141:
118:
392:
147:
1747:
1656:
Thorleifsson G, Magnusson KP, Sulem P, Walters GB, Gudbjartsson DF, Stefansson H, Jonsson T, Jonasdottir A, Jonasdottir A, Stefansdottir G, Masson G, Hardarson GA, Petursson H, Arnarsson A, Motallebipour M, Wallerman O, Wadelius C, Gulcher JR, Thorsteinsdottir U, Kong A, Jonasson F, Stefansson K
1162:
Thorleifsson G, Magnusson KP, Sulem P, Walters GB, Gudbjartsson DF, Stefansson H, Jonsson T, Jonasdottir A, Jonasdottir A, Stefansdottir G, Masson G, Hardarson GA, Petursson H, Arnarsson A, Motallebipour M, Wallerman O, Wadelius C, Gulcher JR, Thorsteinsdottir U, Kong A, Jonasson F, Stefansson K
905:
gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in
1619:
Cenizo V, André V, Reymermier C, Sommer P, Damour O, Perrier E (2007). "LOXL as a target to increase the elastin content in adult skin: a dill extract induces the LOXL gene expression".
1349:
Molnar J, Fong KS, He QP, Hayashi K, Kim Y, Fong SF, Fogelgren B, Szauter KM, Mink M, Csiszar K (2003). "Structural and functional diversity of lysyl oxidase and the LOX-like proteins".
1485:
Jung ST, Kim MS, Seo JY, Kim HC, Kim Y (2004). "Purification of enzymatically active human lysyl oxidase and lysyl oxidase-like protein from
Escherichia coli inclusion bodies".
154:
1551:"Lysyl oxidase-like and lysyl oxidase are present in the dermis and epidermis of a skin equivalent and in human skin and are associated to elastic fibers"
620:
601:
79:
1448:
Goy A, Gilles F, Remache Y, Zelenetz AD (2000). "Physical linkage of the lysyl oxidase-like (LOXL1) gene to the PML gene on human chromosome 15q22".
1816:
1792:
1294:
1051:
1033:
922:
is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and
140:
823:
117:
1072:
1020:
1016:
918:
end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The
59:
1312:
Kagan HM, Li W (2003). "Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell".
967:
153:
1785:
1708:
Damji KF (2007). "Progress in understanding pseudoexfoliation syndrome and pseudoexfoliation-associated glaucoma".
935:
146:
663:
67:
1821:
1586:"The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers"
1778:
1811:
1670:
1176:
955:
939:
46:
1380:"A novel human cDNA with a predicted protein similar to lysyl oxidase maps to chromosome 15q24-q25"
1088:"A novel human cDNA with a predicted protein similar to lysyl oxidase maps to chromosome 15q24-q25"
1549:
Noblesse E, Cenizo V, Bouez C, Borel A, Gleyzal C, Peyrol S, Jacob MP, Sommer P, Damour O (2004).
1696:
1644:
1473:
1337:
1202:
91:
801:
780:
754:
733:
1725:
1688:
1636:
1607:
1572:
1537:
1502:
1465:
1436:
1401:
1366:
1329:
1300:
1290:
1251:
1243:
1220:
Liu X, Zhao Y, Gao J, Pawlyk B, Starcher B, Spencer JA, Yanagisawa H, Zuo J, Li T (Feb 2004).
1194:
1144:
1109:
39:
1762:
1584:
Thomassin L, Werneck CC, Broekelmann TJ, Gleyzal C, Hornstra IK, Mecham RP, Sommer P (2006).
1415:"A new gene with sequence and structural similarity to the gene encoding human lysyl oxidase"
1127:
Schlötzer-Schrehardt U, Naumann GO (2006). "Ocular and systemic pseudoexfoliation syndrome".
1717:
1678:
1628:
1597:
1562:
1527:
1494:
1457:
1426:
1391:
1358:
1321:
1282:
1233:
1184:
1136:
1099:
233:
164:
108:
391:
87:
1659:"Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma"
1514:
Liu X, Zhao Y, Gao J, Pawlyk B, Starcher B, Spencer JA, Yanagisawa H, Zuo J, Li T (2004).
1165:"Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma"
208:
1674:
1180:
1498:
1396:
1379:
1362:
1286:
1104:
1087:
535:
530:
525:
520:
515:
499:
494:
489:
484:
479:
474:
469:
453:
448:
443:
438:
433:
1805:
1758:
1632:
1567:
1550:
902:
420:
1700:
1648:
1477:
1341:
1206:
947:
226:
71:
1273:
Csiszar K (2001). "Lysyl oxidases: a novel multifunctional amine oxidase family".
