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Luis Federico Leloir

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796: 740:, a friend and colleague of Leloir, claims that his lasting legacy was proving that "scientific research on an international level, although precarious, was possible in an underdeveloped country in the middle of political strife" and credits Leloir's vigilance and will for his ultimate success. With his research in dire financial straits, Leloir often resorted to homemade gadgets and contraptions to continue his work in the laboratory. In one instance, Leloir reportedly used waterproof cardboard to create makeshift gutters in order to protect his laboratory's library from the rain. 49: 784: 112: 365:(golf sauce). After being served prawns with the usual sauce during lunch with a group of friends at the Ocean Club in Mar del Plata, Leloir came up with a peculiar combination of ketchup and mayonnaise to spice up his meal. With the financial difficulties that later plagued Leloir's laboratories and research, he would joke, "If I had patented that sauce, we'd have a lot more money for research right now." 657: 776: 2185: 533: 552:. Initially, the institute was composed of five rooms, a bathroom, central hall, patio, kitchen, and changing room. During the final years of the 1940s, although lacking financial resources and operating with very low-cost teams, Leloir's successful experiments would reveal the chemical origins of sugar synthesis in 704:
and remarked, "never have I received so much for so little". Leloir and his team reportedly celebrated by drinking champagne from test tubes, a rare departure from the humility and frugality that characterized the atmosphere of FundaciĂłn Instituto Campomar under Leloir's direction. The $ 80,000 prize
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Leloir's parents, Federico Augusto Rufino Leloir Bernal and Hortensia Aguirre de Leloir, traveled from Buenos Aires to Paris in the middle of 1906 with the intention of treating Federico's illness. However, Federico died in late August, and a week later Luis was born in an old house at 81 VĂ­ctor Hugo
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in the United States desperate for funding, and surprisingly was accepted. In 1958, the institute found a new home in a former all-girls school, a donation from the Argentine government. As Leloir and his research gained greater prominence, further research came from the Argentine Research Council,
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in the liver; together with J. M. Muñoz, he produced an active cell-free system, a first in scientific research. It had initially been assumed that in order to study a cell, scientists could not separate it from its host organism, as oxidation could only occur in intact cells. Along the way, Muñoz
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At the beginning of 1948, Leloir and his team identified the sugar nucleotides that were fundamental to the metabolism of carbohydrates, turning the Instituto Campomar into a biochemistry institution well known throughout the world. Immediately thereafter, Leloir received the Argentine Scientific
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and drop him off at 1719 Julián Alvarez Street, location of Fundación Instituto Campomar, with Leloir wearing the same worn out, gray overalls. He worked sitting on the same straw seat for decades and encouraged colleagues to eat lunch in the laboratory to save time, bringing enough meat stew to
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and his medical internship in Ramos MejĂ­a hospital. After some initial conflicts with colleagues and complications in his method of treating patients, Leloir decided to dedicate himself to research in the laboratory, claiming that "we could do little for our patients... antibiotics, psychoactive
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During his childhood, the future Nobel Prize winner found himself observing natural phenomena with particular interest; his schoolwork and readings highlighted the connections between the natural sciences and biology. His education was divided between Escuela General San MartĂ­n (primary school),
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at the University of Buenos Aires, which named Leloir, Carlos Eugenio Cardini and Enrico Cabib as titular professors in the university's newly founded Biochemical Institute. The institute would help develop scientific programs in budding Argentine universities as well as attract researchers and
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Leloir returned to Buenos Aires in 1937 after his brief stay at Cambridge. 1943 saw Leloir marry; Luis Leloir and Amelia Zuberbuhler (1920-2013) would later have a daughter also named Amelia. However, his return to Argentina was amidst conflict and strife; Houssay had been expelled from the
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As his work in the laboratory was coming to an end, Leloir continued his teaching position in the Department of Natural Sciences at the University of Buenos Aires, taking a hiatus only to complete his studies at Cambridge and at the Enzyme Research Laboratory in the United States.
710:"This is only one step in a much larger project. I discovered (no, not me: my team) the function of sugar nucleotides in cell metabolism. I want others to understand this, but it is not easy to explain: this is not a very noteworthy deed, and we hardly know even a little 422:. The two would develop a close relationship, collaborating on various projects until Houssay's death in 1971; in his lecture after winning the Nobel Prize, Leloir claimed that his "whole research career has been influenced by one person, Prof. Bernardo A. Houssay". 379: 755:, and has grown to become a 21,000 sq ft (2,000 m) building with 20 senior researchers, 42 technicians and administrative personnel, 8 post doctorate fellows, and 20 Ph.D. candidates. The institute conducts research in a variety of fields, including 1894: 430:
After only two years, Leloir received recognition from the medical department at the University of Buenos Aires for having produced the best doctoral thesis. Feeling that his knowledge in fields such as
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in hopes of receiving his doctorate. However, he got off to a rocky start, requiring four attempts to pass his anatomy exam. He finally received his diploma in 1932 and began his residency in the
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Cardini, C. E.; Paladini, A. C.; Caputto, R.; Leloir, L. F. (1950). "Uridine Diphosphate Glucose: The Coenzyme of the Galactose–Glucose Phosphate Isomerization".
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Leloir was known for his humility, focus and consistency, described by many as a "true monk in science". Every morning his wife Amelia would drive him in their
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With maternal name included (in usual Spanish-language practice) his name would be Luis Federico Leloir Aguirre, but the "Aguirre" is nearly always omitted.
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and Leloir, unable to procure the costly refrigerated centrifuge needed to separate cell contents, improvised by spinning a tire stuffed with salt and ice.
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share with everyone. Indeed, despite Leloir's frugality and extreme dedication to his research, he was a sociable man, claiming not to like working alone.
