1284:
1263:
1353:
1381:
313:
1140:
290:
187:
212:
1283:
2198:
319:
218:
36:
2183:
1369:
1380:
1352:
1262:
1895:
Sonnenblick A, Francis PA, Azim HA, de
Azambuja E, Nordenskjöld B, Gutiérez J, Quinaux E, Mastropasqua MG, Ameye L, Anderson M, Lluch A, Gnant M, Goldhirsch A, Di Leo A, Barnadas A, Cortes-Funes H, Piccart M, Crown J (2015). "Final 10-year results of the Breast International Group 2-98 phase III
1289:
Counting positive versus negative nuclei with Ki-67 labeling, in this case in a neuroendocrine tumor of the small intestine. To count as positive, a nucleus should be at least half within the field of view, be large enough, and not be located in the stroma. Otherwise, even weakly positive nuclei
1256:. One of its primary advantages over the original Ki-67 antibody (and the reason why it has essentially supplanted the original antibody for clinical use) is that it can be used on formalin-fixed paraffin-embedded sections, after heat-mediated antigen retrieval (see next section below).
1207:). Cellular content of Ki-67 protein markedly increases during cell progression through S phase of the cell cycle. In breast cancer Ki67 identifies a high proliferative subset of patients with ER-positive breast cancer who derive greater benefit from adjuvant chemotherapy.
62:
1130:
transcription. Inactivation of antigen KI-67 leads to inhibition of ribosomal RNA synthesis, but does not significantly affect cell proliferation in vivo: Ki-67 mutant mice developed normally and cells lacking Ki-67 proliferated efficiently.
1509:
Schonk DM, Kuijpers HJ, van Drunen E, van Dalen CH, Geurts van Kessel AH, Verheijen R, Ramaekers FC (October 1989). "Assignment of the gene(s) involved in the expression of the proliferation-related Ki-67 antigen to human chromosome 10".
1251:
Ki-67 and MIB-1 monoclonal antibodies are directed against different epitopes of the same proliferation-related antigen. Ki-67 and MIB-1 may be used on fixed sections. MIB-1 is used in clinical applications to determine the
1966:
Bánkfalvi A (November 2000). "Comparative methodological analysis of erbB-2/HER-2 gene dosage, chromosomal copy number and protein overexpression in breast carcinoma tissues for diagnostic use".
1848:"Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry"
1556:
Bullwinkel J, Baron-Lühr B, Lüdemann A, Wohlenberg C, Gerdes J, Scholzen T (March 2006). "Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells".
1358:
Immunofluorescent antibody staining against neurofilament (green) and Ki-67 (red) in a mouse embryo 12.5 days after fertilization. The proliferating cells are in the ventricular zone in the
326:
225:
1390:(green) and DNA (blue) in HeLa cells. Dividing cells show strong Ki-67 staining in cell nuclei while all cells contain large amounts of tubulin, the major component of
2009:
Gerdes J, Schwab U, Lemke H, Stein H (1983). "Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation".
1799:
Bruno S, Darzynkiewicz Z (January 1992). "Cell cycle dependent expression and stability of the nuclear protein detected by Ki-67 antibody in HL-60 cells".
823:
2197:
804:
148:
1243:. For these types of tumors, the prognostic value for survival and tumor recurrence have repeatedly been proven in uni- and multivariate analysis.
2226:
2162:
1477:
1459:
1031:
312:
1712:
1038:
2182:
1896:
trial and the role of Ki67 in predicting benefit of adjuvant docetaxel in patients with oestrogen receptor positive breast cancer".
289:
1495:
1648:
Sobecki M, Mrouj K, Camasses A, Parisis N, Nicolas E, Llères D, Gerbe F, Prieto S, Krasinska L, David A, others (Mar 6, 2016).
1446:
1425:
211:
186:
1931:
Yerushalmi R, Woods R, Ravdin PM, Hayes MM, Gelmon KA (2010). "Ki67 in breast cancer: prognostic and predictive potential".
1442:
59:
1421:
1215:
Ki-67 is an excellent marker to determine the growth fraction of a given cell population. The fraction of Ki-67-positive
128:
1742:
Cuylen S, Blaukopf C, Politi AZ, Müller-Reichert T, Neumann B, Poser I, Ellenberg J, Hyman AA, Gerlich DW (July 2016).
