1630:
1618:
1605:
494:
350:
1918:
1554:
1827:, a specialized medical care focused on the symptoms, pain, and stress of a serious illness, is recommended by multiple national cancer treatment guidelines as an accompaniment to curative treatments for people with lymphoma. It is used to address both the direct symptoms of lymphoma and many unwanted side effects that arise from treatments. Palliative care can be especially helpful for children who develop lymphoma, helping both children and their families deal with the physical and emotional symptoms of the disease. For these reasons, palliative care is especially important for people requiring bone marrow transplants.
651:
1577:, and IV indicates spread to tissue outside the lymphatic system. Different suffixes imply the involvement of different organs, for example, S for the spleen and H for the liver. Extra-lymphatic involvement is expressed with the letter E. In addition, the presence of B symptoms (one or more of the following: unintentional loss of 10% body weight in the last 6 months, night sweats, or persistent fever of 38 °C or more) or their absence is expressed with B or A, respectively.
1745:. The evidence is very uncertain about the therapeutic effect of mesenchymal stromal cells to treat graft-versus-host diseases on the all-cause mortality and complete disappear of chronic acute graft-versus-host diseases. Mesenchymal stromal cells may result in little to no difference in the all-cause mortality, relapse of malignant disease and incidence of acute and chronic graft-versus-host diseases if they are used for prophylactic reason. Moreover, it was seen that
436:
750:
358:
2014:
1604:
45:
1629:
2053:. Clinical/translational research focuses on studying the disease in a defined and generally immediately applicable way, such as testing a new drug in people. Studies may focus on effective means of treatment, better ways of treating the disease, improving the quality of life for people, or appropriate care in remission or after cures. Hundreds of
550:, which are defined as being all lymphomas except Hodgkin lymphoma, are more common than Hodgkin lymphoma. A wide variety of lymphomas are in this class, and the causes, the types of cells involved, and the prognoses vary by type. The number of cases per year of non-Hodgkin lymphoma increases with age. It is further divided into several subtypes.
1617:
1521:. It excluded the Hodgkin lymphomas and divided the remaining lymphomas into four grades (low, intermediate, high, and miscellaneous) related to prognosis, with some further subdivisions based on the size and shape of affected cells. This purely histological classification included no information about
1835:
Adding physical exercises to the standard treatment for adult patients with haematological malignancies like lymphomas may result in little to no difference in the mortality, the quality of life and the physical functioning. These exercises may result in a slight reduction in depression. Furthermore,
1815:
can be used for the treatment of a
Hodgkin's lymphoma. The evidence is very uncertain about the effect of Nivolumab for patients with a Hodgkin's lymphoma on the overall survival, the quality of life, the survival without a progression, the response rate (=complete disappear) and grade 3 or 4 serious
332:
in the United States for all
Hodgkin lymphoma subtypes is 85%, while that for non-Hodgkin lymphomas is 69%. Worldwide, lymphomas developed in 566,000 people in 2012 and caused 305,000 deaths. They make up 3–4% of all cancers, making them as a group the seventh-most-common form. In children, they are
1572:
is routinely used for staging of both HL and NHL. In this staging system, stage I represents localized disease contained within a lymph node group, II represents the presence of lymphoma in two or more lymph nodes groups, III represents spread of the lymphoma to lymph nodes groups on both sides of
696:
The WHO classification, published in 2001 and updated in 2008, 2017, and 2022, is based upon the foundations laid within the "revised
European–American lymphoma classification" (REAL). This system groups lymphomas by cell type (i.e., the normal cell type that most resembles the tumor) and defining
2060:
Basic science research studies the disease process at a distance, such as seeing whether a suspected carcinogen can cause healthy cells to turn into lymphoma cells in the laboratory or how the DNA changes inside lymphoma cells as the disease progresses. The results from basic research studies are
753:
DNA-microarray analysis of
Burkitt's lymphoma and diffuse large B-cell lymphoma (DLBCL) showing differences in gene expression patterns. Colors indicate levels of expression; green indicates genes that are underexpressed in lymphoma cells (as compared to normal cells), whereas red indicates genes
501:
According to the World Health
Organization (WHO), lymphoma classification should reflect in which lymphocyte population the neoplasm arises. Thus, neoplasms that arise from precursor lymphoid cells are distinguished from those that arise from mature lymphoid cells. Most mature lymphoid neoplasms
1807:
scans between the chemotherapy cycles can be used to make assumptions about the survival. The evidence is very uncertain about the effect of negative (= good prognosis) or positive (= bad prognosis) interim PET scan results on the progression-free survival. Negative interim PET scan results may
1749:
for people undergoing a chemotherapy or a stem cell transplantation for the prevention of bleeding events had different effects on the number of participants with a bleeding event, the number of days on which a bleeding occurred, the mortality secondary to bleeding and the number of platelet
1733:
regimen. A number of people are cured with first-line chemotherapy. Most relapses occur within the first two years, and the relapse risk drops significantly thereafter. For people who relapse, high-dose chemotherapy followed by autologous stem cell transplantation is a proven approach.
1565:. This refers to determining if the cancer has spread, and if so, whether locally or to distant sites. Staging is reported as a grade between I (confined) and IV (spread). The stage of a lymphoma helps predict a patient's prognosis and is used to help select the appropriate therapy.
1728:
Treatment of some other, more aggressive, forms of lymphoma can result in a cure in the majority of cases, but the prognosis for people with a poor response to therapy is worse. Treatment for these types of lymphoma typically consists of aggressive chemotherapy, including the
1800:. Considerable controversy exists regarding the use of ABVD or BEACOPP. Briefly, both regimens are effective, but BEACOPP is associated with more toxicity. Encouragingly, a significant number of people who relapse after ABVD can still be salvaged by stem cell transplant.
1025:
709:
characteristics. The five groups are shown in the table. Hodgkin lymphoma is considered separately within the WHO and preceding classifications, although it is recognized as being a tumor, albeit markedly abnormal, of lymphocytes of mature B cell lineage.
1808:
result in an increase in progression-free survival compared if the adjusted result was measured. Negative interim PET scan results probably result in a large increase in the overall survival compared to those with a positive interim PET scan result.
1060:
5291:
5272:
4317:"Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation"
1536:
In 1994, the
Revised European-American Lymphoma (REAL) classification applied immunophenotypic and genetic features in identifying distinct clinicopathologic entities among all the lymphomas except Hodgkin lymphoma. For coding purposes, the
1661:, a disease wherein these cells' infiltrative lesions are limited to the stomach. These diseases do not progress to cancer, may regress spontaneously and do not respond to, and do not require, chemotherapy or other lymphoma treatments.
1610:
Mantle cell lymphoma: Notice the irregular nuclear contours of the medium-sized lymphoma cells and the presence of a pink histiocyte. By immunohistochemistry, the lymphoma cells expressed CD20, CD5, and Cyclin D1 (high-power view,
1696:
If a low-grade lymphoma becomes symptomatic, radiotherapy or chemotherapy are the treatments of choice. Although these treatments do not permanently cure the lymphoma, they can alleviate the symptoms, particularly painful
2004:
Because the whole lymphatic system is part of the body's immune system, people with a weakened immune system such as from HIV infection or from certain drugs or medication also have a higher number of cases of lymphoma.
2996:
Manli Jiang, N. Nora
Bennani, and Andrew L. Feldman. Lymphoma classification update: T-cell lymphomas, Hodgkin lymphoma, and histiocytic/dendritic cell neoplasms. Expert Rev Hematol. 2017 Mar; 10(3): 239–249. Author
1485:
occurs most often in immunocompromised patients, in particular those with AIDS, but it can occur in the immunocompetent, as well. It has a poor prognosis, particularly in those with AIDS. Treatment can consist of
1020:
3577:
Kirova YM, Piedbois Y, Haddad E, Levy E, Calitchi E, Marinello G, Le
Bourgeois JP (May 1999). "Radiotherapy in the management of mycosis fungoides: indications, results, prognosis. Twenty years experience".
4828:
Schmidt P, Otto M, Hechler T, Metzing S, Wolfe J, Zernikow B (September 2013). "Did increased availability of pediatric palliative care lead to improved palliative care outcomes in children with cancer?".
2327:"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015"
634:
630:
622:
618:
614:
610:
606:
602:
598:
594:
590:
558:
4864:
Tang ST, Chang WC, Chen JS, Wang HM, Shen WC, Li CY, Liao YC (June 2013). "Course and predictors of depressive symptoms among family caregivers of terminally ill cancer patients until their death".
535:
characteristics. A division into
Hodgkin and non-Hodgkin lymphomas is used in several of the older classification systems. A Hodgkin lymphoma is marked by the presence of a type of cell called the
463:
features that may indicate lymphoma. After lymphoma is diagnosed, a variety of tests may be carried out to look for specific features characteristic of different types of lymphoma. These include:
2278:"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015"
502:
comprise the non-Hodgkin lymphomas. Historically, mature histiocytic and dendritic cell (HDC) neoplasms have been considered mature lymphoid neoplasms, since these often involve lymphoid tissue.
4223:"Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition"
5374:
2453:
493:
5404:
1598:
are other established poor prognostic factors. This means that people who are elderly or too sick to take care of themselves are more likely to be killed by lymphoma than others.
439:
An initial evaluation of a suspected lymphoma is to make a "touch prep" wherein a glass slide is lightly pressed against excised lymphoid tissue, and subsequently stained (usually
2061:
generally less immediately useful to people with the disease, but can improve scientists' understanding of lymphoma and form the foundation for future, more effective treatments.
365:
Lymphoma may present with certain nonspecific symptoms; if the symptoms are persistent, an evaluation to determine their cause, including possible lymphoma, should be undertaken.
5303:
4785:
Heath JA, Clarke NE, Donath SM, McCarthy M, Anderson VA, Wolfe J (January 2010). "Symptoms and suffering at the end of life in children with cancer: an
Australian perspective".
3721:
4666:
3240:
Naresh KN, Medeiros LJ (December 2023). "Introduction to the Fifth Edition of the World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissues".
1218:
1035:
1994:
Taken together, lymphomas represent 5.3% of all cancers (excluding simple basal cell and squamous cell skin cancers) in the United States and 55.6% of all blood cancers.
2174:
2837:
255:
204:
2577:
Hu L, Luo D, Zhou T, Tao Y, Feng J, Mei S (December 2017). "The association between non-Hodgkin lymphoma and organophosphate pesticides exposure: A meta-analysis".
1591:-avid lymphomas, such as Hodgkin lymphoma, as a staging tool that can even replace bone marrow biopsy. For other lymphomas, CT scanning is recommended for staging.
1448:
2117:
5367:
349:
2024:
published the first description of lymphoma in 1832, specifically of the form named after him. Since then, many other forms of lymphoma have been described.
2276:
Allen C, Arora M, Barber RM, Bhutta ZA, Brown A, Carter A, et al. (GBD 2015 Disease and Injury Incidence and Prevalence Collaborators) (October 2016).
5568:
1917:
4272:"Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after chemotherapy and stem cell transplantation"
3717:
3123:
2201:"Cigarette smoking and risk of Hodgkin lymphoma and its subtypes: a pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph)"
941:
660:
4221:
Fisher SA, Cutler A, Doree C, Brunskill SJ, Stanworth SJ, Navarrete C, Girdlestone J (January 2019). Cochrane Haematological Malignancies Group (ed.).
5360:
1689:(growing slowly or not at all) for many years – sometimes, for the rest of the person's life. With an indolent lymphoma, such as follicular lymphoma,
1646:
1135:
1120:
5207:
320:, and surgery. In some non-Hodgkin lymphomas, an increased amount of protein produced by the lymphoma cells causes the blood to become so thick that
5575:
845:
3042:
3811:
Carbone PP, Kaplan HS, Musshoff K, Smithers DW, Tubiana M (November 1971). "Report of the Committee on Hodgkin's Disease Staging Classification".
2530:"The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes"
2444:
1738:
1673:
of tumour, referring to how quickly a cancer replicates. Paradoxically, high-grade lymphomas are more readily treated and have better prognoses:
1635:
Hodgkin lymphoma, nodular lymphocyte predominant (high-power view): Notice the presence of L&H cells, also known as "popcorn cells". (H&E)
1482:
1283:
1278:
1510:
Several previous classifications have been used, including Rappaport 1956, Lennert/Kiel 1974, BNLI, Working formulation (1982), and REAL (1994).