444:
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
1056:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1038:
National Center for
Biotechnology Information, U.S. National Library of Medicine
309:
1140:
923:
919:
915:
125:
75:
1247:
1683:
1658:
1431:
1414:
1189:
1164:
565:
192:
179:
83:
1729:
1692:
1640:
1611:
1602:
1585:
1576:
1541:
1506:
1469:
1370:
1333:
1304:
1255:
1198:
1148:
1440:
1405:
1113:
863:
858:
907:
847:
708:
689:
943:
911:
675:
632:
1461:
1325:
883:
831:
587:
95:
1746:
1721:
1532:
1515:
1238:
1221:
993:
988:
983:
971:
1516:"Elastic fiber homeostasis requires lysyl oxidase-like 1 protein"
1222:"Elastic fiber homeostasis requires lysyl oxidase-like 1 protein"
550:
546:
1754:
890:
63:
400:
951:
1086:
Kenyon K, Modi WS, Contente S, Friedman RM (September 1993).
369:
247:
1277:. Progress in Nucleic Acid Research and Molecular Biology.
216:
1766:
381:
934:
Polymorphisms of the LOXL1 gene are associated with
1378:Kenyon K, Modi WS, Contente S, Friedman RM (1993).
794:
773:
747:
726:
1012:
1010:
1008:
163:
914:. A highly conserved amino acid sequence at the
18:Protein-coding gene in the species Homo sapiens
1017:GRCm38: Ensembl release 89: ENSMUSG00000032334
1786:
8:
942:contains abnormal amounts of cross-linked,
1793:
1779:
561:
416:
204:
103:
1682:
1601:
1566:
1531:
1430:
1395:
1237:
1188:
1103:
1073:"Entrez Gene: LOXL1 lysyl oxidase-like 1"
1067:
1065:
500:collagen-containing extracellular matrix
1004:
20:
168:
129:
124:
7:
1743:
1741:
1092:The Journal of Biological Chemistry
1765:. You can help Knowledge (XXG) by
1413:Kim Y, Boyd CD, Csiszar K (1995).
901:This gene encodes a member of the
886:which in humans is encoded by the
791:
770:
744:
723:
699:
680:
654:
637:
611:
592:
386:
304:
242:
221:
14:
1275:Prog. Nucleic Acid Res. Mol. Biol
531:extracellular matrix organization
454:protein-lysine 6-oxidase activity
50:, LOL, LOXL, lysyl oxidase like 1
1745:
1633:10.1111/j.1600-0625.2006.00442.x
1568:10.1111/j.0022-202X.2004.22330.x
390:
152:
145:
139:
116:
1817:Human chromosome 15 gene stubs
926:to each member of the family.
526:response to lipopolysaccharide
401:More reference expression data
370:More reference expression data
1:
1499:10.1016/S1046-5928(03)00217-1
1397:10.1016/S0021-9258(17)46643-9
1363:10.1016/s1570-9639(03)00053-0
1287:10.1016/S0079-6603(01)70012-8
1105:10.1016/S0021-9258(17)46643-9
946:-like fibrillar material and
348:tunica media of zone of aorta
137:
1232:(2). United States: 178–82.
950:. When this happens in the
266:stromal cell of endometrium
1838:
1740:
936:pseudoexfoliation syndrome
286:retinal pigment epithelium
1141:10.1016/j.ajo.2006.01.047
1052:"Mouse PubMed Reference:"
1034:"Human PubMed Reference:"
862:
857:
853:
846:
830:
813:
798:
777:
766:
751:
730:
719:
706:
702:
687:
683:
674:
661:
657:
644:
640:
631:
618:
614:
599:
595:
586:
571:
564:
560:
544:
536:peptidyl-lysine oxidation
419:
415:
398:
389:
380:
367:
316:
307:
254:
245:
215:
207:
203:
186:
173:
136:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
966:LOXL1 has been shown to
1684:10.1126/science.1146554
1432:10.1074/jbc.270.13.7176
1190:10.1126/science.1146554
876:Lysyl oxidase homolog 1
434:oxidoreductase activity
344:external carotid artery
1603:10.1074/jbc.M506832200
1351:Biochim. Biophys. Acta
938:, a disease where the
824:Chr 9: 58.2 – 58.22 Mb
1450:Cytogenet. Cell Genet
930:Clinical significance
352:stroma of bone marrow
270:right coronary artery
956:exfoliation glaucoma
940:extracellular matrix
480:extracellular region
475:extracellular matrix
278:left coronary artery
131:Chromosome 9 (mouse)
1675:2007Sci...317.1397T
1555:J. Invest. Dermatol
1487:Protein Expr. Purif
1181:2007Sci...317.1397T
516:protein deamination
495:extracellular space
170:9 B|9 31.65 cM
1753:This article on a
1710:Can. J. Ophthalmol
1669:(5843): 1397–400.