1368:
1321:
325:
224:
318:
217:
2155:
2108:
1139:
868:
136:
849:
2054:"Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins"
200:
2148:
1755:
1240:
1164:
115:
2236:
1395:
1014:
989:
963:
938:
1601:"Chromophore-assisted light inactivation of pKi-67 leads to inhibition of ribosomal RNA synthesis"
2083:
2034:
1991:
1824:
1724:
1581:
1535:
1228:
1168:
1123:
160:
993:
942:
1272:, with cancer nuclei being stained (brown). There is tumor cell positivity in 70% of the cells:
2231:
2120:
2075:
2026:
1983:
1948:
1913:
1877:
1816:
1781:
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1681:
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1527:
1107:
108:
52:
2065:
2018:
1975:
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1905:
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1305:
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405:
336:
280:
235:
17:
156:
380:
2114:
2104:
1236:
1759:
1699:
Scholzen T, Gerdes J (March 2000). "The Ki-67 protein: from the known and the unknown".
1872:
1847:
1812:
1776:
1743:
1676:
1649:
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1600:
35:
1944:
738:
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723:
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621:
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611:
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601:
596:
2220:
2129:
2070:
2053:
1979:
1616:
1269:
1127:
583:
1995:
1828:
1728:
1585:
1539:
2087:
2038:
1391:
1180:
1148:
398:
177:
140:
164:
1482:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1464:
National Center for
Biotechnology Information, U.S. National Library of Medicine
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481:
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541:
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263:
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152:
2079:
2052:
Kametaka A, Takagi M, Hayakawa T, Haraguchi T, Hiraoka Y, Yoneda Y (2002).
2022:
1987:
1952:
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1785:
1720:
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1634:
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1078:
1073:
1713:
10.1002/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9
1340:- Proliferating Cell Nuclear Antigen, expressed during the DNA synthesis.
1301:
1062:
913:
894:
1767:
1666:
2134:
2124:
1744:"Ki-67 acts as a biological surfactant to disperse mitotic chromosomes"
1523:
1387:
1184:
1176:
1102:
880:
835:
1569:
1312:, Germany) and the number of the original clone in the 96-well plate.
85:
81:
1300:
The Ki-67 protein was originally defined by the prototype monoclonal
1224:
1046:
790:
1216:
1138:
1304:
Ki-67, which was generated by immunizing mice with nuclei of the
753:
749:
2206:: The solution structure of the Ki67FHA/hNIFK(226-269)3P complex
1650:"The cell proliferation antigen Ki-67 organises heterochromatin"
1337:
1325:
1309:
1111:
132:
2144:
2140:
1496:"Entrez Gene: Antigen identified by monoclonal antibody Ki-67"
1599:
Rahmanzadeh R, Hüttmann G, Gerdes J, Scholzen T (June 2007).
1308:
cell line L428. The name is derived from the city of origin (
1203:, and mitosis), but is absent in resting (quiescent) cells (G
1163:) is a cellular marker for proliferation, and can be used in
2119:
Overview of all the structural information available in the
1191:. Ki-67 protein is present during all active phases of the
1122:
Antigen KI-67 is a nuclear protein that is associated with
119:, marker of proliferation Ki-67, KIA, MIB-, MIB-1, PPP1R105
388:
1187:
most of the protein is relocated to the surface of the
2115:
http://www.pathologyoutlines.com/topic/stainski67.html
553:
1114:(antigen identified by monoclonal antibody Ki-67).
