42:
1680:
451:
Factor VIII was first identified in the 1940s and became available as a medication in the 1960s. Recombinant factor VIII was first made in 1984 and approved for medical use in the United States in 1992. It is on the
509:
The cost of Factor VIII and similar clotting factors has been described as "highly expensive". The cost of the clotting factors is 80% of all medical costs for people with hemophilia. They are so expensive that
183:
1715:
1720:
346:
279:
138:
716:
946:
Biotechnology in blood transfusion: Proceedings of the
Twelfth Annual Symposium on Blood Transfusion, Groningen 1987, organized by the Red Cross Blood Bank Groningen-Drenthe
598:
75:
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1041:
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93:
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synthesized factor products, which now prevent nearly all forms of disease transmission during replacement therapy.
112:
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before purification methods were improved. In the early 1990s, pharmaceutical companies began to produce
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85:
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57:
982:
908:
1591:
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1153:
1145:
1095:
1063:
1023:
949:
811:
744:
942:"In vivo characteristics of rDNA Factor VIII: The impact for the future in hemophilia care"
770:
1684:
1611:
1368:
1364:
1360:
1276:
1263:
547:
541:
535:
493:
1158:
1133:
1027:
257:
1222:"Antihemophilic Factor (recombinant), Glycopegylated-exei Monograph for Professionals"
1086:
Nathwani AC, Davidoff AM, Tuddenham EG (October 2017). "Gene
Therapy for Hemophilia".
1694:
1511:
1506:
1464:
1306:
1149:
721:
1210:"Antihemophilic Factor (recombinant), Fc Fusion Protein Monograph for Professionals"
1640:
1496:
1479:
1430:
1386:
1267:
1198:"Antihemophilic Factor (Recombinant), Porcine Sequence Monograph for Professionals"
1115:
477:
437:
398:
151:
146:
877:
651:"Prescription medicines: registration of new chemical entities in Australia, 2014"
625:"Prescription medicines: registration of new chemical entities in Australia, 2016"
599:"Prescription medicines: registration of new chemical entities in Australia, 2017"
953:
1655:
1557:
1548:
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130:
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is safe for the fetus. A purified factor VIII concentrate is made from human
324:
1630:
1378:
1315:
1298:
489:
433:
421:
79:
33:
1167:
1107:
1060:
World Health
Organization model list of essential medicines: 21st list 2019
1645:
1572:
1543:
1416:
1411:
1232:
394:
107:
1068:
17:
1020:
Blood
Banking and Transfusion Medicine: Basic Principles & Practice
816:
514:
might be less expensive, especially for people with severe hemophilia.
41:
1624:
417:
1186:"Antihemophilic Factor (Recombinant) Monograph for Professionals"
677:"Prescription medicines and biologicals: TGA annual summary 2017"
448:
to factor VIII such that this medication becomes less effective.
376:
309:
218:
1236:
206:
102:
878:"Alphanate – Summary of Product Characteristics (SPC) – (eMC)"
485:
1134:"Gene therapy in hemophilia A: a cost-effectiveness analysis"
177:
416:
Side effects include skin flushing, shortness of breath,
1072:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
717:"Health Canada New Drug Authorizations: 2016 Highlights"
190:
913:
Queen
Victoria's Gene: Haemophilia and the Royal Family
454:
948:. Springer Science & Business Media. p. 224.
405:. Certain preparations may also be used in those with
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167:
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137:
122:
92:
74:
66:
56:
51:
853:. British Medical Association. 2015. p. 171.
484:often led to the transmission of diseases such as
1716:Drugs developed by Takeda Pharmaceutical Company
1081:
1079:
806:(2009). Stuart MC, Kouimtzi M, Hill SR (eds.).
1127:
1125:
1016:"Chapter 25 - Coagulation Factor Preparations"
810:. World Health Organization. pp. 259–60.
444:version is also available. People may develop
1721:World Health Organization essential medicines
1248:
8:
1088:Hematology/Oncology Clinics of North America
323:
256:
111:
32:
944:. In Sibinga CS, Das PC, Overby LR (eds.).
703:"Regulatory Decision Summary for Alphanate"
226:In general: ℞ (Prescription only)
1294:
1287:
1255:
1241:
1233:
1132:Machin N, Ragni MV, Smith KJ (July 2018).
798:
796:
794:
792:
550:, a recombinant antihemophilic factor VIII
544:, a recombinant antihemophilic factor VIII
538:, a recombinant antihemophilic factor VIII
532:, a recombinant antihemophilic factor VIII
526:, a recombinant antihemophilic factor VIII
393:is a medication used to treat and prevent
40:
1568:Tetragalacturonic acid hydroxymethylester
1157:
1067:
1022:. Elsevier Health Sciences. p. 353.
