28:
87:
with ketolides, which are used to treat serious infections, the more powerful drugs (ketolides) were the more "leaky" in blocking the production of proteins. The researchers were surprised to discover that ketolides, which are known to be better antibiotics, allow for many more proteins to be made
88:
compared to the older, less efficient macrolides. As a result, it is now believed that allowing cells to make some proteins could be much more damaging for a microbe than not letting it make any proteins at all. The findings may point the way to better and more potent antibiotics.
216:
83:
by binding to ribosomal subunits and may also inhibit the formation of newly forming ribosomes. According to a recent study comparing the action of the classic macrolides erythromycin and
209:
202:
1012:
194:
68:
ring. These modifications give ketolides much broader spectrum than other macrolides. Moreover, ketolides are effective against
1056:
120:
1029:
229:
69:
961:
76:
as well as having a structural modification that makes them poor substrates for efflux-pump mediated resistance.
480:
1017:
363:
717:
621:
272:
670:
299:
116:
154:
941:
937:
506:
167:
80:
989:
933:
561:
980:
975:
687:
556:
551:
1023:
840:
770:
755:
516:
401:
389:
267:
1050:
985:
929:
921:
883:
873:
845:
825:
815:
810:
775:
760:
697:
692:
616:
581:
369:
132:
124:
104:
92:
31:
969:
965:
893:
830:
800:
765:
735:
571:
546:
531:
521:
511:
485:
426:
374:
321:
294:
284:
249:
245:
241:
237:
233:
84:
49:
955:
901:
878:
805:
790:
785:
702:
589:
566:
541:
536:
526:
501:
345:
316:
100:
951:
911:
906:
855:
835:
820:
795:
750:
745:
679:
650:
630:
450:
445:
436:
431:
416:
411:
359:
311:
225:
41:
780:
740:
727:
660:
655:
645:
640:
635:
466:
421:
384:
379:
350:
340:
330:
128:
61:
53:
45:
171:
27:
335:
306:
73:
17:
850:
65:
947:
57:
26:
198:
123:
were removed as indications when it was recognized that use of
607:
258:
72:, due to their ability to bind at two sites at the bacterial
155:"Telithromycin: a brief review of a new ketolide antibiotic"
184:
Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor
920:
892:
864:
726:
715:
678:
669:
615:
606:
580:
494:
479:
459:
398:
281:
266:
257:
153:
91:The only ketolide on the market at this moment is
115:Ketolides are used to treat community-acquired
210:
8:
723:
675:
612:
491:
278:
263:
217:
203:
195:
188:McGraw-Hill 2009 via "accessmedicine.com"
99:. Other ketolides in development include
95:, which is sold under the brand name of
144:
186:Basic & Clinical Pharmacology, 11e
7:
48:group. Ketolides are derived from
25:
160:Journal of Drugs in Dermatology
718:transpeptidation/translocation
1:
121:respiratory tract infections
70:macrolide-resistant bacteria
152:Scheinfeld, N (July 2004).
