Knowledge (XXG)

LARP1

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LARP1 is the largest of a 7-member family of LARP proteins (others are: LARP1B, LARP3 (aka genuine La or SSB), LARP4A, LARP4B, LARP6 and LARP7). All LARP proteins, including human LARPs, contain 2 conserved regions. The first conserved region shares homology with La proteins (called the La motif, see
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Several studies have demonstrated that LARP1 deficiency selectively affects the recruitment of TOP mRNAs to polysomes. In some cancer cells, LARP1 deficiency reduces proliferation and activates apoptotic cell death. Even though a decrease abundance of proteins encoded by TOP mRNAs has been reported
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interactions. Human LARP1 is present at low levels in normal, non-embryonic cells but is highly expressed in epithelial cancers (such as ovarian, colorectal, prostate, non-small cell lung, hepatocellular and cervical cancers). Some studies have shown that high levels of LARP1 protein correlate with
52: 1216:) whereas the second conserved region (called the LA- motif) is restricted to LARP proteins. LARP1 and 1B also contain a conserved "DM15 region" within their C-terminus. This region is unique and has been shown to be required for RNA-binding. Mouse Larp1 is expressed in 1203:. LARP1 is a novel target of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, a circuitry often hyperactivated in cancer which regulates cell growth and proliferation primarily through the regulation of protein synthesis. 2199:
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization".
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in LARP1 silenced cells, some researchers believe that this can be explained simply by the reduced number of TOP mRNA transcripts in LARP1-deficient cells.
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of mRNAs. It has also been shown to interact with the 3' end and coding regions (CDS) of other genes. LARP1 protein colocalizes with
1137: 279: 1444: 1257: 1421: 1404: 1310: 1289: 1306: 2062:"Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA" 1810:"Overexpression of LARP1 predicts poor prognosis of colorectal cancer and is expected to be a potential therapeutic target" 201: 176: 2008:"C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis" 1213: 1285: 118: 315: 214: 1710:"The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer" 308: 207: 2327: 109:, LARP, La ribonucleoprotein domain family member 1, La ribonucleoprotein 1, translational regulator, Lar1, Lhp1 1460:"Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation" 911: 126: 1260:
mRNAs. The cluster of LARP1 homologs may function to control the expression of key developmental regulators.
1859:"LARP1 is regulated by the XIST/miR-374a axis and functions as an oncogene in non-small cell lung carcinoma" 892: 1558:"The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5'TOP sequence" 1556:
Lahr RM, Mack SM, Héroux A, Blagden SP, Bousquet-Antonelli C, Deragon JM, et al. (September 2015).
1903:"LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs" 2320: 2161: 2108: 190: 105: 1217: 1088: 1084: 1080: 1070: 1066: 1062: 1058: 1013: 1009: 1005: 1001: 991: 987: 983: 2267: 2224: 2187: 150: 2095:
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004).
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Hopkins TG, Mura M, Al-Ashtal HA, Lahr RM, Abd-Latip N, Sweeney K, et al. (February 2016).
1113: 1092: 1054: 1034: 979: 975: 1248:, which function in RNA storage and degradation. It has been suggested that LARP1 functions in 2259: 2216: 2179: 2136: 2083: 2037: 1985: 1934: 1880: 1839: 1790: 1739: 1687: 1638: 1587: 1538: 1489: 1426: 1382: 567: 553: 98: 42: 2304: 1656:
Mura M, Hopkins TG, Michael T, Abd-Latip N, Weir J, Aboagye E, et al. (September 2015).
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Lahr RM, Fonseca BD, Ciotti GE, Al-Ashtal HA, Jia JJ, Niklaus MR, et al. (April 2017).
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Tcherkezian J, Cargnello M, Romeo Y, Huttlin EL, Lavoie G, Gygi SP, et al. (Feb 2014).
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Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, et al. (October 1998).
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Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, et al. (November 2006).
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Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, et al. (August 2004).
