180:
380:
40:
412:
Ornstein PL, Bleisch TJ, Arnold MB, Kennedy JH, Wright RA, Johnson BG, Tizzano JP, Helton DR, Kallman MJ, Schoepp DD, Hérin M (January 1998). "2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2.
918:
Fischer BD, Miller LL, Henry FE, Picker MJ, Dykstra LA (June 2008). "Increased efficacy of micro-opioid agonist-induced antinociception by metabotropic glutamate receptor antagonists in C57BL/6 mice: comparison with (-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959)".
615:
Matrisciano F, Panaccione I, Zusso M, Giusti P, Tatarelli R, Iacovelli L, Mathé AA, Gruber SH, Nicoletti F, Girardi P (August 2007). "Group-II metabotropic glutamate receptor ligands as adjunctive drugs in the treatment of depression: a new strategy to shorten the latency of antidepressant
492:
Fitzjohn SM, Bortolotto ZA, Palmer MJ, Doherty AJ, Ornstein PL, Schoepp DD, Kingston AE, Lodge D, Collingridge GL (December 1998). "The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity".
536:
Johnson BG, Wright RA, Arnold MB, Wheeler WJ, Ornstein PL, Schoepp DD (October 1999). "-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells".
1134:
Sakagami K, Yasuhara A, Chaki S, Yoshikawa R, Kawakita Y, Saito A, Taguchi T, Nakazato A (April 2008). "Synthesis, in vitro pharmacology, and pharmacokinetic profiles of 2--1-fluorocyclopropanecarboxylic acid and its 6-heptyl ester, a potent mGluR2 antagonist".
792:
Benneyworth MA, Xiang Z, Smith RL, Garcia EE, Conn PJ, Sanders-Bush E (August 2007). "A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis".
1187:
448:
Kingston AE, Ornstein PL, Wright RA, Johnson BG, Mayne NG, Burnett JP, Belagaje R, Wu S, Schoepp DD (1998). "LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors".
250:
962:
Fischer BD, Zimmerman EI, Picker MJ, Dykstra LA (February 2008). "Morphine in combination with metabotropic glutamate receptor antagonists on schedule-controlled responding and thermal nociception".
1048:
Chi H, Jang JK, Kim JH, Vezina P (October 2006). "Blockade of group II metabotropic glutamate receptors in the nucleus accumbens produces hyperlocomotion in rats previously exposed to amphetamine".
1091:
Yoon HS, Jang JK, Kim JH (September 2008). "Blockade of group II metabotropic glutamate receptors produces hyper-locomotion in cocaine pre-exposed rats by interactions with dopamine receptors".
1005:
O'Neill MF, Heron-Maxwell C, Conway MW, Monn JA, Ornstein P (October 2003). "Group II metabotropic glutamate receptor antagonists LY341495 and LY366457 increase locomotor activity in mice".
1180:
659:
Koike H, Chaki S (September 2014). "Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats".
2199:
308:
1173:
838:"The role of 5-HT2A, 5-HT 2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice"
2219:
2195:
292:
InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
264:
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902:
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2224:
1882:
1483:
885:
Moreno JL, González-Maeso J (2018). "Crosstalk
Between 5-HT2A and mGlu2 Receptors: Implications in Schizophrenia and Its Treatment".
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effects in animal models, increasing the behavioural effects of hallucinogenic drugs in animal tests, and increasing the
2191:
139:
159:
580:
Pilc A, Chaki S, Nowak G, Witkin JM (March 2008). "Mood disorders: regulation by metabotropic glutamate receptors".
1364:
753:"Behavioral evidence for interactions between a hallucinogenic drug and group II metabotropic glutamate receptors"
332:, which acts as a potent and selective orthosteric antagonist for the group II metabotropic glutamate receptors (
1738:
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704:"Fast-acting antidepressants rapidly stimulate ERK signaling and BDNF release in primary neuronal cultures"
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Effects of aromatic substitution, pharmacological characterization, and bioavailability".
