-017-0363-2
2396:(6): 340–341. June 2017.
2350:10.1186/s40246-016-0082-2
2292:10.1038/s41525-018-0075-2
1659:"Mouse PubMed Reference:"
1641:"Human PubMed Reference:"
1516:article was published in
1351:
1346:
1342:
1335:
1319:
1306:Chr 3: 124.03 – 124.73 Mb
1300:
1281:
1216:
1185:
1166:
1069:
1038:
1025:
1021:
1006:
1002:
993:
980:
976:
961:
957:
948:
935:
931:
916:
912:
903:
888:
881:
877:
861:
798:adult locomotory behavior
626:GTPase activator activity
566:
562:
550:
545:
536:
523:
472:
463:
430:Descending thoracic aorta
410:
401:
371:
363:
359:
342:
329:
292:
271:
262:
258:
241:
228:
191:
168:
159:
155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
6092:Diffusion-limited enzyme
5952:Dual-specificity kinases
3831:10.1186/1471-2202-13-136
3370:10.1186/1471-2202-12-126
2638:Burdon KP (2014-03-07).
2450:10.3389/fgene.2016.00052
1685:Human Molecular Genetics
1313:Chr 16: 33.79 – 34.39 Mb
748:behavioral fear response
5375:Cyclin-dependent kinase
4017:10.1074/jbc.m115.636746
3966:10.1186/1471-2202-12-20
3316:10.1073/pnas.1600179113
3092:10.1073/pnas.0905884106
2536:Journal of Neuroscience
2081:10.1073/pnas.0904636106
1998:Trends in Neurosciences
708:protein phosphorylation
591:protein kinase activity
3882:10.1074/jbc.m000676200
2730:Schizophrenia Bulletin
2542:(2): 688. 2014-01-08.
2500:10.1124/mol.113.087106
2488:Molecular Pharmacology
2169:10.3233/jad-2007-11314
2131:10.3233/jad-2007-12309
1514:academic peer reviewed
1433:remodeling of synapses
6185:Eadie–Hofstee diagram
6118:Allosteric regulation
3142:10.1093/cercor/bhu182
2841:10.1038/sj.mp.4001792
2742:10.1093/schbul/sbq118
2673:Nature Communications
2595:Biological Psychiatry
2437:Frontiers in Genetics
1419:Clinical significance
652:extracellular exosome
500:primary visual cortex
442:primary visual cortex
434:right coronary artery
287:Chromosome 16 (mouse)
6195:Lineweaver–Burk plot
5218:Phosphorylase kinase
3519:(10): 2944–2952.e5.
2917:Molecular Psychiatry
2828:Molecular Psychiatry
2270:npj Genomic Medicine
1698:10.1093/hmg/6.9.1519
1522:and can be cited as:
1429:alternative splicing
672:postsynaptic density
581:transferase activity
480:primary motor cortex
185:Chromosome 3 (human)
62:List of PDB id codes
35:Available structures
4120:10.1155/2012/728161
3564:Nature Neuroscience
3307:2016PNAS..113.2264H
3083:2009PNAS..10619575J
2929:10.1038/mp.2016.152
2685:2014NatCo...5.4858R
2072:2009PNAS..10613058C
1441:Alzheimer's disease
733:signal transduction
6154:Enzyme superfamily
6087:Enzyme promiscuity
5829:Tropomyosin kinase
5783:Tau-protein kinase
2693:10.1038/ncomms5858
983:ENSMUSG00000061751
681:Biological process
647:actin cytoskeleton
635:Cellular component
586:nucleotide binding
574:Molecular function
512:hippocampus proper
446:right frontal lobe
6310:
6309:
6019:
6018:
6015:
6014:
6011:
6010:
5941:
5940:
5937:
5936:
5317:
5316:
5313:
5312:
4798:Protein kinase N1
4753:Protein kinase Cζ
4107:Neural Plasticity
2978:10.1111/ejn.14311
2923:(11): 1562–1575.
1583:
1582:
1362:
1361:
1358:
1357:
1331:
1330:
1296:
1295:
1271:
1270:
1181:
1180:
1156:
1155:
1034:
1033:
1015:
1014:
989:
988:
970:
969:
944:
943:
925:
924:
873:
872:
813:maternal behavior
601:metal ion binding
558:
557:
554:
553:
532:
531:
519:
518:
484:prefrontal cortex
457:
456:
355:
354:
254:
253:
149:KALRN - orthologs
81:
80:
77:
76:
45:Ortholog search:
6372:
6327:
6326:
6318:
6190:Hanes–Woolf plot
6133:Enzyme activator
6128:Enzyme inhibitor
6102:Enzyme catalysis
6046:
6039:
6032:
6023:
5961:
5947:
5594:C-Jun N-terminal
5337:
5323:
4827:Rhodopsin kinase
4818:Rhodopsin kinase
4748:Protein kinase C
4739:Protein kinase C
4724:Protein kinase G
4685:Protein kinase A
4296:Protein kinase B
4228:
4214:
4190:
4183:
4176:
4167:
4143:
4142:
4132:
4122:
4098:
4092:
4091:
4073:
4049:
4040:
4039:
4029:
4019:
4010:(21): 13541–55.
3995:
3989:
3988:
3978:
3968:
3953:BMC Neuroscience
3944:
3938:
3937:
3909:
3903:
3902:
3884:
3875:(25): 19324–33.
