289:
302:
439:
28:
727:
Collection to select a strain able to survive to the human intestinal tract.”. Adherence to mucus and human epithelial cells and cell lines and the ability to reduce pathogen adhesion to surfaces is scientifically proven by the research "Influence of
Gastrointestinal System Conditions on Adhesion of
494:
the author described the discovery as follows: "In
Bulgaria, the home of this bacillus, the majority of the natives live to age considerably in excess of what is recognized as the term of life among Western nations, an inquiry has shown that in the Eastern part of Southern Europe, among a population
284:
flower is found in
European mountainous regions, and blooms between January and May, when temperatures can fall below freezing in the region. Thus, GLB44 is also naturally capable of surviving in below-freezing temperatures, allowing GLB44 to survive in plant-based aliments stored at refrigerator
495:
of about 3,000,000, there were more than 3,000 centenarians found performing duties which would not be assigned to a man of 65 years of age elsewhere. It is quite common to find among the peasants who live to such a large extent upon soured milk individuals of 110 and 120 years of age."
596:. GLB44 does not increase the risk of tooth decay due to its inability to live in the human mouth, an advantage versus other probiotics that contain any of the following lactobacilli that live naturally in the human mouth and could contribute to the tooth decay:
654:) has presented on their website the following guideline: “Guidance for Industry on Complementary and Alternative Medicine Products and Their Regulation by the Food and Drug Administration” In this article, the definition of "Probiotics" is twofold: 1) live
347:
does not have any interference with mammalian organs, only flowers, leaves and juices. This is important for multiple reasons such as the fact that there is some scientific evidence that probiotics growing in the human mouth naturally could accelerate
576:
GLB44 is a safe product, without limitations of the quantity consumed. It is also recommendable for the elderly as it helps reduce infections such as the common cold, as well as for young children (i.e., when they suffer from acute diarrhea).
1325:
Moro-GarcĂa, MA; Alonso-Arias, R; Baltadjieva, M; Fernández BenĂtez, C; Fernández
Barrial, MA; DĂaz Ruisánchez, E; Alonso Santos, R; Alvarez Sánchez, M; Saavedra Miján, J; LĂłpez-Larrea, C (August 2013).
581:, published by Harvard Medical School, recommends a GLB44 dose range of between 1 and 10 billion colony forming units (CFU) per day, the amount contained in a capsule or two several days a week.
1920:
661:
that beneficially affect the host by improving its intestinal microbial; 2) live microorganisms which, when consumed in adequate amounts of food, confer a health benefit on the host.
288:
1413:"Title 21--Food And Drugs Chapter I--Food And Drug Administration Department Of Health And Human Services Subchapter B--Food For Human Consumption Part 131 Milk And Cream"
668:
website, "Guidelines for
Evaluation of Probiotics in Food", has outlined more specific criteria for the definition of effective probiotic based on the following criteria:
442:
Living in a mountain village of
Bulgaria with her son who was 101 years old, Vasilka's age was not unusual for her community, which, of note, consumed yogurt containing
147:
1680:
Food and
Agriculture Organization of the United Nations, World Health Organization (2002) "Guidelines for the Evaluation of Probiotics" available on the FDA website:
482:
Confirmed in His Theory of Long Life,” highlighting villager
Vasilka, age 126, as the longest living person in the world. In Bulgarian communities there were 3,000
1693:
Vázquez, C; Botella-Carretero, JI; GarcĂa-Albiach, R; Pozuelo, MJ; RodrĂguez-Baños, M; Baquero, F; Baltadjieva, MA; del Campo, R (Jul–Aug 2013). "Screening in a
1412:
1933:
1833:
88:
941:
498:
There is a complex interplay between the probiotic bacteria and the body's immune system in the large intestine, where bacteria stimulate the body's own
1881:
1383:
1907:
584:
GLB44 is not a bacterium that can live naturally in the human mouth, as presented by the Human Oral
Microbiome Database. A study conducted by the
1609:
Chen T, Dewhirst F, Izard J, Paster J, Tanner A, Wade W (2014) "Human Oral
Microbiome Database" available on the electronic website: www.homd.org
1565:
1681:
38:
719:
successfully passes through the human intestinal tract, maintaining its viability: “Survival of Yogurt Bacteria in the Human Gut” and “
57:
1632:
75:
1658:"Guidance for Industry on Complementary and Alternative Medicine Products and Their Regulation by the Food and Drug Administration"
1149:
Elli, M; Callegari, ML; Ferrari, S; Bessi, E; Cattivelli, D; Soldi, S; Morelli, L; Goupil Feuillerat, N; Antoine, JM (July 2006).
