7523:
5307:
328:
305:
4136:
202:
227:
5352:
586:
579:
5292:
5337:
5322:
334:
233:
1909:, while its absence is linked to increased cancer invasion. However, the exact mechanisms require further study, as other studies have shown that LRP1 may also promote cancer invasion. One possible mechanism for the inhibitory function of LRP1 in cancer involves the LRP1-dependent endocytosis of 2′-hydroxycinnamaldehyde (HCA), resulting in decreased
1833:. LRP1 mediates pathways that interact with astrocytes and pericytes, which are associated with the blood-brain barrier. In support of this, LRP1 expression is reduced in endothelial cells as a result of normal aging and Alzheimer's disease in humans and animal models of the disease. This clearance mechanism is modulated by the
5306:
1837:
isoforms, with the presence of the apoE4 isoform resulting in reduced transcytosis of Aβ in in vitro models of the blood-brain barrier. The reduced clearance appears to be, at least in part, as a result of an increase in the ectodomain shedding of LRP1 by sheddases, resulting in the formation of
1797:
allows the free LRP1 to compete with the membrane-bound form and prevent their clearance. Several sheddases have been implicated in the proteolytic cleavage of LRP1 such as ADAM10, ADAM12, ADAM17 and MT1-MMP. LRP1 is also continuously endocytosed from the membrane and recycled back to the cell
57:
31:
4715:
Wang S, Herndon ME, Ranganathan S, Godyna S, Lawler J, Argraves WS, et al. (Mar 2004). "Internalization but not binding of thrombospondin-1 to low density lipoprotein receptor-related protein-1 requires heparan sulfate proteoglycans".
4900:"Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor"
4761:"Cellular internalization and degradation of thrombospondin-1 is mediated by the amino-terminal heparin binding domain (HBD). High affinity interaction of dimeric HBD with the low density lipoprotein receptor-related protein"
4512:"The carboxyl-terminal domain of lipoprotein lipase binds to the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) and mediates binding of normal very low density lipoproteins to LRP"
4151:"Low-density lipoprotein receptor-related protein 1 prevents early atherosclerosis by limiting lesional apoptosis and inflammatory Ly-6Chigh monocytosis: evidence that the effects are not apolipoprotein E dependent"
5315:: NMR SOLUTION STRUCTURE OF COMPLEMENT-LIKE REPEAT CR3 FROM THE LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN (LRP). EVIDENCE FOR SPECIFIC BINDING TO THE RECEPTOR BINDING DOMAIN OF HUMAN ALPHA-2 MACROGLOBULIN
5351:
4676:"Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function between LRP and the PDGF"
2683:
2371:
1873:(Chylomicron remnants, VLDL) and other proatherogenic ligands from the circulation. LRP1 has a cholesterol-independent role in atherosclerosis by modulating the activity and cellular localization of the
4430:"Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction"
6253:
2943:
Myklebost O, Arheden K, Rogne S, Geurts van Kessel A, Mandahl N, Herz J, et al. (Jul 1989). "The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14".
3791:
Bachmeier C, Paris D, Beaulieu-Abdelahad D, Mouzon B, Mullan M, Crawford F (2013-01-01). "A multifaceted role for apoE in the clearance of beta-amyloid across the blood-brain barrier".
5392:
4553:"A carboxyl-terminal fragment of lipoprotein lipase binds to the low density lipoprotein receptor-related protein and inhibits lipase-mediated uptake of lipoprotein in cells"
5010:
Li Z, Dai J, Zheng H, Liu B, Caudill M (Mar 2002). "An integrated view of the roles and mechanisms of heat shock protein gp96-peptide complex in eliciting immune response".
4959:"Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity"
2896:"Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor"
7745:
7725:
3306:
Kang HS, Kim J, Lee HJ, Kwon BM, Lee DK, Hong SH (Aug 2014). "LRP1-dependent pepsin clearance induced by 2'-hydroxycinnamaldehyde attenuates breast cancer cell invasion".
341:
240:
7429:
1798:
surface. Though the role of LRP1 in apoptosis is unclear, it is required for tPA to bind LRP1 in order to trigger the ERK1/2 signal cascade and promote cell survival.
7773:
1753:
such as neurodegenerative diseases, atherosclerosis, and cancer. To elaborate, LRP1 mainly contributes to regulate protein activity by binding target proteins as a
7522:
6243:
134:, A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5, low density lipoprotein receptor-related protein 1, LDL receptor related protein 1, KPA, IGFBP3R1, IGFBP-3R
5291:
2797:
1826:
is the decrease of LRP1 mediated by the metabolism of the amyloid precursor protein, leading to decreased neuronal cholesterol and increased amyloid beta.
6223:
1224:
1658:, with the β-propeller postulated to displace the ligand at the ligand binding repeats. The transmembrane domain is the β-chain, which contains a 100-
1205:
163:
7085:
5409:
5385:
3397:"Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function"
7635:
4594:"The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor binds and mediates catabolism of bovine milk lipoprotein lipase"
7668:
5336:
6816:
2723:
2411:
1719:
5321:
2726:
2414:
1620:-binding domains (numbered I-IV) containing two, eight, ten, and eleven cysteine-rich complement-type repeats, respectively. These repeats bind
6804:
6582:
1918:
1869:
is the primary cause of cardiovascular disease such as stroke and heart attacks. In the liver LRP1 is important for the removal of atherogenic
2696:
2384:
7824:
6868:
6863:
6809:
6589:
5370:
5271:
2876:
1700:. LRP1 plays a key role in intracellular signaling and endocytosis, which implicates it in many cellular and biological processes, including
2858:
7829:
7700:
7422:
6322:
6248:
5378:
4032:
Boucher P, Gotthardt M, Li WP, Anderson RG, Herz J (Apr 2003). "LRP: role in vascular wall integrity and protection from atherosclerosis".
2695:
2383:
2714:
2402:
327:
54:
7351:
7346:
7341:
7336:
6263:
4309:"Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins"
1431:
1646:. Of the four domains, II and IV bind the majority of the protein's ligands. The EGF repeats and β-propeller domains serve to release
1424:
4085:"LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome"
2730:
2418:
304:
7663:
7316:
3985:"Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants"
3944:"Inactivation of the LRP1 intracellular NPxYxxL motif in LDLR-deficient mice enhances postprandial dyslipidemia and atherosclerosis"
1893:
LRP1 is involved in tumorigenesis, and is proposed to be a tumor suppressor. Notably, LRP1 functions in clearing proteases such as
2716:
2404:
7783:
7486:
6552:
3695:"Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway"
2727:
2415:
7415:
7120:
6614:
6300:
2845:
2824:
2329:
2317:
6759:
6295:
2263:
1774:
226:
201:
4802:"Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1"
2841:
2693:
2381:
5360:: Haddock model of the complex between double module of LRP, CR56, and first domain of receptor associated protein, RAP-d1.
3744:"Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier"
2729:
2709:
2703:
2698:
2417:
2397:
2391:
2386:
7673:
7655:
7256:
6728:
6723:
6668:
6402:
5851:
2721:
2701:
2409:
2389:
3548:"Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1"
2820:
7472:
6950:
6673:
2753:
2694:
2382:
2323:
1633:
143:
4368:"Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly"
6268:
4241:"Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein"
2712:
2711:
2690:
2400:
2399:
2378:
1950:
2731:
2720:
2707:
2706:
2705:
2419:
2408:
2395:
2394:
2393:
3597:"Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease"
2724:
2710:
2412:
2398:
340:
239:
6980:
5405:
2792:
2728:
2725:
2416:
2413:
5846:
5264:
2708:
2396:
1968:
1758:
1561:
333:
232:
3250:"Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells"
2734:
2733:
2691:
2687:
2422:
2421:
2379:
2375:
1885:
has an effect on atherosclerosis through the modulation of the extracellular matrix and inflammatory responses.
7507:
7030:
5925:
5243:
2732:
2722:
2719:
2718:
2717:
2702:
2700:
2699:
2697:
2689:
2688:
2686:
2420:
2410:
2407:
2406:
2405:
2390:
2388:
2387:
2385:
2377:
2376:
2374:
2023:
1269:
151:
2715:
2704:
2692:
2403:
2392:
2380:
1830:
2713:
2401:
7491:
6994:
2245:
1865:
Studies have elucidated different roles for LRP1 in cellular processes relevant for cardiovascular disease.
1519:
1250:
4135:
6337:
6332:
6327:
6317:
5624:
5552:
4635:"v-Src induces Shc binding to tyrosine 63 in the cytoplasmic domain of the LDL receptor-related protein 1"
1854:
1730:
4674:
Loukinova E, Ranganathan S, Kuznetsov S, Gorlatova N, Migliorini MM, Loukinov D, et al. (May 2002).
7683:
5681:
5599:
1996:
215:
5039:
van der Geer P (May 2002). "Phosphorylation of LRP1: regulation of transport and signal transduction".
4428:
Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, et al. (Aug 2000).
3343:"Inhibition of ADAM10 promotes the clearance of Aβ across the BBB by reducing LRP1 ectodomain shedding"
1937:, resulting in the release of MC mediators, activation of an inflammatory response, and development of
6918:
6631:
5257:
4911:
4320:
4096:
4041:
3896:
2239:
1790:
1621:
1829:
LRP1 is also implicated in the effective clearance of Aβ from the brain to the periphery across the
130:
7512:
6945:
6764:
3885:"Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance"
3644:
Storck SE, Meister S, Nahrath J, Meißner JN, Schubert N, Di
Spiezio A, et al. (January 2016).
2233:
2107:
2089:
1878:
1850:
1727:
1670:
1659:
1542:
7645:
6352:
6086:
5220:
5177:
5099:
4741:
4065:
3816:
3693:
Kang DE, Pietrzik CU, Baum L, Chevallier N, Merriam DE, Kounnas MZ, et al. (November 2000).
3219:
2335:
2137:
2131:
1689:
175:
1407:
1386:
1360:
1339:
4366:
Orr AW, Pedraza CE, Pallero MA, Elzie CA, Goicoechea S, Strickland DK, et al. (Jun 2003).
7587:
7582:
7577:
7572:
7542:
7482:
5212:
5169:
5134:
5091:
5056:
5027:
4988:
4939:
4880:
4831:
4782:
4733:
4697:
4656:
4615:
4574:
4533:
4492:
4451:
4397:
4348:
4289:
4262:
4221:
4180:
4124:
4057:
4014:
3965:
3924:
3865:
3808:
3773:
3724:
3675:
3626:
3577:
3528:
3479:
3428:
3374:
3323:
3279:
3211:
3067:
2960:
2925:
1902:
1636:
1585:
123:
47:
5191:"Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability"
3742:
Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, et al. (December 2000).
3190:"Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability"
7614:
7604:
7599:
7594:
7564:
7125:
6858:
6779:
6342:
5535:
5461:
5202:
5159:
5124:
5081:
5048:
5019:
4978:
4970:
4929:
4919:
4870:
4862:
4821:
4813:
4772:
4725:
4687:
4646:
4605:
4564:
4523:
4482:
4441:
4387:
4379:
4338:
4328:
4252:
4211:
4170:
4162:
4114:
4104:
4049:
4004:
3996:
3955:
3914:
3904:
3855:
3847:
3800:
3763:
3755:
3714:
3706:
3665:
3657:
3616:
3608:
3567:
3559:
3518:
3510:
3469:
3459:
3418:
3408:
3395:
Selvais C, D'Auria L, Tyteca D, Perrot G, Lemoine P, Troeberg L, et al. (August 2011).