328:
may be appropriate for certain types. The outcome depends on the subtype, with some being curable and treatment prolonging survival in most. The
4571:
Goldkuhle M, Dimaki M, Gartlehner G, Monsef I, Dahm P, Glossmann JP, et al. (July 2018). Cochrane Haematological Malignancies Group (ed.).
5501:
5424:
2866:
2669:
Solimini AG, Lombardi AM, Palazzo C, De Giusti M (May 2016). "Meat intake and non-Hodgkin lymphoma: a meta-analysis of observational studies".
1650:
1140:
4680:
4662:
4389:
Martin NE, Ng AK (November 2009). "Good things come in small packages: low-dose radiation as palliation for indolent non-Hodgkin lymphomas".
3622:
3516:
3341:
2821:
2792:
2765:
2419:
1314:
4270:
Estcourt L, Stanworth S, Doree C, Hopewell S, Murphy MF, Tinmouth A, Heddle N (May 2012). Cochrane Haematological Malignancies Group (ed.).
2001:, lymphomas account for about 5%, and Hodgkin lymphoma in particular accounts for less than 1% of all cases of cancer in the United States.
1553:
5592:
4182:"Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma"
2968:
1836:
aerobic physical exercises probably reduce fatigue. The evidence is very uncertain about the effect on anxiety and serious adverse events.
5068:
Table 1.4: Age-Adjusted SEER Incidence and U.S. Death Rates and 5-Year Relative Survival Rates By Primary Cancer Site, Sex and Time Period
4315:
Estcourt LJ, Stanworth SJ, Doree C, Hopewell S, Trivella M, Murphy MF (November 2015). Cochrane Haematological Malignancies Group (ed.).
3764:"Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification"
1623:
Hodgkin lymphoma, nodular lymphocyte predominant (low-power view): Notice the nodular architecture and the areas of "mottling". (H&E)
725:, therefore, depends on the correct diagnosis and classification of the disease, which is established after examination of a biopsy by a
2798:
1040:
886:
759:
593:, the World Health Organization (2016) includes the following lymphomas, when associated with EBV infection, in this group of diseases:
4524:"Interim PET-results for prognosis in adults with Hodgkin lymphoma: a systematic review and meta-analysis of prognostic factor studies"
2907:
2622:"Red and Processed Meat Consumption Increases Risk for Non-Hodgkin Lymphoma: A PRISMA-Compliant Meta-Analysis of Observational Studies"
2425:
786:
Occurs in older adults, usually involves lymph nodes, bone marrow and spleen, most patients have peripheral blood involvement, indolent
5558:
3640:"Expert review of non-Hodgkin's lymphomas in a population-based cancer registry: reliability of diagnosis and subtype classifications"
1245:
626:
477:
5186:
5585:
5518:
5513:
5454:
5449:
5148:
2392:
1750:
transfusions depending on the way they were used (therapeutic, depending on a threshold, different dose schedules or prophylactic).
1288:
4975:
Knips L, Bergenthal N, Streckmann F, Monsef I, Elter T, Skoetz N (January 2019). Cochrane Haematological Malignancies Group (ed.).
3007:
Canova F, Marino D, Trentin C, SoldĂ C, Ghiotto C, Aversa SM (August 2011). "Intrathecal chemotherapy in lymphomatous meningitis".
1093:
Endemic in Africa, sporadic elsewhere, more common in immunocompromised and children, often visceral involvement, highly aggressive
721:), causing rapid deterioration and death. However, most of the aggressive lymphomas respond well to treatment and are curable. The
4684:
3696:
3092:
3961:"A Systematic Review on Childhood Non-Hodgkin Lymphoma: An Overlooked Phenomenon in the Health and Research Sector of Bangladesh"
3277:"A Systematic Review on Childhood Non-Hodgkin Lymphoma: An Overlooked Phenomenon in the Health and Research Sector of Bangladesh"
3140:"A Systematic Review on Childhood Non-Hodgkin Lymphoma: An Overlooked Phenomenon in the Health and Research Sector of Bangladesh"
802:
3347:
2730:
5632:
5469:
5444:
3369:
1658:
1654:
5024:
4522:
Aldin A, Umlauff L, Estcourt LJ, Collins G, Moons KG, Engert A, et al. (January 2020). Cochrane Haematology Group (ed.).
3090:
National Cancer Institute. "What You Need To Know About Hodgkin Lymphoma". U.S. Dept of Health and Human Services, (online at
3069:
2166:
1788:
Advanced Hodgkin disease requires systemic chemotherapy, sometimes combined with radiotherapy. Chemotherapy used includes the
301:
may then be done to determine if and where the cancer has spread. Lymphoma most often spreads to the lungs, liver, and brain.
5563:
5533:
5484:
5479:
5434:
5419:
2255:
1264:
1258:
1254:
1250:
1206:
1130:
1115:
808:
793:
3522:
1653:) can be mimicked by two benign diseases that involve the excessive proliferation of nonmalignant NK cells in the GI tract,
2812:
Tepper John E. Niederhuber, James O. Armitage, James H. Doroshow, Michael B. Kastan, Joel E. (2014). "Childhood lymphoma".
5663:
5607:
5439:
4954:
3197:
Rezk SA, Zhao X, Weiss LM (September 2018). "Epstein-Barr virus (EBV)-associated lymphoid proliferations, a 2018 update".
2506:
1998:
1145:
984:
4145:
Jenkins EC (January 1972). "Wire-loop application of liquid emulsion to slides for autoradiography in light microscopy".
2109:
5637:
5548:
5459:
4764:
1804:
1792:
regimen, which is commonly used in the United States. Other regimens used in the management of Hodgkin lymphoma include
1298:
970:
278:
5528:
5491:
5474:
1125:
1045:
1030:
5104:
Tran H, Nourse J, Hall S, Green M, Griffiths L, Gandhi MK (September 2008). "Immunodeficiency-associated lymphomas".
3327:
5673:
5612:
5508:
5055:
4102:
Bernstein SH, Burack WR (2009). "The incidence, natural history, biology, and treatment of transformed lymphomas".
798:
714:
274:
5597:
5245:
5051:
1770:
1742:
1669:
Prognoses and treatments are different for HL and between all the different forms of NHL, and also depend on the
1055:
927:
4622:"The national agenda for quality palliative care: the National Consensus Project and the National Quality Forum"
650:
5627:
5538:
5496:
5464:
5414:
5311:
3538:"Burkitt lymphoma in adults: a prospective study of 72 patients treated with an adapted pediatric LMB protocol"
1988:
1758:
1693:
is often the initial course of action, because monitoring is less risky and less harmful than early treatment.
1150:
3885:"NK-Cell Enteropathy and Similar Indolent Lymphoproliferative Disorders: A Case Series With Literature Review"
536:
378:(systemic symptoms) – can be associated with both Hodgkin lymphoma and non-Hodgkin lymphoma. They consist of:
1701:. People with these types of lymphoma can live near-normal lifespans, even though the disease is technically
589:(EBV). The virus may be responsible for the development and/or progression of these diseases. In addition to
5617:
5580:
5553:
5543:
1762:
1182:
1172:
1007:
381:
329:
3138:
Britto TI, Fattah SA, Rahman MA, Chowdhury MA, Britto TI, Fattah SA, Rahman MA, Chowdhury MA (2023-09-25).
1657:, a disease wherein NK cell infiltrative lesions occur in the intestine, colon, stomach, or esophagus, and
1428:
586:
265:
and a history of the disease in the family. Risk factors for common types of non-Hodgkin lymphomas include
262:
112:
5622:
5429:
5409:
5399:
5218:
4713:"What is the evidence that palliative care teams improve outcomes for cancer patients and their families?"
2046:
1677:, for example, is a high-grade tumour known to double within days, and is highly responsive to treatment.
1302:
1211:
1050:
866:
772:
506:
294:
1311:
with irregular nuclear contours, condensed chromatin, small nucleoli and scant cytoplasm without granules
1189:
5602:
2936:
1588:
1078:
2199:
Kamper-Jørgensen M, Rostgaard K, Glaser SL, Zahm SH, Cozen W, Smedby KE, et al. (September 2013).
1065:
926:
Occurs in older adults, usually involves lymph nodes, bone marrow and spleen, associated with t(14;18)
718:
4951:"Providing Palliative Care to Family Caregivers Throughout the Bone Marrow Transplantation Trajectory"
1741:. It was evaluated whether mesenchymal stromal cells can be used for the treatment and prophylaxis of
771:
Small resting lymphocytes mixed with variable numbers of large activated cells, lymph nodes diffusely
527:
Hodgkin lymphoma accounts for about 15% of lymphomas. It differs from other forms of lymphomas in its
5164:
3448:
Herrmann A, Hoster E, Zwingers T, Brittinger G, Engelhard M, Meusers P, et al. (February 2009).
2586:
1774:
1746:
1522:
1518:
1381:
Reed–Sternberg cell variants and inflammation, usually broad sclerotic bands that consist of collagen
946:
838:
547:
243:
4180:
Philip T, Guglielmi C, Hagenbeek A, Somers R, Van der Lelie H, Bron D, et al. (December 1995).
2862:
5668:
5295:
5080:
2070:
1730:
1514:
1427:
Most common in men, more likely to be diagnosed at advanced stages than the nodular sclerosis form
1398:
1107:
891:
824:
813:
52:
4660:*The American Society of Clinical Oncology made this recommendation based on various cancers. See
3762:
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA (September 2014).
1171:
Usually small lymphoid cells with convoluted nuclei that often infiltrate the epidermis, creating
4932:
4889:
4810:
4742:
4504:
4414:
4365:
4127:
4049:
3914:
3736:"2022 ICD-10-CM Codes C81-C96: Malignant neoplasms of lymphoid, hematopoietic and related tissue"
3479:
3222:
2831:
2704:
2559:
2472:
1737:
The treatment of side effects is also important as they can occur due to the chemotherapy or the
1595:
1574:
407:
266:
236:
175:
116:
100:
79:
4573:"Nivolumab for adults with Hodgkin's lymphoma (a rapid review using the software RobotReviewer)"
4473:
Viviani S, Zinzani PL, Rambaldi A, Brusamolino E, Levis A, Bonfante V, et al. (July 2011).
3536:
Diviné M, Casassus P, Koscielny S, Bosq J, Sebban C, Le Maignan C, et al. (December 2005).
2964:
1159:
1013:
Occurs in all ages, but most commonly in older adults, may occur outside lymph nodes, aggressive
717:), compatible with a long life even without treatment, whereas other forms are aggressive (e.g.
1188:
Localized or more generalized skin symptoms, generally indolent, in a more aggressive variant,
5658:
5340:
5144:
5121:
5006:
4924:
4881:
4846:
4802:
4734:
4643:
4602:
4553:
4496:
4455:
4406:
4346:
4297:
4252:
4203:
4162:
4119:
4084:
4041:
4000:
3982:
3941:
3906:
3861:
3820:
3793:
3711:
3661:
3618:
3595:
3559:
3512:
3471:
3435:
3337:
3308:
3257:
3214:
3179:
3161:
3117:
3024:
2817:
2788:
2761:
2696:
2651:
2602:
2551:
2528:
Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, et al. (July 2009).
2415:
2388:
2356:
2307:
2230:
1686:
1569:
1366:
1155:
467:
452:
412:
372:
or swelling of lymph nodes, is the primary presentation in lymphoma. It is generally painless.
309:
290:
150:
136:
131:
63:
5352:
5113:
4996:
4988:
4916:
4873:
4838:
4794:
4724:
4633:
4592:
4584:
4543:
4535:
4486:
4445:
4398:
4336:
4328:
4287:
4279:
4242:
4234:
4193:
4154:
4111:
4076:
4031:
3990:
3972:
3896:
3880:
3851:
3783:
3775:
3651:
3587:
3549:
3461:
3425:
3298:
3288:
3249:
3206:
3169:
3151:
3016:
2903:
2782:
2686:
2678:
2641:
2633:
2594:
2541:
2409:
2384:
2378:
2346:
2338:
2297:
2289:
2220:
2212:
1766:
1713:
1690:
1674:
1360:
1328:
1233:
522:
444:
435:
338:
325:
317:
247:
212:
158:
5182:
1785:
Hodgkin lymphoma typically is treated with radiotherapy alone, as long as it is localized.