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Society Prize, one of the many awards he would receive both in Argentina and internationally. During this time, his team dedicated itself to the study of
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is lacking, he continued attending classes at the university as a part-time student. In 1936 he traveled to England to begin advanced studies at the
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as a research assistant. Leloir would later credit Green with instilling within him the initiative to establish his own research in Argentina.
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He died in Buenos Aires on December 2, 1987, of a heart attack soon after returning to his home from the laboratory, and is buried in
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are synthesized and converted into energy in the body. Although born in France, Leloir received the majority of his education at the
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garnered international attention and led to significant progress in understanding, diagnosing and treating the congenital disease
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and was director of the private research group FundaciĂłn Instituto Campomar until his death in 1987. His research into sugar
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Zorreguieta, Angeles; Ugalde, Rodolfo A.; Leloir, Luis F. (1985). "An intermediate in cyclic β1–2 glucan biosynthesis".
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Leloir, Luis F. (1951). "The enzymatic transformation of uridine diphosphate glucose into a galactose derivative".
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Parodi AJ, Krisman CR, Leloir LF, Mordoh J (September 1967). "Properties of synthetic and native liver glycogen".
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money was spent directly on research, and when asked about the significance of his achievement, Leloir responded:
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on succinic dehydrogenase; from this moment Leloir began to specialize in researching carbohydrate metabolism.
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Lorenzano, Julio CĂ©sar. Por los caminos de Leloir. Editorial Biblos; 1a edition, July 1994. ISBN 9-5078-6063-0
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In 1983, Leloir became one of the founding members of the Third World Academy of Sciences, later renamed the
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in maintaining good health. Leloir's research in the Biochemical Laboratory of Cambridge centered around
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NachĂłn, Carlos Alberto. Luis Federico Leloir: ensayo de una biografĂ­a. Bank Foundation of Boston, 1994.
613:; Leloir and his colleagues elucidated the primary mechanisms of galactose metabolism (now called the 3599: 3594: 3302: 3006: 2799: 2648: 2381: 1630: 1422: 800: 733: 726: 287: 1399:"The Substance Causing Renal Hypertension"(E. Braun-Menedez, J.C. Fasciolo, L.F. Leloir, J.M. Muñoz) 1163: 653:
In his later years Leloir continued to study glycogen and other aspects of carbohydrate metabolism.
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Zuberbuhler de Leloir, Amelia. Retrato personal de Leloir. Vol. 8, No. 25, pp. 45–46, 1983.
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In 1945, Leloir ended his exile and returned to Argentina to work under Houssay at the
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Leloir published a short autobiography, entitled "Long Ago and Far Away" in the 1983
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and the institute would later become associated with the University of Buenos Aires.
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Ariel Barrios Medina, "Luis Federico Leloir (1906-1987): un esbozo biográfico" web:
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http://www.oni.escuelas.edu.ar/olimpi98/ConociendoNuestraCiencia/nobel%20leloir.html
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On December 2, 1970, Leloir received the Nobel Prize for Chemistry from the King of
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Leloir celebrating with colleagues December 10, 1970, after winning the Nobel Prize.
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http://nobelprize.org/nobel_prizes/chemistry/laureates/1970/leloir-lecture.html
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Trucco, R.E.; Caputto, R; Leloir, L.F.; Mittelman, N (1948). "Galactokinase".
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Luis Leloir, "Two decades of research on the biosynthesis of saccharides" web:
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Caputto, R; Leloir, L.F.; Trucco, R.E.; Cardini, C.E.; Paladini, A C (1949).
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Following Jaime Campomar's death in 1957, Leloir and his team applied to the
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The following year, he reached an agreement with Rolando GarcĂ­a, dean of the
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Leloir (left) with Armando Parodi and his daughter Amelia in the laboratory.
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http://www.clubdelprogreso.com/index.php?sec=04_05&sid=43&id=2513
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Elected an International Member of the U.S. National Academy of Sciences
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Valeria Roman, "A cien años del nacimiento de Luis Federico Leloir" web:
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University of Buenos Aires for signing a public petition opposing the
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that his grandparents had purchased after their immigration from the
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Kresge, Nicole; Simoni, Robert D; Hill, Robert L. (May 13, 2005).
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Instituto de Investigaciones BioquĂ­micas de la FundaciĂłn Campomar
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and carbohydrate metabolism. Houssay happened to be friends with
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http://www.clarin.com/diario/2006/08/27/sociedad/s-01259864.htm
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Argentina Chemistry Association's Juan José Jolly Kyle Award
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drugs, and all the new therapeutic agents were unknown ."
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Leloir (top left) with family on an Argentine resort, 1951
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Holton JB, Walter JH, and Tyfield LA. "Galactosemia" in
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Honorary Doctorate from Universidad Nacional de CĂłrdoba
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The FundaciĂłn Instituto Campomar has since been renamed
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Foreign associates of the National Academy of Sciences
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The Metabolic and Molecular Bases of Inherited Disease
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Foreign Member of the Royal Society (ForMemRS) in 1972
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Luis Leloir and Carlos Eugenio Cardini at work in the
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which has since become a popular tourist attraction.