1101:
1912:
146:
910:
665:
651:
647:
547:
531:
384:
851:
551:
359:
in the growth solution, GLB44 has no major allergens as part of its growth medium. For example, the growth medium for
53:
502:
to inhibit the pathogenic bacteria. In a controlled study, 61 elderly volunteers, after 6 months of a daily dose of
454:
was discovered more than a century ago, the result of a study into the unusual longevity of mountain villagers in
1961:
1938:
240:
515:
1657:
1134:
1113:
273:
flower; it is the only known strain of this subspecies that has a vegan origin (not from yogurt) and it is a
327:
321:
430:
299v all have scientific records of their ability to pass successfully through the gastrointestinal tract.
301:
1791:
1051:
Schwendicke, F; Dörfer, C; Kneist, S; Meyer-Lueckel, H; Paris, S (2014). "Cariogenic effects of probiotic
1254:
592:
is the biggest culprit for tooth decay, various lactobacilli are also associated with the progression of
491:
414:
which is now over 109 years since it was scientifically isolated. There are certain similarities between
1682:
https://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-rpt0282-tab-03-ref-19-joint-faowho-vol219.pdf
519:
1925:
438:
887:. Institute of Biodiversity and Ecosystem Research – Bulgarian Academy of Science Electronic Database.
514:
subsets that are less differentiated. The probiotic group also showed decreased concentrations of the
379:. The fact that GLB44 is grown in vegetable juice means GLB44 does not contain any of the seven major
1162:
715:
Resistance to gastric acid and bile acid are scientifically presented in the following studies where
559:
339:
712:
as an example of an effective probiotic with suitable scientific substantiation of health benefits.
486:
from a population of 3 million – six times higher than the number of centenarians per capita in the
689:
585:
479:
1000:
species and the demographic and microbiologic characteristics of women colonized by these species"
510:, an improvement in the parameters defining the immune risk profile (IRP), and an increase in the
1080:
539:
154:
1855:
1771:
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1021:
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307:
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119:
1301:
49:
1761:
1746:"Influence of gastrointestinal system conditions on adhesion of exopolysaccharide-producing
1710:
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1355:
1347:
1223:
1207:
1178:
1170:
1064:
1011:
968:
820:
658:
213:
114:
1440:"Reducing the risk of infection in the elderly by dietary intake of yoghurt fermented with
1284:
1102:
http://store.drhyman.com/Store/Show/ListAlphabetically/378/Culturelle-with-Lactobacillus-GG
1228:
1211:
463:
333:
201:
1041:
GLB44 patent pending status as reported on the branded product website: www.proviotic.com
1212:"Survival of lactic acid bacteria in the human stomach and adhesion to intestinal cells"
1166:
1530:
1491:
1360:
1327:
1183:
1150:
467:
1955:
825:
796:
499:
487:
226:
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1860:
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876:
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are extracted from the feaces of newborns, while others, such as some strains of
1894:
1827:
1438:
Makino, S; Ikegami, S; Kume, A; Horiuchi, H; Sasaki, H; Orii, N (October 2010).
349:
1714:
1701:
collection to select a strain able to survive to the human intestinal tract".
1620:
1464:
1439:
1351:
917:
1818:
1775:
1722:
506:, responded to the intake of probiotic with an increase in the percentage of
1868:
1627:(4th ed.). Galveston: University of Texas Medical Branch at Galveston.
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There are also numerous studies that outline the antimicrobial activity of
1520:
1237:
1135:
https://www.fda.gov/downloads/Food/ResourcesForYou/Consumers/UCM220117.pdf
980:
1812:
1665:
U.S. Department of Health and Human Services Food and Drug Administration
1174:
1100:
Mark Hyman (2014) "The Health Living Store" as available on the website:
695:
507:
455:
356:
165:
124:
795:
Michaylova, M; Minkova, S; Kimura, K; Sasaki, T; Isawa, K (April 2007).
1886:
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593:
388:
189:
1899:
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1311:. U.S. Department of Commerce Economics and Statistics Administration.
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972:
737:
555:
511:
392:
376:
368:
364:
98:
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1016:
995:
1566:"Benefit of Probiotics: Should you take a daily dose of bacteria?"
