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423:). It was the first ligand found to act as an agonist selective for this group of mGlu receptors, but does not show selectivity between the different mGluR Group III subtypes. It is widely used in the study of this receptor family and their various functions.
607:
Maciejak P, Szyndler J, Turzyńska D, Sobolewska A, Taracha E, Skórzewska A, et al. (July 2009). "The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration".
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Macinnes N, Duty S (February 2008). "Group III metabotropic glutamate receptors act as hetero-receptors modulating evoked GABA release in the globus pallidus in vivo".
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560:"Effects of activation of group III metabotropic glutamate receptors on spinal synaptic transmission in a rat model of neuropathic pain"
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InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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Lopez S, Turle-Lorenzo N, Acher F, De
Leonibus E, Mele A, Amalric M (June 2007).
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1681:Glutamate metabolism/transport modulators
1588:Tooltip Metabotropic glutamate receptor 8
1489:Tooltip Metabotropic glutamate receptor 7
1417:Tooltip Metabotropic glutamate receptor 6
1313:Tooltip Metabotropic glutamate receptor 4
1164:Tooltip Metabotropic glutamate receptor 3
1006:Tooltip Metabotropic glutamate receptor 2
820:Tooltip Metabotropic glutamate receptor 5
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1220:Pomaglumetad methionil (LY-2140023)
1072:Pomaglumetad methionil (LY-2140023)
105:
1715:. You can help Knowledge (XXG) by
576:10.1016/j.neuroscience.2008.10.042
268:
72:)-2-Amino-4-phosphonobutanoic acid
14:
1695:
525:European Journal of Pharmacology
390:metabotropic glutamate receptors
382:-2-amino-4-phosphonobutyric acid
259:
253:
47:-2-Amino-4-phosphonobutyric acid
27:
1616:Positive allosteric modulators:
1567:Negative allosteric modulators:
1356:Positive allosteric modulators:
1274:Negative allosteric modulators:
1138:Negative allosteric modulators:
1081:Positive allosteric modulators:
937:Negative allosteric modulators:
880:Positive allosteric modulators:
678:Metabotropic glutamate receptor
346:Key:DDOQBQRIEWHWBT-VKHMYHEASA-N
622:10.1016/j.brainres.2009.05.049
492:10.1523/JNEUROSCI.0299-07.2007
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1673:Receptor/signaling modulators
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480:The Journal of Neuroscience
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237:Chemical and physical data
1792:Nervous system drug stubs
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1205:LY-404,039 (pomaglumetad)
1052:LY-404,039 (pomaglumetad)
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1707:article relating to the
1084:JNJ-40411813 (ADX-71149)
1787:MGlu8 receptor agonists
1782:MGlu7 receptor agonists
1777:MGlu6 receptor agonists
1772:MGlu4 receptor agonists
321:C(CP(=O)(O)O)(C(=O)O)N
441:General Pharmacology
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388:for the group III
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1717:expanding it
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1626:Antagonists:
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1443:Antagonists:
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1371:Antagonists:
1370:
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1232:Antagonists:
1231:
1225:Talaglumetad
1171:
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1091:Antagonists:
1090:
1080:
1077:Talaglumetad
1013:
950:Dipraglurant
945:Basimglurant
936:
890:Antagonists:
889:
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769:Antagonists:
768:
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564:Neuroscience
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447:(2): 151–8.