1369:"Luis F. Leloir and the Biosynthesis of Saccharides" 1034:
Biographical Memoirs of Fellows of the Royal Society
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Biochemical and Biophysical Research Communications
921:Honorary member of the English Biochemical Society 725:. The title, Leloir claims, is derived from one of 202: 192: 150: 132: 122: 105: 83: 58: 39: 1336: 1334: 1332: 1617:Mordoh J, Leloir LF, Krisman CR (January 1965). 1211:. Sociedad Argentina de Diabetes. Archived from 787:Leloir with his wife Amelia and cardiac surgeon 1926:The Official Site of Louisa Gross Horwitz Prize 707: 27:Argentine physician and biochemist (1906–1987) 3670:Members of the American Philosophical Society 3346: 1946: 1607:, Thomas Gale, Thomson Corporation, 2005-2006 1600: 1598: 359:It was during the 1920s that Leloir invented 53:An early photograph of Leloir in his twenties 30:"Leloir" redirects here. For other uses, see 8: 1619:"In vitro Synthesis of Particulate Glycogen" 1235: 1233: 1231: 1229: 568:By 1947 he had formed a team that included 349: 340:(secondary school), and for a few months at 1285:Green, D E; Leloir, L F; Nocito, V (1945). 520:at the College of Physicians and Surgeons, 3645:Washington University in St. Louis faculty 3353: 3339: 3331: 1953: 1939: 1931: 308:Road in Paris, a few blocks away from the 36: 1742: 1697: 1652: 1642: 1565: 1520: 1510: 1442: 1384: 1312: 1302: 1139: 1129: 1045: 602:Galactose-1-phosphate uridylyltransferase 939:Legion de Honor “Orden de AndrĂ©s Bello” 806: 531: 220:FundaciĂłn Instituto Campomar (1947–1981) 1875:American Academy of Arts & Sciences 1546:Archives of Biochemistry and Biophysics 1015: 856:Elected an International Member of the 1107: 1105: 1103: 1101: 1099: 459:and in revealing the critical role of 420:Nobel Prize for Physiology or Medicine 1023: 1021: 1019: 847:American Academy of Arts and Sciences 630:Faculty of Exact and Natural Sciences 7: 3635:Foreign members of the Royal Society 3625:Illustrious Citizens of Buenos Aires 492:and the military government led by 1767:"The Nobel Prize in Chemistry 1970" 1373:The Journal of Biological Chemistry 1131:10.1146/annurev.bi.52.070183.000245 467:, more specifically the effects of 1815:Mario Bunge, "Luis F. Leloir" web: 1794:. Chubut Argentina. Archived from 506:Washington University in St. Louis 211:Washington University in St. Louis 25: 3675:20th-century Argentine physicians 3665:20th-century Argentine biologists 3650:University of Buenos Aires alumni 633:scholars from the United States, 2183: 867:Bunge and Born Foundation Award 110: 47: 3655:Burials at La Recoleta Cemetery 1272:"Bernardo Houssay Biographical" 829:T. Ducett Jones Memorial Award 858:American Philosophical Society 1: 1605:World of Scientific Discovery 1512:10.1016/S0021-9258(18)56863-0 1386:10.1016/S0021-9258(20)67598-6 1304:10.1016/S0021-9258(17)41491-8 1118:Annual Review of Biochemistry 821:Third National Science Award 723:Annual Review of Biochemistry 700:'s famous 1940 speech to the 642:National Institutes of Health 3630:Nobel laureates in Chemistry 3605:Physicians from Buenos Aires 1735:10.1016/0006-291X(85)90613-8 1690:10.1016/0003-9861(67)90066-5 1623:Proc. Natl. Acad. Sci. U.S.A 1558:10.1016/0003-9861(51)90096-3 538:FundaciĂłn Instituto Campomar 528:FundaciĂłn Instituto Campomar 3620:Columbia University faculty 960:Order of Bernardo O'Higgins 799:Leloir family mausoleum in 516:and thereafter worked with 3691: 1921:FundaciĂłn Instituto Leloir 1082:"Biography of Luis Leloir" 888:Louisa Gross Horwitz Prize 875:Gairdner Foundation Award 753:FundaciĂłn Instituto Leloir 392:University of Buenos Aires 265:University of Buenos Aires 207:University of Buenos Aires 158:Louisa Gross Horwitz Prize 127:University of Buenos Aires 29: 3615:Argentine Nobel laureates 3512: 2181: 1401:The Journal of Physiology 988:: Science and Technology 684:for his discovery of the 453:Frederick Gowland Hopkins 386:After returning again to 350: 255:for his discovery of the 229: 185: 46: 3107:Venkatraman Ramakrishnan 2386:Wendell Meredith Stanley 1966:Nobel Prize in Chemistry 1124:. Annual Reviews: 1–15. 