1175:(5843): 1397–400.
664:ENSMUSG00000032334
509:Biological process
463:Cellular component
439:copper ion binding
427:Molecular function
328:epithelium of lens
294:anterior pituitary
1774:
1773:
1462:10.1159/000015477
1326:10.1002/jcb.10413
1296:978-0-12-540070-1
1129:Am. J. Ophthalmol
873:
872:
869:
868:
842:
841:
809:
808:
788:
787:
762:
761:
741:
740:
715:
714:
696:
695:
670:
669:
651:
650:
627:
626:
608:
607:
556:
555:
521:aorta development
490:acrosomal vesicle
485:basement membrane
449:metal ion binding
411:
410:
407:
406:
376:
375:
363:
362:
301:
300:
199:
198:
96:LOXL1 - orthologs
1829:
1795:
1788:
1781:
1749:
1742:
1733:
1704:
1686:
1652:
1615:
1605:
1596:(52): 42848–55.
1580:
1570:
1545:
1535:
1510:
1481:
1444:
1434:
1409:
1399:
1374:
1345:
1314:J. Cell. Biochem
1308:
1260:
1259:
1241:
1217:
1211:
1210:
1192:
1159:
1153:
1152:
1124:
1118:
1117:
1107:
1083:
1077:
1076:
1069:
1060:
1059:
1048:
1042:
1041:
1030:
1024:
1014:
878:, also known as
855:
854:
826:
819:
804:
792:
783:
771:
767:RefSeq (protein)
757:
745:
736:
724:
700:
681:
655:
638:
612:
593:
562:
417:
403:
394:
387:
372:
324:efferent ductule
312:
310:Top expressed in
305:
250:
248:Top expressed in
243:
222:
205:
195:
182:
171:
156:
149:
143:
132:
120:
104:
98:
49:
42:
21:
1837:
1836:
1832:
1831:
1830:
1828:
1827:
1826:
1802:
1801:
1800:
1799:
1738:
1736:
1722:10.3129/I07-158
1707:
1655:
1618:
1583:
1548:
1513:
1484:
1447:
1425:(13): 7176–82.
1412:
1390:(25): 18435–7.
1377:
1348:
1311:
1297:
1272:
1268:
1266:Further reading
1263:
1219:
1218:
1214:
1161:
1160:
1156:
1126:
1125:
1121:
1098:(25): 18435–7.
1085:
1084:
1080:
1071:
1070:
1063:
1050:
1049:
1045:
1032:
1031:
1027:
1015:
1006:
1002:
980:
964:
932:
899:
864:View/Edit Mouse
859:View/Edit Human
822:
817:
814:Location (UCSC)
800:
779:
753:
732:
540:
504:
458:
399:
368:
359:
354:
350:
346:
342:
338:
334:
330:
326:
322:
320:ascending aorta
308:
297:
292:
288:
284:
280:
276:
272:
268:
264:
262:ascending aorta
260:
246:
190:
177:
169:
159:
158:
157:
150:
130:
107:Gene location (
58:
45:
38:
19:
12:
11:
5:
1835:
1833:
1825:
1824:
1822:Lysyl oxidases
1819:
1814:
1804:
1803:
1798:
1797:
1790:
1783:
1775:
1772:
1771:
1750:
1735:
1734:
1705:
1653:
1616:
1581:
1546:
1533:10.1038/ng1297
1511:
1482:
1445:
1410:
1375:
1357:(1–2): 220–4.
1346:
1309:
1295:
1269:
1267:
1264:
1262:
1261:
1239:10.1038/ng1297
1212:
1154:
1135:(5): 921–937.
