310:
287:
184:
209:
561:
316:
215:
29:
2200:
1179:
of LGP2 is able to inhibit RIG-I-mediated antiviral signaling both in the presence and absence of viral ligands. This inhibition of RIG-I signaling is not dependent upon the ability of LGP2 to bind viral ligands and is therefore not due to ligand competition. Although LGP2 binds to dsRNA with higher
1174:
LGP2 has been shown to directly interact with RIG-I through its C-terminal repressor domain (RD). The primary contact sites in this interaction is likely between the RD of LGP2 and the CARD or helicase domain of RIG-I as it is seen with RIG-I self-association, but this has not been confirmed. The
1711:
Burel SA, Machemer T, Ragone FL, Kato H, Cauntay P, Greenlee S, Salim A, Gaarde WA, Hung G, Peralta R, Freier SM, Henry SP (July 2012). "Unique O-Methoxyethyl Ribose-DNA Chimeric
Oligonucleotide Induces an Atypical Melanoma Differentiation-Associated Gene 5-Dependent Induction of Type I Interferon
55:
1284:
Cui Y, Li M, Walton KD, Sun K, Hanover JA, Furth PA, Hennighausen L (Dec 2001). "The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue".
2051:
323:
222:
1824:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
2044:
834:
815:
145:
1621:
Yoneyama M, Kikuchi M, Matsumoto K, Imaizumi T, Miyagishi M, Taira K, Foy E, Loo YM, Gale M, Akira S, Yonehara S, Kato A, Fujita T (September 2005).
2279:
2245:
2037:
2264:
1261:
1243:
1760:
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
309:
52:
1041:
1034:
286:
1662:
Wang Y, Ludwig J, Schuberth C, Goldeck M, Schlee M, Li H, Juranek S, Sheng G, Micura R, Tuschl T, Hartmann G, Patel DJ (July 2010).
1941:
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".
1330:
2274:
2095:
1230:
1209:
1180:
affinity, it is dispensable for RIG-I-mediated recognition of synthetic dsRNA ligands. RIG-I, when overexpressed and in LGP2
1152:. LGP2 has been found to be essential for producing effective antiviral responses against many viruses that are recognized by
208:
183:
1577:
Rothenfusser S, Goutagny N, DiPerna G, Gong M, Monks BG, Schoenemeyer A, Yamamoto M, Akira S, Fitzgerald KA (October 2005).
1226:
2269:
1452:
Satoh T, Kato H, Kumagai Y, Yoneyama M, Sato S, Matsushita K, Tsujimura T, Fujita T, Akira S, Takeuchi O (January 2010).
1205:
2150:
2110:
2072:
2064:
125:
322:
221:
2238:
315:
214:
1579:"The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I"
879:
133:
1351:"Paramyxovirus V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon induction"
2090:
1664:"Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I"
1623:"Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity"
860:
1175:
helicase activity of LGP2 has been found to be essential for its positive regulation of RIG-I signaling.
2231:
1168:
197:
2029:
2060:
1950:
1866:
1531:
1465:
1149:
112:
1167:
domains, its effect on downstream antiviral signaling is likely due to interaction with dsRNA viral
2123:
2100:
1105:
1518:
Saito T, Hirai R, Loo YM, Owen D, Johnson CL, Sinha SC, Akira S, Fujita T, Gale M (January 2007).
2080:
1974:
1737:
157:
1855:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
1017:
996:
970:
949:
2118:
2017:
1966:
1929:
1894:
1841:
1812:
1777:
1729:
1693:
1644:
1600:
1559:
1493:
1429:
1380:
1312:
1176:
105:
45:
2215:
1520:"Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2"
2085:
2007:
1999:
1958:
1919:
1884:
1874:
1833:
1802:
1769:
1721:
1683:
1675:
1634:
1590:
1549:
1539:
1483:
1473:
1419:
1411:
1370:
1362:
1302:
1294:
1181:
402:
333:
277:
232:
153:
560:
377:
1954:
1870:
1535:
1469:
2012:
1987:
1688:
1663:
1554:
1519:
1488:
1453:
1424:
1399:
1375:
1350:
1145:
28:
1889:
1854:
1837:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
668:
652:
647:
642:
637:
632:
627:
622:
617:
612:
607:
602:
2258:
2211:
2174:
1773:
1415:
1184:
studies, has been shown to induce antiviral response in the absence of viral ligand.