4675:
3735:
2949:
2928:
2484:
2054:
1824:
1698:
1530:
1526:
1487:
1238:
Probably consists of several rare tumor types, often disseminated and generally aggressive
730:
369:
334:
298:
289:
may also increase the risk. Diagnosis, if enlarged lymph nodes are present, is usually by
286:
220:
124:
84:
3679:
3383:
3995:
3960:
3303:
3276:
3174:
3139:
3099:
2590:
1761:(for relapsed or refractory large B-cell lymphoma with two failed systemic treatments),
749:
5001:
4976:
4798:
4620:
Ferrell B, Connor SR, Cordes A, Dahlin CM, Fine PG, Hutton N, et al. (June 2007).
4597:
4572:
4548:
4523:
4341:
4316:
4292:
4271:
4247:
4222:
3788:
3763:
2646:
2621:
2351:
2326:
2302:
2277:
2225:
2200:
2050:
2021:
1670:
1562:
918:
778:
566:
472:
460:
321:
313:
154:
4638:
4621:
4080:
3591:
2342:
2293:
357:
239:. The enlarged lymph nodes are usually painless. The sweats are most common at night.
5652:
3331:
3020:
1230:
Variable, usually a mix small to large lymphoid cells with irregular nuclear contours
961:
849:
677:
667:
5028:
4936:
4893:
4746:
4508:
4450:
4433:
4418:
4131:
4115:
4053:
3918:
3483:
3361:
3226:
3065:
2708:
2013:
969:
Occurs mainly in adult males, usually involves lymph nodes, bone marrow, spleen and
879:
Frequently occurs outside lymph nodes, very indolent, may be cured by local excision
5384:
4992:
4814:
4588:
4539:
4332:
4283:
4238:
3412:
Leitch HA, Gascoyne RD, Chhanabhai M, Voss NJ, Klasa R, Connors JM (October 2003).
2563:
2251:
1495:
1491:
1476:
830:
671:
562:
386:
305:
242:
Many subtypes of lymphomas are known. The two main categories of lymphomas are the
146:
4067:
Ansell SM (April 2014). "Follicular lymphoma: watch and wait is watch and worry".
3838:
International Non-Hodgkin's Lymphoma Prognostic Factors Project (September 1993).
3656:
3639:
3210:
2722:
1716:
is not a desirable strategy for everyone, as it leads to significant distress and
1533:. It was widely accepted at the time of its publication but by 2004 was obsolete.
1026:
Epstein–Barr virus positive diffuse large B-cell lymphoma, not otherwise specified
440:
5316:
4729:
4712:
3511:. Vol. 936 (4 ed.). Lippincott Williams & Wilkins. pp. 285–6.
3506:
3253:
2598:
2546:
2529:
1712:
in the treatment of follicular lymphoma rather than the wait-and-watch approach.
1061:
Large B-cell lymphoma arising in HHV8-associated multicentric Castleman's disease
997:
Variable, most resemble B cells of large germinal centers, diffuse growth pattern
5523:
5335:
4198:
4181:
3932:
Sweetenham JW (November 2009). "Treatment of lymphoblastic lymphoma in adults".
3856:
3839:
3638:
Clarke CA, Glaser SL, Dorfman RF, Bracci PM, Eberle E, Holly EA (January 2004).
2637:
2498:
1394:
1308:
908:
862:
818:
706:
391:
228:
107:
92:
5117:
4977:"Aerobic physical exercise for adult patients with haematological malignancies"
4950:
17:
4475:"ABVD versus BEACOPP for Hodgkin's lymphoma when high-dose salvage is planned"
4402:
4158:
2682:
1797:
1754:
1342:
904:
698:
582:
456:
375:
208:
68:
56:
4760:
4020:"Understanding the concept of uncertainty in patients with indolent lymphoma"
3986:
3779:
3466:
3449:
3165:
5285:
5281:
3684:
3554:
3537:
3430:
3413:
3388:
2620:
Yang L, Dong J, Jiang S, Shi W, Xu X, Huang H, et al. (November 2015).
2216:
1812:
1709:
1702:
1082:
974:
726:
722:
702:
532:
528:
282:
169:
44:
5125:
5010:
4928:
4907:
Chung HM, Lyckholm LJ, Smith TJ (February 2009). "Palliative care in BMT".
4885:
4850:
4806:
4738:
4647:
4606:
4557:
4500:
4459:
4410:
4350:
4301:
4256:
4123:
4088:
4045:
4036:
4019:
4004:
3945:
3910:
3797:
3665:
3599:
3563:
3475:
3439:
3312:
3261:
3218:
3183:
3028:
2700:
2655:
2606:
2555:
2360:
2311:
2234:
4842:
4491:
4474:
4207:
4166:
3901:
3884:
3865:
3824:
5043:
4920:
3977:
3293:
3156:
1587:
imaging modalities are used to stage cancer. PET scanning is advised for
1584:
1193:
578:
510:
270:
251:
232:
120:
96:
72:
3450:"Improvement of overall survival in advanced stage mantle cell lymphoma"
2691:
1921:
Deaths from lymphomas and multiple myeloma per million persons in 2012
1793:
1717:
1580:
574:
570:
422:
417:
162:
5264:
1284:
B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities
713:
Of the many forms of lymphoma, some are categorized as indolent (e.g.
219:
versions rather than all such tumours. Signs and symptoms may include
5276:
5249:
4877:
1337:
1332:
1203:
Primary cutaneous CD30-positive T-cell lymphoproliferative disorders
1103:
742:
401:
216:
958:
Lymphocytes of small to intermediate size growing in diffuse pattern
1777:). These therapies come with certification and other restrictions.
1916:
1552:
1538:
1021:
Diffuse large B-cell lymphoma associated with chronic inflammation
931:
748:
603:
diffuse large B cell lymphoma associated with chronic inflammation
492:
434:
356:
348:
224:
88:
1077:
Round lymphoid cells of intermediate size with several nucleoli,
1789:
1388:
1384:
1001:
914:
873:
585:) in which one or more of these cell types is infected with the
5356:
1757:
therapies are FDA-approved for non-Hodgkin lymphoma, including
1542:
1466:
1322:
1318:
1177:
644:
497:
Lymph node with mantle cell lymphoma (low-power view, H&E)
4438:
Hematology. American Society of Hematology. Education Program
4104:
Hematology. American Society of Hematology. Education Program
3330:. In Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (eds.).
3613:
Jaffe ES, Harris NL, Vardiman JW, Campo E, Arber D (2011).
333:
the third-most-common cancer. They occur more often in the
3840:"A predictive model for aggressive non-Hodgkin's lymphoma"
3275:
Britto TI, Fattah SA, Rahman M, Chowdhury M (2023-09-25).
2787:(Second ed.). Cambridge University Press. p. 1.
2760:. World Health Organization. 2014. pp. Chapter 5.13.
2446:
The Lymphoma Guide Information for Patients and Caregivers
869:
of B cells to epithelium creates lymphoepithelial lesions.
559:
Epstein–Barr virus-associated lymphoproliferative diseases
554:
Epstein–Barr virus-associated lymphoproliferative diseases
5183:"Search of: Lymphoma - List Results - ClinicalTrials.gov"
1457:
Immunodeficiency-associated lymphoproliferative disorders
1279:
B-lymphoblastic leukemia/lymphoma not otherwise specified
261:
Risk factors for Hodgkin lymphoma include infection with
2929:"Primary CNS Lymphoma: Overview, Etiology, Epidemiology"
973:, associated with t(11;14) translocation overexpressing
459:
examined under the microscope. This examination reveals
4366:"New CAR-T for Aggressive B-Cell Lymphoma Wins FDA Nod"
760:
B-cell chronic lymphocytic leukemia/small cell lymphoma
4761:"Palliative Care: It's for Caregivers Too, Says Study"
3959:
Britto TI, Fattah SA, Rahman MA, Chowdhury MA (2023).
3398:
3396:
2167:"General Information About Adult Non-Hodgkin Lymphoma"
1720:
in some people. It has been called "watch and worry".
1265:
Breast plant-associated anaplastic large cell lymphoma
4667:"Five Things Physicians and Patients Should Question"
2904:"Warning Signs of Lymphoma — First Signs of Lymphoma"
2898:
2896:
2894:
2892:
2890:
2888:
2886:
2884:
353:
The lymph nodes where lymphoma most commonly develops
5254:
304:
Treatment may involve one or more of the following:
5392:
5326:
5258:
2045:The two types of lymphoma research are clinical or
1557:
Diagram showing common sites where lymphoma spreads
623:
peripheral T cell lymphoma, not otherwise specified
190:
182:
168:
142:
130:
106:
78:
62:
37:
2784:Lymphoma : pathology, diagnosis and treatment
2110:"General Information About Adult Hodgkin Lymphoma"
2057:are being planned or conducted at any given time.
1847:Five-year relative survival by stage at diagnosis
1561:After a diagnosis and before treatment, cancer is
1465:Associated with the human immunodeficiency virus (
1421:Many classic Reed–Sternberg cells and inflammation
1219:Peripheral T-cell lymphoma not otherwise specified
1036:Primary mediastinal (thymic) large B-cell lymphoma
404:, bleeding, increased susceptibility to infections
5208:"Understanding Clinical Trials for Blood Cancers"
2383:(29th ed.). Philadelphia: Saunders. p.
1393:Most common in young adults, often arises in the
861:Variable cell size and differentiation, 40% show
5143:. Lippincott Williams & Wilkins. p. 5.
5139:Hellman S, Mauch, P.M. Ed. (1999). "Chapter 1".
5048:Surveillance Epidemiology and End Results (SEER)
3644:Cancer Epidemiology, Biomarkers & Prevention
2816:(Fifth ed.). Elsevier. p. Chapter 97.
1207:Primary cutaneous anaplastic large cell lymphoma
911:), usually nodular ("follicular") growth pattern
256:tumors of the hematopoietic and lymphoid tissues
254:and myelomas are a part of the broader group of
5217:. Leukemia and Lymphoma Society. Archived from
4706:
4704:
4434:"Standard therapy of advanced Hodgkin lymphoma"
3720:) CS1 maint: bot: original URL status unknown (
3333:Cancer Management: A Multidisciplinary Approach
3063:National Cancer Institute, "Hodgkin Lymphoma",
2857:
2855:
2853:
2851:
2849:
2847:
1449:Nodular lymphocyte-predominant Hodgkin lymphoma
607:fibrin-associated diffuse large B cell lymphoma
1708:Some centers advocate the use of single agent
1651:type II enteropathy-associated T-cell lymphoma
599:large B cell lymphoma, not otherwise specified
5368:
3699:. Archived from the original on June 27, 2004
2723:"SEER Stat Fact Sheets: Non-Hodgkin Lymphoma"
2439:
2437:
2435:
1991:, or "blood cancer", in the developed world.
835:Monoclonal immunoglobulin deposition diseases
8:
2836:: CS1 maint: multiple names: authors list (
2414:. Jones & Bartlett Learning. p. 6.
1846:
1525:or genetics and made no distinction between
4981:The Cochrane Database of Systematic Reviews
4577:The Cochrane Database of Systematic Reviews
4528:The Cochrane Database of Systematic Reviews
4321:The Cochrane Database of Systematic Reviews
4276:The Cochrane Database of Systematic Reviews
4227:The Cochrane Database of Systematic Reviews
2028:
1418:Second-most common form of Hodgkin lymphoma
455:, meaning a partial or total excision of a
27:Hematologic cancer that affects lymphocytes
5375:
5361:
5353:
5255:
5044:"SEER Cancer Statistics Review, 1975–2006"
3508:Clinical Hematology: Theory and Procedures
2752:
2750:
2748:
2161:
2159:
2157:
2155:
1878:Regional (spread to regional lymph nodes)
942:Primary cutaneous follicle center lymphoma
676:. Relevant discussion may be found on the
43:
34:
5042:Horner MJ, Ries LG, Krapcho M, Neyman N.
5000:
4728:
4637:
4596:
4547:
4490:
4449:
4340:
4291:
4246:
4197:
4035:
3994:
3976:
3900:
3883:, Ferry JA, Zukerberg LR (January 2019).