3364:
3354:
3315:
3269:
3261:
3201:
3057:
3047:
2952:
2915:
2907:
2293:
2287:
1999:
1980:
1958:
1834:
1782:
1778:
1770:
1682:
1665:
tail. This tail contains two NPxY motifs that are responsible for the protein's function in
585:
578:
420:
351:
295:
250:
7760:
7735:
7609:
7407:
7185:
5721:
5716:
5639:
4551:
Nykjaer A, Nielsen M, Lookene A, Meyer N, Røigaard H, Etzerodt M, et al. (Dec 1994).
4200:"Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse"
1866:
1565:
1523:
1025:
positive regulation of insulin secretion involved in cellular response to glucose stimulus
395:
171:
5086:
5069:
4851:"Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation"
1853:. This defective clearance may contribute to the buildup of neurotoxic amyloid-beta that
5239:
4915:
4471:"CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin"
4324:
4100:
4045:
3900:
1822:) via LRP1 receptors on the cell surface. It has been theorized that a causal factor in
7640:
7531:
7502:
6970:
6392:
5903:
5706:
5129:
5113:"LDL receptor-related protein and the vascular wall: implications for atherothrombosis"
5112:
4875:
4866:
4850:
4826:
4801:
4392:
4367:
4216:
4199:
4175:
4150:
4119:
4084:
3919:
3884:
3860:
3835:
3670:
3645:
3621:
3596:
3572:
3547:
3523:
3498:
3474:
3447:
3423:
3396:
3369:
3342:
3274:
3249:
3062:
3035:
2911:
2113:
1914:
1823:
1786:
1738:
5052:
4610:
4593:
4569:
4552:
4528:
4511:
4487:
4470:
4343:
4308:
4166:
4009:
3984:
3768:
3743:
3719:
3694:
3248:
Roy A, Coum A, Marinescu VD, Põlajeva J, Smits A, Nelander S, et al. (Jun 2015).
2920:
2895:
2774:
2757:
2744:
1139:
1134:
1129:
1124:
1119:
1114:
1109:
1104:
1099:
1094:
1089:
1084:
1079:
1074:
1069:
1064:
1059:
1054:
1049:
1044:
1039:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
979:
974:
969:
964:
959:
954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
712:
707:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
30:
7818:
6940:
6397:
5488:
5207:
5190:
4983:
4958:
4934:
4899:
4510:
Williams SE, Inoue I, Tran H, Fry GL, Pladet MW, Iverius PH, et al. (Mar 1994).
3883:
Singh I, Sagare AP, Coma M, Perlmutter D, Gelein R, Bell RD, et al. (Sep 2013).
3206:
3189:
2956:
2035:
1934:
1625:
1609:
1597:
1593:
1553:
865:
negative regulation of platelet-derived growth factor receptor-beta signaling pathway
614:
5224:
5181:
5103:
4759:
Mikhailenko I, Krylov D, Argraves KM, Roberts DD, Liau G, Strickland DK (Mar 1997).
4745:
4592:
Chappell DA, Fry GL, Waknitz MA, Iverius PH, Williams SE, Strickland DK (Dec 1992).
3820:
3223:
2682:
2370:
7768:
7463:
7296:
6604:
6594:
6125:
6091:
4069:
3942:
Gordts PL, Reekmans S, Lauwers A, Van Dongen A, Verbeek L, Roebroek AJ (Sep 2009).
2005:
1964:
1870:
1846:
1742:
1527:
413:
192:
4083:
Boucher P, Li WP, Matz RL, Takayama Y, Auwerx J, Anderson RG, et al. (2007).
1616:
domain. The extracellular domain of LRP1 is the alpha-chain, which comprises four
155:
4849:
Zhuo M, Holtzman DM, Li Y, Osaka H, DeMaro J, Jacquin M, et al. (Jan 2000).
4149:
Yancey PG, Ding Y, Fan D, Blakemore JL, Zhang Y, Ding L, et al. (Jul 2011).
4109:
3834:
Bachmeier C, Shackleton B, Ojo J, Paris D, Mullan M, Crawford F (December 2014).
3563:
3319:
179:
7478:
7467:
7451:
7442:
7306:
6955:
6733:
6708:
6407:
6029:
5955:
5429:
3546:
Liu Q, Zerbinatti CV, Zhang J, Hoe HS, Wang B, Cole SL, et al. (Oct 2007).
3446:
Liu Q, Zhang J, Tran H, Verbeek MM, Reiss K, Estus S, et al. (April 2009).
2881:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2863:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2227:
2179:
2125:
2071:
2065:
2017:
1882:
1815:
1754:
1734:
1715:
1705:
1666:
1640:
1613:
1546:
1531:
4904:
Proceedings of the
National Academy of Sciences of the United States of America
4313:
Proceedings of the
National Academy of Sciences of the United States of America
3960:
3943:
3889:
Proceedings of the
National Academy of Sciences of the United States of America
3612:
3499:"tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis"
496:
7236:
6960:
6641:
6382:
6258:
5891:
5886:
5881:
5736:
5520:
3851:
3836:"Apolipoprotein E isoform-specific effects on lipoprotein receptor processing"
3359:
2355:
Click on genes, proteins and metabolites below to link to respective articles.
2077:
1913:
levels and, consequently, tumor progression. Alternatively, LRP1 may regulate
1906:
1794:
1708:
1693:
1643:
1605:
1549:
312:
209:
159:
4257:
4240:
3265:
1769:
for degradation. In lipoprotein metabolism, the interaction between LRP1 and
7075:
7070:
7065:
7055:
7050:
7045:
7040:
4924:
4777:
4760:
4333:
4053:
3909:
3646:"Endothelial LRP1 transports amyloid-β(1-42) across the blood-brain barrier"
2894:
Herz J, Hamann U, Rogne S, Myklebost O, Gausepohl H, Stanley KK (Dec 1988).
2275:
2059:
2029:
1986:
1930:
1746:
1662:
1596:, resulting in a 515 kDa alpha-chain and an 85 kDa beta-chain associated non
1169:
556:
434:
379:
366:
278:
265:
167:
5216:
5173:
5138:
5095:
5060:
5031:
4992:
4884:
4817:
4737:
4701:
4692:
4675:
4660:
4651:
4634:
4496:
4455:
4446:
4429:
4401:
4225:
4184:
4128:
4061:
3969:
3928:
3869:
3812:
3777:
3728:
3679:
3630:
3581:
3532:
3514:
3483:
3464:
3432:
3378:
3327:
3283:
3215:
3071:
1681:
LRP1 is a member of the LDLR family and ubiquitously expressed in multiple
4974:
4943:
4835:
4786:
4619:
4578:
4537:
4383:
4352:
4266:
4018:
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to function. Cholesterol is imported into the neuron by apolipoprotein E (
1471:
7381:
7281:
7095:
7080:
6283:
6278:
6186:
5876:
4293:
3413:
2981:
2281:
2149:
2143:
2119:
2053:
1766:
1723:
1712:
1686:
1655:
1629:
1455:
1314:
1295:
950:
protein kinase C-activating G protein-coupled receptor signaling pathway
7331:
7326:
7321:
7221:
7035:
7025:
6852:
6831:
6826:
6794:
6599:
6519:
6514:
6509:
6504:
6499:
6417:
6110:
5950:
5945:
5940:
5935:
5930:
5401:
2269:
2221:
2215:
2155:
1894:
1762:
1750:
1557:
1515:
1281:
1236:
1130:
positive regulation of vascular associated smooth muscle cell migration
5300:: LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN COMPLEMENT REPEAT 8
5164:
5147:
4729:
3804:
2982:"Entrez Gene: LRP1 low density lipoprotein receptor-related protein 1"
1781:
activity, inhibited SMC migration, and ultimately, protection against
1466:
100:
96:
92:
88:
84:
80:
76:
7692:
7627:
7271:
7231:
7216:
7200:
7195:
7175:
7170:
7105:
6913:
6883:
6847:
6838:
6651:
6619:
6483:
6478:
6448:
6427:
6387:
6347:
6213:
6191:
6150:
6074:
6069:
6064:
6059:
6054:
6049:
5918:
5913:
5908:
5856:
5841:
5711:
5701:
5664:
5659:
5577:
5572:
3759:
3710:
3661:
3497:
Hu K, Lin L, Tan X, Yang J, Bu G, Mars WM, et al. (March 2008).
2191:
1938:
1910:
1874:
1842:
1838:
soluble LRP1 which is no longer able to transcytose the Aβ peptides.
1811:
1726:
maturation and recycling, regulation of vascular tone, regulation of
1697:
1647:
1617:
1569:
1545:
protein and, thus, involved in various biological processes, such as
1439:
1191:
4000:
1773:
stimulates a signaling pathway that leads to elevated intracellular
1845:
in the brain is associated with reduced LRP1 mediated clearance of
7803:
7798:
7793:
7755:
7750:
7710:
7557:
7552:
7547:
7438:
7396:
7371:
7291:
7286:
7276:
7266:
7251:
7246:
7241:
7226:
7180:
7165:
7130:
7115:
7110:
7100:
7020:
7015:
7010:
6989:
6985:
6975:
6888:
6789:
6784:
6743:
6693:
6688:
6683:
6678:
6663:
6656:
6636:
6624:
6567:
6562:
6557:
6547:
6542:
6535:
6473:
6463:
6458:
6453:
6443:
6422:
6412:
6377:
6372:
6367:
6362:
6357:
6312:
6307:
6273:
6238:
6233:
6228:
6218:
6206:
6201:
6181:
6176:
6171:
6166:
6120:
6012:
6007:
5826:
5810:
5803:
5798:
5793:
5788:
5783:
5778:
5753:
5731:
5726:
5619:
5545:
5540:
5530:
2311:
2305:
2299:
2251:
2203:
2197:
2185:
2161:
2101:
2097:
2083:
1974:
1926:
1701:
1589:
5023:
1154:
1150:
7740:
7730:
7720:
7715:
7391:
7386:
7376:
7366:
7361:
7356:
7311:
7301:
7261:
7190:
7160:
7155:
7150:
7145:
7140:
7135:
7090:
7060:
6965:
6933:
6928:
6908:
6898:
6893:
6878:
6873:
6774:
6769:
6738:
6718:
6713:
6703:
6698:
6577:
6530:
6490:
6145:
6140:
6135:
6130:
6115:
6101:
6096:
6081:
6039:
6034:
6024:
6019:
6002:
5997:
5992:
5987:
5982:
5977:
5972:
5967:
5962:
5898:
5871:
5866:
5861:
5836:
5831:
5768:
5763:
5758:
5748:
5743:
5696:
5691:
5686:
5676:
5671:
5654:
5649:
5644:
5634:
5629:
5614:
5609:
5604:
5594:
5589:
5584:
5567:
5562:
5557:
5508:
5476:
5471:
5466:
5449:
5444:
5439:
5434:
4898:
Orth K, Madison EL, Gething MJ, Sambrook JF, Herz J (Aug 1992).
4800:
Godyna S, Liau G, Popa I, Stefansson S, Argraves WS (Jun 1995).
4198:
Overton CD, Yancey PG, Major AS, Linton MF, Fazio S (Mar 2007).