930:Nobel Prize in Chemistry 414:, the brother-in-law of 253:Nobel Prize in Chemistry 164:Nobel Prize in Chemistry 1403:(1940) no.98 pg.283-298 1114:"Far Away and Long Ago" 771:Awards and distinctions 449:University of Cambridge 412:Carlos Bonorino Udaondo 223:University of Cambridge 145:Carbohydrate metabolism 3518:Nobel Prize recipients 3464:Physiology or Medicine 3404:Aleksandr Solzhenitsyn 3271:Emmanuelle Charpentier 3259:M. Stanley Whittingham 2230:Hans von Euler-Chelpin 1871:"Luis Federico Leloir" 1792:"Luis Federico Leloir" 1678:Arch. Biochem. Biophys 1209:"Luis Federico Leloir" 1047:10.1098/rsbm.1990.0009 804: 792: 780: 714: 661: 605: 596:Chemical structure of 541: 383: 286:. Leloir is buried in 251:who received the 1970 3610:Argentine biochemists 2641:Christian B. Anfinsen 2281:FrĂ©dĂ©ric Joliot-Curie 1207:Pedro Tesone (2006). 1112:Leloir, Luis (1983). 798: 786: 778: 659: 595: 535: 508:, collaborating with 496:. Leloir fled to the 381: 326:San Clemente del TuyĂş 3380:Luis Federico Leloir 3303:Karl Barry Sharpless 2800:Dudley R. Herschbach 2625:Luis Federico Leloir 1899:search.amphilsoc.org 1895:"APS Member History" 1790:Comodoro Rivadavia. 1644:10.1073/pnas.53.1.86 897:Benito Juárez Award 801:La Recoleta Cemetery 734:La Recoleta Cemetery 727:William Henry Hudson 396:Hospital de ClĂ­nicas 288:La Recoleta Cemetery 236:Luis Federico Leloir 41:Luis Federico Leloir 3295:Carolyn R. Bertozzi 3207:Jean-Pierre Sauvage 2944:Jens Christian Skou 2912:F. Sherwood Rowland 2824:Charles J. Pedersen 2788:Herbert A. Hauptman 2481:Vincent du Vigneaud 2098:Richard Willstätter 1982:Jacobus van 't Hoff 1635:1965PNAS...53...86M 1427:1950Natur.165..191C 958:Grand Cross of the 884:Columbia University 761:Parkinson's disease 757:Alzheimer's disease 696:, he borrowed from 623:lactose intolerance 522:Columbia University 494:Pedro Pablo RamĂ­rez 352:École Polytechnique 216:Columbia University 141:Lactose intolerance 3255:John B. Goodenough 3183:William E. Moerner 3063:Richard R. Schrock 3035:Roderick MacKinnon 3007:K. Barry Sharpless 2832:Johann Deisenhofer 2661:Geoffrey Wilkinson 2657:Ernst Otto Fischer 2581:Robert S. Mulliken 2517:Jaroslav HeyrovskĂ˝ 2465:Hermann Staudinger 2285:Irène Joliot-Curie 1833:2007-09-24 at the 1246:2007-06-17 at the 1194:2016-07-29 at the 1028:Ochoa, S. (1990). 805: 793: 781: 765:multiple sclerosis 686:metabolic pathways 662: 606: 542: 384: 338:Colegio Lacordaire 257:metabolic pathways 3582: 3581: 3495:Economic Sciences 3328: 3327: 3311:Moungi G. Bawendi 3231:Richard Henderson 3075:Roger D. Kornberg 3043:Aaron Ciechanover 2876:Rudolph A. Marcus 2780:Robert Merrifield 2716:Peter D. Mitchell 2489:Cyril Hinshelwood 2250:Friedrich Bergius 2174:Richard Zsigmondy 2090:Theodore Richards 2038:Ernest Rutherford 1851:www.nasonline.org 1421:(4188): 191–192. 992: 991: 698:Winston Churchill 621:that resulted in 588:Sugar nucleotides 408:suprarenal glands 233: 232: 187:Scientific career 69:September 6, 1906 16:(Redirected from 3682: 3520: 3355: 3348: 3341: 3332: 3321: 3319:Alexei I. Ekimov 3305: 3299:Morten P. Meldal 3289: 3277: 3265: 3249: 3233: 3223:Jacques Dubochet 3217: 3201: 3185: 3169: 3153: 3147:Robert Lefkowitz 3141: 3133: 3117: 3111:Thomas A. Steitz 3101: 3085: 3077: 3069: 3059:Robert H. Grubbs 3053: 3037: 3025: 3009: 2982: 2980:Hideki Shirakawa 2966: 2958: 2946: 2930: 2914: 2898: 2890: 2878: 2870: 2868:Richard R. Ernst 2862: 2854: 2842: 2826: 2810: 2794: 2782: 2774: 2766: 2758: 2746: 2744:Frederick Sanger 2730: 2724:Herbert C. Brown 2718: 2710: 2702: 2700:William Lipscomb 2683: 2671: 2663: 2651: 2635: 2633:Gerhard Herzberg 2627: 2619: 2607: 2599: 2583: 2575: 2567: 2559: 2547: 2535: 2527: 2519: 2511: 2509:Frederick Sanger 2503: 2495: 2493:Nikolay Semyonov 2483: 2475: 2467: 2459: 2447: 2445:Glenn T. Seaborg 2424: 2412: 2404: 2396: 2388: 2372: 2370:Artturi Virtanen 2364: 2356: 2354:George de Hevesy 2348: 2347: 2341: 2340: 2334: 2333: 2327: 