2032: 2007: 1980: 1954:"La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs" 1953: 1929: 1902: 1834: 1809: 1785: 1758: 1734: 1709: 1682: 1657: 1633: 1606: 1582: 1557: 1533: 1508: 1484: 1459: 1241: 2131: 2096: 781: 776: 771: 766: 761: 756: 751: 746: 741: 736: 731: 726: 721: 716: 700: 695: 690: 685: 680: 675: 659: 654: 649: 644: 639: 634: 629: 624: 619: 614: 609: 2347: 1759:"LARP1 predict the prognosis for early-stage and AFP-normal hepatocellular carcinoma" 1253: 596: 2228: 1403:
Chauvet S, Maurel-Zaffran C, Miassod R, Jullien N, Pradel J, Aragnol D (July 2000).
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LARP1 binds to and regulates the translation of terminal oligopyrimidine motif (TOP
130: 2300: 2271: 2238:"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" 2191: 1658:"LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression" 388: 167: 154: 1901:
Hong S, Freeberg MA, Han T, Kamath A, Yao Y, Fukuda T, et al. (June 2017).
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National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
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Proceedings of the National Academy of Sciences of the United States of America
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Xie C, Huang L, Xie S, Xie D, Zhang G, Wang P, et al. (October 2013).
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Ye L, Lin ST, Mi YS, Liu Y, Ma Y, Sun HM, et al. (November 2016).
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10.1002/1097-0177(200007)218:3<401::AID-DVDY1009>3.0.CO;2-6
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Xu Z, Xu J, Lu H, Lin B, Cai S, Guo J, et al. (December 2017).
2097:"Large-scale characterization of HeLa cell nuclear phosphoproteins" 1445:"Entrez Gene: LARP1 La ribonucleoprotein domain family, member 1" 796: 792: 2296: 1237: 1200: 576: 122: 2060:
Horke S, Reumann K, Schweizer M, Will H, Heise T (June 2004).
1607:"The La-Related Proteins, a Family with Connections to Cancer" 1509:"A comprehensive analysis of the La-motif protein superfamily" 378: 2308: 543: 1224:, as well as in developing organs characterized by 1106: 1053: 1027: 974: 1302: 1300: 1298: 1281: 1279: 1277: 325: 224: 1703: 1701: 782:negative regulation of translational initiation 727:positive regulation of viral genome replication 16:Protein-coding gene in the species Homo sapiens 2001: 1999: 1398: 1396: 1307:GRCm38: Ensembl release 89: ENSMUSG00000037331 2328: 1507:Bousquet-Antonelli C, Deragon JM (May 2009). 8: 1896: 1894: 1286:GRCh38: Ensembl release 89: ENSG00000155506 2335: 2321: 1050: 971: 807: 592: 366: 265: 162: 60: 2253: 2173: 2130: 2120: 2077: 2031: 1979: 1969: 1928: 1918: 1874: 1833: 1784: 1774: 1733: 1681: 1632: 1622: 1581: 1532: 1483: 1420: 1376: 494:fetal liver hematopoietic progenitor cell 2006:Nykamp K, Lee MH, Kimble J (July 2008). 