3860:
3854:
3853:
3843:
3833:
3818:BMC Neuroscience
3809:
3803:
3802:
3792:
3760:
3751:
3750:
3740:
3708:
3699:
3698:
3688:
3656:
3650:
3649:
3631:
3607:
3598:
3597:
3587:
3555:
3549:
3548:
3538:
3528:
3504:
3498:
3497:
3487:
3477:
3462:BMC Neuroscience
3453:
3447:
3446:
3436:
3419:(35): 12554–65.
3404:
3393:
3392:
3382:
3372:
3357:BMC Neuroscience
3348:
3339:
3338:
3328:
3318:
3286:
3275:
3274:
3264:
3232:
3223:
3222:
3204:
3194:
3170:
3164:
3163:
3153:
3136:(10): 3487–501.
3121:
3115:
3114:
3104:
3094:
3077:(46): 19575–80.
3058:
3052:
3051:
3041:
3009:
3000:
2999:
2989:
2972:(9): 1091–1101.
2957:
2951:
2950:
2940:
2908:
2899:
2898:
2888:
2877:Faculty Opinions
2868:
2862:
2861:
2843:
2819:
2813:
2812:
2802:
2770:
2764:
2763:
2753:
2721:
2715:
2714:
2704:
2664:
2658:
2657:
2655:
2644:Faculty Opinions
2635:
2629:
2628:
2618:
2586:
2580:
2579:
2569:
2551:
2528:
2522:
2521:
2511:
2479:
2473:
2472:
2462:
2452:
2428:
2422:
2421:
2387:
2379:
2373:
2372:
2362:
2352:
2328:
2322:
2321:
2303:
2285:
2261:
2255:
2254:
2244:
2233:Faculty Opinions
2224:
2218:
2217:
2207:
2196:Faculty Opinions
2187:
2181:
2180:
2152:
2143:
2142:
2113:
2104:
2103:
2093:
2083:
2066:(31): 13058–63.
2051:
2032:
2031:
2021:
1989:
1980:
1979:
1969:
1937:
1931:
1930:
1920:
1903:(47): 12368–82.
1888:
1879:
1878:
1868:
1836:
1830:
1829:
1801:
1795:
1794:
1784:
1752:
1746:
1745:
1717:
1711:
1710:
1700:
1676:
1667:
1666:
1655:
1649:
1648:
1637:
1631:
1621:
1610:
1600:
1578:
1560:
1507:
1499:
1367:, also known as
1344:
1343:
1315:
1308:
1291:
1275:
1266:
1190:
1186:RefSeq (protein)
1176:
1160:
1151:
1043:
1019:
1000:
974:
955:
929:
910:
879:
564:
543:
528:
468:
466:Top expressed in
461:
422:Brodmann area 10
414:secondary oocyte
406:
404:Top expressed in
399:
378:
361:
351:
338:
327:
312:
305:
299:
288:
276:
260:
250:
237:
226:
211:
204:
198:
187:
173:
157:
151:
102:
95:
72:
59:
53:
32:
31:
19:
6380:
6379:
6375:
6374:
6373:
6371:
6370:
6369:
6335:
6334:
6333:
6321:
6313:
6311:
6306:
6218:Oxidoreductases
6204:
6180:Enzyme kinetics
6168:
6164:List of enzymes
6137:
6106:
6077:Catalytic triad
6055:
6050:
6020:
6007:
5955:
5933:
5857:
5840:
5823:
5806:
5777:
5637:
5537:
5508:P70-S6 Kinase 1
5478:
5369:
5331:
5309:
5275:
5251:
5212:
5178:
4884:
4855:
4831:
4812:
4733:
4709:
4670:
4626:
4609:
4585:
4579:Aurora C kinase
4574:Aurora B kinase
4569:Aurora A kinase
4549:
4530:
4496:
4467:
4400:
4366:
4222:
4208:
4194:
4151:
4146:
4100:
4099:
4095:
4051:
4050:
4043:
3997:
3996:
3992:
3946:
3945:
3941:
3911:
3910:
3906:
3862:
3861:
3857:
3811:
3810:
3806:
3762:
3761:
3754:
3710:
3709:
3702:
3658:
3657:
3653:
3609:
3608:
3601:
3576:10.1038/nn.2487
3557:
3556:
3552:
3506:
3505:
3501:
3455:
3454:
3450:
3406:
3405:
3396:
3350:
3349:
3342:
3288:
3287:
3278:
3234:
3233:
3226:
3185:(16): 6980–90.
3172:
3171:
3167:
3130:Cerebral Cortex
3123:
3122:
3118:
3060:
3059:
3055:
3024:(21): 8426–34.
3011:
3010:
3003:
2959:
2958:
2954:
2910:
2909:
2902:
2870:
2869:
2865:
2821:
2820:
2816:
2772:
2771:
2767:
2723:
2722:
2718:
2666:
2665:
2661:
2637:
2636:
2632:
2588:
2587:
2583:
2530:
2529:
2525:
2481:
2480:
2476:
2430:
2429:
2425:
2385:
2381:
2380:
2376:
2330:
2329:
2325:
2263:
2262:
2258:
2226:
2225:
2221:
2189:
2188:
2184:
2154:
2153:
2146:
2115:
2114:
2107:
2053:
2052:
2035:
1991:
1990:
1983:
1939:
1938:
1934:
1890:
1889:
1882:
1838:
1837:
1833:
1803:
1802:
1798:
1767:(12): 5106–18.
