244:
221:
118:
143:
250:
149:
1186:
Marion V, Stutzmann F, GĂ©rard M, De Melo C, Schaefer E, Claussmann A, et al. (May 2012). "Exome sequencing identifies mutations in LZTFL1, a BBSome and smoothened trafficking regulator, in a family with Bardet--Biedl syndrome with situs inversus and insertional polydactyly".
1230:
Kiss H, Kedra D, Kiss C, Kost-Alimova M, Yang Y, Klein G, et al. (April 2001). "The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3".
257:
156:
1005:
664:
645:
79:
998:
1093:
1075:
1551:
243:
895:
888:
220:
1004:
Identified as the gene on chromosome 3 at location 3p21.31 responsible for mediating an associated with genetic susceptibility to
1062:
1041:
1058:
142:
117:
1037:
59:
256:
155:
249:
148:
978:
1111:
709:
67:
1561:
690:
994:
1491:
1380:
Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, et al. (October 2020).
1328:
131:
46:
846:
842:
795:
791:
783:
779:
1527:
1362:
1212:
91:
1112:"LZTFL1 leucine zipper transcription factor like 1 [Homo sapiens (human)] - Gene - NCBI"
977:
This protein regulates protein trafficking to the ciliary membrane through interaction with the
871:
850:
816:
787:
1556:
1519:
1460:
1411:
1354:
1297:
1248:
1204:
1168:
39:
1509:
1499:
1450:
1442:
1429:
Downes DJ, Cross AR, Hua P, Roberts N, Schwessinger R, Cutler AJ, et al. (2021-11-04).
1401:
1393:
1344:
1336:
1287:
1279:
1240:
1196:
1158:
1148:
336:
267:
211:
166:
87:
311:
1135:
Seo S, Zhang Q, Bugge K, Breslow DK, Searby CC, Nachury MV, et al. (November 2011).
1495:
1332:
1455:
1430:
1406:
1381:
1349:
1316:
1292:
1267:
1163:
1136:
1315:
Niemi ME, Karjalainen J, Liao RG, Neale BM, Daly M, Ganna A, et al. (July 2021).
579:
574:
558:
553:
537:
532:
527:
1545:
1531:
1514:
1366:
514:
1216:
71:
1137:"A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened"
1013:
329:
108:
1480:"The major genetic risk factor for severe COVID-19 is inherited from Neanderthals"
1283:
1200:
1153:
95:
1431:"Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus"
1098:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1080:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1446:
1340:
412:
1504:
1479:
228:
125:
75:
993:
gene are associated with Bardet-Biedl syndrome, and the gene also acts as a
959:
609:
472:
350:
295:
282:
194:
181:
83:
1523:
1464:
1415:
1358:
1301:
1268:"Tumor-suppressive functions of leucine zipper transcription factor-like 1"
1252:
1244:
1208:
1172:
1012:
respiratory failure. The DNA segment conferring the risk is inherited from
1397:
1382:"Genomewide Association Study of Severe Covid-19 with Respiratory Failure"
935:
930:
1009:
919:
754:
735:
1266:
Wei Q, Zhou W, Wang W, Gao B, Wang L, Cao J, et al. (April 2010).
955:
721:
676:
903:
631:
594:
590:
966:
63:
580:
negative regulation of protein localization to ciliary membrane
319:
575:
negative regulation of protein localization to cilium
484:
1317:"Mapping the human genetic architecture of COVID-19"
864:
835:
809:
772:
50:, BBS17, leucine zipper transcription factor like 1
1054:
1052:
1050:
1033:
1031:
1029:
266:
165:
16:Protein-coding gene in the species Homo sapiens
1059:GRCm38: Ensembl release 89: ENSMUSG00000025245
8:
1038:GRCh38: Ensembl release 89: ENSG00000163818
948:Leucine zipper transcription factor like 1
605:
510:
307:
206:
103:
1513:
1503:
1454:
1405:
1348:
1291:
1162:
1152:
1025:
20:
271:
232:
227:
170:
129:
124:
7:
1478:Zeberg H, Pääbo S (November 2020).
1386:The New England Journal of Medicine
861:
832:
806:
769:
745:
726:
700:
681:
655:
636:
538:protein-containing complex binding
489:
407:
345:
324:
14:
999:epithelial-mesenchymal transition
962:and in humans is encoded by the
255:
248:
242:
219:
154:
147:
141:
116:
473:More reference expression data
1:
1284:10.1158/0008-5472.CAN-09-3826
1201:10.1136/jmedgenet-2012-100737
240:
139:
1154:10.1371/journal.pgen.1002358
954:is a ubiquitously expressed
381:Epithelium of choroid plexus
1552:Genes on human chromosome 3
1189:Journal of Medical Genetics
981:(BBS) complex of proteins.
