187:
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29:
837:
Carter K, Dickerson J, Schoepp DD, Reilly M, Herring N, Williams J, et al. (December 2004). "The mGlu2/3 receptor agonist LY379268 injected into cortex or thalamus decreases neuronal injury in retrosplenial cortex produced by NMDA receptor antagonist MK-801: possible implications for psychosis".
973:
Fell MJ, Perry KW, Falcone JF, Johnson BG, Barth VN, Rash KS, et al. (December 2009). "In vitro and in vivo evidence for a lack of interaction with dopamine D2 receptors by the metabotropic glutamate 2/3 receptor agonists 1S,2S,5R,6S-2-aminobicyclohexane-2,6-bicaroxylate monohydrate (LY354740)
743:
Molinaro G, Traficante A, Riozzi B, Di Menna L, Curto M, Pallottino S, et al. (August 2009). "Activation of mGlu2/3 metabotropic glutamate receptors negatively regulates the stimulation of inositol phospholipid hydrolysis mediated by 5-hydroxytryptamine2A serotonin receptors in the frontal
419:
Monn JA, Valli MJ, Massey SM, Hansen MM, Kress TJ, Wepsiec JP, et al. (March 1999). "Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent,
534:
Moldrich RX, Jeffrey M, Talebi A, Beart PM, Chapman AG, Meldrum BS (July 2001). "Anti-epileptic activity of group II metabotropic glutamate receptor agonists (--)-2-oxa-4-aminobicyclohexane-4,6-dicarboxylate (LY379268) and (--)-2-thia-4-aminobicyclohexane-4,6-dicarboxylate (LY389795)".
455:
Rorick-Kehn LM, Johnson BG, Burkey JL, Wright RA, Calligaro DO, Marek GJ, et al. (April 2007). "Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist
656:
Greenslade RG, Mitchell SN (July 2004). "Selective action of (-)-2-oxa-4-aminobicyclohexane-4,6-dicarboxylate (LY379268), a group II metabotropic glutamate receptor agonist, on basal and phencyclidine-induced dopamine release in the nucleus accumbens shell".
1034:
613:
Cartmell J, Monn JA, Schoepp DD (March 2000). "Attenuation of specific PCP-evoked behaviors by the potent mGlu2/3 receptor agonist, LY379268 and comparison with the atypical antipsychotic, clozapine".
1027:
499:
Cai Z, Xiao F, Fratkin JD, Rhodes PG (December 1999). "Protection of neonatal rat brain from hypoxic-ischemic injury by LY379268, a Group II metabotropic glutamate receptor agonist".
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KΕodzinska A, Bijak M, Tokarski K, Pilc A (September 2002). "Group II mGlu receptor agonists inhibit behavioural and electrophysiological effects of DOI in mice".
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Seeman P, Guan HC (November 2008). "Phencyclidine and glutamate agonist LY379268 stimulate dopamine D2High receptors: D2 basis for schizophrenia".
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is a drug that is used in neuroscience research, which acts as a potent and selective agonist for the group II metabotropic glutamate receptors (
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792:"mGluR2/3 agonist LY379268 rescues NMDA and GABAA receptor level deficits induced in a two-hit mouse model of schizophrenia"
2004:
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Uys JD, LaLumiere RT (November 2008). "Glutamate: the new frontier in pharmacotherapy for cocaine addiction".
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InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1
182:
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883:"The preclinical properties of a novel group II metabotropic glutamate receptor agonist LY379268"
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selective, and systemically active agonists for group II metabotropic glutamate receptors".
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456:(-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo-hexane-4,6-dicarboxylic acid (LY404039)".
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and (-)-2-oxa-4-aminobicyclo Hexane-4,6-dicarboxylic acid (LY379268)".
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373:, which has led to research into LY-379,268 and similar compounds as
790:, Snikeris P, Matosin N, Newell KA, Huang XF, Frank E (April 2016).