1754:
1753:
1749:
1719:
1718:
1714:
1678:
1677:
1670:
1657:
1656:
1652:
1639:
1638:
1634:
1622:
1613:
1601:
1592:
1588:
1579:
1524:
1523:
1508:
1495:
1486:
1469:
1421:
1353:View/Edit Mouse
1348:View/Edit Human
1311:
1304:
1301:Location (UCSC)
1287:
1283:
1262:
1258:
1254:
1250:
1246:
1242:
1238:
1234:
1230:
1226:
1222:
1218:
1212:
1208:
1204:
1200:
1196:
1172:
1168:
1147:
1143:
1139:
1135:
1131:
1127:
1123:
1119:
1115:
1111:
1107:
1103:
1099:
1095:
1091:
1087:
1083:
1079:
1075:
1071:
1065:
1061:
1057:
1053:
1049:
964:ENSG00000160145
857:
753:social behavior
693:phosphorylation
676:
630:
616:protein binding
606:kinase activity
524:
515:
510:
506:
502:
498:
494:
490:
486:
482:
478:
476:cingulate gyrus
464:
453:
448:
444:
440:
436:
432:
428:
426:ascending aorta
424:
420:
416:
402:
346:
333:
325:
315:
314:
313:
306:
286:
263:Gene location (
245:
232:
224:
214:
213:
212:
205:
183:
160:Gene location (
111:
98:
91:
68:
46:
17:
12:
11:
5:
6378:
6376:
6368:
6367:
6362:
6357:
6352:
6347:
6337:
6336:
6332:
6331:
6308:
6307:
6305:
6304:
6291:
6278:
6265:
6252:
6239:
6226:
6212:
6210:
6206:
6205:
6203:
6202:
6197:
6192:
6187:
6182:
6176:
6174:
6170:
6169:
6167:
6166:
6161:
6156:
6151:
6145:
6143:
6142:Classification
6139:
6138:
6136:
6135:
6130:
6125:
6120:
6114:
6112:
6108:
6107:
6105:
6104:
6099:
6094:
6089:
6084:
6079:
6074:
6069:
6063:
6061:
6057:
6056:
6051:
6049:
6048:
6041:
6034:
6026:
6017:
6016:
6013:
6012:
6009:
6008:
6006:
6005:
6000:
5995:
5990:
5985:
5980:
5975:
5969:
5967:
5957:
5956:
5950:
5943:
5942:
5939:
5938:
5935:
5934:
5932:
5931:
5926:
5921:
5916:
5911:
5906:
5901:
5896:
5895:
5894:
5889:
5884:
5879:
5868:
5866:
5865:(EC 2.7.11.30)
5859:
5858:
5856:
5855:
5851:
5849:
5848:(EC 2.7.11.29)
5842:
5841:
5839:
5838:
5834:
5832:
5831:(EC 2.7.11.28)
5825:
5824:
5822:
5821:
5817:
5815:
5814:(EC 2.7.11.27)
5808:
5807:
5805:
5804:
5799:
5794:
5788:
5786:
5785:(EC 2.7.11.26)
5779:
5778:
5776:
5775:
5770:
5765:
5764:
5763:
5758:
5753:
5748:
5743:
5738:
5733:
5723:
5722:
5721:
5716:
5711:
5706:
5696:
5695:
5694:
5689:
5684:
5679:
5674:
5669:
5664:
5659:
5648:
5646:
5645:(EC 2.7.11.25)
5639:
5638:
5636:
5635:
5634:
5633:
5628:
5623:
5613:
5612:
5611:
5606:
5601:
5591:
5590:
5589:
5584:
5579:
5574:
5569:
5564:
5559:
5548:
5546:
5545:(EC 2.7.11.24)
5539:
5538:
5536:
5535:
5530:
5525:
5520:
5515:
5510:
5505:
5500:
5495:
5489:
5487:
5486:(EC 2.7.11.23)
5480:
5479:
5477:
5476:
5471:
5466:
5461:
5456:
5451:
5446:
5441:
5436:
5431:
5426:
5421:
5416:
5411:
5406:
5401:
5396:
5391:
5386:
5380:
5378:
5377:(EC 2.7.11.22)
5371:
5370:
5368:
5367:
5362:
5357:
5352:
5346:
5344:
5343:(EC 2.7.11.21)
5333:
5332:
5326:
5319:
5318:
5315:
5314:
5311:
5310:
5308:
5307:
5302:
5297:
5292:
5286:
5284:
5283:(EC 2.7.11.21)
5277:
5276:
5274:
5273:
5268:
5262:
5260:
5259:(EC 2.7.11.20)
5253:
5252:
5250:
5249:
5244:
5239:
5234:
5229:
5223:
5221:
5220:(EC 2.7.11.19)
5214:
5213:
5211:
5210:
5205:
5200:
5195:
5189:
5187:
5186:(EC 2.7.11.18)
5180:
5179:
5177:
5176:
5171:
5166:
5161:
5156:
5151:
5146:
5141:
5136:
5131:
5126:
5121:
5116:
5111:
5106:
5101:
5096:
5091:
5086:
5081:
5076:
5071:
5066:
5061:
5056:
5051:
5046:
5041:
5036:
5031:
5026:
5021:
5016:
5011:
5006:
5001:
4996:
4991:
4986:
4981:
4976:
4971:
4966:
4961:
4956:
4951:
4946:
4941:
4936:
4931:
4926:
4921:
4916:
4911:
4906:
4901:
4895:
4893:
4892:(EC 2.7.11.17)
4886:
4885:
4883:
4882:
4877:
4872:
4866:
4864:
4863:(EC 2.7.11.16)
4857:
4856:
4854:
4853:
4848:
4842:
4840:
4839:(EC 2.7.11.15)