2315: 2307: 2295: 2287: 2275: 2267: 2266: 2260: 2252: 2240: 2232: 2220: 2212: 2210:Heinrich Wieland 2204: 2202:Theodor Svedberg 2187: 2186: 2176: 2168: 2167: 2161: 2153: 2145: 2137: 2129: 2128: 2122: 2114: 2113: 2107: 2106: 2100: 2092: 2084: 2076: 2064: 2056: 2048: 2040: 2032: 2024: 2016: 2014:Adolf von Baeyer 2008: 2000: 1998:Svante Arrhenius 1992: 1984: 1955: 1948: 1941: 1932: 1909: 1908: 1906: 1905: 1891: 1885: 1884: 1882: 1881: 1867: 1861: 1860: 1858: 1857: 1847:"Luis F. Leloir" 1843: 1837: 1828:Leloir Institute 1825: 1819: 1813: 1807: 1806: 1804: 1803: 1787: 1781: 1780: 1778: 1777: 1763: 1757: 1756: 1746: 1718: 1712: 1711: 1701: 1673: 1667: 1666: 1656: 1646: 1614: 1608: 1602: 1593: 1586: 1580: 1579: 1569: 1541: 1535: 1534: 1524: 1514: 1490: 1484: 1483: 1463: 1457: 1456: 1446: 1435:10.1038/165191a0 1410: 1404: 1397: 1391: 1390: 1388: 1364: 1358: 1357: 1355: 1354: 1345:. Archived from 1338: 1327: 1326: 1316: 1306: 1282: 1276: 1275: 1268: 1262: 1256: 1250: 1237: 1224: 1223: 1221: 1220: 1204: 1198: 1185: 1179: 1178: 1176: 1175: 1168:WelcomeArgentina 1160: 1154: 1153: 1143: 1133: 1109: 1094: 1093: 1091: 1089: 1084:. Nobelprize.org 1078: 1069: 1066: 1060: 1059: 1049: 1025: 975:Legion of Honour 807: 702:House of Commons 619:genetic disorder 404:Bernardo Houssay 402:In 1933, he met 355: 354: 342:Beaumont College 275:metabolism, and 242: 176:Legion of Honour 115: 114: 90: 87:December 2, 1987 68: 66: 51: 37: 21: 3690: 3689: 3685: 3684: 3683: 3681: 3680: 3679: 3585: 3584: 3583: 3578: 3516: 3508: 3505:(United States) 3489: 3486:(Great Britain) 3474:(United States) 3458: 3433: 3430:(United States) 3409: 3385: 3366: 3359: 3329: 3324: 3308: 3292: 3283:David MacMillan 3280: 3275:Jennifer Doudna 3268: 3252: 3236: 3220: 3211:Fraser Stoddart 3204: 3195:Paul L. Modrich 3188: 3172: 3156: 3144: 3136: 3131:Ei-ichi Negishi 3123:Richard F. Heck 3120: 3104: 3091:Osamu Shimomura 3088: 3080: 3072: 3056: 3040: 3028: 3012: 2999:William Knowles 2996: 2985: 2976:Alan MacDiarmid 2969: 2961: 2949: 2933: 2928:Richard Smalley 2917: 2904:Paul J. Crutzen 2901: 2893: 2881: 2873: 2865: 2857: 2845: 2829: 2820:Jean-Marie Lehn 2813: 2797: 2785: 2777: 2769: 2761: 2749: 2733: 2721: 2713: 2705: 2697: 2686: 2681:Vladimir Prelog 2674: 2666: 2654: 2638: 2630: 2622: 2610: 2602: 2586: 2578: 2573:Robert Woodward 2570: 2565:Dorothy Hodgkin 2562: 2550: 2538: 2530: 2522: 2514: 2506: 2498: 2486: 2478: 2470: 2462: 2450: 2438: 2427: 2415: 2410:William Giauque 2407: 2399: 2394:Robert Robinson 2391: 2378:James B. Sumner 2375: 2367: 2359: 2351: 2345: 2344: 2338: 2337: 2331: 2330: 2325:Leopold RuĹľiÄŤka 2321:Adolf Butenandt 2318: 2310: 2298: 2290: 2278: 2270: 2264: 2263: 2258:Irving Langmuir 2255: 2243: 2235: 2223: 2215: 2207: 2199: 2188: 2184: 2179: 2171: 2165: 2164: 2156: 2148: 2143:Frederick Soddy 2140: 2132: 2126: 2125: 2117: 2111: 2110: 2104: 2103: 2095: 2087: 2079: 2070:Victor Grignard 2067: 2059: 2051: 2046:Wilhelm Ostwald 2043: 2035: 2027: 2019: 2011: 2003: 1995: 1987: 1979: 1968: 1959: 1917: 1912: 1903: 1901: 1893: 1892: 1888: 1879: 1877: 1869: 1868: 1864: 1855: 1853: 1845: 1844: 1840: 1835:Wayback Machine 1826: 1822: 1814: 1810: 1801: 1799: 1789: 1788: 1784: 1775: 1773: 1765: 1764: 1760: 1720: 1719: 1715: 1675: 1674: 1670: 1616: 1615: 1611: 1603: 1596: 1587: 1583: 1543: 1542: 1538: 1492: 1491: 1487: 1465: 1464: 1460: 1412: 1411: 1407: 1398: 1394: 1366: 1365: 1361: 1352: 1350: 1341: 1339: 1330: 1287:"Transaminases" 1284: 1283: 1279: 1270: 1269: 1265: 1257: 1253: 1248:Wayback Machine 1238: 1227: 1218: 1216: 1206: 1205: 1201: 1196:Wayback Machine 1186: 1182: 1173: 1171: 1162: 1161: 1157: 1111: 1110: 1097: 1087: 1085: 1080: 1079: 1072: 1067: 1063: 1027: 1026: 1017: 1013: 997: 845:Elected to the 773: 719: 678: 651: 590: 556:as well as the 530: 481: 428: 416:Victoria Ocampo 376: 371: 310:Arc de Triomphe 305: 300: 238: 221: 219: 214: 209: 181: 143: 139: 123:Alma mater 109: 101: 92: 88: 79: 70: 64: 62: 54: 42: 35: 28: 23: 22: 15: 12: 11: 5: 3688: 3686: 3678: 3677: 3672: 3667: 3662: 3657: 