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There are inconsistent findings about an additional activity as a
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1016:
353:, but is still widely used in research itself. LY-379,268 has
52:(1S,2R,5R,6R)-2-amino-4-oxabicyclohexane-2,6-dicarboxylic acid
349:, and led on to the development of the more potent compound
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The
Journal of Pharmacology and Experimental Therapeutics
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The
Journal of Pharmacology and Experimental Therapeutics
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It is derived from the older mGluR group II agonist
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365:effects in animals, and blocks the effects of
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580:CNS & Neurological Disorders Drug Targets
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2047:Glutamate metabolism/transport modulators
1954:Tooltip Metabotropic glutamate receptor 8
1855:Tooltip Metabotropic glutamate receptor 7
1783:Tooltip Metabotropic glutamate receptor 6
1679:Tooltip Metabotropic glutamate receptor 4
1530:Tooltip Metabotropic glutamate receptor 3
1372:Tooltip Metabotropic glutamate receptor 2
1186:Tooltip Metabotropic glutamate receptor 5
1072:Tooltip Metabotropic glutamate receptor 1
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2128:Drugs developed by Eli Lilly and Company
2043:Ionotropic glutamate receptor modulators
702:Pharmacology, Biochemistry, and Behavior
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7:
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1586:Pomaglumetad methionil (LY-2140023)
1438:Pomaglumetad methionil (LY-2140023)
85:
2081:. You can help Knowledge (XXG) by
14:
2061:
899:10.1111/j.1527-3458.2007.00024.x
852:10.1016/j.neuropharm.2004.08.018
671:10.1016/j.neuropharm.2004.02.015
513:10.1097/00001756-199912160-00037
220:
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1982:Positive allosteric modulators:
1933:Negative allosteric modulators:
1722:Positive allosteric modulators:
1640:Negative allosteric modulators:
1504:Negative allosteric modulators:
1447:Positive allosteric modulators:
1303:Negative allosteric modulators:
1246:Positive allosteric modulators:
1044:Metabotropic glutamate receptor
304:Key:YASVRZWVUGJELU-MDASVERJSA-N
422:Journal of Medicinal Chemistry
223:
208:
1:
2039:Receptor/signaling modulators
714:10.1016/S0091-3057(02)00845-6
549:10.1016/S0028-3908(01)00044-2
377:drugs for the treatment of
2159:
2056:
592:10.2174/187152708786927868
198:Chemical and physical data
2143:Nervous system drug stubs
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1571:LY-404,039 (pomaglumetad)
1418:LY-404,039 (pomaglumetad)
808:10.1007/s00213-016-4230-0
312:
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279:C1(2(2O1)C(=O)O)(C(=O)O)N
267:
40:
26:
2073:article relating to the
1450:JNJ-40411813 (ADX-71149)
744:cortex of living mice".
2138:MGlu3 receptor agonists
2133:MGlu2 receptor agonists
988:10.1124/jpet.109.160598
470:10.1124/jpet.106.110809
758:10.1124/mol.109.056580
746:Molecular Pharmacology
627:10.1007/s002130050072
361:, anti-addictive and
386:dopamine D2 receptor
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615:Psychopharmacology
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840:Neuropharmacology
659:Neuropharmacology
537:Neuropharmacology
507:(18): 3927β3931.
434:10.1021/jm980616n
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258:Interactive image
167:CompTox Dashboard
16:Chemical compound
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887:CNS Drug Reviews
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846:(8): 1135β1145.
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802:(8): 1349β1359.
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428:(6): 1027β1040.
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1103:Quisqualic acid
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1011:
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967:
938:(11): 819β828.
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881:Imre G (2007).
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621:(4): 423β429.
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586:(5): 482β491.