2341:
2257:
2209:
2173:
2167:
2093:
2047:
2041:
2011:
1898:
1819:
1601:
1538:
147:
7411:
5374:
5253:
1789:
LRP1 performs endocytic clearance of proteases and inhibitors,
594:
6903:
5515:
5503:
5498:
5493:
5483:
5456:
5424:
5249:
4307:
Kowal RC, Herz J, Goldstein JL, Esser V, Brown MS (Aug 1989).
3036:"LRP-1: a checkpoint for the extracellular matrix proteolysis"
1992:
1922:
1115:
positive regulation of protein localization to plasma membrane
1055:
positive regulation of axon extension involved in regeneration
1604:
family, LRP1 contains cysteine-rich complement-type repeats,
5345:: NMR Solution structure of calcium-loaded LRP double module
3308:
2681:
2369:
4957:
Czekay RP, Kuemmel TA, Orlando RA, Farquhar MG (May 2001).
4469:
Basu S, Binder RJ, Ramalingam T, Srivastava PK (Mar 2001).
2772:
The interactive pathway map can be edited at WikiPathways:
1651:
1060:
positive regulation of collateral sprouting of injured axon
3448:"LRP1 shedding in human brain: roles of ADAM10 and ADAM17"
1135:
positive regulation of lysosomal protein catabolic process
1070:
negative regulation of cytosolic calcium ion concentration
995:
positive regulation of cytosolic calcium ion concentration
5330:: Crystal structure of ligand-binding repeat CR7 from LRP
1925:
pathways to aid invasion. Moreover, LRP1 interacts with
403:
4239:
Trommsdorff M, Borg JP, Margolis B, Herz J (Dec 1998).
3983:
Rohlmann A, Gotthardt M, Hammer RE, Herz J (Feb 1998).
3595:
Deane R, Bell RD, Sagare A, Zlokovic BV (March 2009).
3341:
Shackleton B, Crawford F, Bachmeier C (August 2016).
568:
5189:
Lillis AP, Mikhailenko I, Strickland DK (Aug 2005).
3188:
Lillis AP, Mikhailenko I, Strickland DK (Aug 2005).
1100:
amyloid-beta clearance by cellular catabolic process
1010:
positive regulation of neuron projection development
870:
negative regulation of neuron projection development
7782:
7682:
7654:
7625:
7530:
7450:
7209:
7003:
6752:
6436:
6159:
5819:
5417:
5070:"LDL receptor-related proteins in neurodevelopment"
4633:Barnes H, Ackermann EJ, van der Geer P (Jun 2003).
1400:
1379:
1353:
1332:
905:
negative regulation of smooth muscle cell migration
5117:Arteriosclerosis, Thrombosis, and Vascular Biology
3948:Arteriosclerosis, Thrombosis, and Vascular Biology
3034:Etique N, Verzeaux L, Dedieu S, Emonard H (2013).
2837:
2835:
2833:
2816:
2814:
2812:
1484:Low density lipoprotein receptor-related protein 1
663:low-density lipoprotein particle receptor activity
350:
249:
1534:. In humans, the LRP1 protein is encoded by the
980:astrocyte activation involved in immune response
4423:
4421:
4419:
4417:
4415:
4413:
4411:
3301:
3299:
3297:
3295:
3293:
3243:
3241:
3239:
3237:
3235:
3233:
3183:
3181:
3179:
3177:
3175:
3173:
3171:
3169:
3167:
3165:
3163:
3161:
3159:
3157:
3155:
3153:
3151:
3149:
3147:
3145:
3143:
3141:
3139:
3137:
3135:
3133:
3131:
3129:
3127:
3125:
3123:
3121:
3119:
3117:
3115:
3113:
3111:
3109:
3107:
3105:
3103:
3101:
3029:
3027:
3025:
3023:
3021:
3019:
3017:
3015:
3013:
3011:
2685:
2373:
860:negative regulation of neuron apoptotic process
3099:
3097:
3095:
3093:
3091:
3089:
3087:
3085:
3083:
3081:
3009:
3007:
3005:
3003:
3001:
2999:
2997:
2995:
2993:
2991:
2842:GRCm38: Ensembl release 89: ENSMUSG00000040249
1075:negative regulation of focal adhesion assembly
1000:negative regulation of cell-substrate adhesion
975:regulation of extracellular matrix disassembly
7423:
5386:
5265:
3601:CNS & Neurological Disorders Drug Targets
3503:Journal of the American Society of Nephrology
1110:positive regulation of amyloid-beta clearance
1105:positive regulation of Schwann cell migration
880:regulation of actin cytoskeleton organization
8:
2798:Low density lipoprotein receptor gene family
1090:positive regulation of ERK1 and ERK2 cascade
895:negative regulation of Wnt signaling pathway
2821:GRCh38: Ensembl release 89: ENSG00000123384
7430:
7416:
7408:
5393:
5379:
5371:
5272:
5258:
5250:
1165:
610:
391:
290:
187:
65:
5410:list of human clusters of differentiation
5242:at the U.S. National Library of Medicine
5206:
5163:
5128:
5111:Llorente-Cortés V, Badimon L (Mar 2005).
5085:
4982:
4933:
4923:
4874:
4825:
4776:
4691:
4650:
4609:
4568:
4527:
4486:
4445:
4391:
4342:
4332:
4256:
4215:
4174:
4118:
4108:
4008:
3959:
3918:
3908:
3859:
3767:
3718:
3669:
3620:
3571:
3522:
3473:
3463:
3422:
3412:
3368:
3358:
3273:
3205:
3061:
3051:
2919:
1120:positive regulation of cholesterol import
955:positive regulation of cholesterol efflux
5148:"TGF-beta control of cell proliferation"
2976:
2974:
1917:disassembly of cancer cells through the
1030:negative regulation of apoptotic process
935:positive regulation of protein transport
5287:
2808:
2765:
1720:platelet derived growth factor receptor
885:regulation of phospholipase A2 activity
688:alpha-2 macroglobulin receptor activity
16:Mammalian protein found in Homo sapiens
1095:amyloid-beta clearance by transcytosis
1020:positive regulation of protein binding
910:positive regulation of lipid transport
20:
5195:Journal of Thrombosis and Haemostasis
3989:The Journal of Clinical Investigation
3748:The Journal of Clinical Investigation
3699:The Journal of Clinical Investigation
3650:The Journal of Clinical Investigation
3390:
3388:
3194:Journal of Thrombosis and Haemostasis
1905:, which contributes to prevention of
1045:positive regulation of axon extension
764:integral component of plasma membrane
638:lipoprotein particle receptor binding
355:
316:
311:
254:
213:
208:
7:
5087:10.1034/j.1600-0854.2003.00086_4_5.x
1899:urokinase-type plasminogen activator
713:heparan sulfate proteoglycan binding
4765:The Journal of Biological Chemistry
4680:The Journal of Biological Chemistry
4598:The Journal of Biological Chemistry
4557:The Journal of Biological Chemistry
4516:The Journal of Biological Chemistry
4434:The Journal of Biological Chemistry
4245:The Journal of Biological Chemistry
1065:positive regulation of phagocytosis
930:regulation of cholesterol transport
5130:10.1161/01.ATV.0000154280.62072.fd
4867:10.1523/JNEUROSCI.20-02-00542.2000
4217:10.1161/01.RES.0000260204.40510.aa
2912:10.1002/j.1460-2075.1988.tb03306.x
1841:In addition, over-accumulation of
1397:
1376:
1350:
1329:
1305:
1286:
1260:
1241:
1215:
1196:
1050:positive regulation of endocytosis
945:multicellular organism development
643:protein-containing complex binding
573:
535:choroid plexus of fourth ventricle
491:
429:
408:
14:
5041:Trends in Cardiovascular Medicine
4167:10.1161/CIRCULATIONAHA.111.032268
1639:, and other proteins involved in
1125:cellular response to amyloid-beta
1080:negative regulation of cell death
1005:positive regulation of cell death
7521:
5350:
5335:
5320:
5305:
5290:
5208:10.1111/j.1538-7836.2005.01371.x
5152:Journal of Cellular Biochemistry
4718:Journal of Cellular Biochemistry
4134:
3207:10.1111/j.1538-7836.2005.01371.x
1685:, though it is most abundant in
1608:repeats, β-propeller domains, a
1035:cellular lipid catabolic process
693:apolipoprotein receptor activity
584:
577:
339:
332:
326:
303:
238:
231:
225:
200:
29:
5146:Huang SS, Huang JS (Oct 2005).
2318:Tissue factor pathway inhibitor
839:plasma membrane protein complex
3347:Fluids and Barriers of the CNS
2264:Sphingolipid activator protein
1530:involved in receptor-mediated
1492:alpha-2-macroglobulin receptor
824:insulin-responsive compartment
729:integral component of membrane
595:More reference expression data
557:More reference expression data
1:
5053:10.1016/S1050-1738(02)00154-8
4963:Molecular Biology of the Cell
4611:10.1016/S0021-9258(18)35675-8
4570:10.1016/S0021-9258(18)31759-9
4529:10.1016/S0021-9258(17)37017-5
4488:10.1016/s1074-7613(01)00111-x
3040:BioMed Research International
1508:cluster of differentiation 91
965:cell population proliferation
915:receptor-mediated endocytosis
855:lipoprotein metabolic process
324:
223:
7825:Genes on human chromosome 12
4110:10.1371/journal.pone.0000448
3564:10.1016/j.neuron.2007.08.008
3320:10.1016/j.biocel.2014.04.021
2957:10.1016/0888-7543(89)90087-6
2330:Transforming growth factor-β
698:clathrin heavy chain binding
7830:Clusters of differentiation
5406:clusters of differentiation
4855:The Journal of Neuroscience
4806:The Journal of Cell Biology
4372:The Journal of Cell Biology
3793:Neuro-Degenerative Diseases
3452:Molecular Neurodegeneration
1654:conditions, such as inside
960:cerebral cortex development
819:basolateral plasma membrane
703:signaling receptor activity
678:scavenger receptor activity
445:stromal cell of endometrium
7848:
5068:May P, Herz J (May 2003).
3961:10.1161/ATVBAHA.109.192211
3613:10.2174/187152709787601867
2793:Cluster of differentiation
1759:integral membrane proteins
1562:neurodegenerative diseases
1432:Chr 10: 127.37 – 127.46 Mb
925:retinoid metabolic process
734:endocytic vesicle membrane
7519:
5285:
3852:10.1007/s12017-014-8318-6
3360:10.1186/s12987-016-0038-x
2877:"Mouse PubMed Reference:"
2859:"Human PubMed Reference:"
1969:amyloid precursor protein
1857:to Alzheimer's disease.
1761:or adaptor proteins like
1500:apolipoprotein E receptor
1470:
1465:
1461:
1454:
1438:
1419:
1404:
1383:
1372:
1357:
1336:
1325:
1312:
1308:
1293:
1289:
1280:
1267:
1263:
1248:
1244:
1235:
1222:
1218:
1203:
1199:
1190:
1175:
1168:
1164:
1148:
613:
609:
592:
576:
567:
554:
503:
494:
449:Descending thoracic aorta
441:
432:
402:
394:
390:
373:
360:
323:
302:
293:
289:
272:
259:
222:
199:
190:
186:
141:
138:
128:
121:
116:
73:
68:
51:
46:
41:
37:
28:
23:
5244:Medical Subject Headings
4280:Poswa M (Mar 1977). "".