3652: 3647: 3642: 3637: 3632: 3627: 3622: 3617: 3612: 3607: 3602: 3597: 3587: 3586: 3580: 3579: 3577: 3576: 3571: 3566: 3561: 3556: 3551: 3546: 3541: 3536: 3531: 3526: 3521: 3513: 3510: 3509: 3507: 3506: 3503:Paul Samuelson 3499: 3497: 3491: 3490: 3488: 3487: 3481: 3475: 3472:Julius Axelrod 3468: 3466: 3460: 3459: 3457: 3456: 3450: 3443: 3441: 3435: 3434: 3432: 3431: 3428:Norman Borlaug 3424: 3422: 3411: 3410: 3408: 3407: 3406:(Soviet Union) 3400: 3398: 3387: 3386: 3384: 3383: 3376: 3374: 3368: 3367: 3360: 3358: 3357: 3350: 3343: 3335: 3326: 3325: 3323: 3322: 3306: 3290: 3278: 3266: 3250: 3243:Gregory Winter 3239:Frances Arnold 3234: 3218: 3202: 3186: 3170: 3163:Michael Levitt 3159:Martin Karplus 3154: 3142: 3134: 3118: 3102: 3099:Roger Y. Tsien 3095:Martin Chalfie 3086: 3078: 3070: 3054: 3038: 3026: 3010: 2993: 2991: 2987: 2986: 2984: 2983: 2972:Alan J. Heeger 2967: 2959: 2947: 2940:John E. Walker 2931: 2915: 2899: 2891: 2879: 2871: 2863: 2855: 2843: 2840:Hartmut Michel 2827: 2816:Donald J. Cram 2811: 2795: 2783: 2775: 2767: 2759: 2756:Roald Hoffmann 2747: 2740:Walter Gilbert 2731: 2719: 2711: 2708:Ilya Prigogine 2703: 2694: 2692: 2688: 2687: 2685: 2684: 2677:John Cornforth 2672: 2664: 2652: 2645:Stanford Moore 2636: 2628: 2620: 2608: 2600: 2593:Ronald Norrish 2584: 2576: 2568: 2560: 2548: 2536: 2528: 2520: 2512: 2504: 2501:Alexander Todd 2496: 2484: 2476: 2468: 2460: 2448: 2441:Edwin McMillan 2435: 2433: 2429: 2428: 2426: 2425: 2413: 2405: 2397: 2389: 2373: 2365: 2357: 2349: 2342: 2335: 2328: 2316: 2308: 2301:Norman Haworth 2296: 2288: 2276: 2268: 2261: 2253: 2241: 2233: 2221: 2213: 2205: 2196: 2194: 2190: 2189: 2182: 2180: 2178: 2177: 2169: 2162: 2154: 2146: 2138: 2135:Walther Nernst 2130: 2123: 2115: 2108: 2101: 2093: 2085: 2077: 2065: 2057: 2049: 2041: 2033: 2030:Eduard Buchner 2025: 2017: 2009: 2006:William Ramsay 2001: 1993: 1985: 1976: 1974: 1970: 1969: 1960: 1958: 1957: 1950: 1943: 1935: 1929: 1928: 1923: 1916: 1915:External links 1913: 1911: 1910: 1886: 1862: 1838: 1820: 1808: 1782: 1771:NobelPrize.org 1758: 1729:(1): 352–357. 1713: 1668: 1609: 1594: 1581: 1552:(2): 186–190. 1536: 1505:(1): 497–498. 1485: 1474:(1): 137–146. 1458: 1405: 1392: 1359: 1328: 1297:(2): 559–582. 1277: 1263: 1251: 1225: 1199: 1180: 1155: 1095: 1070: 1061: 1014: 1012: 1009: 1008: 1007: 1004: 1001: 996: 993: 990: 989: 982: 978: 977: 972: 968: 967: 956: 952: 951: 945: 941: 940: 937: 933: 932: 927: 923: 922: 919: 915: 914: 911: 907: 906: 903: 899: 898: 895: 891: 890: 881: 877: 876: 873: 869: 868: 865: 861: 860: 854: 850: 849: 843: 839: 838: 835: 831: 830: 827: 823: 822: 819: 815: 814: 811: 772: 769: 718: 715: 677: 674: 650: 647: 615:Leloir pathway 589: 586: 570:Ranwel Caputto 550:Jaime Campomar 529: 526: 518:David E. Green 480: 477: 427: 424: 375: 372: 370: 367: 318:Basque Country 304: 301: 299: 296: 231: 230: 227: 226: 204: 200: 199: 194: 190: 189: 183: 182: 180: 179: 173: 167: 161: 154: 152: 148: 147: 134: 133:Known for 130: 129: 124: 120: 119: 107: 103: 102: 93: 91:(aged 81) 85: 81: 80: 71: 60: 56: 55: 52: 44: 43: 40: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 3687: 3676: 3673: 3671: 3668: 3666: 3663: 3661: 3658: 3656: 3653: 3651: 3648: 3646: 3643: 3641: 3638: 3636: 3633: 3631: 3628: 3626: 3623: 3621: 3618: 3616: 3613: 3611: 3608: 3606: 3603: 3601: 3598: 3596: 3593: 3592: 3590: 3575: 3572: 3570: 3567: 3565: 3562: 3560: 3557: 3555: 3552: 3550: 3547: 3545: 3542: 3540: 3537: 3535: 3532: 3530: 3527: 3525: 3522: 3519: 3515: 3514: 3511: 3504: 3501: 3500: 3498: 3496: 3492: 3485: 3482: 3479: 3478:Ulf von Euler 3476: 3473: 3470: 3469: 3467: 3465: 3461: 3454: 3451: 3448: 3447:Hannes AlfvĂ©n 3445: 3444: 3442: 3440: 3436: 3429: 3426: 3425: 3423: 3420: 3416: 3412: 3405: 3402: 3401: 3399: 3396: 3392: 3388: 3381: 3378: 3377: 3375: 3373: 3369: 3364: 3356: 3351: 3349: 3344: 3342: 3337: 3336: 3333: 3320: 3316: 3315:Louis E. Brus 3312: 3307: 3304: 3300: 3296: 3291: 3288: 3287:Benjamin List 3284: 3279: 3276: 3272: 3267: 3264: 3263:Akira Yoshino 3260: 3256: 3251: 