1578:
1447:10.1038/s41588-021-00955-3
1341:10.1038/s41586-021-03767-x
1515:21.11116/0000-0007-0F26-F
1505:10.1038/s41586-020-2818-3
1094:"Mouse PubMed Reference:"
1076:"Human PubMed Reference:"
934:
929:
925:
918:
902:
896:Chr 9: 123.52 – 123.55 Mb
883:
868:
839:
828:
813:
776:
765:
752:
748:
733:
729:
720:
707:
703:
688:
684:
675:
662:
658:
643:
639:
630:
615:
608:
604:
588:
533:identical protein binding
513:
509:
497:
492:
483:
470:
419:
410:
361:bronchial epithelial cell
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
397:tendon of biceps brachii
958:which localizes to the
889:Chr 3: 45.82 – 45.92 Mb
1245:10.1006/geno.2000.6498
997:through regulation of
1398:10.1056/NEJMoa2020283
985:Clinical significance
979:Bardet-Biedl syndrome
385:middle temporal gyrus
1116:www.ncbi.nlm.nih.gov
451:olfactory epithelium
273:9 F4|9 74.36 cM
234:Chromosome 9 (mouse)
132:Chromosome 3 (human)
1496:2020Natur.587..610Z
1333:2021Natur.600..472C
439:seminiferous tubule
710:ENSMUSG00000025245
568:Biological process
547:Cellular component
521:Molecular function
96:LZTFL1 - orthologs
1490:(7835): 610–612.
1441:(11): 1606–1615.
1392:(16): 1522–1534.
1327:(7889): 472–477.
989:Mutations in the
945:
944:
941:
940:
914:
913:
879:
878:
858:
857:
824:
823:
803:
802:
761:
760:
742:
741:
716:
715:
697:
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671:
670:
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651:
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500:
479:
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404:
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301:
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200:
1569:
1536:
1535:
1517:
1507:
1475:
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1426:
1420:
1419:
1409:
1377:
1371:
1370:
1352:
1312:
1306:
1305:
1295:
1278:(7): 2942–2950.
1263:
1257:
1256:
1227:
1221:
1220:
1183:
1177:
1176:
1166:
1156:
1147:(11): e1002358.
1132:
1126:
1125:
1123:
1122:
1108:
1102:
1101:
1090:
1084:
1083:
1072:
1066:
1056:
1045:
1035:
995:tumor suppressor
927:
926:
898:
891:
874:
862:
853:
833:
829:RefSeq (protein)
819:
807:
798:
770:
746:
727:
701:
682:
656:
637:
606:
511:
490:
475:
447:secondary oocyte
435:genital tubercle
415:
413:Top expressed in
408:
377:endothelial cell
373:caput epididymis
369:Brodmann area 23
353:
351:Top expressed in
346:
325:
308:
298:
285:
274:
259:
252:
246:
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223:
207:
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173:
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98:
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42:
21:
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1566:
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1540:
1539:
1477:
1476:
1472:
1435:Nature Genetics
1428:
1427:
1423:
1379:
1378:
1374:
1314:
1313:
1309:
1272:Cancer Research
1265:
1264:
1260:
1229:
1228:
1224:
1185:
1184:
1180:
1134:
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1129:
1120:
1118:
1110:
1109:
1105:
1092:
1091:
1087:
1074:
1073:
1069:
1057:
1048:
1036:
1027:
1022:
987:
975:
936:View/Edit Mouse
931:View/Edit Human
894:
887:
884:Location (UCSC)
870:
849:
845:
841:
815:
794:
790:
786:
782:
778:
691:ENSG00000163818
584:
563:
542:
528:protein binding
471:
462:
457:
453:
449:
445:
441:
437:
433:
429:
425:
411:
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387:
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379:
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371:
367:
363:
349:
293:
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210:Gene location (
192:
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152:
130:
107:Gene location (
58:
45:
38:
17:
12:
11:
5:
1575:
1573:
1565:
1564:
1562:Human genetics
1559:
1554:
1544:
1543:
1538:
1537:
1470:
1421:
1372:
1307:
1258:
1222:
1195:(5): 317–321.