4258:10.1074/jbc.273.50.33556
3266:10.18632/oncotarget.4640
2024:Circumsporozoite protein
1855:is thought to contribute
1425:Chr 12: 57.13 – 57.21 Mb
1015:receptor internalization
940:apoptotic cell clearance
7656:Lipid transfer proteins
5012:Frontiers in Bioscience
4925:10.1073/pnas.89.16.7422
4778:10.1074/jbc.272.10.6784
4334:10.1073/pnas.86.15.5810
4054:10.1126/science.1082095
3910:10.1073/pnas.1302212110
3840:Neuromolecular Medicine
2350:Interactive pathway map
1949:LRP1 has been shown to
1933:(MCs) and induce their
1806:
1584:gene encodes a 600 kDa
1085:chemoattraction of axon
794:clathrin-coated vesicle
708:cargo receptor activity
519:external carotid artery
515:internal carotid artery
7684:Cell surface receptors
4818:10.1083/jcb.129.5.1403
4693:10.1074/jbc.M200427200
4652:10.1038/sj.onc.1206504
4447:10.1074/jbc.M000955200
3515:10.1681/ASN.2007030300
3465:10.1186/1750-1326-4-17
2775:"Statin_Pathway_WP430"
2737:
2425:
1861:Cardiovascular disease
1757:, in conjunction with
890:amyloid-beta clearance
633:apolipoprotein binding
511:superior frontal gyrus
4975:10.1091/mbc.12.5.1467
4384:10.1083/jcb.200302069
2736:
2424:
1802:Clinical significance
1600:. As a member of the
1588:that is processed by
1541:. LRP1 is also a key
970:lipoprotein transport
527:primary visual cortex
507:stroma of bone marrow
465:right coronary artery
318:Chromosome 10 (mouse)
216:Chromosome 12 (human)
7786:cassette transporter
4204:Circulation Research
3414:10.1096/fj.10-169508
2743:|alt=Statin pathway
2240:Pseudomonas exotoxin
1791:proteolytic cleavage
1622:extracellular matrix
673:amyloid-beta binding
481:left coronary artery
69:List of PDB id codes
42:Available structures
7513:Remnant cholesterol
7445:particle metabolism
4916:1992PNAS...89.7422O
4325:1989PNAS...86.5810K
4282:Quintessenz Journal
4101:2007PLoSO...2..448B
4046:2003Sci...300..329B
3901:2013PNAS..11014771S
3053:10.1155/2013/152163
2234:Protein C inhibitor
2108:heparin cofactor II
2090:Heat shock proteins
1881:. Finally, LRP1 in
1879:smooth muscle cells
1851:blood brain barrier
1831:blood-brain barrier
1807:Alzheimer's disease
1728:blood brain barrier
1690:smooth muscle cells
1671:signal transduction
1140:lysosomal transport
920:aorta morphogenesis
834:apical part of cell
789:clathrin-coated pit
683:coreceptor activity
628:calcium ion binding
473:canal of the cervix
2738:
2426:
2132:Lipoprotein lipase
1903:metalloproteinases
1777:levels, increased
1634:protease inhibitor
1270:ENSMUSG00000040249
848:Biological process
829:axonal growth cone
774:neuronal cell body
769:lysosomal membrane
722:Cellular component
621:Molecular function
7812:
7811:
7405:
7404:
5368:
5367:
5165:10.1002/jcb.20558
4730:10.1002/jcb.10781
4686:(18): 15499–506.
3805:10.1159/000337231
3754:(12): 1489–1499.
1586:precursor protein
1490:), also known as
1481:
1480:
1477:
1476:
1450:
1449:
1415:
1414:
1394:
1393:
1368:
1367:
1347:
1346:
1321:
1320:
1302:
1301:
1276:
1275:
1257:
1256:
1231:
1230:
1212:
1211:
1160:
1159:
648:metal ion binding
605:
604:
601:
600:
563:
562:
550:
549:
543:perirhinal cortex
539:cerebellar cortex
488:
487:
386:
385:
285:
284:
112:
111:
108:
107:
52:Ortholog search:
7837:
7525:
7454:particle classes
7432:
7425:
7418:
7409:
5395:
5388:
5381:
5372:
5354:
5339:
5324:
5309:
5294:
5274:
5267:
5260:
5251:
5228:
5210:
5185:
5167:
5142:
5132:
5107:
5089:
5064:
5035:
4997:
4996:
4986:
4954:
4948:
4947:
4937:
4927:
4895:
4889:
4888:
4878:
4846:
4840:
4839:
4829:
4797:
4791:
4790:
4780:
4756:
4750:
4749:
4712:
4706:
4705:
4695:
4671:
4665:
4664:
4654:
4630:
4624:
4623:
4613:
4589:
4583:
4582:
4572:
4563:(50): 31747–55.
4548:
4542:
4541:
4531:
4507:
4501:
4500:
4490:
4466:
4460:
4459:
4449:
4440:(33): 25616–24.
4425:
4406:
4405:
4395:
4363:
4357:
4356:
4346:
4336:
4304:
4298:
4297:
4277:
4271:
4270:
4260:
4251:(50): 33556–60.
4236:
4230:
4229:
4219:
4195:
4189:
4188:
4178:
4146:
4140:
4139:
4138:
4132:
4122:
4112:
4080:
4074:
4073:
4040:(5617): 329–32.
4029:
4023:
4022:
4012:
3980:
3974:
3973:
3963:
3939:
3933:
3932:
3922:
3912:
3880:
3874:
3873:
3863:
3831:
3825:
3824:
3788:
3782:
3781:
3771:
3760:10.1172/JCI10498
3739:
3733:
3732:
3722:
3711:10.1172/JCI11013
3705:(9): 1159–1166.
3690:
3684:
3683:
3673:
3662:10.1172/JCI81108
3641:
3635:
3634:
3624:
3592:
3586:
3585:
3575:
3543:
3537:
3536:
3526:
3494:
3488:
3487:
3477:
3467:
3443:
3437:
3436:
3426:
3416:
3407:(8): 2770–2781.
3392:
3383:
3382:
3372:
3362:
3338:
3332:
3331:
3303:
3288:
3287:
3277:
3260:(27): 23647–61.
3245:
3228:
3227:
3209:
3185:
3076:
3075:
3065:
3055:
3031:
2986:
2985:
2978:
2969:
2968:
2940:
2934:
2933:
2923:
2900:The EMBO Journal
2891:
2885:
2884:
2873:
2867:
2866:
2855:
2849:
2839:
2828:
2818:
2779:
2778:
2770:
2677:
2672:
2667:
2662:
2657:
2652:
2647:
2642:
2637:
2632:
2627:
2622:
2617:
2612:
2607:
2602:
2597:
2592:
2587:
2582:
2577:
2572:
2567:
2562:
2557:
2552:
2547:
2542:
2537:
2532:
2527:
2522:
2517:
2512:
2507:
2502:
2497:
2492:
2487:
2482:
2477:
2472:
2467:
2462:
2457:
2452:
2447:
2442:
2437:
2432:
2294:Thrombospondin 2
1959:A2-Macroglobulin
1783:vascular disease
1779:protein kinase A
1463:
1462:
1434:
1427:
1410:
1398:
1389:
1377:
1373:RefSeq (protein)
1363:
1351:
1342:
1330:
1306:
1287:
1261:
1242:
1216:
1197:
1166:
985:lipid metabolism
754:receptor complex
653:protease binding
611:
597:
588:
581:
574:
559:
499:
497:Top expressed in
492:
437:
435:Top expressed in
430:
409:
392:
382:
369:
358:
343:
336:
330:
319:
307:
291:
281:
268:
257:
242:
235:
229:
218:
204:
188:
182:
180:LRP1 - orthologs
133:
126:
103:
66:
60:
39:
38:
33:
21:
7847:
7846:
7840:
7839:
7838:
7836:
7835:
7834:
7815:
7814:
7813:
7808:
7785:
7778:
7678:
7650:
7621:
7532:Apolipoproteins
7526:
7517:
7455:
7446:
7436:
7406:
7401:
7205:
6999:
6748:
6432:
6155:
5815:
5413:
5399:
5369:
5364:
5361:
5355:
5346:
5340:
5331:
5325:
5316:
5310:
5301:
5295:
5281:
5278:
5236:
5231:
5188:
5145:
5110:
5067:
5038:
5009:
5005:
5003:Further reading
5000:
4956:
4955:
4951:
4897:
4896:
4892:
4848:
4847:
4843:
4799:
4798:
4794:
4771:(10): 6784–91.
4758:
4757:
4753:
4714:
4713:
4709:
4673:
4672:
4668:
4645:(23): 3589–97.
4632:
4631:
4627:
4604:(36): 25764–7.
4591:
4590:
4586:
4550:
4549:
4545:
4509:
4508:
4504:
4468:
4467:
4463:
4427:
4426:
4409:
4365:
4364:
4360:
4306:
4305:
4301:
4279:
4278:
4274:
4238:
4237:
4233:
4197:
4196:
4192:
4148:
4147:
4143:
4133:
4082:
4081:
4077:
4031:
4030:
4026:
4001:10.1172/JCI1240
3982:
3981:
3977:
3941:
3940:
3936:
3895:(36): 14771–6.
3882:
3881:
3877:
3833:
3832:
3828:
3790:
3789:
3785:
3741:
3740:
3736:
3692:
3691:
3687:
3643:
3642:
3638:
3594:
3593:
3589:
3545:
3544:
3540:
3496:
3495:
3491:
3445:
3444:
3440:
3394:
3393:
3386:
3340:
3339:
3335:
3305:
3304:
3291:
3247:
3246:
3231:
3187:
3186:
3079:
3033:
3032:
2989:
2980:
2979:
2972:
2942:
2941:
2937:
2906:(13): 4119–27.