3855:
3787:
3757:
3755:
3655:
3553:
3465:
3429:
3302:
3292:
3173:
3155:
2690:
2645:
2545:
2411:Johns Hopkins Patients' Guide to Lymphoma
2350:
2301:
2224:
2194:
2192:
2153:
2151:
2149:
2147:
2145:
2143:
2141:
2139:
2137:
2135:
2104:
1647:extranodal NK/T-cell lymphoma, nasal type
1462:Associated with a primary immune disorder
1168:Most common cutaneous lymphoid malignancy
1136:Extranodal NK/T-cell lymphoma, nasal type
1121:T-cell large granular lymphocyte leukemia
1074:< 1% of lymphomas in the United States
754:that are overexpressed in lymphoma cells.
619:extranodal NK/T cell lymphoma, nasal type
513:, known as lymphomatous meningitis (LM).
215:). The name typically refers to just the
5405:Attention deficit hyperactivity disorder
2380:Dorland's Illustrated medical dictionary
2252:"Hodgkin Lymphoma—SEER Stat Fact Sheets"
2102:
2100:
2098:
2096:
2094:
2092:
2090:
2088:
2086:
2084:
2012:
1843:
846:Extranodal marginal zone B cell lymphoma
451:Lymphoma is definitively diagnosed by a
3009:Critical Reviews in Oncology/Hematology
2372:
2370:
2080:
1600:
1483:Primary central nervous system lymphoma
285:. Eating large amounts of red meat and
5058:from the original on 26 September 2009
4674:Choosing Wisely: an initiative of the
4626:Journal of Pain and Symptom Management
3889:American Journal of Clinical Pathology
3716:: CS1 maint: archived copy as title (
3709:
3122:: CS1 maint: archived copy as title (
3115:
2945:
2934:
2829:
2480:
2470:
2246:
2244:
1141:Enteropathy-associated T-cell lymphoma
4681:American Society of Clinical Oncology
4663:American Society of Clinical Oncology
2992:
2990:
2988:
2986:
1867:Localized (confined to primary site)
635:systemic T cell lymphoma of childhood
297:may also be useful in the diagnosis.
7:
3414:"Limited-stage mantle-cell lymphoma"
2971:from the original on 16 January 2013
2869:from the original on 2 December 2012
2325:Wang H, et al. (October 2016).
1987:Lymphoma is the most common form of
1378:Most common type of Hodgkin lymphoma
1081:by diffuse spread with interspersed
907:) mixed with large activated cells (
324:is performed to remove the protein.
5502:Epidemiology of Alzheimer's disease
5215:The Leukemia & Lymphoma Society
4479:The New England Journal of Medicine
4186:The New England Journal of Medicine
3844:The New England Journal of Medicine
3617:(1st ed.). Elsevier Saunders.
1811:Current research evaluated whether
1443:Lymphocyte depleted or not depleted
1041:Intravascular large B-cell lymphoma
994:About 40–50% of lymphomas in adults
887:Nodal marginal zone B cell lymphoma
4799:10.5694/j.1326-5377.2010.tb03420.x
2027:The term "lymphoma" is from Latin
1999:U.S. National Institutes of Health
1889:Distant (cancer has metastasized)
1409:Mixed cellularity Hodgkin lymphoma
1246:Angioimmunoblastic T-cell lymphoma
627:angioimmunoblastic T-cell lymphoma
25:
5025:"SEER Stat Fact Sheets: Lymphoma"
4639:10.1016/j.jpainsymman.2007.02.024
3328:"Principles of Surgical Oncology"
2459:from the original on 14 July 2014
1769:(for large B-cell lymphoma), and
1341:mutations, and is most common in
1289:T-lymphoblastic leukemia/lymphoma
955:About 3–4% of lymphomas in adults
4787:The Medical Journal of Australia
3525:from the original on 2015-09-06.
3372:from the original on 2010-07-04.
3350:from the original on 2013-10-04.
3021:10.1016/j.critrevonc.2010.07.005
2865:. Lymphoma Research Foundation.
2801:from the original on 2015-09-06.
2733:from the original on 6 July 2014
2509:from the original on 5 July 2014
2428:from the original on 2017-09-10.
2177:from the original on 5 July 2014
2120:from the original on 5 July 2014
1755:chimeric antigen receptor T cell
1685:Many low-grade lymphomas remain
1628:
1616:
1603:
1517:of 1982 was a classification of
1196:and peripheral blood involvement
900:About 40% of lymphomas in adults
827:(also known as multiple myeloma)
649:
509:, often around the brain in the
505:Lymphoma can also spread to the
5189:from the original on 2013-01-06
4957:from the original on 2013-08-12
4767:from the original on 2014-06-01
4711:Higginson IJ, Evans CJ (2010).
4451:10.1182/asheducation-2009.1.497
4116:10.1182/asheducation-2009.1.532
3072:from the original on 2013-08-02
2910:from the original on 2012-11-18
2258:from the original on 2012-10-17
1905:
1902:
1899:
1894:
1891:
1888:
1883:
1880:
1877:
1872:
1869:
1866:
1859:
1854:
1851:
1655:natural killer cell enteropathy
1545:(codes C81-C96) are available.
1335:. It is highly associated with
858:About 5% of lymphomas in adults
418:Respiratory distress or dyspnea
4993:10.1002/14651858.CD009075.pub3
4831:Journal of Palliative Medicine
4589:10.1002/14651858.CD012556.pub2
4540:10.1002/14651858.CD012643.pub3
4333:10.1002/14651858.CD010983.pub2
4284:10.1002/14651858.CD004269.pub3
4239:10.1002/14651858.CD009768.pub2
3366:The Merck Manual of Geriatrics
1331:because of involvement of the
1251:Anaplastic large cell lymphoma
1131:Adult T-cell leukemia/lymphoma
1116:T-cell prolymphocytic leukemia
809:Splenic marginal zone lymphoma
794:B-cell prolymphocytic leukemia
663:of this section is in question
591:EBV-positive Hodgkin lymphomas
1:
4081:10.1016/S1470-2045(14)70066-X
3657:10.1158/1055-9965.EPI-03-0250
3592:10.1016/S0167-8140(99)00050-X
3211:10.1016/j.humpath.2018.05.020
3043:"Hodgkins Lymphoma Incidence"
2343:10.1016/s0140-6736(16)31012-1
2294:10.1016/S0140-6736(16)31678-6
1803:Scientists evaluated whether
1146:Hepatosplenic T-cell lymphoma
985:Diffuse large B-cell lymphoma
803:Waldenström macroglobulinemia
670:can not read content that is
361:Lymphoma and lymphatic system
279:immunosuppressant medications
4730:10.1097/PPO.0b013e3181f684e5
3879:Xia D, Morgan EA, Berger D,
3768:Journal of Clinical Oncology
3454:Journal of Clinical Oncology
3336:(11th ed.). CMPMedica.
3254:10.1016/j.modpat.2023.100330
2965:"How Is Lymphoma Diagnosed?"
2599:10.1016/j.envpol.2017.08.028
2547:10.1182/blood-2009-03-209262
1805:positron emission tomography
1299:acute lymphoblastic leukemia
1273:Precursor lymphoid neoplasms
736:Lymphoma subtypes (WHO 2008)
565:, and malignant diseases of
408:Loss of appetite or anorexia
5169:Online Etymology Dictionary
4909:Bone Marrow Transplantation
4199:10.1056/nejm199512073332305
3857:10.1056/NEJM199309303291402
2814:Abeloff's clinical oncology
2671:Cancer Causes & Control
2638:10.1097/MD.0000000000001729
1227:Most common T cell lymphoma
1126:Aggressive NK cell leukemia
1090:Five-year survival rate 50%
1031:Lymphomatoid granulomatosis
768:3–4% of lymphomas in adults
583:histiocytic-dendritic cells
5690:
5118:10.1016/j.blre.2008.03.009
3066:"Lymphoma—Patient Version"
2068:
2037:("morbid growth, tumor").
1743:graft-versus-host diseases
1498:, often with methotrexate.
1046:ALK+ large B-cell lymphoma
799:Lymphoplasmacytic lymphoma
715:small lymphocytic lymphoma
631:follicular T cell lymphoma
520:
275:human T-lymphotropic virus
231:, unintended weight loss,
95:, unintended weight loss,
5052:National Cancer Institute
4403:10.3109/10428190903186510
4159:10.3109/10520297209116530
3580:Radiotherapy and Oncology
2683:10.1007/s10552-016-0745-2
2171:National Cancer Institute
2114:National Cancer Institute
2033:("water") and from Greek
1771:brexucabtagene autoleucel
1739:stem cell transplantation
1173:Pautrier microabscesseses
1066:Burkitt lymphoma/leukemia
1056:Primary effusion lymphoma
987:, not otherwise specified
783:5-year survival rate 50%.
665:. The specific issue is:
611:primary effusion lymphoma
246:(NHL) (90% of cases) and
51:
42:
5576:Motor vehicle collisions
3780:10.1200/JCO.2013.54.8800
3467:10.1200/JCO.2008.16.8435
3446:70% for advanced stage:
3081:, accessed on 2013-08-05
2758:World Cancer Report 2014
1989:hematological malignancy
1759:lisocabtagene maraleucel
1659:lymphomatoid gastropathy
1570:Ann Arbor staging system
1506:Previous classifications
1431:involved in 70% of cases
1369:form of Hodgkin lymphoma
1151:Blastic NK cell lymphoma
903:Small "cleaved" cells (
250:(HL) (10%). Lymphomas,
5085:American Cancer Society
4391:Leukemia & Lymphoma
4364:Ingram I (2021-02-05).
3410:50% for limited stage:
2579:Environmental Pollution
1763:axicabtagene ciloleucel
1327:It often presents as a
1008:Five-year survival rate
1000:Variable expression of
977:, moderately aggressive
561:are a group of benign,
443:) for evaluation under
330:five-year survival rate
5425:Cardiovascular disease
4037:10.1188/08.ONF.449-454
4024:Oncology Nursing Forum
4018:Elphee EE (May 2008).
2967:. lymphoma.about.com.
2944:Cite journal requires
2906:. Lymphoma.about.com.
2408:Aditya Bardia (2010).
2047:translational research
2029:
2018:
1984:
1641:Differential diagnosis
1558:
1541:(codes 9590–9999) and
1303:lymphoblastic lymphoma
1212:Lymphomatoid papulosis
1051:Plasmablastic lymphoma
755:
615:plasmablastic lymphoma
507:central nervous system
498:
448:
362:
354:
205:blood and lymph tumors
5603:Risky sexual behavior
5387:of medical conditions
4843:10.1089/jpm.2013.0014
4492:10.1056/NEJMoa1100340
3555:10.1093/annonc/mdi403
3431:10.1093/annonc/mdg414
2217:10.1093/annonc/mdt218
2016:
1920:
1747:platelet transfusions
1556:
1079:starry-sky appearance
752:
548:Non-Hodgkin lymphomas
543:Non-Hodgkin lymphomas
496:
438:
360:
352:
5664:Anatomical pathology
5593:Periodontal diseases
4921:10.1038/bmt.2008.436
4432:Kuruvilla J (2009).
4370:www.medpagetoday.com
4069:The Lancet. Oncology
3978:10.7759/cureus.45937
3680:Non-Hodgkin Lymphoma
3384:Lymphoma, Follicular
3294:10.7759/cureus.45937
3157:10.7759/cureus.45937
2337:(10053): 1459–1544.
2288:(10053): 1545–1602.
1831:Supportive treatment
1775:mantle cell lymphoma
1523:cell surface markers
1519:non-Hodgkin lymphoma
1399:cervical lymph nodes
947:Mantle cell lymphoma
839:Heavy chain diseases
293:. Blood, urine, and
244:non-Hodgkin lymphoma
221:enlarged lymph nodes
85:Enlarged lymph nodes
3902:10.1093/ajcp/aqy108
3505:Turgeon ML (2005).
3362:"Chronic Leukemias"
3326:Wagman LD. (2008).
2591:2017EPoll.231..319H
2254:. Seer.cancer.gov.
2071:Lymphoma in animals
1900:Unknown (unstaged)
1852:Stage at diagnosis
1645:Certain lymphomas (
1515:Working Formulation
1110:(NK) cell neoplasms
892:Follicular lymphoma
825:Plasma cell myeloma
814:Hairy cell leukemia
537:Reed–Sternberg cell
295:bone marrow testing
267:autoimmune diseases
117:autoimmune diseases
53:Follicular lymphoma
5559:Metabolic syndrome
5327:External resources
5081:"Hodgkin Lymphoma"
3542:Annals of Oncology
3418:Annals of Oncology
2377:Taylor EJ (2000).