589:
137:
1988:"RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2"
1978:
1741:
395:
174:
161:
2178:
1639:
1622:
1595:
1578:
1266:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1248:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1164:
478:
1454:"LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses"
294:
191:
141:
1148:
in 2001, but its function has been found to be more relevant to the field of
2158:
1908:"Complete sequencing and characterization of 21,243 full-length human cDNAs"
1791:"Normalization and subtraction: two approaches to facilitate gene discovery"
1725:
1544:
1478:
779:
538:
416:
361:
348:
260:
247:
149:
2021:
1970:
1933:
1898:
1879:
1733:
1697:
1648:
1604:
1563:
1497:
1433:
1384:
1316:
1298:
1845:
1816:
1781:
1307:
1081:
1076:
2003:
1366:
1111:
1065:
924:
905:
1962:
1807:
1790:
1125:
891:
846:
1679:
82:
78:
74:
1114:
1049:
801:
2199:
1924:
1907:
2128:
1153:
1108:
764:
760:
2207:
2133:
1157:
1121:
569:
129:
2033:
1144:
LGP2 was first identified and characterized in the context of
1853:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1400:"Function and regulation of retinoic acid-inducible gene-I"
385:
2219:
116:, D11LGP2, D11lgp2e, LGP2, RLR-3, DEXH-box helicase 58
550:
1331:"Entrez Gene: LGP2 likely ortholog of mouse D11lgp2"
2167:
2149:
2109:
2071:
1010:
989:
963:
942:
740:
positive regulation of type I interferon production
720:
negative regulation of type I interferon production
1906:Ota T, Suzuki Y, Nishikawa T, et al. (2004).
1222:
1220:
1218:
1201:
1199:
1197:
332:
231:
1616:
1614:
1349:Childs K, Randall R, Goodbourn S (April 2012).
16:Protein-coding gene in the species Homo sapiens
1279:
1277:
1275:
1227:GRCm38: Ensembl release 89: ENSMUSG00000017830
745:negative regulation of RIG-I signaling pathway
735:positive regulation of MDA-5 signaling pathway
705:positive regulation of RIG-I signaling pathway
685:negative regulation of MDA-5 signaling pathway
2239:
2045:
1513:
1511:
1509:
1507:
1344:
1342:
1340:
715:negative regulation of innate immune response
8:
1447:
1445:
1443:
1206:GRCh38: Ensembl release 89: ENSG00000108771
1136:(Laboratory of Genetics and Physiology 2).
2246:
2232:
2052:
2038:
2030:
775:
585:
373:
272:
169:
63:
2011:
1923:
1888:
1878:
1806:
1687:
1638:
1594:
1553:
1543:
1487:
1477:
1423:
1374:
1306:
1094:Probable ATP-dependent RNA helicase DHX58
1789:Bonaldo MF, Lennon G, Soares MB (1997).
1193:
18:
337:
298:
293:
236:
195:
190:
7:
2196:
2194:
1171:or the other RLRs (RIG-I and MDA5).
690:regulation of innate immune response
1398:Matsumiya T, Stafforini DM (2010).
2218:. You can help Knowledge (XXG) by
1007:
986:
960:
939:
915:
896:
870:
851:
825:
806:
555:
473:
411:
390:
14:
1117:that in humans is encoded by the
2198:
1416:10.1615/critrevimmunol.v30.i6.10
559:
321:
314:
308:
285:
220:
213:
207:
182:
27:
2280:Human chromosome 17 gene stubs
570:More reference expression data
539:More reference expression data
1:
2065:Pattern recognition receptors
1986:Komuro A, Horvath CM (2007).
