378:
833:
370:
pathways but also when cells process alcohol. His lab showed that mammals use a two-tier protection mechanism to counteract aldehydes, consisting of (1) enzymatic clearance of aldehydes by aldehyde dehydrogenases and (2) the
Fanconi DNA repair pathway (see Figure). Although Fanconi anaemia is a very rare condition, genetic deficiency of this two-tier protection mechanism is actually very common in man: up to 500 million Asians are deficient in first tier protection due to mutations in the gene
45:
369:
Patel's research on the
Fanconi pathway has provided key molecular insights into how cells remove DNA crosslinks and, most recently, his lab discovered that reactive aldehydes are the likely natural agents that produce them. Aldehydes are ubiquitous metabolites, arising not only from many metabolic
334:
After his PhD, Patel was awarded an MRC Clinician
Scientist Fellowship and started working with A. Venkitaraman (1995–1998) where he contributed to the discovery that the BRCA2 protein functions in repairing damaged DNA. Patel eventually joined the LMB as a tenure track group leader (1999–2007) and
942:
Carpten, J. D.; Faber, A. L.; Horn, C; Donoho, G. P.; Briggs, S. L.; Robbins, C. M.; Hostetter, G; Boguslawski, S; Moses, T. Y.; Savage, S; Uhlik, M; Lin, A; Du, J; Qian, Y. W.; Zeckner, D. J.; Tucker-Kellogg, G; Touchman, J; Patel, K; Mousses, S; Bittner, M; Schevitz, R; Lai, M. H.; Blanchard, K.
398:(1996–2000). He was also awarded the Max Perutz Prize for his PhD research at the LMB (1994), a prize from the Children with Cancer Research Fund for breakthroughs into the causes of childhood leukaemia (2005) and the Award of Merit from the Fanconi Anemia Research Fund. In 2013, Patel was elected
349:
Patel's research is mainly concerned with how living cells repair DNA crosslinks. These lesions cause the two opposing strands of DNA to be covalently bound together. Such crosslinks are lethal to cells since they would prevent DNA from being copied
34:
335:
was later on promoted to tenured principal investigator at the LMB (2007–2020). He was appointed professor of
Molecular Medicine and Stem Cell Genomics in 2017. He also served on the Life Sciences jury for the
450:
Patel derived the most pleasure when he received was a lifetime achievement award from the
Fanconi Anemia research fund – a charity set up by the families of those effected by this devastating illness.
1714:
303:, Kenya. His early education took place in his home country at Hospital Hill Primary School and Banda Preparatory School. In 1976, Patel left Kenya to continue his secondary education at
1053:
701:
1075:
Langevin, Frédéric; Crossan, Gerry P.; Rosado, Ivan V.; Arends, Mark J.; Patel, Ketan J. (2011). "Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice".
1362:
407:
780:
Crossan, G. P.; Van Der Weyden, L; Rosado, I. V.; Langevin, F; Gaillard, P. H.; McIntyre, R. E.; Sanger Mouse
Genetics, Project; Gallagher, F; Kettunen, M. I.; Lewis, D. Y.;
561:
Patel, K.J.; Neuberger, M.S. (1993). "Antigen presentation by the B cell antigen receptor is driven by the αβ sheath and occurs independently of its cytoplasmic tyrosines".
1724:
1269:
1734:
366:. This devastating inherited illness leads to congenital defects, progressive loss of blood production and an enormous lifetime risk of certain cancers.
343:
277:
177:
403:
281:
30:
377:
613:
1719:
395:
675:
1309:
326:(1989–1993). He completed a PhD in which he conducted research to understand the role the membrane bound form of the antibody molecule.
192:
1345:
1126:
Rosado, I. V.; Patel, KJ (2011). "Formaldehyde catabolism is essential in cells deficient for the
Fanconi anemia DNA repair pathway".
1169:
Garaycoechea, J. I.; Patel, KJ (2012). "Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function".