2205:Annals of Oncology
2019:
1985:
1855:Five-year relative
1596:performance status
1589:fluorodeoxyglucose
1559:
1429:Epstein–Barr virus
756:
719:Burkitt's lymphoma
641:WHO classification
587:Epstein–Barr virus
499:
449:
363:
355:
345:Signs and symptoms
263:Epstein–Barr virus
207:that develop from
186:4.9 million (2015)
176:five year survival
113:Epstein–Barr virus
5674:Pediatric cancers
5646:
5645:
5633:Teenage pregnancy
5519:Domestic violence
5514:Diabetes mellitus
5350:
5349:
5224:on 5 January 2011
5141:Hodgkin's Disease
4397:(11): 1765–1772.
4192:(23): 1540–1545.
3940:(12): 1015–1020.
3819:(11): 1860–1861.
3774:(27): 3059–3068.
3740:www.icd10data.com
3624:978-0-7216-0040-6
3548:(12): 1928–1935.
3518:978-0-7817-5007-3
3424:(10): 1555–1561.
3343:978-1-891483-62-2
2823:978-1-4557-2865-7
2794:978-1-107-01059-8
2781:Marcus R (2013).
2767:978-92-832-0429-9
2585:(Pt 1): 319–328.
2421:978-1-4496-3141-3
1997:According to the
1910:
1909:
1367:Nodular sclerosis
1361:Hodgkin lymphomas
1297:15% of childhood
1156:Mycosis fungoides
865:differentiation,
731:hematopathologist
694:
693:
468:Immunophenotyping
461:histopathological
453:lymph-node biopsy
310:radiation therapy
291:lymph node biopsy
273:, infection with
235:, and constantly
198:
197:
151:radiation therapy
137:Lymph node biopsy
132:Diagnostic method
32:Medical condition
16:(Redirected from
5681:
5564:Mental disorders
5377:
5370:
5363:
5354:
5256:
5234:
5233:
5231:
5229:
5223:
5212:
5204:
5198:
5197:
5195:
5194:
5179:
5173:
5172:
5161:
5155:
5154:
5136:
5130:
5129:
5101:
5095:
5094:
5092:
5091:
5077:
5071:
5070:
5065:
5063:
5050:. Bethesda, MD:
5039:
5033:
5032:
5027:. Archived from
5021:
5015:
5014:
5004:
4972:
4966:
4965:
4963:
4962:
4947:
4941:
4940:
4904:
4898:
4897:
4878:10.1002/pon.3141
4872:(6): 1312–1318.
4861:
4855:
4854:
4837:(9): 1034–1039.
4825:
4819:
4818:
4782:
4776:
4775:
4773:
4772:
4757:
4751:
4750:
4732:
4708:
4699:
4698:
4697:
4695:
4690:on July 31, 2012
4689:
4683:, archived from
4671:
4658:
4652:
4651:
4641:
4617:
4611:
4610:
4600:
4568:
4562:
4561:
4551:
4519:
4513:
4512:
4494:
4470:
4464:
4463:
4453:
4429:
4423:
4422:
4386:
4380:
4379:
4377:
4376:
4361:
4355:
4354:
4344:
4327:(11): CD010983.
4312:
4306:
4305:
4295:
4267:
4261:
4260:
4250:
4218:
4212:
4211:
4201:
4177:
4171:
4170:
4147:Stain Technology
4142:
4136:
4135:
4099:
4093:
4092:
4064:
4058:
4057:
4039:
4015:
4009:
4008:
3998:
3980:
3956:
3950:
3949:
3929:
3923:
3922:
3904:
3876:
3870:
3869:
3859:
3835:
3829:
3828:
3808:
3802:
3801:
3791:
3759:
3750:
3749:
3747:
3746:
3732:
3726:
3725:
3715:
3707:
3705:
3704:
3693:
3687:
3676:
3670:
3669:
3659:
3635:
3629:
3628:
3610:
3604:
3603:
3574:
3568:
3567:
3557:
3533:
3527:
3526:
3502:
3496:
3487:
3469:
3443:
3433:
3400:
3391:
3380:
3374:
3373:
3358:
3352:
3351:
3323:
3317:
3316:
3306:
3296:
3272:
3266:
3265:
3242:Modern Pathology
3237:
3231:
3230:
3194:
3188:
3187:
3177:
3159:
3135:
3129:
3127:
3121:
3113:
3111:
3110:
3104:
3098:. Archived from
3097:
3088:
3082:
3080:
3078:
3077:
3061:
3055:
3054:
3052:
3050:
3039:
3033:
3032:
3004:
2998:
2994:
2981:
2980:
2978:
2976:
2960:
2954:
2953:
2947:
2942:
2940:
2932:
2925:
2919:
2918:
2916:
2915:
2900:
2879:
2878:
2876:
2874:
2863:"About Lymphoma"
2859:
2842:
2841:
2835:
2827:
2809:
2803:
2802:
2778:
2772:
2771:
2754:
2743:
2742:
2740:
2738:
2719:
2713:
2712:
2694:
2666:
2660:
2659:
2649:
2617:
2611:
2610:
2574:
2568:
2567:
2549:
2525:
2519:
2518:
2516:
2514:
2495:
2489:
2488:
2482:
2478:
2476:
2468:
2466:
2464:
2458:
2451:
2441:
2430:
2429:
2405:
2399:
2398:
2374:
2365:
2364:
2354:
2322:
2316:
2315:
2305:
2273:
2267:
2266:
2264:
2263:
2248:
2239:
2238:
2228:
2211:(9): 2245–2255.
2196:
2187:
2186:
2184:
2182:
2163:
2130:
2129:
2127:
2125:
2106:
2032:
1980:
1974:
1968:
1962:
1956:
1950:
1944:
1938:
1932:
1926:
1844:
1816:adverse events.
1781:Hodgkin lymphoma
1767:tisagenlecleucel
1714:Watchful waiting
1691:watchful waiting
1675:Burkitt lymphoma
1632:
1620:
1607:
1531:B-cell lymphomas
1527:T-cell lymphomas
1475:Associated with
1354:Hodgkin lymphoma
1329:mediastinal mass
1190:SĂ©zary's disease
1087:CD10, surface Ig
689:
686:
653:
645:
595:Burkitt lymphoma
523:Hodgkin lymphoma
517:Hodgkin lymphoma
445:light microscopy
398:Other symptoms:
339:developing world
326:Watchful waiting
318:targeted therapy
248:Hodgkin lymphoma
213:white blood cell
159:targeted therapy
47:
35:
21:
5689:
5688:
5684:
5683:
5682:
5680:
5679:
5678:
5649:
5648:
5647:
5642:
5388:
5381:
5351:
5346:
5345:
5322:
5321:
5267:
5242:
5237:
5227:
5225:
5221:
5210:
5206:
5205:
5201:
5192:
5190:
5181:
5180:
5176:
5163:
5162:
5158:
5151:
5138:
5137:
5133:
5103:
5102:
5098:
5089:
5087:
5079:
5078:
5074:
5061:
5059:
5041:
5040:
5036:
5023:
5022:
5018:
4987:(1): CD009075.
4974:
4973:
4969:
4960:
4958:
4949:
4948:
4944:
4906:
4905:
4901:
4866:Psycho-Oncology
4863:
4862:
4858:
4827:
4826:
4822:
4784:
4783:
4779:
4770:
4768:
4759:
4758:
4754:
4710:
4709:
4702:
4693:
4691:
4687:
4676:ABIM Foundation
4669:
4661:
4659:
4655:
4619:
4618:
4614:
4583:(7): CD012556.
4570:
4569:
4565:
4534:(8): CD012643.
4521:
4520:
4516:
4472:
4471:
4467:
4431:
4430:
4426:
4388:
4387:
4383:
4374:
4372:
4363:
4362:
4358:
4314:
4313:
4309:
4278:(5): CD004269.
4269:
4268:
4264:
4233:(1): CD009768.
4220:
4219:
4215:
4179:
4178:
4174:
4144:
4143:
4139:
4101:
4100:
4096:
4066:
4065:
4061:
4017:
4016:
4012:
3958:
3957:
3953:
3931:
3930:
3926:
3878:
3877:
3873:
3850:(14): 987–994.
3837:
3836:
3832:
3813:Cancer Research
3810:
3809:
3805:
3761:
3760:
3753:
3744:
3742:
3734:
3733:
3729:
3708:
3702:
3700:
3697:"Archived copy"
3695:
3694:
3690:
3677:
3673:
3637:
3636:
3632:
3625:
3615:Hematopathology
3612:
3611:
3607:
3576:
3575:
3571:
3535:
3534:
3530:
3519:
3504:
3503:
3499:
3447:
3411:
3401:
3394:
3381:
3377:
3360:
3359:
3355:
3344:
3325:
3324:
3320:
3274:
3273:
3269:
3239:
3238:
3234:
3199:Human Pathology
3196:
3195:
3191:
3137:
3136:
3132:
3114:
3108:
3106:
3102:
3095:
3093:"Archived copy"
3091:
3089:
3085:
3075:
3073:
3064:
3062:
3058:
3048:
3046:
3041:
3040:
3036:
3006:
3005:
3001:
2995:
2984:
2974:
2972:
2962:
2961:
2957:
2943:
2933:
2927:
2926:
2922:
2913:
2911:
2902:
2901:
2882:
2872:
2870:
2861:
2860:
2845:
2828:
2824:
2811:
2810:
2806:
2795:
2780:
2779:
2775:
2768:
2756:
2755:
2746:
2736:
2734:
2721:
2720:
2716:
2668:
2667:
2663:
2619:
2618:
2614:
2576:
2575:
2571:
2527:
2526:
2522:
2512:
2510:
2497:
2496:
2492:
2479:
2469:
2462:
2460:
2456:
2449:
2443:
2442:
2433:
2422:
2407:
2406:
2402:
2395:
2376:
2375:
2368:
2324:
2323:
2319:
2275:
2274:
2270:
2261:
2259:
2250:
2249:
2242:
2198:
2197:
2190:
2180:
2178:
2165:
2164:
2133:
2123:
2121:
2108:
2107:
2082:
2078:
2073:
2067:
2055:clinical trials
2043:
2011:
1983:
1982:
1978:
1976:
1972:
1970:
1966:
1964:
1960:
1958:
1954:
1952:
1948:
1946:
1942:
1940:
1936:
1934:
1930:
1928:
1924:
1915:
1861:
1856:
1842:
1833:
1825:Palliative care
1822:
1820:Palliative care
1783:
1726:
1699:lymphadenopathy
1683:
1667:
1643:
1636:
1633:
1624:
1621:
1612:
1608:
1551:
1508:
1503:
1502:
1501:
1488:corticosteroids
1472:Post-transplant
1458:
1454:
1453:
1440:Lymphocyte-rich
1355:
1351:
1350:
1274:
1270:
1269:
1183:5-year survival
1160:SĂ©zary syndrome
1111:
1099:
1098:
966:About 50 to 70%
930:overexpressing
746:
737:
690:
684:
681:
654:
643:
556:
545:
525:
519:
491:
433:
370:Lymphadenopathy
347:
335:developed world
299:Medical imaging
287:tobacco smoking
125:tobacco smoking
33:
28:
23:
22:
18:Lymphomagenesis
15:
12:
11:
5:
5687:
5685:
5677:
5676:
5671:
5666:
5661:
5651:
5650:
5644:
5643:
5641:
5640:
5635:
5630:
5625:
5620:
5615:
5610:
5605:
5600:
5595:
5590:
5589:
5588:
5578:
5573:
5572:
5571:
5561:
5556:
5551:
5546:
5541:
5536:
5531:
5526:
5521:
5516:
5511:
5506:
5505:
5504:
5494:
5489:
5488:
5487:
5482:
5477:
5472:
5467:
5462:
5457:
5452:
5447:
5442:
5437:
5427:
5422:
5420:Binge drinking
5417:
5412:
5407:
5402:
5396:
5394:
5390:
5389:
5382:
5380:
5379:
5372:
5365:
5357:
5348:
5347:
5344:
5343:
5331:
5330:
5328:
5324:
5323:
5320:
5319:
5308:
5300:
5288:
5268:
5263:
5262:
5260:
5259:Classification
5253:
5252:
5241:
5240:External links
5238:
5236:
5235:
5199:
5174:
5156:
5149:
5131:
5112:(5): 261–281.