2893:
2892:
2888:
2875:
2874:
2870:
2857:
2856:
2852:
2840:
2831:
2819:
2810:
2806:
2789:
2784:
2783:
2782:
2773:
2771:
2767:
2762:
2761:
2760:
2756:Statin pathway
2755:
2750:
2749:
2748:
2742:
2741:
2740:
2739:
2735:
2679:
2678:
2675:
2673:
2670:
2668:
2665:
2663:
2660:
2658:
2655:
2653:
2650:
2648:
2645:
2643:
2640:
2638:
2635:
2633:
2630:
2628:
2625:
2623:
2620:
2618:
2615:
2613:
2610:
2608:
2605:
2603:
2600:
2598:
2595:
2593:
2590:
2588:
2585:
2583:
2580:
2578:
2575:
2573:
2570:
2568:
2565:
2563:
2560:
2558:
2555:
2553:
2550:
2548:
2545:
2543:
2540:
2538:
2535:
2533:
2530:
2528:
2525:
2523:
2520:
2518:
2515:
2513:
2510:
2508:
2505:
2503:
2500:
2498:
2495:
2493:
2490:
2488:
2485:
2483:
2480:
2478:
2475:
2473:
2470:
2468:
2465:
2463:
2460:
2458:
2455:
2453:
2450:
2448:
2445:
2443:
2440:
2438:
2435:
2433:
2430:
2427:
2423:
2352:
2347:
1947:
1907:cancer invasion
1891:
1867:Atherosclerosis
1863:
1809:
1804:
1679:
1578:
1566:atherosclerosis
1524:plasma membrane
1472:View/Edit Mouse
1467:View/Edit Human
1430:
1423:
1420:Location (UCSC)
1406:
1385:
1359:
1338:
1251:ENSG00000123384
1144:
843:
759:plasma membrane
717:
658:protein binding
593:
583:
582:
555:
546:
541:
537:
533:
529:
525:
521:
517:
513:
509:
495:
484:
479:
475:
471:
467:
463:
459:
455:
453:ascending aorta
451:
447:
433:
377:
364:
356:
346:
345:
344:
337:
317:
294:Gene location (
276:
263:
255:
245:
244:
243:
236:
214:
191:Gene location (
142:
129:
122:
75:
53:
17:
12:
11:
5:
7845:
7844:
7841:
7833:
7832:
7827:
7817:
7816:
7810:
7809:
7807:
7806:
7801:
7796:
7790:
7788:
7780:
7779:
7777:
7776:
7771:
7765:
7764:
7763:
7758:
7753:
7748:
7743:
7738:
7733:
7728:
7723:
7718:
7713:
7708:
7696:
7695:
7688:
7686:
7680:
7679:
7677:
7676:
7671:
7666:
7660:
7658:
7652:
7651:
7649:
7648:
7643:
7638:
7632:
7630:
7626:Extracellular
7623:
7622:
7620:
7619:
7618:
7617:
7607:
7602:
7597:
7592:
7591:
7590:
7585:
7580:
7575:
7567:
7562:
7561:
7560:
7555:
7550:
7545:
7536:
7534:
7528:
7527:
7520:
7518:
7516:
7515:
7510:
7505:
7500:
7497:
7494:
7489:
7475:
7470:
7459:
7457:
7456:and subclasses
7448:
7447:
7437:
7435:
7434:
7427:
7420:
7412:
7403:
7402:
7400:
7399:
7394:
7389:
7384:
7379:
7374:
7369:
7364:
7359:
7354:
7349:
7344:
7339:
7334:
7329:
7324:
7319:
7314:
7309:
7304:
7299:
7294:
7289:
7284:
7279:
7274:
7269:
7264:
7259:
7254:
7249:
7244:
7239:
7234:
7229:
7224:
7219:
7213:
7211:
7207:
7206:
7204:
7203:
7198:
7193:
7188:
7183:
7178:
7173:
7168:
7163:
7158:
7153:
7148:
7143:
7138:
7133:
7128:
7123:
7118:
7113:
7108:
7103:
7098:
7093:
7088:
7083:
7078:
7073:
7068:
7063:
7058:
7053:
7048:
7043:
7038:
7033:
7028:
7023:
7018:
7013:
7007:
7005:
7001:
7000:
6998:
6997:
6992:
6983:
6978:
6973:
6968:
6963:
6958:
6953:
6948:
6943:
6938:
6937:
6936:
6931:
6921:
6916:
6911:
6906:
6901:
6896:
6891:
6886:
6881:
6876:
6871:
6866:
6861:
6856:
6850:
6841:
6836:
6835:
6834:
6829:
6819:
6814:
6813:
6812:
6807:
6797:
6792:
6787:
6782:
6777:
6772:
6767:
6762:
6756:
6754:
6750:
6749:
6747:
6746:
6741:
6736:
6731:
6726:
6721:
6716:
6711:
6706:
6701:
6696:
6691:
6686:
6681:
6676:
6671:
6666:
6661:
6660:
6659:
6654:
6644:
6639:
6634:
6629:
6628:
6627:
6622:
6617:
6607:
6602:
6597:
6592:
6587:
6586:
6585:
6580:
6570:
6565:
6560:
6555:
6550:
6545:
6540:
6539:
6538:
6533:
6523:
6517:
6512:
6507:
6502:
6493:
6488:
6487:
6486:
6481:
6476:
6466:
6461:
6456:
6451:
6446:
6440:
6438:
6434:
6433:
6431:
6430:
6425:
6420:
6415:
6410:
6405:
6400:
6395:
6390:
6385:
6380:
6375:
6370:
6365:
6360:
6355:
6350:
6345:
6340:
6335:
6330:
6325:
6320:
6315:
6310:
6305:
6304:
6303:
6298:
6288:
6287:
6286:
6281:
6271:
6266:
6261:
6256:
6251:
6246:
6241:
6236:
6231:
6226:
6221:
6216:
6211:
6210:
6209:
6204:
6194:
6189:
6184:
6179:
6174:
6169:
6163:
6161:
6157:
6156:
6154:
6153:
6148:
6143:
6138:
6133:
6128:
6123:
6118:
6113:
6104:
6099:
6094:
6089:
6084:
6079:
6078:
6077:
6072:
6067:
6062:
6057:
6052:
6042:
6037:
6032:
6027:
6022:
6017:
6016:
6015:
6010:
6000:
5995:
5990:
5985:
5980:
5975:
5970:
5965:
5960:
5959:
5958:
5953:
5948:
5943:
5938:
5933:
5923:
5922:
5921:
5916:
5911:
5901:
5896:
5895:
5894:
5889:
5884:
5874:
5869:
5864:
5859:
5854:
5849:
5844:
5839:
5834:
5829:
5823:
5821:
5817:
5816:
5814:
5813:
5808:
5807:
5806:
5801:
5796:
5791:
5786:
5781:
5771:
5766:
5761:
5756:
5751:
5746:
5741:
5740:
5739:
5734:
5729:
5724:
5714:
5709:
5704:
5699:
5694:
5689:
5684:
5679:
5674:
5669:
5668:
5667:
5662:
5652:
5647:
5642:
5637:
5632:
5627:
5622:
5617:
5612:
5607:
5602:
5597:
5592:
5587:
5582:
5581:
5580:
5575:
5565:
5560:
5555:
5550:
5549:
5548:
5543:
5538:
5533:
5523:
5518:
5513:
5512:
5511:
5501:
5496:
5491:
5486:
5481:
5480:
5479:
5474:
5469:
5459:
5454:
5453:
5452:
5447:
5442:
5437:
5432:
5421:
5419:
5415:
5414:
5400:
5398:
5397:
5390:
5383:
5375:
5366:
5365:
5363:
5362:
5356:
5349:
5347:
5341:
5334:
5332:
5326:
5319:
5317:
5311:
5304:
5302:
5296:
5289:
5286:
5283:
5282:
5279:
5277:
5276:
5269:
5262:
5254:
5248:
5247:
5235:
5234:External links
5232:
5230:
5229:
5201:(8): 1884–93.
5186:
5143:
5123:(3): 497–504.
5108:
5080:(5): 291–301.
5065:
5036:
5018:(4): d731–51.
5006:
5004:
5001:
4999:
4998:
4969:(5): 1467–79.
4949:
4910:(16): 7422–6.
4890:
4841:
4812:(5): 1403–10.
4792:
4751:
4707:
4666:
4625:
4584:
4543:
4522:(12): 8653–8.
4502:
4461:
4407:
4378:(6): 1179–89.
4358:
4319:(15): 5810–4.
4299:
4272:
4231:
4190:
4141:
4075:
4024:
3975:
3954:(9): 1258–64.
3934:
3875:
3846:(4): 686–696.
3826:
3783:
3734:
3685:
3656:(1): 123–136.
3636:
3587:
3538:
3509:(3): 503–514.
3489:
3438:
3384:
3333:
3289:
3229:
3200:(8): 1884–93.
3077:
2987:
2970:
2935:
2886:
2868:
2850:
2829:
2807:
2805:
2802:
2801:
2800:
2795:
2788:
2785:
2781:
2780:
2764:
2763:
2752:
2751:
2680:
2674:
2669:
2664:
2659:
2654:
2649:
2644:
2639:
2634:
2629:
2624:
2619:
2614:
2609:
2604:
2599:
2594:
2589:
2584:
2579:
2574:
2569:
2564:
2559:
2554:
2549:
2544:
2539:
2534:
2529:
2524:
2519:
2514:
2509:
2504:
2499:
2494:
2489:
2484:
2479:
2474:
2469:
2464:
2459:
2454:
2449:
2444:
2439:
2434:
2429:
2428:
2368:
2367:
2366:
2365:
2363:
2362:
2361:
2360:
2359:
2358:
2351:
2348:
2346:
2345:
2339:
2333:
2327:
2321:
2315:
2309:
2303:
2297:
2291:
2285:
2279:
2273:
2267:
2261:
2255:
2249:
2243:
2237:
2231:
2225:
2219:
2213:
2207:
2201:
2195:
2189:
2183:
2177:
2171:
2165:
2159:
2153:
2147:
2141:
2135:
2129:
2123:
2117:
2114:Hepatic lipase
2111:
2105:
2087:
2081:
2075:
2069:
2063:
2057:
2051:
2045:
2039:
2033:
2027:
2021:
2015:
2009:
2003:
1990:
1984:
1978:
1972:
1962:
1955:
1946:
1943:
1915:focal adhesion
1890:
1887:
1862:
1859:
1808:
1805:
1803:
1800:
1787:membrane-bound
1739:cell migration
1678:
1675:
1626:growth factors
1612:domain, and a
1577:
1574:
1479:
1478:
1475:
1474:
1469:
1459:
1458:
1452:
1451:
1448:
1447:
1445:
1443:
1436:
1435:
1428:
1421:
1417:
1416:
1413:
1412:
1402:
1401:
1395:
1392:
1391:
1381:
1380:
1374:
1370:
1369:
1366:
1365:
1355:
1354:
1348:
1345:
1344:
1334:
1333:
1327:
1323:
1322:
1319:
1318:
1310:
1309:
1303:
1300:
1299:
1291:
1290:
1284:
1278:
1277:
1274:
1273:
1265:
1264:
1258:
1255:
1254:
1246:
1245:
1239:
1233:
1232:
1229:
1228:
1220:
1219:
1213:
1210:
1209:
1201:
1200:
1194:
1188:
1187:
1182:
1177:
1173:
1172:
1162:
1161:
1158:
1157:
1146:
1145:
1143:
1142:
1137:
1132:
1127:
1122:
1117:
1112:
1107:
1102:
1097:
1092:
1087:
1082:
1077:
1072:
1067:
1062:
1057:
1052:
1047:
1042:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
997:
992:
987:
982:
977:
972:
967:
962:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
851:
849:
845:
844:
842:
841:
836:
831:
826:
821:
816:
814:early endosome
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
749:focal adhesion
746:
741:
736:
731:
725:
723:
719:
718:
716:
715:
710:
705:
700:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
645:
640:
635:
630:
624:
622:
618:
617:
607:
606:
603:
602:
599:
598:
590:
589:
571:
565:
564:
561:
560:
552:
551:
548:
547:
545:
544:
540:
536:
532:
528:
524:
520:
516:
512:
508:
504:
501:
500:
489:
486:
485:
483:
482:
478:
474:
470:
466:
462:
458:
454:
450:
446:
442:
439:
438:
426:
425:
417:
406:
400:
399:
396:RNA expression
388:
387:
384:
383:
375:
371:
370:
362:
359:
354:
348:
347:
338:
331:
325:
321:
320:
315:
309:
308:
300:
299:
287:
286:
283:
282:
274:
270:
269:
261:
258:
253:
247:
246:
237:
230:
224:
220:
219:
212:
206:
205:
197:
196:
184:
183:
140:
136:
135:
127:
119:
118:
114:
113:
110:
109:
106:
105:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
7843:
7842:
7831:
7828:
7826:
7823:
7822:
7820:
7805:
7802:
7800:
7797:
7795:
7792:
7791:
7789:
7787:
7781:
7775:
7772:
7770:
7766:
7762:
7759:
7757:
7754:
7752:
7749:
7747:
7744:
7742:
7739:
7737:
7734:
7732:
7729:
7727:
7724:
7722:
7719:
7717:
7714:
7712:
7709:
7707:
7704:
7703:
7702:
7698:
7697:
7694:
7690:
7689:
7687:
7685:
7681:
7675:
7672:
7670:
7667:
7665:
7662:
7661:
7659:
7657:
7653:
7647:
7644:
7642:
7639:
7637:
7634:
7633:
7631:
7629:
7624:
7616:
7613:
7612:
7611:
7608:
7606:
7603:
7601:
7598:
7596:
7593:
7589:
7586:
7584:
7581:
7579:
7576:
7574:
7571:
7570:
7568:
7566:
7563:
7559:
7556:
7554:
7551:
7549:
7546:
7544:
7541:
7540:
7538:
7537:
7535:
7533:
7529:
7524:
7514:
7511:
7509:
7506:
7504:
7501:
7498:
7495:
7493:
7490:
7488:
7484:
7480:
7476:
7474:
7471:
7469:
7465:
7461:
7460:
7458:
7453:
7449:
7444:
7440:
7433:
7428:
7426:
7421:
7419:
7414:
7413:
7410:
7398:
7395:
7393:
7390:
7388:
7385:
7383:
7380:
7378:
7375:
7373:
7370:
7368:
7365:
7363:
7360:
7358:
7355:
7353:
7350:
7348:
7345:
7343:
7340:
7338:
7335:
7333:
7330:
7328:
7325:
7323:
7320:
7318:
7315:
7313:
7310:
7308:
7305:
7303:
7300:
7298:
7295:
7293:
7290:
7288:
7285:
7283:
7280:
7278:
7275:
7273:
7270:
7268:
7265:
7263:
7260:
7258:
7255:
7253:
7250:
7248:
7245:
7243:
7240:
7238:
7235:
7233:
7230:
7228:
7225:
7223:
7220:
7218:
7215:
7214:
7212:
7208:
7202:
7199:
7197:
7194:
7192:
7189:
7187:
7184:
7182:
7179:
7177:
7174:
7172:
7169:
7167:
7164:
7162:
7159:
7157:
7154:
7152:
7149:
7147:
7144:
7142:
7139:
7137:
7134:
7132:
7129:
7127:
7124:
7122:
7119:
7117:
7114:
7112:
7109:
7107:
7104:
7102:
7099:
7097:
7094:
7092:
7089:
7087:
7084:
7082:
7079:
7077:
7074:
7072:
7069:
7067:
7064:
7062:
7059:
7057:
7054:
7052:
7049:
7047:
7044:
7042:
7039:
7037:
7034:
7032:
7029:
7027:
7024:
7022:
7019:
7017:
7014:
7012:
7009:
7008:
7006:
7002:
6996:
6993:
6991:
6987:
6984:
6982:
6979:
6977:
6974:
6972:
6969:
6967:
6964:
6962:
6959:
6957:
6954:
6952:
6949:
6947:
6944:
6942:
6939:
6935:
6932:
6930:
6927:
6926:
6925:
6922:
6920:
6917:
6915:
6912:
6910:
6907:
6905:
6902:
6900:
6897:
6895:
6892:
6890:
6887:
6885:
6882:
6880:
6877:
6875:
6872:
6870:
6867:
6865:
6862:
6860:
6857:
6854:
6851:
6849:
6845:
6842:
6840:
6837:
6833:
6830:
6828:
6825:
6824:
6823:
6820:
6818:
6815:
6811:
6808:
6806:
6803:
6802:
6801:
6798:
6796:
6793:
6791:
6788:
6786:
6783:
6781:
6778:
6776:
6773:
6771:
6768:
6766:
6763:
6761:
6758:
6757:
6755:
6751:
6745:
6742:
6740:
6737:
6735:
6732:
6730:
6727:
6725:
6722:
6720:
6717:
6715:
6712:
6710:
6707:
6705:
6702:
6700:
6697:
6695:
6692:
6690:
6687:
6685:
6682:
6680:
6677:
6675:
6672:
6670:
6667:
6665:
6662:
6658:
6655:
6653:
6650:
6649:
6648:
6645:
6643:
6640:
6638:
6635:
6633:
6630:
6626:
6623:
6621:
6618:
6616:
6613:
6612:
6611:
6608:
6606:
6603:
6601:
6598:
6596:
6593:
6591:
6588:
6584:
6581:
6579:
6576:
6575:
6574:
6571:
6569:
6566:
6564:
6561:
6559:
6556:
6554:
6551:
6549:
6546:
6544:
6541:
6537:
6534:
6532:
6529:
6528:
6527:
6524:
6521:
6518:
6516:
6513:
6511:
6508:
6506:
6503:
6501:
6497:
6494:
6492:
6489:
6485:
6482:
6480:
6477:
6475:
6472:
6471:
6470:
6467:
6465:
6462:
6460:
6457:
6455:
6452:
6450:
6447:
6445:
6442:
6441:
6439:
6435:
6429:
6426:
6424:
6421:
6419:
6416:
6414:
6411:
6409:
6406:
6404:
6401:
6399:
6396:
6394:
6391:
6389:
6386:
6384:
6381:
6379:
6376:
6374:
6371:
6369:
6366:
6364:
6361:
6359:
6356:
6354:
6351:
6349:
6346:
6344:
6341:
6339:
6336:
6334:
6331:
6329:
6326:
6324:
6321:
6319:
6316:
6314:
6311:
6309:
6306:
6302:
6299:
6297:
6294:
6293:
6292:
6289:
6285:
6282:
6280:
6277:
6276:
6275:
6272:
6270:
6267:
6265:
6262:
6260:
6257:
6255:
6252:
6250:
6247:
6245:
6242:
6240:
6237:
6235:
6232:
6230:
6227:
6225:
6222:
6220:
6217:
6215:
6212:
6208:
6205:
6203:
6200:
6199:
6198:
6195:
6193:
6190:
6188:
6185:
6183:
6180:
6178:
6175:
6173:
6170:
6168:
6165:
6164:
6162:
6158:
6152:
6149:
6147:
6144:
6142:
6139:
6137:
6134:
6132:
6129:
6127:
6124:
6122:
6119:
6117:
6114:
6112:
6108:
6105:
6103:
6100:
6098:
6095:
6093:
6090:
6088:
6085:
6083:
6080:
6076:
6073:
6071:
6068:
6066:
6063:
6061:
6058:
6056:
6053:
6051:
6048:
6047:
6046:
6043:
6041:
6038:
6036:
6033:
6031:
6028:
6026:
6023:
6021:
6018:
6014:
6011:
6009:
6006:
6005:
6004:
6001:
5999:
5996:
5994:
5991:
5989:
5986:
5984:
5981:
5979:
5976:
5974:
5971:
5969:
5966:
5964:
5961:
5957:
5954:
5952:
5949:
5947:
5944:
5942:
5939:
5937:
5934:
5932:
5929:
5928:
5927:
5924:
5920:
5917:
5915:
5912:
5910:
5907:
5906:
5905:
5902:
5900:
5897:
5893:
5890:
5888:
5885:
5883:
5880:
5879:
5878:
5875:
5873:
5870:
5868:
5865:
5863:
5860:
5858:
5855:
5853:
5850:
5848:
5845:
5843:
5840:
5838:
5835:
5833:
5830:
5828:
5825:
5824:
5822:
5818:
5812:
5809:
5805:
5802:
5800:
5797:
5795:
5792:
5790:
5787:
5785:
5782:
5780:
5777:
5776:
5775:
5772:
5770:
5767:
5765:
5762:
5760:
5757:
5755:
5752:
5750:
5747:
5745:
5742:
5738:
5735:
5733:
5730:
5728:
5725:
5723:
5720:
5719:
5718:
5715:
5713:
5710:
5708:
5705:
5703:
5700:
5698:
5695:
5693:
5690:
5688:
5685:
5683:
5680:
5678:
5675:
5673:
5670:
5666:
5663:
5661:
5658:
5657:
5656:
5653:
5651:
5648:
5646:
5643:
5641:
5638:
5636:
5633:
5631:
5628:
5626:
5623:
5621:
5618:
5616:
5613:
5611:
5608:
5606:
5603:
5601:
5598:
5596:
5593:
5591:
5588:
5586:
5583:
5579:
5576:
5574:
5571:
5570:
5569:
5566:
5564:
5561:
5559:
5556:
5554:
5551:
5547:
5544:
5542:
5539:
5537:
5534:
5532:
5529:
5528:
5527:
5524:
5522:
5519:
5517:
5514:
5510:
5507:
5506:
5505:
5502:
5500:
5497:
5495:
5492:
5490:
5487:
5485:
5482:
5478:
5475:
5473:
5470:
5468:
5465:
5464:
5463:
5460:
5458:
5455:
5451:
5448:
5446:
5443:
5441:
5438:
5436:
5433:
5431:
5428:
5427:
5426:
5423:
5422:
5420:
5416:
5411:
5407:
5403:
5396:
5391:
5389:
5384:
5382:
5377:
5376:
5373:
5359:
5353:
5348:
5344:
5338:
5333:
5329:
5323:
5318:
5314:
5308:
5303:
5299:
5293:
5288:
5284:
5275:
5270:
5268:
5263:
5261:
5256:
5255:
5252:
5245:
5241:
5238:
5237:
5233:
5226:
5222:
5218:
5214:
5209:
5204:
5200:
5196:
5192:
5187:
5183:
5179:
5175:
5171:
5166:
5161:
5158:(3): 447–62.
5157:
5153:
5149:
5144:
5140:
5136:
5131:
5126:
5122:
5118:
5114:
5109:
5105:
5101:
5097:
5093:
5088:
5083:
5079:
5075:
5071:
5066:
5062:
5058:
5054:
5050:
5046:
5042:
5037:
5033:
5029:
5025:
5021:
5017:
5013:
5008:
5007:
5002:
4994:
4990:
4985:
4980:
4976:
4972:
4968:
4964:
4960:
4953:
4950:
4945:
4941:
4936:
4931:
4926:
4921:
4917:
4913:
4909:
4905:
4901:
4894:
4891:
4886:
4882:
4877:
4872:
4868:
4864:
4860:
4856:
4852:
4845:
4842:
4837:
4833:
4828:
4823:
4819:
4815:
4811:
4807:
4803:
4796:
4793:
4788:
4784:
4779:
4774:
4770:
4766:
4762:
4755:
4752:
4747:
4743:
4739:
4735:
4731:
4727:
4724:(4): 766–76.
4723:
4719:
4711:
4708:
4703:
4699:
4694:
4689:
4685:
4681:
4677:
4670:
4667:
4662:
4658:
4653:
4648:
4644:
4640:
4636:
4629:
4626:
4621:
4617:
4612:
4607:
4603:
4599:
4595:
4588:
4585:
4580:
4576:
4571:
4566:
4562:
4558:
4554:
4547:
4544:
4539:
4535:
4530:
4525:
4521:
4517:
4513:
4506:
4503:
4498:
4494:
4489:
4484:
4481:(3): 303–13.