1287:
323:
284:
362:), but they also must arise naturally since individuals carrying a genetic defect in crosslink repair suffer from the illness
280:
and the MRC Molecular
Haematology Unit at the University of Oxford. Until 2020 he was a tenured principal investigator at the
1591:
426:
attrition and cancer in humans. Patel has unveiled the primary role of the
Fanconi pathway in resolving DNA damage caused by
446:
of action of the pathway and thrown light on its roles in preserving blood stem cells as well as in protection from cancer.
1045:
693:
1273:
1354:
26:
1556:
311:
and the
University of London (1980–1985) where he qualified as a doctor with distinctions in Medicine and Surgery.
406:(FMedSci). In 2015, he was elected fellow of the Royal Society of London (FRS). His certificate for election to
1536:
1526:
1401:
654:
182:
118:
832:
1709:
1501:
1338:
1019:
1648:
943:
L.; Thomas, J. E. (2007). "A transforming mutation in the pleckstrin homology domain of AKT1 in cancer".
893:; Yu, V. P.; Lee, H; Corcoran, A; Thistlethwaite, F. C.; Evans, M. J.; Colledge, W. H.; Friedman, L. S.;
1683:
1729:
1178:
952:
738:
187:
112:
623:
1396:
790:"Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia"
308:
304:
99:
1606:
1481:
1202:
1151:
1108:
976:
898:
762:
594:
496:
315:
1516:
679:
246:
1323:
1313:
643:
471:
Joenje, H; Patel, K. J. (2001). "The emerging genetic and molecular basis of Fanconi anaemia".
1688:
1586:
1476:
1446:
1421:
1416:
1331:
1251:
1194:
1143:
1100:
1092:
1001:
968:
924:
869:
821:
754:
729:
649:
586:
578:
540:
488:
443:
355:
319:
225:
44:
519:"The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair"
1561:
1496:
1466:
1456:
1391:
1241:
1233:
1186:
1135:
1084:
995:
960:
914:
859:
811:
803:
746:
570:
530:
480:
220:
208:
155:
614:"Michael Neuberger obituary: Biochemist who discovered how antibodies are greatly improved"
1673:
1658:
1596:
1551:
1486:
1461:
1441:
1436:
794:
399:
391:
363:
351:
160:
1222:"Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen"
1182:
956:
742:
1678:
1571:
1546:
1491:
1406:
1246:
1221:
816:
789:
415:
919:
902:
1703:
1653:
1601:
1531:
1471:
1386:
1358:
1295:
1291:
1112:
781:
766:
598:
574:
336:
1155:
500:
1663:
1643:
1622:
1581:
1576:
1566:
1511:
1506:
1431:
1411:
1376:
1206:
980:
894:
618:
661:
517:
Niedzwiedz, W; Mosedale, G; Johnson, M; Ong, C. Y.; Pace, P; Patel, K. J. (2004).
1237:
727:(2010). "Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway".
535:
518:
1627:
1541:
1451:
1426:
132:
1668:
1020:"Senior Academic Promotions, 1 October 2017 exercise: Appointments and titles"
431:
419:
1096:
582:
1381:
1005:
750:
723:
Pace, P; Mosedale, G; Hodskinson, M. R.; Rosado, I. V.; Sivasubramaniam, M;
423:
359:
1255:
1198:
1147:
1104:
972:
873:
825:
758:
544:
492:
928:
590:
427:
1190:
1088:
964:
439:
300:
296:
63:
1139:
484:
202:
81:
864:
847:
358:). DNA crosslinks are caused by numerous anti-cancer drugs (such as
346:
and the MRC Molecular Haematology Unit at the University of Oxford.
807:
435:
371:
67:
1327:
422:. Deficiencies in this pathway lead to defective development,
318:
but also was awarded an MRC training fellowship to work with
307:
in Wiltshire. He subsequently went to medical school at the
276:
is a British–Kenyan scientist who is Director of the MRC
1046:"MRC Molecular Haematology Unit appoints new Director"
694:"MRC Molecular Haematology Unit appoints new Director"
1272:. London: Academy of Medical Sciences. Archived from
1636:
1615:
1369:
997:
Antigen presentation by the B cell antigen receptor
342:In 2020 Patel was appointed as Director of the MRC
235:
219:
209:
Antigen presentation by the B cell antigen receptor
201:
169:
145:
128:
105:
93:
74:
54:
20:
642:
1715:Fellows of Gonville and Caius College, Cambridge
412:
657: ed.). Oxford: A & C Black.