682:
437:
300:
287:
1500:
B-30892 can inhibit cytotoxic effects and adhesion of pathogenic
470:
wrote an overview article about the new discovery and the use of
331:
which are originally extracted from the human mouth. Others like
543:
1789:
97:
is a bacterial subspecies traditionally isolated from European
21:
1384:"CRN List of Dietary Ingredients "Grandfathered" under DSHEA"
1123:. The US Food and Drug Administration Center for Food Safety
1289:(1911 revised ed.). New York: The Knickerbocker Press.
1490:
Banerjee, Pratik; Merkel, Glenn J; Bhunia, Arun K (2009).
959:
in the feces of newborns delivered by cesarean section".
410:
Another major difference is the safety track record of
344:
45:
1621:"Microbiology of Dental Decay and Periodontal Disease"
1744:
Darilmaz, D; AslımII B; SuludereII Z; Akca G (2011).
994:
Antonio, MA; Hawes, SE; Hillier, SL (December 1999).
1336:
8481 enhances systemic immunity in elderly subjects"
554:
mandates that in the US, for a product to be called
56:, and by adding encyclopedic content written from a
1798:
708:The authors of this guideline specifically outline
1255:"Metchnikoff Confirmed In His Theory Of Long Life"
955:Bezirtzoglou, E; Romond, C (1990). "Occurrence of
305:The largest area in green, numbered "1" shows the
747:against potentially pathogenic bacteria such as
908:299v as available on the manufacturer website:
1151:"Survival of yogurt bacteria in the human gut"
418:GLB44 and some other probiotics. For example,
117:, because it was isolated from the leaves of
8:
1605:
1603:
1559:
1557:
1555:
1553:
1551:
1549:
685:and/or human epithelial cells and cell lines
530:Due to more than a century of safe use, the
1834:Lactobacillus delbrueckii subsp. bulgaricus
1676:
1674:
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1599:
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1587:
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1583:
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1302:"Centenarians: 2010, Special Census Report"
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1142:
688:Antimicrobial activity against potentially
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558:, it must contain two specific strains of
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131:
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1359:
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1182:
1015:
885:Red Data Book of the Republic of Bulgaria
824:
790:
788:
786:
784:
76:Learn how and when to remove this message
1656:US Food and Drug Administration (2006).
1419:. US Food and Drug Administration (2013)
1393:. National Nutritional Foods Association
1391:Council for Responsible Nutrition (1998)
588:uncovered that while a bacterium called
269:GLB44 is derived from the leaves of the
780:
1155:Applied and Environmental Microbiology
940:: CS1 maint: archived copy as title (
933:
642:GLB44 and the definition of probiotics
37:contains content that is written like
1564:Harvard Women's Health Watch (2005).
343:, come from the human vaginal canal.
7:
1926:lactobacillus-delbrueckii-bulgaricus
852:"Galanthus alpinus [Sosn. ]"
797:"Isolation and characterization of
664:Another guideline presented on the
367:, which contains a small amount of
1004:The Journal of Infectious Diseases
14:
1568:. from Harvard University Website
1229:10.3168/jds.S0022-0302(87)79974-3
355:While many probiotics have major
1452:The British Journal of Nutrition
826:10.1111/j.1574-6968.2007.00631.x
26:
1767:10.1590/S1516-89132011000500009
1055:GG in a dental biofilm model".
996:"The identification of vaginal
387:requires additional labelling:
1:
1210:; Goldin, BR (January 1987).
875:Peev D, Vladimirov V (2013).
672:Resistance to gastric acidity
728:exopolysaccharide-producing
648:Food and Drug Administration
579:Harvard Women's Health Watch
548:Generally Recognized as Safe
542:" status, with an automatic
385:Food and Drug Administration
1619:Loesche, Walter J. (1996).
1328:"Oral supplementation with
1283:Douglas, Loudon M. (1911).
570:, as regulated by the FDA.
552:Code of Federal Regulations
1978:
1800:Lactobacillus delbrueckii
1623:. In Baron, Samuel (ed.).
1300:Meyer, J (December 2012).
807:Streptococcus thermophilus
568:Streptococcus thermophilus
1758:Braz. Arch. Biol. Technol
1748:Lactobacillus delbrueckii
1715:10.3305/nh.2013.28.4.6540
1695:Lactobacillus delbrueckii
1494:Lactobacillus delbrueckii
1465:10.1017/S000711451000173X
1442:Lactobacillus delbrueckii
1352:10.1007/s11357-012-9434-6
1330:Lactobacillus delbrueckii
1286:The Bacillus of Long Life
856:citesbulbs.myspecies.info
813:FEMS Microbiology Letters
799:Lactobacillus delbrueckii
730:Lactobacillus delbrueckii
721:Lactobacillus delbrueckii
516:pro-inflammatory cytokine
375:GG has a small amount of
315:GLB44 differs from other
155:Scientific classification
153:
144:
134:
90:Lactobacillus delbrueckii
1754:strains to caco-2 cells"
1216:Journal of Dairy Science
809:from plants in Bulgaria"
564:Lactobacillus bulgaricus
136:Lactobacillus bulgaricus
104:Lactobacillus bulgaricus
1760:. 54, n.5 (5): 917–26.