4480:
4476:
4472:
4465:
4462:
4457:
4453:
4448:
4443:
4439:
4435:
4431:
4424:
4422:
4420:
4418:
4416:
4414:
4412:
4408:
4403:
4399:
4394:
4389:
4385:
4381:
4377:
4373:
4369:
4362:
4359:
4354:
4350:
4345:
4340:
4335:
4330:
4326:
4322:
4318:
4314:
4310:
4303:
4300:
4295:
4291:
4287:
4283:
4276:
4273:
4268:
4264:
4259:
4254:
4250:
4246:
4242:
4235:
4232:
4227:
4223:
4218:
4213:
4209:
4205:
4201:
4194:
4191:
4186:
4182:
4177:
4172:
4168:
4164:
4161:(4): 454–64.
4160:
4156:
4152:
4145:
4142:
4137:
4130:
4126:
4121:
4116:
4111:
4106:
4102:
4098:
4094:
4090:
4086:
4079:
4076:
4071:
4067:
4063:
4059:
4055:
4051:
4047:
4043:
4039:
4035:
4028:
4025:
4020:
4016:
4011:
4006:
4002:
3998:
3995:(3): 689–95.
3994:
3990:
3986:
3979:
3976:
3971:
3967:
3962:
3957:
3953:
3949:
3945:
3938:
3935:
3930:
3926:
3921:
3916:
3911:
3906:
3902:
3898:
3894:
3890:
3886:
3879:
3876:
3871:
3867:
3862:
3857:
3853:
3849:
3845:
3841:
3837:
3830:
3827:
3822:
3818:
3814:
3810:
3806:
3802:
3798:
3794:
3787:
3784:
3779:
3775:
3770:
3765:
3761:
3757:
3753:
3749:
3745:
3738:
3735:
3730:
3726:
3721:
3716:
3712:
3708:
3704:
3700:
3696:
3689:
3686:
3681:
3677:
3672:
3667:
3663:
3659:
3655:
3651:
3647:
3640:
3637:
3632:
3628:
3623:
3618:
3614:
3610:
3606:
3602:
3598:
3591:
3588:
3583:
3579:
3574:
3569:
3565:
3561:
3557:
3553:
3549:
3542:
3539:
3534:
3530:
3525:
3520:
3516:
3512:
3508:
3504:
3500:
3493:
3490:
3485:
3481:
3476:
3471:
3466:
3461:
3457:
3453:
3449:
3442:
3439:
3434:
3430:
3425:
3420:
3415:
3410:
3406:
3402:
3401:FASEB Journal
3398:
3391:
3389:
3385:
3380:
3376:
3371:
3366:
3361:
3356:
3352:
3348:
3344:
3337:
3334:
3329:
3325:
3321:
3317:
3313:
3309:
3302:
3300:
3298:
3296:
3294:
3290:
3285:
3281:
3276:
3271:
3267:
3263:
3259:
3255:
3251:
3244:
3242:
3240:
3238:
3236:
3234:
3230:
3225:
3221:
3217:
3213:
3208:
3203:
3199:
3195:
3191:
3184:
3182:
3180:
3178:
3176:
3174:
3172:
3170:
3168:
3166:
3164:
3162:
3160:
3158:
3156:
3154:
3152:
3150:
3148:
3146:
3144:
3142:
3140:
3138:
3136:
3134:
3132:
3130:
3128:
3126:
3124:
3122:
3120:
3118:
3116:
3114:
3112:
3110:
3108:
3106:
3104:
3102:
3100:
3098:
3096:
3094:
3092:
3090:
3088:
3086:
3084:
3082:
3078:
3073:
3069:
3064:
3059:
3054:
3049:
3045:
3041:
3037:
3030:
3028:
3026:
3024:
3022:
3020:
3018:
3016:
3014:
3012:
3010:
3008:
3006:
3004:
3002:
3000:
2998:
2996:
2994:
2992:
2988:
2983:
2977:
2975:
2971:
2966:
2962:
2958:
2954:
2950:
2946:
2939:
2936:
2931:
2927:
2922:
2917:
2913:
2909:
2905:
2901:
2897:
2890:
2887:
2882:
2878:
2872:
2869:
2864:
2860:
2854:
2851:
2847:
2843:
2838:
2836:
2834:
2830:
2826:
2822:
2817:
2815:
2813:
2809:
2803:
2799:
2796:
2794:
2791:
2790:
2786:
2776:
2769:
2766:
2759:
2754:
2746:
2684:
2372:
2357:
2356:
2349:
2343:
2340:
2337:
2334:
2331:
2328:
2325:
2322:
2319:
2316:
2313:
2310:
2307:
2304:
2301:
2298:
2295:
2292:
2289:
2286:
2283:
2280:
2277:
2274:
2271:
2268:
2265:
2262:
2259:
2256:
2253:
2250:
2247:
2244:
2241:
2238:
2235:
2232:
2229:
2226:
2223:
2220:
2217:
2214:
2211:
2208:
2205:
2202:
2199:
2196:
2193:
2190:
2187:
2184:
2181:
2178:
2175:
2172:
2169:
2166:
2163:
2160:
2157:
2154:
2151:
2148:
2145:
2142:
2139:
2136:
2133:
2130:
2127:
2124:
2121:
2118:
2115:
2112:
2109:
2106:
2103:
2099:
2095:
2091:
2088:
2085:
2082:
2079:
2076:
2073:
2070:
2067:
2064:
2061:
2058:
2055:
2052:
2049:
2046:
2043:
2040:
2037:
2036:Complement C3
2034:
2031:
2028:
2025:
2022:
2019:
2016:
2013:
2010:
2007:
2004:
2001:
1998:
1994:
1991:
1988:
1985:
1982:
1979:
1976:
1973:
1970:
1966:
1963:
1960:
1957:
1956:
1954:
1952:
1944:
1942:
1940:
1936:
1935:degranulation
1932:
1928:
1924:
1920:
1916:
1912:
1908:
1904:
1900:
1896:
1888:
1886:
1884:
1880:
1876:
1872:
1868:
1860:
1858:
1856:
1852:
1848:
1844:
1839:
1836:
1832:
1827:
1825:
1821:
1817:
1813:
1801:
1799:
1796:
1792:
1788:
1784:
1780:
1776:
1772:
1768:
1764:
1760:
1756:
1752:
1749:, as well as
1748:
1744:
1740:
1736:
1732:
1729:
1725:
1721:
1717:
1714:
1710:
1707:
1703:
1699:
1695:
1691:
1688:
1684:
1676:
1674:
1672:
1668:
1664:
1661:
1657:
1653:
1649:
1645:
1642:
1638:
1635:
1631:
1627:
1623:
1619:
1615:
1611:
1610:transmembrane
1607:
1603:
1599:
1595:
1594:Golgi complex
1592:in the trans-
1591:
1587:
1583:
1575:
1573:
1571:
1567:
1563:
1559:
1555:
1554:cell motility
1551:
1548:
1544:
1540:
1537:
1533:
1529:
1525:
1522:found in the
1521:
1517:
1513:
1509:
1505:
1501:
1497:
1493:
1489:
1485:
1473:
1468:
1464:
1460:
1457:
1453:
1446:
1444:
1441:
1437:
1433:
1429:
1426:
1422:
1418:
1411:
1409:
1403:
1399:
1396:
1390:
1388:
1382:
1378:
1375:
1371:
1364:
1362:
1356:
1352:
1349:
1343:
1341:
1335:
1331:
1328:
1326:RefSeq (mRNA)
1324:
1317:
1316:
1311:
1307:
1304:
1298:
1297:
1292:
1288:
1285:
1283:
1279:
1272:
1271:
1266:
1262:
1259:
1253:
1252:
1247:
1243:
1240:
1238:
1234:
1227:
1226:
1221:
1217:
1214:
1208:
1207:
1202:
1198:
1195:
1193:
1189:
1186:
1183:
1181:
1178:
1174:
1171:
1167:
1163:
1156:
1152:
1147:
1141:
1138:
1136:
1133:
1131:
1128:
1126:
1123:
1121:
1118:
1116:
1113:
1111:
1108:
1106:
1103:
1101:
1098:
1096:
1093:
1091:
1088:
1086:
1083:
1081:
1078:
1076:
1073:
1071:
1068:
1066:
1063:
1061:
1058:
1056:
1053:
1051:
1048:
1046:
1043:
1041:
1038:
1036:
1033:
1031:
1028:
1026:
1023:
1021:
1018:
1016:
1013:
1011:
1008:
1006:
1003:
1001:
998:
996:
993:
991:
988:
986:
983:
981:
978:
976:
973:
971:
968:
966:
963:
961:
958:
956:
953:
951:
948:
946:
943:
941:
938:
936:
933:
931:
928:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
896:
893:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
852:
850:
847:
846:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
726:
724:
721:
720:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
629:
626:
625:
623:
620:
619:
616:
615:Gene ontology
612:
608:
596:
591:
587:
580:
575:
572:
570:
566:
558:
553:
542:
538:
534:
530:
526:
522:
518:
514:
510:
506:
505:
502:
498:
493:
490:
480:
476:
472:
468:
464:
460:
456:
452:
448:
444:
443:
440:
436:
431:
428:
427:
424:
422:
418:
416:
415:
411:
410:
407:
405:
401:
397:
393:
389:
381:
376:
372:
368:
363:
357:10|10 D3
353:
349:
342:
335:
329:
322:
314:
310:
306:
301:
297:
292:
288:
280:
275:
271:
267:
262:
252:
248:
241:
234:
228:
221:
217:
211:
207:
203:
198:
194:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
137:
132:
125:
120:
115:
104:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
7784:ATP-binding
7705:
7477:delivery of
7462:delivery of
6923:
6843:
6821:
6799:
6646:
6609:
6572:
6525:
6495:
6468:
6290:
6196:
6106:
6044:
5773:
5525:
5357:
5342:
5327:
5312:
5297:
5240:CD91+Antigen
5198:
5194:
5155:
5151:
5120:
5116:
5077:
5073:
5047:(4): 160–5.
5044:
5040:
5024:10.2741/A808
5015:
5011:
4966:
4962:
4952:
4907:
4903:
4893:
4861:(2): 542–9.
4858:
4854:
4844:
4809:
4805:
4795:
4768:
4764:
4754:
4721:
4717:
4710:
4683:
4679:
4669:
4642:
4638:
4628:
4601:
4597:
4587:
4560:
4556:
4546:
4519:
4515:
4505:
4478:
4474:
4464:
4437:
4433:
4375:
4371:
4361:
4316:
4312:
4302:
4285:
4281:
4275:
4248:
4244:
4234:
4210:(5): 670–7.
4207:
4203:
4193:
4158:
4154:
4144:
4092:
4088:
4078:
4037:
4033:
4027:
3992:
3988:
3978:
3951:
3947:
3937:
3892:
3888:
3878:
3843:
3839:
3829:
3799:(1): 13–21.
3796:
3792:
3786:
3751:
3747:
3737:
3702:
3698:
3688:
3653:
3649:
3639:
3607:(1): 16–30.
3604:
3600:
3590:
3558:(1): 66–78.