1007:
982:
956:
931:
1438:
1436:
1434:
1417:
1415:
1413:
1394:. Antibodies, cell staining and image courtesy of
1223:) is often correlated with the clinical course of
335:
234:
1227:. The best-studied examples in this context are
1551:
1549:
1443:GRCm38: Ensembl release 89: ENSMUSG00000031004
2191:: Solution Structure of human Ki67 FHA Domain
2156:
8:
2133:(Proliferation marker protein Ki-67) at the
1422:GRCh38: Ensembl release 89: ENSG00000148773
2163:
2149:
2141:
1842:Darzynkiewicz Z, Zhao H, Zhang S, Lee MY,
764:
579:
376:
275:
172:
70:
2107:at the U.S. National Library of Medicine
2069:
1871:
1775:
1675:
1665:
1624:
492:fetal liver hematopoietic progenitor cell
1101:(marker of proliferation Kiel 67), is a
2178:
1409:
1348:
1258:
1179:can be exclusively detected within the
1135:Use as a marker of proliferating cells
729:regulation of mitotic nuclear division
25:
1268:High Ki-67 expression in an invasive
340:
301:
296:
239:
198:
193:
7:
734:regulation of chromatin organization
719:regulation of chromosome segregation
694:response to organic cyclic compound
1813:10.1111/j.1365-2184.1992.tb01435.x
1374:Protein Ki-67 in human MCF-7 cells
1320:Ki-67 (protein) has been shown to
1004:
979:
953:
928:
904:
885:
859:
840:
814:
795:
558:
476:
414:
393:
14:
1167:. It is strictly associated with
1105:that in humans is encoded by the
23:Mammalian protein found in humans
2196:
2181:
2071:10.1046/j.1365-2443.2002.00596.x
1980:10.1046/j.1365-2559.2000.00984.x
1617:10.1111/j.1365-2184.2007.00433.x
1379:
1367:
1351:
1282:
1261:
324:
317:
311:
288:
223:
216:
210:
185:
34:
1701:Journal of Cellular Physiology
1151:with a high proliferative rate
658:chromosome, centromeric region
542:More reference expression data
1:
1945:10.1016/S1470-2045(09)70262-1
724:cell population proliferation
309:
208:
16:For the Japanese bomber, see
2227:Genes on human chromosome 10
709:hyaluronan metabolic process
458:stromal cell of endometrium
2253:
1910:10.1016/j.ejca.2015.03.018
1898:European Journal of Cancer
1362:and therefore colored red.
602:protein C-terminus binding
462:mucosa of transverse colon
15:
2176:
1478:"Mouse PubMed Reference:"
1460:"Human PubMed Reference:"
1077:
1072:
1068:
1061:
1045:
1039:Chr 7: 135.29 – 135.32 Mb
1032:Chr 10: 128.1 – 128.13 Mb
1026:
1011:
986:
975:
960:
935:
924:
911:
907:
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888:
879:
866:
862:
847:
843:
834:
821:
817:
802:
798:
789:
774:
767:
763:
747:
704:animal organ regeneration
689:cellular response to heat
582:
578:
566:
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552:
539:
488:
479:
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345:
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126:
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113:
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73:
56:
51:
46:
42:
33:
28:
2109:Medical Subject Headings
1864:10.18632/oncotarget.4149
450:tendon of biceps brachii
1296:Original Ki-67 antibody
1159:protein (also known as
2023:10.1002/ijc.2910310104
1846:, Zhang Z (May 2015).
1152:
1124:cellular proliferation
1386:Ki-67 protein (red),
1275:Ki-67 labelling index
1254:Ki-67 labelling index
1241:neuroendocrine tumors
1142:
699:DNA metabolic process
201:Chromosome 10 (human)
1933:The Lancet. Oncology
1221:Ki-67 labeling index
1165:immunohistochemistry
668:condensed chromosome
303:Chromosome 7 (mouse)
74:List of PDB id codes
47:Available structures
1768:10.1038/nature18610
1760:2016Natur.535..308C
1667:10.7554/eLife.13722
1396:EnCor Biotechnology
434:ganglionic eminence
1801:Cell Proliferation
1660:(e13722): e13722.
1524:10.1007/BF00285178
1290:count as positive.
1169:cell proliferation
1153:
869:ENSMUSG00000031004
682:Biological process
631:Cellular component
597:nucleotide binding
590:Molecular function
496:tibiofemoral joint
2214:
2213:
1570:10.1002/jcp.20494
1345:Additional images
1233:breast carcinomas
1211:Antibody labeling
1088:
1087:
1084:
1083:
1057:
1056:
1022:
1021:
1001:
1000:
971:
970:
950:
949:
920:
919:
901:
900:
875:
874:
856:
855:
830:
829:
811:
810:
759:
758:
574:
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570:
569:
548:
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535:
534:
473:
472:
438:bone marrow cells
371:
370:
270:
269:
165:MKI67 - orthologs
97:
96:
93:
92:
57:Ortholog search:
2244:
2200:
2185:
2165:
2158:
2151:
2142:
2092:
2091:
2073:
2049:
2043:
2042:
2006:
2000:
1999:
1963:
1957:
1956:
1928:
1922:
1921:
1892:
1886:
1885:
1875:
1858:(14): 11735–50.