5096:
5072:
5034:
5031:on 2013-10-10.
5016:
4967:
4942:
4915:(4): 265–273.
4899:
4856:
4820:
4777:
4752:
4723:(5): 423–435.
4717:Cancer Journal
4700:
4653:
4632:(6): 737–744.
4612:
4563:
4514:
4485:(3): 203–212.
4465:
4424:
4381:
4356:
4307:
4262:
4213:
4172:
4137:
4094:
4075:(4): 368–369.
4059:
4030:(3): 449–454.
4010:
3951:
3924:
3871:
3830:
3803:
3751:
3727:
3688:
3671:
3650:(1): 138–143.
3630:
3623:
3605:
3586:(2): 147–151.
3569:
3528:
3517:
3497:
3495:
3494:
3493:
3492:
3491:
3490:
3489:
3488:
3460:(4): 511–518.
3444:
3392:
3375:
3353:
3342:
3318:
3267:
3248:(12): 100330.
3232:
3189:
3130:
3083:
3056:
3034:
3015:(2): 127–134.
2999:
2982:
2955:
2946:|journal=
2920:
2880:
2843:
2822:
2804:
2793:
2773:
2766:
2744:
2714:
2677:(5): 595–606.
2661:
2612:
2569:
2540:(5): 937–951.
2520:
2505:. 2011-02-02.
2490:
2481:|website=
2431:
2420:
2400:
2393:
2366:
2317:
2268:
2240:
2188:
2173:. 2014-04-25.
2131:
2116:. 2014-04-23.
2079:
2077:
2074:
2069:Main article:
2066:
2063:
2051:basic research
2042:
2039:
2022:Thomas Hodgkin
2017:Thomas Hodgkin
2010:
2007:
1977:
1971:
1965:
1959:
1953:
1947:
1941:
1935:
1929:
1923:
1922:
1914:
1911:
1908:
1907:
1904:
1901:
1897:
1896:
1893:
1890:
1886:
1885:
1882:
1879:
1875:
1874:
1871:
1868:
1864:
1863:
1858:
1853:
1849:
1848:
1841:
1838:
1832:
1829:
1821:
1818:
1782:
1779:
1731:CHOP or R-CHOP
1725:
1722:
1682:
1679:
1666:
1663:
1642:
1639:
1638:
1637:
1634:
1627:
1625:
1622:
1615:
1613:
1609:
1602:
1550:
1547:
1507:
1504:
1500:
1499:
1480:
1473:
1470:
1463:
1459:
1456:
1455:
1452:
1451:
1446:
1445:
1444:
1441:
1435:
1434:
1433:
1432:
1425:
1422:
1419:
1413:
1412:
1411:
1410:
1404:
1403:
1402:
1401:
1391:
1382:
1379:
1373:
1372:
1371:
1370:
1356:
1353:
1352:
1349:
1348:
1347:
1346:
1325:
1312:
1306:
1292:
1291:
1286:
1281:
1275:
1272:
1271:
1268:
1267:
1262:
1248:
1242:
1241:
1240:
1239:
1236:
1231:
1228:
1222:
1221:
1216:
1215:
1214:
1209:
1200:
1199:
1198:
1197:
1186:
1180:
1175:
1169:
1163:
1162:
1153:
1148:
1143:
1138:
1133:
1128:
1123:
1118:
1112:
1108:natural killer
1101:
1100:
1097:
1096:
1095:
1094:
1091:
1088:
1085:
1075:
1069:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1017:
1016:
1015:
1014:
1011:
1005:
1004:and surface Ig
998:
995:
989:
988:
981:
980:
979:
978:
967:
964:
959:
956:
950:
949:
944:
938:
937:
936:
935:
924:
921:
912:
901:
895:
894:
889:
883:
882:
881:
880:
877:
870:
859:
853:
852:
848:, also called
843:
842:
841:
836:
833:
828:
816:
811:
806:
796:
790:
789:
788:
787:
784:
781:
779:immunoglobulin
775:
769:
763:
762:
747:
740:
739:
738:
735:
692:
691:
668:screen readers
657:
655:
648:
642:
639:
567:lymphoid cells
555:
552:
544:
541:
521:Main article:
518:
515:
490:
489:Classification
487:
486:
485:
475:
473:Flow cytometry
470:
432:
429:
428:
427:
426:
425:
420:
415:
410:
405:
396:
395:
394:
389:
384:
373:
346:
343:
322:plasmapheresis
314:proton therapy
203:is a group of
196:
195:
194:204,700 (2015)
192:
188:
187:
184:
180:
179:
172:
166:
165:
155:proton therapy
144:
140:
139:
134:
128:
127:
110:
104:
103:
82:
76:
75:
66:
60:
59:
49:
48:
40:
39:
31:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5686:
5675:
5672:
5670:
5667:
5665:
5662:
5660:
5657:
5656:
5654:
5639:
5636:
5634:
5631:
5629:
5626:
5624:
5621:
5619:
5616:
5614:
5611:
5609:
5608:Schizophrenia
5606:
5604:
5601:
5599:
5596:
5594:
5591:
5587:
5584:
5583:
5582:
5579:
5577:
5574:
5570:
5567:
5566:
5565:
5562:
5560:
5557:
5555:
5552:
5550:
5547:
5545:
5542:
5540:
5537:
5535:
5532:
5530:
5527:
5525:
5522:
5520:
5517:
5515:
5512:
5510:
5507:
5503:
5500:
5499:
5498:
5495:
5493:
5490:
5486:
5483:
5481:
5478:
5476:
5473:
5471:
5468:
5466:
5463:
5461:
5458:
5456:
5453:
5451:
5448:
5446:
5443:
5441:
5438:
5436:
5433:
5432:
5431:
5428:
5426:
5423:
5421:
5418:
5416:
5413:
5411:
5408:
5406:
5403:
5401:
5398:
5397:
5395:
5391:
5386:
5378:
5373:
5371:
5366:
5364:
5359:
5358:
5355:
5342:
5338:
5337:
5333:
5332:
5329:
5325:
5318:
5314:
5313:
5309:
5306:
5305:
5301:
5298:
5297:
5293:
5289:
5287:
5283:
5279:
5278:
5274:
5270:
5269:
5266:
5261:
5257:
5251:
5247:
5244:
5243:
5239:
5220:
5216:
5209:
5203:
5200:
5188:
5184:
5178:
5175:
5170:
5166:
5160:
5157:
5152:
5150:0-7817-1502-4
5146:
5142:
5135:
5132:
5127:
5123:
5119:
5115:
5111:
5107:
5106:Blood Reviews
5100:
5097:
5086:
5082:
5076:
5073:
5069:
5057:
5053:
5049:
5045:
5038:
5035:
5030:
5026:
5020:
5017:
5012:
5008:
5003:
4998:
4994:
4990:
4986:
4982:
4978:
4971:
4968:
4956:
4952:
4946:
4943:
4938:
4934:
4930:
4926:
4922:
4918:
4914:
4910:
4903:
4900:
4895:
4891:
4887:
4883:
4879:
4875:
4871:
4867:
4860:
4857:
4852:
4848:
4844:
4840:
4836:
4832:
4824:
4821:
4816:
4812:
4808:
4804:
4800:
4796:
4792:
4788:
4781:
4778:
4766:
4762:
4756:
4753:
4748:
4744:
4740:
4736:
4731:
4726:
4722:
4718:
4714:
4707:
4705:
4701:
4686:
4682:
4678:
4677:
4668:
4664:
4657:
4654:
4649:
4645:
4640:
4635:
4631:
4627:
4623:
4616:
4613:
4608:
4604:
4599:
4594:
4590:
4586:
4582:
4578:
4574:
4567:
4564:
4559:
4555:
4550:
4545:
4541:
4537:
4533:
4529:
4525:
4518:
4515:
4510:
4506:
4502:
4498:
4493:
4488:
4484:
4480:
4476:
4469:
4466:
4461:
4457:
4452:
4447:
4443:
4439:
4435:
4428:
4425:
4420:
4416:
4412:
4408:
4404:
4400:
4396:
4392:
4385:
4382:
4371:
4367:
4360:
4357:
4352:
4348:
4343:
4338:
4334:
4330:
4326:
4322:
4318:
4311:
4308:
4303:
4299:
4294:
4289:
4285:
4281:
4277:
4273:
4266:
4263:
4258:
4254:
4249:
4244:
4240:
4236:
4232:
4228:
4224:
4217:
4214:
4209:
4205:
4200:
4195:
4191:
4187:
4183:
4176:
4173:
4168:
4164:
4160:
4156:
4152:
4148:
4141:
4138:
4133:
4129:
4125:
4121:
4117:
4113:
4109:
4105:
4098:
4095:
4090:
4086:
4082:
4078:
4074:
4070:
4063:
4060:
4055:
4051:
4047:
4043:
4038:
4033:
4029:
4025:
4021:
4014:
4011:
4006:
4002:
3997:
3992:
3988:
3984:
3979:
3974:
3971:(9): e45937.
3970:
3966:
3962:
3955:
3952:
3947:
3943:
3939:
3935:
3928:
3925:
3920:
3916:
3912:
3908:
3903:
3898:
3894:
3890:
3886:
3882:
3875:
3872:
3867:
3863:
3858:
3853:
3849:
3845:
3841:
3834:
3831:
3826:
3822:
3818:
3814:
3807:
3804:
3799:
3795:
3790:
3785:
3781:
3777:
3773:
3769:
3765:
3758:
3756:
3752:
3741:
3737:
3731:
3728:
3723:
3719:
3713:
3698:
3692:
3689:
3686:
3682:
3681:
3675:
3672:
3667:
3663:
3658:
3653:
3649:
3645:
3641:
3634:
3631:
3626:
3620:
3616:
3609:
3606:
3601:
3597:
3593:
3589:
3585:
3581:
3573:
3570:
3565:
3561:
3556:
3551:
3547:
3543:
3539:
3532:
3529:
3524:
3520:
3514:
3510:
3509:
3501:
3498:
3485:
3481:
3477:
3473:
3468:
3463:
3459:
3455:
3451:
3445:
3441:
3437:
3432:
3427:
3423:
3419:
3415:
3409:
3408:
3407:
3406:
3405:
3404:
3403:
3402:
3399:
3397:
3393:
3390:
3386:
3385:
3379:
3376:
3371:
3367:
3363:
3357:
3354:
3349:
3345:
3339:
3335:
3334:
3329:
3322:
3319:
3314:
3310:
3305:
3300:
3295:
3290:
3287:(9): e45937.
3286:
3282:
3278:
3271:
3268:
3263:
3259:
3255:
3251:
3247:
3243:
3236:
3233:
3228:
3224:
3220:
3216:
3212:
3208:
3204:
3200:
3193:
3190:
3185:
3181:
3176:
3171:
3167:
3163:
3158:
3153:
3150:(9): e45937.
3149:
3145:
3141:
3134:
3131:
3125:
3119:
3105:on 2014-01-24
3101:
3094:
3087:
3084:
3071:
3067:
3060:
3057:
3044:
3038:
3035:
3030:
3026:
3022:
3018:
3014:
3010:
3003:
3000:
2993:
2991:
2989:
2987:
2983:
2970:
2966:
2959:
2956:
2951:
2938:
2931:. 2019-11-09.
2930:
2924:
2921:
2909:
2905:
2899:
2897:
2895:
2893:
2891:
2889:
2887:
2885:
2881:
2868:
2864:
2858:
2856:
2854:
2852:
2850:
2848:
2844:
2839:
2833:
2825:
2819:
2815:
2808:
2805:
2800:
2796:
2790:
2786:
2785:
2777:
2774:
2769:
2763:
2759:
2753:
2751:
2749:
2745:
2732:
2728:
2724:
2718:
2715:
2710:
2706:
2702:
2698:
2693:
2688:
2684:
2680:
2676:
2672:
2665:
2662:
2657:
2653:
2648:
2643:
2639:
2635:
2632:(45): e1729.