1838:10.1016/S0378-1119(97)00411-3
306:
205:
2265:Genes on human chromosome 17
1859:Proc. Natl. Acad. Sci. U.S.A
1774:10.1016/0378-1119(94)90802-8
1524:Proc. Natl. Acad. Sci. U.S.A
1458:Proc. Natl. Acad. Sci. U.S.A
1640:10.4049/jimmunol.175.5.2851
1596:10.4049/jimmunol.175.8.5260
643:double-stranded RNA binding
633:single-stranded RNA binding
2296:
2193:
1262:"Mouse PubMed Reference:"
1244:"Human PubMed Reference:"
1150:innate antiviral immunity
1080:
1075:
1071:
1064:
1048:
1042:Chr 11: 100.59 – 100.6 Mb
1029:
1014:
993:
982:
967:
946:
935:
922:
918:
903:
899:
890:
877:
873:
858:
854:
845:
832:
828:
813:
809:
800:
785:
778:
774:
758:
710:defense response to virus
588:
584:
567:
558:
549:
536:
485:
476:
423:
414:
384:
376:
372:
355:
342:
305:
284:
275:
271:
254:
241:
204:
181:
172:
168:
123:
120:
110:
103:
98:
71:
66:
49:
44:
39:
35:
26:
21:
1102:RIG-I-like receptor LGP2
2275:Intracellular receptors
2091:Formyl peptide receptor
1726:10.1124/jpet.112.193789
1714:J. Pharmacol. Exp. Ther
1545:10.1073/pnas.0606699104
1479:10.1073/pnas.0912986107
1035:Chr 17: 42.1 – 42.11 Mb
1880:10.1073/pnas.242603899
1668:Nat. Struct. Mol. Biol
1299:10.1006/geno.2001.6661
1140:Structure and function
725:innate immune response
513:lumbar spinal ganglion
509:mucous cell of stomach
1098:RIG-I-like receptor 3
750:response to bacterium
695:immune system process
517:stroma of bone marrow
339:11 D|11 63.52 cM
300:Chromosome 11 (mouse)
198:Chromosome 17 (human)
2270:RIG-I-like receptors
2061:Innate immune system
2004:10.1128/JVI.01325-06
1367:10.1128/JVI.06405-11
1128:encoded by the gene
443:right adrenal cortex
67:List of PDB id codes
40:Available structures
2124:RIG-I-like receptor
2101:Complement receptor
2073:Membrane-bound_PRRs
1963:10.1038/nature04209
1955:2005Natur.437.1173R
1871:2002PNAS...9916899M
1536:2007PNAS..104..582S
1470:2010PNAS..107.1512S
1106:RIG-I-like receptor
501:seminiferous tubule
447:left adrenal cortex
439:right adrenal gland
431:right lobe of liver
2206:This article on a
2096:Scavenger receptor
2081:Toll-like receptor
1808:10.1101/gr.6.9.791
1404:Crit. Rev. Immunol
880:ENSMUSG00000017830
678:Biological process
662:Cellular component
648:hydrolase activity
608:nucleotide binding
596:Molecular function
435:right uterine tube
2227:
2226:
2188:
2187:
2119:NOD-like receptor
1865:(26): 16899–903.
1680:10.1038/nsmb.1863
1163:Since LGP2 lacks
1091:
1090:
1087:
1086:
1060:
1059:
1025:
1024:
1004:
1003:
978:
977:
957:
956:
931:
930:
912:
911:
886:
885:
867:
866:
841:
840:
822:
821:
770:
769:
700:response to virus
623:metal ion binding
613:helicase activity
580:
579:
576:
575:
545:
544:
532:
531:
470:
469:
368:
367:
267:
266:
162:DHX58 - orthologs
94:
93:
90:
89:
50:Ortholog search:
2287:
2248:
2241:
2234:
2202:
2195:
2111:Cytoplasmic_PRRs
2086:Mannose receptor
2054:
2047:
2040:
2031:
2025:
2015:
1998:(24): 12332–42.
1982:
1949:(7062): 1173–8.