1053:Lactobacillus rhamnosus
906:Lactobacillus plantarum
16:Subspecies of bacterium
1703:Nutricion Hospitalaria
1417:FDA Website (21CFR131)
961:Biology of the Neonate
466:in 1905. In 1912, the
447:
403:, fish, or crustacean
312:
298:
1521:10.1186/1757-4749-1-8
1502:Clostridium difficile
520:antimicrobial peptide
441:
304:
291:
255:L. d. bulgaricus
123:(common snowdrop) in
58:neutral point of view
1625:Medical Microbiology
1175:10.1128/AEM.02950-05
904:Goran Moulin (2010)
698:adhesion to surfaces
560:lactic acid bacteria
478:in Bulgaria titled “
446:as a dietary staple.
311:species distribution
1167:2006ApEnM..72.5113E
1133:, Website Content:
690:pathogenic bacteria
586:University of Texas
518:IL-8 but increased
464:Dr. Stamen Grigorov
383:for which the U.S.
265:General information
241:L. delbrueckii
110:differs from other
50:promotional content
1309:U.S. Census Bureau
1264:. January 21, 1912
1262:The New York Times
704:hydrolase activity
694:Ability to reduce
448:
313:
299:
52:and inappropriate
1949:
1948:
1792:Taxon identifiers
1069:10.1159/000355907
973:10.1159/000243275
879:Galanthus nivalis
550:). Moreover, the
308:Galanthus nivalis
294:Galanthus nivalis
262:
261:
120:Galanthus nivalis
86:
85:
78:
1969:
1962:Lactobacillaceae
1942:
1941:
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1916:
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1504:to Caco-2 cells"
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916:. Archived from
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902:
889:
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872:
866:
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862:
848:
839:
838:
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792:
659:food supplements
214:Lactobacillaceae
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1458:(7): 998–1006.
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957:Bifidobacterium
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911:"Archived copy"
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892:
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644:
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334:Bifidobacterium
328:L. rhamnosus GG
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202:Lactobacillales
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1709:(4): 1227–35.
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1346:(4): 1311–26.
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634:L. salivarius.
598:L. acidophilus
527:
524:
492:In the article
468:New York Times
435:
432:
412:L. bulgaricus,
363:299v includes
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1161:(7): 5113–7.
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1063:(3): 186–92.
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1036:
1032:
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1023:
1018:
1013:
1010:(6): 1950–6.
1009:
1005:
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998:Lactobacillus
990:
987:
982:
978:
974:
970:
967:(5): 247–51.
966:
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923:on 2010-08-20
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745:L. bulgaricus
741:
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718:
717:L. bulgaricus
713:
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710:L. bulgaricus
703:
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681:Adherence to
680:
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640:L. bulgaricus
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541:
537:
536:L. bulgaricus
533:
526:Safety of use
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505:
504:L. bulgaricus
501:
500:immune system
496:
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489:
488:United States
485:
481:
477:
476:L. bulgaricus
474:yogurts with
473:
469:
465:
461:
460:L. bulgaricus
458:(thus called
457:
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452:L. bulgaricus
445:
444:L. bulgaricus
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420:L. bulgaricus
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41:
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35:This article
33:
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1624:
1614:
1570:. Retrieved
1511:
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1421:. Retrieved
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1395:. Retrieved
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1329:
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1285:
1278:
1266:. Retrieved
1261:
1219:
1215:
1206:Conway, PL;
1201:
1158:
1154:
1125:. Retrieved
1120:
1114:"Food Facts"
1108:
1060:
1056:
1052:
1046:
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1003:
997:
989:
964:
960:
956:
950:
925:. Retrieved
918:the original
905:
884:
878:
870:
859:. Retrieved
855:
819:(1): 160–9.
816:
812:
806:
802:
798:
771:and others.