872:
870:
815:
851:British National Formulary : BNF 69
845:
843:
841:
839:
837:
1675:
560:
432:may occur. It is unclear if use during
681:Therapeutic Goods Administration (TGA)
655:Therapeutic Goods Administration (TGA)
629:Therapeutic Goods Administration (TGA)
603:Therapeutic Goods Administration (TGA)
322:
255:
31:
1062:. Geneva: World Health Organization.
480:byproduct into the blood stream of a
84:
7:
1044:from the original on 9 January 2017.
1003:from the original on 9 January 2017.
970:from the original on 9 January 2017.
929:from the original on 9 January 2017.
150:
981:Brownlee GG, Giangrande PL (2012).
888:from the original on 9 January 2017
579:from the original on 9 January 2017
1028:10.1016/B978-0-443-06981-9.50030-2
25:
1443:(II, VII, IX, X, protein C and S)
1678:
1150:10.1182/bloodadvances.2018021345
569:"Coagulation Factor VIII, Human"
1486:thrombopoietin receptor agonist
1441:Prothrombin complex concentrate
1701:Drugs not assigned an ATC code
1578:Hemostatic Powder Spray TC-325
983:"Clotting factors VIII and IX"
1:
1014:Zimring JC, Duncan A (2006).
954:10.1007/978-1-4613-1761-6_19
512:gene therapy for haemophilia
464:Factor VIII is delivered by
1737:
1373:Valoctocogene roxaparvovec
989:. Birkhäuser. p. 79.
411:slow injection into a vein
46:A depiction of factor VIII
1534:Absorbable gelatin sponge
1100:10.1016/j.hoc.2017.06.011
1056:World Health Organization
987:Recombinant Protein Drugs
804:World Health Organization
775:European Medicines Agency
749:European Medicines Agency
39:
1711:Drugs developed by Bayer
1383:Fidanacogene elaparvovec
808:WHO Model Formulary 2008
422:red blood cell breakdown
407:von Willebrand's disease
401:and other causes of low
62:Aafact, Kovaltry, others
1617:Aminomethylbenzoic acid
1018:. In Hillyer CD (ed.).
258:rurioctocog alfa pegol
1349:Damoctocog alfa pegol
985:. In Buckel P (ed.).
915:. The History Press.
524:Damoctocog alfa pegol
882:www.medicines.org.uk
466:intravenous infusion
500:Society and culture
476:This transfer of a
327:
260:
186:(Prescription only)
36:
27:Pharmaceutical drug
1563:Oxidized cellulose
1353:Efanesoctocog alfa
705:. 23 October 2014.
426:Allergic reactions
1666:
1665:
1636:Alfa1 antitrypsin
1607:Aminocaproic acid
1592:Antifibrinolytics
1586:
1585:
1522:
1521:
1357:Efmoroctocog alfa
1307:Phytomenadione (K
1144:(14): 1792–1798.
907:Potts DM (2011).
530:Efmoroctocog alfa
409:. It is given by
388:
387:
380:
321:
320:
313:
254:
253:
222:
210:
193:
181:
105:
16:(Redirected from
1728:
1706:Antihemorrhagics
1683:
1682:
1681:
1674:
1539:Calcium alginate
1295:
1288:
1277:Antihemorrhagics
1264:Antihemorrhagics
1257:
1250:
1243:
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1205:
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1083:
1074:
1073:
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1052:
1046:
1045:
1011:
1005:
1004:
978:
972:
971:
940:High KA (2012).
937:
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930:
904:
898:
897:
895:
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874:
865:
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832:
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751:. 8 January 2018
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1689:
1679:
1677:
1669:
1667:
1662:
1612:Tranexamic acid
1582:
1518:
1452:
1446:
1369:Turoctocog alfa
1365:Susoctocog alfa
1361:Moroctocog alfa
1331:
1324:
1319:
1310:
1279:
1271:
1261:
1220:
1208:
1196:
1184:
1181:
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725:. 14 March 2017
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548:Turoctocog alfa
542:Susoctocog alfa
536:Moroctocog alfa
520:
507:
502:
474:
462:
460:Available forms
397:in people with
384:
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1179:External links
1177:
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1138:Blood Advances
1121:
1094:(5): 853–868.