4833:
4832:
4830:
4829:
4823:
4821:
4820:(EC 2.7.11.14)
4814:
4813:
4811:
4810:
4805:
4800:
4795:
4790:
4785:
4780:
4775:
4770:
4765:
4760:
4755:
4750:
4744:
4742:
4741:(EC 2.7.11.13)
4735:
4734:
4732:
4731:
4726:
4720:
4718:
4717:(EC 2.7.11.12)
4711:
4710:
4708:
4707:
4702:
4697:
4692:
4687:
4681:
4679:
4678:(EC 2.7.11.11)
4672:
4671:
4669:
4668:
4663:
4658:
4653:
4648:
4643:
4637:
4635:
4634:(EC 2.7.11.10)
4628:
4627:
4625:
4624:
4620:
4618:
4611:
4610:
4608:
4607:
4602:
4596:
4594:
4587:
4586:
4584:
4583:
4582:
4581:
4576:
4571:
4560:
4558:
4551:
4550:
4548:
4547:
4541:
4539:
4532:
4531:
4529:
4528:
4523:
4518:
4513:
4507:
4505:
4498:
4497:
4495:
4494:
4489:
4484:
4478:
4476:
4469:
4468:
4466:
4465:
4464:
4463:
4458:
4453:
4445:
4444:
4443:
4438:
4430:
4429:
4428:
4423:
4411:
4409:
4402:
4401:
4399:
4398:
4393:
4388:
4383:
4377:
4375:
4368:
4367:
4365:
4364:
4363:
4362:
4352:
4351:
4350:
4345:
4340:
4335:
4325:
4320:
4315:
4314:
4313:
4308:
4303:
4293:
4288:
4283:
4278:
4273:
4268:
4263:
4258:
4253:
4248:
4243:
4237:
4235:
4224:
4223:
4217:
4210:
4209:
4195:
4193:
4192:
4185:
4178:
4170:
4164:
4163:
4157:
4150:
4149:External links
4147:
4145:
4144:
4093:
4041:
3990:
3939:
3920:(1–2): 41–51.
3904:
3855:
3804:
3752:
3700:
3651:
3599:
3550:
3499:
3448:
3394:
3340:
3276:
3224:
3165:
3116:
3053:
3001:
2952:
2900:
2863:
2814:
2779:Brain Research
2765:
2716:
2659:
2630:
2581:
2523:
2474:
2423:
2374:
2337:Human Genomics
2323:
2283:10.1101/363853
2256:
2219:
2182:
2144:
2105:
2033:
1981:
1952:(17): 5367–9.
1932:
1880:
1831:
1812:(1–2): 41–51.
1796:
1747:
1712:
1691:(9): 1519–25.
1668:
1650:
1632:
1611:
1589:
1587:
1584:
1581:
1580:
1511:
1509:
1502:
1494:
1491:
1485:
1482:
1468:
1465:
1420:
1417:
1360:
1359:
1356:
1355:
1350:
1340:
1339:
1333:
1332:
1329:
1328:
1326:
1324:
1317:
1316:
1309:
1302:
1298:
1297:
1294:
1293:
1279:
1278:
1272:
1269:
1268:
1214:
1213:
1187:
1183:
1182:
1179:
1178:
1164:
1163:
1157:
1154:
1153:
1067:
1066:
1040:
1036:
1035:
1032:
1031:
1023:
1022:
1016:
1013:
1012:
1004:
1003:
997:
991:
990:
987:
986:
978:
977:
971:
968:
967:
959:
958:
952:
946:
945:
942:
941:
933:
932:
926:
923:
922:
914:
913:
907:
901:
900:
895:
890:
886:
885:
875:
874:
871:
870:
859:
858:
856:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
684:
682:
678:
677:
675:
674:
669:
664:
659:
654:
649:
644:
638:
636:
632:
631:
629:
628:
623:
618:
613:
608:
603:
598:
593:
588:
583:
577:
575:
571:
570:
560:
559:
556:
555:
552:
551:
548:
547:
540:
534:
533:
530:
529:
521:
520:
517:
516:
514:
513:
509:
505:
501:
497:
493:
489:
485:
481:
477:
473:
470:
469:
458:
455:
454:
452:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
411:
408:
407:
395:
394:
386:
375:
369:
368:
365:RNA expression
357:
356:
353:
352:
344:
340:
339:
331:
328:
323:
317:
316:
307:
300:
294:
290:
289:
284:
278:
277:
269:
268:
256:
255:
252:
251:
243:
239:
238:
230:
227:
222:
216:
215:
206:
199:
193:
189:
188:
181:
175:
174:
166:
165:
153:
152:
109:
105:
104:
96:
88:
87:
83:
82:
79:
78:
75:
74:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
6377:
6366:
6363:
6361:
6358:
6356:
6353:
6351:
6348:
6346:
6343:
6342:
6340:
6330:
6325:
6320:
6316:
6302:
6298:
6297:
6292:
6289:
6285:
6284:
6279:
6276:
6272:
6271:
6266:
6263:
6259:
6258:
6253:
6250:
6246:
6245:
6240:
6237:
6233:
6232:
6227:
6224:
6220:
6219:
6214:
6213:
6211:
6207:
6201:
6198:
6196:
6193:
6191:
6188:
6186:
6183:
6181:
6178:
6177:
6175:
6171:
6165:
6162:
6160:
6159:Enzyme family
6157:
6155:
6152:
6150:
6147:
6146:
6144:
6140:
6134:
6131:
6129:
6126:
6124:
6123:Cooperativity
6121:
6119:
6116:
6115:
6113:
6109:
6103:
6100:
6098:
6095:
6093:
6090:
6088:
6085:
6083:
6082:Oxyanion hole
6080:
6078:
6075:
6073:
6070:
6068:
6065:
6064:
6062:
6058:
6054:
6047:
6042:
6040:
6035:
6033:
6028:
6027:
6024:
6004:
6001:
5999:
5996:
5994:
5991:
5989:
5986:
5984:
5981:
5979:
5976:
5974:
5971:
5970:
5968:
5966:
5962:
5958:
5953:
5948:
5944:
5930:
5927:
5925:
5922:
5920:
5917:
5915:
5912:
5910:
5907:
5905:
5902:
5900:
5897:
5893:
5890:
5888:
5885:
5883:
5880:
5878:
5875:
5874:
5873:
5870:
5869:
5867:
5864:
5860:
5853:
5852:
5850:
5847:
5843:
5836:
5835:
5833:
5830:
5826:
5819:
5818:
5816:
5813:
5809:
5803:
5800:
5798:
5795:
5793:
5790:
5789:
5787:
5784:
5780:
5774:
5771:
5769:
5766:
5762:
5759:
5757:
5754:
5752:
5749:
5747:
5744:
5742:
5739:
5737:
5734:
5732:
5729:
5728:
5727:
5724:
5720:
5717:
5715:
5712:
5710:
5707:
5705:
5702:
5701:
5700:
5697:
5693:
5690:
5688:
5685:
5683:
5680:
5678:
5675:
5673:
5670:
5668:
5665:
5663:
5660:
5658:
5655:
5654:
5653:
5650:
5649:
5647:
5644:
5640:
5632:
5629:
5627:
5624:
5622:
5619:
5618:
5617:
5614:
5610:
5607:
5605:
5602:
5600:
5597:
5596:
5595:
5592:
5588:
5585:
5583:
5580:
5578:
5575:
5573:
5570:
5568:
5565:
5563:
5560:
5558:
5555:
5554:
5553:
5550:
5549:
5547:
5544:
5540:
5534:
5531:
5529:
5526:
5524:
5521:
5519:
5516:
5514:
5511:
5509:
5506:
5504:
5501:
5499:
5496:
5494:
5491:
5490:
5488:
5485:
5481:
5475:
5472:
5470:
5467:
5465:
5462:
5460:
5457:
5455:
5452:
5450:
5447:
5445:
5442:
5440:
5437:
5435:
5432:
5430:
5427:
5425:
5422:
5420:
5417:
5415:
5412:
5410:
5407:
5405:
5402:
5400:
5397:
5395:
5392:
5390:
5387:
5385:
5382:
5381:
5379:
5376:
5372:
5366:
5363:
5361:
5358:
5356:
5353:
5351:
5348:
5347:
5345:
5342:
5338:
5334:
5329:
5324:
5320:
5306:
5303:
5301:
5298:
5296:
5293:
5291:
5288:
5287:
5285:
5282:
5278:
5272:
5269:
5267:
5264:
5263:
5261:
5258:
5254:
5248:
5245:
5243:
5240:
5238:
5235:
5233:
5230:
5228:
5225:
5224:
5222:
5219:
5215:
5209:
5206:
5204:
5201:
5199:
5196:
5194:
5191:
5190:
5188:
5185:
5181:
5175:
5172:
5170:
5167:
5165:
5162:
5160:
5157:
5155:
5152:
5150:
5147:
5145:
5142:
5140:
5137:
5135:
5132:
5130:
5127:
5125:
5122:
5120:
5117:
5115:
5112:
5110:
5107:
5105:
5102:
5100:
5097:
5095:
5092:
5090:
5087:
5085:
5082:
5080:
5077:
5075:
5072:
5070:
5067:
5065:
5062:
5060:
5057:
5055:
5052:
5050:
5047:
5045:
5042:
5040:
5037:
5035:
5032:
5030:
5027:
5025:
5022:
5020:
5017:
5015:
5012:
5010:
5007:
5005:
5002:
5000:
4997:
4995:
4992:
4990:
4987:
4985:
4982:
4980:
4977:
4975:
4972:
4970:
4967:
4965:
4962:
4960:
4957:
4955:
4952:
4950:
4947:
4945:
4942:
4940:
4937:
4935:
4932:
4930:
4927:
4925:
4922:
4920:
4917:
4915:
4912:
4910:
4907:
4905:
4902:
4900:
4897:
4896:
4894:
4891:
4887:
4881:
4878:
4876:
4873:
4871:
4868:
4867:
4865:
4862:
4858:
4852:
4849:
4847:
4844:
4843:
4841:
4838:
4834:
4828:
4825:
4824:
4822:
4819:
4815:
4809:
4806:
4804:
4801:
4799:
4796:
4794:
4791:
4789:
4786:
4784:
4781:
4779:
4776:
4774:
4771:
4769:
4766:
4764:
4761:
4759:
4756:
4754:
4751:
4749:
4746:
4745:
4743:
4740:
4736:
4730:
4727:
4725:
4722:
4721:
4719:
4716:
4712:
4706:
4703:
4701:
4698:
4696:
4693:
4691:
4688:
4686:
4683:
4682:
4680:
4677:
4673:
4667:
4664:
4662:
4659:
4657:
4654:
4652:
4649:
4647:
4644:
4642:
4639:
4638:
4636:
4633:
4629:
4622:
4621:
4619:
4617:(EC 2.7.11.9)
4616:
4612:
4606:
4603:
4601:
4598:
4597:
4595:
4593:(EC 2.7.11.8)
4592:
4588:
4580:
4577:
4575:
4572:
4570:
4567:
4566:
4565:
4564:Aurora kinase
4562:
4561:
4559:
4557:(EC 2.7.11.7)
4556:
4552:
4546:
4543:
4542:
4540:
4538:(EC 2.7.11.6)
4537:
4533:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4508:
4506:
4504:(EC 2.7.11.5)
4503:
4499:
4493:
4490:
4488:
4485:
4483:
4480:
4479:
4477:
4475:(EC 2.7.11.4)
4474:
4470:
4462:
4459:
4457:
4454:
4452:
4449:
4448:
4446:
4442:
4439:
4437:
4434:
4433:
4431:
4427:
4424:
4422:
4419:
4418:
4416:
4413:
4412:
4410:
4408:(EC 2.7.11.3)
4407:
4403:
4397:
4394:
4392:
4389:
4387:
4384:
4382:
4379:
4378:
4376:
4374:(EC 2.7.11.2)
4373:
4369:
4361:
4358:
4357:
4356:
4353:
4349:
4346:
4344:
4341:
4339:
4336:
4334:
4331:
4330:
4329:
4328:EIF-2 kinases
4326:
4324:
4321:
4319:
4316:
4312:
4309:
4307:
4304:
4302:
4299:
4298:
4297:
4294:
4292:
4289:
4287:
4284:
4282:
4279:
4277:
4274:
4272:
4269:
4267:
4264:
4262:
4259:
4257:
4254:
4252:
4249:
4247:
4244:
4242:
4239:
4238:
4236:
4234:(EC 2.7.11.1)
4233:
4229:
4225:
4220:
4215:
4211:
4206:
4202:
4198:
4191:
4186:
4184:
4179:
4177:
4172:
4171:
4168:
4161:
4158:
4156:
4153:
4152:
4148:
4140:
4136:
4131:
4126:
4121:
4116:
4112:
4108:
4104:
4097:
4094:
4089:
4085:
4081:
4077:
4072:
4067:
4064:(7): 833–44.
4063:
4059:
4055:
4048:
4046:
4042:
4037:
4033:
4028:
4023:
4018:
4013:
4009:
4005:
4001:
3994:
3991:
3986:
3982:
3977:
3972:
3967:
3962:
3958:
3954:
3950:
3943:
3940:
3935:
3931:
3927:
3923:
3919:
3915:
3908:
3905:
3900:
3896:
3892:
3888:
3883:
3878:
3874:
3870:
3866:
3859:
3856:
3851:
3847:
3842:
3837:
3832:
3827:
3823:
3819:
3815:
3808:
3805:
3800:
3796:
3791:
3786:
3782:
3778:
3774:
3770:
3766:
3759:
3757:
3753:
3748:
3744:
3739:
3734:
3730:
3726:
3722:
3718:
3714:
3707:
3705:
3701:
3696:
3692:
3687:
3682:
3678:
3674:
3670:
3666:
3662:
3655:
3652:
3647:
3643:
3639:
3635:
3630:
3625:
3622:(1): 229–42.
3621:
3617:
3613:
3606:
3604:
3600:
3595:
3591:
3586:
3581:
3577:
3573:
3570:(3): 327–32.
3569:
3565:
3561:
3554:
3551:
3546:
3542:
3537:
3532:
3527:
3522:
3518:
3514:
3510:
3503:
3500:
3495:
3491:
3486:
3481:
3476:
3471:
3467:
3463:
3459:
3452:
3449:
3444:
3440:
3435:
3430:
3426:
3422:
3418:
3414:
3410:
3403:
3401:
3399:
3395:
3390:
3386:
3381:
3376:
3371:
3366:
3362:
3358:
3354:
3347:
3345:
3341:
3336:
3332:
3327:
3322:
3317:
3312:
3308:
3304:
3301:(8): 2264–9.
3300:
3296:
3292:
3285:
3283:
3281:
3277:
3272:
3268:
3263:
3258:
3254:
3250:
3247:(4): 640–56.
3246:
3242:
3238:
3231:
3229:
3225:
3220:
3216:
3212:
3208:
3203:
3198:
3193:
3188:
3184:
3180:
3176:
3169:
3166:
3161:
3157:
3152:
3147:
3143:
3139:
3135:
3131:
3127:
3120:
3117:
3112:
3108:
3103:
3098:
3093:
3088:
3084:
3080:
3076:
3072:
3068:
3064:
3057:
3054:
3049:
3045:
3040:
3035:
3031:
3027:
3023:
3019:
3015:
3008:
3006:
3002:
2997:
2993:
2988:
2983:
2979:
2975:
2971:
2967:
2963:
2956:
2953:
2948:
2944:
2939:
2934:
2930:
2926:
2922:
2918:
2914:
2907:
2905:
2901:
2896:
2892:
2887:
2882:
2878:
2874:
2867:
2864:
2859:
2855:
2851:
2847:
2842:
2837:
2834:(6): 557–66.
2833:
2829:
2825:
2818:
2815:
2810:
2806:
2801:
2796:
2792:
2788:
2784:
2780:
2776:
2769:
2766:
2761:
2757:
2752:
2747:
2743:
2739:
2736:(3): 552–60.
2735:
2731:
2727:
2720:
2717:
2712:
2708:
2703:
2698:
2694:
2690:
2686:
2682:
2678:
2674:
2670:
2663:
2660:
2654:
2649:
2645:
2641:
2634:
2631:
2626:
2622:
2617:
2612:
2608:
2604:
2601:(3): 249–55.
2600:
2596:
2592:
2585:
2582:
2577:
2573:
2568:
2563:
2559:
2555:
2550:
2545:
2541:
2537:
2533:
2527:
2524:
2519:
2515:
2510:
2505:
2501:
2497:
2494:(4): 582–90.