1252:to attenuate the abundance of conserved 1273: 630:eukaryotic initiation factor 4E binding 1605:Stavraka C, Blagden S (October 2015). 486:crypt of lieberkuhn of small intestine 20: 1240:) and can directly interact with the 722:positive regulation of macroautophagy 620:translation initiation factor binding 330: 291: 286: 229: 188: 183: 7: 2285: 2283: 1233:worse prognosis in cancer patients. 2066:The Journal of Biological Chemistry 2307:. You can help Knowledge (XXG) by 1103: 1024: 947: 928: 902: 883: 857: 838: 752:negative regulation of translation 747:positive regulation of translation 548: 466: 404: 383: 14: 1763:Journal of Translational Medicine 1196:that in humans is encoded by the 772:response to amino acid starvation 655:RNA 7-methylguanosine cap binding 440:lateral nuclear group of thalamus 2287: 566: 559: 552: 314: 307: 301: 278: 213: 206: 200: 175: 660:ribosomal small subunit binding 767:cellular response to rapamycin 615:translation activator activity 577:More reference expression data 532:More reference expression data 1: 2359:Human chromosome 5 gene stubs 732:cell population proliferation 299: 198: 1246:stress granules and P-bodies 1190:La-related protein 1 (LARP1) 2354:Genes on human chromosome 5 420:superior vestibular nucleus 2375: 2282: 2255:10.1016/j.cell.2006.09.026 696:cytoplasmic stress granule 2175:10.1016/j.cub.2004.07.051 1826:10.1007/s13277-016-5332-3 1342:"Mouse PubMed Reference:" 1324:"Human PubMed Reference:" 1176: 1171: 1167: 1160: 1144: 1131:Chr 5: 154.68 – 154.82 Mb 1125: 1110: 1077: 1046: 1031: 998: 967: 954: 950: 935: 931: 922: 909: 905: 890: 886: 877: 864: 860: 845: 841: 832: 817: 810: 806: 790: 777:regulation of translation 595: 591: 574: 551: 542: 529: 478: 469: 416: 407: 377: 369: 365: 348: 335: 298: 277: 268: 264: 247: 234: 197: 174: 165: 161: 116: 113: 103: 96: 91: 68: 63: 46: 41: 36: 32: 28: 23: 1776:10.1186/1479-5876-11-272 717:translational initiation 2122:10.1073/pnas.0404720101 1138:Chr 11: 57.9 – 57.95 Mb 2079:10.1074/jbc.M401017200 1714:Nucleic Acids Research 1562:Nucleic Acids Research 1476:10.1101/gad.231407.113 1409:Developmental Dynamics 1378:10.1093/dnares/5.5.277 436:middle temporal gyrus 293:Chromosome 11 (mouse) 2201:Nature Biotechnology 1876:10.3892/or.2017.6040 1674:10.1038/onc.2014.428 742:protein biosynthesis 191:Chromosome 5 (human) 64:List of PDB id codes 37:Available structures 2166:2004CBio...14.1436J 2113:2004PNAS..10112130B 2024:10.1261/rna.1066008 1971:10.7554/elife.24146 1920:10.7554/elife.25237 1820:(11): 14585–14594. 