1119:
1078:
1061:
1043:
1025:
1003:
1001:
998:
997:
996:
991:
986:
979:
976:
963:
960:
931:
928:
898:
895:
871:
870:
867:
866:
861:
851:
850:
844:
843:
840:
839:
837:
835:
828:
827:
820:
815:
811:
810:
807:
806:
796:
795:
789:
786:
785:
775:
774:
768:
764:
763:
760:
759:
749:
748:
742:
739:
738:
728:
727:
721:
717:
716:
713:
712:
704:
703:
697:
694:
693:
685:
684:
678:
672:
671:
668:
667:
659:
658:
652:
649:
648:
642:
641:
635:
629:
628:
625:
624:
616:
615:
609:
606:
605:
597:
596:
590:
584:
583:
578:
573:
569:
568:
558:
557:
554:
553:
542:
541:
539:
538:
533:
528:
523:
518:
512:
510:
506:
505:
503:
502:
497:
492:
487:
482:
477:
472:
466:
464:
460:
459:
457:
456:
451:
446:
441:
436:
430:
428:
424:
423:
413:
412:
409:
408:
405:
404:
396:
395:
384:
378:
377:
374:
373:
365:
364:
361:
360:
358:
357:
353:
349:
345:
341:
337:
333:
329:
325:
321:
317:
314:
313:
302:
299:
298:
296:
295:
291:
287:
283:
282:saphenous vein
279:
275:
271:
267:
263:
259:
258:thoracic aorta
255:
252:
251:
239:
238:
230:
219:
213:
212:
209:RNA expression
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
128:
122:
121:
113:
112:
100:
99:
56:
52:
51:
43:
35:
34:
30:
29:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
1834:
1823:
1820:
1818:
1815:
1813:
1810:
1809:
1807:
1796:
1791:
1789:
1784:
1782:
1777:
1776:
1770:
1768:
1764:
1760:
1759:chromosome 15
1756:
1751:
1748:
1744:
1739:
1731:
1727:
1723:
1719:
1715:
1711:
1706:
1702:
1698:
1694:
1690:
1685:
1680:
1676:
1672:
1668:
1664:
1660:
1654:
1650:
1646:
1642:
1638:
1634:
1630:
1627:(8): 574–81.
1626:
1622:
1621:Exp. Dermatol
1617:
1613:
1609:
1604:
1599:
1595:
1591:
1590:J. Biol. Chem
1587:
1582:
1578:
1574:
1569:
1564:
1561:(3): 621–30.
1560:
1556:
1552:
1547:
1543:
1539:
1534:
1529:
1526:(2): 178–82.
1525:
1521:
1517:
1512:
1508:
1504:
1500:
1496:
1492:
1488:
1483:
1479:
1475:
1471:
1467:
1463:
1459:
1456:(1–2): 22–4.
1455:
1451:
1446:
1442:
1438:
1433:
1428:
1424:
1420:
1419:J. Biol. Chem
1416:
1411:
1407:
1403:
1398:
1393:
1389:
1385:
1384:J. Biol. Chem
1381:
1376:
1372:
1368:
1364:
1360:
1356:
1352:
1347:
1343:
1339:
1335:
1331:
1327:
1323:
1320:(4): 660–72.
1319:
1315:
1310:
1306:
1302:
1298:
1292:
1288:
1284:
1280:
1276:
1271:
1270:
1265:
1257:
1253:
1249:
1245:
1240:
1235:
1231:
1227:
1223:
1216:
1213:
1208:
1204:
1200:
1196:
1191:
1186:
1182:
1178:
1174:
1170:
1166:
1158:
1155:
1150:
1146:
1142:
1138:
1134:
1130:
1123:
1120:
1115:
1111:
1106:
1101:
1097:
1093:
1089:
1082:
1079:
1074:
1068:
1066:
1062:
1057:
1053:
1047:
1044:
1039:
1035:
1029:
1026:
1022:
1018:
1013:
1011:
1009:
1005:
999:
995:
992:
990:
987:
985:
982:
981:
977:
975:
973:
969:
961:
959:
957:
953:
949:
948:glycoproteins
945:
941:
937:
929:
927:
925:
921:
917:
913:
909:
904:
903:lysyl oxidase
896:
894:
892:
889:
885:
881:
877:
865:
860:
856:
852:
849:
845:
838:
836:
833:
829:
825:
821:
816:
812:
805:
803:
797:
793:
790:
784:
782:
776:
772:
769:
765:
758:
756:
750:
746:
743:
737:
735:
729:
725:
722:
720:RefSeq (mRNA)
718:
711:
710:
705:
701:
698:
692:
691:
686:
682:
679:
677:
673:
666:
665:
660:
656:
653:
647:
643:
639:
636:
634:
630:
623:
622:
617:
613:
610:
604:
603:
598:
594:
591:
589:
585:
582:
579:
577:
574:
570:
567:
563:
559:
552:
548:
543:
537:
534:
532:
529:
527:
524:
522:
519:
517:
514:
513:
511:
508:
507:
501:
498:
496:
493:
491:
488:
486:
483:
481:
478:
476:
473:
471:
468:
467:
465:
462:
461:
455:
452:
450:
447:
445:
442:
440:
437:
435:
432:
431:
429:
426:
425:
422:
421:Gene ontology
418:
414:
402:
397:
393:
388:
385:
383:
379:
371:
366:
355:
351:
347:
343:
339:
335:
331:
327:
323:
319:
318:
315:
311:
306:
303:
293:
289:
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41:
36:
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27:
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16:
1767:expanding it
1752:
1737:
1716:(5): 657–8.