1075:
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1006:
996:978-3034883467
995:
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963:978-1461317616
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922:978-0752471969
921:
899:
866:
860:978-0857111562
859:
833:
826:
788:
777:. 2 March 2004
762:
745:"Adynovi EPAR"
736:
708:
694:
683:. 21 June 2022
668:
657:. 21 June 2022
642:
631:. 21 June 2022
616:
605:. 21 June 2022
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1512:Rafutrombopag
1510:
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1507:Lusutrombopag
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1465:Carbazochrome
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1438:combinations:
1436:
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823:
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795:
793:
789:
776:
772:
771:"Advate EPAR"
766:
763:
750:
746:
740:
737:
724:
723:
722:Health Canada
718:
712:
709:
704:
698:
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573:www.drugs.com
570:
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381: Rx-only
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331:Clinical data
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314: Rx-only
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264:Clinical data
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55:
52:Clinical data
50:
43:
38:
30:
19:
1641:C1-inhibitor
1623:
1599:
1497:Avatrombopag
1484:
1480:Fostamatinib
1437:
1431:Catridecacog
1422:I/Fibrinogen
1408:
1402:Eptacog alfa
1394:
1387:Nonacog alfa
1339:
1316:Menadione (K
1225:
1213:
1201:
1189:
1141:
1137:
1091:
1087:
1069:10665/325771
1059:
1050:
1019:
1009:
986:
976:
945:
935:
912:
902:
890:. Retrieved
881:
850:
807:
779:. Retrieved
774:
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753:. Retrieved
748:
739:
727:. Retrieved
720:
711:
697:
685:. Retrieved
680:
671:
659:. Retrieved
654:
645:
633:. Retrieved
628:
619:
607:. Retrieved
602:
593:
581:. Retrieved
572:
563:
508:
475:
463:
450:
438:blood plasma
415:
399:hemophilia A
390:
389:
368:Legal status
362:Legal status
325:octocog alfa
301:Legal status
295:Legal status
169:Legal status
163:Legal status
94:License data
70:octocog alfa
29:
1656:Ulinastatin
1601:amino acids
1558:Fibrin glue
1549:Epinephrine
1502:Eltrombopag
1492:Romiplostim
1417:II/Thrombin
1330:Coagulation
1282:coagulation
909:"Chapter 5"
817:10665/44053
494:recombinant
482:hemophiliac
442:recombinant
430:anaphylaxis
403:factor VIII
391:Factor VIII
337:Trade names
270:Trade names
234:Identifiers
131:Intravenous
67:Other names
58:Trade names
34:Factor VIII
1695:Categories
1553:adrenalone
1475:Etamsylate
1470:Concizumab
1460:Batroxobin
1395:extrinsic:
1340:intrinsic:
1037:0443069816
555:References
446:antibodies
428:including
240:ChemSpider
202:Schedule D
1652:unsorted
1631:Aprotinin
1299:Vitamin K
1226:Drugs.com
1214:Drugs.com
1202:Drugs.com
1190:Drugs.com
892:8 January
583:8 January
505:Economics
490:hepatitis
434:pregnancy
124:Routes of
86:Monograph
80:Drugs.com
1685:Medicine
1646:Camostat
1573:Thrombin
1544:Collagen
1453:systemic
1291:Systemic
1168:30042145
1108:28895852
1058:(2019).
1042:Archived
1001:Archived
968:Archived
927:Archived
886:Archived
687:31 March
661:10 April
635:10 April
577:Archived
518:See also
395:bleeding
347:ATC code
280:ATC code
139:ATC code
113:Kovaltry
108:DailyMed
18:Kogenate
1625:serpins
1409:common:
1332:factors
1159:6058236
1116:3779939
781:20 June
755:20 June
729:7 April
609:9 April
472:History
274:Adynovi
198: /
194::
155:)
149: (
147:B02BD02
110::
1671:Portal
1166:
1156:
1114:
1106:
1034:
993:
960:
919:
857:
824:
478:plasma
420:, and
341:Advate
213:℞-only
211:
200:
196:℞-only
182:
106:
1527:Local
1451:Other
1112:S2CID
418:fever
1427:XIII
1345:VIII
1164:PMID
1104:PMID
1032:ISBN
991:ISBN
958:ISBN
917:ISBN
894:2017
855:ISBN
822:ISBN
783:2024
757:2024
731:2024
689:2024
663:2023
637:2023
611:2023
585:2017
488:and
440:. A
354:None
287:None
247:none
133:(IV)
76:AHFS
1398:VII
1268:B02
1154:PMC
1146:doi
1096:doi
1064:hdl
1024:doi
950:doi
812:hdl
486:HIV
152:WHO
1697::
1385:,
1381:/(
1379:IX
1371:,
1367:,
1363:,
1359:,
1355:,
1351:,
1347:/(
1224:.
1212:.
1200:.
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1124:^
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1102:.
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1090:.
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999:.
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627:.
601:.
575:.
571:.
468:.
456:.
424:.
413:.
377:EU
310:EU
219:EU
207:US
191:CA
184:S4
178:AU
103:US
1673::
1551:/
1429:/
1412:X
1400:/
1389:)
1375:)
1320:)
1318:3
1311:)
1309:1
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1280:(
1270:)
1266:(
1256:e
1249:t
1242:v
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1170:.
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