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Carbonaro TM, Eshleman AJ, Forster MJ, Cheng K, Rice KC, Gatch MB (January 2015).
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from this with the heptyl ester increases bioavailability still further.
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It is used in scientific research in several different areas, showing
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2018:
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Lepack AE, Bang E, Lee B, Dwyer JM, Duman RS (December 2016).
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is a research drug developed by the pharmaceutical company
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The
Journal of Pharmacology and Experimental Therapeutics
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889:. The Receptors. Vol. 32. pp. 147–189.
272:C1(1(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O
364:The 1-fluorocyclopropane analog has a superior
107:
887:5-HT2A Receptors in the Central Nervous System
1181:
8:
30:
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2200:Glutamate metabolism/transport modulators
2107:Tooltip Metabotropic glutamate receptor 8
2008:Tooltip Metabotropic glutamate receptor 7
1936:Tooltip Metabotropic glutamate receptor 6
1832:Tooltip Metabotropic glutamate receptor 4
1683:Tooltip Metabotropic glutamate receptor 3
1525:Tooltip Metabotropic glutamate receptor 2
1339:Tooltip Metabotropic glutamate receptor 5
1225:Tooltip Metabotropic glutamate receptor 1
861:
768:
727:
147:
60:)-2-Amino-2--3-(xanth-9-yl)propanoic acid
2220:Drugs developed by Eli Lilly and Company
2196:Ionotropic glutamate receptor modulators
404:
289:
269:
174:
79:
751:Gewirtz JC, Marek GJ (November 2000).
29:
7:
1137:Bioorganic & Medicinal Chemistry
1739:Pomaglumetad methionil (LY-2140023)
1591:Pomaglumetad methionil (LY-2140023)
25:
1105:10.1016/j.neuropharm.2008.07.012
1062:10.1016/j.neuropharm.2006.06.008
720:10.1016/j.neuropharm.2016.09.011
383:1-fluoro-LY-341,495 heptyl ester
213:
207:
38:
2135:Positive allosteric modulators:
2086:Negative allosteric modulators:
1875:Positive allosteric modulators:
1793:Negative allosteric modulators:
1657:Negative allosteric modulators:
1600:Positive allosteric modulators:
1456:Negative allosteric modulators:
1399:Positive allosteric modulators:
1197:Metabotropic glutamate receptor
297:Key:VLZBRVJVCCNPRJ-KPHUOKFYSA-N
415:Journal of Medicinal Chemistry
216:
201:
1:
2192:Receptor/signaling modulators
1019:10.1016/S0028-3908(03)00232-6
770:10.1016/S0893-133X(00)00136-6
551:10.1016/s0028-3908(99)00053-2
507:10.1016/s0028-3908(98)00145-2
463:10.1016/s0028-3908(97)00191-3
895:10.1007/978-3-319-70474-6_7
2251:
2230:MGlu3 receptor antagonists
2225:MGlu2 receptor antagonists
661:Behavioural Brain Research
191:Chemical and physical data
2185:
1724:LY-404,039 (pomaglumetad)
1571:LY-404,039 (pomaglumetad)
1149:10.1016/j.bmc.2008.02.066
933:10.1007/s00213-008-1130-y
854:10.1007/s00213-014-3658-3
673:10.1016/j.bbr.2014.05.065
594:10.1016/j.bcp.2007.09.021
368:profile and similar mGluR
305:
280:
260:
70:
37:
1603:JNJ-40411813 (ADX-71149)
582:Biochemical Pharmacology
357:, as well as modulating
976:10.1124/jpet.107.131417
757:Neuropsychopharmacology
372:affinity, and making a
807:10.1124/mol.107.035170
795:Molecular Pharmacology
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630:10.1038/sj.mp.4002005
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618:Molecular Psychiatry
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1093:Neuropharmacology
1050:Neuropharmacology
1007:Neuropharmacology
904:978-3-319-70472-2
708:Neuropharmacology
539:Neuropharmacology
495:Neuropharmacology
451:Neuropharmacology
427:10.1021/jm970498o
359:dopamine receptor
323:
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251:Interactive image
160:CompTox Dashboard
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27:Chemical compound
16:(Redirected from
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588:(5): 997–1006.