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363:anticonvulsant
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1561:Ibotenic acid
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1408:Ibotenic acid
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1250:
1247:
1243:
1240:
1238:
1235:
1233:
1232:Ibotenic acid
1230:
1228:
1225:
1223:
1220:
1218:
1215:
1213:
1210:
1208:
1205:
1203:
1200:
1198:
1195:
1192:
1191:
1189:
1184:
1175:
1169:
1166:
1164:
1161:
1159:
1156:
1154:
1151:
1149:
1148:Cyclothiazide
1146:
1144:
1141:
1139:
1136:
1133:
1132:
1129:
1126:
1124:
1121:
1119:
1116:
1114:
1111:
1109:
1106:
1104:
1101:
1099:
1098:Ibotenic acid
1096:
1094:
1091:
1089:
1086:
1084:
1081:
1078:
1077:
1075:
1070:
1061:
1058:
1056:
1052:
1048:
1045:
1038:
1033:
1031:
1026:
1024:
1019:
1018:
1015:
1005:
1001:
997:
993:
989:
985:
981:
977:
969:
966:
961:
957:
953:
949:
945:
941:
937:
933:
926:
923:
918:
914:
909:
904:
900:
896:
892:
888:
884:
877:
874:
869:
865:
861:
857:
853:
849:
845:
841:
833:
830:
825:
821:
817:
813:
809:
805:
801:
797:
793:
789:
783:
780:
775:
771:
767:
763:
759:
755:
751:
747:
739:
736:
731:
727:
723:
719:
715:
711:
707:
703:
696:
693:
688:
684:
680:
676:
672:
668:
664:
660:
652:
649:
644:
640:
636:
632:
628:
624:
620:
616:
609:
606:
601:
597:
593:
589:
585:
581:
574:
571:
566:
562:
558:
554:
550:
546:
542:
538:
530:
527:
522:
518:
514:
510:
506:
502:
495:
492:
487:
483:
479:
475:
471:
467:
463:
459:
451:
448:
443:
439:
435:
431:
427:
423:
415:
412:
406:
402:
399:
398:
394:
392:
390:
387:
382:
380:
379:schizophrenia
376:
375:antipsychotic
372:
368:
364:
360:
356:
352:
348:
343:
341:
334:
324:
317:
311:
302:
297:
293:
286:
277:
273:
266:
259:
255:
254:
252:
249:
244:
237:
235:
231:
207:
205:
201:
196:
188:
184:
180:
179:
177:
168:
164:
157:
153:
152:
150:
148:
144:
137:
133:
132:
130:
128:
124:
117:
113:
112:
110:
108:
104:
97:
93:
92:
90:
83:
79:
72:
68:
67:
65:
63:
59:
50:
46:
39:
34:
30:
25:
2083:expanding it
2068:
2035:
2034:
1992:Antagonists:
1991:
1981:
1961:
1932:
1891:Antagonists:
1890:
1862:
1809:Antagonists:
1808:
1790:
1737:Antagonists:
1736:
1721:
1686:
1639:
1598:Antagonists:
1597:
1591:Talaglumetad
1565:
1537:
1503:
1457:Antagonists:
1456:
1446:
1443:Talaglumetad
1412:
1379:
1316:Dipraglurant
1311:Basimglurant
1302:
1256:Antagonists:
1255:
1245:
1193:
1135:Antagonists:
1134:
1079:
979:
975:
968:
935:
931:
925:
890:
886:
876:
843:
839:
832:
799:
795:
782:
749:
745:
738:
705:
701:
695:
662:
658:
651:
618:
614:
608:
583:
579:
573:
540:
536:
529:
504:
500:
494:
461:
457:
450:
425:
421:
414:
383:
381:in animals.
344:
332:
331:
320:
314:
156:CHEBI:192545
1718:VU-0155,041
1643:Decoglurant
1507:Decoglurant
1341:Raseglurant
1289:Remeglurant
1274:Mavoglurant
1138:BAY 36-7620
543:(1): 8β18.
501:NeuroReport
241: gΒ·mol
71:191471-52-0
36:Identifiers
2122:Categories
1985:AZ12216052
1725:Foliglurax
1713:VU-001,171
1626:LY-341,495
1621:LY-307,452
1576:LY-487,379
1566:LY-379,268
1485:LY-341,495
1480:LY-307,452
1428:LY-566,332
1423:LY-487,379
1413:LY-379,268
1269:LY-344,545
1249:LSN2463359
1158:LY-456,236
1153:LY-367,385
1047:modulators
665:(1): 1β8.