1937:
1927:
1902:
1892:
1882:
1849:
1820:
1810:
1785:
1746:
1745:
1708:
1702:
1701:
1691:
1659:
1653:
1652:
1642:
1618:
1609:
1608:
1598:
1574:
1568:
1567:
1557:
1547:
1515:
1502:
1501:
1491:
1481:
1449:
1438:
1437:
1427:
1395:
1389:
1388:
1378:
1346:
1335:
1334:
1327:
1321:
1320:
1310:
1281:
1270:
1269:
1258:
1252:
1251:
1240:
1234:
1224:
1213:
1203:
1073:
1072:
1044:
1037:
1020:
1008:
999:
987:
983:RefSeq (protein)
973:
961:
952:
940:
916:
897:
871:
852:
826:
807:
776:
618:zinc ion binding
586:
572:
563:
556:
541:
481:
479:Top expressed in
474:
419:
417:Top expressed in
412:
391:
374:
364:
351:
340:
325:
318:
312:
301:
289:
273:
263:
250:
239:
224:
217:
211:
200:
186:
170:
164:
115:
108:
85:
64:
58:
37:
36:
31:
19:
2295:
2294:
2290:
2289:
2288:
2286:
2285:
2284:
2255:
2254:
2253:
2252:
2191:
2189:
2184:
2168:Other/ungrouped
2163:
2145:
2105:
2067:
2058:
2028:
1985:
1940:
1905:
1852:
1832:(1–2): 149–56.
1823:
1788:
1759:
1755:
1753:Further reading
1750:
1749:
1710:
1709:
1705:
1661:
1660:
1656:
1620:
1619:
1612:
1576:
1575:
1571:
1517:
1516:
1505:
1451:
1450:
1441:
1397:
1396:
1392:
1348:
1347:
1338:
1329:
1328:
1324:
1283:
1282:
1273:
1260:
1259:
1255:
1242:
1241:
1237:
1225:
1216:
1204:
1195:
1190:
1142:
1082:View/Edit Mouse
1077:View/Edit Human
1040:
1033:
1030:Location (UCSC)
1016:
995:
969:
948:
861:ENSG00000108771
754:
673:
657:
628:protein binding
568:
537:
528:
523:
519:
515:
511:
507:
503:
499:
495:
491:
477:
466:
461:
457:
453:
449:
445:
441:
437:
433:
429:
415:
359:
346:
338:
328:
327:
326:
319:
299:
276:Gene location (
258:
245:
237:
227:
226:
225:
218:
196:
173:Gene location (
124:
111:
104:
73:
51:
17:
12:
11:
5:
2293:
2291:
2283:
2282:
2277:
2272:
2267:
2257:
2256:
2251:
2250:
2243:
2236:
2228:
2225:
2224:
2203:
2186:
2185:
2183:
2182:
2171:
2169:
2165:
2164:
2162:
2161:
2155:
2153:
2147:
2146:
2144:
2143:
2142:
2141:
2136:
2131:
2121:
2115:
2113:
2107:
2106:
2104:
2103:
2098:
2093:
2088:
2083:
2077:
2075:
2069:
2068:
2059:
2057:
2056:
2049:
2042:
2034:
2027:
2026:
1983:
1938:
1925:10.1038/ng1285
1903:
1850:
1821:
1801:(9): 791–806.
1786:
1768:(1–2): 171–4.
1756:
1754:
1751:
1748:
1747:
1703:
1654:
1610:
1569:
1503:
1439:
1410:(6): 489–513.
1390:
1361:(7): 3411–21.