1073:
1007:
962:Quinupristin/dalfopristin
230:inhibit protein synthesis
481:Tetracycline antibiotics
60:and attaching a cyclic
34:
30:
1057:Ketolide antibiotics
671:Peptidyl transferase
52:by substituting the
300:Dihydrostreptomycin
117:bacterial pneumonia
1034:Never to phase III
35:
1044:
1043:
1003:
1002:
999:
998:
711:
710:
602:
601:
598:
597:
507:Chlortetracycline
475:
474:
81:protein synthesis
44:belonging to the
16:(Redirected from
1064:
724:
676:
613:
562:Rolitetracycline
492:
279:
264:
219:
212:
205:
196:
189:
182:
176:
175:
157:
149:
79:Ketolides block
21:
1072:
1071:
1067:
1066:
1065:
1063:
1062:
1061:
1047:
1046:
1045:
1040:
1039:
1024:Clinical trials
995:
981:Streptogramin B
976:Streptogramin A
916:
888:
860:
707:
688:Chloramphenicol
665:
619:
594:
576:
557:Penimepicycline
552:Oxytetracycline
483:
471:
455:
394:
270:
268:Aminoglycosides
253:
223:
193:
192:
183:
179:
151:
150:
146:
141:
113:
23:
22:
15:
12:
11:
5:
1070:
1068:
1060:
1059:
1049:
1048:
1042:
1041:
1038:
1037:
1036:
1035:
1032:
1021:
1015:
1009:
1008:
1005:
1004:
1001:
1000:
997:
996:
994:
993:
983:
978:
973:
959:
945:
926:
924:
922:Streptogramins
918:
917:
915:
914:
909:
904:
898:
896:
890:
889:
887:
886:
881:
876:
870:
868:
862:
861:
859:
858:
853:
848:
843:
841:Troleandomycin
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
771:Flurithromycin
768:
763:
758:
756:Clarithromycin
753:
748:
743:
738:
732:
730:
721:
713:
712:
709:
708:
706:
705:
700:
695:
690:
684:
682:
673:
667:
666:
664:
663:
658:
653:
648:
643:
638:
633:
627:
625:
610:
604:
603:
600:
599:
596:
595:
593:
592:
586:
584:
582:Glycylcyclines
578:
577:
575:
574:
569:
564:
559:
554:
549:
544:
539:
534:
529:
524:
519:
517:Demeclocycline
514:
509:
504:
498:
496:
489:
477:
476:
473:
472:
470:
469:
463:
461:
457:
456:
454:
453:
448:
442:
441:
440:
439:
434:
429:
424:
419:
408:
406:
402:Micromonospora
396:
395:
393:
392:
390:Nourseothricin
387:
382:
377:
372:
367:
356:
355:
354:
353:
348:
343:
338:
327:
326:
325:
324:
319:
314:
303:
302:
297:
291:
289:
276:
261:
255:
254:
226:Antibacterials
224:
222:
221:
214:
207:
199:
191:
190:
177:
143:
142:
140:
137:
127:can result in
112:
109:
24:
14:
13:
10:
9:
6:
4:
3:
2:
1069:
1058:
1055:
1054:
1052:
1033:
1031:
1028:
1027:
1025:
1022:
1019:
1016:
1014:
1011:
1010:
1006:
991:
987:
986:Virginiamycin
984:
982:
979:
977:
974:
971:
967:
963:
960:
957:
953:
949:
946:
943:
939:
935:
931:
930:Pristinamycin
928:
927:
925:
923:
919:
913:
910:
908:
905:
903:
900:
899:
897:
895:
891:
885:
884:Solithromycin
882:
880:
877:
875:
874:Telithromycin
872:
871:
869:
867:
863:
857:
854:
852:
849:
847:
846:Tulathromycin
844:
842:
839:
837:
834:
832:
829:
827:
826:Telithromycin
824:
822:
819:
817:
816:Solithromycin
814:
812:
811:Roxithromycin
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
776:Gamithromycin
774:
772:
769:
767:
764:
762:
761:Dirithromycin
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
733:
731:
729:
725:
722:
719:
714:
704:
701:
699:
698:Thiamphenicol
696:
694:
693:Azidamfenicol
691:
689:
686:
685:
683:
681:
677:
674:
672:
668:
662:
659:
657:
654:
652:
649:
647:
644:
642:
639:
637:
634:
632:
629:
628:
626:
623:
618:
617:Oxazolidinone
614:
611:
609:
605:
591:
588:
587:
585:
583:
579:
573:
570:
568:
565:
563:
560:
558:
555:
553:
550:
548:
545:
543:
540:
538:
535:
533:
530:
528:
525:
523:
520:
518:
515:
513:
510:
508:
505:
503:
500:
499:
497:
495:Tetracyclines
493:
490:
487:
482:
478:
468:
465:
464:
462:
458:
452:
449:
447:
444:
443:
438:
435:
433:
430:
428:
425:
423:
420:
418:
415:
414:
413:
410:
409:
407:
404:
403:
397:
391:
388:
386:
383:
381:
378:
376:
373:
371:
370:Spectinomycin
368:
365:
361:
358:
357:
352:
349:
347:
344:
342:
339:
337:
334:
333:
332:
329:
328:
323:
320:
318:
315:
313:
310:
309:
308:
305:
304:
301:
298:
296:
293:
292:
290:
287:
286:
280:
277:
274:
269:
265:
262:
260:
256:
251:
247:
243:
239:
235:
231:
227:
220:
215:
213:
208:
206:
201:
200:
197:
187:
181:
178:
173:
169:
166:(4): 409–13.