769:C. difficile
768:
764:
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742:
733:
729:
724:
720:
716:
714:
709:
707:
663:
645:
639:
633:
630:L. rhamnosus
629:
625:
621:
618:L. paracasei
617:
613:
610:L. fermentum
609:
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601:
597:
589:
583:
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572:
567:
563:
535:
534:has granted
529:
503:
497:
484:centenarians
475:
459:
451:
449:
443:
428:L. plantarum
427:
424:L. rhamnosus
423:
419:
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411:
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373:L. rhamnosus
372:
361:L. plantarum
360:
354:
338:
332:
326:
322:L. plantarum
320:
314:
306:
292:
279:
268:
254:
253:
249:Subspecies:
239:
225:
138:
135:
129:
118:
111:
107:
103:
102:
93:
89:
87:
72:
66:October 2022
63:
48:by removing
44:Please help
36:
18:
1895:iNaturalist
1828:Wikispecies
1448:OLL1073R-1"
1222:(1): 1–12.
1208:Gorbach, SL
1121:(June 2010)
765:B. subtilis
736:strains to
622:L plantarum
540:grandfather
480:Metchnikoff
399:, peanuts,
350:tooth decay
1804:bulgaricus
1752:bulgaricus
1699:bulgaricus
1498:bulgaricus
1446:bulgaricus
1334:bulgaricus
927:2014-06-03
861:2023-03-11
803:bulgaricus
775:References
761:V. cholera
753:Salmonella
734:bulgaricus
725:bulgaricus
678:resistance
626:L. reuteri
614:L. gasseri
450:The first
317:probiotics
94:bulgaricus
46:improve it
1776:1516-8913
1723:0212-1611
757:S. aureus
702:Bile salt
676:Bile acid
656:microbial
646:The U.S.
602:L. brevis
590:S. mutans
472:fermented
405:shellfish
401:tree nuts
381:allergens
357:allergens
340:L. brevis
275:probiotic
235:Species:
178:Bacillota
1956:Category
1813:Wikidata
1731:23889646
1643:21413316
1540:19397787
1514:(1): 8.
1474:20487575
1370:22645023
1193:16820518
1085:11641425
1077:24480927
1026:10558952
936:cite web
835:17257163
696:pathogen
606:L. casei
546:status (
508:NK cells
456:Bulgaria
325:299v or
319:such as
282:snowdrop
271:snowdrop
209:Family:
173:Phylum:
166:Bacteria
161:Domain:
125:Bulgaria
1887:3227306
1843:BacDive
1819:Q262677
1750:subsp.
1697:subsp.
1531:2680912
1361:3705123
1332:subsp.
1238:3106442
1184:1489325
1163:Bibcode
981:2076442
749:E. Coli
740:Cells"
732:subsp.
723:subsp.
594:lesions
522:hBD-2.
490:today.
434:History
426:GG and
389:lactose
297:flowers
221:Genus:
197:Order:
190:Bacilli
185:Class:
115:strains
99:yogurts
92:subsp.
1913:969493
1900:205934
1874:LACBBU
1802:subsp.
1774:
1729:
1721:
1667:. FDA.
1641:
1631:
1572:26 May
1538:
1528:
1472:
1423:31 May
1397:31 May
1368:
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1268:30 May
1236:
1191:
1181:
1127:30 May
1083:
1075:
1024:
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738:Caco-2
556:yogurt
512:T cell
393:gluten
377:casein
371:, and
369:gluten
365:barley
1861:5J8D2
1661:(PDF)
1496:ssp.
1444:ssp.
1387:(PDF)
1305:(PDF)
1258:(PDF)
1117:(PDF)
1081:S2CID
921:(PDF)
914:(PDF)
801:ssp.
755:sp.,
683:mucus
462:) by
345:GLB44
139:GLB44
108:GLB44
1939:1585
1934:NCBI
1921:LPSN
1908:ITIS
1882:GBIF
1869:EPPO
1848:6449
1772:ISSN
1727:PMID
1719:ISSN
1639:PMID
1629:ISBN
1574:2014
1536:PMID
1470:PMID
1425:2014
1399:2014
1366:PMID
1270:2014
1234:PMID
1189:PMID
1129:2014
1073:PMID
1022:PMID
977:PMID
942:link
831:PMID
805:and
566:and
544:GRAS
397:soya
280:The
1856:CoL
1762:doi
1711:doi
1526:PMC
1516:doi
1460:doi
1456:104
1356:PMC
1348:doi
1340:Age
1224:doi
1179:PMC
1171:doi
1065:doi
1012:doi
1008:180
969:doi
821:doi
817:269
666:FDA
652:FDA
538:a "
532:FDA
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