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1714:Ibotenic acid
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1561:Ibotenic acid
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1547:
1544:
1542:
1539:
1537:
1534:
1531:
1530:
1528:
1523:
1514:
1511:
1509:
1505:
1495:
1492:
1490:
1487:
1485:
1482:
1480:
1477:
1475:
1472:
1470:
1467:
1465:
1462:
1460:
1457:
1453:
1450:
1448:
1445:
1443:
1440:
1438:
1435:
1433:
1430:
1428:
1425:
1423:
1420:
1418:
1415:
1413:
1410:
1407:
1406:
1403:
1400:
1396:
1393:
1391:
1388:
1386:
1385:Ibotenic acid
1383:
1381:
1378:
1376:
1373:
1371:
1368:
1366:
1363:
1361:
1358:
1356:
1353:
1351:
1348:
1345:
1344:
1342:
1337:
1328:
1322:
1319:
1317:
1314:
1312:
1309:
1307:
1304:
1302:
1301:Cyclothiazide
1299:
1297:
1294:
1292:
1289:
1286:
1285:
1282:
1279:
1277:
1274:
1272:
1269:
1267:
1264:
1262:
1259:
1257:
1254:
1252:
1251:Ibotenic acid
1249:
1247:
1244:
1242:
1239:
1237:
1234:
1231:
1230:
1228:
1223:
1214:
1211:
1209:
1205:
1201:
1198:
1191:
1186:
1184:
1179:
1177:
1172:
1171:
1168:
1158:
1154:
1150:
1146:
1142:
1138:
1130:
1127:
1122:
1118:
1114:
1110:
1106:
1102:
1098:
1094:
1087:
1084:
1079:
1075:
1071:
1067:
1063:
1059:
1056:(5): 986–92.
1055:
1051:
1044:
1041:
1036:
1032:
1028:
1024:
1020:
1016:
1013:(5): 565–74.
1012:
1008:
1001:
998:
993:
989:
985:
981:
977:
973:
969:
965:
958:
955:
950:
946:
942:
938:
934:
930:
926:
922:
914:
911:
906:
900:
896:
892:
888:
881:
878:
873:
869:
864:
859:
855:
851:
848:(1): 275–84.
847:
843:
839:
832:
829:
824:
820:
816:
812:
808:
804:
801:(2): 477–84.
800:
796:
788:
785:
780:
776:
771:
766:
763:(5): 569–76.
762:
758:
754:
747:
744:
739:
735:
730:
725:
721:
717:
713:
709:
705:
698:
695:
690:
686:
682:
678:
674:
670:
666:
662:
655:
652:
647:
643:
639:
635:
631:
627:
623:
619:
611:
608:
603:
599:
595:
591:
587:
583:
576:
573:
568:
564:
560:
556:
552:
548:
544:
540:
532:
529:
524:
520:
516:
512:
508:
504:
500:
496:
488:
485:
480:
476:
472:
468:
464:
460:
456:
452:
444:
441:
436:
432:
428:
424:
421:(3): 358–78.
420:
416:
408:
405:
399:
395:
392:
391:
387:
381:
377:
375:
367:
362:
360:
356:
353:
349:
345:
340:
338:
331:
327:
317:
310:
304:
295:
290:
286:
279:
270:
266:
259:
252:
248:
247:
245:
242:
237:
230:
228:
224:
200:
198:
194:
189:
181:
177:
173:
172:
170:
161:
157:
150:
146:
145:
143:
141:
137:
130:
126:
125:
123:
121:
117:
110:
106:
105:
103:
101:
97:
85:
80:
76:
69:
64:
59:
54:
50:
47:Clinical data
45:
41:
36:
19:
2188:
2187:
2145:Antagonists:
2144:
2134:
2114:
2085:
2044:Antagonists:
2043:
2015:
1962:Antagonists:
1961:
1943:
1890:Antagonists:
1889:
1874:
1839:
1792:
1751:Antagonists:
1750:
1744:Talaglumetad
1690:
1656:
1610:Antagonists:
1609:
1599:
1596:Talaglumetad
1532:
1469:Dipraglurant
1464:Basimglurant
1455:
1409:Antagonists:
1408:
1398:
1346:
1288:Antagonists:
1287:
1232:
1140:
1136:
1129:
1099:(4): 555–9.
