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Activated B-Cell
Diffuse Large B-Cell Lymphoma, or ABC-DLBCL, is believed to be caused by aberrant activation of a critical intracellular pathway. This intracellular signaling pathway involved in B-cell activation and proliferation stays constantly activated, driving lymphocytes to proliferate
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continuously. The inhibition of this pathway can be induced by a drug known as NEMO Binding Domain, or NBD, a peptide causing increased cell death of malignant lymphocytes.
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that have turned cancerous. A large cell, in this context, has a diameter of 17 to 20 μm. Other groups of lymphomas in this system are the
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now classifies the phrase "large-cell lymphoma" under "Diffuse large B cell lymphoma".
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is an example of a large-cell lymphoma that involves T cells. Of the large-cell
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321:. Hagerstown, MD: Lippincott Williams & Wilkins. pp.
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Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma
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46:. Unsourced material may be challenged and removed.
1141:Peripheral T-cell lymphoma not otherwise specified
314:
175:divides the diseases according to the size of the
963:Precursor T acute lymphoblastic leukemia/lymphoma
517:Precursor B acute lymphoblastic leukemia/lymphoma
284:Less commonly, a large-cell lymphoma may feature
259:, which are often diffuse large-B-cell lymphomas
203:is the most common of the large-cell lymphomas.
171:have large cells. One classification system for
707:Nodular lymphocyte predominant Hodgkin lymphoma
1097:Secondary cutaneous CD30+ large-cell lymphoma
429:
8:
787:Post-transplant lymphoproliferative disorder
742:immunoproliferative immunoglobulin disorders
1300:Diffuse infiltrative lymphocytosis syndrome
1339:Jessner lymphocytic infiltrate of the skin
1010:
941:
903:
885:Primary cutaneous follicle center lymphoma
630:Primary cutaneous follicle center lymphoma
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317:Clinical hematology: theory and procedures
129:
120:
348:at the U.S. National Library of Medicine
143:primary mediastinal large B-cell lymphoma
106:Learn how and when to remove this message
865:Primary cutaneous marginal zone lymphoma
663:Primary cutaneous marginal zone lymphoma
257:Primary central nervous system lymphomas
1327:with bandlike and perivascular patterns
1289:Autoimmune lymphoproliferative syndrome
305:
1136:Enteropathy-associated T-cell lymphoma
7:
1284:X-linked lymphoproliferative disease
44:adding citations to reliable sources
1240:Large granular lymphocytic leukemia
860:Intravascular large B-cell lymphoma
242:Primary mediastinal B-cell lymphoma
14:
237:Intravascular large-cell lymphoma
145:, a type of large-cell lymphoma.
20:
1092:CD30+ cutaneous T-cell lymphoma
31:needs additional citations for
1322:Cutaneous lymphoid hyperplasia
1314:Cutaneous lymphoid hyperplasia
1173:Adult T-cell leukemia/lymphoma
1051:Adult T-cell leukemia/lymphoma
990:Anaplastic large-cell lymphoma
870:Primary cutaneous immunocytoma
811:Splenic marginal zone lymphoma
290:Anaplastic large-cell lymphoma
265:: Diffuse Large B-cell Variant
227:Follicular large-cell lymphoma
1:
1370:Lymphoproliferative disorders
1280:Lymphoproliferative disorders
1230:Extranodal NK-T-cell lymphoma
1102:Lymphomatoid papulosis type A
1081:Lymphomatoid papulosis type B
995:Lymphomatoid papulosis type A
855:Diffuse large B-cell lymphoma
313:Turgeon, Mary Louise (2005).
296:, it has the best prognosis.