381:Two-tier protection against reactive aldehydes
1339:
442:). He has also advanced our knowledge of the
414:KJ Patel has made seminal discoveries on the
8:
1312:. London: The Royal Society. Archived from
556:
554:
1346:
1332:
1324:
354:) or for the genes it carries to be read (
344:Weatherall Institute of Molecular Medicine
278:Weatherall Institute of Molecular Medicine
178:Weatherall Institute of Molecular Medicine
43:
17:
1245:
918:
863:
815:
678:. University of Cambridge. Archived from
637:
635:
633:
534:
408:Fellow of the Royal Society (FRS) in 2015
404:Fellow of the Academy of Medical Sciences
885:
883:
512:
510:
466:
464:
376:
1000:(PhD thesis). University of Cambridge.
460:
1725:People educated at Marlborough College
1056:from the original on 23 September 2020
848:"Metabolism: Alcohol, DNA and disease"
704:from the original on 23 September 2020
396:Gonville and Caius College, Cambridge
285:Laboratory of Molecular Biology (LMB)
7:
903:"Involvement of Brca2 in DNA repair"
193:MRC Laboratory of Molecular Biology
1735:British people of Gujarati descent
612:Ketan J. Patel (1 December 2013).
14:
1220:Pontel, L. B.; Patel, KJ (2015).
994:Patel, Ketan Jayakrishna (1994).
430:(whether generated by endogenous
831:
784:; Arends, M. J.; Adams, D. J.;
438:of ingested substances such as
324:Laboratory of Molecular Biology
314:Patel originally trained as a
299:Indian origin and was born in
282:Medical Research Council (MRC)
1:
1024:Cambridge University Reporter
920:10.1016/s1097-2765(00)80035-0
644:"PATEL, Dr Ketan Jayakrishna"
1720:Fellows of the Royal Society
1310:"Dr Ketan Patel FMedSci FRS"
1270:"Dr Ketan Patel FRS FMedSci"
1238:10.1016/j.molcel.2015.08.020
662:UK public library membership
575:10.1016/0092-8674(93)90473-4
536:10.1016/j.molcel.2004.08.009
1751:
653:. Vol. 2016 (online
231:
138:
42:
1050:Medical Research Council
698:Medical Research Council
291:Education and early life
751:10.1126/science.1192277
655:Oxford University Press
473:Nature Reviews Genetics
274:Ketan Jayakrishna Patel
183:John Radcliffe Hospital
119:University of Cambridge
59:Ketan Jayakrishna Patel
448:
382:
390:Patel was elected to
380:
1298:on 17 November 2015.
1288:"Dr Ketan Patel FRS"
188:University of Oxford
113:University of London
1191:10.1038/nature11368
1183:2012Natur.489..571G
1128:Nat Struct Mol Biol
1089:10.1038/nature10192
965:10.1038/nature05933
957:2007Natur.448..439C
899:Venkitaraman, A. R.
743:2010Sci...329..219P
676:"Ketan J. Patel CV"
444:molecular mechanism
330:Career and Research
309:Royal Free Hospital
305:Marlborough College
100:Marlborough College
846:Joenje, H (2011).
386:Awards and honours
383:
339:in 2018 and 2019.
316:gastroenterologist
1697:
1696:
1587:Natalie Strynadka
1477:Zoubin Ghahramani
1177:(7417): 571–575.
1140:10.1038/nsmb.2173
660:(Subscription or
626:on 27 March 2015.
356:DNA transcription
320:Michael Neuberger
271:
270:
226:Michael Neuberger
140:Scientific career
1742:
1467:Alison Etheridge
1457:A. W. F. Edwards
1348:
1341:
1334:
1325:
1318:
1317:
1306:
1300:
1299:
1294:. Archived from
1284:
1278:
1277:
1266:
1260:
1259:
1249:
1217:
1211:
1210:
1166:
1160:
1159:
1123:
1117:
1116:
1072:
1066:
1065:
1063:
1061:
1052:. 1 April 2020.