1839:
1833:
1832:
1796:
1790:
1789:
1779:
1754:(7611): 308–12.
1739:
1733:
1732:
1696:
1690:
1689:
1679:
1669:
1645:
1639:
1638:
1628:
1596:
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1589:
1558:J. Cell. Physiol
1553:
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1474:
1468:
1467:
1456:
1450:
1440:
1429:
1419:
1383:
1371:
1355:
1306:Hodgkin lymphoma
1286:
1265:
1093:, also known as
1070:
1069:
1041:
1034:
1017:
1005:
996:
980:
976:RefSeq (protein)
966:
954:
945:
929:
905:
886:
860:
841:
815:
796:
765:
580:
559:
544:
528:efferent ductule
520:primitive streak
508:genital tubercle
484:
482:Top expressed in
477:
430:ventricular zone
422:
420:Top expressed in
415:
394:
377:
367:
354:
343:
328:
321:
315:
304:
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189:
173:
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118:
111:
88:
71:
65:
44:
43:
38:
26:
18:Mitsubishi Ki-67
2252:
2251:
2247:
2246:
2245:
2243:
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2217:
2216:
2215:
2210:
2207:
2201:
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2186:
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2101:
2096:
2095:
2064:(12): 1231–42.
2051:
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2008:
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1091:Antigen Kiel 67
1079:View/Edit Mouse
1074:View/Edit Human
1037:
1030:
1027:Location (UCSC)
1013:
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850:ENSG00000148773
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279:Gene location (
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176:Gene location (
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2099:External links
2097:
2094:
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2058:Genes to Cells
2044:
2011:Int. J. Cancer
2001:
1968:Histopathology
1958:
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1904:(12): 1481–9.
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2110:
2106:
2105:Ki-67+Antigen
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2102:
2098:
2089:
2085:
2081:
2077:
2072:
2067:
2063:
2059:
2055:
2048:
2045:
2040:
2036:
2032:
2028:
2024:
2020:
2016:
2012:
2005:
2002:
1997:
1993:
1989:
1985:
1981:
1977:
1973:
1969:
1962:
1959:
1954:
1950:
1946:
1942:
1939:(2): 174–83.
1938:
1934:
1927:
1924:
1919:
1915:
1911:
1907:
1903:
1899:
1891:
1888:
1883:
1879:
1874:
1869:
1865:
1861:
1857:
1853:
1849:
1845:
1838:
1835:
1830:
1826:
1822:
1818:
1814:
1810:
1806:
1802:
1795:
1792:
1787:
1783:
1778:
1773:
1769:
1765:
1761:
1757:
1753:
1749:
1745:
1738:
1735:
1730:
1726:
1722:
1718:
1714:
1710:
1707:(3): 311–22.
1706:
1702:
1695:
1692:
1687:
1683:
1678:
1673:
1668:
1663:
1659:
1655:
1651:
1644:
1641:
1636:
1632:
1627:
1622:
1618:
1614:
1611:(3): 422–30.
1610:
1606:
1602:
1595:
1592:
1587:
1583:
1579:
1575:
1571:
1567:
1564:(3): 624–35.