1726:10.1093/nar/gkv1515 1624:10.3390/biom5042701 1525:10.1261/rna.1478709 1218:dorsal root ganglia 640:mRNA 5'-UTR binding 635:mRNA 3'-UTR binding 506:trigeminal ganglion 444:trigeminal ganglion 2295:This article on a 1574:10.1093/nar/gkv748 912:ENSMUSG00000037331 762:mRNA stabilization 710:Biological process 701:polysomal ribosome 669:Cellular component 603:Molecular function 510:left lobe of liver 2316: 2315: 1187: 1186: 1183: 1182: 1156: 1155: 1121: 1120: 1100: 1099: 1042: 1041: 1021: 1020: 963: 962: 944: 943: 918: 917: 899: 898: 873: 872: 854: 853: 802: 801: 587: 586: 583: 582: 538: 537: 525: 524: 514:entorhinal cortex 463: 462: 361: 360: 260: 259: 155:LARP1 - orthologs 87: 86: 83: 82: 47:Ortholog search: 2366: 2337: 2330: 2323: 2291: 2284: 2275: 2257: 2232: 2195: 2177: 2144: 2134: 2124: 2091: 2081: 2072:(25): 26563–70. 2046: 2045: 2035: 2003: 1994: 1993: 1983: 1973: 1949: 1943: 1942: 1932: 1922: 1898: 1889: 1888: 1878: 1869:(6): 3659–3667. 1863:Oncology Reports 1854: 1848: 1847: 1837: 1805: 1799: 1798: 1788: 1778: 1754: 1748: 1747: 1737: 1705: 1696: 1695: 1685: 1653: 1647: 1646: 1636: 1626: 1602: 1596: 1595: 1585: 1553: 1547: 1546: 1536: 1504: 1498: 1497: 1487: 1455: 1449: 1448: 1441: 1435: 1434: 1424: 1400: 1391: 1390: 1380: 1356: 1350: 1349: 1338: 1332: 1331: 1320: 1314: 1304: 1293: 1283: 1169: 1168: 1140: 1133: 1116: 1104: 1095: 1051: 1047:RefSeq (protein) 1037: 1025: 1016: 972: 948: 929: 903: 884: 858: 839: 808: 650:cadherin binding 593: 579: 570: 563: 556: 549: 534: 482:primitive streak 474: 472:Top expressed in 467: 452:Brodmann area 23 412: 410:Top expressed in 405: 384: 367: 357: 344: 333: 318: 311: 305: 294: 282: 266: 256: 243: 232: 217: 210: 204: 193: 179: 163: 157: 108: 101: 78: 61: 55: 34: 33: 21: 2374: 2373: 2369: 2368: 2367: 2365: 2364: 2363: 2344: 2343: 2342: 2341: 2280: 2278: 2235: 2213:10.1038/nbt1240 2207:(10): 1285–92. 2198: 2160:(16): 1436–50. 2154:Current Biology 2147: 2107:(33): 12130–5. 2094: 2059: 2055: 2053:Further reading 2050: 2049: 2005: 2004: 1997: 1951: 1950: 1946: 1900: 1899: 1892: 1856: 1855: 1851: 1807: 1806: 1802: 1756: 1755: 1751: 1707: 1706: 1699: 1668:(39): 5025–36. 1655: 1654: 1650: 1604: 1603: 1599: 1568:(16): 8077–88. 1555: 1554: 1550: 1506: 1505: 1501: 1457: 1456: 1452: 1443: 1442: 1438: 1402: 1401: 1394: 1358: 1357: 1353: 1340: 1339: 1335: 1322: 1321: 1317: 1305: 1296: 1284: 1275: 1270: 1209: 1178:View/Edit Mouse 1173:View/Edit Human 1136: 1129: 1126:Location (UCSC) 1112: 1091: 1087: 1083: 1079: 1073: 1069: 1065: 1061: 1057: 1033: 1012: 1008: 1004: 1000: 994: 990: 986: 982: 978: 893:ENSG00000155506 786: 757:TORC1 signaling 705: 664: 625:protein binding 610:RNA cap binding 575: 565: 564: 558: 557: 530: 521: 516: 512: 508: 504: 500: 496: 492: 488: 484: 470: 459: 454: 450: 446: 442: 438: 434: 430: 426: 424:pars reticulata 422: 408: 352: 339: 332:11|11 B1.3 331: 321: 320: 319: 312: 292: 269:Gene location ( 251: 238: 230: 220: 219: 218: 211: 189: 166:Gene location ( 117: 104: 97: 70: 48: 17: 12: 11: 5: 2372: 2370: 2362: 2361: 2356: 2346: 2345: 2340: 2339: 2332: 2325: 2317: 2314: 2313: 2292: 2277: 2276: 2233: 2196: 2145: 2092: 2056: 2054: 2051: 2048: 2047: 2018:(7): 1378–89. 