1336:
1322:
1308:2027.42/175385
1271:
1253:
1235:
1214:
1192:
1191:
1189:
1186:
1177:Overexpression
1146:mammary tissue
1141:
1138:
1096:also known as
1089:
1088:
1085:
1084:
1079:
1069:
1068:
1062:
1061:
1058:
1057:
1055:
1053:
1046:
1045:
1038:
1031:
1027:
1026:
1023:
1022:
1012:
1011:
1005:
1002:
1001:
991:
990:
984:
980:
979:
976:
975:
965:
964:
958:
955:
954:
944:
943:
937:
933:
932:
929:
928:
920:
919:
913:
910:
909:
901:
900:
894:
888:
887:
884:
883:
875:
874:
868:
865:
864:
856:
855:
849:
843:
842:
839:
838:
830:
829:
823:
820:
819:
811:
810:
804:
798:
797:
792:
787:
783:
782:
772:
771:
768:
767:
756:
755:
753:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
692:
687:
681:
679:
675:
674:
672:
671:
665:
663:
659:
658:
656:
655:
650:
645:
640:
635:
630:
625:
620:
615:
610:
605:
599:
597:
593:
592:
582:
581:
578:
577:
574:
573:
565:
564:
553:
547:
546:
543:
542:
534:
533:
530:
529:
527:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
483:
482:
471:
468:
467:
465:
464:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
421:
420:
408:
407:
399:
388:
382:
381:
378:RNA expression
370:
369:
366:
365:
357:
353:
352:
344:
341:
336:
330:
329:
320:
313:
307:
303:
302:
297:
291:
290:
282:
281:
269:
268:
265:
264:
256:
252:
251:
243:
240:
235:
229:
228:
219:
212:
206:
202:
201:
194:
188:
187:
179:
178:
166:
165:
122:
118:
117:
109:
101:
100:
96:
95:
92:
91:
88:
87:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2292:
2281:
2278:
2276:
2273:
2271:
2268:
2266:
2263:
2262:
2260:
2249:
2244:
2242:
2237:
2235:
2230:
2229:
2223:
2221:
2217:
2213:
2212:chromosome 17
2209:
2204:
2201:
2197:
2192:
2180:
2176:
2175:Immunophilins
2173:
2172:
2170:
2166:
2160:
2157:
2156:
2154:
2152:
2151:Secreted_PRRs
2148:
2140:
2137:
2135:
2132:
2130:
2127:
2126:
2125:
2122:
2120:
2117:
2116:
2114:
2112:
2108:
2102:
2099:
2097:
2094:
2092:
2089:
2087:
2084:
2082:
2079:
2078:
2076:
2074:
2070:
2066:
2062:
2055:
2050:
2048:
2043:
2041:
2036:
2035:
2032:
2023:
2019:
2014:
2009:
2005:
2001:
1997:
1993:
1989:
1984:
1980:
1976:
1972:
1968:
1964:
1960:
1956:
1952:
1948:
1944:
1939:
1935:
1931:
1926:
1921:
1917:
1913:
1909:
1904:
1900:
1896:
1891:
1886:
1881:
1876:
1872:
1868:
1864:
1860:
1856:
1851:
1847:
1843:
1839:
1835:
1831:
1827:
1822:
1818:
1814:
1809:
1804:
1800:
1796:
1792:
1787:
1783:
1779:
1775:
1771:
1767:
1763:
1758:
1757:
1752:
1743:
1739:
1735:
1731:
1727:
1723:
1720:(1): 150–62.
1719:
1715:
1707:
1704:
1699:
1695:
1690:
1685:
1681:
1677:
1673:
1669:
1665:
1658:
1655:
1650:
1646:
1641:
1636:
1633:(5): 2851–8.
1632:
1628:
1624:
1617:
1615:
1611:
1606:
1602:
1597:
1592:
1589:(8): 5260–8.
1588:
1584:
1580:
1573:
1570:
1565:
1561:
1556:
1551:
1546:
1541:
1537:
1533:
1529:
1525:
1521:
1514:
1512:
1510:
1508:
1504:
1499:
1495:
1490:
1485:
1480:
1475:
1471:
1467:
1464:(4): 1512–7.
1463:
1459:
1455:
1448:
1446:
1444:
1440:
1435:
1431:
1426:
1421:
1417:
1413:
1409:
1405:
1401:
1394:
1391:
1386:
1382:
1377:
1372:
1368:
1364:
1360:
1356:
1352:
1345:
1343:
1341:
1337:
1332:
1326:
1323:
1318:
1314:
1309:
1304:
1300:
1296:
1293:(3): 129–34.