2631:
2627:
2623:
2616:
2613:
2608:
2604:
2600:
2596:
2592:
2588:
2584:
2580:
2573:
2570:
2565:
2561:
2557:
2553:
2548:
2543:
2539:
2535:
2531:
2524:
2521:
2508:
2504:
2500:
2494:
2491:
2486:
2474:
2455:
2448:
2447:
2440:
2438:
2436:
2432:
2427:
2423:
2417:
2413:
2412:
2404:
2401:
2396:
2394:0-7216-6254-4
2390:
2386:
2382:
2381:
2373:
2371:
2367:
2362:
2358:
2353:
2348:
2344:
2340:
2336:
2332:
2328:
2321:
2318:
2313:
2309:
2304:
2299:
2295:
2291:
2287:
2283:
2279:
2272:
2269:
2257:
2253:
2247:
2245:
2241:
2236:
2232:
2227:
2222:
2218:
2214:
2210:
2206:
2202:
2195:
2193:
2189:
2176:
2172:
2168:
2162:
2160:
2158:
2156:
2154:
2152:
2150:
2148:
2146:
2144:
2142:
2140:
2138:
2136:
2132:
2119:
2115:
2111:
2105:
2103:
2101:
2099:
2097:
2095:
2093:
2091:
2089:
2087:
2085:
2081:
2075:
2072:
2065:Other animals
2064:
2062:
2058:
2056:
2052:
2048:
2040:
2038:
2036:
2031:
2025:
2023:
2015:
2008:
2006:
2002:
2000:
1995:
1992:
1990:
1981: 122–184
1919:
1912:
1898:
1887:
1876:
1865:
1862:of cases (%)
1857:survival (%)
1850:
1845:
1839:
1837:
1830:
1828:
1826:
1819:
1817:
1814:
1809:
1806:
1801:
1799:
1795:
1791:
1786:
1780:
1778:
1776:
1772:
1768:
1764:
1760:
1756:
1751:
1748:
1744:
1740:
1735:
1732:
1723:
1721:
1719:
1715:
1711:
1706:
1704:
1700:
1694:
1692:
1688:
1680:
1678:
1676:
1672:
1664:
1662:
1660:
1656:
1652:
1648:
1640:
1631:
1626:
1619:
1614:
1606:
1601:
1599:
1597:
1594:Age and poor
1592:
1590:
1586:
1582:
1578:
1576:
1571:
1566:
1564:
1555:
1548:
1546:
1544:
1540:
1534:
1532:
1528:
1524:
1520:
1516:
1511:
1505:
1497:
1493:
1489:
1484:
1481:
1478:
1474:
1471:
1468:
1464:
1461:
1460:
1450:
1447:
1442:
1439:
1438:
1437:
1436:
1430:
1426:
1423:
1420:
1417:
1416:
1415:
1414:
1408:
1407:
1406:
1405:
1400:
1396:
1392:
1390:
1386:
1383:
1380:
1377:
1376:
1375:
1374:
1368:
1365:
1364:
1362:
1358:
1357:
1344:
1340:
1339:
1334:
1330:
1326:
1324:
1320:
1316:
1313:
1310:
1307:
1304:
1300:
1296:
1295:
1294:
1293:
1290:
1287:
1285:
1282:
1280:
1277:
1276:
1266:
1263:
1260:
1256:
1252:
1249:
1247:
1244:
1243:
1237:
1235:
1232:
1229:
1226:
1225:
1224:
1223:
1220:
1217:
1213:
1210:
1208:
1205:
1204:
1202:
1201:
1195:
1191:
1187:
1184:
1181:
1179:
1176:
1174:
1170:
1167:
1166:
1165:
1164:
1161:
1157:
1154:
1152:
1149:
1147:
1144:
1142:
1139:
1137:
1134:
1132:
1129:
1127:
1124:
1122:
1119:
1117:
1114:
1113:
1109:
1105:
1092:
1089:
1086:
1084:
1080:
1076:
1073:
1072:
1071:
1070:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1024:
1022:
1019:
1018:
1012:
1009:
1006:
1003:
999:
996:
993:
992:
991:
990:
986:
983:
982:
976:
972:
968:
965:
963:
960:
957:
954:
953:
952:
951:
948:
945:
943:
940:
939:
933:
929:
928:translocation
925:
922:
920:
916:
913:
910:
906:
902:
899:
898:
897:
896:
893:
890:
888:
885:
884:
878:
875:
871:
868:
864:
860:
857:
856:
855:
854:
851:
850:MALT lymphoma
847:
844:
840:
837:
834:
832:
829:
826:
823:
822:
820:
817:
815:
812:
810:
807:
804:
800:
797:
795:
792:
791:
785:
782:
780:
777:CD5, surface
776:
774:
770:
767:
766:
765:
764:
761:
758:
757:
751:
744:
734:
732:
728:
724:
720:
716:
711:
708:
704:
700:
688:
679:
675:
673:
669:
664:
662:
661:accessibility
656:
652:
647:
646:
640:
638:
636:
632:
628:
624:
620:
616:
612:
608:
604:
600:
596:
592:
588:
584:
580:
576:
572:
568:
564:
560:
553:
551:
549:
542:
540:
538:
534:
530:
524:
516:
514:
512:
508:
503:
495:
488:
483:
482:hybridization
481:
478:Fluorescence
476:
474:
471:
469:
466:
465:
464:
462:
458:
454:
446:
442:
441:H&E stain
437:
430:
424:
421:
419:
416:
414:
411:
409:
406:
403:
400:
399:
397:
393:
390:
388:
385:
383:
380:
379:
377:
374:
371:
368:
367:
366:
359:
351:
344:
342:
340:
336:
331:
327:
323:
319:
315:
311:
307:
302:
300:
296:
292:
288:
284:
280:
276:
272:
268:
264:
259:
257:
253:
249:
245:
240:
238:
237:feeling tired
234:
230:
226:
222:
218:
214:
210:
206:
202:
193:
189:
185:
181:
177:
173:
171:
167:
164:
160:
156:
152:
148:
145:
141:
138:
135:
133:
129:
126:
122:
118:
114:
111:
109:
105:
102:
101:feeling tired
98:
94:
90:
86:
83:
81:
77:
74:
70:
67:
65:
61:
58:
54:
50:
46:
41:
36:
30:
19:
5638:Tuberculosis
5549:Malnutrition
5393:Health topic
5385:epidemiology
5334:
5310:
5302:
5290:
5271:
5226:. Retrieved
5219:the original
5214:
5202:
5191:. Retrieved
5177:
5168:
5159:
5140:
5134:
5109:
5105:
5099:
5088:. Retrieved
5084:
5075:
5067:
5060:. Retrieved
5047:
5037:
5029:the original
5019:
4984:
4980:
4970:
4959:. Retrieved
4945:
4912:
4908:
4902:
4869:
4865:
4859:
4834:
4830:
4823:
4793:(2): 71–75.
4790:
4786:
4780:
4769:. Retrieved
4755:
4720:
4716:
4692:, retrieved
4685:the original
4673:
4656:
4629:
4625:
4615:
4580:
4576:
4566:
4531:
4527:
4517:
4482:
4478:
4468:
4441:
4437:
4427:
4394:
4390:
4384:
4373:. Retrieved
4369:
4359:
4324:
4320:
4310:
4275:
4265:
4230:
4226:
4216:
4189:
4185:
4175:
4153:(1): 23–26.
4150:
4146:
4140:
4107:
4103:
4097:
4072:
4068:
4062:
4027:
4023:
4013:
3968:
3964:
3954:
3937:
3933:
3927:
3895:(1): 75–85.
3892:
3888:
3874:
3847:
3843:
3833:
3816:
3812:
3806:
3771:
3767:
3743:. Retrieved
3739:
3730:
3701:. Retrieved
3691:
3678:
3674:
3647:
3643:
3633:
3614:
3608:
3583:
3579:
3572:
3545:
3541:
3531:
3507:
3500:
3457:
3453:
3421:
3417:
3382:
3378:
3365:
3356:
3332:
3321:
3284:
3280:
3270:
3245:
3241:
3235:
3202:
3198:
3192:
3147:
3143:
3133:
3107:. Retrieved
3100:the original
3086:
3074:. Retrieved
3059:
3047:. Retrieved
3045:. 2015-05-14
3037:
3012:
3008:
3002:
2973:. Retrieved
2958:
2937:cite journal
2923:
2912:. Retrieved
2871:. Retrieved
2813:
2807:
2783:
2776:
2757:
2735:. Retrieved
2726:
2717:
2692:11573/865541
2674:
2670:
2664:
2629:
2625:
2615:
2582:
2578:
2572:
2537:
2533:
2523:
2511:. Retrieved
2502:
2493:
2461:. Retrieved
2445:
2410:
2403:
2379:
2334:
2330:
2320:
2285:
2281:
2271:
2260:. Retrieved
2208:
2204:
2179:. Retrieved
2170:
2122:. Retrieved
2113:
2059:
2044:
2034:
2026:
2020:
2003:
1996:
1993:
1986:
1975: 89–121
1913:Epidemiology
1834:
1823:
1810:
1802:
1787:
1784:
1752:
1736:
1727:
1707:
1695:
1684:
1668:
1644:
1593:
1579:
1567:
1560:
1535:
1512:
1509:
1496:chemotherapy
1492:radiotherapy
1477:methotrexate
1336:
1309:Lymphoblasts
1259:ALK-negative
1255:ALK-positive
923:About 72–77%
909:centroblasts
876:, surface Ig
831:Plasmacytoma
712:
695:
682:
666:
658:
563:premalignant
557:
546:
533:pathological
531:and several
526:
504:
500:
479:
450:
387:Night sweats
364:
306:chemotherapy
303:
260:
241:
227:, drenching
200:
199:
147:Chemotherapy
108:Risk factors
55:replacing a
29:
5529:Hepatitis D
5524:Hepatitis C
5492:Chikungunya
5336:MedlinePlus
5307:: 9590–9999
4444:: 497–506.
4110:: 532–541.
2997:Manuscript.
2975:22 December
2963:Mallick I.
2873:22 December
1969: 58–88
1963: 43–57
1957: 35–42
1951: 29–34
1945: 23–28
1939: 19–22
1933: 14–18
1395:mediastinum
1301:and 90% of
905:centrocytes
863:plasma cell
821:neoplasms:
819:Plasma cell
729:(usually a
727:pathologist
707:cytogenetic
392:Weight loss
281:, and some
211:(a type of
209:lymphocytes
5669:Hematology
5653:Categories
5613:Snakebites
5509:Depression
5455:esophageal
5450:colorectal
5193:2012-10-30
5090:2024-04-22
5062:3 November
4961:2014-08-21
4771:2014-08-21
4694:August 14,
4375:2021-02-09
3745:2022-02-02
3703:2005-11-07
3109:2013-08-05
3076:2013-08-05
2914:2012-12-01
2499:"Lymphoma"
2262:2012-08-26
2076:References
1927: 0–13
1860:Percentage
1798:Stanford V
1724:High-grade
1424:CD15, CD30
1359:Classical
1343:adolescent
934:, indolent
917:, surface
699:phenotypic
457:lymph node
376:B symptoms
283:pesticides
69:Hematology
57:lymph node
5598:Pneumonia
5586:childhood
3987:2168-8184
3881:Pinkus GS
3685:eMedicine
3389:eMedicine
3205:: 18–41.
3166:2168-8184
3049:2 October
2832:cite book
2483:ignored (
2473:cite book
1840:Prognosis
1813:Nivolumab
1710:rituximab
1703:incurable
1681:Low-grade
1665:Treatment
1575:diaphragm
1083:apoptosis
975:cyclin D1
801:(such as
745:neoplasms
723:prognosis
703:molecular
685:July 2024
678:talk page
529:prognosis
431:Diagnosis
337:than the
252:leukemias
217:cancerous
183:Frequency
178:85% (USA)
170:Prognosis
143:Treatment
64:Specialty
5659:Lymphoma
5628:Syphilis
5539:HIV/AIDS
5497:Dementia
5470:prostate
5465:lymphoma
5445:cervical
5415:Bed bugs
5246:Lymphoma
5187:Archived
5126:18456377
5056:Archived
5011:30702150
4955:Archived
4937:20112284
4929:19151797
4894:31552330
4886:22836818
4851:23901834
4807:20078405
4765:Archived
4747:39881122
4739:20890138
4648:17531914
4607:30001476
4558:31930780
4509:10038896
4501:21774708
4460:20008235
4419:11004437
4411:19883306
4351:26576687
4302:22592695
4257:30697701
4132:12185761
4124:20008238
4089:24602759
4054:25207677
4046:18467294
4005:37900448
3996:10601349
3946:20017283
3934:Oncology
3919:52272766
3911:30212873
3798:25113753
3712:cite web
3666:14744745
3600:10435806
3564:16284057
3523:Archived
3484:32350562
3476:19075279
3440:14504058
3370:Archived
3348:Archived
3313:37900448
3304:10601349
3262:37716508
3227:47010934
3219:29885408
3184:37900448
3175:10601349
3128:), pg 4.