1042:
1036:
1035:
1033:
1031:
1016:
1010:
1009:
991:
985:
984:
951:(7152): 439–44.
939:
933:
932:
922:
887:
878:
877:
867:
843:
837:
836:
835:
829:
819:
777:
771:
770:
737:(5988): 219–23.
720:
714:
713:
711:
709:
700:. 1 April 2020.
690:
684:
683:
682:on 21 July 2013.
672:
666:
665:
658:
646:
639:
628:
627:
622:. Archived from
609:
603:
602:
558:
549:
548:
538:
514:
505:
504:
485:10.1038/35076590
468:
265:
262:
260:
258:
256:
254:
252:
250:
248:
221:Doctoral advisor
215:
156:Medical genetics
47:
37:
18:
1750:
1749:
1745:
1744:
1743:
1741:
1740:
1739:
1700:
1699:
1698:
1693:
1632:
1611:
1517:Gero Miesenböck
1487:Michael Hausser
1462:Yvonne Elsworth
1442:Philip Donoghue
1437:Annette Dolphin
1365:
1352:
1322:
1321:
1308:
1307:
1303:
1286:
1285:
1281:
1276:on 12 May 2015.
1268:
1267:
1263:
1219:
1218:
1214:
1168:
1167:
1163:
1125:
1124:
1120:
1083:(7354): 53–58.
1074:
1073:
1069:
1059:
1057:
1044:
1043:
1039:
1029:
1027:
1018:
1017:
1013:
993:
992:
988:
941:
940:
936:
889:
888:
881:
865:10.1038/475045a
845:
844:
840:
830:
795:Nature Genetics
779:
778:
774:
722:
721:
717:
707:
705:
692:
691:
687:
674:
673:
669:
659:
641:
640:
631:
611:
610:
606:
560:
559:
552:
516:
515:
508:
470:
469:
462:
457:
416:Fanconi pathway
400:EMBO Membership
392:Research Fellow
388:
364:Fanconi anaemia
352:DNA replication
332:
322:FRS at the MRC
293:
267:
245:
213:
197:
165:
161:Fanconi anaemia
124:
106:Alma mater
98:
89:
70:
61:
60:
50:
38:
25:
23:
12:
11:
5:
1748:
1746:
1738:
1737:
1732:
1727:
1722:
1717:
1712:
1702:
1701:
1695:
1694:
1692:
1691:
1686:
1684:William Miller
1681:
1676:
1671:
1666:
1661:
1656:
1651:
1646:
1640:
1638:
1634:
1633:
1631:
1630:
1625:
1619:
1617:
1613:
1612:
1610:
1609:
1604:
1599:
1594:
1592:Richard Thomas
1589:
1584:
1579:
1574:
1569:
1564:
1559:
1557:John Robertson
1554:
1549:
1544:
1539:
1534:
1529:
1527:David Phillips
1524:
1519:
1514:
1509:
1504:
1502:Andy Mackenzie
1499:
1494:
1492:Laurence Hurst
1489:
1484:
1479:
1474:
1469:
1464:
1459:
1454:
1449:
1447:Daniel Drucker
1444:
1439:
1434:
1429:
1424:
1422:Stephen Cusack
1419:
1414:
1409:
1407:Clifford Cocks
1404:
1399:
1394:
1389:
1384:
1379:
1373:
1371:
1367:
1366:
1353:
1351:
1350:
1343:
1336:
1328:
1320:
1319:
1316:on 2 May 2015.
1301:
1279:
1261:
1232:(1): 177–188.
1212:
1161:
1134:(12): 1432–4.
1118:
1067:
1037:
1026:. 26 July 2017
1011:
986:
934:
907:Molecular Cell
879:
858:(7354): 45–6.
838:
808:10.1038/ng.752
772:
715:
685:
667:
629:
604:
569:(5): 939–946.