1995: 1944: 1890: 1849: 1814:Tumour Biology 1800: 1749: 1720:(3): 1227–46. 1697: 1648: 1617:(4): 2701–22. 1597: 1548: 1499: 1450: 1436: 1392: 1351: 1333: 1315: 1294: 1272: 1271: 1269: 1266: 1208: 1205: 1185: 1184: 1181: 1180: 1175: 1165: 1164: 1158: 1157: 1154: 1153: 1151: 1149: 1142: 1141: 1134: 1127: 1123: 1122: 1119: 1118: 1108: 1107: 1101: 1098: 1097: 1075: 1074: 1048: 1044: 1043: 1040: 1039: 1029: 1028: 1022: 1019: 1018: 996: 995: 969: 965: 964: 961: 960: 952: 951: 945: 942: 941: 933: 932: 926: 920: 919: 916: 915: 907: 906: 900: 897: 896: 888: 887: 881: 875: 874: 871: 870: 862: 861: 855: 852: 851: 843: 842: 836: 830: 829: 824: 819: 815: 814: 804: 803: 800: 799: 788: 787: 785: 784: 779: 774: 769: 764: 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1575: 1571: 1567: 1563: 1559: 1552: 1549: 1544: 1540: 1535: 1530: 1526: 1522: 1519:(5): 750–64. 1518: 1514: 1510: 1503: 1500: 1495: 1491: 1486: 1481: 1477: 1473: 1470:(4): 357–71. 1469: 1465: 1461: 1454: 1451: 1446: 1440: 1437: 1432: 1428: 1423: 1418: 1415:(3): 401–13. 1414: 1410: 1406: 1399: 1397: 1393: 1388: 1384: 1379: 1374: 1371:(5): 277–86. 1370: 1366: 1362: 1355: 1352: 1347: 1343: 1337: 1334: 1329: 1325: 1319: 1316: 1312: 1308: 1303: 1301: 1299: 1295: 1291: 1287: 1282: 1280: 1278: 1274: 1267: 1265: 1261: 1259: 1255: 1251: 1247: 1243: 1239: 1234: 1231: 1227: 1223: 1219: 1215: 1206: 1204: 1202: 1199: 1195: 1192:is a 150 kDa 1191: 1179: 1174: 1170: 1166: 1163: 1159: 1152: 1150: 1147: 1143: 1139: 1135: 1132: 1128: 1124: 1117: 1115: 1109: 1105: 1102: 1096: 1094: 1090: 1086: 1082: 1076: 1072: 1068: 1064: 1060: 1056: 1052: 1049: 1045: 1038: 1036: 1030: 1026: 1023: 1017: 1015: 1011: 1007: 1003: 997: 993: 989: 985: 981: 977: 973: 970: 968:RefSeq (mRNA) 966: 959: 958: 953: 949: 946: 940: 939: 934: 930: 927: 925: 921: 914: 913: 908: 904: 901: 895: 894: 889: 885: 882: 880: 876: 869: 868: 863: 859: 856: 850: 849: 844: 840: 837: 835: 831: 828: 825: 823: 820: 816: 813: 809: 805: 798: 794: 789: 783: 780: 778: 775: 773: 770: 768: 765: 763: 760: 758: 755: 753: 750: 748: 745: 743: 740: 738: 737:TOR signaling 735: 733: 730: 728: 725: 723: 720: 718: 715: 714: 712: 709: 708: 702: 699: 697: 694: 692: 689: 687: 684: 682: 681:TORC1 complex 679: 677: 674: 673: 671: 668: 667: 661: 658: 656: 653: 651: 648: 646: 643: 641: 638: 636: 633: 631: 628: 626: 623: 621: 618: 616: 