1292:
1288:
1280:
1278:
1276:
1272:
1267:
1263:
1257:
1254:
1249:
1245:
1239:
1236:
1232:
1228:
1223:
1221:
1219:
1215:
1211:
1207:
1202:
1200:
1198:
1194:
1187:
1185:
1183:
1178:
1172:
1170:
1166:
1161:
1159:
1155:
1151:
1147:
1139:
1137:
1135:
1131:
1127:
1123:
1120:
1116:
1113:
1110:
1107:
1103:
1099:
1095:
1083:
1078:
1074:
1070:
1067:
1063:
1056:
1054:
1051:
1047:
1043:
1039:
1036:
1032:
1028:
1021:
1019:
1013:
1009:
1006:
1000:
998:
992:
988:
985:
981:
974:
972:
966:
962:
959:
953:
951:
945:
941:
938:
936:RefSeq (mRNA)
934:
927:
926:
921:
917:
914:
908:
907:
902:
898:
895:
893:
889:
882:
881:
876:
872:
869:
863:
862:
857:
853:
850:
848:
844:
837:
836:
831:
827:
824:
818:
817:
812:
808:
805:
803:
799:
796:
793:
791:
788:
784:
781:
777:
773:
766:
762:
757:
751:
748:
746:
743:
741:
738:
736:
733:
731:
730:viral process
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
682:
680:
677:
676:
670:
667:
666:
664:
661:
660:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
604:
601:
600:
598:
595:
594:
591:
590:Gene ontology
587:
583:
571:
566:
562:
557:
554:
552:
548:
540:
535:
524:
520:
516:
512:
508:
505:adrenal gland
504:
500:
496:
492:
488:
487:
484:
480:
475:
472:
462:
458:
454:
451:apex of heart
450:
446:
442:
438:
434:
430:
426:
425:
422:
418:
413:
410:
409:
406:
404:
400:
398:
397:
393:
392:
389:
387:
383:
379:
375:
371:
363:
358:
354:
350:
345:
335:
331:
324:
317:
311:
304:
296:
292:
288:
283:
279:
274:
270:
262:
257:
253:
249:
244:
234:
230:
223:
216:
210:
203:
199:
193:
189:
185:
180:
176:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
119:
114:
107:
102:
97:
86:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
2220:expanding it
2205:
2190:
2138:
1995:
1991:
1946:
1942:
1915:
1911:
1862:
1858:
1829:
1825:
1798:
1794:
1765:
1761:
1717:
1713:
1706:
1674:(7): 781–7.
1671:
1667:
1657:
1630:
1626:
1586:
1582:
1572:
1530:(2): 582–7.
1527:
1523:
1461:
1457:
1407:
1403:
1393:
1358:
1354:
1325:
1290:
1286:
1265:
1256:
1247:
1238:
1173:
1162:
1143:
1133:
1132:is known as
1129:
1118:
1101:
1097:
1093:
1092:
1015:
994:
968:
947:
923:
904:
878:
859:
833:
814:
794:
789:
493:spermatocyte
463:tibial nerve
401:
394:
360:100,595,097
347:100,585,710
121:External IDs
72:
2179:Cyclophilin
1918:(1): 40–5.
1712:Response".
1104:(RLR) is a
1100:(RLR-3) or
653:ATP binding
638:RNA binding
603:DNA binding
489:granulocyte
427:granulocyte
259:42,112,714
246:42,101,404
99:Identifiers
2259:Categories
1912:Nat. Genet
1795:Genome Res
1627:J. Immunol
1583:J. Immunol
1233:, May 2017
1212:, May 2017
1188:References
1182:knock-down
459:left ovary
405:(ortholog)
142:HomoloGene
2210:on human
2159:Collectin
1018:NP_084426
997:NP_077024
971:NM_030150
950:NM_024119
780:Orthologs
669:cytoplasm
497:spermatid
150:GeneCards
2022:17020950
1992:J. Virol
1971:16189514
1934:14702039
1899:12477932
1734:22505629