550:
523:Molecular Cell
506:
459:
458:
456:
453:
387:
384:
331:
328:
292:
289:
269:
268:
257:/group-leaders
243:
242:
239:
237:
233:
232:
229:
228:
223:
217:
216:
205:
199:
198:
196:
195:
190:
185:
180:
173:
171:
167:
166:
164:
163:
158:
153:
149:
147:
143:
142:
136:
135:
130:
126:
125:
123:
122:
116:
109:
107:
103:
102:
95:
91:
90:
88:
87:
84:
78:
76:
72:
71:
62:
58:
56:
52:
51:
48:
40:
39:
24:
21:
13:
10:
9:
6:
4:
3:
2:
1747:
1736:
1733:
1731:
1728:
1726:
1723:
1721:
1718:
1716:
1713:
1711:
1710:Living people
1708:
1707:
1705:
1690:
1687:
1685:
1682:
1680:
1677:
1675:
1674:Sue Lindquist
1672:
1670:
1667:
1665:
1662:
1660:
1657:
1655:
1652:
1650:
1649:Zdeněk Bažant
1647:
1645:
1642:
1641:
1639:
1635:
1629:
1626:
1624:
1621:
1620:
1618:
1614:
1608:
1605:
1603:
1602:Frank Uhlmann
1600:
1598:
1595:
1593:
1590:
1588:
1585:
1583:
1580:
1578:
1575:
1573:
1570:
1568:
1565:
1563:
1562:Roger Sheldon
1560:
1558:
1555:
1553:
1550:
1548:
1545:
1543:
1540:
1538:
1535:
1533:
1532:Jonathan Pila
1530:
1528:
1525:
1523:
1520:
1518:
1515:
1513:
1510:
1508:
1505:
1503:
1500:
1498:
1497:Jane Langdale
1495:
1493:
1490:
1488:
1485:
1483:
1480:
1478:
1475:
1473:
1472:Jeremy Farrar
1470:
1468:
1465:
1463:
1460:
1458:
1455:
1453:
1450:
1448:
1445:
1443:
1440:
1438:
1435:
1433:
1430:
1428:
1425:
1423:
1420:
1418:
1415:
1413:
1410:
1408:
1405:
1403:
1400:
1398:
1397:Stephen Brown
1395:
1393:
1390:
1388:
1387:Allan Balmain
1385:
1383:
1380:
1378:
1375:
1374:
1372:
1368:
1364:
1360:
1359:Royal Society
1356:
1349:
1344:
1342:
1337:
1335:
1330:
1329:
1326:
1315:
1311:
1305:
1302:
1297:
1293:
1292:Royal Society
1289:
1283:
1280:
1275:
1271:
1265:
1262:
1257:
1253:
1248:
1243:
1239:
1235:
1231:
1227:
1223:
1216:
1213:
1208:
1204:
1200:
1196:
1192:
1188:
1184:
1180:
1176:
1172:
1165:
1162:
1157:
1153:
1149:
1145:
1141:
1137:
1133:
1129:
1122:
1119:
1114:
1110:
1106:
1102:
1098:
1094:
1090:
1086:
1082:
1078:
1071:
1068:
1055:
1051:
1047:
1041:
1038:
1025:
1021:
1015:
1012:
1007:
1003:
999:
998:
990:
987:
982:
978:
974:
970:
966:
962:
958:
954:
950:
946:
938:
935:
930:
926:
921:
916:
913:(3): 347–57.
912:
908:
904:
900:
896:
895:Ponder, B. A.
892:
886:
884:
880:
875:
871:
866:
861:
857:
853:
849:
842:
839:
834:
827:
823:
818:
813:
809:
805:
802:(2): 147–52.
801:
797:
796:
791:
787:
783:
776:
773:
768:
764:
760:
756:
752:
748:
744:
740:
736:
732:
731:
726:
719:
716:
703:
699:
695:
689:
686:
681:
677:
671:
668:
663:
656:
652:
651:
645:
638:
636:
634:
630:
625:
621:
620:
615:
608:
605:
600:
596:
592:
588:
584:
580:
576:
572:
568:
564:
557:
555:
551:
546:
542:
537:
532:
529:(4): 607–20.
528:
524:
520:
513:
511:
507:
502:
498:
494:
490:
486:
482:
479:(6): 446–57.
478:
474:
467:
465:
461:
454:
452:
447:
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1452:James Dyson
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