3555:
3551:
3541:
3506:
3502:
3492:
3455:
3451:
3441:
3404:
3400:
3350:
3346:
3336:
3311:
3307:
3257:
3253:
3197:
3193:
3043:
3039:
2948:
2944:
2938:
2903:
2899:
2889:
2880:
2871:
2862:
2853:
2768:
2354:
2353:
1948:
1945:Interactions
1892:
1877:in vascular
1871:lipoproteins
1864:
1847:amyloid beta
1840:
1828:
1810:
1743:inflammation
1731:permeability
1722:regulation,
1680:
1581:
1579:
1535:
1511:
1507:
1503:
1499:
1495:
1491:
1487:
1483:
1482:
1405:
1384:
1358:
1337:
1313:
1294:
1268:
1249:
1223:
1204:
1184:
1179:
1040:transcytosis
990:phagocytosis
900:human ageing
469:tibial nerve
419:
412:
378:127,457,017
365:127,374,030
139:External IDs
74:
18:
7468:Chylomicron
7452:Lipoprotein
7443:lipoprotein
5280:PDB gallery
4288:(3): 21–3.
4155:Circulation
4095:(5): e448.
2951:(1): 65–9.
2228:Polymyxin B
2180:Neuroserpin
2126:Lactoferrin
2072:Fibronectin
2066:Factor VIIa
2018:Chylomicron
1929:to recruit
1883:macrophages
1849:across the
1824:Alzheimer's
1816:cholesterol
1755:co-receptor
1735:cell growth
1716:degradation
1706:lipoprotein
1694:hepatocytes
1667:endocytosis
1663:cytoplasmic
1641:lipoprotein
1614:cytoplasmic
1547:lipoprotein
1532:endocytosis
875:endocytosis
668:RNA binding
477:sural nerve
457:right ovary
277:57,213,361
264:57,128,483
117:Identifiers
7819:Categories
5408:(see also
3254:Oncotarget
3046:: 152163.
2848:, May 2017
2827:, May 2017
2804:References
2078:Gentamicin
2060:Factor IXa
1931:mast cells
1795:ectodomain
1709:metabolism
1644:metabolism
1624:proteins,
1606:EGF (gene)
1598:covalently
1560:, such as
1550:metabolism
1543:signalling
1518:forming a
461:left ovary
423:(ortholog)
160:HomoloGene
3353:(1): 14.
3314:: 15–23.
2030:Collectin
2000:inhibitor
1987:Aprotinin
1765:, to the
1747:apoptosis
1656:endosomes
1637:complexes
1630:proteases
1576:Structure
1408:NP_032538
1387:NP_002323
1361:NM_008512
1340:NM_002332
1170:Orthologs
804:cytoplasm
784:nucleolus
168:GeneCards
5402:Proteins
5225:20991690
5217:16102056
5182:83711249
5174:16088940
5139:15705932
5104:23565545
5096:12713657
5061:12069755
5032:11861214
4993:11359936
4885:10632583
4746:12198474
4738:14991768
4702:11854294
4661:12789267
4639:Oncogene
4497:11290339
4475:Immunity
4456:10827173
4402:12821648
4226:17303763
4185:21730304
4129:17505534
4089:PLOS ONE
4062:12690199
3970:19667105
3929:23959870
3870:25015123
3821:30189180
3813:22572854
3778:11120756
3729:11067868
3680:26619118
3631:19275634
3582:17920016
3533:18199803
3484:19371428
3433:21518850
3379:27503326
3328:24796846
3284:26164207
3224:20991690
3216:16102056
3072:23936774
2945:Genomics
2844:–
2823:–
2787:See also
2282:Thrombin
2150:MAPK8IP2
2144:MAPK8IP1
2120:ITGB1BP1
2054:Elastase
1951:interact
1814:require
1785:. While
1767:lysosome
1751:diseases
1724:integrin
1713:protease
1692:(SMCs),
1687:vascular
1677:Function
1558:diseases
1520:receptor
1514:), is a
1456:Wikidata
1149:Sources:
779:dendrite
744:membrane
739:endosome
7628:enzymes
7210:301–350
7004:251–300
6956:CD240CE
6753:201–250
6437:151–200
6160:101–150
5074:Traffic
4944:1502153
4912:Bibcode
4876:6772406
4836:7775583
4827:2120467
4787:9045712
4620:1281473
4579:7989348
4538:7510694
4393:2172996
4353:2762297
4321:Bibcode
4267:9837937
4176:3144781
4120:1864997
4097:Bibcode
4070:2070128
4042:Bibcode
4034:Science
4019:9449704
3920:3767519
3897:Bibcode
3861:4280344
3671:4701557
3622:2872930
3573:2045076
3524:2391054
3475:2672942
3424:3470721
3370:4977753
3275:4695142
3063:3723059
2965:2548950
2930:3266596
2846:Ensembl
2825:Ensembl
2364:[[File:
2270:SYNJ2BP
2186:Nexin-1
2156:Midkine
1895:plasmin
1875:PDGFR-β
1812:Neurons
1793:of its
1698:neurons
1683:tissues
1660:residue
1650:in low
1648:ligands
1516:protein
1282:UniProt
1237:Ensembl
1176:Species
1155:QuickGO
809:cytosol
799:nucleus
398:pattern
256:12q13.3
124:Aliases
7774:LRPAP1
7693:SCARB1
7499:sd LDL
7496:lb LDL
7439:Lipids
7217:CD300A
7176:CDw293
6961:CD240D
6822:CD213a
6800:CDw210
6765:CD202b
6739:CDw199
6734:CDw198
6388:CD140b
5820:51–100
5246:(MeSH)
5223:
5215:
5180:
5172:
5137:
5102:
5094:
5059:
5030:
4991:
4981:
4942:
4932:
4883:
4873:
4834:
4824:
4785:
4744:
4736:
4700:
4659:
4618:
4577:
4536:
4495:
4454:
4400:
4390:
4351:
4344:297720
4341:
4294:277965
4292:
4265:
4224:
4183:
4173:
4127:
4117:
4068:
4060:
4017:
4010:508614
4007:
3968:
3927:
3917:
3868:
3858:
3819:
3811:
3776:
3769:387254
3766:
3727:
3720:301422
3717:
3678:
3668:
3629:
3619:
3580:
3570:
3552:Neuron
3531:
3521:
3482:
3472:
3458:: 17.
3431:
3421:
3377:
3367:
3326:
3282:
3272:
3222:
3214:
3070:
3060:
2963:
2928:
2921:455121
2918:
2192:NOS1AP
1953:with:
1939:glioma
1911:pepsin
1901:, and
1889:Cancer
1843:copper
1745:, and
1696:, and
1618:ligand
1570:cancer
1568:, and
1556:, and
1506:) or
1442:search
1440:PubMed
1315:Q91ZX7
1296:Q07954
1192:Entrez
569:BioGPS
148:107770
7804:ABCG8
7799:ABCG5
7794:ABCA1
7767:LDL:
7761:LRP12
7756:LRP11
7751:LRP10
7736:LRP5L
7711:LRP1B
7699:IDL:
7691:HDL:
7569:APOC
7539:APOA
7503:Lp(a)
7397:CD350
7392:CD349
7387:CD344
7382:CD340
7377:CD339
7372:CD338
7367:CD337
7362:CD336
7357:CD335
7352:CD334
7347:CD333
7342:CD332
7337:CD331
7332:CD329
7327:CD328
7322:CD327
7317:CD326
7312:CD325
7307:CD324
7302:CD322
7297:CD321
7292:CD320
7287:CD318
7282:CD317
7277:CD316
7272:CD315
7267:CD314
7262:CD312
7257:CD309
7252:CD307
7247:CD306
7242:CD305
7237:CD304
7232:CD303
7227:CD302
7222:CD301
7201:CD299
7196:CD298
7191:CD297
7186:CD295
7181:CD294
7171:CD292
7166:CD290
7161:CD289
7156:CD288
7151:CD286
7146:CD284
7141:CD283
7136:CD282
7131:CD281
7126:CD280
7121:CD279
7116:CD278
7111:CD276
7106:CD275
7101:CD274
7096:CD273
7091:CD272
7086:CD271
7081:CD269
7076:CD268
7071:CD267
7066:CD266
7061:CD265
7056:CD264
7051:CD263
7046:CD262
7041:CD261
7036:CD258
7031:CD257
7026:CD256
7021:CD254
7016:CD253
7011:CD252
6995:CD249
6990:CD248
6986:CD247
6981:CD246
6976:CD244
6971:CD243
6966:CD241
6951:CD239
6946:CD238
6941:CD236
6924:CD235
6919:CD234
6914:CD233
6909:CD230
6904:CD229
6899:CD228
6894:CD227
6889:CD226
6884:CD225
6879:CD224
6874:CD223
6869:CD222
6864:CD221
6859:CD220
6844:CD218
6839:CD217
6817:CD212
6795:CD209
6790:CD208
6785:CD207
6780:CD206
6775:CD205
6770:CD204
6760:CD201
6744:CD200
6729:CD197
6724:CD196
6719:CD195
6714:CD194
6709:CD193
6704:CD192
6699:CD191
6694:CD186
6689:CD185
6684:CD184
6679:CD183
6674:CD182
6669:CD181
6664:CD180
6647:CD179
6642:CD178
6637:CD177
6632:CD174
6610:CD172
6605:CD171
6600:CD170
6595:CD169
6590:CD168
6573:CD167
6568:CD166
6563:CD164
6558:CD163
6553:CD162
6548:CD161
6543:CD160
6526:CD159
6496:CD158
6491:CD157
6469:CD156
6464:CD155
6459:CD154
6454:CD153
6449:CD152
6444:CD151
6428:CD150
6423:CD148
6418:CD147
6413:CD146
6408:CD144
6403:CD143
6398:CD142
6393:CD141
6383:CD138
6378:CD137
6373:CD136
6368:CD135
6363:CD134
6358:CD133
6353:CD132
6348:CD131
6343:CD130
6338:CD129
6333:CD127
6328:CD126
6323:CD125
6318:CD124
6313:CD123
6308:CD122
6291:CD121
6274:CD120
6269:CD119
6264:CD118
6259:CD117
6254:CD116
6249:CD115
6244:CD114
6239:CD113
6234:CD112
6229:CD111
6224:CD110
6219:CD109
6214:CD108
6197:CD107
6192:CD106
6187:CD105
6182:CD104
6177:CD103
6172:CD102
6167:CD101
6151:CD100
5221:S2CID
5178:S2CID
5100:S2CID
4984:34598
4935:49722
4742:S2CID
4066:S2CID
3817:S2CID
3220:S2CID
2676:]
2336:PLAUR
2312:TIMP3
2306:TIMP2
2300:TIMP1
2288:THBS1
2260:, and
2252:Ricin
2204:PAI-1
2198:PAI 2
2162:MMP13
2102:hsp90
2098:hsp70
2084:GIPC1
1975:APBB1
1927:PAI-1
1702:lipid
1590:furin
1528:cells
1504:APOER
1225:16971
1185:Mouse
1180:Human
1151:Amigo
523:ankle
421:Mouse
414:Human
361:Start
296:Mouse
260:Start
193:Human
156:96828
7769:LDLR
7746:LRP8
7741:LRP6
7731:LRP5
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7706:LRP1
7674:PLTP
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7664:CETP
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7636:LCAT
7615:SAA1
7605:APOH
7600:APOE
7595:APOD
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7481:and
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2745:edit
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