2493:
2489:
2485:
2478:
2475:
2470:
2466:
2461:
2456:
2451:
2446:
2442:
2438:
2434:
2427:
2424:
2419:
2415:
2411:
2407:
2403:
2399:
2395:
2391:
2384:
2378:
2375:
2370:
2366:
2361:
2356:
2351:
2346:
2342:
2338:
2334:
2327:
2324:
2319:
2315:
2311:
2307:
2302:
2297:
2293:
2289:
2284:
2279:
2275:
2271:
2267:
2260:
2257:
2252:
2248:
2243:
2238:
2234:
2230:
2223:
2220:
2215:
2211:
2206:
2201:
2197:
2193:
2186:
2183:
2178:
2174:
2170:
2166:
2163:(3): 385–97.
2162:
2158:
2151:
2149:
2145:
2140:
2136:
2132:
2128:
2125:(3): 271–81.
2124:
2120:
2112:
2110:
2106:
2101:
2097:
2092:
2087:
2082:
2077:
2073:
2069:
2065:
2061:
2057:
2050:
2048:
2046:
2044:
2042:
2040:
2038:
2034:
2029:
2025:
2020:
2015:
2011:
2007:
2004:(8): 419–27.
2003:
1999:
1995:
1988:
1986:
1982:
1977:
1973:
1968:
1963:
1959:
1955:
1951:
1947:
1943:
1936:
1933:
1928:
1924:
1919:
1914:
1910:
1906:
1902:
1898:
1894:
1887:
1885:
1881:
1876:
1872:
1867:
1862:
1858:
1854:
1851:(4): 640–56.
1850:
1846:
1842:
1835:
1832:
1827:
1823:
1819:
1815:
1811:
1807:
1800:
1797:
1792:
1788:
1783:
1778:
1774:
1770:
1766:
1762:
1758:
1751:
1748:
1743:
1739:
1735:
1731:
1728:(2): 249–55.
1727:
1723:
1716:
1713:
1708:
1704:
1699:
1694:
1690:
1686:
1682:
1675:
1673:
1669:
1664:
1660:
1654:
1651:
1646:
1642:
1636:
1633:
1629:
1625:
1620:
1618:
1616:
1612:
1608:
1604:
1599:
1597:
1595:
1591:
1585:
1576:
1572:
1568:
1564:
1559:
1554:
1550:
1546:
1542:
1538:
1534:
1533:
1528:
1521:
1520:
1515:
1510:
1506:
1501:
1500:
1497:
1492:
1490:
1483:
1481:
1477:
1473:
1466:
1464:
1460:
1457:
1451:
1447:
1444:
1442:
1438:
1437:schizophrenia
1434:
1430:
1426:
1418:
1416:
1414:
1410:
1405:
1403:
1400:
1395:
1393:
1389:
1386:
1382:
1378:
1374:
1370:
1366:
1354:
1349:
1345:
1341:
1338:
1334:
1327:
1325:
1322:
1318:
1314:
1310:
1307:
1303:
1299:
1292:
1290:
1286:
1280:
1276:
1273:
1267:
1265:
1261:
1257:
1253:
1249:
1245:
1241:
1237:
1233:
1229:
1225:
1221:
1215:
1211:
1207:
1203:
1199:
1195:
1191:
1188:
1184:
1177:
1175:
1171:
1165:
1161:
1158:
1152:
1150:
1146:
1142:
1138:
1134:
1130:
1126:
1122:
1118:
1114:
1110:
1106:
1102:
1098:
1094:
1090:
1086:
1082:
1078:
1074:
1068:
1064:
1060:
1056:
1052:
1048:
1044:
1041:
1039:RefSeq (mRNA)
1037:
1030:
1029:
1024:
1020:
1017:
1011:
1010:
1005:
1001:
998:
996:
992:
985:
984:
979:
975:
972:
966:
965:
960:
956:
953:
951:
947:
940:
939:
934:
930:
927:
921:
920:
915:
911:
908:
906:
902:
899:
896:
894:
891:
887:
884:
880:
876:
869:
865:
860:
854:
851:
849:
846:
844:
841:
839:
836:
834:
831:
829:
826:
824:
821:
819:
816:
814:
811:
809:
806:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
685:
683:
680:
679:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
639:
637:
634:
633:
627:
624:
622:
619:
617:
614:
612:
609:
607:
604:
602:
599:
597:
594:
592:
589:
587:
584:
582:
579:
578:
576:
573:
572:
569:
568:Gene ontology
565:
561:
549:
544:
541:
539:
535:
527:
522:
511:
507:
503:
499:
496:visual cortex
495:
492:dentate gyrus
491:
487:
483:
479:
475:
474:
471:
467:
462:
459:
449:
445:
441:
437:
433:
429:
425:
421:
417:
413:
412:
409:
405:
400:
397:
396:
393:
391:
387:
385:
384:
380:
379:
376:
374:
370:
366:
362:
358:
350:
345:
341:
337:
332:
326:16|16 B3
322:
318:
311:
304:
298:
291:
283:
279:
275:
270:
266:
261:
257:
249:
244:
240:
236:
231:
221:
217:
210:
203:
197:
190:
186:
180:
176:
172:
167:
163:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
106:
101:
94:
89:
84:
73:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
6296:Translocases
6293:
6280:
6267:
6254:
6241:
6231:Transferases
6228:
6215:
6072:Binding site
5503:P70S6 kinase
5143:
4110:
4106:
4096:
4061:
4057:
4007:
4003:
3993:
3956:
3952:
3942:
3917:
3913:
3907:
3872:
3868:
3858:
3821:
3817:
3807:
3775:(1): 45–54.