1563:
1559:
1552:
1550:
1546:
1541:
1537:
1533:
1529:
1525:
1521:
1517:
1513:
1505:
1502:
1497:
1491:
1488:
1483:
1479:
1473:
1470:
1465:
1461:
1455:
1452:
1448:
1444:
1439:
1437:
1435:
1431:
1427:
1423:
1418:
1416:
1414:
1410:
1403:
1397:
1393:
1389:
1382:
1377:
1370:
1365:
1361:
1354:
1349:
1344:
1339:
1336:
1335:
1331:
1329:
1327:
1323:
1315:
1313:
1311:
1307:
1303:
1295:
1285:
1280:
1276:
1271:
1270:breast cancer
1264:
1259:
1257:
1255:
1246:
1244:
1242:
1238:
1235:, as well as
1234:
1230:
1226:
1222:
1218:
1210:
1208:
1194:
1190:
1186:
1183:, whereas in
1182:
1178:
1174:
1170:
1166:
1162:
1158:
1150:
1146:
1141:
1134:
1132:
1129:
1128:ribosomal RNA
1125:
1117:
1115:
1113:
1110:
1109:
1104:
1100:
1096:
1092:
1080:
1075:
1071:
1067:
1064:
1060:
1053:
1051:
1048:
1044:
1040:
1036:
1033:
1029:
1025:
1018:
1016:
1010:
1006:
1003:
997:
995:
991:
985:
981:
978:
974:
967:
965:
959:
955:
952:
946:
944:
940:
934:
930:
927:
925:RefSeq (mRNA)
923:
916:
915:
910:
906:
903:
897:
896:
891:
887:
884:
882:
878:
871:
870:
865:
861:
858:
852:
851:
846:
842:
839:
837:
833:
826:
825:
820:
816:
813:
807:
806:
801:
797:
794:
792:
788:
785:
782:
780:
777:
773:
770:
766:
762:
755:
751:
746:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
686:
684:
681:
680:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
635:
633:
630:
629:
623:
620:
618:
615:
613:
610:
608:
605:
603:
600:
598:
595:
594:
592:
589:
588:
585:
584:Gene ontology
581:
577:
565:
560:
557:
555:
551:
543:
538:
527:
523:
519:
516:hair follicle
515:
511:
507:
503:
499:
495:
491:
490:
487:
483:
478:
475:
465:
461:
457:
453:
449:
445:
441:
437:
433:
429:
428:
425:
421:
416:
413:
412:
409:
407:
403:
401:
400:
396:
395:
392:
390:
386:
382:
378:
374:
366:
361:
357:
353:
348:
338:
334:
327:
320:
314:
307:
299:
295:
291:
286:
282:
277:
273:
265:
260:
256:
252:
247:
237:
233:
226:
219:
213:
206:
202:
196:
192:
188:
183:
179:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
122:
117:
110:
105:
100:
89:
87:
83:
77:
72:
69:
68:
64:
61:
54:
50:
45:
41:
37:
32:
27:
19:
2203:
2188:
2128:
2061:
2057:
2047:
2017:(1): 13–20.
2014:
2010:
2004:
1974:(5): 411–9.
1971:
1967:
1961:
1936:
1932:
1926:
1901:
1897:
1890:
1855:
1851:
1837:
1807:(1): 31–40.
1804:
1800:
1794:
1751:
1747:
1737:
1704:
1700:
1694:
1657:
1653:
1643:
1608:
1604:
1594:
1561:
1557:
1518:(3): 297–9.
1515:
1511:
1504:
1490:
1481:
1472:
1463:
1454:
1392:microtubules
1319:
1316:Interactions
1299:
1274:
1253:
1250:
1231:, brain and
1220:
1214:
1181:cell nucleus
1175:, the Ki-67
1160:
1156:
1154:
1149:brain tumour
1121:
1106:
1098:
1094:
1090:
1089:
1015:NP_001074586
1012:
990:NP_001139438
987:
964:NM_001081117
961:
939:NM_001145966
936:
912:
893:
867:
848:
822:
803:
783:
778:
673:nuclear body
512:vas deferens
404:
397:
363:135,318,090
350:135,291,513
262:128,126,423
249:128,096,659
124:External IDs
79:
2171:PDB gallery
1605:Cell Prolif
1360:neural tube
1219:cells (the
1189:chromosomes
622:RNA binding
617:DNA binding
612:ATP binding
504:Paneth cell
500:human fetus
342:7|7 F3
102:Identifiers
2237:Cell cycle
2221:Categories