3248: 3244: 3240: 3235: 3232: 3228: 3227:Joachim Frank 3224: 3219: 3216: 3212: 3208: 3203: 3200: 3196: 3192: 3191:Tomas Lindahl 3187: 3184: 3180: 3176: 3171: 3168: 3167:Arieh Warshel 3164: 3160: 3155: 3152: 3151:Brian Kobilka 3148: 3143: 3140: 3139:Dan Shechtman 3135: 3132: 3128: 3124: 3119: 3116: 3115:Ada E. Yonath 3112: 3108: 3103: 3100: 3096: 3092: 3087: 3084: 3079: 3076: 3071: 3068: 3064: 3060: 3055: 3052: 3048: 3047:Avram Hershko 3044: 3039: 3036: 3032: 3027: 3024: 3023:Kurt WĂĽthrich 3020: 3019:Koichi Tanaka 3016: 3011: 3008: 3004: 3000: 2995: 2994: 2992: 2988: 2981: 2977: 2973: 2968: 2965: 2960: 2957: 2953: 2948: 2945: 2941: 2937: 2936:Paul D. Boyer 2932: 2929: 2925: 2921: 2916: 2913: 2909: 2905: 2900: 2897: 2892: 2889: 2888:Michael Smith 2885: 2880: 2877: 2872: 2869: 2864: 2861: 2856: 2853: 2849: 2848:Sidney Altman 2844: 2841: 2837: 2833: 2828: 2825: 2821: 2817: 2812: 2809: 2805: 2801: 2796: 2793: 2789: 2784: 2781: 2776: 2773: 2768: 2765: 2760: 2757: 2753: 2752:Kenichi Fukui 2748: 2745: 2741: 2737: 2732: 2729: 2725: 2720: 2717: 2712: 2709: 2704: 2701: 2696: 2695: 2693: 2689: 2682: 2678: 2673: 2670: 2665: 2662: 2658: 2653: 2650: 2649:William Stein 2646: 2642: 2637: 2634: 2629: 2626: 2621: 2618: 2614: 2609: 2606: 2601: 2598: 2597:George Porter 2594: 2590: 2589:Manfred Eigen 2585: 2582: 2577: 2574: 2569: 2566: 2561: 2558: 2554: 2549: 2546: 2542: 2537: 2534: 2533:Melvin Calvin 2529: 2526: 2525:Willard Libby 2521: 2518: 2513: 2510: 2505: 2502: 2497: 2494: 2490: 2485: 2482: 2477: 2474: 2473:Linus Pauling 2469: 2466: 2461: 2458: 2457:Richard Synge 2454: 2453:Archer Martin 2449: 2446: 2442: 2437: 2436: 2434: 2430: 2423: 2419: 2414: 2411: 2406: 2403: 2402:Arne Tiselius 2398: 2395: 2390: 2387: 2383: 2382:John Northrop 2379: 2374: 2371: 2366: 2363: 2358: 2355: 2350: 2343: 2336: 2329: 2326: 2322: 2317: 2314: 2309: 2306: 2302: 2297: 2294: 2289: 2286: 2282: 2277: 2274: 2269: 2262: 2259: 2254: 2251: 2247: 2242: 2239: 2234: 2231: 2227: 2226:Arthur Harden 2222: 2219: 2218:Adolf Windaus 2214: 2211: 2206: 2203: 2198: 2197: 2195: 2191: 2175: 2170: 2163: 2160: 2155: 2152: 2151:Francis Aston 2147: 2144: 2139: 2136: 2131: 2124: 2121: 2116: 2109: 2102: 2099: 2094: 2091: 2086: 2083: 2082:Alfred Werner 2078: 2075: 2074:Paul Sabatier 2071: 2066: 2063: 2058: 2055: 2050: 2047: 2042: 2039: 2034: 2031: 2026: 2023: 2022:Henri Moissan 2018: 2015: 2010: 2007: 2002: 1999: 1994: 1991: 1986: 1983: 1978: 1977: 1975: 1971: 1967: 1963: 1956: 1951: 1949: 1944: 1942: 1937: 1936: 1933: 1927: 1924: 1922: 1919: 1918: 1914: 1900: 1896: 1890: 1887: 1876: 1872: 1866: 1863: 1852: 1848: 1842: 1839: 1836: 1832: 1829: 1824: 1821: 1818: 1812: 1809: 1798:on 2007-02-28 1797: 1793: 1786: 1783: 1772: 1768: 1762: 1759: 1754: 1750: 1745: 1740: 1736: 1732: 1728: 1724: 1717: 1714: 1709: 1705: 1700: 1695: 1691: 1687: 1684:(3): 769–78. 1683: 1679: 1672: 1669: 1664: 1660: 1655: 1650: 1645: 1640: 1636: 1632: 1628: 1624: 1620: 1613: 1610: 1606: 1601: 1599: 1595: 1591: 1585: 1582: 1577: 1573: 1568: 1563: 1559: 1555: 1551: 1547: 1540: 1537: 1532: 1528: 1523: 1518: 1513: 1508: 1504: 1500: 1499:J. Biol. Chem 1496: 1489: 1486: 1481: 1477: 1473: 1469: 1468:Arch. Biochem 1462: 1459: 1454: 1450: 1445: 1440: 1436: 1432: 1428: 1424: 1420: 1416: 1409: 1406: 1402: 1396: 1393: 1387: 1382: 1378: 1374: 1370: 1363: 1360: 1349:on 2008-04-23 1348: 1344: 1337: 1335: 1333: 1329: 1324: 1320: 1315: 1310: 1305: 1300: 1296: 1292: 1291:J. Biol. Chem 1288: 1281: 1278: 1273: 1267: 1264: 1261: 1255: 1252: 1249: 1245: 1242: 1236: 1234: 1232: 1230: 1226: 1215:on 2007-02-10 1214: 1210: 1203: 1200: 1197: 1193: 1190: 1184: 1181: 1169: 1165: 1159: 1156: 1151: 1147: 1142: 1137: 1132: 1127: 1123: 1119: 1115: 1108: 1106: 1104: 1102: 1100: 1096: 1083: 1077: 1075: 1071: 1065: 1062: 1057: 1053: 1048: 1043: 1039: 1035: 1031: 1024: 1022: 1020: 1016: 1010: 1005: 1002: 999: 998: 994: 987: 983: 980: 979: 976: 973: 970: 969: 965: 961: 957: 954: 953: 950: 946: 943: 942: 938: 935: 934: 931: 928: 925: 924: 920: 917: 916: 912: 909: 908: 904: 