1698:20581823
1649:16116171
1605:16210631
1564:17190814
1498:20080593
1434:21175414
1385:22301134
1355:J. Virol
1317:11735219
1287:Genomics
1229:–
1208:–
1112:helicase
1066:Wikidata
759:Sources:
455:monocyte
2013:1676302
1979:4427026
1951:Bibcode
1867:Bibcode
1846:9373149
1817:8889548
1782:8125298
1742:1899247
1689:3744876
1555:1766428
1532:Bibcode
1489:2824407
1466:Bibcode
1425:3099591
1376:3302505
1231:Ensembl
1210:Ensembl
1126:protein
1124:. The
892:UniProt
847:Ensembl
786:Species
765:QuickGO
380:pattern
238:17q21.2
138:1931560
106:Aliases
2020:
2010:
1977:
1969:
1943:Nature
1932:
1897:
1890:139241
1887:
1844:
1815:
1780:
1740:
1732:
1696:
1686:
1647:
1603:
1562:
1552:
1496:
1486:
1432:
1422:
1383:
1373:
1315:
1169:ligand
1115:enzyme
1052:search
1050:PubMed
925:Q99J87
906:Q96C10
802:Entrez
551:BioGPS
525:embryo
521:embryo
130:608588
2214:is a
2129:RIG-I
1975:S2CID
1738:S2CID
1154:RIG-I
1130:DHX58
1119:DHX58
1109:dsRNA
835:80861
816:79132
795:Mouse
790:Human
761:Amigo
403:Mouse
396:Human
343:Start
278:Mouse
242:Start
175:Human
154:DHX58
146:69371
113:DHX58
22:DHX58
2216:stub
2208:gene
2139:LGP2
2134:MDA5
2018:PMID
1967:PMID
1930:PMID
1895:PMID
1842:PMID
1826:Gene
1813:PMID
1778:PMID
1762:Gene
1730:PMID
1694:PMID
1645:PMID
1601:PMID
1560:PMID
1494:PMID
1430:PMID
1381:PMID
1313:PMID
1165:CARD
1158:MDA5
1156:and
1134:LGP2
1122:gene
386:Bgee
334:Band
295:Chr.
233:Band
192:Chr.
126:OMIM
83:3EQT
79:2W4R
75:2RQA
56:RCSB
53:PDBe
2008:PMC
2000:doi
1959:doi
1947:437
1920:doi
1885:PMC
1875:doi
1834:doi
1830:200
1803:doi
1770:doi
1766:138
1722:doi
1718:342
1684:PMC
1676:doi
1635:doi
1631:175
1591:doi
1587:175
1550:PMC
1540:doi
1528:104
1484:PMC
1474:doi
1462:107
1420:PMC
1412:doi
1371:PMC
1363:doi
1303:hdl
1295:doi
356:End
255:End
158:OMA
134:MGI
46:PDB
2261::
2063::
2016:.
2006:.
1996:80
1994:.
1990:.
1973:.
1965:.
1957:.
1945:.
1928:.
1916:36
1914:.
1910:.
1893:.
1883:.
1873:.
1863:99
1861:.
1857:.
1840:.
1828:.
1811:.
1797:.
1793:.
1776:.
1764:.
1736:.
1728:.
1716:.
1692:.
1682:.
1672:17
1670:.
1666:.
1643:.
1629:.
1625:.
1613:^
1599:.
1585:.
1581:.
1558:.
1548:.
1538:.
1526:.
1522:.
1506:^
1492:.
1482:.
1472:.
1460:.
1456:.
1442:^
1428:.
1418:.
1408:30
1406:.
1402:.
1379:.
1369:.
1359:86
1357:.
1353:.
1339:^
1311:.
1301:.
1291:78
1289:.
1274:^
1264:.
1246:.
1217:^
1196:^
1160:.
763:/
362:bp
349:bp
261:bp
248:bp
156:;
152::
148:;
144::
140:;
136::
132:;
128::
81:,
77:,
2247:e
2240:t
2233:v
2222:.
2181:)
2177:(
2053:e
2046:t
2039:v
2024:.
2002::
1981:.
1961::
1953::
1936:.
1922::
1901:.
1877::
1869::
1848:.
1836::
1819:.
1805::
1799:6
1784:.
1772::
1744:.
1724::
1700:.
1678::
1651:.
1637::
1607:.
1593::
1566:.
1542::
1534::
1500:.
1476::
1468::
1436:.
1414::
1387:.
1365::
1333:.
1319:.
1305::
1297::
1268:.
1250:.
280:)
177:)
160::
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