1852:Oncotarget
1512:Hum. Genet
1449:, May 2017
1428:, May 2017
1404:References
1193:cell cycle
1173:interphase
714:cell cycle
648:chromosome
408:(ortholog)
145:HomoloGene
1171:. During
994:NP_002408
943:NM_002417
769:Orthologs
653:nucleolus
638:cytoplasm
153:GeneCards
2232:Proteins
2080:12485163
1996:35267896
1988:11119122
1953:20152769
1918:26074397
1882:26059433
1829:37050410
1786:27362226
1729:22944989
1721:10653597
1686:26949251
1635:17531085
1586:22770145
1578:16206250
1540:32117144
1445:–
1424:–
1332:See also
1322:interact
1302:antibody
1229:prostate
1118:Function
1063:Wikidata
748:Sources:
643:membrane
466:testicle
2135:PDBe-KB
2125:UniProt
2088:6802841
2039:1764319
2031:6339421
1873:4494901
1821:1540682
1777:4947524
1756:Bibcode
1677:4841783
1626:6496591
1532:2571566
1447:Ensembl
1426:Ensembl
1388:tubulin
1185:mitosis
1177:antigen
1103:protein
881:UniProt
836:Ensembl
775:Species
754:QuickGO
739:meiosis
663:nucleus
383:pattern
241:10q26.2
109:Aliases
2130:P46013
2111:(MeSH)
2086:
2078:
2037:
2029:
1994:
1986:
1951:
1916:
1880:
1870:
1844:Lee EY
1827:
1819:
1784:
1774:
1748:Nature
1727:
1719:
1684:
1674:
1633:
1623:
1584:
1576:
1538:
1530:
1225:cancer
1199:, S, G
1143:Ki-67
1049:search
1047:PubMed
914:E9PVX6
895:P46013
791:Entrez
554:BioGPS
454:thymus
141:106035
133:176741
2084:S2CID
2035:S2CID
1992:S2CID
1825:S2CID
1725:S2CID
1654:eLife
1582:S2CID
1536:S2CID
1324:with
1277:= 70%
1247:MIB-1
1217:tumor
1161:MKI67
1157:Ki-67
1147:of a
1108:MKI67
1099:MKI67
1095:Ki-67
824:17345
784:Mouse
779:Human
750:Amigo
442:gonad
406:Mouse
399:Human
346:Start
281:Mouse
245:Start
178:Human
157:MKI67
116:MKI67
29:MKI67
2204:2aff
2189:1r21
2123:for
2076:PMID
2027:PMID
1984:PMID
1949:PMID
1914:PMID
1878:PMID
1817:PMID
1782:PMID
1717:PMID
1682:PMID
1631:PMID
1574:PMID
1528:PMID
1338:PCNA
1326:CBX3
1310:Kiel
1239:and
1155:The
1126:and
1112:gene
805:4288
389:Bgee
337:Band
298:Chr.
236:Band
195:Chr.
149:1814
129:OMIM
86:2AFF
82:1R21
63:RCSB
60:PDBe
2121:PDB
2066:doi
2019:doi
1976:doi
1941:doi
1906:doi
1868:PMC
1860:doi
1809:doi
1772:PMC
1764:doi
1752:535
1709:doi
1705:182
1672:PMC
1662:doi
1621:PMC
1613:doi
1566:doi
1562:206
1520:doi
1097:or
562:n/a
359:End
258:End
161:OMA
137:MGI
53:PDB
2223::
2127::
2082:.
2074:.
2060:.
2056:.
2033:.
2025:.
2015:31
2013:.
1990:.
1982:.
1972:37
1970:.
1947:.
1937:11
1935:.
1912:.
1902:51
1900:.
1876:.
1866:.
1854:.
1850:.
1823:.
1815:.
1805:25
1803:.
1780:.
1770:.
1762:.
1750:.
1746:.
1723:.
1715:.
1703:.
1680:.
1670:.
1656:.
1652:.
1629:.
1619:.
1609:40
1607:.
1603:.
1580:.
1572:.
1560:.
1548:^
1534:.
1526:.
1516:83
1514:.
1480:.
1462:.
1433:^
1412:^
1328:.
1195:(G
752:/
365:bp
352:bp
264:bp
251:bp
159:;
155::
151:;
147::
143:;
139::
135:;
131::
84:,
2164:e
2157:t
2150:v
2137:.
2090:.
2068::
2062:7
2041:.
2021::
1998:.
1978::
1955:.
1943::
1920:.
1908::
1884:.
1862::
1856:6
1831:.
1811::
1788:.
1766::
1758::
1731:.
1711::
1688:.
1664::
1658:5
1637:.
1615::
1588:.
1568::
1542:.
1522::
1498:.
1484:.
1466:.
1398:.
1205:0
1201:2
1197:1
283:)
180:)
163::
20:.
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