1096:
1092:
1086:
1053:
1049:
1043:
1010:
1006:
1000:
970:(2): 732–9.
967:
963:
957:
927:(2): 271–8.
924:
920:
913:
886:
880:
845:
841:
831:
798:
794:
787:
760:
756:
746:
711:
707:
697:
664:
660:
654:
624:(8): 704–6.
621:
617:
610:
585:
581:
575:
542:
538:
531:
498:
494:
487:
454:
450:
443:
418:
414:
407:
363:
341:
325:
324:
313:
307:
83:
57:
1871:VU-0155,041
1796:Decoglurant
1660:Decoglurant
1494:Raseglurant
1442:Remeglurant
1427:Mavoglurant
1291:BAY 36-7620
714:: 242–252.
457:(1): 1–12.
350:effects of
234: g·mol
109:201943-63-7
66:Identifiers
52:Other names
2214:Categories
2138:AZ12216052
1878:Foliglurax
1866:VU-001,171
1779:LY-341,495
1774:LY-307,452
1729:LY-487,379
1719:LY-379,268
1638:LY-341,495
1633:LY-307,452
1581:LY-566,332
1576:LY-487,379
1566:LY-379,268
1422:LY-344,545
1402:LSN2463359
1311:LY-456,236
1306:LY-367,385
1200:modulators
400:References
361:function.
239:3D model (
227:Molar mass
149:AQ73SP6QSF
120:ChemSpider
100:CAS Number
75:IUPAC name
18:LY-341,495
2235:Xanthenes
2189:See also:
2123:Glutamate
2115:Agonists:
2037:LSP2-9166
2024:Glutamate
2016:Agonists:
1947:Glutamate
1944:Agonists:
1856:LSP2-9166
1843:Glutamate
1840:Agonists:
1815:Group III
1801:RO4491533
1709:Glutamate
1704:Eglumegad
1691:Agonists:
1665:RO4491533
1556:Glutamate
1551:Eglumegad
1533:Agonists:
1380:Glutamate
1355:ADX-47273
1347:Agonists:
1271:Ro67-7476
1266:Ro67-4853
1261:Ro01-6128
1246:Glutamate
1233:Agonists:
667:: 111–5.
348:analgesic
330:Eli Lilly
326:LY-341495
32:LY-341495
2173:UBP-1112
2089:ADX71743
2077:UBP-1112
1990:UBP-1112
1918:UBP-1112
1789:MGS-0039
1734:MGS-0028
1648:MGS-0039
1586:MGS-0028
1508:Group II
1452:SIB-1893
1447:SIB-1757
1437:NPS-2390
1321:NPS-2390
1281:Theanine
1157:18348906
1121:12164609
1113:18675831
1078:22562384
1070:16901517
1035:22992987
1027:12941370
992:12497552
984:17982001
949:24658889
941:18392754
872:24985890
815:17526600
779:11027922
738:27634096
689:19982406
681:24909673
638:17653204
602:18164691
567:36767061
559:10530814
523:26102806
479:27186381
388:See also
355:agonists
352:μ-opioid
316:(verify)
90:-alanine
1479:GRN-529
1474:Fenobam
1459:AZD9272
1395:VU-1545
1296:CPCCOEt
1208:Group I
863:4282596
823:3097502
729:5075989
646:7906551
515:9886667
471:9680254
435:9464367
374:prodrug
232:353.374
197:Formula
129:7995676
82:2--3-(9
2082:XAP044
2019:AMN082
1699:DCG-IV
1694:CBiPES
1653:PCCG-4