407:References
351:LY-404,039
333:LY-379,268
246:3D model (
234:Molar mass
136:S96JF4J697
107:ChemSpider
62:CAS Number
45:IUPAC name
21:LY-379,268
2036:See also:
1970:Glutamate
1962:Agonists:
1884:LSP2-9166
1871:Glutamate
1863:Agonists:
1794:Glutamate
1791:Agonists:
1703:LSP2-9166
1690:Glutamate
1687:Agonists:
1662:Group III
1648:RO4491533
1556:Glutamate
1551:Eglumegad
1538:Agonists:
1512:RO4491533
1403:Glutamate
1398:Eglumegad
1380:Agonists:
1227:Glutamate
1202:ADX-47273
1194:Agonists:
1118:Ro67-7476
1113:Ro67-4853
1108:Ro01-6128
1093:Glutamate
1080:Agonists:
960:206519749
824:253744752
347:eglumegad
2020:UBP-1112
1936:ADX71743
1924:UBP-1112
1837:UBP-1112
1765:UBP-1112
1636:MGS-0039
1581:MGS-0028
1495:MGS-0039
1433:MGS-0028
1355:Group II
1299:SIB-1893
1294:SIB-1757
1284:NPS-2390
1168:NPS-2390
1128:Theanine
1004:23981819
996:19755662
952:18720422
917:18078428
868:22374384
860:15567423
816:26861891
774:14722003
766:19439499
730:28841684
722:12117586
687:25267021
679:15165829
643:22988081
635:10928316
600:19128205
565:26104177
557:11445181
521:10716235
486:23666836
478:17204749
442:10090786
395:See also
355:sedative
323:(verify)
96:10197984
1326:GRN-529
1321:Fenobam
1306:AZD9272
1242:VU-1545
1143:CPCCOEt
1055:Group I
932:Synapse
908:6494167
788:Engel M
239:187.151
204:Formula
116:8373484
82:PubChem
1929:XAP044
1866:AMN082
1546:DCG-IV
1541:CBiPES
1500:PCCG-4
1393:DCG-IV
1388:CBiPES
1002:
994:
958:
950:
915:
905:
866:
858:
822:
814:
772:
764:
728:
720:
685:
677:
641:
633:
598:
563:
555:
519:
484:
476:
440:
272:SMILES
2077:is a
2069:This
1947:mGluR
1904:MMPIP
1848:mGluR
1776:mGluR
1708:PHCCC
1672:mGluR
1616:HYDIA
1606:CECXG
1601:APICA
1523:mGluR
1475:HYDIA
1465:CECXG
1460:APICA
1365:mGluR
1264:DMeOB
1207:CDPPB
1179:mGluR
1123:VU-71
1065:mGluR
1000:S2CID
956:S2CID
864:S2CID
820:S2CID
770:S2CID
726:S2CID
683:S2CID
639:S2CID
561:S2CID
482:S2CID
401:HYDIA
337:mGluR
292:InChI
248:JSmol
147:ChEBI
2079:stub
2071:drug
2015:MTPG
2010:MSOP
2005:MPPG
2000:MAP4
1995:CPPG
1978:-AP4
1965:DCPG
1919:MTPG
1914:MSOP
1909:MPPG
1899:MAP4
1894:CPPG
1879:-AP4
1832:MTPG
1827:MSOP
1822:MPPG
1817:MAP4
1812:CPPG
1802:-AP4
1760:MTPG
1755:MSOP
1750:MPPG
1745:MAP4
1740:CPPG
1730:MPEP
1698:-AP4
1631:MCPG
1611:EGLU
1490:MCPG
1470:EGLU
1383:BINA
1336:MTEP
1331:MPEP
1279:MCPG
1259:CTEP
1222:DHPG
1212:CHPG
1197:ACPD
1163:MCPG
1088:DHPG
1083:ACPD
992:PMID
948:PMID
913:PMID
856:PMID
812:PMID
762:PMID
718:PMID
675:PMID
631:PMID
596:PMID
553:PMID
517:PMID
474:PMID
438:PMID
369:and
127:UNII
1217:DFB
984:doi
980:331
940:doi
903:PMC
895:doi
848:doi
804:doi
800:233
754:doi
710:doi
667:doi
623:doi
619:148
588:doi
545:doi
509:doi
466:doi
462:321
430:doi
371:DOI
367:PCP
342:).
339:2/3
172:EPA
86:CID
2124::
2045:β’
2041:β’
1980:;
1931:;
1720:;
1638:;
1502:;
1445:;
1301:;
1244:;
998:.
990:.
978:.
954:.
946:.
936:62
934:.
911:.
901:.
891:13
889:.
885:.
862:.
854:.
844:47
842:.
818:.
810:.
798:.
794:.
768:.
760:.
750:76
748:.
724:.
716:.
706:73
704:.
681:.
673:.
663:47
661:.
637:.
629:.
617:.
594:.
582:.
559:.
551:.
541:41
539:.
515:.
505:10
503:.
480:.
472:.
460:.
436:.
426:42
424:.
391:.
357:,
2110:e
2103:t
2096:v
2085:.
1976:L
1949:8
1877:L
1850:7
1800:L
1778:6
1696:L
1674:4
1525:3
1367:2
1181:5
1067:1
1036:e
1029:t
1022:v
1006:.
986::
962:.
942::
919:.
897::
870:.
850::
826:.
806::
776:.
756::
732:.
712::
689:.
669::
645:.
625::
602:.
590::
584:7
567:.
547::
523:.
511::
488:.
468::
444:.
432::
250:)
227:5
224:O
221:N
218:9
215:H
212:7
209:C
174:)
170:(
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