165:
161:
156:
148:
145:
138:
136:
134:
133:liver failure
130:
126:
125:telithromycin
122:
118:
110:
108:
106:
105:solithromycin
102:
98:
94:
93:telithromycin
89:
86:
82:
77:
75:
71:
67:
64:group in the
63:
59:
56:sugar with a
55:
51:
47:
43:
39:
33:
32:Telithromycin
29:
19:
970:Quinupristin
966:Dalfopristin
894:Lincosamides
865:
831:Tildipirosin
801:Oleandomycin
766:Erythromycin
736:Azithromycin
572:Tetracycline
547:Omadacycline
532:Meclocycline
522:Eravacycline
512:Clomocycline
427:Micronomicin
400:
375:Hygromycin B
364:+loteprednol
322:Ribostamycin
295:Streptomycin
285:Streptomyces
283:
185:
180:
163:
159:
147:
114:
111:Medical uses
96:
90:
85:azithromycin
78:
50:erythromycin
37:
36:
1020:from market
956:Linopristin
902:Clindamycin
879:Cethromycin
806:Rokitamycin
791:Midecamycin
786:Kitasamycin
703:Florfenicol
680:Amphenicols
624:inhibitors)
590:Tigecycline
567:Sarecycline
542:Minocycline
537:Metacycline
527:Lymecycline
502:Doxycycline
346:Bekanamycin
317:Paromomycin
275:inhibitors)
101:cethromycin
42:antibiotics
952:Flopristin
912:Pirlimycin
907:Lincomycin
856:Tylvalosin
836:Tilmicosin
821:Spiramycin
796:Miocamycin
751:Carrimycin
746:Carbomycin
728:Macrolides
651:Ranbezolid
631:Eperezolid
622:initiation
451:Astromicin
446:Verdamicin
437:Isepamicin
432:Plazomicin
417:Netilmicin
412:Gentamicin
360:Tobramycin
312:Framycetin
273:initiation
139:References
58:keto-group
1030:Phase III
1018:Withdrawn
866:Ketolides
781:Josamycin
741:Boromycin
661:Tedizolid
656:Sutezolid
646:Radezolid
641:Posizolid
636:Linezolid
467:Butirosin
422:Sisomicin
385:Apramycin
380:Totomycin
351:Dibekacin
341:Arbekacin
331:Kanamycin
129:hepatitis
62:carbamate
54:cladinose
46:macrolide
38:Ketolides
18:Ketolides
1051:Category
488:binding)
399:-micin (
336:Amikacin
307:Neomycin
282:-mycin (
172:15303785
119:. Other
74:ribosome
851:Tylosin
66:lactone
1013:WHO-EM
948:NXL103
250:QJ01XQ
170:
716:MLS (
460:other
228:that
97:Ketek
486:tRNA
246:J01G
242:J01F
238:J01B
234:J01A
168:PMID
131:and
103:and
40:are
942:IIB
938:IIA
608:50S
259:30S
1053::
1026::
990:S1
968:,
954:,
940:,
936:,
934:IA
248:,
244:,
240:,
236:,
162:.
158:.
135:.
107:.
992:)
988:(
972:)
964:(
958:)
950:(
944:)
932:(
720:)
620:(
484:(
405:)
366:)
362:(
288:)
271:(
252:)
232:(
218:e
211:t
204:v
174:.
164:3
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