1546:DCG-IV
1541:CBiPES
1155:
1119:
1111:
1076:
1068:
1033:
1025:
990:
982:
947:
939:
901:
870:
860:
821:
813:
777:
736:
726:
687:
679:
644:
636:
600:
565:
557:
521:
513:
477:
469:
433:
265:SMILES
2100:mGluR
2057:MMPIP
2001:mGluR
1929:mGluR
1861:PHCCC
1825:mGluR
1769:HYDIA
1759:CECXG
1754:APICA
1676:mGluR
1628:HYDIA
1618:CECXG
1613:APICA
1518:mGluR
1417:DMeOB
1360:CDPPB
1332:mGluR
1276:VU-71
1218:mGluR
1117:S2CID
1074:S2CID
1031:S2CID
988:S2CID
945:S2CID
819:S2CID
685:S2CID
642:S2CID
563:S2CID
519:S2CID
475:S2CID
394:CECXG
334:mGluR
285:InChI
241:JSmol
2168:MTPG
2163:MSOP
2158:MPPG
2153:MAP4
2148:CPPG
2131:-AP4
2118:DCPG
2072:MTPG
2067:MSOP
2062:MPPG
2052:MAP4
2047:CPPG
2032:-AP4
1985:MTPG
1980:MSOP
1975:MPPG
1970:MAP4
1965:CPPG
1955:-AP4
1913:MTPG
1908:MSOP
1903:MPPG
1898:MAP4
1893:CPPG
1883:MPEP
1851:-AP4
1784:MCPG
1764:EGLU
1643:MCPG
1623:EGLU
1536:BINA
1489:MTEP
1484:MPEP
1432:MCPG
1412:CTEP
1375:DHPG
1365:CHPG
1350:ACPD
1316:MCPG
1241:DHPG
1236:ACPD
1153:PMID
1109:PMID
1066:PMID
1023:PMID
980:PMID
937:PMID
899:ISBN
868:PMID
811:PMID
775:PMID
734:PMID
677:PMID
634:PMID
598:PMID
555:PMID
511:PMID
467:PMID
431:PMID
140:UNII
1370:DFB
1145:doi
1101:doi
1058:doi
1015:doi
972:doi
968:324
929:doi
925:198
891:doi
858:PMC
850:doi
846:232
803:doi
765:doi
724:PMC
716:doi
712:111
669:doi
665:271
626:doi
590:doi
547:doi
503:doi
459:doi
423:doi
370:2/3
339:).
336:2/3
165:EPA
2216::
2198:•
2194:•
2133:;
2084:;
1873:;
1791:;
1655:;
1598:;
1454:;
1397:;
1151:.
1141:16
1139:.
1115:.
1107:.
1097:55
1095:.
1072:.
1064:.
1054:51
1052:.
1029:.
1021:.
1011:45
1009:.
986:.
978:.
966:.
943:.
935:.
923:.
897:.
866:.
856:.
844:.
840:.
817:.
809:.
799:72
797:.
773:.
761:23
759:.
755:.
732:.
722:.
710:.
706:.
683:.
675:.
663:.
640:.
632:.
622:12
620:.
596:.
586:75
584:.
561:.
553:.
543:38
541:.
517:.
509:.
499:37
497:.
473:.
465:.
455:37
453:.
429:.
419:41
417:.
211:19
205:20
56:(2
2129:L
2102:8
2030:L
2003:7
1953:L
1931:6
1849:L
1827:4
1678:3
1520:2
1334:5
1220:1
1189:e
1182:t
1175:v
1159:.
1147::
1123:.
1103::
1080:.
1060::
1037:.
1017::
994:.
974::
951:.
931::
907:.
893::
874:.
852::
825:.
805::
781:.
767::
740:.
718::
691:.
671::
648:.
628::
604:.
592::
569:.
549::
525:.
505::
481:.
461::
437:.
425::
243:)
220:5
217:O
214:N
208:H
202:C
167:)
163:(
88:D
84:H
58:S
20:)
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