613: 611: 608: 607: 605: 602: 601: 598: 597:Gene ontology 594: 590: 578: 573: 569: 562: 555: 550: 547: 545: 541: 533: 528: 517: 513: 509: 505: 501: 497: 493: 489: 485: 481: 480: 477: 473: 468: 465: 456:renal medulla 455: 451: 447: 443: 439: 435: 432:Pars compacta 431: 427: 423: 419: 418: 415: 411: 406: 403: 402: 399: 397: 393: 391: 390: 386: 385: 382: 380: 376: 372: 368: 364: 356: 351: 347: 343: 338: 328: 324: 317: 310: 304: 297: 289: 285: 281: 276: 272: 267: 263: 255: 250: 246: 242: 237: 227: 223: 216: 209: 203: 196: 192: 186: 182: 178: 173: 169: 164: 160: 156: 152: 148: 144: 140: 136: 132: 128: 124: 120: 112: 107: 100: 95: 90: 79: 77: 73: 67: 62: 59: 58: 54: 51: 44: 40: 35: 31: 27: 22: 19: 2309:expanding it 2301:chromosome 5 2294: 2279: 2245: 2241: 2204: 2200: 2157: 2153: 2104: 2100: 2069: 2065: 2015: 2011: 1961: 1957: 1947: 1910: 1906: 1866: 1862: 1852: 1817: 1813: 1803: 1766: 1762: 1752: 1717: 1713: 1665: 1661: 1651: 1614: 1611:Biomolecules 1610: 1600: 1565: 1561: 1551: 1516: 1512: 1502: 1467: 1463: 1453: 1439: 1412: 1408: 1368: 1365:DNA Research 1364: 1354: 1345: 1336: 1327: 1318: 1262: 1235: 1210: 1197: 1189: 1188: 1111: 1089:NP_001354648 1085:NP_001354647 1081:NP_001354646 1078: 1071:NP_001354645 1067:NP_001354644 1063:NP_001354643 1059:NP_001354642 1032: 1014:NM_001367719 1010:NM_001367718 1006:NM_001367717 1002:NM_001367716 999: 992:NM_001367715 988:NM_001367714 984:NM_001367713 955: 936: 910: 891: 865: 846: 826: 821: 394: 387: 252:154,817,605 239:154,682,986 114:External IDs 69: 18: 1230:mesenchymal 1222:spinal cord 645:RNA binding 353:57,952,860 340:57,899,890 92:Identifiers 2348:Categories 1313:, May 2017 1292:, May 2017 1268:References 1226:epithelial 398:(ortholog) 135:HomoloGene 2299:on human 1464:Genes Dev 1114:NP_082727 1093:NP_291029 1055:NP_056130 1035:NM_028451 980:NM_033551 976:NM_015315 812:Orthologs 676:cytoplasm 143:GeneCards 2264:17081983 2229:14294292 2221:16964243 2184:15324660 2141:15302935 2088:15060081 2042:18515547 1990:28379136 1939:28650797 1885:29039571 1844:27614686 1795:24159927 1744:26717985 1692:25531318 1662:Oncogene 1643:26501340 1592:26206669 1543:19299548 1494:24532714 1431:10878606 1309:– 1288:– 1250:P-bodies 1207:Function 1162:Wikidata 791:Sources: 691:polysome 686:membrane 498:epiblast 2272:7827573 2192:2371325 2162:Bibcode 2109:Bibcode 2033:2441978 1981:5419741 1930:5484620 1835:5126195 1786:3814951 1769:: 272. 