1178:
1127:
1103:
1085:
1067:
1046:
1024:
1023:
1021:
1018:
1008:infection and
986:
983:
974:
971:
950:also known as
943:
942:
939:
938:
933:
923:
922:
916:
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911:
909:
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774:
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724:
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431:tail of embryo
428:
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382:
378:
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366:
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342:
341:
333:
322:
316:
315:
312:RNA expression
304:
303:
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291:
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286:
278:
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112:
100:
99:
56:
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51:
43:
35:
34:
30:
29:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
1574:
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1533:
1529:
1525:
1521:
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1501:
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1373:
1368:
1364:
1360:
1356:
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1330:
1326:
1322:
1318:
1311:
1308:
1303:
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1234:
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1223:
1218:
1214:
1210:
1206:
1202:
1198:
1194:
1190:
1182:
1179:
1174:
1170:
1165:
1160:
1155:
1150:
1146:
1142:
1141:PLOS Genetics
1138:
1131:
1128:
1117:
1113:
1107:
1104:
1099:
1095:
1089:
1086:
1081:
1077:
1071:
1068:
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1055:
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1047:
1043:
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1034:
1032:
1030:
1026:
1019:
1017:
1015:
1011:
1007:
1002:
1000:
996:
992:
984:
982:
980:
972:
970:
968:
965:
961:
957:
953:
949:
937:
932:
928:
924:
921:
917:
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908:
905:
901:
897:
893:
890:
886:
882:
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873:
867:
863:
860:
854:
852:
848:
844:
838:
834:
831:
827:
820:
818:
812:
808:
805:
799:
797:
793:
789:
785:
781:
775:
771:
768:
766:RefSeq (mRNA)
764:
757:
756:
751:
747:
744:
738:
737:
732:
728:
725:
723:
719:
712:
711:
706:
702:
699:
693:
692:
687:
683:
680:
678:
674:
667:
666:
661:
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654:
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642:
638:
635:
633:
629:
626:
623:
621:
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614:
611:
607:
603:
596:
592:
587:
581:
578:
576:
573:
572:
570:
567:
566:
560:
557:
555:
552:
551:
549:
546:
545:
539:
536:
534:
531:
529:
526:
525:
523:
520:
519:
516:
515:Gene ontology
512:
508:
496:
491:
488:
486:
482:
474:
469:
459:parotid gland
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
396:
392:
388:
384:
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376:
372:
368:
364:
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321:
317:
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222:
217:
213:
208:
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196:
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183:
178:
168:
164:
157:
150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
19:
1487:
1483:
1473:
1438:
1434:
1424:
1389:
1385:
1375:
1324:
1320:
1310:
1275:
1271:
1261:
1239:(1): 10–19.
1236:
1232:
1225:
1192:
1188:
1181:
1144:
1140:
1130:
1119:. Retrieved
1115:
1106:
1097:
1088:
1079:
1070:
1014:Neanderthals
1003:
990:
988:
976:
963:
951:
947:
946:
869:
847:NP_001263308
843:NP_001263307
840:
814:
796:NM_001386452
792:NM_001386451
784:NM_001276379
780:NM_001276378
777:
753:
734:
708:
689:
663:
644:
624:
619:
427:spermatocyte
393:right testis
335:
328:
294:123,546,762
281:123,523,481
55:External IDs
18:
389:left testis
193:45,916,042
180:45,823,316
33:Identifiers
1546:Categories
1121:2021-08-17
1065:, May 2017
1044:, May 2017
1020:References
1006:SARS-CoV-2
339:(ortholog)
76:HomoloGene
1532:222148977
1367:235776838
960:cytoplasm
872:NP_201579
851:NP_065080
817:NM_033322
788:NM_020347
610:Orthologs
554:cytoplasm
423:spermatid
84:GeneCards
1557:Proteins
1524:32998156
1465:34737427
1416:32558485
1359:34237774
1302:20233871
1253:11352561
1233:Genomics
1217:33467850
1209:22510444
1173:22072986
1061:–
1040:–
1010:COVID-19
973:Function
920:Wikidata
589:Sources:
1492:Bibcode
1456:7611960
1407:7315890
1350:8674144
1329:Bibcode
1293:2848875
1164:3207910
1063:Ensembl
1042:Ensembl
956:protein
722:UniProt
677:Ensembl
616:Species
595:QuickGO
559:cytosol
314:pattern
172:3p21.31
72:1934860
40:Aliases
1530:
1522:
1484:Nature
1463:
1453:
1414:
1404:
1365:
1357:
1347:
1321:Nature
1300:
1290:
1251:
1215:
1207:
1171:
1161:
991:LZTFL1
964:LZTFL1
952:LZTFL1
906:search
904:PubMed
755:Q9JHQ5
736:Q9NQ48
632:Entrez
485:BioGPS
455:thymus
443:zygote
88:LZTFL1
64:606568
47:LZTFL1
24:LZTFL1
1528:S2CID
1363:S2CID
1213:S2CID
665:93730
646:54585
625:Mouse
620:Human
591:Amigo
365:sperm
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
80:41368
1520:PMID
1461:PMID
1412:PMID
1355:PMID
1298:PMID
1249:PMID
1205:PMID
1169:PMID
967:gene
320:Bgee
268:Band
229:Chr.
167:Band
126:Chr.
60:OMIM
1510:hdl
1500:doi
1488:587
1451:PMC
1443:doi
1402:PMC
1394:doi
1390:383
1345:PMC
1337:doi
1325:600
1288:PMC
1280:doi
1241:doi
1197:doi
1159:PMC
1149:doi
493:n/a
290:End
189:End
92:OMA
68:MGI
1548::
1526:.
1518:.
1508:.
1498:.
1486:.
1482:.
1459:.
1449:.
1439:53
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