201:Diffuse large B-cell lymphoma
1262:Acute biphenotypic leukaemia
1151:Subcutaneous T-cell lymphoma
1203:Aggressive NK-cell leukemia
1076:Pleomorphic T-cell lymphoma
782:Lymphomatoid granulomatosis
246:T-cell–rich B-cell lymphoma
1412:
456:
137:
128:
1355:Hematological malignancy
1208:Blastic NK cell lymphoma
1036:Granulomatous slack skin
792:Classic Hodgkin lymphoma
691:Classic Hodgkin lymphoma
350:Medical Subject Headings
263:Richter's transformation
268:1) ABC subtype (common)
232:Immunoblastic lymphoma
1234:Angiocentric lymphoma
824:AIDS-related lymphoma
648:Splenic marginal zone
271:2) GCB subtype (rare)
218:Angiocentric lymphoma
214:feature large cells:
55:"Large-cell lymphoma"
1396:Non-Hodgkin lymphoma
1332:with nodular pattern
1031:Pagetoid reticulosis
643:marginal zone B-cell
185:mixed-cell lymphomas
181:small-cell lymphomas
169:large-cell lymphomas
40:improve this article
831:Helicobacter pylori
658:Nodal marginal zone
585:Hairy cell leukemia
451:and related disease
346:Large+cell+lymphoma
124:Large-cell lymphoma
1375:Lymphoid leukemias
1295:Leukemoid reaction
1131:Angioimmunoblastic
797:Burkitt's lymphoma
222:Burkitt's lymphoma
1383:
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1026:Mycosis fungoides
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695:Nodular sclerosis
610:follicular B cell
411:
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177:white blood cells
165:
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118:Medical condition
116:
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1145:Lennert lymphoma
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769:Primary effusion
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294:T-cell lymphomas
212:B-cell lymphomas
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606:germinal center
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253:lymphoma (rare)
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1045:Sézary disease
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976:Prolymphocytic
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574:Prolymphocytic
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368:Classification
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360:External links
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1272:Lymphocytosis
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1126:Hepatosplenic
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971:prolymphocyte
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880:Plasmacytosis
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836:MALT lymphoma
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639:marginal zone
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57: –
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51:Find sources:
45:
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29:This article
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18:
17:
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1160:By infection
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947:development/
875:Plasmacytoma
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756:By infection
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537:naive B cell
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496:development/
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96:October 2021
93:
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62:
50:
38:Please help
33:verification
30:
1042:aggressive:
1015:MF+variants
554:Mantle cell
549:mantle zone
210:Many other
1118:peripheral
615:Follicular
445:Leukaemias
300:References
139:Micrograph
66:newspapers
1253:Lymphoid+
1023:indolent:
1006:Cutaneous
847:Cutaneous
625:GCB DLBCL
620:Burkitt's
449:lymphomas
173:lymphomas
155:Specialty
1390:Category
1360:leukemia
918:leukemia
913:lymphoma
472:leukemia
467:lymphoma
249:Primary
160:Oncology
1348:General
1255:myeloid
1217:T or NK
1188:NK cell
542:CLL/SLL
402:D016403
286:T cells
251:splenic
80:scholar
1192:(most
1168:HTLV-1
1060:Non-MF
949:marker
922:(most
908:T cell
580:CD11c+
498:marker
476:(most
462:B cell
352:(MeSH)
329:
280:T cell
196:B cell
82:
75:
68:
61:
53:
1115:Other
985:CD30+
731:CD138
702:CD20+
596:CD79a
391:200.7
191:Types
141:of a
87:JSTOR
73:books
1194:CD56
1088:CD30
1067:CD30
955:TdT+
899:T/NK
764:KSHV
740:see
727:CD38
718:PCDs
682:CD30
678:CD15
653:MALT
565:CD22
506:TdT+
483:CD20
478:CD19
397:MeSH
386:9-CM
327:ISBN
205:MeSH
183:and
167:The
59:news
1225:EBV
1090:+:
1069:-:
959:ALL
934:CD8
929:CD4
924:CD3
819:HIV
805:HCV
776:EBV
680:+,
527:CD5
513:ALL
382:ICD
323:221
288:.
42:by
1392::
957::
945:By
733:+)
729:+/
722:PP
684:+)
674:RS
494:By
447:,
400::
389::
325:.
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384:-
374:D
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84:·
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36:.
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