901: 900: 896: 893: 892: 889: 885: 882: 879: 878: 874: 871: 870: 866: 863: 862: 859: 855: 852: 851: 848: 844: 841: 840: 836: 833: 832: 828: 825: 824: 820: 817: 816: 812: 809: 808: 802: 797: 790: 789:RenĂ© Favaloro 785: 777: 770: 768: 766: 762: 758: 754: 749: 746: 741: 739: 735: 730: 728: 724: 716: 713: 711: 706: 703: 699: 695: 691: 687: 683: 675: 673: 671: 666: 658: 654: 648: 646: 643: 638: 636: 631: 626: 624: 620: 616: 612: 611:glycoproteins 603: 599: 594: 587: 585: 583: 582:mammary gland 579: 576:helped cause 575: 571: 566: 563: 559: 555: 551: 547: 539: 534: 527: 525: 523: 519: 515: 511: 507: 503: 499: 498:United States 495: 491: 487: 479:United States 478: 476: 474: 473:pyrophosphate 470: 466: 462: 458: 454: 450: 446: 442: 438: 434: 425: 423: 421: 417: 413: 409: 405: 400: 397: 393: 389: 380: 373: 368: 366: 364: 363: 357: 353: 347: 343: 339: 333: 331: 327: 323: 319: 315: 311: 302: 297: 295: 293: 289: 285: 281: 278: 274: 270: 266: 262: 261:carbohydrates 258: 254: 250: 246: 241: 237: 228: 224: 217: 212: 208: 205: 201: 198: 195: 191: 188: 184: 177: 174: 171: 168: 165: 162: 159: 156: 155: 153: 149: 146: 142: 138: 135: 131: 128: 125: 121: 118: 113: 108: 104: 100: 96: 86: 82: 78: 74: 61: 57: 50: 45: 38: 33: 19: 3660:TWAS fellows 3548: 3484:Bernard Katz 3379: 3247:George Smith 3127:Akira Suzuki 3083:Gerhard Ertl 3067:Yves Chauvin 3015:John B. Fenn 3003:Ryoji Noyori 2990:2001–present 2964:Ahmed Zewail 2924:Harold Kroto 2908:Mario Molina 2836:Robert Huber 2808:John Polanyi 2792:Jerome Karle 2728:Georg Wittig 2624: 2613:Derek Barton 2605:Lars Onsager 2557:Giulio Natta 2553:Karl Ziegler 2545:John Kendrew 2313:Richard Kuhn 2238:Hans Fischer 2054:Otto Wallach 1990:Emil Fischer 1902:. Retrieved 1898: 1889: 1878:. Retrieved 1874: 1865: 1854:. Retrieved 1850: 1841: 1823: 1811: 1800:. Retrieved 1796:the original 1785: 1774:. Retrieved 1770: 1761: 1744:11336/143171 1726: 1722: 1716: 1699:11336/140861 1681: 1677: 1671: 1629:(1): 86–91. 1626: 1622: 1612: 1604: 1589: 1584: 1567:11336/140700 1549: 1545: 1539: 1522:11336/135761 1502: 1498: 1488: 1471: 1467: 1461: 1444:11336/140707 1418: 1414: 1408: 1400: 1395: 1376: 1372: 1362: 1351:. Retrieved 1347:the original 1314:11336/135717 1294: 1290: 1280: 1266: 1254: 1217:. Retrieved 1213:the original 1202: 1183: 1172:. Retrieved 1170:(in Spanish) 1167: 1158: 1141:11336/135573 1121: 1117: 1086:. 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Lee 2772:Henry Taube 2305:Paul Karrer 2293:Peter Debye 2273:Harold Urey 2159:Fritz Pregl 2120:Fritz Haber 2062:Marie Curie 1040:: 202–208. 986:Konex Award 738:Mario Bunge 676:Nobel Prize 649:Later years 574:angiotensin 562:fatty acids 437:mathematics 303:Early years 269:nucleotides 225:(1936–1943) 218:(1944–1945) 213:(1943–1944) 106:Nationality 32:2548 Leloir 18:Luis Leloir 3589:Categories 3453:Louis NĂ©el 3391:Literature 3051:Irwin Rose 3031:Peter Agre 2956:John Pople 2764:Aaron Klug 2669:Paul Flory 2617:Odd Hassel 2541:Max Perutz 2422:Kurt Alder 2418:Otto Diels 2246:Carl Bosch 1904:2022-11-09 1880:2022-11-09 1856:2022-11-09 1802:2007-03-19 1776:2020-10-28 1353:2008-04-12 1219:2007-03-19 1174:2020-10-28 1011:References 947:Elected a 514:Gerty Cori 488:regime in 457:physiology 362:salsa golf 330:Mar de AjĂł 249:biochemist 65:1906-09-06 3372:Chemistry 3365:laureates 2736:Paul Berg 2691:1976–2000 2432:1951–1975 2362:Otto Hahn 2193:1926–1950 1973:1901–1925 1962:Laureates 694:Stockholm 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Index

Luis Leloir
2548 Leloir

Paris
France
Buenos Aires
Argentina
Argentina
Argentine
University of Buenos Aires
Galactosemia
Lactose intolerance
Carbohydrate metabolism
Louisa Gross Horwitz Prize
Nobel Prize in Chemistry
ForMemRS
Legion of Honour
Biochemistry
University of Buenos Aires
Washington University in St. Louis
Columbia University
University of Cambridge
ForMemRS
physician
biochemist
Nobel Prize in Chemistry
metabolic pathways
carbohydrates
University of Buenos Aires
nucleotides

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