1735:4756840 1683:4430325 1634:4693254 1583:4652764 1534:2673062 1485:3937514 1387:9872452 1311:Ensembl 1290:Ensembl 1194:protein 924:UniProt 879:Ensembl 818:Species 797:QuickGO 448:pylorus 373:pattern 131:1890165 99:Aliases 2270:  2262:  2227:  2219:  2190:  2182:  2139:  2132:514446 2129:  2086:  2040:  2030:  1988:  1978:  1937:  1927:  1883:  1842:  1832:  1793:  1783:  1742:  1732:  1690:  1680:  1641:  1631:  1590:  1580:  1541:  1531:  1492:  1482:  1429:  1385:  1242:5' cap 1148:search 1146:PubMed 957:Q6ZQ58 938:Q6PKG0 834:Entrez 544:BioGPS 518:somite 231:5q33.2 123:612059 2303:is a 2268:S2CID 2225:S2CID 2188:S2CID 1958:eLife 1907:eLife 1238:mRNAs 1198:LARP1 867:73158 848:23367 827:Mouse 822:Human 793:Amigo 396:Mouse 389:Human 336:Start 271:Mouse 235:Start 168:Human 147:LARP1 106:LARP1 24:LARP1 2305:stub 2297:gene 2260:PMID 2242:Cell 2217:PMID 2180:PMID 2137:PMID 2084:PMID 2038:PMID 1986:PMID 1935:PMID 1881:PMID 1840:PMID 1791:PMID 1740:PMID 1688:PMID 1639:PMID 1588:PMID 1539:PMID 1490:PMID 1427:PMID 1383:PMID 1258:MAPK 1220:and 1201:gene 379:Bgee 327:Band 288:Chr. 226:Band 185:Chr. 139:9089 119:OMIM 76:5C0V 72:4ZC4 53:RCSB 50:PDBe 2250:doi 2246:127 2209:doi 2170:doi 2127:PMC 2117:doi 2105:101 2074:doi 2070:279 2028:PMC 2020:doi 2012:RNA 1976:PMC 1966:doi 1925:PMC 1915:doi 1871:doi 1830:PMC 1822:doi 1781:PMC 1771:doi 1730:PMC 1722:doi 1678:PMC 1670:doi 1629:PMC 1619:doi 1578:PMC 1570:doi 1529:PMC 1521:doi 1513:RNA 1480:PMC 1472:doi 1417:doi 1413:218 1373:doi 1254:Ras 1214:SSB 349:End 248:End 151:OMA 127:MGI 43:PDB 2350:: 2266:. 2258:. 2244:. 2240:. 2223:. 2215:. 2205:24 2203:. 2186:. 2178:. 2168:. 2158:14 2156:. 2152:. 2135:. 2125:. 2115:. 2103:. 2099:. 2082:. 2068:. 2064:. 2036:. 2026:. 2016:14 2014:. 2010:. 1998:^ 1984:. 1974:. 1964:. 1960:. 1956:. 1933:. 1923:. 1913:. 1909:. 1905:. 1893:^ 1879:. 1867:38 1865:. 1861:. 1838:. 1828:. 1818:37 1816:. 1812:. 1789:. 1779:. 1767:11 1765:. 1761:. 1738:. 1728:. 1718:44 1716:. 1712:. 1700:^ 1686:. 1676:. 1666:34 1664:. 1660:. 1637:. 1627:. 1613:. 1609:. 1586:. 1576:. 1566:43 1564:. 1560:. 1537:. 1527:. 1517:15 1515:. 1511:. 1488:. 1478:. 1468:28 1466:. 1462:. 1425:. 1411:. 1407:. 1395:^ 1381:. 1367:. 1363:. 1344:. 1326:. 1297:^ 1276:^ 795:/ 355:bp 342:bp 254:bp 241:bp 149:; 145:: 141:; 137:: 133:; 129:: 125:; 121:: 74:, 2336:e 2329:t 2322:v 2311:. 2274:. 2252:: 2231:. 2211:: 2194:. 2172:: 2164:: 2143:. 2119:: 2111:: 2090:. 2076:: 2044:. 2022:: 1992:. 1968:: 1962:6 1941:. 1917:: 1911:6 1887:. 1873:: 1846:. 1824:: 1797:. 1773:: 1746:. 1724:: 1694:. 1672:: 1645:. 1621:: 1615:5 1594:. 1572:: 1545:. 1523:: 1496:. 1474:: 1447:. 1433:. 1419:: 1389:. 1375:: 1369:5 1348:. 1330:. 1256:- 1228:- 273:) 170:) 153::

Index

PDB
PDBe
RCSB
4ZC4
5C0V
Aliases
LARP1
OMIM
612059
MGI
1890165
HomoloGene
9089
GeneCards
LARP1
OMA
LARP1 - orthologs
Human
Chromosome 5 (human)
Chr.
Chromosome 5 (human)
Chromosome 5 (human)
Genomic location for LARP1
Genomic location for LARP1
Band
bp
bp
Mouse
Chromosome 11 (mouse)
Chr.

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