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127:
152:
259:
158:
1207:
1005:
family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related
266:
165:
1187:
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126:
1151:"Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3"
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1111:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1093:
National Center for
Biotechnology Information, U.S. National Library of Medicine
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positive regulation of pathway-restricted SMAD protein phosphorylation
17:
938:
690:
1206:
653:
649:
1214:
990:
72:
614:
transforming growth factor beta receptor signaling pathway
609:
negative regulation of transcription by RNA polymerase II
328:
1226:
493:
899:
878:
852:
831:
1067:
1065:
1063:
1046:
1044:
1042:
59:, LEFTB, LEFTYB, left-right determination factor 1
275:
174:
1125:"Entrez Gene: Left-right determination factor 1"
537:transforming growth factor beta receptor binding
27:Protein-coding gene in the species Homo sapiens
1072:GRCm38: Ensembl release 89: ENSMUSG00000038793
1246:
8:
1051:GRCh38: Ensembl release 89: ENSG00000243709
1253:
1239:
1188:United States National Library of Medicine
664:
519:
316:
215:
112:
1166:
639:regulation of signaling receptor activity
1186:This article incorporates text from the
989:that in humans is encoded by the LEFTY1
1038:
29:
280:
241:
236:
179:
138:
133:
7:
1203:
1201:
604:determination of left/right symmetry
448:endothelial cell of lymphatic vessel
1225:. You can help Knowledge (XXG) by
1001:This gene encodes a member of the
896:
875:
849:
828:
804:
785:
759:
740:
714:
695:
589:multicellular organism development
498:
416:
354:
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25:
983:Left-right determination factor 1
1205:
624:SMAD protein signal transduction
264:
257:
251:
228:
163:
156:
150:
125:
584:regulation of apoptotic process
482:More reference expression data
444:Region I of hippocampus proper
1:
1277:Human chromosome 1 gene stubs
249:
148:
1272:Genes on human chromosome 1
1293:
1200:
619:regulation of MAPK cascade
370:mucosa of transverse colon
1107:"Mouse PubMed Reference:"
1089:"Human PubMed Reference:"
969:
964:
960:
953:
937:
931:Chr 1: 180.76 – 180.77 Mb
924:Chr 1: 225.89 – 225.91 Mb
918:
903:
882:
871:
856:
835:
824:
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66:
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53:
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41:
37:
32:
1168:10.1074/jbc.M404979200
547:growth factor activity
436:lateral plate mesoderm
634:BMP signaling pathway
406:cerebellar hemisphere
563:extracellular region
468:skin of external ear
243:Chromosome 1 (mouse)
141:Chromosome 1 (human)
599:heart morphogenesis
568:extracellular space
464:islet of Langerhans
398:epithelium of colon
1213:This article on a
1190:, which is in the
769:ENSMUSG00000038793
577:Biological process
556:Cellular component
530:Molecular function
440:primitive endoderm
105:LEFTY1 - orthologs
1234:
1233:
1149:Besser D (2004).
980:
979:
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949:
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542:cytokine activity
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16:(Redirected from
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1161:(43): 45076–84.
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1079:
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962:
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872:RefSeq (protein)
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829:
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741:
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665:
629:cell development
520:
499:
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422:Top expressed in
417:
374:body of pancreas
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360:Top expressed in
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1142:Further reading
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999:
971:View/Edit Mouse
966:View/Edit Human
929:
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919:Location (UCSC)
905:
884:
858:
837:
750:ENSG00000243709
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219:Gene location (
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116:Gene location (
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321:RNA expression
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26:
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14:
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1199:
1196:
1195:
1193:
1192:public domain
1189:
1178:
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1156:
1155:J. Biol. Chem
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877:
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848:
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840:
834:
830:
827:
825:RefSeq (mRNA)
823:
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797:
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791:
787:
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558:
555:
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524:Gene ontology
521:
517:
505:
500:
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495:
491:
483:
478:
467:
463:
459:
455:
451:
447:
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217:
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205:
200:
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136:
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119:
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90:
86:
82:
78:
74:
70:
62:
57:
50:
45:
40:
36:
31:
19:
1227:expanding it
1219:chromosome 1
1212:
1197:
1185:
1184:
1158:
1154:
1128:. Retrieved
1119:
1110:
1101:
1092:
1083:
1000:
982:
981:
904:
883:
857:
836:
812:
793:
767:
748:
722:
703:
683:
678:
432:neural plate
344:
337:
303:180,765,965
290:180,762,587
202:225,911,382
189:225,886,282
64:External IDs
456:ankle joint
390:endometrium
282:1|1 H4
42:Identifiers
1266:Categories
1130:2016-08-03
1078:, May 2017
1057:, May 2017
1033:References
1008:pseudogene
348:(ortholog)
85:HomoloGene
1217:on human
907:NP_034224
886:NP_066277
860:NM_010094
839:NM_020997
669:Orthologs
93:GeneCards
1177:15308665
1074:–
1053:–
1014:See also
1003:TGF-beta
997:Function
955:Wikidata
648:Sources:
402:monocyte
394:appendix
382:testicle
1076:Ensembl
1055:Ensembl
1025:Lefty-1
987:protein
781:UniProt
736:Ensembl
675:Species
654:QuickGO
323:pattern
181:1q42.12
49:Aliases
1175:
941:search
939:PubMed
814:Q64280
795:O75610
691:Entrez
494:BioGPS
460:embryo
378:rectum
97:LEFTY1
81:107405
73:603037
56:LEFTY1
33:LEFTY1
18:LEFTY1
1221:is a
1020:Lefty
985:is a
724:13590
705:10637
684:Mouse
679:Human
650:Amigo
386:gonad
346:Mouse
339:Human
286:Start
221:Mouse
185:Start
118:Human
89:49231
1223:stub
1215:gene
1173:PMID
991:gene
329:Bgee
277:Band
238:Chr.
176:Band
135:Chr.
69:OMIM
1163:doi
1159:279
502:n/a
452:lip
299:End
198:End
101:OMA
77:MGI
1268::
1171:.
1157:.
1153:.
1109:.
1091:.
1062:^
1041:^
1010:.
993:.
652:/
305:bp
292:bp
204:bp
191:bp
99:;
95::
91:;
87::
83:;
79::
75:;
71::
1254:e
1247:t
1240:v
1229:.
1194:.
1179:.
1165::
1133:.
1113:.
1095:.
223:)
120:)
103::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