3118:cite web
3070:Archived
3029:20696592
2969:Archived
2908:Archived
2867:Archived
2799:Archived
2731:Archived
2709:17430078
2701:27076059
2656:26559248
2626:Medicine
2607:28810201
2556:19357394
2507:Archived
2454:Archived
2452:. 2013.
2426:Archived
2361:27733281
2312:27733282
2256:Archived
2235:23788758
2175:Archived
2118:Archived
2041:Research
1687:indolent
1611:H&E)
1585:PET scan
1194:erythema
971:GI tract
579:NK cells
511:meninges
271:HIV/AIDS
201:Lymphoma
174:Average
121:HIV/AIDS
80:Symptoms
73:oncology
38:Lymphoma
5618:Suicide
5581:Obesity
5554:Measles
5544:Leprosy
5485:ovarian
5480:stomach
5435:bladder
5383:Global
5317:D008223
5299:: 202.8
5002:6354325
4815:8355159
4598:6513229
4549:6984446
4342:4717525
4293:4338578
4248:6353308
4208:7477169
4167:4550425
3866:8141877
3825:5121694
3789:4979083
2737:18 June
2647:4912242
2587:Bibcode
2564:3101472
2513:13 June
2463:20 June
2352:5388903
2303:5055577
2226:3755332
2181:20 June
2124:20 June
2009:History
1794:BEACOPP
1718:anxiety
1581:CT scan
1549:Staging
1479:therapy
1192:, skin
1102:Mature
773:effaced
741:Mature
575:T cells
571:B cells
569:(i.e.,
484:testing
480:in situ
423:Itching
413:Fatigue
233:itching
163:surgery
97:itching
5623:Stroke
5534:Herpes
5440:breast
5430:Cancer
5410:Autism
5400:Asthma
5341:000580
5250:Curlie
5228:19 May
5165:"-oma"
5147:
5124:
5009:
4999:
4935:
4927:
4892:
4884:
4849:
4813:
4805:
4745:
4737:
4646:
4605:
4595:
4556:
4546:
4507:
4499:
4458:
4417:
4409:
4349:
4339:
4300:
4290:
4255:
4245:
4206:
4165:
4130:
4122:
4087:
4052:
4044:
4003:
3993:
3985:
3965:Cureus
3944:
3917:
3909:
3864:
3823:
3796:
3786:
3664:
3621:
3598:
3562:
3515:
3482:
3474:
3438:
3340:
3311:
3301:
3281:Cureus
3260:
3225:
3217:
3182:
3172:
3164:
3144:Cureus
3027:
2820:
2791:
2764:
2707:
2699:
2654:
2644:
2605:
2562:
2554:
2418:
2391:
2359:
2349:
2331:Lancet
2310:
2300:
2282:Lancet
2233:
2223:
2030:lympha
1979:
1973:
1967:
1961:
1955:
1949:
1943:
1937:
1931:
1925:
1563:staged
1543:ICD-10
1494:, and
1345:males.
1338:NOTCH1
1333:thymus
1104:T cell
867:homing
743:B cell
672:hidden
633:; and
581:, and
402:Anemia
229:sweats
191:Deaths
93:sweats
5569:child
5460:liver
5304:ICD-O
5222:(PDF)
5211:(PDF)
4933:S2CID
4890:S2CID
4811:S2CID
4743:S2CID
4688:(PDF)
4670:(PDF)
4505:S2CID
4415:S2CID
4128:S2CID
4050:S2CID
3915:S2CID
3480:S2CID
3223:S2CID
3103:(PDF)
3096:(PDF)
2705:S2CID
2560:S2CID
2534:Blood
2457:(PDF)
2450:(PDF)
1903:68.6
1892:62.7
1881:78.3
1870:82.3
1773:(for
1753:Four
1671:grade
1539:ICD-O
1261:types
932:Bcl-2
872:CD5,
705:, or
382:Fever
225:fever
89:fever
5475:skin
5312:MeSH
5296:9-CM
5230:2010
5145:ISBN
5122:PMID
5064:2009
5007:PMID
4925:PMID
4882:PMID
4847:PMID
4803:PMID
4735:PMID
4696:2012
4644:PMID
4603:PMID
4581:2018
4554:PMID
4497:PMID
4456:PMID
4442:2009
4407:PMID
4347:PMID
4325:2015
4298:PMID
4253:PMID
4204:PMID
4163:PMID
4120:PMID
4108:2009
4085:PMID
4042:PMID
4001:PMID
3983:ISSN
3942:PMID
3907:PMID
3862:PMID
3821:PMID
3794:PMID
3722:link
3718:link
3662:PMID
3619:ISBN
3596:PMID
3560:PMID
3513:ISBN
3472:PMID
3436:PMID
3338:ISBN
3309:PMID
3258:PMID
3215:PMID
3180:PMID
3162:ISSN
3124:link
3051:2017
3025:PMID
2977:2012
2950:help
2875:2012
2838:link
2818:ISBN
2789:ISBN
2762:ISBN
2739:2014
2697:PMID
2652:PMID
2603:PMID
2552:PMID
2515:2014
2485:help
2465:2014
2416:ISBN
2389:ISBN
2385:1038
2357:PMID
2308:PMID
2231:PMID
2183:2014
2126:2014
2049:and
2035:-oma
1796:and
1790:ABVD
1649:and
1573:the
1568:The
1529:and
1513:The
1389:CD30
1385:CD15
1257:and
1106:and
1002:CD10
915:CD10
874:CD10
659:The
71:and
5292:ICD
5286:C96
5282:C81
5273:ICD
5248:at
5114:doi
4997:PMC
4989:doi
4917:doi
4874:doi
4839:doi
4795:doi
4791:192
4725:doi
4634:doi
4593:PMC
4585:doi
4544:PMC
4536:doi
4487:doi
4483:365
4446:doi
4399:doi
4337:PMC
4329:doi
4288:PMC
4280:doi
4243:PMC
4235:doi
4194:doi
4190:333
4155:doi
4112:doi
4077:doi
4032:doi
3991:PMC
3973:doi
3897:doi
3893:151
3852:doi
3848:329
3784:PMC
3776:doi
3683:at
3652:doi
3588:doi
3550:doi
3462:doi
3426:doi
3387:at
3299:PMC
3289:doi
3250:doi
3207:doi
3170:PMC
3152:doi
3017:doi
2727:NCI
2687:hdl
2679:doi
2642:PMC
2634:doi
2595:doi
2583:231
2542:doi
2538:114
2503:NCI
2347:PMC
2339:doi
2335:388
2298:PMC
2290:doi
2286:388
2221:PMC
2213:doi
1895:47
1884:19
1873:26
1583:or
1467:HIV
1397:or
1323:CD7
1319:CD2
1315:TdT
1234:CD3
1185:75%
1178:CD4
1010:60%
962:CD5
733:).
680:.
5655::
5339::
5315::
5280::
5277:10
5213:.
5185:.
5167:.
5120:.
5110:22
5108:.
5083:.
5066:.
5054:.
5046:.
5005:.
4995:.
4983:.
4979:.
4953:.
4931:.
4923:.
4913:43
4911:.
4888:.
4880:.
4870:22
4868:.
4845:.
4835:16
4833:.
4809:.
4801:.
4789:.
4763:.
4741:.
4733:.
4721:16
4719:.
4715:.
4703:^
4679:,
4672:,
4665:,
4642:.
4630:33
4628:.
4624:.
4601:.
4591:.
4579:.
4575:.
4552:.
4542:.
4530:.
4526:.
4503:.
4495:.
4481:.
4477:.
4454:.
4440:.
4436:.
4413:.
4405:.
4395:50
4393:.
4368:.
4345:.
4335:.
4323:.
4319:.
4296:.
4286:.
4274:.
4251:.
4241:.
4229:.
4225:.
4202:.
4188:.
4184:.
4161:.
4151:47
4149:.
4126:.
4118:.
4106:.
4083:.
4073:15
4071:.
4048:.
4040:.
4028:35
4026:.
4022:.
3999:.
3989:.
3981:.
3969:15
3967:.
3963:.
3938:23
3936:.
3913:.
3905:.
3891:.
3887:.
3860:.
3846:.
3842:.
3817:31
3815:.
3792:.
3782:.
3772:32
3770:.
3766:.
3754:^
3738:.
3714:}}
3710:{{
3660:.
3648:13
3646:.
3642:.
3594:.
3584:51
3582:.
3558:.
3546:16
3544:.
3540:.
3521:.
3478:.
3470:.
3458:27
3456:.
3452:.
3434:.
3422:14
3420:.
3416:.
3395:^
3368:.
3364:.
3346:.
3307:.
3297:.
3285:15
3283:.
3279:.
3256:.
3246:36
3244:.
3221:.
3213:.
3203:79
3201:.
3178:.
3168:.
3160:.
3148:15
3146:.
3142:.
3120:}}
3116:{{
3068:.
3023:.
3013:79
3011:.
2985:^
2941::
2939:}}
2935:{{
2883:^
2846:^
2834:}}
2830:{{
2797:.
2747:^
2729:.
2725:.
2703:.
2695:.
2685:.
2675:27
2673:.
2650:.
2640:.
2630:94
2628:.
2624:.
2601:.
2593:.
2581:.
2558:.
2550:.
2536:.
2532:.
2501:.
2477::
2475:}}
2471:{{
2434:^
2424:.
2387:.
2369:^
2355:.
2345:.
2333:.
2329:.
2306:.
2296:.
2284:.
2280:.
2243:^
2229:.
2219:.
2209:24
2207:.
2203:.
2191:^
2169:.
2134:^
2112:.
2083:^
1906:8
1765:,
1705:.
1490:,
1387:,
1363::
1321:,
1317:,
1253::
919:Ig
701:,
637:.
629:;
625:;
621:;
617:;
613:;
609:;
605:;
601:;
597:;
577:,
573:,
539:.
341:.
316:,
312:,
308:,
277:,
269:,
258:.
223:,
161:,
157:,
153:,
149:,
123:,
119:,
115:,
99:,
91:,
87:,
5376:e
5369:t
5362:v
5294:-
5284:–
5275:-
5265:D
5232:.
5196:.
5171:.
5153:.
5128:.
5116::
5093:.
5013:.
4991::
4985:1
4964:.
4939:.
4919::
4896:.
4876::
4853:.
4841::
4817:.
4797::
4774:.
4749:.
4727::
4650:.
4636::
4609:.
4587::
4560:.
4538::
4532:1
4511:.
4489::
4462:.
4448::
4421:.
4401::
4378:.
4353:.
4331::
4304:.
4282::
4259:.
4237::
4231:1
4210:.
4196::
4169:.
4157::
4134:.
4114::
4091:.
4079::
4056:.
4034::
4007:.
3975::
3948:.
3921:.
3899::
3868:.
3854::
3827:.
3800:.
3778::
3748:.
3724:)
3706:.
3668:.
3654::
3627:.
3602:.
3590::
3566:.
3552::
3486:.
3464::
3442:.
3428::
3315:.
3291::
3264:.
3252::
3229:.
3209::
3186:.
3154::
3126:)
3112:.
3079:.
3053:.
3031:.
3019::
2979:.
2952:)
2948:(
2917:.
2877:.
2840:)
2826:.
2770:.
2741:.
2711:.
2689::
2681::
2658:.
2636::
2609:.
2597::
2589::
2566:.
2544::
2517:.
2487:)
2467:.
2397:.
2363:.
2341::
2314:.
2292::
2265:.
2237:.
2215::
2185:.
2128:.
1469:)
1305:.
1158:/
805:)
687:)
683:(
674:.
447:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