444:
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69:
1352:VU-0155,041
1277:Decoglurant
1141:Decoglurant
975:Raseglurant
923:Remeglurant
908:Mavoglurant
772:BAY 36-7620
283: g·mol
226:100.164.384
52:Identifiers
41:Other names
1756:Categories
1619:AZ12216052
1359:Foliglurax
1347:VU-001,171
1260:LY-341,495
1255:LY-307,452
1210:LY-487,379
1200:LY-379,268
1119:LY-341,495
1114:LY-307,452
1062:LY-566,332
1057:LY-487,379
1047:LY-379,268
903:LY-344,545
883:LSN2463359
792:LY-456,236
787:LY-367,385
681:modulators
427:References
288:3D model (
276:Molar mass
176:C8M58SS68H
147:ChemSpider
127:IUPHAR/BPS
91:23052-81-5
82:CAS Number
61:IUPAC name
1670:See also:
1604:Glutamate
1596:Agonists:
1518:LSP2-9166
1505:Glutamate
1497:Agonists:
1428:Glutamate
1425:Agonists:
1337:LSP2-9166
1324:Glutamate
1321:Agonists:
1296:Group III
1282:RO4491533
1190:Glutamate
1185:Eglumegad
1172:Agonists:
1146:RO4491533
1037:Glutamate
1032:Eglumegad
1014:Agonists:
861:Glutamate
836:ADX-47273
828:Agonists:
752:Ro67-7476
747:Ro67-4853
742:Ro01-6128
727:Glutamate
714:Agonists:
1654:UBP-1112
1570:ADX71743
1558:UBP-1112
1471:UBP-1112
1399:UBP-1112
1270:MGS-0039
1215:MGS-0028
1129:MGS-0039
1067:MGS-0028
989:Group II
933:SIB-1893
928:SIB-1757
918:NPS-2390
802:NPS-2390
762:Theanine
638:20844494
630:19481536
616:: 20–7.
594:19017536
545:18035348
510:17581957
365:(verify)
960:GRN-529
955:Fenobam
940:AZD9272
876:VU-1545
777:CPCCOEt
689:Group I
585:2649787
501:6672706
461:9251893
386:agonist
281:183.100
243:Formula
102:PubChem
1563:XAP044
1500:AMN082
1180:DCG-IV
1175:CBiPES
1134:PCCG-4
1027:DCG-IV
1022:CBiPES
636:
628:
592:
582:
543:
508:
498:
459:
314:SMILES
156:156157
116:179394
1711:is a
1703:This
1581:mGluR
1538:MMPIP
1482:mGluR
1410:mGluR
1342:PHCCC
1306:mGluR
1250:HYDIA
1240:CECXG
1235:APICA
1157:mGluR
1109:HYDIA
1099:CECXG
1094:APICA
999:mGluR
898:DMeOB
841:CDPPB
813:mGluR
757:VU-71
699:mGluR
634:S2CID
394:mGluR
375:L-AP4
334:InChI
290:JSmol
21:L-AP4
1713:stub
1705:drug
1649:MTPG
1644:MSOP
1639:MPPG
1634:MAP4
1629:CPPG
1612:-AP4
1599:DCPG
1553:MTPG
1548:MSOP
1543:MPPG
1533:MAP4
1528:CPPG
1513:-AP4
1466:MTPG
1461:MSOP
1456:MPPG
1451:MAP4
1446:CPPG
1436:-AP4
1394:MTPG
1389:MSOP
1384:MPPG
1379:MAP4
1374:CPPG
1364:MPEP
1332:-AP4
1265:MCPG
1245:EGLU
1124:MCPG
1104:EGLU
1017:BINA
970:MTEP
965:MPEP
913:MCPG
893:CTEP
856:DHPG
846:CHPG
831:ACPD
797:MCPG
722:DHPG
717:ACPD
626:PMID
614:1282
590:PMID
541:PMID
506:PMID
457:PMID
167:UNII
136:1410
851:DFB
618:doi
580:PMC
572:doi
568:158
533:doi
529:580
496:PMC
488:doi
449:doi
192:EPA
106:CID
1758::
1679:•
1675:•
1614:;
1565:;
1354:;
1272:;
1136:;
1079:;
935:;
878:;
632:.
624:.
612:.
588:.
578:.
566:.
562:.
539:.
527:.
504:.
494:.
484:27
482:.
478:.
455:.
445:29
443:.
257:10
68:(2
1744:e
1737:t
1730:v
1719:.
1610:L
1583:8
1511:L
1484:7
1434:L
1412:6
1330:L
1308:4
1159:3
1001:2
815:5
701:1
670:e
663:t
656:v
640:.
620::
596:.
574::
547:.
535::
512:.
490::
463:.
451::
420:8
416:/
412:7
408:/
404:6
400:/
396:4
392:(
380:L
377:(
292:)
269:P
266:5
263:O
260:N
254:H
251:4
248:C
194:)
190:(
70:S
45:L
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