1713:
1709:
1666:
1662:
1624:
1620:
1593:
1589:
1558:
1554:
1523:
1519:
1493:(2): 240–6.
1490:
1486:
1453:
1449:
1422:
1418:
1387:
1383:
1354:
1350:
1317:
1313:
1278:
1274:
1229:
1225:
1215:
1172:
1168:
1157:
1132:
1128:
1122:
1095:
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1081:
1055:
1046:
1037:
1028:
965:
962:Interactions
933:
900:
887:
879:
875:
874:
799:
778:
752:
731:
707:
688:
662:
645:
619:
600:
580:
575:
356:vas deferens
332:aortic valve
232:
225:
55:External IDs
15:
1812:Human genes
290:gallbladder
191:58,220,469
178:58,195,021
33:Identifiers
1806:Categories
1520:Nat. Genet
1226:Nat. Genet
1023:, May 2017
1000:References
924:chemotaxis
920:N-terminus
916:C-terminus
236:(ortholog)
76:HomoloGene
1757:on human
1248:1061-4036
958:results.
908:collagens
802:NP_034859
781:NP_005567
755:NM_010729
734:NM_005576
566:Orthologs
470:cytoplasm
84:GeneCards
1730:17891191
1701:22289307
1693:17690259
1657:(2007).
1649:10622527
1641:16842595
1612:16251195
1577:15086544
1542:14745449
1507:14550642
1478:41968837
1470:10773658
1371:12686136
1342:23651213
1334:12577300
1305:11642359
1281:: 1–32.
1256:14745449
1207:22289307
1199:17690259
1163:(2007).
1149:16678509
1019:–
978:See also
968:interact
897:Function
882:, is an
848:Wikidata
545:Sources:
336:calvaria
1671:Bibcode
1663:Science
1441:7706256
1406:7689553
1177:Bibcode
1169:Science
1114:7689553
1021:Ensembl
944:amyloid
912:elastin
676:UniProt
633:Ensembl
572:Species
551:QuickGO
274:urethra
211:pattern
40:Aliases
1728:
1699:
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1205:
1197:
1147:
1112:
884:enzyme
834:search
832:PubMed
709:P97873
690:Q08397
588:Entrez
382:BioGPS
72:106096
64:153456
1761:is a
1697:S2CID
1645:S2CID
1474:S2CID
1338:S2CID
1203:S2CID
994:LOXL4
989:LOXL3
984:LOXL2
972:FBLN5
970:with
888:LOXL1
880:LOXL1
621:16949
581:Mouse
576:Human
547:Amigo
340:ankle
234:Mouse
227:Human
174:Start
109:Mouse
88:LOXL1
47:LOXL1
24:LOXL1
1763:stub
1755:gene
1726:PMID
1689:PMID
1637:PMID
1608:PMID
1573:PMID
1538:PMID
1503:PMID
1466:PMID
1437:PMID
1402:PMID
1367:PMID
1355:1647
1330:PMID
1301:PMID
1291:ISBN
1252:PMID
1244:ISSN
1195:PMID
1145:PMID
1110:PMID
910:and
891:gene
602:4016
217:Bgee
165:Band
126:Chr.
80:4074
60:OMIM
1718:doi
1679:doi
1667:317
1629:doi
1598:doi
1594:280
1563:doi
1559:122
1528:doi
1495:doi
1458:doi
1427:doi
1423:270
1392:doi
1388:268
1359:doi
1322:doi
1283:doi
1234:doi
1185:doi
1173:317
1137:doi
1133:141
1100:doi
1096:268
952:eye
818:n/a
646:n/a
187:End
92:OMA
68:MGI
1808::
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1064:^
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1007:^
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549:/
193:bp
180:bp
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62::
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1787:t
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94::
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