3772:
3768:
3723:(5): 781–9.
3720:
3716:
3668:
3664:
3654:
3619:
3615:
3567:
3563:
3553:
3516:
3513:Cell Reports
3512:
3502:
3465:
3461:
3451:
3416:
3412:
3360:
3356:
3298:
3294:
3244:
3240:
3182:
3178:
3168:
3133:
3129:
3119:
3074:
3070:
3056:
3021:
3017:
2969:
2965:
2955:
2920:
2916:
2876:
2866:
2831:
2827:
2817:
2782:
2778:
2768:
2733:
2729:
2719:
2676:
2672:
2662:
2643:
2633:
2598:
2594:
2584:
2539:
2535:
2526:
2491:
2487:
2477:
2440:
2436:
2426:
2393:
2389:
2377:
2340:
2336:
2326:
2273:
2269:
2259:
2232:
2222:
2195:
2185:
2160:
2156:
2122:
2118:
2063:
2059:
2001:
1997:
1949:
1945:
1935:
1900:
1896:
1848:
1844:
1834:
1809:
1805:
1799:
1764:
1760:
1750:
1725:
1721:
1715:
1688:
1684:
1662:
1653:
1644:
1635:
1530:
1518:
1517:
1496:
1487:
1478:
1474:
1470:
1461:
1455:
1452:
1448:
1445:
1422:
1406:
1396:
1384:
1376:
1372:
1368:
1364:
1363:
1285:NP_001157740
1282:
1256:NP_001309930
1252:NP_001309929
1248:NP_001309928
1244:NP_001309927
1240:NP_001309926
1236:NP_001309925
1232:NP_001309924
1228:NP_001309923
1224:NP_001309922
1220:NP_001309921
1217:
1210:NP_001309920
1206:NP_001309919
1202:NP_001309918
1198:NP_001309917
1194:NP_001019831
1170:NM_001164268
1167:
1149:NM_001388419
1145:NM_001388418
1141:NM_001388417
1137:NM_001388416
1133:NM_001388415
1129:NM_001388414
1125:NM_001388413
1121:NM_001388412
1117:NM_001323001
1113:NM_001323000
1109:NM_001322999
1105:NM_001322998
1101:NM_001322997
1097:NM_001322996
1093:NM_001322995
1089:NM_001322994
1085:NM_001322993
1081:NM_001322992
1077:NM_001322991
1073:NM_001322990
1070:
1063:NM_001322989
1059:NM_001322988
1047:NM_001024660
1026:
1007:
981:
962:
936:
917:
897:
892:
657:cytoskeleton
418:frontal pole
388:
381:
246:124,726,325
233:124,033,369
225:3q21.1-q21.2
108:External IDs
67:
6067:Active site
5954:(EC 2.7.12)
5341:Polo kinase
5281:Polo kinase
3671:(1): 81–9.
2679:(1): 4858.
1373:protein duo
818:habituation
662:nucleoplasm
621:ATP binding
450:sural nerve
347:34,393,902
334:33,789,443
86:Identifiers
6339:Categories
6270:Isomerases
6244:Hydrolases
6111:Regulation
4632:IκB kinase
4207:2.7.11-12)
4113:: 728161.
3824:(1): 136.
3363:(1): 126.
2785:: 235–48.
1630:, May 2017
1609:, May 2017
1586:References
1575:Q102060922
1484:Expression
1375:(DUO), or
392:(ortholog)
129:HomoloGene
6360:EC 2.7.11
6149:EC number
4758:PKC alpha
3959:(1): 20.
3468:(1): 45.
2576:219222516
2558:0270-6474
2410:0029-7828
2343:(1): 26.
2318:196670411
2251:199641906
2214:199641906
1549:0378-1119
1456:promoting
1371:(HAPIP),
1289:NP_796331
1264:NP_008995
1260:NP_003938
1174:NM_177357
1055:NM_007064
1051:NM_003947
883:Orthologs
793:lactation
642:cytoplasm
488:CA3 field
137:GeneCards
6173:Kinetics
6097:Cofactor
6060:Activity
5114:KIAA0999
5009:MAPKAPK5
5004:MAPKAPK3
4999:MAPKAPK2
4139:22548195
4088:14973698
4080:11410608
4036:25861993
3985:21329509
3934:11891045
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3799:20708080
3747:22862288
3695:19800004
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3594:20139976
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3494:28535798
3443:21880917
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3335:26858404
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3219:15927856
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3160:25146373
3111:19889983
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2996:30565792
2947:27646263
2895:91384966
2850:16402129
2809:18778695
2760:21041834
2711:25224588
2625:20452575
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2469:27092175
2418:79759435
2369:27421267
2310:30675382
2177:17851188
2139:18057561
2100:19625617
2028:18597863
1976:19403804
1927:19020030
1875:18031682
1826:11891045
1791:15923627
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1425:isoforms
1423:Several
1337:Wikidata
862:Sources:
6329:Biology
6283:Ligases
6053:Enzymes
5773:MAP3K14
5751:MAP3K11
5746:MAP3K10
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5731:MAP3K12
5533:RPS6KC1
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5518:RPS6KA2
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5498:RPS6KA4
5493:RPS6KA5
5144:Kalirin
5109:SNF1LK2
4348:EIF2AK4
4343:EIF2AK3
4197:Kinases
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4027:4505600
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3790:3576140
3738:3493825
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3326:4776457
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1707:9285789
1628:Ensembl
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265:Mouse
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